baber/WOPTO huggingface dataset:
Patent PT-984728-E (PT)
Inventor: HAID REGIS W
IPC: A61B17/80
Filed: 1998-05-12
Abstract: In one embodiment of the invention, an anterior fixation system includes a plate defining a plurality of screw holes, a number of screws and a number of locking assemblies for fixing the screws to the plate. The system includes two bone screws, a fixed angle screw and a variable angle screw. Either the fixed or variable angled screws may be implanted with a single plate, and either type of screw may be placed into any of the screw holes along the plate. An intermediate portion of the fixed angle screw is configured to reside within the cylindrical portion of any of the holes when the screw is fixed to the plate such that it is prevented from rotating or pivoting within the hole and is non-threaded. The several screw holes may be in various patterns. The invention further contemplates a locking assembly to lock one or more bone screws within a respective screw hole. In one embodiment, the locking assembly includes a washer overlapping one or more screw holes and a locking screw. In another embodiment, a locking washer includes cut-outs corresponding to the screw recesses, along with a notch and key configuration.
Patent PT-1037666-E (PT)
Inventor: DEMICHELE STEPHEN J
IPC: A23L1/30
Filed: 1998-12-04
Abstract: This invention relates to a method for enhancing the absorption of oil soluble (lipophilic) compounds such as oil soluble vitamins, hormones, nutrients and drugs in an animal. The inventive method comprises administering a lipophilic compound in conjunction with a structured glyceride component characterized in that at least 40% of the glyceride species have: (i) about 33 to 70 wt. % of acyl moieties having 4 to 12 carbon atoms; (ii) about 30 to 67 wt. % of acyl moieties having more than 12 carbon atoms; and (iii) an equivalent carbon number greater than 30 and less than 48. This invention also relates to compositions suitable for administrating to an animal comprising a lipophilic compound and a structured glyceride component characterized in that at least 40% of the glyceride species have: (i) about 33 to 70 wt. % of acyl moieties having 4 to 12 carbon atoms; (ii) about 30 to 67 wt. % of acyl moieties having more than 12 carbon atoms; and (iii) an equivalent carbon number greater than 30 and less than 48. The method and compositions of the invention are especially suited for animals that suffer from lipid malabsorption conditions such as Crohn's disease, Cystic fibrosis, and short bowel syndrome.
Patent SG-73894-G (SG)
Title: Pharmaceutical formulations containing melphalan or melphalan hydrochloride, as well as melphalan and melphalan hydro-chloride and processes for preparing them
Inventor: POOLE STEPHEN WILLIAM
IPC: A61P35/00
Filed: 1994-06-03
Abstract: The present invention relates to a new two-component pharmaceutical formulation of melphalan in which the two components comprise     a) freeze-dried mephalan hydrochloride and b) a solvent-diluent comprising a citrate, propylene glycol and ethanol. Substantially pure melphalan, substantially pure melphalan hydrochloride and methods for preparing them are also described.
Patent SG-77086-G (SG)
Title: Isomerization process
IPC: C10G35/095
Filed: 1986-09-24
Abstract: Long chain (C7+) paraffins are isomerized over a large pore, highly siliceous zeolite catalyst such as zeolite Y or ZSM-20 having a structural silica:alumina ratio of at least 10:1; the use of such highly siliceous zeolites inhibits the degree of cracking and also permits weaker hydrogenation components such as palladium to be used in the catalysts.
Patent IE-33968-L (IE)
Title: Polyurethane foams
IPC: C08G18/40
Filed: 1970-02-03
Abstract: 1301278 Polyurethane foams DUNLOP HOLDINGS Ltd 20 Feb 1970 [22 Feb 1969] 9649/69 Heading C3R Flame-resistant polyurethane foams are prepared by adding to a foam-forming reaction mixture of a polymere polyol, an organic polyisocyanate and a blowing agent, a flame retardant which is a hydroxypolyoxyalkylene derivative of a substance of the formula wherein Ar and Ar<SP>1</SP> denote hydroxy-substituted phenyl groups and R and R<SP>1</SP> denote alkyl groups. Specified flame retardants are reaction products of bisphenol-A and prophylene or ethylene oxide, the latter alternative having for example the formula wherein x and y represent 2, 3, 4 or 5 independently. The polyisocyanate reactant is preferably a crude tolylene-diisocyanate. The polyol reactant may be a polyether or polyester polyol, and preferably a poly(oxypropylene)- poly(oxyethylene) triol having a molecular weight of 5,000. Water is exemplified as a blowing agent.
[GB1301278A]
Patent IE-40765-L (IE)
Title: Controlling foaming in fermentation
IPC: C12M1/36
Filed: 1975-03-07
Abstract: 1470861 Citric acid PFIZER Ltd 7 March 1975 [8 March 1974] 10616/74 Heading C2C [Also in Division C6] In a continuous fermentation with a microorganism in a nutrient medium in which the main substrate has an antifoaming action, but in which no other antifoaming agent is added, the addition of the substrate to the fermentation broth is controlled by monitoring the amount of the foam and adding a sufficient amount of substrate to reduce the amount of foam when the foam exceeds a predetermined level. An example describes the microbiological production of citric acid by cultivation of Candida lipolytica ATCC 20228 on a C 14 -C 17 n-paraffin substrate. It is stated that the medium first begins to foam when the original hydrocarbon substrate therein has been exhausted. Further foaming occurs as each charge of substrate is used up. The requisite apparatus includes a foam probe 12 electrically connected to a control panel 13 which controls a pump or valve 14 in the substrate supply line 16. The amount of substrate added when the means is actuated may be limited by a timing device (not shown). The apparatus is fitted with an air line 3, and heater 6 and cooler 7 controlled by a temperature probe 8. Specification 1,369,295 is referred to.
[GB1470861A]
Patent IE-840563-L (IE)
Title: 1,4-disubstituted piperidines
IPC: C07D211/32
Filed: 1984-03-08
Abstract: The invention relates especially to pharmaceutical preparations containing N-(piperidinyl-alkyl)-carboxamides of the general formula <IMAGE> (1) in which R represents hydroxy, hydroxy etherified by an aliphatic alcohol, or halogen, Ar1 represents a monocyclic arylene or heteroarylene radical, alk represents an alkylene group that separates the two N atoms by at least two carbon atoms, X represents a free or ketalized carbonyl group, free hydroxymethylene or hydroxymethylene esterified by an organic carboxylic acid, or methylene, and Ar2 represents a monocyclic aryl or heteroaryl radical, and salts thereof, the use of these compounds of the formula I and salts thereof, novel compounds of the formula I and salts thereof in which R, Ar1, alk, X and Ar2 have the meanings given, with the proviso that the grouping R-Ar1 is other than a radical of the formula <IMAGE> (Ia) in which R1 is selected from the group consisting of lower alkyl, trifluoromethyl, halogen, lower alkoxy, nitro and cyano and at least one of the radicals R1 represents halogen or lower alkoxy, n represents an integer from 1 to 3, and Z represents nitro, amino, lower alkylamino, arylamino, aryl-lower alkylamino, (thio-)formylamino, (thio-)lower alkanoylamino, (thio-)aroylamino or aryl-(thio-)lower alkanoylamino, if alk and X have the meanings given and Ar2 represents unsubstituted phenyl, thienyl or pyridyl or substituted phenyl having one, two or three substituents selected from the group consisting of halogen, lower alkyl, lower alkoxy, trifluoromethyl and amino, and to processes for the manufacture thereof.
[US4559349A]
Patent IE-800802-L (IE)
Title: Electrode assembly
IPC: C25B11/02
Filed: 1980-04-21
Abstract: Electrode, particularly an anode, for use in electrometallurgical cells in which the electrode is formed of two very thin sheets of titanium which are corrugated and arranged in a mirror image position, being spot welded where they touch each other and being spot welded to a titanium sheathed hanger bar. The electrode, which is particularly suitable as an anode, can be formed from very thin titanium and has enhanced stiffness resulting from the corrugations which strengthen the overall construction.
[US4319977A]
Patent IE-33186-L (IE)
Title: Quinazoline-thiones
IPC: C07D239/78
Filed: 1969-06-30
Abstract: 1,265,548. Quinazeline-thione derivatives. SANDOZ Ltd. 13 June, 1969 [1 July, 1968; 15 April, 1969; 25 April, 1969], No. 30195/69. Heading C2C. Novel compounds I (including salts of the dialkylamino compounds) wherein x y signifies -CR 2 = N- or R is H, F, Cl, Br, C 1 to C 5 alkyl, C 1 to C, alkoxy or alkylthio, NO 2 , CF 3 or di -C 1 to C 4 alkylamino, n is 1 or 2 provided that when n is 2 the R's (may be same or different) signify H, F, Cl, Br, C 1 to C 5 alkyl or C 1 to C 4 alkoxy, R 1 is C 1 to C 5 alkyl, allyl or propargyl and R 2 is phenyl or Y,Y i -substituted phenyl (Y is F, Cl, Br, C 1 to C 4 alkyl, C 1 to C 4 alkoxy or CF 3 and Y 1 is H, F, Cl, Br, C 1 to C 4 alkyl or C 1 to C 4 alkoxy), are obtained: (a) by interacting phosphorus pentasulphide and compounds III (prepared by reacting compounds IV with a urethane; IV are obtained by alkylation of corresponding primary amines ) ; (b) by reacting IV with a carboxylic acid chloride or bromide and MNCS (M is alkali or alkaline earth metal cation or the ammonium cation) or with the reaction product thereof or with isothiocyanic acid (conveniently prepared in situ); (c) by reacting isothiocyanic acid with compounds VI (prepared by interaction of IV and, e.g. sodium borohydride); or (d) by interacting an aldehyde, Y<SP>1</SP> 1 C 6 H 4 .CHO, and compounds IX (prepared by saponification of appropriate acylated thioureas; R<SP>1</SP> is H, F, Cl, Br, C 1 to C 5 alkyl or C 1 to C 4 alkoxy, R<SP>1</SP> 1 is C 1 to C 5 alkyl, n<SP>1</SP> is 1 or 2 provided that when n<SP>1</SP> is 2 no more than one R<SP>1</SP> is halogen or a branched chain substituent and provided that R<SP>1</SP> is other than a branched chain substituent when in the 5- or 8-position, and Y<SP>1</SP> 1 is H, F, Cl, Br, C 1 to C 3 alkyl or C 1 or C 2 alkoxy). N - Isopropyl - N - (m - tolyl) - N<SP>1</SP> - benzoylthiourea is obtained by reacting N-isopropyl-3- methylaniline with benzoyl chloride in the presence of ammonium thiocyanate. Pharmaceutical preparations showing, in particular, activity contain I as active ingredient; administration is orally or parenterally.
[GB1265548A]
Patent IE-35543-L (IE)
Title: Pyrazine derivatives
IPC: C07D241/18
Filed: 1971-08-04
Abstract: 1301228 1-Cyano-2-pyrazinones IMPERIAL CHEMICAL INDUSTRIES Ltd 13 July 1971 [4 March 1971] 6029/71 Heading C2C The invention comprises compounds of formula wherein R<SP>1</SP>, R<SP>2</SP> are each C 1-4 alkyl, and a process for making them by reacting a cyanogen halide with the corresponding 3,5-dialkyl-2-pyrazinol in presence of a base which converts the latter to its anion. The above compounds may be reacted with N 2 H 4 to give the 3-amino-6,8-dialkyl-striazolo[4,3 a]pyrazine.
[GB1301228A]
Patent IE-891062-L (IE)
Title: N2-(1-carboxy-3-phenylpropyl)-l-lysine derivative and¹process of producing lysinopril using the compound
IPC: C07K14/81
Filed: 1989-04-04
Abstract: NEW MATERIAL:Compounds expressed by formula I (R<1> is protecting group; R<2> is H, alkyl, etc.; X is CN, etc.; * represents S-configuration to asymmetric carbon). formula II (Y is CN, etc.) and formula III (R<3> is H, alkyl, etc.). EXAMPLE:N<2>-[1(s)-Cyano-3-phenylpropyl]-N<6> trifluoroacetyl-L-lysin, N-carboxy anhydride thereof and N<2>-[1(s)-carbamyl-3-phenylpropyl]-N<6>-trifluoroacetyl-L-lysin- L-proline. USE:An intermediate for antihypertensive. PREPARATION:beta-Phenylpropionaldehyde is reacted with prussic acid and a compound expressed by formula IV to afford the compound expressed by formula V wherein X is CN in formula I. A compound expressed by formula II is reacted with a compound expressed by formula VI to give the compound expressed by formula VII wherein Y is X in formula III, which is further hydrolyzed to provide the compound expressed by formula VIII useful as antihypertensive.
[JP1254651A]
Patent IE-801109-L (IE)
Title: Plasmid vectors
IPC: C12P21/00
Filed: 1980-05-28
Abstract: A plasmid having an insertion site for a eukaryotic DNA fragment adjacent to a bacterial promoter and downstream from a prokaryotic ribosome binding site and initiator codon such that the bacterial promoter controls transcription and translation of an inserted DNA fragment is disclosed. The production and use of such plasmids is also disclosed. In general terms, one aspect of the present invention relates to a series of plasmid vectors having the basic characteristic of a Hind III insertion site adjacent to a tryptophan promoter and also a gene for tetracycline resistance. The plasmid vectors are by virtue of the structure thereof ideally suited to receive at the Hind III site an inserted eukaryotic DNA fragment the transcription and translation of which is under the control of the tryptophan promotor.
[US4349629A]
Patent IE-45734-L (IE)
Title: Selectively blocking amino groups.
IPC: A61P31/04
Filed: 1977-06-14
Abstract: Selective blocking of some amino groups in a polyaminoorganic compound having at least one pair of available neighboring hydroxyl and amino groups is effected by first preparing in situ transition metal salt complexes of available neighboring amino and hydroxyl group pairs in said polyamino-organic compound, followed by introduction of blocking groups of the non-complexed amino groups and, finally removing the transition metal cations from the selectively N-blocked polyamino-organic compound complex to obtain a polyamino-organic compound having selectively blocked amino groups; the selective blocking has application in chemical transformations of polyamino compounds, especially carbohydrates and aminocyclitol-aminoglycsides to obtain good yields.
[CA1265130A]
Patent IE-901373-L (IE)
Title: Soluble interferon-gamma receptors and methods for their¹production
IPC: C12P21/02
Filed: 1990-04-18
Abstract: The present invention relates to soluble IFN- gamma receptors, to DNA sequences coding for these soluble IFN- gamma receptors and methods for making these.
Patent IE-811431-L (IE)
Title: Pyrazinyl oxadiazoles
IPC: A61K/
Filed: 1981-06-26
Abstract: The case concerns novel pyrazinyl-1,2,4-oxadiazole-5-ones and processes for preparing the same. The compounds are useful in the treatment of edema and hypertension.
Patent IE-861494-L (IE)
Title: Protective human monoclonal antibodies to pseudomonas¹aeruginosa exotoxin a
IPC: C07K16/00
Filed: 1986-06-05
Abstract: Cell lines have been produced that secrete human monoclonal antibodies capable of binding to and neutralizing Pseudomanas aeruginosa exotoxin A. These antibodies have been found to be protective against lethal challenges of the exotoxin. Pharmaceutical compositions containing these antibodies, which can be in combination with other monoclonal antibodies, blood plasma fractions and antimicrobial agents, and the prophylactic and therapeutic use of such compositions in the management of infections are included.
[WO8607382A1]
Patent IE-811543-L (IE)
Title: Skin-penetrating compositions
IPC: A61P29/00
Filed: 1981-07-08
Abstract: A large group of lipophilic, pharmacologically active compounds can be effectively delivered across intact skin by applying them topically in a binary, penetration-enhancing vehicle containing (1) a C3-C4 diol, diol ester, or diol ether and (2) a cell envelopedisordering compound. This vehicle provides surprising enhancement of skin penetration for the pharmacological active, compared to either component alone.
[EP0043738A2]
Patent IE-35887-L (IE)
Title: Charge coupled device
IPC: H03K17/56
Filed: 1971-12-10
Abstract: 1358890 Telephone exchanges WESTERN ELECTRIC CO Inc 15 Dec 1971 [16 Dec 1970] 58214/71 Heading H4K [Also in Division H1] A charge coupled device in which charges are transferred from site to site at or adjacent the surface of a storage medium under the influence of a bias voltage, includes means whereby charges may be transferred through the medium to a site at the other surface of the storage medium. In a cross point switch information in the form of groups of charges incoming on any of transmission lines 1, 2 or 3 may be diverted to any of lines a, b or c by energizing the appropriate electrode, e.g. 1a or 2b or 3c so that charge is transferred through the storage medium to the storage sites at the other surface of the medium. The electrodes may be selectively energized from a control network 68.
[GB1358890A]
Patent IE-841588-L (IE)
Title: Nonwoven fabric
IPC: D04H1/44
Filed: 1984-06-22
Abstract: Ribbed terry cloth-like nonwoven fabric produced by fluid entangling of fibers on a special forming belt.
Patent IE-881681-L (IE)
Title: MUTANT t-PA WITH KRINGLE REPLACEMENT
IPC: C07K19/00
Filed: 1988-06-03
Abstract: Tissue plasminogen activator analogs exhibiting greater specificity for fibrin than native t-PA are disclosed. The analogs include the K1 domain of native t-PA replaced with another kringle domain mediating the binding of the analog to fibrin. The kringle contains six cysteine residues. The t-PA analogs may further include a variety of substitutions and modifications. Pharmaceutical compositions containing one or more of the t-PA analogs along with a physiologically acceptable carrier or diluent are also disclosed.
Patent IE-841779-L (IE)
Title: Linear motor
IPC: H02K41/035
Filed: 1984-07-11
Abstract: A disk drive arrangement including RW head actuator (31) driven by an improved voicecoil motor, having ceramic back-magnets (m-1, - m-4) which are subdivided to give improved magnetic characteristics and operation (increased working flux and an increase in efficiency and effective power acceleration for a given current -- e.g., thus decreasing "access time").
[EP0136776A1]
Patent IE-45785-L (IE)
Title: Bottle stopper
IPC: B65D39/18
Filed: 1977-10-05
Abstract: A watertight device for stoppering a bottle, in which a ring, made of flexible matter, is located in a groove or grooves of the stopper stem, the groove or grooves being formed partly with a notched surface, and partly with a smooth and circular external surface. The ring has corresponding mating, notched and smooth surfaces.
[US4108325A]
Patent IE-812111-L (IE)
Title: Immobilized species
IPC: C12N11/08
Filed: 1981-09-10
Abstract: The invention relates to composite materials containing immobilized biological active species. <??>A method for the preparation of a composite material containing an immobilized biological active species is disclosed. In carrying out the method a gel precursor containing a particulate biologically active species is applied to a support material and gelled to form a composite material comprising a support material, a permeable gel and, immobilized in the gel a particulate biologicallt active species. The rheological properties of the gel precursor are selected to facilitate the application to the support material. The rheological properties are also selected to facilitate retention of the gel precursor on the support material prior to and during the gelling, and/or to inhibit the sedimentation of biologically active species prior to, and during gelling. At least some of the permeable gel is enmeshed with the support material. 
[EP0048109A2]
Patent IE-43890-L (IE)
Title: Greenhouse
IPC: A01G9/24
Filed: 1976-12-02
Abstract: 1514586 Greenhouse folding door or ventilator BABY RELAX Ltd 1 Dec 1976 [2 Dec 1975] 49492/75 Headings E1A and E1J A green house has an opening for access and/or ventilation defined by two horizontally spaced vertical members 11, 12 and a cover 14 of flexible sheet material having a plurality of horizontal slats 16 secured thereto at vertically spaced positions. A pair of vertical guides 17 frictionally engage the slats allowing vertical movement of the cover and holding it in a range of partly closed positions. The slats 16 may be channels with lips 18 through which the cover passes and in which it is held by a keeper 19 of plastics tube. The guides 17 may be flexible lines clamped between the keeper and slat through which latter they pass. Similar alternative clamping means are illustrated in Figures 3 and 4 (not shown). Alternatively an irregular section guide may be releasably clamped in edge channels (not illustrated).
[GB1514586A]
Patent NO-773601-L (NO)
Title: Kunstharpikskomponenter for fremstilling av biocide belegg
Inventor: NEFFGEN BERND
IPC: C08G59/30
Filed: 1977-10-20
Abstract: Kunstharpikskomponenter for fremstilling av biocide belegg.
Patent NO-812395-L (NO)
Inventor: FISCHER ARTHUR
IPC: B23B51/00
Filed: 1981-07-13
Abstract: A tool for drilling a cylindrical hole with an enlarged end undercut portion comprises a shank with cutting edges and a drill collet screwed to the shank by a knuckle thread. The collet is provided with a stop collar having a semispherically-shaped face supported in a matingly configurated recess provided in a stop plate so as to form a swivel bearing. A portion of the collet is closed by a bell connected to the stop plate and formed with a central hole to receive the shank of the tool.
Patent NO-822645-L (NO)
Inventor: BRYNIELSSON THORE
IPC: B60R3/02
Filed: 1982-08-02
Abstract: The foot-step is operable by a mechanism including a guide device below the floor of the vehicle for extension of the step outside one side of the vehicle in an outwards/downwards movement and retraction in the opposite direction. 
<??>The foot-step comprises a support structure (3) over which an endless mat (18) is stretched, and means for retaining a portion (19) of the mat (18) in the direction of movement of the foot-step, but not in the vertical direction.
Patent NO-830295-L (NO)
Inventor: MARTIN JOEL LEONARD
IPC: C08F4/64
Filed: 1983-01-28
Abstract: Catalysts effective for the polymerization of olefins at high productivity formed upon mixing (1) a solution of titanium tetrahydrocarbyloxide or a zirconium tetrahydrocarbyloxide and an organoaluminum halide with (2) a dihydrocarbylmagnesium compound alone or admixed with a minor amount of a trialkylaluminum and (3) combining the product obtained in (2) with a metal halide selected from a silicon tetrahalide and a titanium tetrahalide. The catalyst component thus produced can be combined with an organoaluminum compound as a cocatalyst component.
Patent NO-850886-L (NO)
Inventor: ZIMMERMANN ANSO
IPC: A47J41/02
Filed: 1985-03-06
Abstract: The invention relates to an insulating container (1), in particular an insulating flask, with a vacuum glass insert (2) and a hollow cylindrical housing (3) surrounding the latter. Housing (3) consists of an upper part (4) and a lower part (5) which are screwed together, the upper part (4) having an outer screw thread (6) and the lower part (5), in the form of a base with a raised-up edge, having an inner screw thread (8). To cope with different lengths of vacuum glass inserts (2) within a tolerance range the screw thread (6) is made sufficiently long to enable all such inserts to be held firmly between a shoulder (9) in the upper part (4) and a thrust or support piece 12 in the lower part (5). The edge of the housing lower part (5) is provided with a one-piece extension which overlaps the housing upper part (4) beyond the screw thread (6) to form a cover ring (28 ) for any unused area of the screw thread (6).
Patent NO-861868-L (NO)
Inventor: MATASSA VICTOR GIULIO
IPC: A61K31/41
Filed: 1986-05-09
Abstract: The invention concerns novel [5,6]-cis-1,3-oxathiane derivatives of formula I in which R1 and R2 are variously defined as hydrogen, alkyl, trifluoromethyl or phenyl (as set out in the specification), n is 1 or 2, m is 2, 3 or 4, Y is vinylene and Z is carboxy, 1(H)-tetrazol-5-yl or a group of the formula -CO.NH.SO2R3 in which R3 is alkyl, phenyl or benzyl, and pharmaceutically acceptable salts thereof, for use in conjunction with their pharmaceutical compositions in treating certain pulmonary and/or vascular disorders. The invention also describes various processes and intermediates for the manufacture of the novel compounds.