Patent SG-11201903145T-A (SG)
Title: Pharmaceutical complex formulation comprising amlodipine, losartan and chlorthalidone
Inventor: CHO HYUK JUN
IPC: A61K31/4422
Filed: 2017-11-03
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1 MI 1411 0 11101 HOE HI 1 0 0111111E1U 1101 010 HIDE 1111 0E111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2018/084627 A2 11 May 2018 (11.05.2018) WIPO I PCT — (51) (21) (22) (25) Filing Language: (26) (30) (71) Applicant: HANMI PHARM. CO (72) International Patent Classification: gil, Paldal-gu, Suwon-si, Gyeonggi-do 16488 (KR). IM, A61K 9/20 (2006.01) A61K 31/4178 (2006.01) Ho Taek; 117-1204, 27, Yonggu-daero 2394beon-gil, Gi- A61K 31/4422 (2006.01) A61K 31/404 (2006.01) heung-gu, Yongin-si, Gyeonggi-do 16909 (KR). KIM, International Application Number: Yong Il; 732-504, 52, Jeongja-ro 42beon-gil, Jangan-gu, PCT/KR2017/012396 Suwon-si, Gyeonggi-do 16325 (KR). PARK, Jae Hyun; 311-404, 460, Yeongtong-ro, Yeongtong-gu, Suwon-si, International Filing Date: Gyeonggi-do 16707 (KR). WOO, Jong Soo; 120-2303, 03 November 2017 (03.11.2017) 85, Hwasan-ro, Jangan-gu, Suwon-si, Gyeonggi-do 16420 (KR). English Publication Language: English (74) Agent: KIM, Sung Ho et al.; (WANNABE Patent & Law Firm), (Hongeun Bldg., Yeoksam-dong) 5F, 8, Teheran-ro Priority Data: 8-gil, Gangnam-gu, Seoul 06233 (KR). 10-2016-0145518 03 November 2016 (03.11.2016) KR (81) Designated States (unless otherwise indicated, for every ., LTD. [KR/KR]; 214, kind of national protection available): AE, AG, AL, AM, Muha-ro, Paltan-myeon, Hwaseong-si, Gyeonggi-do 18536 AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (KR). CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, Inventors: CHO, Hyuk Jun; B-301, 46, Deogyeong-daero HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, 38 lbeon-gil, Jangan-gu, Suwon-si, Gyeonggi-do 16358 KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (KR). LIM, Sol Ee; #905, 17-9, Gwongwang-ro 196beon- MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, = © uniformity Title: PHARMACEUTICAL COMPLEX FORMULATION 126 4 CHLORTHALIDONE COMPRISING AMLODIPINE, LOSARTAN AND r -- = (54) = = = = = = = = = ei IN ei ,tD iv *t (57) 0 ----. done GO N agent for cardiovascular diseases, which has excellent quality and heat stability. C , 1 chlorthalidone 1 0 20 25 : The present invention relates to a pharmaceutical complex formulation including amlodipine, losartan, and chlorthali- as active ingredients. The pharmaceutical complex formulation of the present invention including amlodipine, losartan and as the active ingredients exhibits excellent dissolution characteristics of the active ingredients, and has high content and heat stability. Therefore, the complex formulation of the present invention can be used as a prophylactic or therapeutic [Continued on next page] WO 2018/084627 A2 IIII0 0 PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — without international search report and to be republished upon receipt of that report (Rule 48.2(g))