Patent SG-11201809317V-A (SG)
Title: Methods for classifying patients with a solid cancer
Inventor: GALON JÉRÔME
IPC: G06F19/00
Filed: 2017-05-09
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111411 0 11101 HOE 010 1111 1 0 I OH 11101111110111011 11110 MAMIE Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/194556 Al 16 November 2017 (16.11.2017) WIPO I PCT (51) International Patent Classification: (72) Inventors: GALON, Jerome; Inserm UMRS1138, Team GO1N 33/574 (2006.01) GOOF 19/00 (2011.01) 15, Cordeliers Research Center, 15 rue de Pecole de (21) International Application Number: medecine, 75006 PARIS (FR). MLECNIK, Bernhard; INSERM UMRS1138, Team 15, Cordeliers Research Cen- PCT/EP2017/061089 ter, 15 me de 1'Ecole de Medecine, 75006 Paris (FR). (22) International Filing Date: PAGES, Franck; INSERM UMRS1138,Team 15, Corde- 09 May 2017 (09.05.2017) hers Research Center, 15 Rue de 1'Ecole de Medecine, (25) Filing Language: English 75006 Paris (FR). (26) Publication Language: English (74) Agent: CABINET PLASSERAUD; 66 me de la Chaussee d'Antin, 75440 PARIS CEDEX 09 (FR). (30) Priority Data: (81) Designated States (unless otherwise indicated, for every 16305536.1 09 May 2016 (09.05.2016) EP kind of national protection available): AE, AG, AL, AM, (71) Applicants: INSERM (INSTITUT NATIONAL DE AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, LA SANTE ET DE LA RECHERCHE MEDICALE) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, [FR/FR]; 101, me de Tolbiac, 75013 PARIS (FR). DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, UNIVERSITE PIERRE ET MARIE CURIE (PARIS HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, 6) [FR/FR]; 4, Place Jussieu, 75005 PARIS (FR). KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, UNIVERSITE PARIS DESCARTES [FR/FR]; 12, me de MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, l'Ecole de Medecine, 75006 PARIS 6 (FR). UNIVERSITE PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, PARIS DIDEROT - PARIS 7 [FR/FR]; 5, me Thomas SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, Mann, 75013 PARIS (FR). ASSISTANCE PUBLIQUE TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = - HOPITAUX DE PARIS [FR/FR]; 3 Avenue Victoria, (84) Designated States (unless otherwise indicated, for every 75004 Paris (FR). kind of regional protection available): ARIPO (BW, GH, — GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = (54) Title: METHODS FOR CLASSIFYING PATIENTS WITH A SOLID CANCER (57) : The invention relates to methods for clas- present = 51 _ SELECTION sifying patients suffering from a solid cancer, particularly to meth- i f ods for the prognosis of the survival time of a patient suffering = S 2 PREPARATION from a solid cancer and/or to methods for assessing the respon- siveness of a patient suffering from a solid cancer to antitumoral — treatment. The method is based on multiple immune quantifying 53 KIT =response markers and determining to which percentile of the dis- = tribution the values correspond when compared to a reference dis- - n=n+1 — 54 tribution. Calculating the mean or median of the determined per- = ASSAY the different this to = , centiles of markers and comparing value a reference value of the mean- or median percentiles, the result of = 55 MEASURE n=n+1 4.-. , .---- which is correlated with survival or responsiveness = • I , 56 QC slt _ 57 DATA 1-1 Ss ALGORITHM SID A 511 ii . in 59 SCORE:.:MODEL DECISION 1-1 Ir -- -- 11 FIGURE 2 © ei C [Continued on next page] WO 2017/194556 Al MIDEDIMOMOIDEIROIDEMOMOHMOHIMHOMEMOIMIE UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))