baber/WOPTO huggingface dataset:
Patent EA-030313-B1 (EA)
Title: METHOD OF REDUCING LEVELS OF IgM, IgG AND IgA IN MAMMALS AND COMPOSITION FOR IMPLEMENTATION THEREOF
Inventor: PONCE RAFAEL A JR
IPC: A61P37/06
Filed: 2008-03-27
Abstract: The invention relates to a method and composition for reducing levels of IgM, IgG or IgA in mammals. This method provides administering a BLyS antagonist which is a TACI-Fc-fusion protein comprising the polypeptide sequence of SEQ ID NO: 23, wherein the modified signal sequence of tissue plasminogen activator (SEQ ID NO: 41) and mycophenolate mofetil (MMF) has been removed from said polypeptide sequence. Said BLyS antagonist and MMF are administered in an amount which acts synergistically to reduce immunoglobulin levels, i.e. the BLyS antagonist is administered at a dosage of 0.25-25 mg/kg and the MMF is administered at a dosage of 500-1000 mg/kg. Said mammal has a B-cell regulated autoimmune disorder arising from antibodies that are directed against the mammal's own (self) antigens or tissues. The composition used to reduce immunoglobulin levels comprises said BLyS antagonist and mycophenolate mofetil.
Patent EA-017117-B1 (EA)
Title: 2-AMINO-3-SULPHONYLTETRAHYDROPYRAZOLO[1,5-a]PYRIDOPYRIMIDINE ANTAGONISTS OF SEROTONIN 5-HTRECEPTORS, METHODS FOR THE PRODUCTION AND USE THEREOF
Inventor: IVASHCHENKO ANDREY ALEXANDROVICH
IPC: A61K31/519
Filed: 2009-04-30
Abstract: The invention relates to the antagonists of serotonin 5-HTreceptors in the form of novel 2-amino-3-sulphonyl-6,7,8,9-tetrahydropyrazolo[1,5-a]pyrido[4,3-e]pyrimidines and substituted 2-amino-3-sulphonyl-5,6,7,8-tetrahydropyrazolo[1,5-a]pyrido[4,3-d]pyrimidines, to medicinal principles and to pharmaceutical compositions containing said medicinal principles in the form of the above-mentioned compounds, to drug substances, as well as to the method for treating and preventing the development of different diseases of the central nervous system (CNS) of human beings and animals, whose pathogenesis is associated with 5-HTreceptors. The substituted 2-amino-3-sulphonyl-6,7,8,9-tetrahydropyrazolo[1,5-a]pyrido[4,3-e]pyrimidines of general formula 1 and the substituted 2-amino-3-sulphonyl-5,6,7,8-tetrahydropyrazolo[1,5-a]pyrido[4,3-d]pyrimidines of general formula 2 or pharmaceutically acceptable salts thereof are claimed:wherein Ar is phenyl optionally substituted with halogen atoms, hydroxyl optionally substituted with C-Calkyl, or 6-membered heteroaryl with 1 or 2 nitrogen atoms; Ris a hydrogen atom, C-Calkyl optionally substituted with phenyl, C-Calkoxycarbonyl; Ris a hydrogen atom, halogen or C-Calkyl; Rand Rare the optionally identical substituents selected from a hydrogen atom and C-Calkyl optionally substituted with phenyl, hydroxy group, or Rand Rtogether with a nitrogen atom, with which they are attached, form 6-membered saturated heterocyclyl with 1-2 heteroatoms selected from nitrogen an optionally substituted with C-Calkoxycarbonyl.
Patent EA-020210-B1 (EA)
Title: Wet granulation using a water sequestering agent
Inventor: SUN THOMAS
IPC: A61K9/20
Filed: 2008-11-06
Abstract: Disclosed are tablets comprising hydrolytically stable formulations of (6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-3-oxo-2H-pyrido[3,2-b][1,4]oxazin-4(3H)-yl)methyl phosphate disodium salt (compound 1) prepared by a wet granulation process.
Patent EA-026673-B1 (EA)
Title: Amide compounds as boosters of antivirals
Inventor: JONCKERS TIM HUGO MARIA
IPC: C07D417/12
Filed: 2009-10-07
Abstract: The present invention relates to compounds that have CYP450 inhibiting properties and are therefore useful as boosters of certain drugs, i.e. they are able to increase at least one of the pharmacokinetic variables of certain drugs when co-administered. The invention further provides the use of said compounds as improvers of the bioavailability of certain drugs. Methods for the preparation of the compounds of the invention and pharmaceutical compositions comprising these compounds are also provided.
Patent EA-020224-B1 (EA)
Title: Two types of crystalline of pinocembrin, their preparation and their use for manufacture of pharmaceutical compositions
Inventor: DU GUANHUA
IPC: A61K31/353
Filed: 2008-11-13
Abstract: Two types of crystalline of pinocembrin of formula (I): α and β, their preparation and their use for manufacture of pharmaceutical compositions. There exists difference between them in bioavailability. They are used for treating and preventing cerebral ischemic diseases by protective action of neurovascular cell, and enhancing blood drug level in vivo.
Patent EA-022461-B1 (EA)
Title: Heterocyclic alkanol derivatives as fungicides
Inventor: NISING CARL FRIEDRICH
IPC: C07D417/04
Filed: 2011-05-24
Abstract: The present invention relates to novel heterocyclic alkanol derivatives, to a method for producing said compounds, to agents comprising said compounds, and to the use thereof as biologically active compounds, in particular for controlling destructive microorganisms in pest management in material protection, and as plant growth regulators.
Patent EA-032880-B1 (EA)
Title: Method of producing a packaged lactose-reduced milk-related product and milk-related product obtainable thereby
Inventor: HOLST HANS HENRIK
IPC: A23C9/142
Filed: 2011-07-22
Abstract: The invention relates to lactose-reduced milk-related products having an improved long shelf-life and also to a method of producing such products. In accordance with the invention claimed is a method of producing a packaged, lactose-reduced milk-related product having a reduced cooked taste and lactose in an amount of at most 0.2% (w/w) relative to the total weight of the lactose-reduced milk-related product, the method comprising the following steps: a) providing a lactose-reduced milk-related feed comprising a total amount of mono- and disaccharides in the range of 1-3.2% (w/w) relative to the total weight of the milk-related feed; b) subjecting the milk-related feed to a high temperature treatment, wherein the milk-related feed is heated to a temperature in the range of 145-160°C, kept in that temperature range for a period of at most 200 msec and then cooled; c) packaging a lactose-reduced milk-related product derived from the HT-treated milk derivative, wherein the method further comprises the step of hydrolysing some of the lactose into glucose and galactose and the step of inactivating enzymes by adjusting the temperature of the milk-related product to a temperature in the range of 70-95°C and keeping the temperature in that range for a period in the range of 30-500 sec to reduce the combined activity of plasmin and plasminogen by at least 60% relative to the untreated product. In an embodiment, the enzyme inactivation step is performed after the step a), and the hydrolysis step is performed after the enzyme inactivation step. In an embodiment, the enzyme inactivation step is performed after the step b), and the hydrolysis step is performed after the step b) and after the enzyme inactivation step. In an embodiment, the enzyme inactivation step is performed after the step b), and the hydrolysis step is performed after the step b) but before the enzyme inactivation step. The obtainable lactose-reduced milk-related product has a furosine value of at most 80 mg/100 g protein on day 49 after the production when kept at a temperature of 25°C during storage or of at most 60 mg/100 g protein on day 49 after the production when kept at a temperature of 5°C during storage. The lactose-reduced milk-related product obtainable by the claimed method has a shelf-life of at least 119 days, when kept at 25°C, said product comprising 0.01-2% (w/w) galactose relative to the total weight of the product, 0.01-2% (w/w) glucose relative to the total weight of the product, at most 0.2% (w/w) lactose relative to the total weight of the product, wherein said product also has a furosine value of at most 80 mg/100 g protein on day 49 after the production when kept at a temperature of 25°C during storage.
Patent EA-030548-B1 (EA)
Title: Method of fabricating a pressure vessel using a variable viscosity solventless prepolymer formulation
Inventor: NETTIS FRANCESCO
IPC: B29C70/86
Filed: 2011-12-05
Abstract: The present invention relates to methods of fabricating components of a pressure vessel using a dicyclopentadiene prepolymer formulation in which the purity of the dicyclopentadiene is at least 92%, wherein the formulation further comprises a reactive ethylene monomer that renders the prepolymer formulation flowable at ambient temperatures and to pressure vessels that are fabricated by said methods.
Patent EA-027059-B1 (EA)
Title: Fluoromethyl-5,6-dihydro-4h-[1,3]oxazines
Inventor: HILPERT HANS
IPC: C07D413/12
Filed: 2013-01-23
Abstract: The present invention provides compounds of formula Ia-1having β-secretase 1 (BACE1) inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances in the treatment and/or prophylactics of diseases and disorders characterized by elevated β-amyloid levels and/or β-amyloid oligomers and/or β-amyloid plaques and further deposits, e.g. Alzheimer's disease.
Patent EA-024518-B1 (EA)
Title: Low-friction, abrasion resistant and easy-to-clean composite iron sole plate, method for producing the same and iron comprising the same
Inventor: TAHINCIOGLU BESIM
IPC: D06F75/38
Filed: 2012-05-03
Abstract: The present invention relates to a composite iron sole plate coated using sol-gel process with hydrolysis and condensation products of silanes with a metal precursor. The selected silanes are MTEOS and TEOS which give improved and tailored coatings for iron sole plates along with a metal precursor. The invention also relates to a novel method of producing iron sole plates having this coating, as well as an iron having such sole plate. The coating composition, when applied to an iron sole plate, found to be improving surface characteristics in terms of low friction, abrasion resistance, shine prevention and ease of cleaning due to its chemical stability and flatness.
Patent EA-025665-B1 (EA)
Title: Method of regulating a plant comprising cogenerating installations and thermodynamic systems intended for air conditioning and/or heating
Inventor: MOREAU CHRISTIAN
IPC: F25B9/00
Filed: 2013-06-04
Abstract: Method of managing a plant comprising cogenerating installations and thermodynamic systems, and a computing machine, said method comprising the following steps: a) "base data" are entered into the computing machine, comprising at least the resilience to electrical impact of the cogenerating installation, and the value of maximum intensity of the heat pump, b) "instantaneous data" are entered into said computing machine, comprising at least the state of the cogenerating installation, the state of the heat pump and the electrical power demanded by the heat pump, c) "target data" are defined, to which are assigned a respective "target value" in said computing machine, these target data comprising at least the minimum and/or maximum production of electricity by the plant, optionally the maximum consumption of electricity and of primary energy, and at least one from among: the temperatures of very hot water (T2), of hot water (T1), of cold water (T3), of evaporation of coolant fluid (T4, T5), and the electricity demand of the local network, d) the plant is regulated with the aid of said computing machine in such a way as to attain, for each of the target data selected, the target value or values which have been assigned thereto, the regulation being performed by adjustment of at least one "adjustment datum", in such a way that the current value of each target datum selected is made to approach the target value assigned to it in step c), the at least one adjustment datum comprising the electrical power provided by the cogenerating installation.
Patent EA-029163-B1 (EA)
Title: Substrate provided with a stack having thermal properties and an absorbent layer
Inventor: JRIBI RAMZI
IPC: C03C17/36
Filed: 2013-09-20
Abstract: The invention relates to a glass substrate coated on one surface with a stack of thin layers having reflective properties in the infrared and/or in the solar radiation band, comprising a single metal functional layer, in particular of silver or a metal alloy containing silver, and two dielectric coatings, said coatings each comprising at least one dielectric layer, said functional layer being arranged between the two dielectric coatings, said stack comprising a single absorbent layer, characterised in that said absorbent layer is a metal layer having a physical thickness of 0.5 to 1.5 nm, preferably of 0.6 to 1.2 nm, and is located directly on said surface and directly under a dielectric layer of nitride and not comprising any oxygen.
Patent EA-028772-B1 (EA)
Title: Assembly for producing a galling-resistant threaded tubular connection
Inventor: GARD ERIC
IPC: F16L15/00
Filed: 2013-12-17
Abstract: The invention concerns an assembly for the production of a threaded connection, comprising a first and a second tubular component each with an axis of revolution (10) and each provided at one of their ends (1, 2) with a threaded zone (3; 4) produced on the outer or inner peripheral surface of the component depending on whether the threaded end is male or female in type, said ends (1, 2) being capable of cooperating by makeup and ending in a terminal surface (7, 8), at least one first contact surface being provided on one of the ends (1, 2) and at least one second contact surface being provided on the corresponding end (1, 2), such that the first and second contact surfaces come into contact during makeup of the ends (1, 2), characterized in that the first and second contact surfaces are respectively each coated with a first and a second dry thermoplastic film the matrices of which are constituted by one or more thermoplastic polymers, only one of the first and second dry thermoplastic films further comprising a liquid amorphous thermoplastic resin with a dynamic viscosity in the range 2000 to 40000 mPa∙s at 25°C.
Patent EA-033188-B1 (EA)
Title: Method for oil recovery enhancement
Inventor: ISMAILOV FAKHREDDIN SATTAR OGLY
IPC: E21B43/22
Filed: 2017-03-14
Abstract: The invention relates to oil field development, more specifically to microbiological methods for oil recovery enhancement. The proposed invention objective is to enhance oil recovery using relatively inexpensive reagents, and to increase the oil recovery factor. The objective is achieved by provision of an oil recovery enhancement method comprising organic matter injection into a formation, wherein, prior to injecting the organic matter, low-saline water is injected into the rim in an amount of 30% of the pore volume, and 10-15% solution of cheese whey and cottage cheese whey in law-salinity water is used as the organic matter, the components ratio being as follows, wt.%: cheese whey - 75, cottage cheese whey - 25.
Patent EA-031152-B1 (EA)
Title: Multipurpose aircraft and system of aircrafts
Inventor: MIRZEABASOV TIMUR AKHMEDBEKOVICH
IPC: B64C37/02
Filed: 2015-06-29
Abstract: The invention relates to a multipurpose aircraft, and more particularly to a hybrid dirigible. An aircraft contains a body (2) in the form of a parallelepiped, and is provided with docking means (8) comprising four rods which are connected by a frame and which can be extended from the housing (2); at least one suction element, intended for connecting to a substantially vertical surface of a building, is provided on the ends of the rods. The docking means (8) comprise grippers which are capable of engaging with the docking means (8) of another aircraft of the same design. The invention also relates to a system of aircrafts, including two or more aircrafts having the above design. The proposed aircraft does not require a large space for takeoff and allows for the mass evacuation of people from tall buildings using the fastest and safest method for those being evacuated. In addition, the invention provides the possibility of adjusting the carrying capacity of a system of aircrafts, in the air, in accordance with specific requirements.
Patent EA-038648-B1 (EA)
Title: Radioprotective property of aminocaproic acid
Inventor: SALIEV TIMUR MUJDINOVICH
IPC: A61K31/197
Filed: 2018-09-25
Abstract: The invention relates to medicine, in particular, to radiation therapy. The objective of the invention is ensuring the protection of medical personnel engaged in servicing radiation emitting equipment, military and civil personnel attending nuclear reactors, and personnel of space stations, against radiation induced side effects. It's proposed to use -aminocaproic acid (6-amino hexanoic acid) of a formula C6H13NO2 as a radioprotective agent. The results of studies showed a capacity of -aminocaproic acid to act as a radiation-preventive agent for suppressing the formation of reactive oxygen intermediates and subsequent DNA structure damage caused by ionizing radiation. The data of our experiments showed a therapeutic potential of ACA for the prevention of the radiation-mediated damage of DNA in leukocytes that are very sensitive to ionizing radiation. Radiation protection of white blood cells is a critical challenge for national public health services, in particular, for the protection of cancer patients who regularly take radiation therapy as a major component of cancer therapy.
Patent EA-035534-B1 (EA)
Title: Salts of an lsd1 inhibitor
Inventor: LI QUN
IPC: A61K31/44
Filed: 2016-08-11
Abstract: The present invention relates to tosylate salts of 1-{[4-(methoxymethyl)-4-({[(1R,2S)-2-phenylcyclopropyl]amino}methyl)piperidin-1-yl]methyl}cyclobutanecarboxylic acid, methods of preparation thereof, and intermediates in the preparation thereof, which are useful in the treatment of the LSD1-associated or mediated diseases such as cancer.
Patent EA-036988-B1 (EA)
Title: Ultrasound method for angular velocity measuring
Inventor: Durukan Yasemin
IPC: G01P3/44
Filed: 2019-11-05
Abstract: A method for angular velocity measuring relates to the field of instrument engineering, namely, to the orientation and navigation devices, and to mobile objects control systems, and is intended for measuring the angular velocity. The method consists in excitation of linearly polarized volumetric acoustic wave in an object made of isotropic material that is rotating perpendicular to the direction of wave propagation, and in reception of the view of the linearly polarized wave that does not coincide with the emitted one. A laminated piezoelectric transmitting transducer excites a linearly polarized wave, which is, under conditions of rotation of the measured object perpendicular to the direction of wave propagation, a set of two waves of elliptic polarization of different types. A receiving transducer receives the component of the polarization vector of another type as compared to that emitted. For example, a shear wave is emitted, and a longitudinal component is received. The amplitude of the received signal is proportional to the rotation velocity of the measured object. The technical result is the simplification of the angular velocity measurement method.
Patent ES-2207348-B1 (ES)
Title: Vaporizador modular para gases licuados del petroleo.
Inventor: CONCHESO FERNANDEZ GERARDO
IPC: F17C9/02
Filed: 2001-02-15
Granted: 2005-07-16
Abstract: Vaporizador modular para gases licuados del petróleo. Vaporizador para gases licuados del petróleo que presenta como elemento característico el hecho de separar los elementos de regulación del intercambiador por lo que se dispone de un cuerpo de intercambio (1), de entre los existentes en el mercado para otras aplicaciones, siendo más manejable, fácil y rápido para su manejo, mantenimiento y sustitución, que está conectado a un separador (2) por medio de una tubería (3), que hace las funciones de separación de las gotas de líquido por medio de unos deflectores (5), así como impedir el paso del líquido a la red de consumo y hacer de colector de los elementos condensados de difícil vaporización.
Patent ES-2181586-B1 (ES)
Title: Producto farmaceutico para el tratamiento de tumores cancerigenos.
Inventor: BLANCO COBO ALFONSO
IPC: A61P35/00
Filed: 2001-05-03
Granted: 2004-06-16
Abstract: Producto farmacéutico para el tratamiento de tumores cancerígenos. Este producto farmacéutico incluye en su composición: sulfato de estroncio entre el 30 y 35%, nitrato de bario entre el 30 y 35%, cordierita molida entre el 15 y 20%, pistomesita molida entre 15 y 20% y glicerina entre el 0,1 y 2%; correspondiendo los porcentajes expresados a cantidades en volumen.
Patent ES-2191570-B1 (ES)
Title: Sistema para control horario de aparcamiento.
Inventor: RUIZ DE LOIZAGA ISASI GUSTAVO
IPC: G07B15/02
Filed: 2002-02-27
Granted: 2004-06-16
Abstract: Sistema para control horario de aparcamiento. Cuenta con una o más redes de telefonía móvil y con terminales estándar de usuario. En una primera etapa el usuario aporta mediante su terminal datos de número de matrícula, zona de aparcamiento y tasa que abona. En una segunda etapa el sistema almacena dichos datos y los envía a unos terminales portátiles de un personal de vigilancia. En una tercera etapa el personal de vigilancia introduce en su terminal matrículas de vehículos aparcados para verificar si han aparcado legalmente, esto es habiendo transmitido los datos referidos en la primera etapa. En una realización, el sistema (1) se estructura en un módulo de administración (2) que cuenta con un centro de atención al usuario (5) un subsistema de gestión de bases de datos de abonados, servicio y facturación (6) y un subsistema de gestión de transacciones (7); en un módulo de seguridad (3) que cuenta con un subsistema de seguridad en comunicaciones (8) y con un subsistema de autentificación de usuario (9); y en un módulo de comunicaciones de radio (4) que cuenta con un subsistema de comunicaciones (10) y con un subsistema de comunicaciones Bluetooth (11).
Patent ES-2224825-B1 (ES)
Title: Protector mixto para plantas.
Inventor: NAVARROS REYES FRANCISCO BRUNO
IPC: A01G13/10
Filed: 2002-11-27
Granted: 2007-05-16
Abstract: Se trata de un nuevo protector concebido para proteger plantas en sus distintas fases de desarrollo, fundamentalmente iniciales. Debido a un especial diseño mixto, que combina una mitad del protector de un material antirradiación y la otra mitad de rejilla ventiladora, se consigue un ambiente microclimático ideal para la supervivencia y crecimiento de las especies. De esta forma se evita el efecto invernadero y se protege a las plantas de los excesos de radiación (efecto umbría). Está orientado inicialmente para plantas destinadas a la forestación de tierras agrarias, repoblaciones forestales, etc, aunque su uso se puede extrapolar a otros campos como la jardinería, agricultura, viverismo, etc...
Patent ES-2254022-B1 (ES)
Title: Recubrimiento reciclable y biodegradable para superficies interiores de vehiculos.
Inventor: VILAMALA I SALA JORDI
IPC: D03D15/225
Filed: 2004-11-16
Granted: 2007-05-16
Abstract: Recubrimiento reciclable y biodegradable para superficies interiores de vehículos. Este recubrimiento es aplicable en superficies interiores de vehículos y comprende un cuerpo laminar constituido por, al menos, una capa de tejido de hilo y/o cinta de papel. Dicho tejido de papel puede estar provisto de un tratamiento con aditivos para mejorar sus propiedades y agentes fungicidas y/o bactericidas y/o de un tratamiento con pigmentos o colorantes para su decoración.