Patent SG-11201805770U-A (SG)
Title: BCMA and CD3 Bispecific T Cell Engaging Antibody Constructs
Inventor: RAUM TOBIAS
IPC: C07K16/28
Filed: 2017-02-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization MD 1101111 0 11101 0I0 11111 MEM 0 111 01111 11111 0111 100 HIM III International Bureau 0.. .... .. (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/134134 Al 10 August 2017(10.08.2017) WIPO I PCT (51) International Patent Classification: 81477 Munich (DE). POMPE, Cornelius; c/o Amgen Re- CO7K 16/28 (2006.01) search (Munich) GmbH, Staffelseestrasse 2, 81477 Munich (DE). (21) International Application Number: PCT/EP2017/052202 (74) Agents: WEINZIERL, Gerhard et al.; Schiweck Weinzi- (22) International Filing Date: erl Koch, European Patent Attorneys, Landsberger Strasse 2 February 2017 (02.02.2017) 98, 80339 Munich (DE). (25) Filing Language: English (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (26) Publication Language: English AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (30) Priority Data: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, 62/290,831 3 February 2016 (03.02.2016) US HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (71) Applicants: AMGEN RESEARCH (MUNICH) GMBH KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, [DE/DE]; Staffelseestrasse 2, 81477 Munich (DE). AM- MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, GEN INC. [US/US]; One Amgen Center Drive, Thousand NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, Oaks, California 91320-1799 (US). RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (72) Inventors: RAUM, Tobias; c/o Amgen Research (Mu- ZA, ZM, ZW. nich) GmbH, Staffelseestrasse 2, 81477 Munich (DE). MUENZ, Markus; c/o Amgen Research (Munich) GmbH, (84) Designated States (unless otherwise indicated, for every — Staffelseestrasse 2, 81477 Munich (DE). BROZY, Jo- kind of regional protection available): ARIPO (BW, GH, hannes; c/o Amgen Research (Munich) GmbH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Staffelseestrasse 2, 81477 Munich (DE). KUFER, Peter; TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, c/o Amgen Research (Munich) GmbH, Staffelseestrasse 2, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, 81477 Munich (DE). HOFFMANN, Patrick; c/o Amgen DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Research (Munich) GmbH, Staffelseestrasse 2, 81477 Mu- nich (DE). FRIEDRICH, Matthias; c/o Amgen Research SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, = = - (Munich) GmbH, Staffelseestrasse 2, 81477 Munich (DE). GW, KM, ML, MR, NE, SN, TD, TG). M RATTEL, Benno; c/o Amgen Research (Munich) GmbH, Published: Staffelseestrasse 2, 81477 Munich (DE). BOGNER, — with international search report (Art. 21(3)) _ Pamela; c/o Amgen Research (Munich) GmbH, Staffelseestrasse 2, 81477 Munich (DE). WOLF, Andreas; c/o Amgen Research (Munich) GmbH, Staffelseestrasse 2, = = = = = = = = = 1-1 7r M Il 7r M Il (54) Title: BCMA and CD3 Bispecific T Cell Engaging Antibody Constructs 1-1 C (57) : The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a N first domain binding to BCMA, a second domain binding to an extracellular epitope of the human and/or the Maraca CDR chain en. ) and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody i9 construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising 5 the same.