baber/WOPTO huggingface dataset:
Patent BR-112023019465-A2 (BR)
Title: Modelo de aprendizado de máquina para detectar uma bolha dentro de uma lâmina de amostra de nucleotídeo para sequenciamento
Inventor: BRANDON TYLER WESTERBERG
IPC: G16B40/20
Filed: 2022-03-23
Abstract: trata-se de métodos, sistemas e mídia não transitória legível por computador para detectar com precisão e eficiência quando bolhas impactam as rodadas de sequenciamento de ácido nucleico com base em dados capturados durante (ou derivados de) chamadas de base durante rodadas de sequenciamento. em particular, em uma ou mais modalidades, os sistemas revelados recebem dados que identificam chamadas de nucleobase e dados que identificam métricas de qualidade para as chamadas de nucleobase durante ciclos de sequenciamento. com base em chamadas específicas de nucleobase e marcadores de limite para as métricas de qualidade, o sistema revelado utiliza um modelo de aprendizado de máquina para detectar a presença de uma bolha em uma lâmina de amostra de nucleotídeo. além de simplesmente detectar a presença de uma bolha, o sistema revelado pode também classificar diferentes bolhas detectadas, como bolhas de ar, bolhas de óleo ou bolhas fantasma, ou outras saídas durante o sequenciamento. utilizando dados de chamada e métricas de qualidade, o sistema da revelação pode usar dados de sequenciamento prontamente disponíveis em uma abordagem independente de plataforma para detectar bolhas usando um modelo de aprendizado de máquina treinado exclusivamente.
Patent BR-112023020957-A2 (BR)
Title: Método para preparar uma poliolefina, poliolefina, e, tensoativo
Inventor: RACHEL E M BROONER
IPC: C08F2/38
Filed: 2022-04-29
Abstract: método para preparar uma poliolefina, poliolefina, e, tensoativo. métodos para preparar a poliolefina funcionalizada por extremidade. os métodos incluem polimerizar um ou mais monômeros de olefina na presença de um agente de transferência de cadeia de alumínio para produzir uma espécie de polimeril alumínio. tratar as espécies de polimeril alumínio com composto de óxido de enxofre a uma temperatura de reator para formar um sulfinato de polimerila; e oxidar o sulfinato de polimerila; sendo que a poliolefina funcionalizada por extremidade compreende uma cadeia polimérica principal tendo pelo menos 30 átomos de carbono; e a poliolefina funcionalizada por extremidade compreende um grupo contendo enxofre.
Patent BR-122014023771-A2 (BR)
Title: atuador de extremidade para uso em conexão com um instrumento cirúrgico e atuador de extremidade para fixação a um instrumento cirúrgico
Inventor: FREDERICK E SHELTON IV
IPC: A61B17/072
Filed: 2011-09-28
Abstract: resumo patente de invenção: "atuador de extremidade para uso em conexão com um instrumento cirúrgico e atuador de extremidade para fixação a um instrumento cirúrgico". a presente invenção refere-se a cartuchos cirúrgicos de grampos (900, 900', 940) e atuadores de extremidade (990) para instrumentos de grampeamento cirúrgico (10). em várias modalidades, um elemento de suporte de cartucho (960) é acoplado a uma porção de um corpo implantável de cartucho de grampos. o elemento de suporte de cartucho (960) é configurado para ser acoplado de modo removível a uma porção de canaleta alongada (14) de um instrumento cirúrgico (10). quando o processo de grampeamento termina, o corpo de cartucho (902, 942) implantável permanece grampeado ao tecido e é separado do elemento de suporte de cartucho (960) que permanece afixado à canaleta alongada (14) para dar ao cirurgião uma indicação de que não há nenhum cartucho presente na canaleta alongada (14). em outras modalidades, é fornecida uma disposição de trava de fechamento para impedir o avanço de um elemento de fechamento para uma posição de disparo total quando não há nenhum cartucho de grampos presente no atuador de extremidade (990).
Patent BR-122015024004-A2 (BR)
Title: Método de decodificar uma imagem
Inventor: MIN-SU CHEON
IPC: H04N19/176
Filed: 2010-10-29
Abstract: método de decodificar uma imagem um método e equipamento para a codificação de uma imagem é fornecido. uma unidade codificadora de imagem, que inclui uma região que se desvia dos contornos de uma imagem vigente, é dividida para obter uma unidade codificadora possuindo um tamanho menor do que o tamanho da unidade codificadora de imagem, e a codificação é realizada apenas em uma região que não se desvia dos contornos da imagem vigente. um método e equipamento para a decodificação de uma imagem codificada pelo método e um equipamento para codificar uma imagem é são também fornecidos.
Patent CZ-3698-A3 (CZ)
Title: Glass block element with fire resistance class f
Inventor: FRANEK HENNING DR
IPC: E04B2/14
Filed: 1998-01-07
Abstract: The glass brick unit, for use in single shell walls with a fire resistance class F, is composed of two hollow glass bricks (1,10), bonded together by an adhesive mass (12) along a wall (6,7) forming a visible surface. The visible walls (6,7) of the hollow glass bricks (1,10) have a wall thickness of at least 18 mm. The adhesive mass (12) is transparent and is heat resistant, of a water glass base.
Patent CZ-63592-A3 (CZ)
Inventor: STRMISKA FRANTISEK ING CSC
IPC: F23B90/00
Filed: 1992-03-04
Abstract: Dopravník (1) ústí do násypky (2),jejíž dno jetvořeno roštem (4),pod nímž jsou umístěny kanály (14) pro přívod primárního vzduchu a nad ním jsou umístěny kanály (15) pro přívod sekundárního vzduchu. Rošt (4) je umístěn v konvenčním tahu (5), na nějž navazuje ohřívák (6) vzduchu, jehož vstupní potrubí je opatřeno vzduchovým ventilátorem (7) a jeho propojovací spalinové potrubí (10) se sacím ventilátorem (8) a regulační klapkou (9) ústí do alespoň jedné trubky (12) s otvory (13) umístěné v násypce (2).
Patent CZ-66395-A3 (CZ)
Title: Imidazodiazepines
Inventor: GODEL THIERRY
IPC: A61P25/08
Filed: 1995-03-15
Abstract: Aminomethyl-substd. oxadiazolyl-imidazodiazepines of formula (I) and their addn salts are new: A and C atoms  alpha  and  beta form a gp of formula e.g. (A<1>):Q = a gp. of formula e.g. (Q<1>):R<1>, R<2> = H; lower alkyl,etc.;or NR<1>R<2> = 5-8 membered heterocycle opt. contg. a further hetero atom or carrying a fused benzene ring; R<3> = H and R<4> = lower alkyl; or R<3>+R<6> = H; halo;etc.; and C atom gamma  has the S configuration when R<3> is other than H.
Patent CZ-83599-A3 (CZ)
Title: Syringe
Inventor: HANSEN STEFFEN
IPC: A61M5/31
Filed: 1997-09-10
Abstract: A syringe comprising a housing (1), a dose setting mechanism in the housing, an injection button (6), and a needle receiving member. By this syringe doses of a medicine can be set by the dose setting mechanism and by operating the injection button (6) the set dose can be pressed out from an ampoule accommodated in the housing (1) through a needle (5) mounted on the needle receiving member. The housing further comprises an accessible compartment covered by a lid (10) or a cap (8) in which compartment accessories (11) are stored.
Patent SK-20199-A3 (SK)
Title: Ether muscarinic antagonists
Inventor: WANG YUGUANG
IPC: A61K31/4465
Filed: 1997-08-13
Abstract: 1,4 Di-substituted piperidine muscarinic antagonists of formula (I) or an isomer, pharmaceutically acceptable salt, ester or solvate thereof, wherein X is a bond, -O-, -S-, -SO-, -SO2-, -CO-, -C(OR<7>)2-, -CH2-O-, -O-CH2-, -CH=CH-, -CH2-, -CH(C1-C6 alkyl)-, -C(C1-C6 alkyl)2-, -CONR<17>-, -NR<17>CO-, -O-C(O)NR<17>-, -NR<17>C(O)-O-, -SO2NR<17>- or -NR<17>SO2-; R is cycloalkyl, optionally substituted phenyl or optionally substituted pyridyl; R<2> is H, alkyl, optionally substituted cycloalkyl, cycloalkenyl, t-butoxycarbonyl or optionally substituted piperidinyl; and the remaining variables are as defined in the specification, are disclosed. Compounds of formula (I) are useful for treating cognitive disorders such as Alzheimer's disease. Also disclosed are pharmaceutical compositions, methods of preparation and combinations of compounds of formula (I) with ACh'ase inhibitors.
Patent SK-33193-A3 (SK)
Title: High visible, low uv and low ir transmittance green glass composition
Inventor: BECKWITH STEVEN P
IPC: C03C4/08
Filed: 1993-04-09
Abstract: A soda-lime-silica green glass favoring the yellow side, rather than the bluish side of the spectrum, is produced having high visible transmittance, low infrared energy transmittance, low ultraviolet radiation transmittance, and low total solar energy transmittance by manipulating the reduction of iron (as Fe203) to Fe0 and the percent of these two oxides to achieve these characteristics without the use of Ce02 or other UV absorbing additives and by using conventional glass melting and refining apparatus. <IMAGE>
Patent SK-84197-A3 (SK)
Title: Manufacture of extruded articles
Inventor: GRAVESON IAN
IPC: B29C48/885
Filed: 1996-01-09
Abstract: A method of manufacturing extruded articles of lyocell is described wherein a solution of cellulose in a tertiary amine N-oxide is extruded by way of a die (2) through an air-gap (3) into a coagulating bath (5), air being supplied to and discharged from the air-gap (3), characterised in that the air-gap (3) comprises a first region (9) adjacent the face (2a) of the die (2) and a second region (12) more remote from the face (2a) of the die (2), the moisture content of the air supplied to the first region (9) being maintained at a lower value than the moisture content of the air supplied to the second region (12). The method provides improved spinnability and may provide lyocell filaments with a reduced tendency to fibrillation.
Patent CH-618063G-A3 (CH)
IPC: D06P5/24
Filed: 1975-06-13
Abstract: A method of transfer printing, wherein a release layer is formed on a temporary support; printing a pattern on said release layer with an ink containing coloring matter therein to obtain a transfer sheet; superposing an article to be transfer-printed on the printed surface of said transfer sheet; heating the superposed aggregate under pressure to transfer the release layer with the pattern onto said article to be transfer-printed; fixing the coloring matter to said article, and then soaping said article to remove the release layer, characterized in that the release layer consists of (1) 10-90 wt. percent of one or more thermoplastic polymers having excellent film-forming properties and water-solubility or alkaline water solubility as well as organic solvent solubility and (2) 90 to 10 wt. percent of one or more plasticizers having a melting point between 30 DEG  and 120 DEG  C selected from oxycarboxylic acids or their derivatives having water solubility or alkaline water solubility as well as organic solvent solubility.
Patent CZ-189193-A3 (CZ)
Title: Packaging system containing a small frame with an integrated lid, a bag and an external casing
Inventor: ALBANESI MARIO
IPC: B65D25/16
Filed: 1992-01-31
Abstract: For a packaging (1), consistant of an internal bag (2) containing for example a product preserved under vacuum, of an external container and of a small frame with integral lid (6) made of plastic material, an improved sticking system is described, which renders both said bag and the external container integral with the small frame itself. The adoption is envisaged of  reliefs on the lower wall of the flange (10) of the small frame, and of branched fins (30) arranged in the peripheral groove (12) of said small frame, into which the edge of the external container is inserted, in order to increase the surface area for adhesion, promote the distribution of the glue and to create barriers to the passage of air for the purpose of improving the hermetic sealing of the lid during the use of the packaging. The upper edge of the external container can also have a differently shaped configuration in order to improve adhesion.
Patent CZ-396292-A3 (CZ)
Title: Pharmaceutical preparation for treating and prophylaxis of infection
Inventor: WEIGOLD HELMUT
IPC: C01G49/04
Filed: 1991-06-28
Abstract: Heteropolytungstate compounds of general formulae (I), wherein M is Co, Fe, Zn, FeOA, FeO1/2; Cp represents an optionally substituted cyclopentadienyl residue; A is a monovalent or divalent cation or mixture of such cations; m is the number of cations necessary for electrical neutrality of the molecule; or pharmaceutically acceptable derivatives thereof. Pharmaceutical compositions or methods for the treatment or prophylaxis of retrovirus-associated infection which involve the use of such compounds.
Patent CZ-563490-A3 (CZ)
Title: Process for preparing taxol and oxazinone as intermediate for the preparation
Inventor: HOLTON ROBERT A DR
IPC: C07D413/00
Filed: 1990-11-14
Abstract: Process for the preparation of a taxol intermediate comprising contacting an alcohol with an oxazinone having the formula: <CHEM> wherein R1 is aryl, heteroaryl, alkyl, alkenyl, alkynyl or OR7 wherein R7 is alkyl, alkenyl, alkynyl, aryl or heteroaryl; R2 and R5 are independently selected from hydrogen, alkyl alkenyl, alkynyl, aryl, heteroaryl, and OR8 wherein R8 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, or hydroxyl protecting group; and R3 and R6 are independently selected from hydrogen, alkyl, alkenyl, alkynyl, aryl and heteroaryl.
Patent CZ-706388-A3 (CZ)
Title: Process for preparing 3-azido-1,2--propanediol
Inventor: STANEK JAN RNDR CSC
IPC: C07C247/04
Filed: 1988-10-25
Abstract: This method of producing 3-azido-1,2-propandiol is based on the fact that epichlorohydrine is exposed to water in the presence of 0.1 to 1% by weight of mineral acid according to the weight of the reaction mixture, and after adjusting the pH value to 6 to 8 the created product is exposed to sodium azide directly in the aqueous medium at a temperature of 70 to 100 degrees C.
Patent CZ-101097-A3 (CZ)
Title: Fusible conductor for fusible cut-outs
Inventor: FELCMAN PETR ING
IPC: H01H85/08
Filed: 1997-04-03
Abstract: Fusing conductor (1) for electrical safety fuses, containing at least one transverse row of fusing bridges (2), made by narrowed points between rows of holes (3) weakening the cross-section of the fusing conductor (1). The holes (3) are elliptical with a longer axis running in the longitudinal direction of the fusing conductor (1), whereas the ratio of longer axes to shorter axes of each elliptical hole (3) is between 1.2 and 2.2.<IMAGE>
Patent CZ-143593-A3 (CZ)
Inventor: BAUR PETER
IPC: B01D53/34
Filed: 1993-07-19
Abstract: Vodný roztok aditiva, zejména močoviny, se před zaváděním
do trysky (4) chladí na teplotu nižší než 15°. Mísící
nádrž (13) je opatřena přívodním zařízením (15) aditiva,
přívodním vedením (14) vody, přepouštčcím ventilem (18)
a výstupním vedením s dávkovacím čerpadlem (5), odpařovačem
(6), přístrojem (10) ke kontrole průtoku a uzavíracím
ventilem (12), které je zaústěno do trysky (4) umístěné
spolu s hořákem (2) ve stěně (3) kotle, v němž je vytvořen
plamenec (1). Dávkovači čerpadlo (5) je opatřeno hnacím
motorem (16) a servomotorem (17), jenž jsou spolu s hořákem
(2) napojeny na regulační přístroj (11). Do trysky (4)
je zaústěno zásobovací vedení (9) tlakového vzduchu s uzavíracím
ventilem (7). Odpařovač (6) může být umístěn v
mísící nádrži (13).
Patent CZ-161794-A3 (CZ)
Title: Vortex turbine
Inventor: KASPARIK BEDRICH ING
IPC: F03B1/00
Filed: 1994-07-04
Abstract: This vortex turbine consists of an input part which directs the flow of the working medium into the spiral channels with an axis identical to the axis of the rotor consisting of an outside shell (3) and an inside axial closure (4) connected to the shaft (5) and the gap between the outside shell (3) and the inside axial closure (4) is equipped with directional elements (6) for the flow of the medium in the direction from the axis of the rotor.<IMAGE>
Patent CZ-172295-A3 (CZ)
Title: N-phenyl-2-pyrimidamine derivatives, process of their preparation, pharmaceutical compositions containing thereof and their use
Inventor: ZIMMERMANN JURG
IPC: A61P25/02
Filed: 1994-09-21
Abstract: PCT No. PCT/EP94/03151 Sec. 371 Date May 31, 1995 Sec. 102(e) Date May 31, 1995 PCT Filed Sep. 21, 1994 PCT Pub. No. WO95/09853 PCT Pub. Date Apr. 13, 1993N-phenyl-2-pyrimidineamine derivatives of formula I    <IMAGE>  (I)  wherein the substituents are as defined in claim 1 and the derivatives of formula I can be used, for example, in the treatment of tumour diseases.
Patent CZ-179897-A3 (CZ)
Title: Process for preparing 1-2(-deoxy-2,2-difluoro-d-ribofuranosyl)- 4-aminopyrimidin-2-one hydrochloride
Inventor: BERGLUND RICHARD ALAN
IPC: C07H19/073
Filed: 1995-11-14
Abstract: This invention provides a process for preparing gemcitabine hydrochloride which comprises deblocking β-1-(2'-deoxy-2',2'-difluoro-3',5'-di-O-benzoyl-D-ribofuranosyl)-4-aminopyrimidin-2-one with a catalytic amount of an alkylamine in the presence of methanol or ethanol in an environment essentially free of water; treating the resulting solution with hydrochloric acid and an antisolvent; and recovering the resulting solid gemcitabine hydrochloride.
Patent CZ-185199-A3 (CZ)
Title: Derivatives of sulfinic acid , process of their preparation and use
Inventor: BERGHOFER JOSEF
IPC: C07C313/04
Filed: 1998-07-01
Abstract: The invention relates to sulphinic acid derivatives of formula (I) wherein the substituents have the meanings given in the Description. The inventive sulphinic acid compounds can be used as reducing agents which do not release formaldehyde.
Patent CZ-193495-A3 (CZ)
Title: The use of dehydroepiandrosterone derivatives for the preparation of a pharmaceutical preparation and pharmaceutical composition containing the derivative
Inventor: DAYNES RAYMOND A
IPC: A61P9/00
Filed: 1994-03-08
Abstract: PCT No. PCT/US94/02558 Sec. 371 Date Aug. 9, 1994 Sec. 102(e) Date Aug. 9, 1994 PCT Filed Mar. 8, 1994 PCT Pub. No. WO94/20111 PCT Pub. Date Sep. 15, 1994.The present invention is directed to a method for preventing or reducing ischemia following injury, such as reperfusion injury following ischemia, cellular damage associated with ischemic episodes, such as infarctions or traumatic injuries, and thus to prevent or reduce the consequent progressive necrosis of tissue associated with such ischemia. This effect is achieved by administering DHEA or DHEA derivatives to a patient as soon as possible after the injury. The present invention is further directed to methods for preventing or reducing bacterial translocation or adult respiratory distress syndrome in a patient. Similarly, bacterial translocation and adult respiratory distress syndrome are prevented or reduced by administering DHEA or DHEA derivatives to a patient. Suitable derivatives of DHEA include, among others, 16 alpha -bromo-DHEA, androstenediol and derivatives which have side chains at the 4' and/or 7' positions, which do not destroy the native activity of DHEA but which are capable of inhibiting sulfotransferase to prevent the conversion of DHEA to DHEA-S.
Patent CZ-199895-A3 (CZ)
Title: Pharmaceutical preparations containing cephaclor, dispersible tablets containing cephaclor and process for preparing thereof
Inventor: ARCE MENDIZABAL FLAVIA
IPC: A61K47/12
Filed: 1995-08-03
Abstract: Pharmaceutical formulations of cefaclor, suitable for the direct-compression manufacture of dispersible tablets, containing the antibiotic cefaclor in an amount between 35% and 50% by weight of the total weight of the formulation, along with suitable excipients and coadjuvants selected from disintegrators, diluents, lubricants, antiadherents, sweeteners, fragrances and, optionally, flavorings, opacifiers and colorants. Said formulations are suitable for the manufacture of dispersible tablets which disintegrate in less than three minutes in water at 19° - 21°C, and are suitable for the treatment of infections caused by bacteria strains sensitive to cefaclor.
Patent CZ-200088-A3 (CZ)
Inventor: CAVAZZA CLAUDIO
IPC: A61P15/12
Filed: 1998-07-10
Abstract: Přípravek pro zdravotní výživu vhodný ke zlepšení a léčbě
stavů neklidu způsobeného stresemsestává z následující
kombinace, (a) Lkamitin nebo alkanoyl-L-kamitin; (b) směs
přírodních rostlinných přípravků; (c) sójový lecitin; (d)
kyselinajablečná. Přírodní přípravkyjsou vybrány výhodně ze
skupiny sestávající z přírodního extraktu Coiynanthe yohimbe
nebo yohimbinu, přírodního extraktu Panax ginsenga,
přírodního extraktu Paullinia cupana nabo guarany a
přírodního extraktu Turnéra diffiisa nebo damianu.
Patent CZ-202199-A3 (CZ)
Inventor: MAŠÁN VLADIMÍR
IPC: A23L21/15
Filed: 2021-03-04
Abstract: Při způsobu výroby rakytníkové pomazánky se nejprve hrubé kaly vzniklé při výrobě rakytníkového moštu a/nebo jemné kaly vzniklé při výrobě rakytníkového vína zahřejí na teplotu v rozmezí od 80 do 100 °C; k zahřátým kalům se přidá želírovací činidlo v množství od 2 do 30 g na 1 kg kalů, a popřípadě cukr v množství od 20 do 150 g na 1 kg kalů; výsledná směs se udržuje na teplotě v rozmezí od 80 do 100 °C po dobu alespoň 5 minut; následně se ke směsi přidá cukr v množství od 300 g do 1000 g na 1 kg kalů a směs se přivede k varu a vaří po dobu alespoň 3 minut. Rakytníková pomazánky z kvasničných kalů, vzniklých při výrobě vína umožnuje využití sekundárních produktů kvasného procesu (kalů) k produkci pokrmu se zlepšenými dietetickými a výživovými vlastnostmi.
Patent CZ-241097-A3 (CZ)
Title: Insecticidal combination containing insecticide being selected from the group of chloronicotinyls and insecticide with pyrazole, parrole or phenylimidazole group
Inventor: MEUNIER LUCIEN
IPC: A01N43/50
Filed: 1996-01-26
Abstract: Agrochemical combinations including an effective amount of an insecticide which includes an insecticide from the chloronicotinyl family A such as imidacloprid, acetamiprid or nitenpyram, and an insecticide B having a pyrazole, pyrrole or phenylimidazole group; compositions containing one or both of said two active substances; and a method for treating and protecting plants, and seeds in particular, from insects or arthropods, by applying a combination of both active substances, are disclosed. A composition containing both active substances may also be applied. Alternatively, two compositions each containing one of the two active substances may be applied simultaneously or sequentially to ensure a combined effect.
Patent CZ-253498-A3 (CZ)
Title: Modification of 1-(2,6-difluorobenzyl)-1h-1,2,3-triazole-4-carboxamide, pharmaceutical compositions in which it is comprised and the use thereof
Inventor: PORTMANN ROBERT
IPC: C07D249/04
Filed: 1998-06-08
Abstract: The invention relates to the novel modification A or A' of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide of formula (I), its use for the treatment of epilepsy, and pharmaceutical preparations comprising this crystal modification.
Patent CZ-268098-A3 (CZ)
Title: Process for preparing polyester yarn
Inventor: GEIER RUDOLF DIPL ING
IPC: D01D5/04
Filed: 1998-08-21
Abstract: The production process for melt-spun polyester filaments (8) has a preliminary drawing action through a counter flow at a temp. of 100-199 degrees C and preferably 120-170 degrees C to develop a crystallinity of ≥ 24%.
Patent CZ-280697-A3 (CZ)
Title: 6-ARYL-PYRAZOLO(3,4-d)PYRIMIDIN-4-ONES, COMPOSITIONS CONTAINING THEREOF AND THEIR USE
Inventor: BACON EDWARD R
IPC: A61P9/12
Filed: 1996-03-05
Abstract: 6-Aryl pyrazolo[3,4-d]pyrimidin-4-one derivatives, pharmaceutical compositions containing them and methods for effecting c-GMP-phosphodiesterase inhibition and for treating heart failure and/or hypertension.
Patent CZ-282497-A3 (CZ)
Title: Amino acid-hydroxyethylaminosulfoamide inhibitors of retrovirus protease
Inventor: GETMAN DANIEL P
IPC: A61P31/12
Filed: 1996-03-07
Abstract: Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.