Patent SG-11201808227Y-A (SG)
Title: Methods of vitamin d treatment
Inventor: MELNICK JOEL Z
IPC: A61K31/593
Filed: 2017-03-28
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1 Ill 11111 0 11101 010 11111 010 1111 1 0 I Ell 0111 0111 00111111110 11110E111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2017/182237 Al 26 October 2017 (26.10.2017) WIPO I PCT (51) International Patent Classification: (74) Agent: JOHNSON, Yvonne Catherine; Barker Brettell A61K 31/592 (2006.01) A61P 3/02 (2006.01) LLP, 100 Hagley Road, Edgbaston, Birmingham West Mid- A61K 31/593 (2006.01) A61P 13/12 (2006.01) lands B16 8QQ (GB). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/EP2017/057282 kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 28 March 2017 (28.03.2017) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (25) Filing Language: English HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, (26) Publication Language: English KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (30) Priority Data: PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, 62/314,359 28 March 2016 (28.03.2016) US SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: OPKO IRELAND GLOBAL HOLDINGS, LIMITED [IE/ ]; 10 Market St., #721, Camana Bay, KY1 (84) Designated States (unless otherwise indicated, for every 9006 (KY). kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (72) Inventors: MELNICK, Joel Z.; 7600 Collins Avenue, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Apt.718, Miami Beach, Florida 33141 (US). BISHOP, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Charles W.; 7741 Collins Avenue, Miami Beach, Florida — EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 33141 (US). PETKOVICH, P. Martin; 35 Lakeland Point MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = Drive, Kingston, Ontario K7M 4E8 (CA). STRUGNELL, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Stephen A.; 10180 West Bay Harbor Drive, Apt 3A, Bay KM, ML, MR, NE, SN, TD, TG). Harbor Islands, Florida 33154 (US). = (54) Title: = - = = = 2 = = METHODS OF VITAMIN D TREATMENT (57) : Methods for treating vitamin D insufficiency and secondary hyperparathyroidism in patients having CKD comprising administering re- peat doses of 25-hydroxyvitamin D are disclosed. The methods comprise administering 25-hydroxyvitamin D in an amount effective to safely raise the patient's serum 25-hydroxyvitamin D level to greater than 90 ng/ml and/ or to control the patient's serum ratio of 25-hydroxyvitamin D to 24,25- dihydroxyvitamin D to less than 20. = = - 11 IN en ei , Weeks of Treatment F1GLRE1A 1 p o ei p . . . ,, ,„........... Il Wee. of Treatment Ir...' FIGURE 1B 11 © ei C [Continued on next page] WO 2017/182237 Al MIDEDIMOMMIONMEMOMMOIMOIIIINHINVOIMIE Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event amendments (Rule 48.2(h)) of receipt of