baber/WOPTO huggingface dataset:
Patent DE-3783577-T2 (DE)
Inventor: KANEKO TAKUSHI
IPC: C07H19/044
Filed: 1987-11-20
Granted: 1993-05-19
Abstract: There are disclosed analogs of the antitumor agent, rebeccamycin, having the formula <CHEM>  wherein:  n is an integer from 1 to 6; A<6> and A<1><3> are selected from H and -(CH2)nNR<1>R<2> and at least one of A<6> and A<1><3> is -(CH2)n-NR<1>R<2>; R<1> and R<2>, independently, are selected from hydrogen, unsubstituted and substituted C1-C6 alkyl, aralkyl having 1 to 3 carbons in the alkyl moiety and unsubstituted phenyl or phenyl substituted with 1 to 3 alkyl, alkoxy, hydroxy, halo, carboxyl, alkoxycarbonyl, and amino and mono- and di-lower-alkylamino groups in the aryl moiety, and aryl selected from unsubstituted phenyl and phenyl substituted with 1 to 3 alkyl, alkoxy, hydroxy, halo, amino, mono- and dialkylamino, nitro, carboxyl, alkoxycarbonyl, and cyano groups provided that both R<1> and R<2> are not each aryl and, when taken together, R<1> and R<2> may be selected from -(CH2)4- and (CH2)2-R<3>-(CH2)2- to form a 5- or 6-membered ring together with the N-atom wherein R<3> is selected from CH2, NH, O and S; X is selected from H, F, Cl, Br, C1-C3 alkyl, OH, carboxyl, alkoxycarbonyl and alkoxy wherein the alkyl moiety is C1-C3 alkyl, benzyloxy, amino, and mono- and dialkylamino; and R<4> is selected from H and CH3; and pharmaceutically acceptable acid addition and base salts thereof. The compounds possess antineoplastic properties against mammalian, particularly experimental animal, tumor systems. The compounds of the invention are aminoalkylated derivatives of rebeccamycin produced by first reacting rebeccamycin with a strong base to obtain a reactive intermediate and then reacting the reactive intermediate with an aminoalkyl compound.
Patent DE-3851171-T2 (DE)
Inventor: GROSSE MAURICE
IPC: G09F11/32
Filed: 1988-04-06
Granted: 1995-04-06
Abstract: Display device comprising shaped guide plates (44) positively guiding the suspension rods (4) of viewing sheets (3) around a roller (8) when each suspension rod (4) is engaged by cradles (11) carried by electrically driven chains (10). A strap (50) which is rendered resilient by the inclusion therein of a spring (53) extends centrally down the rear of the device and prevents the successive suspension rods (4) from becoming detached from the cradles (11) in this region. A gate which includes a stop (55) is provided at the foot of ramps (5) upon which the rods (4) are stacked to ensure that the rods will not become bunched or otherwise entangled on the ramps (5) and that the cradles (11) will positively pick up only one suspension rod (4) at each passage past the gate. A time delay switch (56) is associated with a microswitch (41) and will close to bypass switch (41), after a predetemined interval of time, so that the drive of the device may re-start even if the power supply to the device had previously been switched off with the microswitch (41) in its open circuit position. Each rectangular display sheet (3) preferably comprises two layers which are secured to one another at the edges which coincide with the suspension rods (4) and along one of two longitudinal edges. The other edge is open except for two relatively short portions that are joined together at its opposite ends, whereby webs carrying indicia may be entered between the layers, by appropriate flexing, and will remain trapped therebetween by the short joined together edge portions of the two layers.
Patent DE-3853224-T2 (DE)
Inventor: BRANDON MALCOLM ROY
IPC: C07K1/18
Filed: 1988-04-21
Granted: 1995-06-29
Abstract: For the preparation of a protein in a physiologically active or native form, a source of protein in a solubilised form is contacted with cationic exchange medium which may be a cationic exchange resin which generates a rapid ion exchange rate. The cationic exchange resin may be provided in the form of a cationic exchange chromatography column, the source of protein being contacted therewith via elution of the chromatography column. The protein is then recovered in a physiologically active form. This represents a highly efficient, and hence cost effective, method for the recovery of proteins.
Patent DE-3854487-T2 (DE)
Inventor: BACHOT JEAN
IPC: C25B11/04
Filed: 1988-06-13
Granted: 1996-05-09
Abstract: An electroactivated material comprising fibres at least part of which is electrically conductive and a binder chosen from fluoropolymers, the said material exhibiting a resistivity lower than 0.4 ohm cm and being characterised in that it comprises at least one electrocatalytic agent uniformly distributed in its bulk, the said agent being chosen from the group consisting of Raney metals and Raney alloys from which most of the easily removable metal(s) and alloys thereof have been removed. 
<??>The invention also relates to composite materials formed by the combination of at least one electroactivated material and of an elementary cathode consisting of a metal surface, assembled with a diaphragm if appropriate, and a process for the manufacture of the said materials. 
<??>These materials can be employed especially in a cell for the electrolysis of sodium chloride.
Patent DE-3873041-T2 (DE)
Inventor: JANSEN ADOLF ERIC
IPC: G01N1/20
Filed: 1988-11-22
Granted: 1992-12-03
Abstract: By mounting in the hood (2) of a sampler a sleeve (3) reciprocable by means of a bottle (27) or bottle retainer that can be sealed by means of a septum (14), the option is created to sterilize, in a simple manner, the needle(s) (6,8) prior to and/or after sampling. In a special embodiment of the sampler it is possible to sterilize the needle(s) after sampling and before the needle(s) contact(s) the ambient air.
Patent DE-3881519-T2 (DE)
Inventor: BLANKENSHIP ERNEST
IPC: A47K11/02
Filed: 1988-08-29
Granted: 1993-09-30
Abstract: The incinerator toilet has an incinerator chamber with an opening formed therethrough in which is located an electrical heating coil. A bowl is located above the chamber and a removable pan located below the chamber. The chamber is formed by inner and outer walls with a catalyst container being integral therewith and extending radially outward to an increased depth. A heat activated catalyst is located in the catalyst chamber and perforations are formed through the inner and outer walls of the catalyst chamber. A collection chamber is located outwardly of the catalyst chamber and has a lower outlet to which is coupled an exhaust device for drawing gases from the incinerator chamber through the heat activated catalyst and collection chamber. A baffle is located in the collection chamber and is coupled to its lower wall and extends upward to a position above the outlet of the collection chamber. A top wall is secured above the catalyst chamber and the collection chamber and has an opening with a removable lid in fluid communication with both the catalyst chamber and the collection chamber.
Patent TR-199801753-T2 (TR)
Inventor: HIMMELSBACH FRANK
IPC: A61P43/00
Filed: 1997-03-03
Abstract: Isbu bulus genel Formül (I)'e ait Pirimido (5,4-d) Pirimidin'i, ki burada A2, A4, A6 ve A8 istem 1'de tanimlandigi gibidir, tautomerlerini, stereoizomerlerini ve tuzlarini, özellikle degerli farmako-lojik özellikler gösteren inorganik veya organik asit veya bazlarini içeren fizyolojik uyumlu tuzlarini, özellikle Tirosinkinaz tarafindan gelen sinyal transdüksiyonunu inhibisyon etkisini, hastaliklari iyilestirmedeki kullanimini, özellikle tümör hastaliklari, ve bunlarin üretimini konu alir.
Patent TR-199801801-T2 (TR)
Inventor: BEASLEY CHARLES MERRITT
IPC: A61P25/36
Filed: 1997-03-10
Abstract: The invention provides a method for treating substance abuse comprising administering an effective amount of olanzapine or pharmaceutically acceptable salt thereof to a patient in need thereof.
Patent TR-199900492-T2 (TR)
Title: Bakteri olusumunun önlenmesi.
Inventor: CLOVER RAINER
IPC: C09D5/14
Filed: 1996-06-05
Abstract: Bulus, bakteri olusumunu, özellikle kaplanmis bir alt tabaka üzerinde bakteri olusumunu önlemek için bir düzenleme saglanmaktadir. Bulus, bir biyosid içeren oldukça kuru bir toz kaplama terkibi olusturulmasi için toz kaplama terkibinin, alt tabaka üzerinde bir kaplama tabakasi olusturacak sekilde uygulanmasi için bir yöntem içerir; ve biyosid kaplama içinde de etkili biyosidal  aktivitesini koruyabilir.
Patent TR-199900556-T2 (TR)
Inventor: ENGEL JUERGEN
IPC: A61K38/04
Filed: 1997-09-01
Abstract: Bu bulus, bir memeli organizmada, testesteron  seviyelerini hadimlik araligina düsürmeden, selim prostat hiperplazisini ve prostat kanserini terapötik olarak kontrol etmek için kullanilabilen bir farmasötik terkip ile ilgili olup, bu terkip tek basina veya alfa -redüktaz inhibitörleri veya reseptör bloke edici maddelerle kombinasyon halinde  bir LH-RH antagonisti ihtiva eder.
Patent TR-199901394-T2 (TR)
Inventor: HARRIS ALAN RICHARD
IPC: C07C231/12
Filed: 1997-12-12
Abstract: Bu bulus ilaç olarak yararli olan formül (I)'in bilinen amin bilesimlerinin üretimi için gelistirilmis bir islem ile ilgilidir; burada R1 ve R2 bagimsiz olarak fenil ya da 4-florofenildir; R3 hidrojen, alkil C1-4 ya da metoksikarbonildir; R4 hidrojen ya da metildir; islem formül (II)'nin bir bilesiminin R5, R6, R7, R8, R9 ve R10'un bagimsiz olarak C1-6 alkil oldugu formül (III)'nin bir bilesimi ile, reaksiyonu ve onu takiben korumanin kaldirilmasi ve istege bagli olarak daha sonra farmasötik olarak uygun bir tuzun olusturulmasini içerir.
Patent DE-60002061-T2 (DE)
Inventor: HASZLER JOHANN
IPC: C22C21/06
Filed: 2000-05-04
Granted: 2004-02-12
Abstract: Aluminum-magnesium alloy product for welded mechanical construction, having the following composition, in weight percent: Mg 3.5-6.0, Mn 0.4-1.2, Zn 0.4-1.5, Zr 0.25 max., Cr 0.3 max., Ti 0.2 max., Fe 0.5 max., Si 0.5 max., Cu 0.4 max.; one or more selected from the group: Bi 0.005-0.1, Pb 0.005-0.1, Sn 0.01-0.1, Ag 0.01-0.5, Sc 0.01-0.5, Li 0.01-0.5, V 0.01-0.3, Ce 0.01-0.3, Y 0.01-0.3, and Ni 0.01-0.3; others (each) 0.05 max., (total) 0.15 max.; and balance aluminum.
Patent DE-60003188-T2 (DE)
Inventor: VITANYINE MORVAI MAGDOLNA
IPC: A61K31/00
Filed: 2000-07-28
Granted: 2004-07-01
Abstract: The invention relates to a stable, solid pharmaceutical composition comprising as active ingredients paracetamol and drotaverine hydrochloride in a mixture with one or more organic acid or potassium sorbate as stabilizers, one or more usually used pharmaceutical auxiliary materials and optionally additional active ingredient. As additional active ingredient codein phosphate may be used.
Patent DE-60003199-T2 (DE)
Inventor: MUELLENBORN MATTHIAS
IPC: H04R19/00
Filed: 2000-09-06
Granted: 2004-07-01
Abstract: The present invention relates to solid state silicon-based condenser microphone systems suitable for batch production. The combination of the different elements forming the microphone system is more flexible compared to any other system disclosed in the prior art. Electrical connections between the different elements of the microphone system are established economically and reliably via a silicon carrier using flip-chip technology. The invention uses an integrated electronic circuit chip, preferably an application specific integrated circuit (ASIC) which may be designed and manufactured separately and independent of the design and manufacture of the transducer element of the microphone. The complete sensor system can be electrically connected to an external substrate by surface mount technology with the contacts facing one side of the system that is not in conflict with the above-mentioned interface to the environment. This allows the user to apply simple and efficient surface mount techniques for the assembly of the overall system.
Patent DE-60005236-T2 (DE)
Inventor: KEMPER DIMITRI WASIL
IPC: F16B37/04
Filed: 2000-03-14
Granted: 2004-07-01
Abstract: The invention describes a mounting system comprising a profiled section (2) which is C-shaped in cross section and is provided with an assembly opening (7) and an mounting element which is able to interact with the profiled section (2). The mounting element comprises a support part (3) which can be introduced into the interior of the profiled section (3) via the assembly opening (7). The support part (3) can be rotated inside the profiled section (2), so that it spans the width of the assembly opening (7). A separate intermediate part (4) is non-rotatably connected to the support part (3). On its side directed away from the support part (3), the intermediate part (4) is connected to a clamping part (5) and is provided with a spring element which acts between the intermediate part (4) and the support part (3), the spring element bearing against the support part (3) and exerting a force thereon which tends to press the support part (3) and the intermediate part (4) apart. <IMAGE>
Patent DE-60005480-T2 (DE)
Inventor: SCHMITZ JOHANN
IPC: A61F13/472
Filed: 2000-01-12
Granted: 2004-07-01
Abstract: The present invention relates to an apparatus for applying discrete portions (10) of a web material onto a receiving web (7), comprising:     a primary axis of rotation and an attachment zone at an average radial distance, R1, from the primary axis of rotation; transfer elements (6) rotatable about the primary axis, the transfer elements receiving a second web (2) at a radial distance, R2, from the primary axis wherein the radial distance R1 is greater than the radial distance R2; a means for displacing the transfer elements (6) so that the second web (2) is moved immediately adjacent to the attachment zone; and an attachment surface (10) rotatable about the primary axis and through the attachment zone, for transporting the receiving web (7) about the primary axis, whereby discrete portions (10) of the second web (2) are attached to the receiving web (7) in the attachment zone, forming a composite web comprising the receiving web (7) and discrete portions (10) of the second web (2).   The present invention also relates to a process for applying discrete portions (10) of a web material onto a receiving web (7), using said apparatus. <IMAGE>
Patent DE-60007334-T2 (DE)
Inventor: KNIGHTS D
IPC: H01M10/42
Filed: 2000-08-23
Granted: 2004-10-21
Abstract: In a solid polymer fuel cell series, various circumstances can result in the fuel cell being driven into voltage reversal. For instance, cell voltage reversal can occur if that cell receives an inadequate supply of fuel (for example, fuel starvation). In order to pass current during fuel starvation, reactions other than fuel oxidation may take place at the fuel cell anode, including water electrolysis and oxidation of anode components. The latter may result in significant degradation of the anode. Such fuel cells can be made more tolerant to cell reversal by promoting water electrolysis over anode component oxidation at the anode. This can be accomplished by incorporating a catalyst composition at the anode to promote the water electrolysis reaction, in addition to the typical anode electrocatalyst for promoting fuel oxidation.
Patent DE-60009496-T2 (DE)
Inventor: SAULSBURY ASHLEY
IPC: G06F9/46
Filed: 2000-04-14
Granted: 2005-03-24
Abstract: A microprocessor with reduced context switching overhead and a corresponding method is disclosed. The microprocessor comprises a working register file that comprises dirty bit registers and working registers. The working registers including one or more corresponding working registers for each of the dirty bit registers. The microprocessor also comprises a decoder unit that is configured to decode an instruction that has a dirty bit register field specifying a selected dirty bit register of the dirty bit registers. The decoder unit is configured to generate decode signals in response. Furthermore, the working register file is configured to cause the selected dirty bit register to store a new dirty bit in response to the decode signals. The new dirty bit indicates that each operand stored by the one or more corresponding working registers is inactive and no longer needs to be saved to memory if a new context switch occurs.
Patent DE-60010861-T2 (DE)
Inventor: DREYFUS JEAN-MICHEL
IPC: C04B35/52
Filed: 2000-02-01
Granted: 2004-11-04
Abstract: In this cathode, which is a single block, the electrical resistivity is heterogeneous along its longitudinal axis, this resistivity being higher in the end regions of the cathode (3) than in the central region of the latter.
Patent DE-60013543-T2 (DE)
Inventor: DECELLES GILLES
IPC: B65D55/02
Filed: 2000-06-06
Granted: 2005-09-29
Abstract: A dual tamper evident closure (1) for sealing the neck portion of a container (3). The closure (1) which is preferably made of one single piece of plastic material, has a body (15) with a skirt (17) sized and shaped to fit onto and be screwed or otherwise detachably fixed to the neck portion (5). The body (15) also has a top surface (25) with an opening (27) in registry with the outlet of the neck portion. The closure also has a cap (29) that is connected to the closure body (15) by a hinge (35) and is sized and shaped to cover the opening (27) of the body (15) and thus to close the outlet of the neck portion when folded down in a closed position. A tamper evident band (37) in the form of a ring is connected by frangible bridges (39) to the lower edge of the skirt (17) of the body (15). This band (37) is provided with hooks (41) designed to cooperate with an annular bead projecting from the neck portion in order to rigidly retain the body onto the neck portion. A tear tab (43) integrally projects from the peripheral edge of the closure cap in a position that is opposite to the hinge (35). This tear tab (43) has an upper end that is connected by a frangible bridge (45) to the peripheral edge of the closure cap (29), and a lower end (47) that is rigidly connected to the tamper evident band (37). In use, the tear tab (43) as long as it remains connected to the closure cap (29), warrants that the closure cap (29) has not been lifted up and thus the container (3) has not been opened.
Patent DE-60019774-T2 (DE)
Inventor: BOSCH WILLIAM
IPC: A61K8/73
Filed: 2000-10-05
Granted: 2006-03-09
Abstract: Bioadhesive nanoparticulate compositions, comprising active agent particles and one or more cationic surface stabilizers, are described. The cationic surface stabilizers prevent aggregation of the nanoparticles and increase bioadhesion of the nanoparticles to biological substrates, such as an insect, teeth, bone, nails, chitin, feathers, scales, mucous, skin, hair, plant tissue, etc. The particles may consist of pharmacologically active compounds (e.g., drug compounds for human or veterinary use), agricultural chemicals (pesticides, herbicides, fertilizers, and the like), cosmetic agents, consumer products (coloring agents, flavors, or fragrances), or other materials which function by interacting with biological substrates. In addition, the invention relates to methods of preparing and using such bioadhesive nanoparticulate compositions.
Patent DE-60023693-T2 (DE)
Inventor: MARCOS ANA TERESA
IPC: C12P23/00
Filed: 2000-06-06
Granted: 2006-07-20
Abstract: Process for the production of lycopene. The present invention refers to a new process of obtaining carotenoids, especially such as Blakeslea. A fermentation method is described which allows obtaining an increase in the production of lycopene, based on the addition of trisporic acids. The process is performed starting from wild strains or mutants of them, in single or mixed culture. The addition of trisporic acids can take place at the start of or during fermentation and their origin can be a partially purified preparation or a non-purified source of them.
Patent DE-60026319-T2 (DE)
Inventor: DEL PESCO WAYNE
IPC: C09K3/18
Filed: 2000-08-09
Granted: 2006-11-30
Abstract: A polymer having at least one urea linkage derived by contacting (1) at least one polyisocyanate, or mixture of polyisocyanates, (2) at least one fluorocarbon alcohol, fluorocarbon thiol or fluorocarbon amine, (3) at least one straight or branched chain alcohol, amine or thiol, and (4) at least one alcohol containing a sulfonic acid group or its salt, and then (5) optionally at least one linking agent useful for imparting oil repellency and water repellency to substrates.
Patent DE-60026460-T2 (DE)
Inventor: TAKEUCHI NAOHITO
IPC: D06M11/79
Filed: 2000-10-03
Granted: 2006-10-12
Abstract: A water-decomposable fibrous sheet includes water-dispersible fibers having a fiber length of at most 20 mm, and a gel compound.
Patent DE-60027586-T2 (DE)
Inventor: ROBERTS A
IPC: H01M8/04
Filed: 2000-09-22
Granted: 2007-04-26
Abstract: Temperature dependent methods can be used to improve the cold start capability of fuel cell electric power generation systems. A method of ceasing operation of an electric power generation system improves the cold start capability and freeze tolerance of a fuel cell stack by reducing the amount of water remaining within the passages of the stack. The method involves purging one or more of the fuel cell stack oxidant and fuel passages at shutdown prior to allowing the fuel cell stack to drop to temperatures below the freezing point of water. Preferably purging at shutdown is conducted at a temperature below the stack operating temperature. Another method, used at start-up, involves directing a coolant fluid stream to the fuel cell stack only after a predetermined temperature above the freezing temperature of water is exceeded. Preferably, after freezing the fuel cell stack is heated to a temperature above its normal operating temperature before operation is commenced.
Patent DE-60029212-T2 (DE)
Inventor: FRATTINI L
IPC: G21F9/00
Filed: 2000-04-07
Granted: 2007-06-14
Abstract: An apparatus for cleaning an irradiated nuclear fuel assembly includes a housing adapted to engage a nuclear fuel assembly. A set of ultrasonic transducers is positioned on the housing to supply radially emanating omnidirectional ultrasonic energy to remove deposits from the nuclear fuel assembly.
Patent DE-60030567-T2 (DE)
Inventor: FISHMAN PNINA
IPC: A61P35/04
Filed: 2000-07-06
Granted: 2007-05-31
Abstract: The present invention relates to a composition of matter having the following characteristics: (i) it is derived from muscle tissue; (ii) it filters through a filler with a maximal molecular weight cut-off of about 10,000 Dalton, preferably less than 3,000 Daltons; and (iii) it has a biological effect of inhibiting proliferation of tumor cells and stimulation of proliferation of leukocytes and neutrophils; and to a method for preparing said composition of matter.Furthermore, the invention relates to pharmaceutical and neutraceutical preparations comprising the composition of matter disclosed herein. According to one embodiment, the pharmaceutical preparation is intended for treating or preventing cancer. The pharmaceutical preparations according to yet a further embodiment may be used for increasing the efficacy of a cytotoxic drug towards target cells, the target cells, being, for example, cancer cells. The pharmaceutical preparations may be administered parentally, however, are preferably administered orally.
Patent DE-60032316-T2 (DE)
Inventor: BORRESEN HARALD
IPC: A61F13/53
Filed: 2000-10-24
Granted: 2007-07-05
Abstract: A unit (1) for making pre-shaped absorbent pads (2) for sanitary items is equipped with a continuous conveyor belt (4) with an operating branch (4a) which defines a line (L1) for pad (2) forming and feed; the branch (4a) extends along a straight path (P), along which there are three successive stations (20a, 24, 20b) for feeding absorbent material (18, 25) and a plurality of seats (16) designed to accept and retain a given quantity of the absorbent material (18, 25). <IMAGE>