Patent SG-11201900744S-A (SG)
Title: Fc engineered anti-tnfr superfamily member antibodies having enhanced agonistic activity and methods of using them
Inventor: CHIU MARK
IPC: C07K16/40
Filed: 2017-08-04
Abstract: OX tend 0.9 OX405F2IgG1 0.8 An DX405621661 + protein G beads E 0.6 0.1 33 100 333 1000 Reagent (nghnl) Figure 111. • HEK-Blue. OX40 cells -A- HEK-Blue 0X40 cells +Raji cells 1000 Reagent (nghnl) W O 20 18/03 1400 Al 40 20 10 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 15 February 2018 (15.02.2018) WIP0 I PCT °mons °nolo III ium VIII iflo oimIE (10) International Publication Number WO 2018/031400 Al (51) International Patent Classification: C07K 16/12 (2006.01) C07K 16/40 (2006.01) CO7K 16/28 (2006.01) (21) International Application Number: PCT/US2017/045466 (22) International Filing Date: 04 August 2017 (04.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/374,347 12 August 2016 (12.08.2016) US (71) Applicant: JANSSEN BIOTECH, INC. [US/US]; 800/850 Ridgeview Drive, Horsham, Pennsylvania 19044 (US). (72) Inventors: CHIU, Mark; 1400 McKean Road, Spring House, Pennsylvania 19044 (US). ZHANG, Di; 1400 McK- ean Road, Spring House, Pennsylvania 19477 (US). (74) Agent: SHIRTZ, Joseph F. et al.; JOHNSON & JOHNSON, One Johnson & Johnson Plaza, New Brunswick, New Jersey 08933 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: FC ENGINEERED ANTI-TNFR SUPERFAMILY MEMBER ANTIBODIES HAVING ENHANCED AGONISTIC AC- TIVITY AND METHODS OF USING THEM Figure IA (57) : The present invention relates to engineered anti-TNFR superfamily member antibodies having enhanced agonistic activity and methods of using them. [Continued on next page] WO 2018/031400 Al MIDEDIMOMMIDIREIEHEIOMOEMONEMOVOIS Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))