baber/WOPTO huggingface dataset:
Patent WO-2020243373-A1 (WO)
Inventor: NARAYANAN RAMESH
IPC: C07C237/20
Filed: 2020-05-28
Abstract: This invention is directed to pyrrole, pyrazole, imidazole, triazole, and morpholine based selective androgen receptor degrader (SARD) compounds including cyclic and heterocyclic anilide rings and their synthetic precursors, and mono-, di-, or multi-substituted N-heterocyclic rings, R-isomers, non-hydroxylated and/or non-chiral propanamides in treating androgen receptor dependent diseases and conditions such as hyperproliferations of the prostate including pre-malignancies and benign prostatic hyperplasia, prostate cancer, advanced prostate cancer, castration resistant prostate cancer, triple negative breast cancer, other cancers expressing the androgen receptor, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.
Patent WO-2021025758-A1 (WO)
Inventor: SHUEY JEFFREY MATTHEW
IPC: G06F11/07
Filed: 2020-06-08
Abstract: A computer system includes a bus interface having error correction capability. The bus interface includes an error register that is configured to provide error information related to correctable errors. System software within the computer system is configured to obtain the error information from the error register and calculate a bit error metric based on the error information. A baseboard management controller within the computer system is configured to take an action in response to obtaining the bit error metric from the system software and determining that a condition related to the bit error metric has been satisfied.
Patent WO-2020257095-A1 (WO)
Inventor: MADSEN ERIC
IPC: C23C16/455
Filed: 2020-06-15
Abstract: A substrate support for a substrate processing system includes a baseplate, a ceramic layer arranged on the baseplate, and a carrier ring arranged on the ceramic layer. The ceramic layer has a first outer diameter, the carrier ring has a second outer diameter that is less than the first outer diameter, the ceramic layer includes a shoulder that extends from the second outer diameter of the carrier ring to the first outer diameter, and the shoulder slopes downward toward the first outer diameter.
Patent WO-2020257526-A1 (WO)
Title: Mats de fibres non tissés légers
Inventor: SITERS KEVIN E
IPC: H01M10/06
Filed: 2020-06-18
Abstract: Les mats de fibres non tissés comprennent principalement des fibres de verre B, et ont une épaisseur d'environ 10 à environ 700 microns et un poids de base d'environ 1 à 70 g/m2. Les mats sont généralement thermiquement stables à des températures allant jusqu'à 650 °C, et sont appropriés pour être utilisés en tant que séparateurs de batterie.
Patent WO-2021007545-A1 (WO)
Title: Mixtures comprising indazole pesticides
Inventor: ZHANG WENMING
IPC: A01N63/00
Filed: 2020-07-10
Abstract: Disclosed are compositions comprising compounds of Formula (I) and compounds of Formula (II). Also disclosed are compositions containing compounds of Formula (I) or compounds of Formula (II), or combinations thereof and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the disclosure.
Patent WO-2021040925-A1 (WO)
Title: Screening method, device, and kit for detecting mucosal carbohydrates and associated conditions
Inventor: SHAMSUDDIN ABULKALAM
IPC: G01N33/53
Filed: 2020-07-24
Abstract: This disclosure relates to a screening test method, device, and kit for mucosal carbohydrates and associated conditions including, cancerous and precancerous conditions. Specifically, the method tests abnormal carbohydrates in mucus or body fluid using reagents of galactose oxidase, and Schiffs Reagent. The screening test method, device, and kit provides improved accuracy, and minimizes handling procedures. This disclosure further relates to the use of the device or kit in a medical facility for an initial evaluation for cancerous and precancerous conditions.
Patent WO-2021022230-A1 (WO)
Title: Support de support de fil
Inventor: KORCZ KRZYSZTOF
IPC: H02G3/12
Filed: 2020-07-31
Abstract: Un support est prévu pour supporter un conducteur électrique s'étendant à travers une ouverture d'un boîtier électrique. Le support comprend une première partie conçue pour être couplée à une surface extérieure du boîtier électrique ; et une seconde partie couplée à la première partie et pouvant pivoter par rapport à la première partie. La seconde partie comprend une patte et une pluralité de languettes, et les languettes peuvent pivoter par rapport à la partie de liaison.
Patent WO-2021026083-A1 (WO)
Inventor: PICHARA KARIM
IPC: G06F3/0481
Filed: 2020-08-03
Abstract: Techniques to generate a flavor profile using artificial intelligence are disclosed. A flavor classifier classifies flavors for a given set of ingredients of a recipe from a set of possible classes of flavors. The flavor classifier may use different deep learning models to allow for different granularity levels corresponding to each flavor based on desired preciseness with classification of a particular flavor. A respective flavor predictor may or may not be used for each granularity level based on output of a certainty level classifier used for determining a preceding level of granularity.
Patent WO-2021040975-A1 (WO)
Title: Aqueous dispersion of acrylate-siloxane copolymer particles
Inventor: BUSS HILDA G
IPC: C07F7/08
Filed: 2020-08-05
Abstract: The present invention relates to a composition comprising an aqueous dispersion of acrylate-siloxane copolymer particles comprising structural units of an acrylate monomer; an acid monomer; and a siloxane acrylate monomer of formula I: where R, R 1 , R 2 , Y and x are as defined herein. The composition has a high solids content, a low concentration of siloxane acrylate monomer and low coagulum levels. The composition is useful for forming coatings with improved hydrophobicity, stain resistance, and aesthetic/haptic properties compared with conventional all-acrylic compositions.
Patent WO-2021034893-A1 (WO)
Title: Smart connection management
Inventor: ELLIOT MICHAEL
IPC: H04W72/12
Filed: 2020-08-19
Abstract: A method is provided for managing a number of active wireless data streams in a device. An operating band of the device is detected, wherein the device is capable of simultaneously supporting Wi-Fi and Bluetooth communications by time sharing the operating band between the Wi-Fi and Bluetooth communications. A request is detected for simultaneously operating in at least two of a Wi-Fi communication mode, a Bluetooth source communication mode, or a Bluetooth sink communication mode. In response to detecting the request, only two of the Wi-Fi communication mode, the Bluetooth source communication mode, or the Bluetooth sink communication mode are selected.
Patent WO-2021046225-A1 (WO)
Title: Methods and compositions for treating cancer
Inventor: MATA-FINK JORDI
IPC: C07K14/435
Filed: 2020-09-03
Abstract: The present invention provides methods for treating cancer using GRK2 inhibitors such as small molecule inhibitors of GRK2 among others. The invention also features compositions containing GRK2 inhibitors, methods of diagnosing patients with GRK2-associated cancer and methods of predicting the response of cancer in a subject to treatment with GRK2 inhibitors.
Patent WO-2021055632-A1 (WO)
Title: Interactive system for guiding electronics design and assembly
Inventor: OSBURN EDWARD PAUL
IPC: G06F30/31
Filed: 2020-09-17
Abstract: A computer implemented method is disclosed relating to the design of electronic circuits and systems. In some examples, a graphical user interface is utilized to receive first information relating to a requested electronic circuit. The first information includes a selected type of electronic circuit and one or more operating criteria relating to requested fundamental functionality of the selected type of electronic circuit. Second information is also received, relating to requested secondary attributes of a hypothetical candidate electronic circuit that satisfies the first information. In response, a set of candidate circuit architectures are displayed satisfying the first information, as well as a visualization of how each of the candidate circuit architectures relates to the second information.
Patent WO-2021076290-A1 (WO)
Inventor: KISTNER RALF
IPC: G06F15/16
Filed: 2020-09-24
Abstract: A bi-directional data synchronization system and method is provided to facilitate data communication and synchronization between a remote client device and an application server. In one embodiment, a method in a client device executing a mobile application where the client device is in communication with the application server over a network connection having unreliable network connectivity includes storing in a first table at the client device data associated with at least one data bucket designated to the client device, the data associated with the data bucket being a subset of data associated with the mobile application; in response to the network connection not being established, storing in a second table at the client device changes to the data in the first table as a result of the executing; and in response to the network connection being established, performing synchronization of data with the application server.
Patent WO-2021061881-A1 (WO)
Inventor: CHEN YUCHUNG K
IPC: A43B13/12
Filed: 2020-09-24
Abstract: A sole structure for an article of footwear includes a midsole having a medial edge and a lateral edge. The sole structure also include a first lower rib extending from the medial edge to the lateral edge of the midsole. The first lower rib includes a portion spaced from the midsole between the medial edge and the lateral edge. The sole structure further includes a medial flex member disposed between the midsole and the first lower rib near the medial edge and a lateral flex member disposed between the midsole and the first lower rib near the lateral edge. The medial flex member and the lateral flex member are configured to flex the first lower rib relative to the midsole in response to a force of a predetermined magnitude.
Patent WO-2021067597-A1 (WO)
Inventor: KHURANA RISHABH
IPC: A61B34/32
Filed: 2020-10-01
Abstract: A surgical system comprising a tool for engaging a target site, a manipulator configured to support the tool, and a sensing system configured to detect one or more system conditions associated with one or more of the tool, the manipulator, the target site, or combinations thereof. A controller is coupled to the manipulator and to the sensing system is configured to operate the manipulator between: a first mode to maintain alignment of the tool with respect to the target site according to a first constraint criteria, and a second mode to maintain alignment of the tool with respect to the target site according to a second constraint criteria different from the first constraint criteria. The controller changes operation of the manipulator from the first mode to the second mode in response to determining that at least one of the one or more system conditions satisfies a predetermined condition.
Patent WO-2021067892-A1 (WO)
Inventor: SARKIS GABI
IPC: H04L5/00
Filed: 2020-10-03
Abstract: Certain aspects of the present disclosure provide techniques for channel estimation for two-stage sidelink control using sidelink data channel demodulation reference signals (DMRS). A user equipment (UE) can transmit DMRS for the sidelink data channel. The UE may transmit the second stage of the sidelink control using antenna ports or a precoder used for the sidelink data channel. The receiving device may receive the DMRS, estimate the channel, and demodulate the second stage of the sidelink control based on the estimated channel. The receiving device may flexibly determine the DMRS to use for the estimation and demodulation.
Patent WO-2021087282-A1 (WO)
Inventor: CLARK SEAN
IPC: C12N9/12
Filed: 2020-10-30
Abstract: Compositions for CDKL5 gene therapy are provided, as well as recombinant CDKL5 proteins. Such CDKL5 gene therapy compositions and/or recombinant CDKL5 proteins may incorporate cell-penetrating polypeptides and/or leader signal polypeptides. Also provided are methods of producing such gene therapy compositions and recombinant CDKL5 proteins, as well as pharmaceutical compositions, methods of treatment, and uses of the gene therapy compositions and recombinant CDKL5 proteins.
Patent WO-2022098346-A1 (WO)
Inventor: GÜCKEL HARTMUT
IPC: B61L29/22
Filed: 2020-11-04
Abstract: Un système de commande de passage à niveau (400, 600) comprend un circuit de voie ayant un système de prédiction de passage à niveau (GCP) (40), et au moins un dispositif de manœuvre auxiliaire (420, 430) relié aux rails (20a, 20b) de la voie ferrée (20), un véhicule ferroviaire circulant sur la voie ferrée (20) provoquant un changement d'impédance lors de l'entrée dans le circuit de voie, le ou les dispositifs de manœuvre auxiliaires (420, 430) détectant la présence du véhicule ferroviaire circulant sur la voie ferrée (20) et générant un changement auxiliaire de l'impédance du circuit de voie, et le système GCP (40) générant des signaux d'activation de passage à niveau en réponse au changement de l'impédance ou au changement auxiliaire de l'impédance du circuit de voie. Le dispositif de manœuvre auxiliaire est utilisé pour améliorer la fiabilité en cas de manœuvre médiocre. Selon un premier mode de réalisation, le dispositif de manœuvre auxiliaire est une dérivation supplémentaire (428) entre des rails et dans la distance d'approche (AL), la dérivation étant activée par un détecteur de véhicule distinct (422). Selon un second mode de réalisation, la dérivation d'extrémité (SI) est désactivée par un détecteur de véhicule (422) avant la distance d'approche (AL).
Patent WO-2021092279-A1 (WO)
Inventor: HU JIAN
IPC: A61K31/56
Filed: 2020-11-06
Abstract: Provided herein are methods of treating a dysmyelinating/demyelinating disease or condition in a patient in need thereof. The methods comprise restoring Qki-PPARβ-RXRα- dependent lipid metabolism in myelin. For example, the methods comprise administering a PPARβ agonist or an RXR agonist to the patient.
Patent WO-2021096921-A1 (WO)
Title: Low contaminant antimicrobial vaccines
Inventor: WYAND MICHAEL
IPC: A61P37/02
Filed: 2020-11-11
Abstract: Disclosed are antimicrobial vaccines comprising oligosaccharide β-(1→6)-glucosamine groups.
Patent WO-2021097107-A1 (WO)
Title: Crystalline forms of a magl inhibitor
Inventor: GRICE CHERYL A
IPC: C07D213/55
Filed: 2020-11-12
Abstract: Described herein is new crystalline forms of the MAGL inhibitor 2-(2-((4-(((1,1,1,3,3,3-hexafluoropropan-2-yl)oxy)carbonyl)piperazin-1-yl)methyl)-5-(trifluoromethyl)phenoxy)-2-methylpropanoic acid, or a pharmaceutically acceptable salt thereof.
Patent WO-2022115106-A1 (WO)
Inventor: VOISHVILLO ALEXANDER
IPC: H04R1/34
Filed: 2020-11-26
Abstract: Un dispositif d'entraînement à la compression pour un haut-parleur omnidirectionnel comprend un ensemble moteur et une membrane annulaire disposée coaxialement sous l'ensemble moteur et connectée de manière opérationnelle à celui-ci. Un bouchon de mise en phase est monté sur l'ensemble moteur et comprend une partie supérieure faisant face à la membrane, une partie inférieure s'étendant vers le bas depuis la partie supérieure d'une première extrémité à une seconde extrémité, et une pluralité d'ouvertures qui s'étendent à travers celle-ci. La partie inférieure a une surface intérieure qui définit une cavité et s'élargit de la première extrémité à la seconde extrémité, la surface intérieure ayant une pluralité de canaux radiaux avec une orientation diagonale connectés acoustiquement aux ouvertures. Un boîtier est monté sur le bouchon de mise en phase et reçu dans la cavité, le boîtier ayant une surface extérieure espacée de la surface intérieure de la partie inférieure pour former un guide d'ondes disposé pour rayonner des ondes sonores vers le bas et vers l'extérieur avec une directivité verticale asymétrique.
Patent WO-2022125108-A1 (WO)
Inventor: CAGNONE MASSIMO
IPC: D21H27/40
Filed: 2020-12-11
Abstract: Les produits en papier divulgués présentent un motif de gaufrage qui est esthétiquement agréable et fournit des propriétés de produit améliorées, telles qu'un bon volume, tout en réduisant les problèmes de traitement, tels que le plissage. Les motifs de gaufrage comprennent généralement un motif d'arrière-plan et de premier plan, le motif d'arrière-plan étant le motif dominant et permettant au produit d'avoir un aspect uniforme qui connote la féminité, la douceur et la purification. Le motif d'arrière-plan est formé de préférence entièrement à partir d'éléments de dessin ouverts tels que des premier, deuxième et troisième éléments de ligne curviligne ouverts, les deuxième et troisième éléments de ligne étant distincts, des éléments de ligne curviligne de forme similaire étant disposés parallèlement les uns aux autres et espacés d'environ 1,0 mm ou moins.
Patent WO-2020232463-A1 (WO)
Inventor: CHAEICHIAN SINA
IPC: B32B27/38
Filed: 2020-05-04
Abstract: This disclosure is directed to methods directly adhering epoxy-based, and other thermosetting surfacing films to solid thermoplastic surfaces and the structures derived or derivable from these methods. In some embodiments, the disclosure is also directed to composite structures comprising a thermoplastic substrate directly bonded to a thermoset(ting) surfacing film; wherein the direct bonding defines an interface between a thermoplastic surface of the thermoplastic substrate and a first surface of the thermoset(ting) surfacing film.
Patent WO-2021142342-A1 (WO)
Title: Compositions and methods for the targeting of pcsk9
Inventor: OAKES BENJAMIN
IPC: C12N15/113
Filed: 2021-01-08
Abstract: Provided herein are systems comprising Class2, Type V CRISPR polypeptides, guide nucleic acids (gNA), and optionally donor template nucleic acids useful in the modification of a PCSK9 gene. The systems are also useful for introduction into cells, for example eukaryotic cells having mutations in the PCSK9 gene. Also provided are methods of using such CasX:gNA systems to modify cells having such mutations.
Patent WO-2021146394-A1 (WO)
Title: Optimized bacteria engineered to treat disorders involving the catabolism of leucine, isoleucine, and/or valine
Inventor: JAMES MICHAEL
IPC: C12N15/70
Filed: 2021-01-14
Abstract: The present disclosure provides recombinant bacterial cells that have been engineered with genetic circuitry which allow the recombinant bacterial cells to sense a patient' s internal environment and respond by turning an engineered metabolic pathway on or off. When turned on, the recombinant bacterial cells complete all of the steps in a metabolic pathway to achieve a therapeutic effect in a host subject. These recombinant bacterial cells are designed to drive therapeutic effects throughout the body of a host from a point of origin of the microbiome. Specifically, the present disclosure provides recombinant bacterial cells comprising a heterologous gene encoding an improved leucine catabolism enzyme with higher activity and/or specificity for leucine over other branched chain amino acids, such as isoleucine or valine. The disclosure further provides pharmaceutical compositions comprising the recombinant bacteria, and methods for treating disorders involving the catabolism of leucine, isoleucine, and/or valine using the pharmaceutical compositions disclosed herein.
Patent WO-2021154644-A1 (WO)
Title: Systems and methods for generating subsurface feature prediction probability distributions as a function of position in a subsurface volume of interest
Inventor: PROCHNOW SHANE J
IPC: G06T1/00
Filed: 2021-01-25
Abstract: Systems and methods are disclosed for generating subsurface feature prediction probability distributions from a subsurface feature as a function of position in a subsurface volume of interest. A computer- implemented method includes: obtaining subsurface data and well data (202), generating subsurface feature values (204), generating subsurface feature realizations (206), generating subsurface feature realization uncertainty values (208), generating subsurface parameter values (210), generating subsurface parameter realizations (212), generating subsurface feature prediction probability distributions (216), generating a first representation of likelihoods of the subsurface feature values (218), and displaying the first representation (220).
Patent WO-2021221744-A1 (WO)
Inventor: KUNKEE ELIZABETH T
IPC: H01P11/00
Filed: 2021-01-27
Abstract: An exemplary semiconductor technology implemented microwave filter includes a dielectric substrate with metal traces on one surface that function as frequency selective circuits and reference ground. Other metal traces on the other surface of the substrate also provide reference ground. Bottom and top enclosures that enclose the substrate have respective interior recesses with deposited continuous metal coatings. A plurality of metal bonding bumps or bonding wall extends outwardly from the projecting walls of the bottom and top enclosures. The bonding bumps on the bottom and top enclosures engage reference ground metal traces on respective surfaces of the substrate. As a result of applied pressure, the bonding bumps and respective reference ground metal traces together with the through-substrate vias form a metal-to-metal singly-connected ground reference structure for the entire circuitry.
Patent WO-2022060404-A1 (WO)
Title: Radiographic dental jigs
Inventor: BELL PATRICK
IPC: A61C19/04
Filed: 2021-02-05
Abstract: Example radiographic dental jigs include a generally vertical post traversed by a generally horizontal beam to create a cross that can be used for marking a dental patient's midline (vertical line centered between the eyes), incisal edge plane, and forward lip position. The jig is radiographically scanned along with multiple fiducial markers on the patient's jaw to generate a first scan result. In some examples, physical models of the patient's jaws are also scanned to generate upper and lower jaw images. The upper and lower jaw images are shifted to coincide with the first scan result. Portions of the first scan result, including an image of the dental jig, are superimposed onto the properly shifted upper and lower jaw images to create a composite image. The composite image shows the dental jig in proper relation to the patient's upper and lower jaws, thereby rendering a conventional stick bite virtually obsolete.
Patent WO-2021162988-A1 (WO)
Title: Method and apparatus for delivering temperature controlled water
Inventor: SALEEM FAWAZ
IPC: G05D23/13
Filed: 2021-02-08
Abstract: A method and apparatus for delivering water to a user at a control temperature by receiving cold water, receiving hot water and then adjusting a hot-side graduated- valve and a cold-side graduated-valve in order to adjust the temperature of mixed water according to an initial target temperature value. The temperature of the mixed water is sensed in order to provide feedback, which is necessary to adjust the hot-side graduated valve and the cold-side graduated valve. In some embodiments, hot-side graduated valve and the cold-site graduate-valve are also adjusted to achieve a target flow rate. A target temperature and a target flow rate is communicated to the apparatus by way of an air-gesture sensor.