baber/WOPTO huggingface dataset:
Patent SI-3183247-T1 (SI)
Title: Aminopyrimidinyl compounds as jak inhibitors
Inventor: FENSOME ANDREW
IPC: C07D519/00
Filed: 2015-08-07
Abstract: A compound having the structure: or a pharmaceutically acceptable salt thereof, wherein X is N or CR, where R is hydrogen, deuterium, C1-C4 alkyl, C1-C4 alkoxy, C3-C6 cycloalkyl, aryl, heteroaryl, aryl(C1-C6 alkyl), CN, amino, alkylamino, dialkylamino, CF3, or hydroxyl; A is selected from the group consisting of a bond, C═O, —SO2—, —(C═O)NR0—, and —(CRaRb)q—, where R0 is H or C1-C4 alkyl, and Ra and Rb are independently hydrogen, deuterium, C1-C6 alkyl, C3-C6 cycloalkyl, aryl, aryl(C1-C6 alkyl), heteroaryl, (C1-C6 alkyl)heteroaryl, etc.; A′ is selected from the group consisting of a bond, C═O, —SO2—, —(C═O)NR0′, —NR0′(C═O)—, and —(CRa′Rb′)q—, where R0′ is H or C1-C4 alkyl, and Ra′ and Rb′ are independently hydrogen, deuterium, C1-C6 alkyl, C3-C6 cycloalkyl, aryl, aryl(C1-C6 alkyl), heteroaryl, (C1-C6 alkyl)heteroaryl, heteroaryl(C1-C6 alkyl), and heterocyclic(C1-C6 alkyl); Z is —(CH2)h— or a bond, where one or more methylene units are optionally substituted by one or more C1-C3 alkyl, CN, OH, methoxy, or halo, and where said alkyl may be substituted by one or more fluorine atoms; R1 and R1′ are independently selected from the group consisting of hydrogen, deuterium, C1-C4 alkyl, C3-C6 cycloalkyl, aryl, heteroaryl, aryl(C1-C6 alkyl), CN, etc., wherein said alkyl, aryl, cycloalkyl, heterocyclic, or heteroaryl is further optionally substituted with one or more substituents selected from the group consisting of C1-C6 alkyl, halo, CN, C1-C4 alkylamino, C3-C6 cycloalkyl, etc.; R2 is selected from the group consisting of hydrogen, deuterium, C1-C6 alkyl, C3-C6 cycloalkyl, halo, and cyano, where said alkyl may be substituted by one or more fluorine atoms; R3 is selected from the group consisting of hydrogen, deuterium, and amino; R4 is monocyclic or bicyclic aryl or monocyclic or bicyclic heteroaryl wherein said aryl or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of C1-C6 alkyl, heterocycloalkyl, halo, C3-C6 cycloalkyl, etc., where said alkyl, cycloalkyl, alkoxy, or heterocycloalkyl may be substituted by one or more C1-C6 alkyl, halo, CN, OH, alkoxy, amino, —CO2H, —(CO)NH2, —(CO)NH(C1-C6 alkyl), or —(CO)N(C1-C6 alkyl)2, and where said alkyl may be further substituted by one or more fluorine atoms; R5 is independently selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C6 alkoxy, and hydroxyl; h is 1, 2 or 3; j and k are independently 0, 1, 2, or 3; m and n are independently 0, 1 or 2; and, q is 0, 1 or 2. Also provided are methods of treatment as Janus Kinase inhibitors and pharmaceutical compositions containing the compounds of the invention and combinations with other therapeutic agents.
Patent TR-201002817-T1 (TR)
Title: İki tekerlekli hibrid bir araç için transmisyon sistemi
Inventor: SAMRAJ JABEZ DHINAGAR
IPC: B60K6/00
Filed: 2008-10-13
Abstract: Burada açıklanan mevcut bulus, iki tekerlekli hibrid bir araç (100) için olan  transmisyon sistemi (108) ile ilgilidir . Transmisyon sistemi (108), bir çift çekiş elemanından (202, 302, 206, 304) ve tahrik edilmis bir elemandan (212, 306) olusmaktadır . Çekis elemanlarından (202, 302) bir tanesi iki tekerlekli hibrid araç  (100) üzerinde içten patlamalı bir motora bağlanmıs durumdayken diğer çekis  elemanı (206, 304) iki tekerlekli hibrid araç (100) üzerinde bir adet elektrik  motoruna (210) bağlanmıs durumdadır . Diğer yandan, tahrik edilmis eleman (212, 306), iki tekerlekli hibrid araçta (100) bir disli kutusu (220) üzerinden çekis  tekerleğine (106) bağlıdır . Bilinen transmisyon elemanı (214, 308), çekis  elemanlarından (202, 302, 206, 304) gelen gücü tahrik edilmis elemana (212, 306) transfer edilmesine kolaylık sağlamaktadır .
Patent DE-3588104-T2 (DE)
Inventor: SIMPSON JOHN B
IPC: A61F2/958
Filed: 1985-05-24
Granted: 1996-09-19
Abstract: The antherectomy apparatus has a cylindrical housing (12) of rigid material having a rounded distal end. The housing is formed with a cut-out extending longitudinally on one side. A cutter within the housing is movable longitudinally of the cut-out. A flexible tube (36) is secured to the housing and contains a cable (41) connected to the cutter. A drive is connected to the cable for rotating the cutter (31) while the latter moves longitudinally of the housing.
Patent DE-3650390-T2 (DE)
Inventor: JENKINS ANTHONY WILLIAM
IPC: A61K9/26
Filed: 1986-05-28
Granted: 1996-04-04
Abstract: A sustained release, oral pharmaceutical composition in solid unit dosage form, for application to the mucosa of the oral or nasal cavity, comprises compressed, mucosa adhesive cellulose, coated granules, the granules comprising a drug, a higher aliphatic alcohol and a hydrated water soluble hydroxyalkyl cellulose. 
<??>Preferably the composition is in the form of a buccal tablet, especially a kidney shaped buccal tablet. Preferred materials are morphine as the drug, hydroxypropyl cellulose as the mucosa adhesive cellulose, cetostearyl alcohol as the aliphatic alcohol and hydroxyethyl cellulose as the water soluble cellulose. 
<??>The composition has enhanced adherent properties (to the mucosa) and prolongs the bioavailability of the drug.
Patent DE-3687946-T2 (DE)
Inventor: NOGAMI IKUO
IPC: C12P7/60
Filed: 1986-10-17
Granted: 1993-06-17
Abstract: 2-keto-L-gulonic acid is produced in a high yield by contacting a microorganism of the genus Pseudogluconobacter, either as it is or after processing, with L-sorbose.
Patent DE-3850842-T2 (DE)
Inventor: MIYAZAWA KAZUTOSHI
IPC: C09K19/34
Filed: 1988-10-17
Granted: 1995-01-19
Abstract: Optically active 2,5-diphenyl pyrimide compounds, for use in liquid crystal composition have the formula: <CHEM> in which R<1> is a C1-C20 alkoxy group; R<2> is an alkyl, acyl or alkoxyacyl group containing up to 20 carbon atoms; <CHEM> and * indicates an asymmetric carbon atom. s
Patent DE-3851700-T2 (DE)
Inventor: HERPICHBOEHM BERND G HERPICHBO
IPC: B29C45/73
Filed: 1988-07-27
Granted: 1995-05-18
Abstract: An apparatus is provided for making color comparisons between a test sample and a plurality of color samples (24). The color samples (24) are arranged on a circle on a rotatable member (2) and are successively moved into position adjacent a test sample. When an operator determines that a color sample (24) adjacent the test sample is closest in color to the test sample he operates a switch (53) which causes a stored numerical value associated with that sample to be read out and displayed on a display device (51).
Patent DE-3852495-T2 (DE)
Inventor: BENEDEK GEORGE
IPC: A61B3/117
Filed: 1988-08-31
Granted: 1995-04-20
Abstract: A method is disclosed for using quasielastic light scattering to determine the degree of cataractogenesis of a lens in vivo. By collecting and analyzing light (18) scattered from the lens, it is possible, using the autocorrelation function or the power spectrum (160), to separate the fluctuations into two components: one caused by fast diffusing proteins and one caused by slow diffusing protein aggregates. This data may be applied to an experimentally determined and theoretically deduced universal curve in order to determine quantitatively (170) the degree of cataractogenesis at that particular location in the lens.
Patent DE-3853382-T2 (DE)
Inventor: CANLAS PRUDENCIO S
IPC: B25C1/00
Filed: 1988-05-24
Granted: 1995-08-10
Abstract: A portable power operated fastener driving device (10) including a work contact assembly (40) having a manual adjusting mechanism (42) for adjusting the extent to which fasteners driven by the fastener driving element (26) of the device are countersunk into the workpiece. The manual adjusting mechanism includes a manually operable member (78) movable by manual engagement to effect an adjustment of the adjusting mechanism and a releasable lock (82) movable between a locking position for locking the manually operable member against manual movement and a releasing position enabling the manually operable member to be manually moved. A guard assembly (104) encloses at least a portion of the adjusting mechanism including the manually operable member. The guard assembly includes a manually operable access door (84) movable between a closed position wherein the manually operable member is manually inaccessible within the guard assembly and an open position wherein the manually operable member is manually accessible. A mechanism (130) is provided for moving the releasable lock between its locking and releasing positions when the access door is manually moved between its closed and open positions respectively.
Patent DE-3856456-T2 (DE)
Inventor: VAN DEN BERG KAREL
IPC: A01J7/00
Filed: 1988-07-21
Granted: 2002-05-16
Abstract: In a method of automatically milking animals, e.g. cows, in a milking parlour, teat cups (80) carried by a robot arm (7) of a milking robot can be moved individually upwardly relative to the robot arm (7), whereby a vacuum is produced in the teat cup (80) moved upwardly, so that the teat cup (80) can suck to a relevant teat. Thereafter the teat cup (80) is released from the robot arm (7) but remains connected therewith via a flexible connecting member (81), by means of which the teat cup (80) is pulled towards and against the robot arm (7) when the milking flow through the teat cup (80) has ended. The specification further describes an implement for performing this method.
Patent DE-3872199-T2 (DE)
Inventor: GOTTWALD EBERHARD FRITZ
IPC: A61K9/16
Filed: 1988-12-16
Granted: 1992-12-17
Abstract: The present invention provides a pharmaceutical granule composition comprising cimetidine and, as a granulating agent and taste-masking agent, an ester of a polyhydroxy compound, and where desired a palatable pharmaceutically acceptable emulsifier. Particular esters are glycerol esters. The granules of the present invention can be used in the preparation of chewable tablets which have good palatability and bioavailability.
Patent TR-199903324-T2 (TR)
Inventor: CHANG KWEN-JEN
IPC: A61K38/08
Filed: 1997-10-01
Abstract: Bir hayvana karisik delta/mu opioid agonisti veya bir nefes darligina yol açan ilaç uygulandiktan sonra ortaya çikan ilaç kökenli nefes darligi, kas sertligi veya bulanti/kusmayi azaltmak, tedavi etmek veya önlemek için bir yöntem olup, bahsedilen ilaci alan hayvana, bir delta reseptör agonist bilesiginin etkili bir miktarinin uygulanmasindan olusur. Sekil, mu agonisti alfenta tarafindan uyarilan analjezi ve nefes darligi üzerinde delta agonist BW373U86 nin arti izomerinin etkisini gösterir. Delta agonist bilesigi formül (I) bilesiginden olusabilir, ki burada Ar, G, Z, R2, R3, R4, R5, R6, ve R7 degiskenlerinin her biri buradaki tarifnamede tarif edildigi gibidir.
Patent DE-60003509-T2 (DE)
Inventor: BAYOD JASANADA MIGUEL SANTOS
IPC: C07H17/08
Filed: 2000-02-23
Granted: 2004-04-15
Abstract: The present invention describes a new procedure for the preparation of the macrolide azithromycin in its crystalline dihydrate form, which is characterized and clearly differentiated by means of the following methods and techniques:     1. IR Spectroscopy.   2. Differential Scan Calorimetry (DSC).   3. X-Ray Diffraction.   <IMAGE>
Patent DE-60004959-T2 (DE)
Inventor: LEFEBVRE RENE
IPC: A23G9/28
Filed: 2000-01-18
Granted: 2004-03-11
Abstract: Confectionery bar manufacturing procedure consists of covering a core (3) e.g. for wafer or biscuit with a layer of a cooked sugar product (8) such as caramel, marshmallow or nougat topped with nuts, cereal or dried fruit (90) before coating with chocolate. The procedure consists of covering a core (3) e.g. for wafer or biscuit with a layer of a cooked sugar product (8) such as caramel, marshmallow or nougat topped with nuts, cereal or dried fruit (90) before coating with chocolate. As the core passes along a conveyor (20) the cooked sugar layer is applies to it from a cooling roller (4) so that it moulds to the shape of the top and sides of the core. The topping (90) is applied to the cooked sugar layer on the roller, and the bars are cut to length at the outlet end of the conveyor before coating with chocolate.
Patent DE-60005414-T2 (DE)
Inventor: PARISOTTO DAVIDE
IPC: A43B5/04
Filed: 2000-01-13
Granted: 2004-06-24
Abstract: Ski boot (1) comprising a sole (2) and a shell (3)of plastic material designed to house the wearer's foot and including a flexible portion (10) in correspondence with the metatarsus area, a leg piece (4) hinged to the shell substantially at the ankle and designed to wrap the lower part of the leg of the wearer at the back and at the sides, a front closure tongue (8), fastening devices (2,3) and releasable securing means between the tongue (8) and the shell (3); the tongue (8) comprises a lateral portion (13) which extends on an internal lateral wall (6) of the shell (3), and the lateral portion (13) projects on the internal side of the shell (10) beyond the profile of the flexible portion. <IMAGE>
Patent DE-60015572-T2 (DE)
Inventor: SOLIMAN S
IPC: G01S1/00
Filed: 2000-08-30
Granted: 2005-11-10
Abstract: A method and apparatus for conducting a pilot signal search in a wireless communications network. The location of a mobile is determined within the network. This location is then used in determining search window sizes and other search parameter information that is used to search all pilot signals identified in a designated pilot signal set. Search window size is also determined based upon the location of the mobile and another component related to multipath effects for a transmitted pilot signal. <IMAGE>
Patent DE-60031686-T2 (DE)
Inventor: HAN YONGXIN
IPC: C07D413/12
Filed: 2000-07-17
Granted: 2007-08-30
Abstract: Compounds represented by formula I:as well as pharmaceutically acceptable salts, esters, N-oxides and hydrates thereof are disclosed. Pharmaceutical compositions and methods of use are also included. The compounds are active against the caspase-3 enzyme, and thus are useful to treat caspase-3 mediated diseases and conditions.
Patent DE-60032142-T2 (DE)
Inventor: DEL VECCHIO ARTHUR
IPC: C02F1/44
Filed: 2000-06-02
Granted: 2007-03-29
Abstract: A system is provided for withdrawing permeate from a substrate through a filter and for cleaning the filter in situ. The system includes a vessel configured to contain a substrate and a compartment connected to receive substrate from the vessel and connected to return a portion of received substrate to the vessel during normal operation of the system. The system also includes a filter positioned at least partially within the compartment to withdraw permeate from substrate in the compartment during normal operation of the system. A source of cleaning solution is connected to the compartment to deliver cleaning solution into the compartment and into contact with the filter during cleaning operation of the system. The compartment facilitates circulation of substrate in the vessel during normal operation of the system and substantially prevents introduction of cleaning solution from the compartment into contact with substrate contained in the vessel during cleaning operation. A method is also provided.
Patent DE-60033621-T2 (DE)
Inventor: FUSSELMAN DAVID F
IPC: H01R13/504
Filed: 2000-11-17
Granted: 2007-11-29
Abstract: The invention relates to an electrical connector (10) comprising an electrical contact (22); and a housing (20). The housing (20) comprises a first member (24) and a second member (26). The first member (24) comprises a contact receiving channel (40, 42). The second member (26) is over-molded onto the first member (24). The electrical contact (22) is located in the channel (40, 42) and retained on the housing (20) by a capture of the contact between the first (24) and second (26) members. The first member (24) and the contact (22) extend past a first end of the capture of the contact between the first (24) and second (26) members.
Patent DE-60101964-T2 (DE)
Inventor: WINKLER UWE F
IPC: C07F17/00
Filed: 2001-06-01
Granted: 2005-01-05
Abstract: Chiral metallocenes are prepared by reacting a salt of an asymmetric bis(cyclopentadienyl)-moiety-containing ligand with a tertiary heteroaromiatic amine adduct of a transition, lanthanide, or actinide metal halide in an organic solvent or diluent so as to produce said chiral metallocene.
Patent DE-60110221-T2 (DE)
Inventor: BERTHELOT JEAN-LUC
IPC: G07C9/00
Filed: 2001-05-23
Granted: 2006-03-09
Abstract: The invention concerns a method for generating a digital signature related to an electronically written document, so that it fulfils the legal requirements with respect to electronic data, in like manner as a written signature on paper, and that it constitutes evidence of the deliberate will of the engagement. The inventive method consists in, simultaneously with the identification of the signatory by a device provided therefor, generating spherical co-ordinates to form points (A, B, C and P) whereof the dimensional value is derived from the conversion of identification data, of the identity and the set of characters and codes of services constituting the electronically written document. A certifying third party identifies and authenticates the document related to the signature while preserving confidentiality of its contents and its irreversibility, it archives the data of the original geometric figure capable of physical represented in three dimensions, for example in the form of a sphere (S) and a polyhedron. The invention is applicable to any executed document, requiring authenticity, through modern communication means.
Patent DE-60113398-T2 (DE)
Inventor: MIGLIERINI GIULIANA
IPC: A61P19/02
Filed: 2001-03-16
Granted: 2006-06-29
Abstract: The present invention is related to polysaccharide esters of N-derivatives of glutamic acid (N-GA derivatives). These polysaccharidic esters have antiproliferative activity and are characterized by a low systemic toxicity. The esters of the invention are used in the prevention and therapy of diseases caused by cellular hyperproliferation, particularly psoriasis, tumors, rheumatoid arthritis, or intestinal inflammatory pathologies.
Patent DE-60115067-T2 (DE)
Inventor: BENNETT S
IPC: G03F7/26
Filed: 2001-09-13
Granted: 2006-07-13
Abstract: A printing plate for computer-to plate lithography having a laser-ablatable member supported by a substrate. At least one portion of the laser-ablatable member is formed form an acrylic polymer containing laser-sensitive particles. The laser-sensitive particles absorb imaging radiation and cause the portion of the laser-ablatable member containing the laser sensitive particles and any overlying layers to be ablated. Alternatively, the printing plate may include a printing member with an initial affinity for a printing fluid that changes to another affinity to printing fluid upon treatment with radiation.
Patent DE-60115274-T2 (DE)
Inventor: HOFFMANN JENS
IPC: C07J7/00
Filed: 2001-10-17
Granted: 2006-07-27
Abstract: The present invention relates to methods and uses for preventing or treating hormone-dependent disease, in particular breast cancer, in a mammal by antiprogestins, in particular antiprogestin 11beta-(4-acetylphenyl)-17beta-hydroxy-17alpha-(1,1,2,2,2-pentafluoroethyl)-estra-4,9-dien-3-one or a pharmaceutically acceptable derivative or analogue thereof. The invention further relates to pharmaceutical compositions comprising said antiprogestin.
Patent DE-60119336-T2 (DE)
Inventor: SU MINGJAI
IPC: A61P9/06
Filed: 2001-02-28
Granted: 2007-05-10
Abstract: The present invention discloses thaliporphine and its derivatives for the treatment and/or prophylaxis of cardiac diseases, including cardiac arrhytmia, myocardial ischemia or myocardial infraction, and sudden death caused by cardiac arrhythmia or acute myocardial infarction.
Patent DE-60120104-T2 (DE)
Inventor: SELVE NORMA DR
IPC: A61P29/00
Filed: 2001-03-20
Granted: 2006-09-21
Abstract: The present invention concerns the use of compounds of the Formula (I): <CHEM> for treating different types and symptoms of acute and chronic pain, especially non neuropathic inflammatory pain in mammals. The pain to be treated may be e.g. chronic inflammatory pain, rheumatoid arthritis pain and/or secondary inflammatory osteoarthritic pain. The compounds show an antinociceptive profile and differ from classical analgesics like opioids and non-steroidal anti-inflammatory drugs (NSAIDS) and are useful as specific analgesics.
Patent DE-60123464-T2 (DE)
Inventor: BLASI ESCUDE ALFRED
IPC: A61K33/06
Filed: 2001-02-22
Granted: 2007-08-02
Abstract: The composition comprises a source of sodium, a source of potassium, a source of calcium and a source of magnesium, which consist of physiologically acceptable compounds of sodium, potassium, calcium and magnesium, soluble or dispersible in an aqueous medium, which in solution or dispersion in said aqueous medium provide ions of said elements. The composition is useful for the treatment of diseases of muscular, neuromuscular or osseous etiology, as well as in the treatment of states lacking or deficient in said elements, and in the muscular recovery of healthy persons and animals.
Patent DE-60125746-T2 (DE)
Inventor: DONNELLY WEGNER
IPC: B60L50/13
Filed: 2001-04-25
Granted: 2007-11-08
Abstract: Prior battery-powered electric locomotives have used multiple diesel engines to charge the batteries and have not been commercially accepted. The present invention provides a yard switcher which combines battery storage with a gas microturbine generator to provide an effective fuel-efficient and environmentally friendly locomotive.
Patent DE-60133555-T2 (DE)
Inventor: WEIDNER JOHN J
IPC: A61K47/04
Filed: 2001-06-29
Granted: 2008-09-18
Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provide as well.
Patent DE-60206047-T2 (DE)
Inventor: MADDOCKS JOHN LEYSHON
IPC: A61M5/315
Filed: 2002-06-18
Granted: 2006-06-29
Abstract: A device (10) is provided for use in controlling the administration of material by administration apparatus. The device is selectively operable between a first condition in which the administration of material from the apparatus (10) is prevented and a second condition which allows material to be dispensed from the apparatus (10). The device also comprises means (13) indicating appropriate administration from the apparatus (12).
Patent DE-60211999-T2 (DE)
Inventor: MAJERCAK DAVID C
IPC: A61M29/02
Filed: 2002-02-28
Granted: 2007-02-01
Abstract: A preferred embodiment of a stent provides a folded strut section that provides both structural rigidity and reduction in foreshortening of the stent mechanism. A flexible section provides flexibility for delivery of the stent mechanism. In a second embodiment, flexible section columns are angled with respect to each other, and to the longitudinal axis of the stent. These relatively flexible sections are oppositely phased in order to negate any torsion along their length. In yet another embodiment, the flexible connector can take on an undulating shape (like an "N"), but such that the longitudinal axis of the connector is not parallel with the longitudinal axis of the stent. Finally, a new method is disclosed for making stents. The method consists of performing a standard photochemical machining process of cutting, cleaning and coating the tube with a photoresist. However, unlike former methods, the photoresist image is developed on the surface of the cylindrical metallic tube, which results in a controlled variable etching rate at selected sites on the cylindrical metallic tube during the etching process. Further embodiments provide living hinge connectors and connections along the length of the radial strut member.