baber/WOPTO huggingface dataset:
Patent EA-012907-B1 (EA)
Title: METHOD OF RACEMIZATION OF THE R(-) ISOMER OF THE (2-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-c]PYRIDINE-5(4H)-ACETIC ACID METHYL ESTER
Inventor: HAJICEK JOSEF
IPC: C07D495/04
Filed: 2006-03-03
Abstract: A method of racemization of the R(-) isomer of the (2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid methyl ester of the formula II (also called R clopidogrel) is performed via conversion of a portion thereof to the S(+) isomer of the formula I and preparing the S(+) isomer of the formula I, in which a mixture of substances I and II is dissolved in an ester of the formula Ra(O)ORb, wherein Ra and Rb independently represent a C1-C5 aliphatic substituent or a C5-C8 aromatic substituent, and a solution of R-camphorsulfonic acid in a solvent of the formula RaOH is added to the solution, from the mixed solution the camphorsulfonic salt of the substance of the formula I is crystallized, which is converted to the substance of formula I in the next step; further a base of formula RRRRNOH, wherein R, R, Rand Rare identical or different substituents selected from C1-C5 alkyls or C5, C6 cycloalkyls or aryls, C7-C9 alkyl-cycloalkyls or alkyl-aryls, in a solution in a substance of the formula RaOH is added to the mother liquors after crystallization, thus resulting in a mixture of substances I and II, suitable for preparation of the substance of the formula I.
Patent EA-011654-B1 (EA)
Title: Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
Inventor: BOOKBINDER LOUIS H
IPC: C07H21/04
Filed: 2006-02-23
Abstract: The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally active polypeptide domains of the soluble, neutral active sHASEGP domains are described that include asparagine-linked sugar moieties required for a functional neutral active hyaluronidase domain. Included are modified amino- terminal leader peptides that enhance secretion of sHASEGP. The invention further comprises sialated and pegylated forms of a recombinant sHASEGP to enhance stability and serum pharmacokinetics over naturally occurring slaughterhouse enzymes. Further described are suitable formulations of a substantially purified recombinant sHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity.
Patent EA-015017-B1 (EA)
Title: Window securing means and methods
Inventor: LINDGREN CLAES
IPC: E05C19/16
Filed: 2006-07-15
Abstract: An assembly for securing an openable aperture closure member (11) in closed position relative to an aperture defined by a main frame (12), the aperture closure member (11) including a mechanically rotational means (24, 44, 54) for securing said closure member (11) to the frame (12), the assembly for securing comprising a push and/or pull actuation assembly (35) for easing the securing and/or releasing process for the aperture closure member, the actuation assembly including a handle bar (36) and at least one connecting member (37) which operably connects the handle bar (36) to the mechanical means (24, 44, 54); wherein the push and/or pull actuation assembly (35) is adapted to be translationally movable by an operator and the connecting member (37) is adapted to convert translational movement of the actuation assembly (35) into rotational forcing movement of the mechanically rotational means (24, 44, 54).
Patent EA-015529-B1 (EA)
Title: 3-(imidazolyl)pyrazolo[3,4-b]pyridines
Inventor: LI LIANFA
IPC: C07D401/00
Filed: 2008-05-21
Abstract: Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are 3-imidazoyl-pyrazolo[3,4-b]pyridine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated disease, and as controls in assays for the identification of competitive CCR1 antagonists.
Patent EA-016275-B1 (EA)
Title: Engine converting rotary gas stream into tractive force
Inventor: POSVENCHUK IVAN ALEXANDROVICH
IPC: F02K99/00
Filed: 2009-11-24
Abstract: The invention relates to power units, in particular, to engines converting rotary gas stream in a tractive force and can be used many branches of national economy. An engine comprises a "plate"-like housing, having upper and lower cylindrical parts provided with truncated conical part arranged between cylindrical parts, a nozzle e.g. Laval noozle with a combustion chamber directed at a tangent to the inner generatrix upper cylindrical part of the housing inner conical part with inner cylindrical part, wherein the inner conical part is provided with mechanisms for changing the position relative to the upper conical part, a sealing system and pressure sensors for measuring pressure disposed on the inner conical part.
Patent EA-022345-B1 (EA)
Title: Arylpyrazinone derivatives insulin secretion stimulators, methods for obtaining them and use thereof for the treatment of diabetes
Inventor: BOTTON GERARD
IPC: C07D405/04
Filed: 2009-03-31
Abstract: The present invention relates to arylpyrazinone derivatives of formula (I)wherein R1, R2, R3 and A are as defined in claim 1, as insulin secretion stimulators. The invention also relates to the preparation and use of these pyrazinone derivatives for the prophylaxis and/or treatment of diabetes and pathologies associated.
Patent EA-020636-B1 (EA)
Title: Device for producing tablets and method for conditioning the conveyor belt of such device
Inventor: SCHROMM HANS-KURT
IPC: B01J2/26
Filed: 2011-01-31
Abstract: The invention relates to a device for producing tablets comprising a perforated outer tube drum which is rotatably arranged above a cooling strip and rotates itself around a stationary inner body in which a flowable product to be pastillated passes onto an upper side of the cooling strip using a perforated outer tube drum in a droplet manner and after the solidification of the product drops, the resulting pastilles are taken from the cooling strip. The device comprises a means for applying a separating agent onto the cooling strip, the means comprises at least one spraying nozzle for two substances for spraying the separating agent onto the upper side of the cooling strip. The spraying nozzle thinely sprayes a liquid separating agent using compressed air, wherein the spraying of the separating agent onto the cooling strip creates a hydrophobic surface and a period of time between the spraying the separating agent onto a definite area of the cooling strip and applying product droplets onto said area is long enough for droplets of the sprayed separating agent to fuse in a uniform layer, but short enough for the separating agent despite the small thickness of its layer not to completely volitize or evaporate in said cooling strip area. The invention further relates to a method for conditioning the conveyor belt in such device.
Patent EA-018947-B1 (EA)
Title: Akt and p70 s6 kinase inhibitors
Inventor: DALLY ROBERT DEAN
IPC: A61K31/52
Filed: 2009-11-03
Abstract: The present invention provides AKT and p70 S6 kinase inhibitors of Formula (I)The present invention also provides pharmaceutical compositions comprising compounds of Formula (I), uses of compounds of Formula (I) and methods of using compounds of Formula (I).
Patent EA-027284-B1 (EA)
Title: Transparent glass substrate and method for producing such a substrate
Inventor: SCHIAVONI MICHELE
IPC: H01L31/042
Filed: 2010-01-22
Abstract: This transparent glass substrate (1) has at least one face (3) which is provided with a texturing formed by a plurality of geometric features (5) in relief relative to a general plane of the face (3), the texturing being adapted in order to ensure a transmission of radiation through the substrate greater than the transmission of radiation through a substrate that is identical but lacks texturing. The face (3) of the substrate is furthermore provided with an antireflection layer having a refractive index between the refractive index of air and the refractive index of the glass. The antireflection layer (7) is an etched out superficial portion of the glass substrate (1) on the side of said face (3), comprising a structure based on silica and voids having a characteristic dimension between 0.5 and 50 nm.
Patent EA-020536-B1 (EA)
Title: High performance drilling fluids with submicron-size particles as the weighting agent
Inventor: ZHANG YING
IPC: C09K8/36
Filed: 2010-03-16
Abstract: Methods and compositions utilizing a drilling fluid comprising sub-micron precipitated barite having a weight average particle diameter below about 1 micron. Methods include a method comprising circulating a drilling fluid in a well bore, wherein the drilling fluid comprises a carrier fluid and a weighting agent that comprises sub-micron precipitated barite having a weight average particle diameter below about 1 micron. In some embodiments, the drilling fluid may comprise an invert emulsion. In some embodiments, the sub-micron precipitated barite has a particle size distribution such that at least 10% of particles in the sub-micron precipitated barite have a diameter below about 0.2 micron, at least 50% of the particles in the of the sub-micron precipitated barite have a diameter below about 0.3 micron and at least 90% of the particles in the sub-micron precipitated barite have a diameter below about 0.5 micron.
Patent EA-021015-B1 (EA)
Title: Indazole and pyrazolopyridine compounds as ccr1 receptor antagonists
Inventor: COOK BRIAN NICHOLAS
IPC: C07D471/04
Filed: 2010-10-19
Abstract: Diclosed are CCR1 receptor antagonists of the formula (I)wherein X is nitrogen or -CR; Aris phenyl substituted by 1-2 groups R; Aris phenyl, thiadozolyl, oxadiazolyl, pyrimidinyl, furanyl, thiazolyl or pyridyl each optionally substituted by 1-2 groups R; cyclic G is cyclopropyl or cyclobutyl; Ris hydrogen; Ris hydrogen or R; Ris halogen, Calkylsulfonyl or cyano; Ris hydroxyl, carboxyl, halogen, -CF, -CN, SOH, Calkyl, C-Ccycloalkyl, C-Calkoxy group, -(CH)-COC-Calkyl, (CH)-NRR, R-S(O)(CH)-, R-S(O)-NR-, R-NR-S(O)(CH)-, NR-C(O)-R, -(CH)-C(O)-NRRor morpholinyl; each R, Rare independently hydrogen, Calkyl, Cacyl, cyano-Calkyl, Calkoxycarbonyl-Calkyl, Calkoxycarbonyl-Ccycloalkyl or -(CH)-C(O)-NRR; each R, Rare independently hydrogen or Calkyl; Ris hydrogen or Calkyl, each optionally substituted with one to two Calkoxy, or oxo group; each n, y is independently 0-3; each m is independently 0-2. Also disclosed are compositions and use of compounds of the formula (I).
Patent EA-020129-B1 (EA)
Title: Solid dosage form having an anorectic effect (variants)
Inventor: CHELYAEVA ANASTASIYA GENNADIEVNA
IPC: A61K9/20
Filed: 2012-10-01
Abstract: The invention relates to the pharmaceutical industry and medicine and can be used in the creation and administration of solid dosage forms for the treatment and/or prophylaxis of obesity. The present invention addresses the problem of creating an effective solid dosage form containing sibutramine hydrochloride monohydrate and having an anorectic effect. The problem of interest is solved by the inclusion of additional mineral substances in the solid dosage form and also by the use of carbon-13 and nitrogen-15 isotopes. The technical results of the invention are a greater therapeutic effect (a reduction in body weight or a decrease in the rate of weight gain) in the treatment and/or prophylaxis of obesity with no decrease in the duration of the effect or increase in the concentration of sibutramine hydrochloride monohydrate, and a more rapid onset of said therapeutic effect.
Patent EA-023276-B1 (EA)
Title: Suction device movable along water body bottom for water filtering from said water body
Inventor: FISCHMANN TORRES FERNANDO BENJAMIN
IPC: B01D21/01
Filed: 2009-03-11
Abstract: The invention comprises an efficient method for water filtering in a water body where the water of the water body is not filtered entirely but a small volume of water, wherein the method includes the following steps: (a) emitting ultrasonic waves into the water body; (b) addition of flocculant into the water; (c) treatment of the water body bottom by a suction device that sucks water flow with flocculated particles and pumps it to a discharge header; (d) filtering of the suction device discharge flow downstream said discharge collector; and (e) return of the filtered flow to the water body. The invention further includes the suction device used in said efficient filtering method.
Patent EA-026237-B1 (EA)
Title: Composition for strengthening incompetent rocks in a near-wellbore zone
Inventor: ISMAILOV FAKHREDDIN SATTAR OGLY
IPC: C09K8/56
Filed: 2014-12-25
Abstract: The invention is related to oil- and gas-producing industry and can be used in conduction of repair and recovery operations for strengthening near-wellbore zones of sandy wells. The objective of the invention is provision of a cementing material for strengthening incompetent rocks in a near-wellbore zone that would promote strength and expansion in volume. Said objective is attained by that a composition for strengthening incompetent rocks in a near-wellbore zone consisting of cement, liquid glass, aluminium powder and water includes, as aluminium powder, nanosized aluminium powder, and further includes ferrochrome lignosulphonate (FCLS) with the following proportion of ingredients, wt.%: cement: 60.1476-65.8426; liquid glass: 0.7518-0.8231; nanosized aluminium powder: 0.0009-0.0046; ferrochrome lignosulphonate (FCLS): 0.00015-0.4607; water: the balance.
Patent EA-030132-B1 (EA)
Title: Temperature controlled valves
Inventor: MILLER MARK KENNETH
IPC: F16K31/00
Filed: 2014-01-03
Abstract: A controller opens or closes a valve in response to the ambient temperature crossing a threshold value, for example to prevent the continued supply of water to pipes that might have frozen and burst. An output shaft (4) acts on a stem of the valve to rotate it between the open and closed positions. A clock spring (8) biases the output shaft towards one of those positions but is restrained by a latch (28) until a thermal actuator (30) operates mechanically to release the latch in response to a change in temperature. The latch may be a pawl (28) acting on a ratchet gear (22) that allows the output shaft (4) to rotate in one direction but not the other. The ratchet gear (22) may be mounted on an input shaft (14), which is connected to the output shaft (4) through a gear train (16-19) to give a mechanical advantage when turning the output shaft (4) against the force of the spring (8).
Patent EA-033259-B1 (EA)
Title: Oral care composition
Inventor: LI XIAOKE
IPC: A61K8/29
Filed: 2014-09-02
Abstract: An oral care composition is disclosed comprising calcium silicate in an amount from 0.1 to 50% by weight of the composition and high refractive index composite particles in an amount from 0.25 to 60% by weight of the composition, wherein the high refractive index composite particle comprises a first component core and a second component coating, and wherein the first component core comprises a metal oxide selected from zinc oxide, titanium dioxide, zirconium dioxide or a mixture thereof and the second component comprises the element calcium. The refractive index of the composite particles is in the range from 1.9 to 4.0, wherein the refractive index is quoted at a temperature of 25°C and a wavelength of 589 nm. The calcium silicate and high refractive index composite particles are present in the composition at a calcium silicate to composite particles weight ratio of 1:10 to 2:1. The calcium silicate consists essentially of calcium oxide and silica, or the calcium silicate is calcium silicate hydrate, consisting essentially of calcium oxide, silica and water.
Patent EA-039479-B1 (EA)
Title: Herbicide combinations comprising glufosinate and indaziflam
Inventor: OESER JOERG
Filed: 2016-04-25
Abstract: The invention primarily relates to specific herbicide combinations comprising (i) glufosinate and/or salts thereof and (ii) indaziflam and to compositions comprising said specific herbicide combinations. The invention further relates to a method of producing said specific herbicide combinations and compositions comprising said specific herbicide combinations. The invention also relates to the use of said specific herbicide combinations and compositions comprising said specific herbicide combinations in the field of agriculture, in particular as plant growth regulators and for controlling harmful plants or undesired plant growth, as well as to corresponding methods.
Patent EA-037391-B1 (EA)
Title: Rail mounting device and method for fixing rails to reinforced concrete railway sleeper
Inventor: RACZ ATTILA
IPC: E01B9/28
Filed: 2017-12-06
Abstract: The object of the invention is providing a rail mounting device (10) for fixing railway rails (12) to reinforced concrete sleepers (14), which device (10) has a first rail (12) non-fixing state and a second rail (12) fixing state, and which device (10) contains an anchoring element (18) fixed to the reinforced concrete sleeper (14) provided with an open or closed bracket piece (16), and a rail-clamping plate (20) partially or entirely encompassed by the bracket piece (16) of the anchoring element (18), the essence of which is that the rail-clamping plate (20) is a flexible flat plate, wherein the anchoring element (18) of the rail mounting device (10) has an upper surface which is substantially flat and which is established at an angle to the upper plane (22) of the reinforced concrete sleeper (14) in such a way that the distance between the first end of the upper surface of the anchoring element (18) closer to the rail (12) and the upper plane (22) of the reinforced concrete sleeper (14) is smaller than the distance between the second end of the upper surface of the anchoring element (18) more distant from the rail (12) and the upper plane (22) of the reinforced concrete sleeper (14), wherein in the first state of the rail mounting device (10), the rail-clamping plate (20) lies on the upper surface of the anchoring element (18), whereby the rail-clamping plate (20) is also arranged at an angle to the upper plane (22) of the reinforced concrete sleeper (14), and in the first state of the rail mounting device (10), the angle between the rail-clamping plate (20) and the upper plane (22) of the reinforced concrete sleeper (14) is between 5 to 20 and the rail-clamping plate (20) is made from a cut sheet steel having a thickness of maximum 6 mm.
Patent ES-2168948-B1 (ES)
Title: Nueva aplicacion terapeutica de la silicona.
Inventor: RUANO PUENTE BELEN
IPC: A61K31/80
Filed: 2000-03-22
Granted: 2003-11-01
Abstract: Nueva aplicación terapéutica de la silicona. La invención consiste en la utilización de la silicona, en forma fluida, tanto tipo aceite como gel y sus derivados, por vía intraarticular, tanto en articulaciones como en vainas de tendones y en bursas periarticulares. La silicona en estado fluido es capaz de proporcionar viscosidad al líquido sinovial, aumentando su capacidad de amortiguación y de distribución uniforme de las fuerzas de compresión sobre la superficie articular, siendo clínica y químicamente inerte, estable, inyectable, fácil de esterilizar, sin ningún efecto secundario.
Patent ES-2204220-B1 (ES)
Title: Sistema para ensayos en especimenes planos de resistencia al fuego con aplicacion de carga.
Inventor: SCHNEIDER SOUZA SERGIO
IPC: G01N19/00
Filed: 2001-03-12
Granted: 2005-07-16
Abstract: Sistema para ensayos en especímenes planos de resistencia al fuego con aplicación de carga, en el que se dispone un quemador, al que se enfrenta, un especimen plano que se une por un lado a una primera estructura fija, y por el otro a una cadena de carga que a su vez se une por su otro extremo a un brazo basculante dispuesto a una distancia del quemador como para que los efectos de su fuego no le afecten, una célula de carga en la cadena de carga y en las cercanías del brazo basculante, un actuador unido pivotantemente al brazo basculante y a una segunda estructura fija. De aplicación en ensayos de materiales aeronáuticos.
Patent ES-2204242-B1 (ES)
Title: Sistema para realizar transacciones de pagos mediante telefonia movil.
Inventor: VILA VERGARA CARLOS
IPC: G07F19/00
Filed: 2001-06-28
Granted: 2005-07-16
Abstract: Sistema para realizar transacciones de pagos mediante telefonía móvil. La presente invención consiste en un sistema de pagos mediante la red de telefonía móvil, basado en un servicio de mensajes cortos y en un conjunto de aplicaciones informáticas residentes en el terminal de punto de venta y en la tarjeta de identificación del usuario del terminal móvil del comprador o vendedor. El sistema soporta distintas formas de pago a efectuar en distintas entidades financieras, y contempla diversas transacciones como: selección del modo de pago, anulación/devolución, consulta de última operación, movimientos, totales o saldos, duplicados de operación, configuración del modo de pago por defecto o cambio del número de identificación personal. El sistema ofrece máxima seguridad pues: el comprador no precisa facilitar ningún dato personal al vendedor, no se precisa enviar el número de identificación personal (empleado solamente para cifrar y descifrar transacciones) y dichas transacciones son procesadaspor una entidad autorizadora que hace de intermediario entre comprador, vendedor y la entidad financiera.
Patent ES-2223236-B1 (ES)
Title: Sistema autonomo de riego.
Inventor: NAVARRO DEL ROSARIO EMILIO
IPC: A01G27/00
Filed: 2002-08-19
Granted: 2006-05-16
Abstract: Sistema autónomo de riego El objeto de la invención es un sistema formado por un conducto (2) en forma de campana de Gauss, intercalándose en la parte más alta de la campana un receptáculo (4) a modo de boya, en cuyo interior se coloca un pequeño conducto (4a) también con forma de campana y que tiene las mismas funciones de desagüe. El sistema está fijado a la parte superior e inferior del depósito mediante cuerda (6) o similar (eje de activación del riego). El depósito (1) se va llenando lentamente y cuando el agua supera el nivel del recipiente (4) se produce la entrada de agua al mismo y un hundimiento súbito que sumerge completamente la campana, permitiendo la salida del agua del depósito sin apenas resistencia. El sistema permite la impulsión del agua a intervalos y cantidades prefijadas, sin necesidad de otra fuente de energía que la propia entrada de agua al depósito (1).
Patent ES-2249078-B1 (ES)
Title: Sistema de medicion de caudal de tipo laminar.
Inventor: LOPEZ PENA FERNANDO
IPC: G01F1/36
Filed: 2003-03-20
Granted: 2006-12-16
Abstract: Sistema de medición de caudal de tipo laminar. El aparato está pensado para medir el caudal de fluidos, líquidos o gases, que circulen por conductos. Para un fluido determinado, el caudal es calculado por el propio aparato a partir de los datos geométricos del mismo y de diversas magnitudes físicas que mide. El núcleo del dispositivo está formado por una pluralidad de conductos iguales dispuestos en paralelo (1), de forma que el fluido entra por (5) y se divide en tantas partes como conductos, atravesándolos hasta la salida (6). Todos o algunos de estos conductos tienen orificios en sus paredes (2) que los comunican con tres cámaras independientes (3). El aparato incorpora unos transductores de presión y temperatura conectados a un circuito electrónico con el que calcula, en tiempo real, el caudal a partir de la medida de las diferencias de presión entre los racores (4) conectados a estas cámaras.
Patent ES-2262379-B1 (ES)
Title: Dispositivo de concentracion optica.
Inventor: SANCHEZ GONZALEZ MARCELINO
IPC: F24S23/72
Filed: 2004-02-17
Granted: 2007-11-01
Abstract: Comprende una superficie reflectante esférica (8) en la que, mediante una pintura antireflectante, se cubre un anillo de reflexión bloqueada (9), cuya circunferencia media (14) coincide con aquélla que focaliza en un punto sobre el plano receptor (13) de absorción de la energía. El dispositivo produce una distribución de flujo sobre el plano receptor (13) sensiblemente uniforme, reduciendo el gradiente térmico sobre el mismo. De especial aplicación en la captación de energía solar.