baber/WOPTO huggingface dataset:
Patent DE-68921114-T2 (DE)
Inventor: OKU TERUO
IPC: A61K31/445
Filed: 1989-08-09
Granted: 1995-06-08
Abstract: An oxaspiro[2,5]octane derivative of the formula : <CHEM>  wherein  R<1> is carbamoyl;  lower alkylcarbamoyl;  hydroxy(lower)alkylcarbamoyl;  lower alkoxy(lower)alkylcarbamoyl;  lower alkylthio(lower)alkylcarbamoyl;  lower alkoxycarbonyl(lower)alkylcarbamoyl;  lower alkylcarbamoyloxy(lower)alkylcarbamoyl;  di(lower)alkylcarbamoyl;  N-[hydroxy(lower)alkyl](lower)alkylcarbamoyl; N-[hydroxy(lower)alkyl](lower)alkylcarbamoyloxy(lower)alkylcarbamoyl;  lower alkylcarbamoyloxy(lower)alkenoyl;  N-[heterocycliccarbonyloxy(lower)alkyl](lower)alkylcarbamoyl;  cyclo(lower)alkylcarbamoyl;  arylcarbamoyl;  haloarylcarbamoyl;  protected carbamoyl;  lower alkylthiocarbamoyl;  heterocycliccarbamoyl;  ar(lower)alkenoyl;  lower alkoxycarbonyl; heterocycliccarbonyl which may have lower alkyl, hydroxy, hydroxy(lower)alkyl, lower alkoxy(lower)alkyl or lower alkoxycarbonyl;  lower alkyl;  carboxy(lower)alkyl;  protected carboxy(lower)alkyl;  ar(lower)alkyl which may have halogen or lower alkoxy;  heterocyclic(lower)alkyl;  lower alkylcarbamoyl(lower)alkyl;  hydroxy(lower)alkenoyl;  acyloxy(lower)alkenoyl; or  diacyloxy(lower)alkenoyl;  R<2> is lower alkoxy and <CHEM>  or pharmaceutically acceptable salt thereof. A process for preparing the oxaspiro [2,5] octane derivative is also described, together with a pharmaceutical composition comprising the same as an active ingredient. The compounds exhibit angiogenesis inhibitory activity and are therefore useful in the treatment of, for example, tumours, rheumatoid arthritis, diabetic retinopathy and psoriasis.
Patent DE-68924176-T2 (DE)
Inventor: DAVIS WALTER
IPC: H04B/
Filed: 1989-11-17
Granted: 1996-04-18
Abstract: A receiver (70) receives a transmitted signal having a periodic predetermined signal, a method and apparatus (99) detects a first predetermined signal. Power may be conserved during a portion of  a subsequent predetermined signal. The subsequent predetermined signal is divided into at least a first and second portion. If the first portion is detected, the subsequent predetermined signal is considered detected and power is conserved for the second portion. If the first portion is not detected, the receiver remains active for the second portion in order to detect the subsequent predetermined signal.
Patent DE-68927590-T2 (DE)
Inventor: REUNAMAEKI PAULI
IPC: C03B29/02
Filed: 1989-09-27
Granted: 1997-07-24
Abstract: PCT No. PCT/FI89/00183 Sec. 371 Date Apr. 12, 1991 Sec. 102(e) Date Apr. 12, 1991 PCT Filed Sep. 27, 1989 PCT Pub. No. WO90/03336 PCT Pub. Date Apr. 5, 1990.The present invention provides a heating, bending and cooling system for glass, which comprises a horizontally-standing bending mold located in an oven. The mold includes two or more hollow supporting elements which are separated from each other. At least one of the ends of each of the supporting elements extends out of the chamber of the oven through a plate. The upper part of the chamber of the oven includes at least one hollow upper element which acts as a heating and cooling element which can be lowered to a position above the supporting elements. The supporting elements not only support a glass sheet placed thereon but also bend the glass sheet when it is heated. The supporting elements also act as heating elements and cooling elements. In addition, the supporting elements are oscillated to keep the surfaces of the supporting elements touching the glass in constant motion.
Patent DE-69012315-T2 (DE)
Inventor: CARAMELLI GIANFRANCO
IPC: A21D2/18
Filed: 1990-01-18
Granted: 1995-04-20
Abstract: Dietetic food in the form of cracker with high contents in alimentary fibers and reduced contents in calories, including the following ingredients in the following percentages of weight: wheat meal 60-85 %, refined vegetable oil 8-16 %, glucomannan 5-25 %, malt extract 1-2,2 %, refined salt 1-2 %, yeast 0,2-0,8 %. The method includes the following steps: a) intimate blending apart glucomannan and vegetable oil; b) kneading together the other ingredients; c) leaving the knead rise for about 18 hours; d) amalgamating the blend of glucomannan and refined vegetable oil in the risen knead; e) let the whole knead rise for about 30-60'; f) superimposed in sheets of pastry and laminating the dough; g) engraving the lamina with round-die; h) depositing the lamina on the stove grating and baking it for about 3-4' at a temperature of about 220 DEG -320 DEG C.
Patent DE-69016093-T2 (DE)
Inventor: BRAAT JOSEPHUS JOHANNES MARIA
IPC: G02B13/18
Filed: 1990-05-14
Granted: 1995-08-24
Abstract: An objective lens (20) and an optical scanning device (30, 20, 50) provided with such a lens are described, of which lens both surfaces (22, 23), viewed from the object side, are concave, while the focal length is considerably smaller than its thickness (d) of along the axis and the surface (23) at the image side is aspherical. When using this objective lens, the scanning device may be very compact.
Patent DE-69023689-T2 (DE)
Inventor: MARQUET ALAIN
IPC: H04L27/10
Filed: 1990-04-23
Granted: 1996-05-02
Abstract: Communication adapter (12) for remote-action terminal (5) connected to a telephone line (3) in parallel with a telephone set (2) in order to exchange remote-action information via a remote-action network, with at least one server (4) by way of the telephone line, within a frequency band different from that utilized by the signals relating to the telephone set. The adapter is provided with a transceiver (14) transmitting binary data by frequency hopping from one to the other of two frequencies (F1 and F2) as does the network with which it communicates through rotation in precedence. It contains a remote- signalling device (15) equipped with means of controlling the transmission of signalling characteristic of observation of an absence of communication by exchange of signals, following a predetermined time lapse, between on the one hand the network, and on the other hand the transceiver with which it is associated in the communication adapter containing it. <IMAGE>
Patent DE-69027438-T2 (DE)
Inventor: SEIDMAN CHARLES
IPC: G07F17/32
Filed: 1990-09-17
Granted: 1997-02-06
Abstract: A promotional game wherein prizes are automatically awarded upon presentation of tokens bearing machine readable codes. The tokens may be identical to tokens bearing a common code, and the prizes may be awarded at random to patrons who present an appropriate token bearing this common code. Desirably, the prizes are awarded substantially immediately upon presentation of the tokens. The tokens may be product identification code symbols on packages of goods.
Patent DE-69032160-T2 (DE)
Inventor: WOOD WILLIAM
IPC: F16D13/62
Filed: 1990-04-12
Granted: 1998-11-12
Abstract: A torque regulating device (10) characterized by a disc (34) arranged to be fixedly attached to a shaft, discs (40, 50) of ultra high molecular weight polyethylene (UHMW PE) friction material, a gear wheel (44) rotatably mounted about the shaft, the discs (40, 50) being respectively disposed between the disc (34) and the gear wheel (44) and between a further disc (52) and the gear wheel means (44) such that the discs (40, 50) are clampable to the gear wheel (44), wherein the disc (40, 50) is arranged cooled by oil, in use. The UHMW PE may be replaced by ceramic material in disclosed alternative embodiments.
Patent DE-69032857-T2 (DE)
Inventor: MAITI SAMARENDRA
IPC: A61P29/00
Filed: 1990-10-05
Granted: 1999-08-05
Abstract: Derivatives of 2-spirocyclopropyl cephalosporin sulfone of the structural formula I   <IMAGE> I  are provided which are useful as potent elastase inhibitors.
Patent DE-69104092-T2 (DE)
Inventor: DALL ASTA LEONE
IPC: C07H15/236
Filed: 1991-02-20
Granted: 1995-01-26
Abstract: Process for the preparation of a 3,6'-di-N-Acyl-1-[L-(-)-4-Acylamino-2-hydroxybutyryl] kanamycin A, wherein Acyl is a N-protecting acylating group, which comprises reacting kanamycin A with an aluminum salt in an inert organic solvent, treating the aluminum complex thus obtained with a N-acylating agent and acidifiying the reaction mixture, as such or after having removed the complexing aluminum in basic medium and isolated the 3,6'-di-N-Acyl-kanamycin A, to pH 6, treating the protonated 3,6'-di-N-Acyl-kanamycin A, in form of a salt thereof, with an active derivative of L-(-)-4-Acyl-amino-2-hydroxybutyric acid, wherein Acyl is a N-protecting group preferably identical with that which protects the amino groups in the positions 3 and 6' of kanamycin A, and isolating the product thus obtained by simple correction of the pH.
Patent DE-69107910-T2 (DE)
Inventor: SOURLIER PASCAL
IPC: B22C9/02
Filed: 1991-06-11
Granted: 1995-06-29
Abstract: In this mould, the sum of the areas of the cross-sections of the runners (30) in service is, at at least one casting instant, greater than the area of the cross-section of the casting pool (28), or at least of the same order as this area. This makes it possible to slow down the metal during its passage in the runners and thus to obtain non-turbulent filling of the impressions. 
<??>Application to the multi-stage moulding of thin-wall castings. 
<IMAGE>
Patent DE-69121675-T2 (DE)
Inventor: CANAL TIZIANA
IPC: A61K38/27
Filed: 1991-11-15
Granted: 1997-03-06
Abstract: Pharmaceutical compositions in the form of particles comprising a biodegradable polymer and/or a polysaccharide jellifying and/or bioadhesive polymer, an amphiphilic polymer, an agent modifying the interface properties of the particles and a pharmacologically active substance. Said compositions exhibit improved biocompatibility features and allow a controlled release of the active substance.
Patent DE-69131204-T2 (DE)
Inventor: BROWN SCOTT
IPC: A61K38/43
Filed: 1991-11-04
Granted: 1999-12-23
Abstract: Prothrombin time reagents are provided which comprise novel liposome compositions in which tissue factor is associated with an inserted into the phospholipid bilayer of the liposomes. Methods for their preparation are also provided. The liposome compositions may be adjusted to allow maximum coagulant activity and sensitivity to extrinsic coagulation factors.
Patent DE-69132832-T2 (DE)
Inventor: ZUFLE T TYLER
IPC: B32B7/02
Filed: 1991-02-28
Granted: 2002-04-11
Abstract: A soft body armor in which a combination of dissimilar materials is utilized to produce a synergistic result as compared to utilization of a single type of material. The superior result provides increased resistance to penetration of the soft body armor by a projectile such as a bullet or other ballistic projectile. The dissimilar materials are arranged in a plurality of layers or plies of anti-ballistic material which can be utilized in various arrangements for protecting individuals and property from injury or damage from a projectile or other ballistic missile.
Patent DE-69133066-T2 (DE)
Inventor: HERRERA MARTINEZ LUIS SATURNIN
IPC: C12N15/16
Filed: 1991-01-16
Granted: 2003-03-06
Abstract: The present invention provides a highly efficient method for the expression of heterologous genes, using as the host an auxotrophic his3 mutant of strain BKM-90 of Pichia pastoris and as recombinant DNA for the transformation thereof an integrative vector which contains a functional selection marker of Saccharomyces cerevisiae, the promotor of the alcohol oxidase gene (AOX1) of the yeast itself, as the transcription terminator that of glyceraldehyde 3-phosphate dehydrogenase (GAP) of S. cerevisiae, or that which is carried by the heterologous gene to be expressed, and another sequence homologous to the genome of Pichia pastoris which serves for the integration thereof. The expression vectors used further contain a heterologous gene bound to the signal peptide of the sucrose invertase gene (SUC2) of S. cerevisiae. This method guarantees that the polypeptide products are recoverable under controllable conditions and with high yields. The strains according to the present invention can be used for the large-scale production of pharmaceutical products or of enzymes of industrial interest.
Patent DE-69202841-T2 (DE)
Inventor: SAXTON JOHN EDWARD
IPC: B67D7/76
Filed: 1992-08-26
Granted: 1995-10-19
Abstract: This invention relates to an improved fuel dispenser 20 comprising a gas detector 36 responsive to the presence of gas within the fuel. The gas detector provides an electrical signal indicative of the presence or absence of gas to a computer 32 which controls a valve 27, and thus the dispensing of fuel in dependence upon the signal received from the gas detector 36. <IMAGE>
Patent DE-69207836-T2 (DE)
Inventor: MARTIN GERARD
IPC: C10L9/02
Filed: 1992-06-26
Granted: 1996-05-30
Abstract: Process for the treatment of industrial and/or household waste, comprising especially a drying stage, a stage of thermolysis of the waste and a stage of chloride removal by washing the solids originating from the thermolysis. According to the invention the said thermolysis is carried out by direct contact of the waste with hot gases which have a low oxygen content. <IMAGE>
Patent DE-69212636-T2 (DE)
Inventor: SO REBECCA SUI-CHUN
IPC: C09K15/34
Filed: 1992-11-11
Granted: 1996-12-05
Abstract: A process for preparing an antioxidant which comprises extracting tea leaves with water and then fractionating the extract by means of liquid chromatography using water as the eluant.
Patent DE-69215825-T2 (DE)
Inventor: CLOUTIER JEAN-GUY
IPC: B65H7/04
Filed: 1992-07-10
Granted: 1997-06-12
Abstract: A self-actuated book section feeder (20) for use to feed automatically book sections to an apparatus for binding these sections together. This feeder comprises a table (42); a continuous conveyor (22) mounted on the table (42); a motor (88) secured to the table (42) for driving the conveyor (22); and a detector (54) mounted on the table (42) and connected to the motor (88) via a relay (92) for actuating and stopping the motor (88). In use, the detector (54) senses the presence or absence of book sections at the delivering end (53) of the conveyor (22), and then automatically actuate or stop the continuous conveyor (22) to bring more book sections. <IMAGE>
Patent DE-69304291-T2 (DE)
Inventor: SCHULZ JENS
IPC: B31F1/28
Filed: 1993-10-22
Granted: 1997-01-23
Abstract: The apparatus for limiting adhesive width comprises a first device for detecting the instantaneous position of the edges of a first strip (web) element passing via a first guide cylinder. This device controls a second device monitoring the position and the width of the adhesive (13) collected by a rotary roller/gluing machine (12) dipping into a tank of adhesive (16) and then depositing this adhesive on a second strip element (5) passing around a second guide cylinder (10). The second device comprises a pair of scrapers (34), each being held perpendicularly against the roller/gluing device by means (26, 24, 22, 18, 40, 42) monitoring its position along the edge of this roller/gluing device (12) as a function of the reading of the first device so that the inner edge of the adhesive strip (13') lifted by this pair of scrapers (34) is analogous to the position of the corresponding edge (3') of the first strip element. <IMAGE>
Patent DE-69313088-T2 (DE)
Inventor: BACON EDWARD R
IPC: C07C255/55
Filed: 1993-11-26
Granted: 1998-01-29
Abstract: Compounds having the structure <CHEM> wherein (Z &rparstr& COO is the residue of an iodinated aromatic acid;     n is an integer from 0 to 6; R<1> and R<2> are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy or aryloxy; R<3> and R<4> are independently H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy, acylamino, acetamidoalkyl, COO-alkyl and cyano; Q represents the atoms necessary to complete a carbocyclic or heterocyclic unsaturated mono- or bicyclic aromatic ring; and R<5> is H, alkyl, cycloalkyl, aryl, aralkyl, alkoxy, aryloxy, halogen, hydroxy, amino, acylamino, alkoxyalkyl, fluoroalkyl, acetamidoalkyl, COO-alkyl, cyano, carboxamido, sulfonate, sulfonamido, ureido, or carbamyl are useful as contrast agents in x-ray imaging compositions and methods for x-ray diagnostic imaging.
Patent DE-69314620-T2 (DE)
Inventor: SOMMAZZI ANNA
IPC: C08G67/02
Filed: 1993-02-06
Granted: 1998-03-26
Abstract: Process for preparing straight, alternate polymers based on carbon monoxide and at least one olefin, which comprises causing carbon monoxide and the olefin to react in the presence of:     (a) a catalyst of general formula (I):    [Pd(chel)(chel')]<+><+>[A<->]2   (I> wherein chel and chel', which may be the same, or different from each other, represent a bidentate chelating agent and A<-> stands for an anion of an acid having a pKa smaller than 6; and (b) optionally, an organic oxidizer agent.
Patent DE-69324645-T2 (DE)
Inventor: FANGET BERNARD
IPC: A61K38/00
Filed: 1993-10-07
Granted: 1999-12-30
Abstract: The HAV virus is multiplied on competent cells, the infected cells are lysed, the supernatant is collected and purification is performed by a chromatographic operation on an anion-exchange support and a gel filtration operation, the purification operations being carried out in the presence of a detergent and the chromatographic operation being carried out under conditions in which the virions or viral capsids are retained and which are subsequently eluted.
Patent DE-69334066-T2 (DE)
Inventor: ROBERTS MARK
IPC: A61P31/04
Filed: 1993-04-28
Granted: 2007-05-03
Abstract: The invention provides the use of an antigen which is a mucosally immunogenically active substance comprising the 50kD C fragment of tetanus toxin, an immunogenic fragment thereof, or a derivative thereof formed by amino acid deletion, substitution or insertion for the manufacture of a vaccine composition for administration to a mucosal surface to induce an immune response in the mucosal surface against tetanus infection. The vaccine composition preferably contains the P.69 outer membrane protein of B.pertussis, and B.pertussis filamentous haemaglutiuin. The invention also provides vaccine compositions per se and a method of treating tetanus and optionally whooping cough using the vaccine compositions.
Patent DE-69407343-T2 (DE)
Inventor: GRAZIOLI VITTORIO
IPC: G09F3/04
Filed: 1994-05-27
Granted: 1998-06-10
Abstract: The method for making a graphic representation on objects made of a polyolefin polymer, consists of printing a graphic representation on a face of a first film made of a stretched polyolefin polymer, associating the first film with a second film having a lower melting point than that of the first film, in order to obtain a membrane formed by the associated first and second films containing the graphic representation between them, transferring the membrane inside an injection mold and injecting a polyolefin polymer in the mold for forming the object, obtaining at least a partial melting of the second film so that the membrane forms one body with said object.
Patent DE-69408942-T2 (DE)
Inventor: CEVASCO ALBERT ANTHONY
IPC: C07C221/00
Filed: 1994-11-18
Granted: 1998-06-25
Abstract: There is provided an improved method for the production of o-aminophenyl ketones of formula I wherein R is C3-C6cycloalkyl or C1-C6haloalkyl. <CHEM> There is also provided an effective method for the preparation of the formula I compound o-aminophenyl cyclopropyl ketone via the dehydrohalogenation of 1-(o-aminophenyl)-4-halo-1-butanone in the presence of a base and a phase transfer catalyst. Compounds of formula I are key intermediates in the manufacture of sulfamoyl urea herbicides.
Patent DE-69411056-T2 (DE)
Inventor: WOOLERY MICHAEL R
IPC: C22B34/22
Filed: 1994-03-11
Granted: 1999-01-07
Abstract: High yields of vanadium containing virtually no nickel or magnesium are obtained from natural bitumen ash consisting of up to 5% carbon, more than 95% of water-soluble compounds of vanadium, nickel and magnesium by mixing the ash with water to produce a 20% solids slurry of pH below 6.5 and temperature of 80-85 DEG  C oxidizing any reduced vanadium in the slurry and then separating and removing the resulting polyvanadate precipitate from the liquid phase containing substantially all the nickel and magnesium values of the ash.
Patent DE-69415032-T2 (DE)
Inventor: PEDERSEN LARS
IPC: A63H33/04
Filed: 1994-09-21
Granted: 1999-06-10
Abstract: PCT No. PCT/DK94/00356 Sec. 371 Date Mar. 19, 1996 Sec. 102(e) Date Mar. 19, 1996 PCT Filed Sep. 21, 1994 PCT Pub. No. WO95/08380 PCT Pub. Date Mar. 30, 1995A toy element having a thin, flexible material as well as a holder for it is provided. The toy element may be used in the construction of a doll house for which it constitutes a curtain and the suspension, in the form of a rod, for the curtain. An elongated cavity having a longitudinal slot through which the flexible material extends is provided in the holder. A locking part couples to the holder and secures the rod holding the curtain in position.
Patent DE-69420194-T2 (DE)
Inventor: BOROWSKI RICHARD
IPC: F16C33/74
Filed: 1994-06-10
Granted: 1999-12-30
Abstract: A labyrinth type seal assembly having one or more controlled porosity elements retained in the labyrinth pathway between relatively rotatable seal elements. Preferably the controlled porosity elements are formed of open celled foam material such as polyurethane. The controlled porosity elements assist in preventing the ingress of contaminating solid or liquid materials, the loss of sealed materials and the flooding or overloading of drain ports. <IMAGE>
Patent DE-69426306-T2 (DE)
Inventor: ERTEL KEITH D
IPC: A61K31/445
Filed: 1994-09-28
Granted: 2001-06-07
Abstract: PCT No. PCT/US94/10972 Sec. 371 Date Jul. 3, 1996 Sec. 102(e) Date Jul. 3, 1996 PCT Filed Sep. 28, 1994 PCT Pub. No. WO95/11677 PCT Pub. Date May 4, 1995The present invention is directed to a chemically stable pharmaceutical composition containing ibuprofen in combination with terfenadine, wherein the oxidation of terfenadine to terfenadone is prevented by the presence in the composition of an  alpha -hydroxy carboxylic acid.
Patent DE-69427225-T2 (DE)
Inventor: MAIENFISCH PETER
IPC: A01N43/58
Filed: 1994-03-26
Granted: 2001-12-06
Abstract: Compounds of formulawhereinA is an unsubstituted or substituted aromatic or non-aromatic, monocyclic or bicyclic heterocyclic radical wherein a ring nitrogen atom may have been replaced by a groupR1 is hydrogen or C1-C3alkyl;R2 is hydrogen or C1-C3alkyl;R3 is hydrogen, an unsubstituted or substituted C1-C3-C6alkyl, C6cycloalkyl, C2-C6alkenyl or C2-C6alkynyl group, or C(=O)-R5,R5 is C1-C4alkyl, C1-C4alkoxy, an unsubstituted or substituted phenyl, phenoxy or benzyloxy group, or N(R6)2,each R6, independently of the other, is hydrogen, C1-C4alkyl or unsubstituted or substituted phenyl,X is CH-NO2, N-CN or N-NO2 andn is from 1 to 3,in free form or in salt form, and, where appropriate, tautomers of those compounds and the salts thereof, can be used as agrochemical active ingredients and can be prepared in a manner known per se.
Patent DE-69432055-T2 (DE)
Inventor: STADDON JAMES MARTIN
IPC: A61K33/24
Filed: 1994-11-18
Granted: 2003-11-06
Abstract: Permeability of the blood-brain barrier and other physiological barriers can be modulated by the degree of tyrosine phosphorylation of proteins. Agents which promote tyrosine protein dephosphorylation reduce the permeability of the blood-brain barrier and those which promote phosphorylation increase permeability. Increasing blood-brain barrier permeability is useful in delivering drugs having a desired effect upon the central nervous system; decreasing blood-brain barrier permeability and other physiological barrier permeability is useful in preventing undesired compounds reaching the CNS and in certain clinical conditions.