Patent SG-11201900565R-A (SG)
Title: New use of n,n-bis-2-mercaptoethyl isophthalamide
Inventor: HALEY BOYD EUGENE
IPC: A61K45/06
Filed: 2017-08-04
Abstract: ASTVehicle n= AST NBMI n=10 p=0.00204 ALT Vehicle n=13 ** * 952 _AMMO ALT NBM1 n=10 p=0.00006 8507 ** 753 14511 16000 14000 12000 10000 8000 6000 4000 2000 0 O O cc O O (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 February 2018 (08.02.2018) WIPO I PCT onion OH oIo01101OH100IIIIImiI10111110m0IIIIII (10) International Publication Number WO 2018/025049 Al (51) International Patent Classification: A61K 45/06 (2006.01) A61K 31/167 (2006.01) A61K 31/166 (2006.01) (21) International Application Number: PCT/GB2017/052306 (22) International Filing Date: 04 August 2017 (04.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1613535.2 05 August 2016 (05.08.2016) GB (71) Applicant: EMERAMED LIMITED [IE/IE]; Trinity House, Charleston Road, Ranelagh, Dublin 6 (IE). (72) Inventors: HALEY, Boyd Eugene; 119 Burnside Drive, Nicholasville, Kentucky 40356 (US). KLINGBERG, Rag- nar Axel Theodor; Brantingsgatan 42, 115 35 Stockholm (SE). (74) Agent: MCNEENEY, Stephen Phillip; Potter Clarkson LLP, The Belgrave Centre, Talbot Street, Nottingham NG1 5GG (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: NEW USE OF N,N-BIS-2-MERCAPTOETHYL ISOPHTHALAMIDE Liver enzymes 24hrs after 200mg/kg Paracetamol i.p. w/o synchron NBMI 680 mg/kg oral dose (U/L) Figure 6 (57) : There is provided the compound N,N-bis-2-mercaptoethyl isophthalamide (NBMI), or a pharmaceuticaliy-acceptable salt and/or derivative thereof, for use in the treatment or prevention of paracetamol toxicity. Such compounds have particular utility in the treatment or prevention of acute liver failure associated with paracetamol toxicity. [Continued on next page] WO 2018/025049 Al MIDEDIMOMMIONE1011111100IIMMEHOM Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))