Patent SG-11201804957V-A (SG)
Title: Neoantigen identification, manufacture, and use
Inventor: YELENSKY ROMAN
IPC: A61P35/00
Filed: 2016-12-16
Abstract: WO 17 / 106638 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/106638 Al 22 June 2017 (22.06.2017) WIPO I PCT (51) International Patent Classification: A61K 9/10 (2006.01) A61K 39/39 (2006.01) A61K 35/15 (2015.01) A61K 39/395 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/US2016/067159 (22) International Filing Date: 16 December 2016 (16.12.2016) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/268,333 16 December 2015 (16.12.2015) US 62/317,823 4 April 2016 (04.04.2016) US 62/379,986 26 August 2016 (26.08.2016) US 62/394,074 13 September 2016 (13.09.2016) US 62/425,995 23 November 2016 (23.11.2016) US (71) Applicant: GRITSTONE ONCOLOGY, INC. [US/US]; 5858 Horton Street, Suite 210, Emeryville, CA 94608 (US). (72) Inventors: YELENSKY, Roman; c/o Gritstone Oncology, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Inc., 5858 Horton Street, Suite 210, Emeryville, CA 94608 (US). DERTI, Adnan; c/o Gritstone Oncology, Inc., 5858 Horton Street, Suite 210, Emeryville, CA 94608 (US). BU- LIK-SULLIVAN, Brendan; c/o Gritstone Oncology, Inc., 5858 Horton Street, Suite 210, Emeryville, CA 94608 (US). BUSBY, Jennifer; c/o Gritstone Oncology, Inc., 5858 Horton Street, Suite 210, Emeryville, CA 94608 (US). (74) Agents: WHITEHEAD, Andrew, P. et al.; Fenwick & West LLP, 801 California Street, Mountain View, CA 94041 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (54) Title: NEOANTIGEN IDENTIFICATION, MANUFACTURE, AND USE 1111111111111101110101011111010111110 III 0101101111111111101110111111111110111111 Patient 110 Candidate Neoantigen Sequences 114 Presentation Identification System 160 Presentation Information 165 Vaccine 118 FIG. 2A (57) : Disclosed herein is a system and methods for determining the alleles, neoantigens, and vaccine composition as de- termined on the basis of an individual's tumor mutations. Also disclosed are systems and methods for obtaining high quality sequen- cing data from a tumor. Further, described herein are systems and methods for identifying somatic changes in polymorphic genome data. Finally, described herein are unique cancer vaccines.