Patent SG-11201901950T-A (SG)
Title: Methods of treating immune disorders using pd-1 binding proteins
Inventor: CHAN HENRY
IPC: C07K16/28
Filed: 2017-09-18
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111110B01110101011111011101001111111011100111011111011111011011# Organization International Bureau (10) International Publication Number (43) International Publication Date ••00\"\" WO 2018/053405 Al 22 March 2018 (22.03.2018) WIP0 I PCT (51) International Patent Classification: (74) Agent: WEISSER, Tamera, M. et al.; Jones Day, 250 C07K 16/28 (2006.01) Vesey Street, New York, NY 10281-1047 (US). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/US2017/052021 kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 18 September 2017 (18.09.2017) CA, DZ, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (25) Filing Language: English HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (26) Publication Language: English KR, MG, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (30) Priority Data: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 62/396,736 19 September 2016 (19.09.2016) US SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: CELGENE CORPORATION [US/US]; 86 Morris Avenue, Summit, NJ 07901 (US). (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (72) Inventors: CHAN, Henry, H.; 18787 Heritage Drive, GM, Poway, CA 92064 (US). HUR, Eun, Mi; 214 Delaware UG, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Street, Westfield, NJ 07090 (US). KHATTRI, Roli; 9990 TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Scipps Vista Way, Unit 88, San Diego, CA 92131 (US). LE-EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, — UNG, Monica; 2755 Havasupai Avenue, San Diego, CA ego, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 92117 (US). RINGHEIM, Garth, E.; 806 Taggert Drive, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Belle Mead, NJ 08502 (US). SCHAFER, Peter, H.; 237 KM, Monroe Avenue, Belle Mead, NJ 08502 (US). ML, MR, NE, SN, TD, TG). = Title: METHODS OF TREATING IMMUNE DISORDERS USING PD -1 BINDING PROTEINS — (54) = = = ---0- WV 481 = PD1AB-1 MDX 4111 PD1AB-2 — PDIAB-1 PD1AB-3 PDIA8-2 -4 , --PD1AB-4 = = PDIA8-6 ALPD1A8-5 A isotype control A isotype control * 10104 PD—L1 —DyL.650 * 10nM PD—L1-0/1140 = 2500 2500 = = = m 2000 200CF = = 4. 1500 'T' 1500 Zi 1000 i 1000 — = 500 • 0 0 —1 —10 —9 —8 —7 —6 —11 —10 —9 —8 — 7 I-1 to © ii- M to © Log [Antibody, M] FIG. lA Log [Antibody, IQ FIG. 1B 00 1-1 (57) : Provided herein are methods for managing, treating, or preventing immune disorders, such as autoimmune diseases, C:::: ) using proteins that specifically bind to Programmed Death- 1 (PD-1) and modulate the expression and/or activity of PD-1. ei C [Continued on next page] WO 2018/053405 Al MIDEDIMOMMIDIREIERIENIIIMMOIREHEM# Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt amendments (Rule 48.2(h)) of — with sequence listing part of description (Rule 5.2(a))