Patent SG-11201811554S-A (SG)
Title: Antisense oligonucleotides for modulating htra1 expression
Inventor: IACONE ROBERTO
IPC: C12N15/113
Filed: 2017-06-28
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111011111111101 IIIIIIIII101111101001H0111010111111111111110111111011110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2018/002105 Al 04 January 2018 (04.01.2018) W I PO I PCT (51) International Patent Classification: (84) Designated States (unless otherwise indicated, for every C12N 15/113 (2010.01) A61P 27/02 (2006.01) kind of regional protection available): ARIPO (BW, GH, (21) International Application Number: GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, PCT/EP2017/065937 UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (22) International Filing Date: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 28 June 2017 (28.06.2017) MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (25) Filing Language: English KM, ML, MR, NE, SN, TD, TG). (26) Publication Language: English Published: (30) Priority Data: — with international search report (Art. 21(3)) 16177508.5 01 July 2016 (01.07.2016) EP — with sequence listing part of description (Rule 5.2(a)) 17170129.5 09 May 2017 (09.05.2017) EP (71) Applicant (for all designated States except US): F. HOFF- MANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124, 4070 Basel (CH). (71) Applicant (for US only): HOFFMANN-LA ROCHE INC. [US/US]; Overlook at Great Notch, 150 Clove Road, 8th Floor, Suite 8 - Legal Department, Little Falls, New Jer- sey 07424 (US). — = Inventors: IACONE, Roberto; c/o F. Hoffmann-La Roche (72) AG, Grenzacherstrasse 124, 4070 Basel (CH). HAGE- = DORN, Peter; c/o Roche Innovation Center Copenhagen _ A/S, Fremtidsvej 3, 2970 Horsholm (DK). KAMMLER, Susanne; c/o Roche Innovation Center Copenhagen A/S, Fremtidsvej 3,2970 Horsholm (DK). OTTOSEN, Soren; c/ = o Roche Innovation Center Copenhagen A/S, Fremtidsvej 3, 2970 Horsholm (DK). TRAUSTASON, Sindri; c/o Roche = _= Innovation Center Copenhagen A/S, Fremtidsvej 3, 2970 Horsholm (DK). HUDLEBUSCH, Heidi; c/o Roche limo- vation Center Copenhagen A/S, Fremtidsvej 3, 2970 flor- sholm (DK). PEDERSEN, Lykke; c/o Roche Innovation Center Copenhagen A/S, Fremtidsvej 3, 2970 Horsholm = = — = (DK). — _ Agent: TURNER, Mark; Grenzacherstrasse 124, 4070 (74) Basel (CH). = Designated States (unless otherwise indicated, for every = (81) = kind of national protection available): AE, AG, AL, AM, = AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, — CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, = — 1-1 kr) 0 MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 1-1 N i © © CO\" (54) Title: ANTISENSE OLIGONUCLEOTIDES FOR MODULATING HTRA1 EXPRESSION 1-1 0 (57) : The present invention relates to antisense oligonucleotides (oligomers) that are complementary to HTRA1, leading N i to modulation of the expression of HTRA1. Modulation of HTRA expression is beneficial for a range of medical disorders, such as 0 macular degeneration, e.g. age-related macular degeneration.