baber/WOPTO huggingface dataset:
Patent AU-2018266911-C1 (AU)
Title: Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
Inventor: WANG GUOQIANG
IPC: A61K31/444
Filed: 2018-05-14
Granted: 2022-10-20
Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, ester, stereoisomer, tautomer, solvate, hydrate, or combination thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcohol steatohepatitis disease (NASH).
Patent RU-2174103-C1 (RU)
Title: Method of water treatment
IPC: C02F101/30
Filed: 2000-01-10
Granted: 2001-09-27
Abstract: FIELD: environment control; methods of cleaning natural water and sewage from toxic organic admixtures; reduction of organic compounds in water. SUBSTANCE: water is treated with plasma of electric discharge formed in gaseous phase above layer of fluid. Plasma is excited above surface of hydrophilic inert material continuously impregnated by treated liquid at density of current discharge of 1-10 mkA/sq.cm and voltage of 5-15 kV. EFFECT: enhanced efficiency. 1 tbl
Patent RU-2160602-C1 (RU)
Inventor: BUKHTIJAROVA M G
IPC: A61P43/00
Filed: 2000-03-06
Granted: 2000-12-20
Abstract: FIELD: medicine. SUBSTANCE: method involves additionally including therapeutic doses (3-4 g per day) of oxygen- lipid-protein-carbohydrate complex Spirulina Platensis into a therapy scheme to achieve adequate fetus growth dynamics in performing ultrasonic scanning (not less than 2 weeks). Next, supporting doses (1.5-2 g daily) are taken until day of birth comes. EFFECT: reduced perinatal losses.
Patent RU-2166140-C1 (RU)
Inventor: BOVSHOVSKIJ S Z
IPC: F16H41/30
Filed: 2000-04-07
Granted: 2001-04-27
Abstract: FIELD: power engineering industry. SUBSTANCE: invention relates to hydraulic system of vehicle torque converter. Hydraulic system of torque converter includes indirect-action safety valve and valve distributor. Input of indirect-action safety valve is coupled to meridional cavity of torque converter through channel of working fluid removal from torque converter. The first output is coupled to the first input of valve distributor and the second output to reactor wheel overrunning clutch. The second input of valve distributor is coupled to output of transducer of output shaft rotational speed. The first output of valve distributor is coupled to hydraulic transmission casing and the second output, to safety valve. EFFECT: extended range of high efficiency values, compact and reliable construction. 4 dwg
Patent RU-2174999-C1 (RU)
Inventor: GERASIMENKO E O
IPC: C11B3/00
Filed: 2000-05-12
Granted: 2001-10-20
Abstract: FIELD: food industry. SUBSTANCE: in a method of refining hard-refinable vegetable oils, involving neutralization of hydrogenated oil with alkali reagent, separation of resulting mixture into neutralized oil and soap stock, and washing of neutralized oil, neutralization and bleaching are carried out simultaneously by treating hydrogenated oil at 55-65 C with sodium silicate aqueous solution having concentration 200-250 g/l in amounts required to neutralize free fatty acid plus 5-10% excess. Mixture of neutralized oil and soap stock is affected by alternate rotating electromagnetic field with magnetic induction 0.2-0.4 Tl at 55-65 C in treatment zone and then separated in thin layer (20-25 mm) at flow velocity 4-6 m/s. EFFECT: improved oil quality and increased its yield. 3 tbl, 3 ex
Patent RU-2177092-C1 (RU)
Title: Method of producing sealing made from extended graphite
Inventor: ULANOV G A
IPC: F16J15/30
Filed: 2000-06-05
Granted: 2001-12-20
Abstract: FIELD: producing sealings of high pressure, particularly, producing locking rings for rods of stop-control valves. SUBSTANCE: method contains producing hollows in bend by means of bevel wheels. Before producing the hollows the bend made of extended graphite is applied with metal foil of determined width and thickness. The tooth of the wheel has dimension of the height. EFFECT: provided radial deformation of extended graphite in a given direction. 7 cl, 9 dwg
Patent RU-2180277-C1 (RU)
Title: Method for flow-line production of rolled steel small bars for subsequent working them
Inventor: NIKITIN G S
IPC: B21B1/46
Filed: 2000-07-13
Granted: 2002-03-10
Abstract: FIELD: metallurgy, particularly manufacture of small rolled bars of round and square cross sections from carbonaceous constructional steels and making different parts of such rolled bars. SUBSTANCE: method comprises steps of continuous casting of billet of square cross-section bar; heating it by induction process at leveling temperature across its cross section after complete crystallization of ingot; bending billet by loop with radius 1-1.2 m; performing induction heating of billet; rolling it in combination with continuous casting process in planetary rolling mill including guiding and universal rolling stands; calibrating made rod; straightening it; cutting it by measured lengths and forming necessary parts of cut lengths of rod. According to invention, billet is cast with cross section 90-110 x 10-140 mm. Then it is heated until 850-950 C, it is reduced in guiding stand to circle with diameter 95-110 mm or to rounded square of equivalent cross section, and reduced in planetary stand to square or circle with elongation degree (17-25) while providing pauses between deformation stages no more than 0.05c. Behind planetary stand loop of rod is formed, it is cut by predetermined lengths at periodically arresting rod. Cut rod lengths are distributed at least with the use of one pointer by parallel flows for forming of them hard-wares and(or) rail cramps and(or) anticreepers. EFFECT: mass production of parts for railway roads in optimal heat- deformation modes with high efficiency and reduced power consumption.
Patent RU-2171105-C1 (RU)
Inventor: POJUROVSKAJA I JA
IPC: A61K6/884
Filed: 2000-09-07
Granted: 2001-07-27
Abstract: FIELD: medical engineering. SUBSTANCE: composition has suspension polyacrylate powder and liquid containing methyl metacrylate and acryl oligomers in mass proportion 2- 2.5:1-1.5. Mixture of ethoxylated dimethyl acrylate diphenylol propane, hexane diol 1,6-dimetacrylate, N-ethyl-N-phenyl-amino-2-hydroxypropyl metacrylate is applied as acryl oligomers. The mixture also contains polymethylsiloxane liquid. The ingredients are taken in known quantitative proportions. EFFECT: long service life and functional quality of dental prostheses. 1 tbl
Patent RU-2182863-C1 (RU)
Inventor: GAJDAROVA L L
IPC: B27N7/00
Filed: 2000-12-09
Granted: 2002-05-27
Abstract: Изобретение относится к производству древесных плит, а именно к технологии их защиты от доступа влаги. Древесные плиты покрывают композицией, содержащей фторполимер Ф-32, диметилформамид и бутилацетат. Изобретение позволяет исключить окрашивание и повысить надежность защиты торцевых поверхностей.
Patent RU-2187270-C1 (RU)
Title: Method for treating the fractures of lower limb long bones
Inventor: KARLOV A V
IPC: A61B17/66
Filed: 2001-02-05
Granted: 2002-08-20
Abstract: FIELD: medicine, orthopedics, traumatology. SUBSTANCE: implants are executed and apparatus of external fixation is applied. Bioinert implants are fixed at the place where closed contour of the mentioned apparatus has a maximum size. At the place of average size of closed contour osteoconductive implants are fixed and at the place of minimal size - osteoinductive ones. The method enables to optimize the hardness of fixation. EFFECT: higher efficiency of therapy. 1 ex, 2 dwg, 1 tbl
Patent RU-2187553-C1 (RU)
Inventor: LOGINOV O N
IPC: C12N1/20
Filed: 2001-04-11
Granted: 2002-08-20
Abstract: FIELD: biotechnology, agriculture microbiology. SUBSTANCE: strain is isolated from sandy loam soil. The isolated strain is stored in collection of Institute of biology UNTS RAN at number 182. The strain of microorganism Pseudomonas species 182 inhibits the growth of different species of phytopathogenic fungi causing root rots in plants. The strain does not induce opportunistic infections in animals or parasite in animals and humans. The strain shows the more high hydrolytic activity with respect to chitin. EFFECT: strain indicated above, enhanced chitin-hydrolyzing activity. 1 tbl
Patent RU-2197391-C1 (RU)
Title: Power press drive
Inventor: KASIMOV R I-O
IPC: B30B15/14
Filed: 2001-05-03
Granted: 2003-01-27
Abstract: FIELD: power presses for blanking and stamping parts from sheet materials. SUBSTANCE: power press drive includes drive eccentric shaft connected through eccentric bushings located on cranks of eccentric shaft for force engagement with it and connecting rods with press slide. Eccentric bushings are installed for alternating force engagement with eccentric shaft and connecting rods by means of step keys. Keyways with guides for step keys are made on internal and external surfaces of eccentric bushings, in plane of their symmetry, on side of maximum eccentricity. Keyways are also made on connecting rods internal surface and on diametrically opposite side of eccentric shaft cranks. Keys are located for displacement in installation and for locking in forced or free positions by threaded joints. EFFECT: simplified design of power press drive and reduced cost of equipment. 2 cl, 3 dwg
Patent RU-2181462-C1 (RU)
Title: Burner device
Inventor: KORDIT E A
IPC: F23D5/06
Filed: 2001-05-23
Granted: 2002-04-20
Abstract: FIELD: power engineering; automotive industry. SUBSTANCE: to increased intensity of burning and prevent coking in capillary structure of evaporating member and consequently, improved reliability and power of burner device equal number of symmetrically arranged longitudinal radial holes are made on side surface of air nozzle. Holes are arranged in two rows spaced in height on nozzle surface. Each hole of upper row is located on line equispaced from two near holes of lower row. Vortex flow shaper is used additionally. It is arranged between air feed nozzle and evaporating capillary structure which has axially symmetric surface with longitudinal holes. Holes on vortex flow shaper are displaced relative to holes on air feed nozzle through 1/2 of angle formed by two near holes of nozzle, and section of surface of vortex flow shaper between the holes has radius of curvature smaller than distance from axis of air feed nozzle to nearest element of surface of vortex flow shaper. EFFECT: improved reliability and power of burner. 3 cl, 5 dwg
Patent RU-2193011-C1 (RU)
Inventor: BURYGIN O P
IPC: C01F7/74
Filed: 2001-09-04
Granted: 2002-11-20
Abstract: FIELD: production of coagulants - aluminum sulfate possessing high coagulating ability. SUBSTANCE: process of production of coagulant in the form of liquid aluminum sulfate includes simultaneous supply of reagents - aluminum hydroxide with sulfuric acid taken in amount of no less 95% stoichiometry to reactor through vertical cylindrical mixer located in vertical part of reactor. Chemical reaction of reagents in reactor is conducted at temperature of 90-110 C with continuous mixing by anchor agitator. Prior to supply of aluminum hydroxide having moisture content not more 12% to mixer, it is mixed with water to obtain pulp with density of at least 1.3 g/cu.cm. Produced fusion cake of aluminum sulfate is diluted with water to concentration by Al 2 O 3  up to 7-8%. Process is realized by closed cycle. EFFECT: higher productivity, reduced power consumption, ecologically safe process. 3 cl, 1 tbl
Patent RU-2205955-C1 (RU)
Title: Method of mineral extraction in filled flanks of opencast
Inventor: NETSVETAEV A G
IPC: E21C41/26
Filed: 2001-11-13
Granted: 2003-06-10
Abstract: FIELD: mining industry; applicable in opencast mining of minerals, particularly, of coal. SUBSTANCE: method includes formation in filled flanks of opencast of working platform on bench having mineral outcrop to its slope; extraction of flank mineral from formed working platform with preservation of stability of flank to be filled. Formation of working platform is carried out before liquidation of bench having mineral outcrop to its slope. Extraction of mineral is performed by formation of deep extraction rooms with help of complex of bed deep mining with ladder-type conveyor. Liquidation of bench having mineral outcrop to its slope is carried out with lagging with respect to mineral extraction, at least, by five extraction rooms. Stability of filled flank of opencast may be preserved by leaving interroom pillars or by filling of worked out space of extraction rooms with overburden rocks extracted in liquidation of working platform. EFFECT: increased amount of extracted mineral without increase of volume of stripping operations, reduced volume of blasting and drilling operations, in cycle of mineral extraction. 3 cl
Patent RU-2206115-C1 (RU)
Inventor: NIKITIN S A
IPC: G03F1/70
Filed: 2002-01-08
Granted: 2003-06-10
Abstract: FIELD: electronic engineering. SUBSTANCE: maskblank has coating and resist film on glass base. Coating material is composition of general formula MbEn, where M is chromium, iron; E is nitrogen, oxygen; m and n are atomic proportions of M and E; m > 3 and n <4. Used as resist film is photoresist or electron-sensitive resist. Base- to-coating-to-resist-film thickness ratio is (1-3)•10 3 :1:(3-6). EFFECT: enhanced stability of lithographic characteristics due to mentioned preset thickness ratio. 2 cl, 1 tbl
Patent RU-2199375-C1 (RU)
Inventor: LANCHAKOV G A
IPC: B01D53/14
Filed: 2002-02-19
Granted: 2003-02-27
Abstract: FIELD: absorption drying of hydrocarbon gases; treatment of hydrocarbon gases at fields and at Manufacturing plants. SUBSTANCE: proposed method includes primary separation of gas, cooling this gas, secondary separation of gas, introduction of absorbent into gas flow after secondary separation, discharge and regeneration of used absorbent; absorbent is also introduced before cooling and secondary separation in the amount ensuring dew point of gas by moisture content after cooling by magnitude ΔT = Δτ+Δτ 2 , below average temperature T of gas after cooling, where ΔT is difference between gas temperature and its dew point by moisture content after cooling apparatus; Δτ 1  is difference between average temperature of gas after cooling apparatus and temperature of gas in the coldest tube of cooling apparatus; Δτ 2  is difference between dew point temperature and condensing temperature of gas hydrate by gas phase. Besides that, part of absorbent may be fed to gas flow before cooling and remaining part is directed for regeneration together with liquid phase separated during secondary separation. EFFECT: enhanced efficiency. 2 cl, 3 dwg, 1 tbl
Patent RU-2214112-C1 (RU)
Inventor: KVASENKOV O I
IPC: C12P1/02
Filed: 2002-04-18
Granted: 2003-10-20
Abstract: FIELD: food-processing industry. SUBSTANCE: method involves treating raw plant material with preparation produced from Mortierella pulchella micromycet biomass by predetermined process; holding; impregnating with liquefied ammonia under pressure above atmospheric value; releasing pressure to value equal to atmospheric pressure at rate providing freezing of raw material. EFFECT: eliminating of juice opalescence and increased resistance to bacteriological damage. 2 ex
Patent RU-2214493-C1 (RU)
Inventor: MAKSIMOV A M
IPC: E05B47/00
Filed: 2002-06-19
Granted: 2003-10-20
Abstract: FIELD: safety devices, applicable for locking of various objects. SUBSTANCE: the keyless code lock has a body, cross-bar and a code unit including the code disks and working locking disks with flats. In addition the lock has a source of infra-red radiation and at least one heat-to-power transducer. At least one heat-to-power transducer is engageable with the cross- bar for its displacement in the lock body and is optically linked through the code unit with the source of infra-red radiation. Besides, the lock may have at least one heat-to-power transducer installed for blocking the displacement of the cross-bar. EFFECT: enhanced level of the lock secrecy, reliability of its operation and durability, 4 cl, 10 dwg
Patent RU-2214305-C1 (RU)
Title: Catalyst and a method for producing nitrous oxide
Inventor: MOKRINSKIJ V V
IPC: B01J23/18
Filed: 2002-06-27
Granted: 2003-10-20
Abstract: FIELD: inorganic compounds technology and oxidation catalysts. SUBSTANCE: objective of invention is to provide catalyst for oxidation ammonia into nitrous oxide by oxygen or oxygen-containing gas, which catalyst would be active and selective with regard to N 2 O and contain reduced amount of active ingredient. Objective is reached by using catalyst including manganese-containing component and oxide support containing at least one of the following oxides: MgO, CaO, SrO, BaO, Al 2 O 3 , Fe 2 O 3 . said active component being a composition representing (i) mixed amorphous oxide phase with nonstoichiometric analysis: MnR x O y (0,05≤x≤2,24; 1,08≤y≤5,36) wherein R denotes bismuth and/or lanthanoid, or (ii) mixture of amorphous phase MnR x O y  and crystalline manganese-containing phase. Oxidation of ammonia in presence of above described catalyst is conducted at 300-400 C. Catalyst is also characterized by reduced bulk weight on the level of 0.65-0.7 g/cu.cm. EFFECT: reduce yield of nitrogen oxide and reduced content of active component. 7 cl, 1 tbl, 19 ex
Patent RU-2231575-C1 (RU)
Inventor: KALIMULLIN A A
IPC: H01B7/17
Filed: 2002-11-25
Granted: 2004-06-27
Abstract: FIELD: devices of cathodic protection of the oil field equipment. 
     SUBSTANCE: the invention is dealt with devices for cathodic protection of the oil-field equipment, in particular, the deep-well pump. The device for a cathodic protection of the well pump includes a station of a cathodic protection - SCP connected by an interconnect cable on a daylight surface to the casing string and to the anodic earth electrode. At that the SCP is additionally connected to the housing of the well pump by an additional current core of the electric cable for power feeding to the electric motor of the well pump. The electric cable for power feeding to the electric motor of the protected well pump is equipped with the additional current conductive core intended for connection of the well pump housing to the SCP. At that in the capacity of the additional core of the cable they use the core similar to the other cores of the electric cable and all current conductive cores of the electric cable are packed into the armor. The technical result is development of the device for a cathodic protection of the well pump sinking in the borehole without decrease of efficiency of the device operation as the well pump is sinking away from the daylight surface. 
     EFFECT: development of the device for a cathodic protection of the well pump ensuring its effective operation as sinking in the borehole. 
     4 cl, 2 dwg, 1 tbl
Patent RU-2235038-C1 (RU)
Inventor: KOZIN V M
IPC: B63B35/08
Filed: 2003-05-05
Granted: 2004-08-27
Abstract: FIELD: shipbuilding; submarine vessels breaking ice cover by resonance flexural gravitational waves. 
     SUBSTANCE: proposed device includes submarine vessel exciting resonance flexural gravitational waves during motion under ice at resonance speed and porous member mounted on upper deck in fore portion of hull and used for delivery of air beyond boundaries of ship. 
     EFFECT: enhanced efficiency of ice breaking. 
     1 dwg
Patent RU-2241078-C1 (RU)
Title: Способ выращивания монокристалла кремния из расплава
Inventor: ALEKSEEV S V
IPC: C30B29/06
Filed: 2003-06-17
Granted: 2004-11-27
Abstract: Изобретение относится к технологии получения полупроводниковых материалов для электронной техники, в частности кремния, получаемого методом Чохральского. Способ выращивания монокристалла кремния диаметром d из расплава включает формирование при остаточном давлении в камере 50-150 мм рт.ст. газового потока над расплавом, находящимся в тигле, в присутствии газонаправляющего цилиндрического экрана диаметром ⌀ ц =[(d 2  +D 2 )/2] 1/2 , где D - диаметр тигля, установленного соосно выращиваемому монокристаллу. Газонаправляющий цилиндрический экран дополнительно снабжают газоразделительным кольцевым экраном с внутренним диаметром ⌀ к =(1,2-1,4)·d, который размещают сверху газонаправляющего цилиндрического экрана соосно последнему. Газонаправляющий цилиндрический экран устанавливают и поддерживают на высоте h=[(D 2 -d 2 )/8]/⌀ ц  от поверхности расплава. Предложенный способ обеспечивает выращивание монокристаллов кремния с высокими технико-экономическими характеристиками, себестоимость получения годной продукции снижается в среднем на 15-20%. Существенно упрощается аппаратурное оснащение подготовки и проведения процесса выращивания. 1 ил.
Patent RU-2251573-C1 (RU)
Inventor: SLAVJANSKIJ A A
IPC: C13B30/02
Filed: 2003-12-23
Granted: 2005-05-10
Abstract: FIELD: sugar production from intermediates in crystallization last step. 
     SUBSTANCE: claimed method includes massecuite boiling in vacuum pan to obtain end product; massecuite rocking prior to let thereof from vacuum pan into massecuite mixer receptacle with hot water; subsequent sugar crystallization from intercrystalline massecuite solution by several-steps cooling in massecuite mixers (crystallizers). In massecuite boiling process distilled soft monoglyceride in amount of 0.004-0.008 mass % is added therein to accelerate crystal growth. During massecuite crystallization in massecuite mixers when temperature is decreased up to 58-60°C also distilled soft monoglyceride in amount of 0.002-0.004 mass % is added therein to reduce solution viscosity. 
     EFFECT: deep molasses leaching; improved condition for separation of last crystallization massecuite in centrifuge. 
     2 ex
Patent RU-2250536-C1 (RU)
Title: Solar battery
Inventor: BERKAL R I
IPC: H01L31/042
Filed: 2004-01-08
Granted: 2005-04-20
Abstract: FIELD: electrical engineering; electrical energy generation by solar-radiation-to-power conversion. 
     
     
       SUBSTANCE: proposed solar battery has panel with modules secured thereto by adhesive; these modules incorporate solar cells interconnected in series or in series-parallel with aid of switching buses. The latter are provided with thermomechanical expansion devices; shielding glass strip provided with flexible members of desired shape and size additionally glued to planar or curvilinear surface of frame is secured by means of adhesive to front surface of each solar cell. Inner space of flexible members is filled with sealing compound to form convex meniscus. Solar cells abut against flexible members and are fixed in position until sealing compound is fully polymerized. Switching buses with thermomechanical expansion devices, as well as shunting diodes are welded or soldered to rear contacts of solar cells in regions free from sealing compound. Thermomechanical expansion devices are disposed between rear end of solar cells and carrying surface of frame also in regions free from sealing compound. Solar battery is characterized in simplified design of switching system and in that battery mass is uniformly distributed over frame surface. 
     
     
       EFFECT: enhanced reliability, in-service stability of mechanical, thermomechanical and electrical characteristics, and reduced mass of solar battery. 
     
     
       1 cl, 3 dwg, 1 ex