baber/WOPTO huggingface dataset:
Patent WO-2021108619-A1 (WO)
Title: Lymphocytes t modifiés et lymphocytes infiltrant les tumeurs pour surmonter l'immunosuppression dans le micro-environnement tumoral
Inventor: FIX SAMANTHA MARIE
IPC: A61K35/17
Filed: 2020-11-25
Abstract: Des modes de réalisation de l'invention concernent des procédés et des compositions facilitant le traitement du cancer comprenant au moins le fait qu'ils concernent des thérapies contournent le micro-environnement tumoral. Dans des modes de réalisation spécifiques, des compositions sont utilisées pour une thérapie utilisant des lymphocytes infiltrant les tumeurs et/ou des lymphocytes T modifiés qui sont protégés contre l'immunosuppression du micro-environnement tumoral parce qu'ils sont modifiés afin de présenter une expression réduite ou supprimée du récepteur du facteur de croissance transformant bêta 2 et/ou du domaine des cellules I-Ig et ITIM et/ou des gènes CD7.
Patent WO-2021126634-A1 (WO)
Title: Multi-purpose signaling for a memory system
Inventor: JOHNSON JAMES
IPC: G11C11/4076
Filed: 2020-12-09
Abstract: Methods, systems, and devices for multi-purpose signaling for a memory system are described. One or more signal paths of between a host device and a memory device may be configured to support shared pathways between multiple channels and to support multiple functions. For example, a signal path may be configured to communicate a state signal for an initialization sequence of the memory device, an error signal for the memory device to indicate that errors have occurred, or a low-power signal for the host device to request that the memory device enter a low-power mode, or a combination thereof. The signal path may be shared between two or more channels of the memory device.
Patent WO-2021150313-A1 (WO)
Title: Contrastive learning for question answering (qa)
Inventor: GONG MING
IPC: G06F16/36
Filed: 2020-12-10
Abstract: The present disclosure relates to contrastive learning for question answering (QA), and proposes methods and apparatuses for providing contrastive training data. A positive example may be obtained from a training data set, the positive example comprising a first text and a second text labelled as relevant. Contrastive information may be extracted from a search log. The first text may be amended based at least on the contrastive information. The amended first text and the second text may be combined into a negative example which is contrastive to the positive example, the amended first text and the second text being labelled as irrelevant in the negative example.
Patent WO-2021119311-A1 (WO)
Inventor: BELL JOSHUA SK
IPC: G16B20/00
Filed: 2020-12-10
Abstract: Methods, systems, and software are provided for an ensemble model trained to distinguish between cancers with homologous recombination pathway deficiencies (HRD positive cancers) and cancers without homologous recombination pathway deficiencies (HRD negative cancers) based on nucleic acid sequencing data, e.g., both RNA and DNA sequencing data, generated from a cancerous tissue sample of the subject.
Patent WO-2021119425-A1 (WO)
Inventor: LIU KELVIN
IPC: C12Q1/66
Filed: 2020-12-11
Abstract: Provided herein are methods of purifying a sample containing nucleic acids to obtain isolated nucleic acids of a desired size range and methods of sequencing nucleic acids of a desired size range. The methods include a) combining a nucleic acid-containing sample with a precipitation buffer in a container to provide a precipitation mixture in which the precipitation buffer comprises water, a buffer, a salt, and polyvinyl pyrrolidinone (PVP) and/or Ficoll. The methods also include precipitating the nucleic acids in the precipitation mixture to provide a precipitated nucleic acid portion and a remaining sample portion. The precipitated nucleic acid portion predominantly comprises nucleic acid molecules above a selected size cutoff value and the remaining sample portion predominantly comprises nucleic acid molecules below the selected size cutoff value. The methods also include separating the precipitated nucleic acid portion from the remaining sample portion. Related compositions and kits are also provided herein.
Patent WO-2021173229-A1 (WO)
Inventor: YAMAMOTO BRYAN
IPC: B64G1/22
Filed: 2020-08-21
Abstract: Exemplary embodiments provided herein include connection systems in which a gripper is actuated through introduction of a material to an interior cavity. Embodiments may include more than one cavity such that deployment and actuation may be separately controlled. Additional cavities may also be used and/or selection of valves between cavities such that actuation and/or deployment may further be controlled.
Patent WO-2022093294-A1 (WO)
Inventor: WAN CHUNG CHUN
IPC: H04M1/02
Filed: 2020-10-27
Abstract: A device including a display including a main portion, a first region and a second region being in different positions within a boundary of the main portion, the first region having a first structure of light-blocking, and the second region having a second structure of light-blocking elements, a first light sensor positioned under the first region, the first light sensor being configured to capture a first image having at least one first characteristic, wherein the first characteristic depends on the first structure, a second light sensor positioned under the second region, the second light sensor being configured to capture a second image having at least one second characteristic, wherein the second characteristic depends on the second structure, and a memory including code that when executed by a processor causes the processor to generate a third image based on the first image and the second image.
Patent WO-2021262248-A1 (WO)
Inventor: MADHUR COMANDUR ASHWIN
IPC: H04W28/06
Filed: 2020-12-04
Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a wireless communication device may determine to discard a number of packets from a plurality of packets included in a packet stream. The plurality of packets may be associated with a context. The wireless communication device may determine that the number of packets to discard does not satisfy a threshold associated with the context. The wireless communication device may discard the number of packets. The wireless communication device may transmit the plurality of packets after discarding the number of packets based at least in part on the determination that the number of packets does not satisfy the threshold. Numerous other aspects are provided.
Patent WO-2021150773-A1 (WO)
Title: Methods and materials for treating nerve injury and/or promoting wound healing
Inventor: MANTO KRISTEN
IPC: A61N1/00
Filed: 2021-01-21
Abstract: This document relates to methods and materials for treating nerve injuries. For example, thermoresponsive compositions containing 4-aminopyridine (4-AP) and/or one or more derivatives of 4-AP as well as methods for using such thermoresponsive compositions as a delivery system for 4-AP and/or one or more derivatives of 4-AP ( e.g. , to treat nerve injury) are provided. This document also provides methods and materials for treating a wound ( e.g. , a skin wound). For example, compositions containing 4-AP and/or one or more derivatives of 4-AP can be administered ( e.g. , systemically administered) to a mammal having a wound ( e.g. , a skin wound) to treat the wound ( e.g. , to promote wound healing).
Patent WO-2021158702-A1 (WO)
Title: Artificial intelligence selection and configuration
Inventor: CELLA CHARLES
IPC: G06N20/00
Filed: 2021-02-03
Abstract: A system includes an opportunity mining module structured to receive input regarding an attribute of a task or a domain, and process the input to determine if an artificial intelligence system can be applied to the task or the domain, an artificial intelligence search engine structured to receive the input, and perform a search of an artificial intelligence store of a plurality of domain-specific and general artificial intelligence models and model components using the input and/or at least one selection criteria to identify at least one artificial intelligence model or model component to apply to the task or the domain, and an artificial intelligence configuration module structured to configure one or more data inputs to use with the at least one artificial intelligence model or model component.
Patent WO-2022169449-A1 (WO)
Inventor: ALSTON JR
IPC: A61M60/205
Filed: 2021-02-04
Abstract: Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that may include an inflow or outflow cannula apparatus. The inflow or outflow cannula apparatus may include a conduit having an exterior surface and an interior surface, an inlet portion arranged at a first end of the conduit including a plurality of elongate members arranged about a circumference of the inlet portion configured to deploy against a tissue wall, and a graft portion covering and arranged between the plurality of elongate members and extending along the interior surface of the conduit.
Patent WO-2021173410-A1 (WO)
Inventor: WANG XIAO FENG
IPC: H04W56/00
Filed: 2021-02-18
Abstract: A non-terrestrial network is provided that includes a satellite that transmits an orbital parameter message to a user equipment. The user equipment processes the orbital parameter message to determine a current range from the user equipment to the satellite based upon the received orbital parameter message, a timing offset and a frequency offset for an uplink transmission to the satellite.
Patent WO-2021173941-A1 (WO)
Title: Compositions de revêtement en poudre thermiquement conductrices et électriquement isolantes
Inventor: MA LIANG
IPC: C09D5/03
Filed: 2021-02-26
Abstract: La présente invention concerne une composition de revêtement en poudre comprenant un liant ; un matériau de charge thermiquement conducteur, électriquement isolant ; et, facultativement, un matériau thermoplastique et/ou un polymère coeur-écorce. La présente invention concerne également un substrat comprenant une couche de revêtement déposée à partir de la composition de revêtement en poudre de la présente invention, ainsi que des procédés de revêtement d'un substrat.
Patent WO-2022019960-A1 (WO)
Title: Toy with antimicrobial properties and method for producing same
Inventor: MATHEY MARK
IPC: D06M11/83
Filed: 2021-03-05
Abstract: The toy product of the present invention incorporates an antimicrobial agent that is introduced during the manufacturing process, to render the resultant product hypoallergenic and resistant to stains and odors during use, even after repeated washings. In a preferred embodiment, the toy product is a stuffed plush animal in which some or all of the yarn/fabric used in fabricating the toy product is treated with an antimicrobial agent during the knitting or weaving of the yarn to create the plush. While many different antimicrobial agents may be used, a preferred microbial agent is a solution containing silver nitrate, silver chloride, and/or alkyl dimethyl benzyl ammonium chloride.
Patent WO-2021178921-A1 (WO)
Inventor: LOMBARDO DAVID
IPC: H02J7/00
Filed: 2021-03-05
Abstract: A lift device includes a base assembly, a turntable assembly, and a controller. The base assembly includes multiple base assembly batteries. The turntable assembly is rotatably coupled with the base assembly through a slip ring transmission. The turntable assembly includes multiple turntable assembly batteries. The controller is configured to operate the base assembly batteries to discharge electrical energy to the turntable batteries through the slip ring transmission. The slip ring transmission is configured to both (1) drive the turntable assembly to rotate relative to the base assembly and (2) to electrically and communicably couple electrical components of the base assembly with electrical components of the turntable assembly.
Patent WO-2021188892-A1 (WO)
Title: Compositions and methods for reducing reverse packaging of cap and rep sequences in recombinant aav
Inventor: CAMPLIN BRADY
IPC: C12N15/86
Filed: 2021-03-19
Abstract: The present disclosure provides compositions including recombinant nucleic acid constructs, vectors, and host cells, and methods of their use for reducing reverse packaging of cap and/or  rep  DMA sequences in the production of recombinant adeno-associated vims (rAAV). Also provided are pharmaceutical compositions comprising an rAAV produced from a composition or method of the invention and a pharmaceutically acceptable carrier or excipient. These pharmaceutical compositions may be useful in gene therapy for the prevention or treatment of a disease, condition, or disorder in a subject.
Patent WO-2021211273-A1 (WO)
Title: Needle connectors and modular needle connectors for multi-dose drug delivery devices and methods thereof
Inventor: PIRDOBAGHI TOHID
IPC: A61J1/14
Filed: 2021-03-24
Abstract: Systems and devices described herein include multi-dose injection systems for delivering drugs, hormones, biologics, and other therapeutic agents. Systems include multiple single-injection needle connectors attachable to a reusable injector. The needle connectors include a needle having a distal end for administering the therapeutic agent to the patient and a proximal end to pierce a septum of the reusable injector. The proximal ends of the needles across the multiple needle connectors can vary such that the piercing location on the septum varies. The systems also include modular needle connectors. The modular needle connectors can include a disk rotatable within a connector body. A position of a needle within the rotatable disk changes each time the modular needle connector is connected to a reusable injector.
Patent WO-2021211297-A1 (WO)
Title: System and method for removing haziness in digital images
Inventor: ANGAMUTHU GANESAN MAHENDRA KUMAR
IPC: G06T5/00
Filed: 2021-03-31
Abstract: A method (500) for removing haziness in a digital image is provided. The method (500) includes receiving an input digital image (214) having some haze content from an image capturing device (202). The input digital image (214) is downscaled to obtain a low-resolution image. Further, a minimum intensity dark channel is determined for each local patch of the low-resolution image to obtain a dark channel image corresponding to the low-resolution image. Furthermore, a transmission map of the low-resolution image is determined based on the dark channel image. Moreover, an atmospheric light value associated with the low-resolution image is also determined. The method (500) further includes applying the determined transmission map and the atmospheric light value associated with the low-resolution image to the input digital image (214) to generate a de-hazed output image (216) and displaying the generated de-hazed output image (216) on a display unit (212).
Patent WO-2021202738-A1 (WO)
Title: Mri-based textural analysis of trabecular bone
Inventor: STEIN EMILY M
IPC: A61B5/05
Filed: 2021-03-31
Abstract: In an example method, a computer system receives one or more images of one or more bones of a patient. The one or more images are generated by a magnetic resonance imaging (MRI). The computer system determines one or more metrics indicative of an image texture of the one or more images; and determines at least one of a bone risk or a bone health of the patient based on the one or more metrics.
Patent WO-2021202999-A1 (WO)
Title: Modulated waveform treatment device and method
Inventor: KERN DALE G
IPC: A61N1/36
Filed: 2021-04-02
Abstract: A microcurrent treatment device has one or more electrodes or emitters configured for electrical communication with the surface of a subject's skin. A voltage or current supply is adapted to generate an electrical waveform or other energetic waveform for application to the skin surface, via the one or more electrodes or emitters, and a controller is configured to modulate the waveform. The controller can modulate consecutive pulses of the waveform so that the pulse width, period, frequency, amplitude or integrated amplitude of the consecutive pulses varies in a predefined, random, pseudorandom, or other aperiodic manner, or so that the pulses exhibit a degree of statistical randomness, over a predefined period. The period can cover a set of consecutive pulses defining a treatment cycle, or a continuous subset of consecutive pulses defining one or more phases of a treatment cycle.
Patent WO-2021211335-A1 (WO)
Title: System and methods for multi-links sd-wan using cellular device connections
Inventor: SINGH DALJIT
IPC: H04L1/22
Filed: 2021-04-07
Abstract: Systems and methods for multi-links software-defined wide area network (SD-WAN) using phone mobile hotspots include a network device that receives, from a client, a request to establish a connection with a data source. The network device may select, responsive to receiving the request, a connection between the network device and one of the first registered cellular device or the second registered cellular device via which the network device is to transmit network traffic corresponding to the request, the first registered cellular device and the second registered cellular device registered with the network device and having a respective cellular connection. The network device may transmit network traffic corresponding to the request from the client via the connection to the data source.
Patent WO-2021207626-A1 (WO)
Title: Controlling the slice flow of a slurry through a headbox
Inventor: PRESCOTT RALPH
IPC: D21F1/06
Filed: 2021-04-09
Abstract: A method for controlling a slice flow of a slurry having two or more component slurries through a headbox for a paper making machine includes, inputting a wire speed of the paper making machine; determining a jet velocity setpoint based on the wire speed; determining a header pressure setpoint for two or more headers to generate the jet velocity determined by the jet velocity setpoint, each header providing one of the two or more component slurries to the headbox; and controlling the slice flow by: generating a first speed command to a first slurry pump to generate a header pressure determined by the header pressure setpoint in a first header; and generating a second speed command to a second slurry pump to generate the header pressure determined by the header pressure setpoint in a second header.
Patent WO-2021211943-A1 (WO)
Title: Software-defined radio linking systems
Inventor: PAYTON JOSEPH
IPC: H04B1/00
Filed: 2021-04-16
Abstract: The disclosed invention includes methods for linking individual software-defined radios (SDR) into a cohesive network of SDRs capable of recording a sample of radiofrequency (RF) signals emitted in an RF environment. Individual SDRs communicate with an IP network, and host a linking application that executes the recording. A user identifies a lead SDR from among the SDRs, and uses the lead SDR to task participating SDRs with reference to a clock source. Also disclosed is a system of SDRs configured to be linked into a cohesive network of SDRs capable of recording a sample of RF signals emitted in an RF environment. Embodiments of the disclosed invention include co-located and dispersed SDRs. Some embodiments use SDRs organized into a mesh network. Embodiments of the disclosed invention are configured to perform total band monitoring, total band capture, RF environment simulation, interference identification, interference simulation, and distributed quality of service evaluation of wireless networks.
Patent WO-2021217052-A1 (WO)
Inventor: BOLES T CHRISTIAN
IPC: C12Q1/68
Filed: 2021-04-23
Abstract: Embodiments of the present disclosure present methods, systems, and devices for extrachromosomal DNA extraction, and in some embodiments, isolation of DNA therefrom, and/or analysis of the extracted and/or isolated DNA, including, in some embodiments, ecDNA.
Patent WO-2021189062-A1 (WO)
Title: IDEAL DIAMAGNETIC RESPONSE OF A GRAPHENE-n-HEPTANE-PERMALLOY SYSTEM
Inventor: GULIAN ARMEN
IPC: H01L39/12
Filed: 2021-04-29
Abstract: Systems, methods, and apparatus for generating an ideal diamagnetic response are disclosed. A disclosed diamagnetic system includes a metal foil or a first substrate having at least one surface that is coated by a metallic layer (e.g., permalloy). The diamagnetic system also includes a second substrate having at least one surface that is coated by graphene. The first and second substrates are immersed in an alkane (e.g., n-heptane). The diamagnetic system produces a diamagnetic response at room temperature in an applied magnetic field when the alkane is added to surround the permalloy and graphene.
Patent WO-2021231350-A1 (WO)
Title: Compositions of polymeric microdevices and their use in cancer immunotherapy
Inventor: LANGER ROBERT S
IPC: A61K9/00
Filed: 2021-05-11
Abstract: Microparticulate compositions and methods for delivery and pulsatile release of one or more sting agonists and/or receptors have been developed. The compositions include polymeric microdevices formed from biodegradable and biocompatible polymers or co-polymers thereof including a shell and compartment(s) or discrete regions in the compartment(s) formed by an additive process such as micromolding, three-dimensional printing and lithography. The compositions include microdevices that release individual doses of incorporated STING agonist and/or receptors at defined times, for example, in pulses up to several months after administration with essentially no leakage between releases.
Patent WO-2021231905-A1 (WO)
Title: Ketamine treatment for amyotrophic lateral sclerosis
Inventor: BAROHN RICHARD
IPC: A61K31/428
Filed: 2021-05-14
Abstract: A method of treating amyotrophic lateral sclerosis (ALS) is provided to extend life expectancy in a subject. The method can include administering the ketamine to a subject having ALS such that the subject has an extended life expectancy compared to life expectancy of the subject prior to being administered the ketamine. The extended life expectancy is determined by the subject having a first progression rate of ALS prior to being administered ketamine and a second progression rate of ALS after being administered ketamine. The first progression rate is faster than the second progression rate such that the progression of ALS in the subject is slowed by the ketamine.
Patent WO-2021247762-A1 (WO)
Inventor: ADEMOYE TAORIDI A
IPC: H02P27/08
Filed: 2021-06-02
Abstract: Systems and methods for reducing current imbalance in a motor, where one embodiment comprises a system having an ESP installed in a well, an electric drive, and a power cable coupled between the drive and the ESP's motor. The electric drive generates output voltage waveforms (e.g., PWM waveforms) for multiple phases that may have different impedances. The system monitors the current of each phase at the output of the electric drive and determines a current imbalance between the phases. The drive generates voltage adjustments (e.g., duty cycle adjustments) corresponding to the respective phases, and applies each voltage adjustment to the corresponding voltage waveform. For example, the drive may determine an average of the phase currents, determine the difference between each phase current and the average, and multiply the result by a gain factor to generate the voltage for each phase. The process is iteratively performed to reduce the current imbalance.
Patent WO-2021252920-A1 (WO)
Title: Zbtb32 inhibitors and uses thereof
Inventor: ORLANDO ELENA
IPC: A61K35/17
Filed: 2021-06-11
Abstract: The disclosure provides compositions and methods for treating diseases such as cancer. The disclosure also relates to methods of making improved CART cell therapies, e.g., with reduced expression and/or a reduced biological activity of ZBTB32. The disclosure further provides ZBTB32 inhibitors, and methods of using the same alone or in combination with CART cell therapies.