baber/WOPTO huggingface dataset:
Patent AU-2020325115-A1 (AU)
Title: Pyridine derivatives as KIF18A inhibitors
Inventor: ALLEN JOHN GORDON
IPC: C07D498/08
Filed: 2020-08-03
Abstract: Amide compounds of formula (I): as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.
Patent AU-2020340441-A1 (AU)
Title: Hydrogels as oral delivery dosage forms, methods of making and using same
Inventor: GODFRIN PAUL DOUGLAS
IPC: C08F122/10
Filed: 2020-08-31
Abstract: Method of manufacturing, and use of cross-linked polymeric hydrogels as final dosage forms for the oral delivery of compounds with nutritional and/or therapeutic value, including but not limited to supplements, cell-based therapies, and active pharmaceutical ingredients.
Patent AU-2020341213-A1 (AU)
Title: Pharmaceutical composition comprising HDAC inhibitor and anti-PD1 antibody or anti PD-L1 antibody
Inventor: KIM YOUNG-DAE
IPC: A61K39/00
Filed: 2020-07-30
Abstract: The present invention relates to a method for killing cancer cells by using a combination of an HDAC inhibitor and an anti-PD1 antibody or an anti PD-L1 antibody. The present invention can have an effective influence on: extending the survival of animals with cancer, tumors, tumor-related disorders and neoplastic diseases; inhibiting the growth of proliferative cells associated with neoplasms; or neoplastic degeneration.
Patent AU-2020344901-A1 (AU)
Title: Annular barrier system
Inventor: VASQUES RICARDO REVES
IPC: E21B33/127
Filed: 2020-09-10
Abstract: The present invention relates to an annular barrier system for completing a well with a well tubular metal structure, comprising the well tubular metal structure and a first annular barrier and a second annular barrier, each annular barrier comprising a tubular metal part having a bore and mounted as part of the well tubular metal structure, an expandable metal sleeve surrounding the tubular metal part, each end of the expandable metal sleeve being connected with the tubular metal part, and an annular space between the expandable metal sleeve and the tubular metal part, each annular barrier being introduced and set in the well to abut a wall of the well, providing a confined space having a confined pressure Pc between the wall, part of the well tubular metal structure, the first annular barrier and the second annular barrier, so that the first annular barrier isolates the confined space from a first annulus having a first pressure, and the second annular barrier isolates the confined space from a second annulus having a second pressure, wherein the annular barrier system comprises a valve system having a first position in which the bore is in fluid communication with the annular space of at least one of the first annular barrier and the second annular barrier in order to expand the expandable metal sleeve, and a second position in which the bore is in fluid communication with the confined space in order to perform barrier verification by pressurising the confined space.
Patent AU-2020355343-A1 (AU)
Title: Polyheterocyclic modulators of sting (stimulator of interferon genes)
Inventor: FENSOME ANDREW
IPC: A61P35/00
Filed: 2020-09-22
Abstract: Compounds of the general formula (I), or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
Patent AU-2020375960-A1 (AU)
Title: Bridged cycloformylpyridine derivatives and uses thereof
Inventor: WANG QI
IPC: A61K31/444
Filed: 2020-10-21
Abstract: Provided are a compound of formula (I), or a pharmaceutically acceptable salt, solvate, active metabolite, polymorph, isotopic label, isomer or prodrug thereof, and a use thereof. The above-mentioned compound has a very strong inhibitory effect on the FGFR4 kinase activity and the proliferative activity of Hep 3B cells with high FGFR4 expression.
Patent AU-2020385538-A1 (AU)
Title: Dredging method and apparatus
Inventor: WARNER JEREMY DAVID
IPC: E02F3/92
Filed: 2020-10-27
Abstract: A method of dredging which comprises suspending dredging apparatus 200 from a vehicle 360. The sediment agitating apparatus comprising a chassis 210, and mounted on the chassis are an extractor, sediment agitating apparatus and respective pumps 220, 230. The dredging apparatus 200 is disposed above, but not in contact with a waterbed 340 to be dredged of sediment 350. The sediment 350 is agitated then extracted with the extractor. The dredging apparatus 200 is moved around the water and the extracted sediment 400 is deposited underwater and above the dredging apparatus 200, so that the sediment 400 is transported and deposited away from an area being dredged by the natural movement of the water. Apparatus and use of the apparatus are also described.
Patent AU-2020401372-A1 (AU)
Title: Accessories for a mandible advancement device
Inventor: KIM SUNG
IPC: A61B5/00
Filed: 2020-12-11
Abstract: Mandibular advancement devices (MAD) are disclosed comprising an upper splint, a lower splint, and at least one sensor, wherein the sensor measures a biological or biophysical aspect of a patient. Methods of using the devices are also disclosed.
Patent AU-2020475491-A1 (AU)
Title: Metal material for medical device, method of manufacturing metal material for medical device, and medical device
Inventor: HASEBE TERUMITSU
IPC: A61L31/12
Filed: 2020-11-09
Abstract: The present disclosure provides a metal material for a medical device, comprising a metal layer and a diamond-like carbon layer that is provided on the metal layer and that includes fluorine and silicon.
Patent WO-2021232093-A1 (WO)
Title: An apparatus and method for concentrating a fluid
Inventor: THOMSON CHRISTOPHER
IPC: C13B25/06
Filed: 2021-05-18
Abstract: A method of concentrating a process fluid, including a carrier fluid, including: (a) maintaining a process fluid at a predetermined temperature value/range; (b) evaporating the carrier fluid from the process fluid to produce a concentrated process fluid; (c) monitoring at least one process variable of steps (a) or (b) to detect fouling formed in either step (a) or (b); and (d) initiating a cleaning protocol if the process variable deviates from a predetermined value/range to reduce the fouling formed.
Patent WO-2022094659-A1 (WO)
Inventor: WIDANAGAMAGE DON LOCHANA SUBASEKARA
IPC: A47J31/06
Filed: 2021-11-04
Abstract: Une coupelle-filtre (100) contient du café moulu à l'intérieur d'un porte-filtre à des fins de fixation à une machine à expresso pour extraire une dose de café. La coupelle-filtre (100) comprend un corps (102) comprenant un plancher (104) avec une pluralité de perforations (106), une paroi latérale (108) s'étendant vers le haut à partir du plancher (104) jusqu'à un rebord (110) pour définir une cavité destinée à contenir le café moulu, et un aimant (114) fixé au corps (102) pour produire un champ magnétique.
Patent AU-2021200028-A1 (AU)
Title: Stacking power supply cabinet
Inventor: PAN FENG
IPC: H02B1/24
Filed: 2021-01-05
Abstract: A stacking power supply cabinet is provided. The stacking power supply cabinet includes 
a top assembly and at least one battery module. In the stacking power supply cabinet, in a 
case that the number of the battery module is more than one and the multiple battery modules 
5 are stacked sequentially from top to bottom, an electric connection path for power supply 
and/or storage is established among the stacked multiple battery modules, and the electric 
connection path is conducted via a power transmission line in the top assembly, and then the 
battery modules are charged. Thus, in the installation process of the power supply cabinet, the 
electric connection path for the power supply and/or storage among the multiple stacked 
0 battery modules is uncharged before the top assembly is installed, thereby reducing the risk of 
electric shock to the human body and improving the safety during the installation process of 
the stacking power supply cabinet.
3/9 
10 
31 
30 
33 
20F r 
Figure 3a
Patent AU-2021200980-A1 (AU)
Title: Lipid formulations for delivery of messenger rna
Inventor: DEROSA FRANK
IPC: A61K48/00
Filed: 2021-02-15
Abstract: WO 2015/061467 PCT/US2014/061793 
1/18 
HUMAN FACTORIX PROTEIN N SERUMOF FX MRT 
TREATED WLD TYPE MCE(24 hPOST-ADMISTRATIN) 
CD 
000 CD 
'3 12)20 MD1 
CATIONIC LtRD 
FIG. 1
Abstract 
The present invention provides, among other things, methods of delivering mRNA in vivo, 
including administering to a subject in need of delivery a composition comprising an mRNA 
encoding a protein, encapsulated within a liposome such that the administering of the 
composition results in the expression of the protein encoded by the mRNA in vivo, wherein 
the liposome comprises a cationic lipid of formula I-c: or a pharmaceutically acceptable salt 
thereof. See Fig. I-c
Patent AU-2021202371-A1 (AU)
Title: Recombinant cell surface capture proteins
Inventor: DESHPANDE DIPALI
IPC: C12N15/10
Filed: 2021-04-19
Abstract: Recombinant cell surface capture proteins and detection molecules that are useful for 
isolating and detecting cells that produce a secreted heterodimeric protein of interest (POI) 
that has an immunoglobulin CH3 domain and/or substituted CH3 domain are provided.  
Recombinant cell surface capture proteins and detection molecules that isolate and detect 
bispecific antibodies are also provided. The invention also provides recombinant antigen
binding proteins that are capable of recognizing and binding to proteins of interest that 
contain a CH3 domain and/or a modified CH3 domain, such as a CH3 domain with or without 
amino acid substitutions at H95 and Y96 (IMGT).
Patent AU-2021203510-A1 (AU)
Title: Money handling apparatus and money handling method
Inventor: KOBAYASHI SATORU
IPC: G07D11/18
Filed: 2021-05-28
Abstract: A money handling apparatus includes a receptacle that 
receives money; a plurality of storage units; a collection unit; 
and control circuitry. Each storage unit stores the money and 
feeds out the stored money. The collection unit stores money in 
a container, the container being detachably mounted to the 
collection unit. The control circuitry is configured to control 
storage of collection target money, which is to be collected and 
removed from the money handling apparatus, in the container and 
at least one storage unit of the plurality of storage units.
1/21 
FIG.1A 
101 
O OPERATION UNIT 100 110 
30 (INPUT UNIT)(( 
DEPOSITING 
UNIT UNT++ MEMORY 
40UNI 
DISPENSING RECOGNITION 
UNIT 80( UNIT IO 90 
1 5 1- - - - - - - - - -- -
140 
5 COLLECTION STORAGE STORAGE CONTAINER UNIT UNIT 
COLLECTION 
UNIT 141 V130a 130b 
FIG.1B 
15 140 130a 130b AT START OF BUSINESS HOURS 
BANKNOTES FOR CHANGE 
(RECYCLE BANKNOTES) 
PROCEEDS FROM SALES 
(COLLECTION TARGET 
BANKNOTES) 
COLLECTION STORAGE STORAGE 
CONTAINER UNIT UNIT 
FIG.1C 
140 130a 130b AFTER BUSINESS HOURS 
(AFTER COLLECTION PROCESS) 
BANKNOTES FOR CHANGE 
(RECYCLE BANKNOTES) 
PROCEEDS FROM SALES 
-.-..-..-..-. (COLLECTION TARGET 
BANKNOTES) 
COLLECTION STORAGE STORAGE 
CONTAINER UNIT UNIT
Patent AU-2021203901-A1 (AU)
Title: Biochips to diagnose hemoglobin disorders and monitor blood cells
Inventor: GURKAN UMUT A
IPC: G01N33/483
Filed: 2021-06-11
Abstract: A biochip compatible with very small blood sample volumes is used for detecting hemoglobin disorders 
and monitoring disorders associated with aberrant blood cell deformability and adhesion, including 
disease severity, upcoming pain crisis, treatment response, and treatment effectiveness in a clinically 
meaningful way.
Patent AU-2021211236-A1 (AU)
Title: Cellular uptake
Inventor: NEW ROGER R C
IPC: A61P43/00
Filed: 2021-01-22
Abstract: The present invention provides a bile acid or a pharmaceutically acceptable salt thereof, for use in a method of treatment of the human or animal body, which method comprises administering a therapeutic compound to the human or animal body, wherein: a. said bile acid is chenodeoxycholic acid or deoxycholic acid, and b. optionally, said bile salt is employed in conjunction with EDTA, c. in said method the bile acid or salt thereof, and EDTA, are used to enable or enhance intracellular uptake of the therapeutic compound.
Patent AU-2021221606-A1 (AU)
Title: Wear element for a slurry pump
Inventor: TUOMISALO AKI
IPC: F04D29/02
Filed: 2021-08-25
Abstract: The disclosure relates to a wear element (23) for a slurry pump 
arrangeable in a pump housing, wherein at least a portion of the wear 
element (23) produces a magnetic field for attracting magnetic particles in a 
5 slurry processed by the slurry pump. The disclosure further relates to a slurry 
pump (1) comprising a pump housing (2) and a wear element (23) arranged 
within the pump housing (2), wherein at least a portion of the wear element 
(23) produces a magnetic field for attracting magnetic particles present in a 
slurry processed by the slurry pump (1). The disclosure also relates to a 
10 method for producing a protective wear layer in a slurry pump comprising the 
steps of arranging a wear element in a housing of the slurry pump, wherein at 
least a portion of the wear element produces a magnetic field; and pumping a 
slurry comprising magnetic particles through the slurry pump, whereby 
magnetic particles of the slurry are attracted by the magnetic field, thereby 
15 creating the protective wear layer on the wear element.  
Figure elected for publication purposes: Fig 1.
1/3 
16 17 6 9 6 6 
3 
8 
23 
2 10 7 
4 
5 
6 Fig. 1 
15' 
fr men fir 
r it i r en *ta dem lika 
t Isngs liner.  
4 
5 
23 
13 14 16 9\, 18 
•i.
Patent AU-2021249347-A1 (AU)
Title: Composition for improving friendliness and/or empathetic capacity
Inventor: TOKUDA HISANORI
IPC: A61K31/202
Filed: 2021-03-26
Abstract: The purpose of the present invention is to provide a composition for improving friendliness and/or empathetic capacity, and a method for improving friendliness and/or empathetic capacity, that make it possible to improve friendliness and/or empathetic capacity. The present invention pertains to a composition for improving friendliness and/or empathetic capacity, the composition containing one or more selected from the group consisting of C20 or higher long-chain highly unsaturated fatty acids and derivatives thereof.
Patent AU-2021251382-A1 (AU)
Title: Pro-adrenomedullin for prognosing disease progression in severe acute respiratory syndrome (SARS)
Inventor: EBMEYER STEFAN
IPC: G01N33/569
Filed: 2021-04-06
Abstract: The invention relates to a method for prognosing disease progression in a patient that has or is at risk of developing a severe acute respiratory syndrome (SARS), wherein the method comprises determining a level of pro-adrenomedullin (proADM) or fragment(s) thereof in a sample from the patient, wherein said level indicates the severity of SARS progression. The method is in some embodiments configured for use when a patient exhibits symptoms of a severe acute respiratory syndrome (SARS), a patient exhibits symptoms of infection with a SARS-virus, the patient is infected with a SARS-virus, such as a SARS-coronavirus, such as SARS-CoV2.
Patent AU-2021254528-A1 (AU)
Title: Tuning of a kinematic relationship between members
Inventor: DIEHL ANDREW KARL
IPC: B60L7/28
Filed: 2021-10-19
Abstract: Described herein is a device comprising members in a kinematic relationship. The kinematic 
relationship is at least partially governed by at least one magnetic flux interaction that, in effect, may 
provide a tuneable resistance to movement, changing the rate of relative movement between the 
members. In one embodiment, the device comprises a first member in a kinematic relationship with 
at least one further member to form a system. The system moves within a limited range of motion 
and the system interacts when an external energising force is imposed on the system causing the 
members to respond due to their kinematic and dynamic characteristics and thereby creating relative 
motion between the members. The trigger member is coupled to the at least the first member and 
moves in response to a pre-determined system movement. When the trigger member moves, the 
trigger member imposes a braking action on the system or a member or members thereof. The speed 
and/or intensity of the braking action imposed by the trigger member on the system or a member or 
members thereof is controlled by the trigger member rate of movement. This rate of movement is in 
turn governed by a magnetic flux interaction between the trigger member and the at least one first 
member causing formation of a magnetically induced eddy current force between the parts.  
18
Patent AU-2021261910-A1 (AU)
Title: Human immunodeficiency virus neutralizing antibodies
Inventor: BALAKRISHNAN MINI
IPC: C07K16/10
Filed: 2021-11-04
Abstract: The present invention provides novel anti-HIV antibodies with improved therapeutic properties, 
related pharmaceutical compositions, and methods of use thereof.  
2
Patent AU-2021263420-A1 (AU)
Title: Nested model simulations to generate subsurface representations
Inventor: HARRIS ASHLEY D
IPC: G01V1/28
Filed: 2021-04-29
Abstract: Process-based numerical forward stratigraphic models of different spatiotemporal scales may be nested to address subsurface characterization at different scales. Subsurface representations may be generated using an iterative loop in which subsurface representations are generated using different-scale subsurface models, compared to scale-appropriate data, and used to define boundary conditions/inputs for subsequently run subsurface models. Results from the subsurface models may be compared to one or more standards for quality control and/or for subsurface representation selection. A series of comprehensive subsurface representations may be generated, with the subsurface representations being constrained by different scales of information and physical plausible scenarios.
Patent AU-2021267168-A1 (AU)
Title: Bifunctional degraders of hematopoietic progenitor kinase and therapeutic uses thereof
Inventor: SHUNATONA HUNTER P
IPC: A61K31/4188
Filed: 2021-05-05
Abstract: The present disclosure provides bifunctional compounds as HPK1 degraders via ubiquitin proteosome pathway, and method for treating diseases modulated by HPK1.
Patent AU-2021271467-A1 (AU)
Title: Tunnel excavation device
Inventor: SUWANO MASAHIRO
IPC: E21D9/06
Filed: 2021-04-22
Abstract: A tunnel excavation apparatus (1) comprises a body (10), a frame (15), and a work stand (16). The body (10) has a front barrel part (11) and a rear barrel part (12). The front barrel part (11) has a cutter head (21) provided with a plurality of disc cutters (83). The rear barrel part (12) includes a gripper part (90) for obtaining reaction force during performance of excavation, and is positioned behind the front barrel part (11). The frame (15) is positioned behind the body (10) and is continuous with the body (10). The work stand (16) is positioned on the upper side of the frame (15) and is capable of rotating relative to the frame (15).
Patent AU-2021277703-A1 (AU)
Title: Input device and user interface interactions
Inventor: VAN OS MARCEL
IPC: G06F3/0488
Filed: 2021-12-02
Abstract: In some embodiments, a device displays functionality information in response to receiving an 
indication of a first input for which a contact meets functionality display criteria. In some 
embodiments, a device generates a user interface that includes a navigation bar including 
images from different positions in a respective content item, and a representation of an 
adjacent content item. In some embodiments, a device moves a selection-indicator in a user 
interface by a predefined amount in response to receiving an indication of a first input that 
meets unitary movement criteria. In some embodiments, a device interprets movement of a 
contact of an input based at least in part on a grip of a user. In some embodiments, a device 
displays a plurality of character selection options when a text entry field is not tolerant of 
character ambiguity and a first input corresponds to a plurality of candidate characters.
Patent AU-2021294317-A1 (AU)
Title: Donor T-cells with kill switch
Inventor: CHEN CHAO-GUANG
IPC: C12N9/22
Filed: 2021-06-25
Abstract: The disclosed methods are generally directed to preventing, treating, suppressing, controlling or otherwise mitigating side effects of T-cell therapy, the T-cell therapy designed to accelerate immune reconstitution, induce a graft-versus-malignancy effect, and/or target tumor cells. In some embodiments, the present disclosure provides delivery vehicles including components adapted to knockout HPRT. In some embodiments, the delivery vehicles include a gRNA molecule and an endonuclease, e.g. a Cas protein. In some embodiments, the gRNA molecules target locations within Exons 2, 3, or 8 of the HPRT 1 gene.
Patent AU-2021337195-A1 (AU)
Title: Novel compounds
Inventor: MILLER NEIL
IPC: C07D263/54
Filed: 2021-09-01
Abstract: The invention relates to compounds of formula (I): and related aspects.
Patent AU-2021345024-A1 (AU)
Title: Segmented backup ring, system and method
Inventor: DENG GUIJUN
IPC: E21B33/12
Filed: 2021-09-14
Abstract: A segmented backup ring including a plurality of individual segments each having curved surfaces that define an arcuate portion of the ring, each segment including a body section having the arcuate profile and defining a receptacle therein having a circumferential dimension, a projection section having a head portion and a neck portion and extending from the body section in a circumferential direction of the ring, the projection section being receivable and retainable in the receptacle of an adjacent segment body section, and the head portion having a dimension in line with the circumferential direction of the ring that is shorter than the circumferential dimension of the receptacle.
Patent AU-2021348225-A1 (AU)
Title: Compound for the prevention or treatment of myasthenia gravis
Inventor: SMRZKA OSKAR
IPC: C07K17/06
Filed: 2021-09-23
Abstract: The present invention provides a compound for the sequestration of anti human muscle nicotinic acetylcholine receptor (AChR) autoantibodies, which are involved in the pathogenesis of MG. The compound comprises an inert biopolymer scaffold and at least two peptides with a sequence length of 6-13 amino acids, wherein each of the peptides independently comprises an amino-acid sequence comprising an AChR main immunogenic region (MIR) epitope or mimotope. Also provided are pharmaceutical compositions comprising the compound, as well as a method of sequestering one or more antibodies present in an individual.
Patent AU-2021448382-A1 (AU)
Title: Self activating seal assembly backup
Inventor: ELDHO SHANU THOTTUNGAL
IPC: E21B33/127
Filed: 2021-05-29
Abstract: Provided is a seal assembly. The seal assembly, in one aspect, includes a first member, the first member formed of a first material, and a second member overlapping with the first member, the second member formed of a second material, the first and second members defining an overlapping fluid leakage path. The seal assembly according to this aspect further includes a primary seal positioned in the overlapping fluid leakage path, the primary seal configured to prevent fluid from passing from a first side of the overlapping fluid leakage path to a second side of the overlapping fluid leakage path. The seal assembly according to this aspect additionally includes an expandable metal backup seal positioned in the second side of the overlapping fluid leakage path, the expandable metal backup seal including a metal configured to expand in response to hydrolysis.