Patent SG-11201810952P-A (SG)
Title: Lantibiotic variants and uses thereof
Inventor: HANDFIELD MARTIN
IPC: A61K8/64
Filed: 2017-07-14
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1#1110111101110101011111 vu 1101 0 011111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/013967 Al 18 January 2018 (18.01.2018) W I P0 I P C T (51) International Patent Classification: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, A61K 8/64 (2006.01) C07K 14/315 (2006.01) KM, ML, MR, NE, SN, TD, TG). A61Q 11/00 (2006.01) Cl 2N 9/04 (2006.01) (21) International Application Number: Published: PCT/US2017/042206 — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) (22) International Filing Date: 14 July 2017 (14.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/362,788 15 July 2016 (15.07.2016) US 62/362,809 15 July 2016 (15.07.2016) US 62/420,328 10 November 2016 (10.11.2016) US (71) Applicant: INTREXON CORPORATION [US/US]; 1750 Kraft Drive, Suite 1400, Blacksburg, VA 24060 (US). (72) Inventors: HANDFIELD, Martin; 9222 SW 41st Lane, Gainesville, FL 32608 (US). KERS, Johan, Anthony; 9 Avon Road, Welleskey, MA 02482 (US). MULEY, Sheela; 775 Longfellow Drive, Fremont, CA 94539 (US). MAYO, Melissa; 41 Rock Harbor Lane, Foster City, CA 94404 (US). COLBECK, Jeffrey; 1001 Continentals Way, Apt. 211, Belmont, CA 94002 (US). SHARP, Robert, Eryl; 2817 Alhambra Drive, Belmont, CA 94002 (US). FOS- MOE, Albert, G., II; 7815 SW 43rd Place, Gainesville, FL 32608 (US). DEFUSCO, Anthony, W.; 2525 NW 144th Way, Newberry, FL 32669 (US). (74) Agent: WOODHOUSE, Scott, M.; Medler Ferro Wood- house & Mills PLLC, 8201 Greensboro Drive, Suite 1060, McLean, VA 22102 (US). Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = (81) (84) Designated States (unless otherwise indicated, for every 1-1 IN SD 01 en 1-1 kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 0 --.... 00 1-1 (54) 0 Title: LANTIBIOTIC VARIANTS AND USES THEREOF ei (57) : The disclosure relates to lantibiotic structural variants that have improved antimicrobial properties when compared to 0 wild -type lantibiotics, and uses thereof. Embodiments include non- naturally occurring lantibiotics.