baber/WOPTO huggingface dataset:
Patent DE-69628333-D1 (DE)
Inventor: VERNIER MICHEL
IPC: A61P25/00
Filed: 1996-11-14
Granted: 2003-06-26
Abstract: In accordance with the present invention, a novel class of substituted aryl compounds (containing ether, ester, amide, ketone or thioether substitution) that promote the release of ligands involved in neurotransmission have been discovered. In a particular aspect, compounds of the present invention are capable of modulating acetylcholine receptors. The compounds of the present invention are capable of displacing one or more acetylcholine receptor ligands, e.g., <3>H-nicotine, from mammalian neuronal membrane binding sites. Invention compounds may act as agonists, partial agonists, antagonists or allosteric modulators of acetylcholine receptors. Therapeutic indications for compounds with activity at acetylcholine receptors include diseases of the central nervous system such as Alzheimer's disease and other diseases involving memory loss and/or dementia (including AIDS dementia); cognitive dysfunction (including disorders of attention, focus and concentration), disorders of extrapyramidal motor function such as Parkinson's disease, progressive supramuscular palsy, Huntington's disease, Gilles de la Tourette syndrome and tardive dyskinesia; mood and emotional disorders such as depression, anxiety and psychosis; substance abuse including withdrawal symptoms and substitution therapy; neurocrine disorders and dysregulation of food intake, including bulimia and anorexia; disorders or nociception and control of pain; autonomic disorders including dysfunction of gastrointestinal motility and function such as inflammatory bowel disease, irritable bowel syndrome, diarrhea, constipation, gastric acid secretion and ulcers; pheochromocytoma, cardiovascular dysfunction including hypertension and cardiac arrhythmias, as well as co-medication uses in surgical applications.
Patent DE-69630514-D1 (DE)
Inventor: LEVY ROBERT J
IPC: A61K9/16
Filed: 1996-01-04
Granted: 2003-12-04
Abstract: Biodegradable controlled release nanoparticles as sustained release bioactive agent delivery vehicles include surface modifying agents to target binding of the nanoparticles to tissues or cells of living systems, to enhance nanoparticle sustained release properties, and to protect nanoparticle-incorporated bioactive agents. Unique methods of making small (10 nm to 15 nm, and preferably 20 nm to 35 nm) nanoparticles having a narrow size distribution which can be surface-modified after the nanoparticles are formed is described. Techniques for modifying the surface include a lyophilization technique to produce a physically adsorbed coating and epoxy-derivatization to functionalize the surface of the nanoparticles to covalently bind molecules of interest. The manoparticles may also comprise hydroxy-terminated or epoxide-terminated and/or activated multiblock copolymers, having hydrophobic segments which may be polycaprolactone and hydrophilic segments. The nanoparticles are useful for local intravascular administration of smooth muscle inhibitors and antithrombogenic agents as part of interventional cardiac or vascular catheterization such as a balloon angioplasty procedure; direct application to tissues and/or cells for gene therapy, such as the delivery of osteotropic genes or gene segments into bone progenitor cells; or oral administration in an enteric capsule for delivery of protein/peptide based vaccines.
Patent DE-69630787-D1 (DE)
Inventor: COHEN R
IPC: A61P3/08
Filed: 1996-07-02
Granted: 2003-12-24
Abstract: Metabolizable lipid emulsions, such as Intralipid and Lipofundin, are excellent vehicles for peptide therapy of autoimmune diseases and of other TH1 T cell mediated diseases or conditions, as it promotes a TH1 to TH2 cytokine shift. Such emulsions may be used in conjunction with an antigen recognized by inflammatory T cells associated with the pathogenesis of a T cell mediated disease or condition for the therapeutic treatment of such a condition.
Patent DE-69635195-D1 (DE)
Inventor: MULIER M
IPC: A61B18/14
Filed: 1996-10-02
Granted: 2005-10-20
Abstract: The present invention is related to a medical device, preferably for use in electrocauterization. The device has a non-conductive handle and a rigid, elongated electrode extending from the distal end of the handle and has a porous metal element defining a distal end of the electrode. The electrode further defines a lumen in fluid communication with the porous element and the porous metal element is adapted to distribute fluid axially outward from the lumen at the distal end of the lumen.
Patent DE-69637425-D1 (DE)
Inventor: CRIDER GRANT W
IPC: E06B9/13
Filed: 1996-11-08
Granted: 2008-03-20
Abstract: A roll-up closure utilising a flexible cover (18). The cover (18) is at least as wide as the portal (11) to be covered and is typically longer than the portal (11). Each lateral margin (21, 22) of the cover (18) has a strip of fastener material (27) affixed thereto, and a complimentary strip (26) is affixed to the lateral margins (12, 13) of the structure defining the portal (11). A first end (19) of the cover (18) is affixed across a first margin (17) of the portal (11). The opposite end (23) is upturned and connected to a take-up roller (31) mounted above the first margin (17) of the portal (11). A transverse rod (34) is supported within a pocket formed by the upturned end (23). Activation of the roller (31) lengthens or shortens the effective length of the cover (18) and the mating fasteners (26, 27) are positioned to seal and unseal the cover (18) to the lateral margins (12, 13) of the portal (11). Additional elements can be included to promote formation of an adequate seal. <IMAGE>
Patent DE-69701310-D1 (DE)
Inventor: BOUVIER JACKY
IPC: H04B5/00
Filed: 1997-04-02
Granted: 2000-03-23
Abstract: PCT No. PCT/FR97/00584 Sec. 371 Date Feb. 26, 1999 Sec. 102(e) Date Feb. 26, 1999 PCT Filed Apr. 2, 1997 PCT Pub. No. WO97/38391 PCT Pub. Date Oct. 16, 1997A memory card, capable of remotely exchanging information with a terminal by modulating a magnetic field generated by said terminal, includes a voltage limiter (LMT) with an input terminal (BE) for receiving, during the transmission of information between the terminal and the card, an amplitude modulated voltage (VNR) with a time-varying average voltage level (NM). A primary transistor (TZ1) is connected between the input terminal and ground. Diodes (D1. . . DN) are series connected between the input terminal (BE) and ground and between the input terminal (BE) and the gate of the primary transistor (TZ1), wherein the threshold voltages of the diodes and primary transistor define a limit value for the input voltage. A capacitor (C) is connected between the primary transistor gate and ground. A resistive array (RD, TR) is connected between the capacitor and ground, and forms, with the capacitor, a resistive/capacitive array with a time constant selected so as to be comprised between the time variation period of the average voltage level and the amplitude modulation period.
Patent DE-69708330-D1 (DE)
Inventor: BUDD MICHAEL
IPC: C03C10/00
Filed: 1997-07-02
Granted: 2001-12-20
Abstract: The present invention relates to glass ceramic material and its use as means for joining different types of material and as support. Said glass ceramic material comprising, on a weight percent basis, 10-35% MgO, 10-55% BaO and 25-50% SiO2 and is formed by the following steps: a) melting of glass raw material at a temperature in excess of 1450 ° C. and that the thereby formed melt is cooled rapidly to a temperature below 900° C. and thereafter to ambient temperature to form a precursor glass, b) milling of the precursor glass into a sinterable glass powder with an average particle size in the range of 1 micron to 100 microns, c) forming of the glass powder into a green body of suitable shape, with or without organic processing aids, and subjecting said green body to a thermal treatment comprising a heating stage of average heating rate not exceeding 100 ° C./minute between the temperatures of 750 ° C. and 900 ° C.
Patent DE-69713338-D1 (DE)
Inventor: ARDAUD PIERRE
IPC: C08L75/04
Filed: 1997-07-30
Granted: 2002-07-18
Abstract: A composition comprises, for successive or simultaneous addition, at least partially masked isocyanate with a Tg of at least = 20 degrees C, advantageously at least 40 degrees C and discharge rate (vis a vis masking agent) of at least 5% at 120 degrees C; and polyol with Tg of at least 40 degrees C, advantageously at least 50 degrees C, hydroxyl index at least 10 mgg<-1>, advantageously at least 15 mgg<-1>, and molecular mass at least 1000, advantageously 2000 gmole<-1>. Also claimed are use of the compound for providing coatings, notably paint; and coating obtained therefrom.
Patent DE-69714695-D1 (DE)
Inventor: BUTTNER GARY J
IPC: G06V10/40
Filed: 1997-11-25
Granted: 2002-09-19
Abstract: A method of determining the existence of a target light source comprising progressively receiving successive pixel intensity values row by row and column by column of a scanned array of a light detector, comparing each pixel intensity value as it is received with upper and lower thresholds, declaring successive rows of pixels as dark, bright, edge or null depending on whether each row of the intensity values above, between and below the thresholds meets predetermined criteria, declaring a light source as detected in the event an array of pixels exceeding the lower threshold are completely surrounded by pixels which are of lower intensity than the lower threshold, and storing a signal indicating detection of a light source in a memory with a location identifying an address of the array in which the light source was declared as detected. <IMAGE>
Patent DE-69733660-D1 (DE)
Inventor: SETHURAM M
IPC: C01B13/28
Filed: 1997-11-04
Granted: 2005-08-04
Abstract: The present invention relates to the production of ultrafine powders using a microwave plasma apparatus and chemical synthesis technique. Microwaves generated by a magnetron (1) are passed through waveguides (2) before they arrive at the head of a plasmatron (3). These high energy microwaves ionize a plasma gas, thus releasing large amounts of energy. The energy thus released is utilized to initiate and sustain chemical reactions between the desired elements being pumped in a spiral pattern into the plasmatron (3). The reaction products are quenched rapidly in a reactor column (4) into ultrafine powders.
Patent DE-69734101-D1 (DE)
Inventor: GARCIA AMIGOT JUAN FELIX
IPC: B60L5/19
Filed: 1997-07-01
Granted: 2005-10-06
Abstract: Electrical energy intake assembly for swivel trains, which comprises a pantograph (4) assembled on a platform (1), said platform being capable of movement in transversal direction in relation to the vehicle (3) and is connected to the bogie (15-16) of said vehicle thru one or more flexible controls (12), comprised of a fixed sheath and a mobile web, which is connected to the platform (1) thru a reducing/amplifying mechanism (13) and to the bogie thru tie down devices (14) which transmit to the control web (12) only the swivel motions of the bogie. <IMAGE>
Patent DE-69739253-D1 (DE)
Inventor: KEDAR ELIEZER
IPC: A61K38/00
Filed: 1997-06-24
Granted: 2009-03-26
Abstract: Subunit influenza vaccines containing an influenza H/N antigen and a cytokine immunopotentiator, where at least one and preferably both are encapsulated in liposomes, are described. The vaccines stimulate a strong humoral and CTL response. Also described are methods of immunization using such vaccines.
Patent DE-69803139-D1 (DE)
Inventor: SATO HIROYUKI
IPC: G11B33/04
Filed: 1998-04-30
Granted: 2002-02-21
Abstract: It is the issue to provide a compact disc storage case that resolves the problems with conventional technologies and which makes it possible to reduce forming costs and improve the efficiency of forming work. Being that the compact disc storage case that is this invention (30) is a flat, parallelepipedic compact disc storage case having a lid (23) moveably hinged at one end of said lid's (23) sides (15, 16) to one end of the sides (4, 5) of the disc storage compartment (22), and that said storage compartment (22) has a rising (24) protruding from the bottom panel (3) between the ends of said sides (4, 5), the label is secured to the outer face of said rising (24), so that relatively large undercuts such as conventional pockets are eliminated, the rising (24) does not form undercuts, and the storage compartment (22), after forming, is easily discharged from the die cavity. <IMAGE>
Patent DE-69809899-D1 (DE)
Inventor: SANJURJO ANGEL
IPC: C23C16/442
Filed: 1998-04-28
Granted: 2003-01-16
Abstract: A fluidized-bed reactor for the chemical vapor deposition of a coating on a substrate surface is described. The reactor enables high rates of deposition and a highly homogeneous coating by modifying the boundary layer formed between the gasified reactive gas stream and the substrate. The boundary layer is minimized by the presence of an exhaust outlet placed in close proximity to the center of the surface of the substrate and/or the presence of a gas inlet capable of injecting a tangential stream of gas which results in a swirling radial flow of reactive gas. Methods of forming a metal coating on a surface of a substrate using the reactor are provided as well.
Patent DE-69810084-D1 (DE)
Inventor: BROWN MARTIN-ZENECA HUDDERSFIE
IPC: C07D213/64
Filed: 1998-02-09
Granted: 2003-01-23
Abstract: 2-Hydroxy-6-trifluoromethylpyridine is prepared by reacting 2-chloro-6-trifluoromethylpyridine with an aqueous alkali metal hydroxide in a sealed vessel at a temperature of at least 140 DEG  C. under autogenous pressure.
Patent DE-69816963-D1 (DE)
Inventor: UENO RYUZO
IPC: C09B62/02
Filed: 1998-08-25
Granted: 2003-09-11
Abstract: The present invention provides novel water-soluble azo compounds derived from 2-hydroxynaphthalene-3,6-dicarboxylic acid or derivatives thereof and diazonium salts having sulfo group(s). These compounds are useful as raw materials for dyes having excellent dyeing properties and fastness.
Patent DE-69823940-D1 (DE)
Inventor: RADIGON ERIC
IPC: C09J123/08
Filed: 1998-09-11
Granted: 2004-06-24
Abstract: Pressure sensitive adhesives based on a mixture of polystyrene-polybutadiene (SBS) or polystyrene-polyisoprene (SIS) block copolymers and ethylene-alkyl (meth)acrylate copolymers can be applied from a hot melt and formulated to give a specified type of adhesive rupture between substrate and second surface. The adhesive comprises (I) a mixture of a block copolymer (A) with polystyrene blocks and blocks of polybutadiene or polyisoprene which are optionally hydrogenated, and a copolymer (B)(ISJ1) of ethylene and an alkyl (meth)acrylate; (II) at least one tackifying resin and (III) optionally a plasticizer. The composition preferably contains 50 - 180 (100 - 150) parts wt. of the tackifying resin (II) and 10-30 parts wt. plasticizer (III) per 100 parts wt. of the mixture (I).
Patent DE-69835242-D1 (DE)
Inventor: AZAR ZION
IPC: A61B18/18
Filed: 1998-12-14
Granted: 2006-08-24
Abstract: Apparatus for removing hairs (27) form a region of skin, the apparatus including: a housing (12) having an opening therein, the housing (12) forming a cavity enclosing a volume of air when the opening is placed in contact with the region of skin; a switchable heat source (14) disposed within the housing(12) that rapidly heats the volume of air to a temperature sufficient to destroy the hair (27) by conduction of heat along the length of the hair (27) to a follicle thereof, and a power source (16) that controllably energizes the heat source (14).
Patent DE-69840699-D1 (DE)
Inventor: BALLINGER MARCUS D
IPC: C12P21/02
Filed: 1998-02-10
Granted: 2009-05-14
Abstract: The present invention provides heregulin variants that are capable of binding an ErbB receptor. Included in the invention are variants of human heregulins, and, in particular, variants of human heregulin-beta1 having enhanced affinity for the ErbB-3 and ErbB-4 receptors. These variants include at least one amino acid substitution and can include further modifications. The invention also provides nucleic acid molecules encoding heregulin variants and related vectors, host cells, pharmaceutical compositions, and methods.
Patent DE-69840774-D1 (DE)
Inventor: RAY CHARLES DEAN
IPC: A61B17/70
Filed: 1998-02-06
Granted: 2009-06-04
Abstract: An apparatus for facilitating the fusion of adjacent bone structures includes implant members configured for insertion within a space defined between adjacent bone structures. The device provides a series of resilient supporting arches which serve to act as spacers between two adjacent bone structures. The implant members include a longitudinal portion separated by a plurality of ribs and a lateral chamber used to accommodate various sized spacer rods.
Patent DE-69900866-D1 (DE)
Inventor: DESJOYAUX LOUIS
IPC: E04H4/12
Filed: 1999-03-18
Granted: 2002-03-21
Abstract: A filtration unit for a swimming pool having a basin. The unit includes a filtration compartment that communicates with the water in the basin and is secured to a side wall of the pool. The filtration compartment is spaced apart from a pumping compartment by a passageway. The passageway possesses a water-tight wall and sealed connections for the pump's suction and delivery pipes. The two compartments are closed by a lid which has perforations over a third duct compartment that communicates with the pumping compartment whereby ambient air can freely enter the duct. In one application of the invention the unit can be straddle mounted upon the wall of an existing pool. In another application the unit can be integrated into a sidewall of a pool as the pool is being erected.
Patent DE-69903428-D1 (DE)
Inventor: LAGARES COROMINAS NARCISO
IPC: G01F11/04
Filed: 1999-06-03
Granted: 2002-11-14
Abstract: Volumetric dosing apparatus for pasty material comprising a dosing chamber (4) which is internally provided with a piston (5) displaceable freely by means of pasty material (M) introduced through a first extremity (4a) of said chamber (4) from a first position (5A) to a second position (5B), the piston being the actuated by means of a pressure fluid (F) introduced through a second extremity (4b) to return to said first position (5A), thereby displacing a volume of material (M) delimited between (5A) and (5B), said material volume being ejected through the extremity (4a) which is associated by sealed closing means (3, 17) to an opening (6a) of a housing (6) wherein is housed a valve body (7) with means (19) to move the body inside the housing (6) thereby communicating an inlet (1) with said chamber (4), and alternatingly, communicating said chamber (4) with an outlet conduit (2) having emptying piston (8). <IMAGE>
Patent DE-69904170-D1 (DE)
Inventor: GALLAGHER E
IPC: B29C65/00
Filed: 1999-06-08
Granted: 2003-01-09
Abstract: A prefabricated multi-layered flexible product which can be used as a liner for an outer shell or as a stand-alone product. A substrate fabric material is placed in parallel with a synthetic film membrane to form a two ply laminate with excess membrane at an edge thereof. A pair of the laminates are overlaid with the substrate fabrics opposing each other with the fabric edges aligned, and a thermoplastic film is strategically placed in between the layers to enhance bonding between the fabric layers and the excess membranes. The laminate(s) and/or separate sheets of above materials are assembled by using a radio frequency welding process and then out into two or three dimensional forms, which in their bonded state form either a prefabricated component liner or a prefabricated stand-alone product. The form may be a glove, sock, shirt, boot/shoe, hat, jacket, pant, etc.
Patent DE-69906780-D1 (DE)
Inventor: CLARKE KEVIN WILLIAM JOSEPH
IPC: B65D25/02
Filed: 1999-10-07
Granted: 2003-05-15
Abstract: A container comprising an inner thermoformed vessel (1) and an outer thermoformed vessel (2), arranged the one within the other. The side walls (9) of the outer forming (2) surround the side walls (10) of the inner forming (1). The outer side walls has inwardly projecting ribs (11), which abut the inner side walls (10) to maintain an air gap (12) between the formings, with the formings being centered with respect to each other. The air gap is present between the bases (13, 14) of the inner and outer formings, with the outer forming being provided with ribs in its base also. In use food in the container can be heated in a micro-wave oven until hot. The air gap separates a handler's fingers from direct thermal contact with the hot food so that the container remains comfortable to handle.
Patent DE-69908317-D1 (DE)
Inventor: BERTRAM TEOFILIUS
IPC: B65B29/10
Filed: 1999-03-12
Granted: 2003-07-03
Abstract: A foam-in-bag packaging system and method of forming the same is provided in which a bag of flexible plastic film material includes superposed panels joined around their peripheral edges to define an enclosed space which is vented to the outside of the bag by venting perforations in the panels, a packet or pouch of barrier material capable of maintaining foam precursor components in a stable, unreacted state for an extended time period is positioned in the enclosed space in the bag adjacent one end thereof and secured from movement therefrom, the packet has first and second compartments therein separated by a first frangible seal extending across the packet and first and second foam precursor components contained respectively in the first and second compartments, the packet has a second frangible seal between one of the compartments and the enclosed space in the bag, the bag being folded along spaced transverse fold lines into a relatively compact form and being folded along a fold line coincident with the first frangible seal to form a mechanical barrier between the first and second compartments of the packet, and a detachable label holding the bag in its folded, compact form.
Patent DE-69910799-D1 (DE)
Inventor: BLECKMAN MICHAEL
IPC: C07D409/12
Filed: 1999-09-03
Granted: 2003-10-02
Abstract: Compounds of the formula:(where R1, R2 and R3 are defined in the specification) are inhibitors of AICARFT. These compounds, as well as their pharmaceutically acceptable salts, solvents, prodrugs, and pharmaceutically active metabolites, are useful in pharmaceutical compositions for treating diseases such as cancer.
Patent DE-69914073-D1 (DE)
Inventor: KUECHLER H
IPC: C07C1/20
Filed: 1999-04-16
Granted: 2004-02-12
Abstract: The present invention relates to a process for catalytically converting a feedstock comprising an oxygenates to olefins with direct product quenching to increase heat recovery and to improve heat integration.
Patent DE-69916090-D1 (DE)
Inventor: DHAINAUT JILDAZ
IPC: C07D311/72
Filed: 1999-09-15
Granted: 2004-05-06
Abstract: The invention concerns a novel method for preparing vitamin E. More particularly, it concerns a novel method for the condensation of trimethylhydroquinone and isophytol.
Patent DE-69918272-D1 (DE)
Inventor: CHOBOTOV V
IPC: A61F2/24
Filed: 1999-02-09
Granted: 2004-07-29
Abstract: An endovascular graft which is configured to conform to the morphology of the vessel to be treated and which is made from an inflatable structure having a proximal end with a proximal inflatable cuff and a distal end with a distal inflatable cuff. At least one elongated inflatable channel is disposed between and in fluid communication with fluid tight chambers of the inflatable cuffs which may contain rupture discs therebetween which can be configured to rupture at different pressures. A thin flexible barrier disposed between the inflatable cuffs and the elongated inflatable channel of the frame so as to form a tubular structure defining a longitudinal channel to confine a flow of blood or other fluid therethrough. The graft may also have an expansion member attached to the proximal end of the graft which is preferably made of linked expandable rings of pseudoelastic shape memory alloy which is self-expanding and prevents axial displacement of the graft once it is deployed.