Patent CA-3015509-C (CA)
Title: Methods for preventing or reducing acute kidney injury
Inventor: MITIN NATALIA
IPC: C12Q1/6809
Filed: 2017-02-22
Granted: 2023-10-03
Abstract: CA 03015509 2018-08-22 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) CORRECTED VERSION (19) World Intellectual Property 11H11 11111111 0 11101 010H111010 11111 0111010 1110 lH 011111111 1111111110 11111101111 Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/147195 A9 31 August 2017 (31.08.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every G01N 33/00 (2006.01) G01N 33/483 (2006.01) kind of national protection available): AE, AG, AL, AM, G01N 33/48 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (21) International Application Number: DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, PCT/U52017/018962 HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, (22) International Filing Date: KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, 22 February 2017 (22.02.2017) MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (25) Filing Language: English SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (26) Publication Language: English TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 62/298,394 22 February 2016 (22.02.2016) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (71) Applicant: HEALTHSPANDX [US/US]; 104 T.W. UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, Alexander Dr., Building 4A, Durham, NC 27709 (US). TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (72) Inventor: MITIN, Natalia; 9 Aurora Court, Durham, NC EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 27713 (US). MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (74) Agent: RICHARDSON, Bryan, T. et al.; Brinks Gilson & KM, ML, MR, NE, SN, TD, TG). Lione, P.O. Box 110285, Research Triangle Park, NC 27709 (US). (54) Title: METHODS FOR PREVENTING OR REDUCING ACUTE KIDNEY INJURY (57) Abstract: Described herein are methods, kits, and composi-tions of matter for identifying subjects that are at risk for devel-pi 6 oping acute kidney injury. These methods, kits, and compositions 00 are useful for identifying subjects at risk for developing acute kid-= 1 __________________________ is, nnnnn ney injury prior to undergoing a surgical intervention, such as car-= ' mg as diovascular surgery, or prior to initiating chemotherapy. In par-on, w/ 80 -ticular, levels of p16 and/or p14 are useful in identifying the risk in Jo / of acute kidney injury these subjects. Also, described herein are non-naturally occurring DNA sequences that correspond to a por = ao al at ,V --5 tion or all of p16 and/or p14, which are useful in identifying sub-jects at risk for developing acute kidney injury. a) 40 " = awe / 0 20 40 60 BO 100 100-Specificity FIGURE I [Continued on next page] CA 03015509 2018-08-22 WO 2017/147195 A9 111111111111111111111101111111101111111111111111111110 lH0ICIR0MII10IIII Published: ¨ with international search report (Art. 21(3)) ¨ with sequence listing part of description (Rule 5.2(a)) ¨ with information concerning authorization of rectification of an obvious mistake under Rule 91.3 (b) (Rule 48.2(i)) (48) Date of publication of this corrected version: 09 November 2017 (09.11.2017) (15) Information about Correction: see Notice of 09 November 2017 (09.11.2017)