Patent SG-11201805870Y-A (SG)
Title: Bispecific t cell engaging antibody constructs
Inventor: RAUM TOBIAS
IPC: C07K16/30
Filed: 2017-02-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 111111110111101110101011111010111110111011111111101011101101111101111011111 International Bureau ... ..... ..Yi j (10) International Publication Number (43) International Publication Date ..... .....!;,' WO 2017/134140 Al 10 August 2017(10.08.2017) WIPO I PCT (51) International Patent Classification: (74) Agents: WEINZIERL, Gerhard et al.; Schiweck Weinzi- CO7K 16/28 (2006.01) C07K 16/30 (2006.01) erl Koch, European Patent Attorneys, Landsberger Strasse 98, 80339 Munich (DE). (21) International Application Number: PCT/EP2017/052212 (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, 2 February 2017 (02.02.2017) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (26) Publication Language: English KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (30) Priority Data: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 62/290,861 3 February 2016 (03.02.2016) US NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (71) Applicant: AMGEN RESEARCH (MUNICH) GMBH TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, [DE/DE]; Staffelseestrasse 2, 81477 Munich (DE). ZA, ZM, ZW. (72) Inventors: RAUM, Tobias; c/o Amgen Research (Mu- (84) Designated States (unless otherwise indicated, for every nich) GmbH, Staffelseestrasse 2, 81477 Munich (DE). kind of regional protection available): ARIPO (BW, GH, MUENZ, Markus; c/o Amgen Research (Munich) GmbH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Staffelseestrasse 2, 81477 Munich (DE). BROZY, Jo- TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, hannes; c/o Amgen Research (Munich) GmbH, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, — Staffelseestrasse 2, 81477 Munich (DE). KUFER, Peter; DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, c/o Amgen Research (Munich) GmbH, Staffelseestrasse 2, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, = 81477 Munich (DE). HOFFMANN, Patrick; c/o Amgen SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Research (Munich) GmbH, Staffelseestrasse 2, 81477 Mu- GW, KM, ML, MR, NE, SN, TD, TG). = nich (DE). FRIEDRICH, Matthias; c/o Amgen Research GmbH, Staffelseestrasse 2, 81477 Munich (DE). Published: (Munich) = RATTEL, Benno; c/o Amgen Research (Munich) GmbH, — with international search report (Art. 21(3)) = Staffelseestrasse 2, 81477 Munich (DE). BOGNER, before the expiration of the time limit for amending the Pamela; c/o Amgen Research (Munich) GmbH, claims and to be republished in the event of receipt of Staffelseestrasse 2, 81477 Munich (DE). WOLF, Andreas; amendments (Rule 48.2(h)) c/o Amgen Research (Munich) GmbH, Staffelseestrasse 2, 81477 Munich (DE). POMPE, Cornelius; c/o Amgen Re- search (Munich) GmbH, Staffelseestrasse 2, 81477 Munich (DE). = = = = = = = = Il © 7r 11 7r M 11 (54) Title: BISPECIFIC T CELL ENGAGING ANTIBODY CONSTRUCTS Il C (57) : The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a ei first domain binding to a target cell surface antigen, a second domain binding to an extracellular epitope of the human and/or the O Macaca CDR chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, en- coding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.