Patent SG-11201907571W-A (SG)
Title: Therapeutic compositions and related methods for photoimmunotherapy
Inventor: GARCIA-GUZMAN MIGUEL
IPC: A61K47/68
Filed: 2018-02-22
Abstract: International Patent Classification: (72) Inventors: GARCIA-GUZMAN, Miguel; 11080 Roselle A61K 41/00 (2006.01) A61K 47/62 (2017.01) Street, San Diego, California 92121 (US). MAKINGS, A61K 47/42 (2017.01) A61K 47/68 (2017.01) Lewis R.; 11080 Roselle Street, San Diego, California A61K 47/50 (2017.01) A61P 35/00 (2006.01) 92121 (US). CHIN, Eileen Sun; 11080 Roselle Street, San (21) International Application Number: Diego, California 92121 (US). PCT/US2018/019294 (22) International Filing Date: 22 February 2018 (22.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/462,898 23 February 2017 (23.02.2017) US (71) Applicant: ASPYRIAN THERAPEUTICS, INC. [US/US]; 11080 Roselle Street, San Diego, California 92121 (US). (74) Agent: AHN, Sejin; Morrison & Foerster LLP, 12531 High Bluff Drive, Suite 100, San Diego, California 92130 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 30 August 2018 (30.08.2018) WIPO I PCT (54) Title: THERAPEUTIC COMPOSITIONS AND RELATED METHODS FOR PHOTOIMMUNOTHERAPY FIG. 1A 0111111010 0111 °nolo monim H OH oimIE (10) International Publication Number WO 2018/156815 Al 25 O I • 20 72 • , -- c 15 0, ° co • -q. 0 10 • -a • ez • 5 u_ 0 ENo light 0 Light 00 00 O C A431+CetuximabIR700 FaDu+Cetuximab I R700 Treatment (57) : Provided are conjugates, e.g., dual conjugates, compositions and methods for use in photoimmunotherapy, such as photoimmunotherapy induced by activation of a phthalocyanine dye in the dual conjugate. In some embodiments, the dual conjugate contains a targeting molecule and a therapeutic agent. In some embodiments, the phthalocyanine-dye in the conjugate, e.g., dual con- jugate, can be activated by irradiation with near-infrared light. Also provided are therapeutic methods using the conjugates, e.g., dual conjugates, and compositions for treatment of a lesion associated with diseases and conditions, including tumors or cancers. Features of the conjugates, e.g., dual conjugates, compositions, combinations and methods, including the dose of the conjugate, provide various advantages, such as efficient delivery and targeting of the therapeutic agent to the site of the lesion. [Continued on next page] WO 2018/156815 Al MIDEDIMOMOIDEIREEMOMOMHOHOMMIS SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a))