Patent ES-2453075-T3 (ES)
Title: Antagonistas de TRPV4
Inventor: BURY MICHAEL
IPC: A01N43/38
Filed: 2009-07-24
Granted: 2014-04-03
Abstract: Un compuesto seleccionado del grupo que consiste en: N-((1S)-1-{[(1S,4S)-5-(1H-indol-2-ilcarbonil)-2,5-diazabiciclo[2.2.1]hept-2-il]carbonil}-2,2-dimetilpropil)-1H-indol-2- carboxamida; N-[(1S)-2,2-dimetil-1-({(1S,4S)-5-[(5-5 fenil-2-tienil)carbonil]-2,5-diazabiciclo[2.2.1]hept-2-il}carbonil)propil]-1H-indol-2- carboxamida; N-[(1S)-1-({(1S,4S)-5-[(2R)-2,3-dihidro-1H-indol-2-ilcarbonil]-2,5-diazabiciclo[2.2.1]hept-2-il}carbonil)-2,2- dimetilpropil]-1H-indol-2-carboxamida; N-[(1S)-1-({(1S,4S)-5-[(6-fluoro-1H-indol-2-il)carbonil]-2,5-diazabiciclo[2.2.1]hept-2-il}carbonil)-2,2-dimetilpropil]-1H10 indol-2-carboxamida; N-[(1S)-1-({(1S,4S)-5-[(7-fluoro-1H-indol-2-il)carbonil]-2,5-diazabiciclo[2.2.1]hept-2-il}carbonil)-2,2-dimetilpropil]-1Hindol- 2-carboxamida; N-{(1S)-2,2-dimetil-1-[((1S,4S)-5-{[7-(metiloxi)-1H-indol-2-il]carbonil}-2,5-diazabiciclo[2.2.1]hept-2-il)carbonil]propil}- 1H-indol-2-carboxamida; N-((1S)-1-{[(1S,4S)-5-(1H-indazol-3-ilcarbonil)-2,5-diazabiciclo[2.2.1]hept-2-il]carbonil}-2,2-dimetilpropil)-1H-indol-2- carboxamida; N-((1S)-1-{[(S,4S)-5-(1H-indol-7-ilcarbonil)-2,5-diazabiciclo[2.2.1]hept-2-il]carbonil}-2,2-dimetilpropil)-1H-indol-2- carboxamida; N-((1S)-1-{[(1S,4S)-5-(1H-indol-6-ilcarbonil)-2,5-diazabiciclo[2.2.1]hept-2-il]carbonil}-2,2-dimetilpropil)-1H-indol-2- carboxamida; N-[(1S)-2,2-dimetil-1-({(1S,4S)-5-[(7-metil-1H-indol-2-il)carbonil]-2,5-diazabiciclo[2.2.1]hept-2-il}carbonil)propil]-1Hindol- 2-carboxamida; N-{(1S)-2,2-dimetil-1-[((1S,4S)-5-{[5-(metiloxi)-1H-indol-2-il]carbonil}-2,5-diazabiciclo[2.2.1]hept-2-il)carbonil]propil}- 1H-indol-2-carboxamida; N-[(1S)-2,2-dimetil-1-({(1S,4S)-5-[(5-metil-1H-indol-2-il)carbonil]-2,5-diazabiciclo[2.2.1]hept-2-il}carbonil)propil]-1Hindol- 2-carboxamida; N-[(1S)-1-({(1S,4S)-5-[(5-fluoro-1H-indol-2-il)carbonil]-2,5-diazabiciclo[2.2.1]hept-2-il}carbonil)-2,2-dimetilpropil]-1Hindol- 2-carboxamida; N-((1S)-1-{[(1S,4S)-5-(1H-indol-4-ilcarbonil)-2,5-diazabiciclo[2.2.1]hept-2-il]carbonil}-2,2-dimetilpropil)-1H-indol-2- carboxamida; N-[(1S)-2,2-dimetil-1-({(1S,4S)-5-[(1-metil-1H-indol-2-il)carbonil]-2,5-diazabiciclo[2.2.1]hept-2-il}carbonil)propil]-1Hindol- 2-carboxamida; N-((1S)-1-{[(1S,4S)-5-(1H-indol-3-ilcarbonil)-2,5-diazabiciclo[2.2.1]hept-2-il]carbonil}-2,2-dimetilpropil)-1H-indol-2- carboxamida; N-((1S)-1-{[(1S,4S)-5-(1H-indol-5-ilcarbonil)-2,5-diazabiciclo[2.2.1]hept-2-il]carbonil}-2,2-dimetilpropil)-1H-indol-2- carboxamida; N-((1S)-1-{[(1S,4S)-5-(1-benzotien-2-ilcarbonil)-2,5-diazabiciclo[2.2.1]hept-2-il]carbonil}-2,2-dimetilpropil)-1H-indol-2- carboxamida; N-((1S)-1-{[(1S,4S)-5-(2-indolizinilcarbonil)-2,5-diazabiciclo[2.2.1]hept-2-il]carbonil}-2,2-dimetilpropil)-1H-indol-2- carboxamida; N-((1S)-1-{[(1S,4S)-5-(1-benzofuran-2-ilcarbonil)-2,5-diazabiciclo[2.2.1]hept-2-il]carbonil}-2,2-dimetilpropil)-1H-indol- 2-carboxamida; N-{(1S)-2,2-dimetil-1-[((1S,4S)-5-{[6-(metiloxi)-1H-indol-2-il]carbonil}-2,5-diazabiciclo[2.2.1]hept-2-il)carbonil]propil}- 1H-indol-2-carboxamida; N-[(1S)-2,2-dimetil-1-({(1S,4S)-5-[(6-metil-1H-indol-2-il)carbonil]-2,5-diazabiciclo[2.2.1]hept-2-il}carbonil)propil]-1Hindol- 2-carboxamida.