Patent SG-11201807832V-A (SG)
Title: Extended release conjugates of exenatide analogs
Inventor: SCHNEIDER ERIC L
IPC: A61K38/00
Filed: 2017-03-16
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 111111110111101110101011111010111110111011110110111010111011111111101111011111 International Bureau 0.. .... .. (10) International Publication Number (43) International Publication Date ...... ... WO 2017/161174 Al 21 September 2017 (21.09.2017) WIP0 I PCT (51) International Patent Classification: (74) Agents: MURASHIGE, Kate H. et al.; Morrison & Foer- A61K 38/00 (2006.01) C07K 14/605 (2006.01) ster LLP, 12531 High Bluff Drive, Suite 100, San Diego, CA 92130-2040 (US). (21) International Application Number: PCT/US2017/022791 (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, 16 March 2017 (16.03.2017) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (26) Publication Language: English KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (30) Priority Data: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 62/309,330 16 March 2016 (16.03.2016) US NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, 62/416,058 1 November 2016 (01.11.2016) US RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (71) Applicant: PROLYNX LLC [US/US]; 455 Mission Bay ZA, ZM, ZW. Blvd. South, Suite 145, San Francisco, CA 94158 (US). (84) Designated States (unless otherwise indicated, for every (72) Inventors: SCHNEIDER, Eric L.; c/o Prolynx LLC, 455 kind of regional protection available): ARIPO (BW, GH, Mission Bay Blvd South, Suite 145, San Francisco, CA GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 94158 (US). HEARN, Brian; c/o Prolynx LLC, 455 Mis- TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, sion Bay Blvd South, Suite 145, San Francisco, CA 91158 TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, — (US). HENISE, Jeffrey C.; c/o Prolynx LLC, 455 Mission DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, — _ Bay Blvd South, Suite 145, San Francisco, CA 94158 LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (US). ASHLEY, Gary W.; c/o Prolynx LLC, 455 Mission SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Bay Blvd South, Suite 145, San Francisco, CA 94158 GW, KM, ML, MR, NE, SN, TD, TG). = (US). SANTI, Daniel, V.; C/o Prolynx Llc, 455 Mission Bay Blvd South, Suite 145, San Francisco, CA 94158 Published: (US). — with international search report (Art. 21(3)) = = = [Continued on next page] = Title: EXTENDED RELEASE CONJUGATES OF EXENATIDE ANALOGS (54) = = = 0* = = 0' = = , • _ Y2.-tonmats,0 koimirstiatitl 1-1 7r Ir ... ' 11 ,—I Figure 4 1-1 IN 1-1 (57) : Extended-release conjugates of stabilized GLP-1 agonists balance agonist stability with release rates to provide long 0 lasting administration to treat diabetes and related conditions on once-a-month or less frequent dosing schedules. ei 0 WO 2017/161174 Al 1#11101MO1101DION0101301110110101011101MMOVOIS — before the expiration of the time limit for amending the claims and amendments (Rule to be republished 48.2(h)) in the event of receipt of