Patent SG-11201809781P-A (SG)
Title: Novel peptides, combination of peptides as targets and for use in immunotherapy against gallbladder cancer and cholangiocarcinoma and other cancers
Inventor: MAHR ANDREA
IPC: C12N9/12
Filed: 2017-05-23
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 30 November 2017 (30.11.2017) WIPO I PCT (51) International Patent Classification: MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, A61K 38/17 (2006.01) Cl 2N 9/12 (2006.01) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, A61K 39/00 (2006.01) KM, ML, MR, NE, SN, TD, TG). (21) International Application Number: (22) International Filing Date: PCT/EP2017/062334 Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) 23 May 2017 (23.05.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1609193.6 25 May 2016 (25.05.2016) GB 62/341,367 25 May 2016 (25.05.2016) US (71) Applicant: IMMATICS BIOTECHNOLOGIES GMBH [DE/DE]; Paul-Ehrlich-Strasse 15, 72076 Tuebingen (DE). (72) Inventors: MAHR, Andrea; Kirschenweg 22, 72076 Tiibingen (DE). WEINSCHENK, Toni; Im Morgenrain 15, 73773 Aichwald (DE). WIEBE, Anita; Quellenstrasse 49, 72124 Ruebgarten (DE). SCHOOR, Oliver; Eich- haldenstrasse 19, 72074 Tiibingen (DE). FRITSCHE, Jens; Larchenweg 11, 72144 Dusslingen (DE). SINGH, Harpreet; 5122 Morningside Dr., Apt. 525, 77005 Houston (DE). (74) Agent: BOEHMERT & BOEHMERT; Jan B. KRAUSS, Pettenkoferstrasse 20 - 22, 80336 Munich (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 1-1 (54) Title: NOVEL PEPTIDES, COMBINATION OF PEPTIDES AS TARGETS AND FOR USE IN IMMUNOTHERAPY O AGAINST GALLBLADDER CANCER AND CHOLANGIOCARCINOMA AND OTHER CANCERS GC (57) : The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In O particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated 1-1 N T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, O soluble T-cell receptors, and other binding molecules. C o DID lII D ono 11o1olmo 1101 oimIE (10) International Publication Number WO 2017/202806 Al