baber/WOPTO huggingface dataset:
Patent CA-2950259-C (CA)
Inventor: KAWAGUCHI KENICHI
IPC: A61K31/436
Filed: 2015-05-28
Granted: 2022-08-23
Abstract: The problem to be solved by the present invention is to provide a compound suitable for a pharmaceutical composition, specifically a pharmaceutically composition for treating nocturia. The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, would maintain and/or increase an endogenous AVP level to enhance the antidiuretic effect, which would contribute to a decreased number of nocturnal voids, and have extensively studied compounds which inhibit P-LAP. As a result, the inventors have found that (2R)-3-amino-2-{[4-(substituted pyridine)-2-yl]methyl}-2-hydroxy-propanoic acid derivatives have excellent P-LAP inhibitory activity. The inventors have evaluated antidiuretic effects in water-loaded rats and have found that the compounds increase endogenous AVP levels by inhibiting P-LAP and consequently reduce urine production. The present invention therefore provides compounds of formula (I): (see formula I) which are useful as an agent for treating nocturia based on P-LAP inhibition.
Patent CA-2961652-C (CA)
Title: Carton having texture
Inventor: SMALLEY BRIAN
IPC: B65D71/34
Filed: 2015-10-30
Granted: 2019-08-13
Abstract: A carton for holding a plurality of containers is disclosed. The carton includes a plurality of panels. The plurality of panels includes a top panel, a bottom panel, a first side panel, and a second side panel. The carton includes a plurality of end flaps. Each end flap of the plurality of end flaps is respectively foldably connected to a respective panel of the plurality of panels for at least partially closing an end of the carton. The carton further includes a plurality of lines of weakening positioned in at least one portion of the carton. The at least one portion of the carton being selected from the group consisting of at least one panel of the plurality of panels and at least one end flap of the plurality of end flaps. The plurality of lines of weakening forms at least one texture in the exterior of the carton.
Patent CA-2972411-C (CA)
Inventor: LIU ZHENGCHUN
IPC: E21B43/12
Filed: 2015-05-07
Granted: 2022-04-19
Abstract: A method for simulating the effects of syntactic foam on annular pressure buildup during annular fluid expansion in a wellbore to mitigate annular pressure buildup in the wellbore comprises the steps of: calculating one of an elastic foam volume change in a region of a casing string annulus and a crushed foam volume change in the region of the casing string annulus; calculating an adjusted casing volume change for the region in the casing string annulus; and calculating an adjusted annular pressure buildup for the region in the casing string annulus.
Patent CA-2977104-C (CA)
Inventor: WU JIN
IPC: B32B27/42
Filed: 2017-08-21
Granted: 2021-02-16
Abstract: Un élément daide au transfert comprend une pluralité de couches, lune des couches étant une couche de film de contrôle constituée dun polyéther fluoré à base de poly(oxétane) à terminaison hydroxyle.
Patent CA-2978346-C (CA)
Title: Laminated sealing member for prosthetic heart valve
Inventor: PELLED ITAI
IPC: A61F2/24
Filed: 2016-04-28
Granted: 2023-10-17
Abstract: The present disclosure relates to laminated sealing members for prosthetic valves and methods of making the same. In a representative embodiment, an implantable prosthetic valve that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration comprises an annular frame having an inflow end and an outflow end, a leaflet structure positioned within the frame and secured thereto, and a laminate sealing member comprising an encapsulating material. The laminate sealing member has a main portion that encapsulates at least a portion of the frame and an end portion extending from the inflow end of the frame, and the end portion of the laminate sealing member is folded to form a cuff adjacent the inflow end of the frame and secured to the main portion of the laminate sealing member.
Patent CA-2990585-C (CA)
Inventor: LAKHOV DMITRIY ALEKSANDROVICH
IPC: F22B1/02
Filed: 2016-06-02
Granted: 2021-09-21
Abstract: The invention relates to steam generators for nuclear power plants. The present steam generator comprises a horizontal housing, a primary loop inlet header and a primary loop outlet header, which are arranged horizontally, heat exchange tubes, which are arranged in vertical planes, and a feedwater dispensing device. The invention is directed toward reducing thermohydraulic inequality in a steam generator, achieving better filling of the steam generator with heat exchange tubes, and reducing the concentration of corrosive impurities in the region of the weld seam between the primary loop headers and the horizontal housing.
Patent CA-3000895-C (CA)
Title: Use of a calcium sulfate comprising 2-k mortar system based on aluminous cement in anchoring applications to increase load values and reduce shrinkage
Inventor: PFEIL ARMIN
IPC: C04B40/06
Filed: 2016-10-19
Granted: 2023-09-19
Abstract: The present invention pertains to a use of a calcium sulfate comprising 2-K mortar system for a chemical fastening of anchoring means in mineral surfaces. Besides the calcium sulfate, the mortar system comprises a curable aluminous cement component A and an initiator component B for initiating the curing process, component A further comprising at least one blocking agent selected from the group consisting of phosphoric acid, metaphosphoric acid, phosphorous acid and phosphonic acids, at least one plasticizer and water, and component B comprising an initiator, at least one retarder, at least one mineral filler and water. Due to the presence of the calcium sulfate the hardened mortar exhibits increased load values and reduced shrinkage. The mortar system is used for chemical fastening of anchoring means, preferably of metal elements, in mineral surfaces, such as structures made of brickwork, concrete, pervious concrete or natural stone.
Patent CA-3012651-C (CA)
Inventor: GARVIN JAMES
IPC: F04D13/14
Filed: 2018-07-26
Granted: 2021-03-23
Abstract: A pump system includes dual centrifugal pumps mounted on a fabricated skid. Both pumps are belt driven by one motor. The pumps are piped with three two-way valves and crossover piping configured such that the pumps can be operated in either series or parallel flow using a single inlet and outlet for the system.
Patent CA-3014330-C (CA)
Title: Appareil de buse assiste par le vide et procede utilisant ledit appareil
Inventor: COROMINAS FRANCESC
IPC: B67C3/26
Filed: 2017-03-06
Granted: 2020-11-03
Abstract: L'invention concerne un appareil, qui comporte une buse (10), un conduit d'écoulement de fluide (30), une ouverture d'évacuation d'écoulement de fluide, une surface d'ouverture d'évacuation d'écoulement de fluide, une vanne d'écoulement de fluide (35), une source de vide (55), un conduit de vide (50), une ouverture de vide, une vanne de vide (70), et une surface d'ouverture de vide, l'ouverture de vide étant spatialement proche de l'ouverture d'évacuation d'écoulement de fluide, le rapport de la surface d'ouverture de vide à la surface d'ouverture d'évacuation d'écoulement de fluide étant inférieur ou égal à 1, et la vanne d'écoulement de fluide et la vanne de vide étant couplées.
Patent CA-3014343-C (CA)
Inventor: HUFFER SCOTT WILLIAM
IPC: B65D65/40
Filed: 2015-02-16
Granted: 2020-08-25
Abstract: A container is provided that has a first web comprising a laminate of a first film layer and a second film layer, a second web peripherally sealed to the first web so as to form a compartment therebetween, and an air-activated material disposed within the compartment. The first film layer is adhered to the second film layer via an adhesive layer. At least a portion of the first film layer is configured to be separated from the second film layer to reveal a plurality of openings in the first film layer so as to allow air to enter the compartment. The air-activated material is configured to react with the air entering the compartment via the openings to activate the material. Prior to separation of the second film layer from the first film layer, the container is configured to allow ingress of oxygen into the compartment at a rate less than approximately 3 cc per 100 in2 per 24 hrs. at 23°C.
Patent CA-3017054-C (CA)
Inventor: JOCHUM HERBERT
IPC: A61H19/00
Filed: 2017-05-22
Granted: 2022-06-21
Abstract: L'invention concerne un dispositif de fixation (1) d'un dispositif d'extension du pénis doté d'un élément de couplage (5) pour exercer une force de traction sur un pénis et doté d'un dispositif de mesure de la force de traction (7, 8, 19, 27) qui est caractérisé en ce qu'un premier composant électronique (9) et une première source de courant (10) sont présents, le dispositif de mesure de la force de traction (7, 8, 19, 27) détermine électriquement ou électroniquement la valeur de mesure de la tension exercée conjointement avec le premier composant électronique (9), et le premier composant électronique (9) comporte un premier dispositif radio pour transmettre la valeur de mesure déterminée à un récepteur externe. Avec ce dispositif, il est possible de transmettre une valeur de mesure appropriée, en particulier la valeur de mesure de la force de traction exercée, à partir de la zone sensible dans laquelle est utilisé le dispositif de fixation selon l'invention à un dispositif externe, par exemple à une application d'un téléphone cellulaire.
Patent CA-3021063-C (CA)
Title: Double glass module with ethylene-vinyl acetate copolymer barrier structure
Inventor: HUANG JUNZHE
IPC: H01L31/052
Filed: 2017-03-30
Granted: 2020-12-15
Abstract: A double glass module, comprising a front panel glass (10), a first adhesive film (20), a solar cell pack group (30), a second adhesive film (40), aluminum foil (50), a third adhesive film (60) and a rear panel glass (70) successively stacked. The aluminum foil is added in front of the rear panel glass of a double glass module, and since the aluminum foil has a high light reflectivity, the reflection effect for transmitted light energy is improved, so that the power of the double glass module is significantly enhanced. Meanwhile, since the aluminum foil has a better heat conductivity, the heat generated by the solar cell pack group can be conducted and dissipated in time, so that the temperature of the double glass module is reduced in time, thereby reducing a temperature coefficient impact factor, and prolonging a daily mean efficient power output time of the double glass module.
Patent CA-3025341-C (CA)
Title: Training method and system for directional transmission in wireless communication
Inventor: ABDALLAH RAMY
IPC: H04B7/06
Filed: 2017-05-26
Granted: 2021-09-14
Abstract: A wireless radio communication apparatus and method in which directional transmission, also known as beamforming, training is performed on transmissions between multiple wireless radio communication devices participating in a local network. A sector level sweep (SLS) process uses transmitter sector sweep (TXSS) training, which includes transmitting a sector sweep (SSW) followed by generating sector sweep (SSW) feedback to other nodes in the local network, with optimum transmit sector information being exchanged between nodes. Embodiments include a power save mode, a delayed SSW feedback mode, and an embedded polling and feedback mode.
Patent CA-3027536-C (CA)
Title: Engine
Inventor: OLTMANS BRET ALLEN
IPC: F02B67/04
Filed: 2011-09-23
Granted: 2022-04-12
Abstract: An engine comprises a crankcase, a crankshaft journalled in the crankcase, a piston coupled to the crankshaft, a cylinder in which the piston reciprocates, and a head positioned over the cylinder, wherein a water pump assembly is mounted over a first end of the crankshaft and is drivingly coupled to the crankshaft.
Patent CA-3031509-C (CA)
Title: Membrane de polyimide pour la separation de gaz et sa methode de preparation
Inventor: LEE YOUNG MOO
IPC: B01D53/22
Filed: 2017-07-18
Granted: 2021-10-26
Abstract: La présente invention concerne une membrane de séparation de gaz polymère thermiquement réarrangée ayant une structure réticulée fluorée, et un procédé de préparation associé. La membrane de séparation de gaz polymère thermiquement réarrangée ayant une structure réticulée fluorée, préparée par la présente invention, a des atomes de fluor répartis dans une membrane polymère thermiquement réagencée ayant une structure réticulée, de manière à présenter un gradient de concentration avec la surface, et est formée en une structure à trois couches comprenant : une couche de dépôt de fluor; une couche de transition; et une couche de base polymère réarrangée thermiquement, ce qui permet d'obtenir une sélectivité remarquablement accrue par rapport à celle d'une membrane classique de séparation de gaz commercialisée et, en particulier, permettant à l'hélium d'être séparé avec un degré de pureté et un taux de récupération élevés dans un puits de gaz naturel et similaire, même à travers une petite zone de membrane, et ainsi la membrane peut être commercialisée.
Patent CA-3031966-C (CA)
Title: Bande lumineuse a del a eclairage uniforme
Inventor: LI XIAOPING
IPC: F21K9/68
Filed: 2019-01-30
Granted: 2021-02-16
Abstract: Linvention concerne une bande lumineuse à DEL à éclairage uniforme, comprenant un boîtier externe, un boîtier interne et un composant électroluminescent, le boîtier externe comprend une couche de transmission de la lumière et une couche réfléchissante, la couche réfléchissante est disposée sur deux côtés de la couche de transmission de la lumière et sétend vers le fond de la couche de transmission de la lumière, la couche de transmission de la lumière est pourvue dune partie vacante, la lumière émise par léclairage à DEL est réfractée par la partie vacante et ensuite émise à travers la surface de sortie de lumière de la couche de transmission de la lumière. Dans la présente invention, la lumière du grand et du petit angle émise par léclairage à DEL est réfléchie et réfractée par la coopération mutuelle de la partie vacante et de la couche réfléchissante, et finalement émise à travers la surface de sortie de lumière de la couche de transmission de la lumière rendant la lumière de la bande de lumière plus uniforme et améliorant leffet de décoration et déclairage de la bande de lumière.
Patent CA-3037019-C (CA)
Inventor: KNIGHT JAMES A
IPC: C02F7/00
Filed: 2019-03-18
Granted: 2021-10-26
Abstract: A safety access system for use on floats, typically in the field of water and wastewater treatment, the system including rotatable and removable handrails and sockets attached to the float to receive the handrails.
Patent CA-3039109-C (CA)
Title: Configuration for data and reference signal transmissions with shortened transmission time intervals
Inventor: HOSSEINI SEYEDKIANOUSH
IPC: H04L5/00
Filed: 2017-11-09
Granted: 2022-11-29
Abstract: Techniques provide for identifying uplink resources that are to be used for uplink transmissions using shortened transmission time intervals (sTTIs), such as low latency or high reliability transmissions. A reference signal (RS) configuration for a three-symbol sTTI, including locations of one or more RS symbols and one or more data symbols within the sTTI may be identified. The RS configuration, along with the allocation of uplink resources, may be provided to a user equipment (UE) which may transmit uplink communications using the allocated uplink resources.
Patent CA-3039404-C (CA)
Title: Aminooxylipids for construction of self-assembling liposomal systems enabling their subsequent modification by biologically functional molecules
Inventor: LEDVINA MIROSLAV
IPC: C07C235/08
Filed: 2017-11-02
Granted: 2021-09-07
Abstract: New aminooxylipids of general formula (I), wherein n1 = 5-30 and X is polymethylene linker of the general formula (II) where n2 = 2 -10, or X is polyethylene glycol linker of the general formula (III), wherein n3 = 1-14, are provided. A method of preparation of the aminooxylipids of general formula (I) characterized in that the acylation of N-tert-butoxycarbonyl-polymethylenediamine {(CH3)3C-0-(C=0)-HN-(CH2)n-N H2, n = 2 -13}, or N-tert- butoxycarbonyl-polyethyleglycoldiamine {(CH3)3C-0-(C=0)-HN-(CH2)2-[0-(CH2)]n-0-(CH2)2NH2, n = 1-14} with in position C(2) symmetrically branched fatty acids of general formula (IV), wherein n1 = 5-30, in the presence of condensation reagent, or from acid of general formula (IV) derived acylchloride of general formula (V) wherein n1 = 5-30, produces N-Boc-aminolipids of general formula (VI), wherein n1 = 5-30 a X is polymethylene linker of the general formula (II) or X is polyethylene glycol linker of the general formula (III). These are converted by debocylation to aminolipids of general formula (VII), wherein n1 = 5-30 and X is polymethylene linker of the general formula (II) or X is polyethylene glycol linker of the general formula (III). By their condensation with N-terf-butoxycarbonyl-aminooxyacetic acid in the presence of condensation reagent, N-Boc-aminooxylipids of general formula (VIII), where in n1 = 5- 30 and X is polymethylene linker of the general formula (II) or X is polyethylene glycol linker of the general formula (III), are obtained, which by debocylation afford aminooxylipids of general formula (I). Acylchlorides of general formula (V) are prepared by reaction of acid of general formula (IV) with oxalylchloride in the presence of catalytic amount of N, N-dimethylformamide in organic aprotic solvent. The use of nontoxic aminooxylipids of the general formula I for construction of nontoxic self-assembly liposomal carriers of therapeutics presenting aminooxy groups and so-called "post-liposomal" modification of these carriers with biologically functional molecules using oxime ligation technique (binding counterparts: aminooxy group and aldehyde or ketone group).
Patent CA-3039968-C (CA)
Inventor: PARK JOO-SUNG
IPC: H04L27/26
Filed: 2016-06-09
Granted: 2021-01-12
Abstract: Un procédé est décrit pour déterminer des tonalités réservées à utiliser pour la réduction dun rapport de puissance sommet-moyenne (PAPR) dun signal comprend : sélectionner aléatoirement des indices de porteuses pour les tonalités réservées et générer un signal de noyau en fonction des indices sélectionnés aléatoirement; calculer une valeur moyenne de référence du signal de noyau aux fins de comparaison, comparer cette valeur avec une valeur moyenne de référence stockée préalablement et déterminer de façon préliminaire les indices de porteuses des tonalités réservées en fonction de la comparaison; réorganiser aléatoirement un ordre des indices préliminaires; calculer la valeur moyenne de référence aux fins de comparaison en changeant chacun des indices réorganisés des tonalités réservées; et, enfin, déterminer les indices de porteuses pour lesquelles la valeur moyenne de référence comparative calculée devient la plus petite valeur moyenne de référence comme indices des tonalités réservées.
Patent CA-3041501-C (CA)
Inventor: FITCH EDWARD PAUL
IPC: B01J13/00
Filed: 2015-04-29
Granted: 2020-09-22
Abstract: A method of producing a liquid pharmaceutical suspension by mixing magnesium aluminum silicate, gellan gum, bismuth subsalicylate, and methyl cellulose.
Patent CA-3042030-C (CA)
Inventor: PERNODET NADINE
IPC: A61Q19/08
Filed: 2017-10-26
Granted: 2021-03-09
Abstract: L'invention concerne des compositions topiques contenant au moins un ingrédient qui stimule l'activité de Mir-146a dans des cellules cutanées, des méthodes de traitement de la peau et des méthodes de criblage d'ingrédients qui stimulent l'activité de Mir-146a.
Patent CA-3042595-C (CA)
Inventor: YE BAOHUAN
IPC: C07D519/00
Filed: 2017-10-18
Granted: 2022-07-12
Abstract: La présente invention concerne le composé de pyrazolopyrimidine de formule (I) et un sel pharmaceutiquement acceptable de celui-ci. De tels composés peuvent être utilisés pour inhiber l'activité d'une protéine kinase PI3K, et peuvent également être utilisés pour traiter des maladies induites par PI3K, telles que des cancers, une inflammation et des maladies auto-immunes. La présente invention concerne également une composition pharmaceutique contenant de tels composés, un procédé de préparation de tels composés et l'utilisation de tels composés ou composition pharmaceutique dans la préparation de médicaments pour le traitement de cancers, d'inflammations et de maladies auto-immunes induites par PI3K.
Patent CA-3045336-C (CA)
Inventor: GALLAGHER BOBBY JAMES
IPC: E21B33/06
Filed: 2017-10-23
Granted: 2021-03-09
Abstract: A coupling system includes a lower marine riser package having a connector at a bottom end and at least one blowout preventer pressure control element coupled to a wellhead and having a connector at an upper end. Explosively frangible fasteners are used to couple the connector on the lower marine riser package to the connector on the at least one blowout preventer pressure control element. A method for separating a lower marine riser package from a blowout preventer coupled to a subsea wellhead includes closing a least one pressure control element in the blowout preventer. At least one explosively frangible fastener coupling the blowout preventer to the lower marine riser package is detonated. The lower marine riser package is then lifted from the blowout preventer.
Patent CA-3057610-C (CA)
Title: Bumper beam
Inventor: KOGA ATSUO
IPC: B60R19/04
Filed: 2018-03-07
Granted: 2020-01-14
Abstract: A bumper beam 100 includes a closing plate 2 and a hat member 1.  The hat member 1 includes a top plate la, two flanges 1c, and two walls lb.  The hat member 1 includes a high-strength portion 10H and low-strength portions 10L. The high-strength portion 1011 includes a longitudinally middle portion of each of the two walls la and extends a length of at least 250 mm. The high-strength portion 10H has a tensile strength not lower than 1.5 GPa. The low-strength portions 10L are located outward of the high-strength portion and extends a length not smaller than the height of the walls. The low-strength portions have a tensile strength lower than the tensile strength of the longitudinally middle portion of the two walls.
Patent CA-3061623-C (CA)
Title: File sending in instant messaging applications
Inventor: ZHANG DONGYUAN
IPC: H04L51/04
Filed: 2017-12-05
Granted: 2023-09-19
Abstract: Provided are a file sending method in an instant messaging application and a corresponding client and server. According to an example of the file sending method, a client may obtain file information included in a session message edited on a session interface of an instant messaging application and obtain a candidate file according to the file information. The client may then present at least a portion of the candidate file and determine and send the file selected by a user according to a selection operation with the presented candidate file performed by the user. File sending efficiency in the instant messaging application can be effectively improved by automatically searching for the matched file according to the file information input by a user and displaying the same to the user for the user to select, without requiring the user to browse a file storage directory step by step.
Patent CA-3064971-C (CA)
Title: Wireless communication method and device
Inventor: ZHANG ZHI
IPC: H04W72/0453
Filed: 2017-06-16
Granted: 2023-10-17
Abstract: Provided is a wireless communication method and device. Frequency-domain resource allocation and/or bandwidth part configuration is flexibly performed on a terminal device in conjunction with a synchronous signal block, and the performance of a communication system can be raised. The method comprises: a network device receiving a first message sent by a terminal device, the first message being used for indicating a first synchronous signal block detected by the terminal device; and according to the first synchronous signal block, the network device performing frequency-domain resource allocation and/or bandwidth part configuration on the terminal device.