baber/WOPTO huggingface dataset:
Patent CA-3119632-A1 (CA)
Inventor: HAGEN WILLIAM
IPC: H01H9/26
Filed: 2019-11-14
Abstract: An improved mechanical interlock is disclosed. The mechanical interlock includes one or more features to facilitate a more robust design, easier assembly, and/or enhanced capabilities. For example, the mechanical interlock may include an interlock latch operatively associated with an external handle assembly and an internal connector. The interlock latch being directly coupled to a shaft coupled to the handle assembly, thus providing an improved and more robust latching mechanism. The mechanical interlock may also include one or more keys (e.g., a Poke-Yoke feature) to facilitate easier assembly and/or to prevent human errors caused by improper assembly. The mechanical interlock may also include an integrated magnetic switch and monitoring system to ensure that accurate location of the handle assembly is known.
Patent CA-3119801-A1 (CA)
Title: Vecteur de vhs a neurotoxicite reduite
Inventor: JIA WILLIAM
IPC: A61K31/76
Filed: 2019-11-29
Abstract: L'invention concerne des virus de l'herpès simplex de recombinaison ayant un génome de virus de l'herpès oncolytique modifié, le génome du virus de l'herpès modifié ayant au moins une séquence cible de miARN fonctionnellement liée à une première ou à une première et à une seconde copie d'un gène ICP34.5. L'invention concerne également des compositions pharmaceutiques ayant de tels virus de l'herpès simplex de recombinaison, ainsi que des procédés d'utilisation de telles compositions dans le traitement de sujets atteints d'un cancer.
Patent CA-3120292-A1 (CA)
Title: Shaft-sealing arrangement
Inventor: LEBIGRE OLIVIER
IPC: F16J15/3236
Filed: 2021-05-31
Abstract: The invention relates to a shaft-sealing arrangement (11) comprising a first seal and a second seal, wherein the first seal is designed in the form of a lip seal (5) and the second seal is designed in the form of a mechanical seal (25), wherein, when the shaft is at a standstill, the lip seal performs the sealing action and, when the shaft is rotating (operational state), the mechanical seal (25) performs the sealing action.
Patent CA-3121114-A1 (CA)
Inventor: UMBACH BRIAN
IPC: B62D55/15
Filed: 2019-11-20
Abstract: L'invention concerne un système de machine (20) comprenant un cadre de galet (22) et un ensemble galet (30) monté sur le cadre de galet (22). L'ensemble galet (30) comprend un premier et un second collier de serrage (50), positionnés sur un arbre porte-galet (32) et comprenant chacun une partie inférieure (52, 53) et une partie supérieure (54, 55) de collier. Des éléments de fixation (56, 60) fixent par serrage les parties inférieure (52, 53) et supérieure (54, 55) de collier contre l'arbre porte-galet pour former des joints statiques (58, 60). Les colliers de serrage (48, 50) peuvent être pourvus de lignes de séparation (72, 73) leur (48, 50) permettant de se déformer de façon à simuler des ajustements avec serrage avec l'arbre porte-galet (32).
Patent CA-3121866-A1 (CA)
Title: Reaction mixture suitable for manufacturing of foam with reduced aldehyde emission
Inventor: LUAN BAO
IPC: C08G18/67
Filed: 2018-12-21
Abstract: Disclosed is a reaction mixture for the manufacturing of a polyurethane foam, which mixture can be obtained by reacting a polyfunctional isocyanate with an isocyanate-reactive compound, in the presence of a scavenger and at least one catalyst; and curing such reaction mixture enables providing a foam with reduced aldehyde emissions particularly useful in means of transport, such as interior part of cars.
Patent CA-3124014-A1 (CA)
Inventor: KRUGLICK EZEKIEL
IPC: A23P30/10
Filed: 2018-12-18
Abstract: Techniques described include methods, systems, products, devices, and/or apparatuses related to food processing systems, related methods, and food items produced therewith. For example, the food processing system may be configured to fabricate food aggregates from multiple food elements. The food processing system includes a first press body and a second press body. The second press body is positioned and oriented opposite to the first press body and reconfigurable from a first configuration to a second, non-planar configuration. The second, non-planar configuration of the press body is different from the first configuration. At least one of the first or second press bodies is movable in a manner that decreases space between the first and second press bodies, to compress the food elements and form the food aggregate. A dispenser of the food elements is positioned and configured to dispense the food elements between the first and second press bodies.
Patent CA-3124951-A1 (CA)
Title: Modulators of pin1 activity and uses thereof
Inventor: LONDON NIR
IPC: A61K31/4178
Filed: 2020-01-09
Abstract: Disclosed herein are compounds comprising an electrophilic moiety and rigid moiety for use in modulating an activity of Pin1. The rigid moiety comprises at least one functional group that is capable of forming hydrogen bonds with hydrogen atoms, wherein the electrophilic moiety and the rigid moiety are arranged such that the electrophilic moiety is capable of covalently binding to the Cys 113 residue of Pin1, and the rigid moiety is capable of forming hydrogen bonds with the Gin 131 and His 157 residues of Pin1. Further disclosed are novel compounds having Formula Id: Wherein the dashed line, W, X, Y, Z, Ra-Rc, R1, R2, L1, L2 and n are as defined herein, and libraries comprising such compounds. Further disclosed are methods of identifying a compound capable of modulating an activity of Pin1, by screening a library of compounds.
Patent CA-3128044-A1 (CA)
Title: Enpp1 inhibitors and methods of modulating immune response
Inventor: LI LINGYIN
IPC: C07F9/38
Filed: 2020-01-30
Abstract: Compounds, compositions and methods are provided for the inhibition of ENPP1. Aspects of the subject methods include contacting a sample with an ENPP1 inhibitor compound to inhibit the cGAMP hydrolysis activity of ENPP1. In some cases, the ENPP1 inhibitor compound is cell impermeable. ENPP1 inhibitor compounds can act extracellularly to block the degradation of cGAMP. Also provided are pharmaceutical compositions and methods for treating cancer. Aspects of the methods include administering to a subject a therapeutically effective amount of an ENPP1 inhibitor to treat the subject for cancer. In certain cases, the cancer is a solid tumor cancer. Also provided are methods of administering radiation therapy to a subject in conjunction with administering an ENPP1 inhibitor to the subject. The radiation therapy can be administered in the subject methods at a dosage and/or frequency effective to reduce radiation damage to the subject, but still instigate an immune response.
Patent CA-3132517-A1 (CA)
Inventor: KAMEN DEAN
IPC: A61M5/172
Filed: 2009-09-15
Abstract: A system for at least partial closed-loop control of a medical condition and method for monitoring the integrity of an analyte sensor is disclosed. The system includes at least one medical fluid pump, at least one continuous analyte monitor comprising an analyte sensor, and a controller. The controller is in communication with the medical fluid pump and the at least one continuous analyte monitor. The controller includes a processor configured to detect whether the continuous analyte sensor is providing unexpected information and, when detected, prompts a user to inject a volume of an analyte having a predetermined concentration in close proximity to the continuous analyte sensor for the analyte. The data received following injection is analyzed by the processor to determine whether the continuous analyte sensor has failed or is providing incorrect or inaccurate information.
Patent CA-3134809-A1 (CA)
Title: Dispositif de camera de surveillance
Inventor: SEKIYA HIROSHI
IPC: G03B17/56
Filed: 2020-03-18
Abstract: Le problème décrit par la présente invention est de fournir un dispositif de caméra de surveillance qui est capable d'effectuer une imagerie stable dans des conditions de température élevée. À cet effet, l'invention concerne un dispositif de caméra de surveillance A servant à surveiller un dispositif dans des conditions de température élevée et comprenant : une caméra de surveillance 1 ; un boîtier 3 à l'intérieur duquel est logée la caméra de surveillance 1 ; et un tube d'air de refroidissement 8 servant à guider de l'air à l'intérieur du boîtier 3. Le boîtier 3 possède un corps principal 31 cylindrique et un couvercle arrière 7 fixé à l'extrémité arrière du corps principal 31. Le tube d'air de refroidissement 8 est fixé au couvercle arrière 7.
Patent CA-3135778-A1 (CA)
Title: Mushroom casing mix
Inventor: JEONG KA YEON
IPC: A01G18/00
Filed: 2021-10-25
Abstract: There is shown a mushroom casing mix having a core material of up to 100% sphagnum peat moss and a concentration mix of wollastonite and dolomitic limestone in a ratio of : 8.5 per 1 yard of core material. After adding the concentration mix to the core material, the mushroom casing mix is configured to have an enhanced ability to maintain a pH between 7.5 and 8.2 within 14 days after the concentration mix is added to the core material.
Patent CA-3136569-A1 (CA)
Title: Crystal polymorphism of pi3k inhibitor and method for preparing same
Inventor: KIM SEONG HEON
IPC: A61K31/519
Filed: 2020-05-08
Abstract: The present invention relates to a novel crystal polymorphism of a P13K inhibitor, and a method for preparing same. The novel crystal form of the present invention has remarkably superior non-hygroscopicity, can exhibit a superior pharmacological effect due to high blood levels, and exhibits high bioavailability, and thus is suitable for pharmaceutical formulations.
Patent CA-3137715-A1 (CA)
Inventor: DARIMONT BEATRICE DIANA
IPC: C12N15/113
Filed: 2020-04-24
Abstract: L'invention concerne des conjugués d'oligonucléotides et des compositions pharmaceutiques permettant d'induire un saut multi-exon. Dans certains cas, l'invention concerne également des méthodes de traitement d'une dystrophie musculaire, notamment de traitement de la dystrophie musculaire de Duchenne ou de la dystrophie musculaire de Becker.
Patent CA-3137917-A1 (CA)
Title: Wide angle spray nozzle
Inventor: ARENSON MARC A
IPC: B05B1/04
Filed: 2020-05-08
Abstract: A spray nozzle (10) with first and second discharge orifices (44, 46) are provided in the dome-shaped end wall (42) with each of the first and second discharge orifices being arranged on a respective one of opposing sides of an apex of the dome-shaped end wall. The first and second discharge orifices are configured to produce a fan-shaped fluid discharge pattern with each discharge orifice (44, 46) having an elongated slit-like configuration.
Patent CA-3139901-A1 (CA)
Title: Method for selecting a patient for a reperfusion therapy
Inventor: MONTANER VILLALONGA JOAN
IPC: G01N33/68
Filed: 2020-05-15
Abstract: The invention relates to a method for selecting a patient suffering stroke for a reperfusion therapy based on determining the level of retinol binding protein-4 (RBP4) and N-terminal fragment of B-type natriuretic peptide (NT-proBNP) in an isolated sample of said patient. The invention also relates to a method of differentiating ischemic stroke from haemorrhagic stroke and to kits comprising reagents to carry out the methods.
Patent CA-3140010-A1 (CA)
Inventor: CHEN QINGSONG
IPC: H04L27/26
Filed: 2020-08-03
Abstract: The present invention relates to a method, device and apparatus for time division duplex synchronization for a distributed antenna system, and a medium. The method comprises: decoding an SS/PBCH block from a time division duplex cell, and obtaining an index of the SS/PBCH block; determining, according to the index of the SS/PBCH block, a starting position of a radio frame in which the SS/PBCH block is located; and performing time division duplex synchronization according to the starting position of the radio frame and a preset uplink and downlink configuration of the radio frame. The solution of the present invention solves the problem in the art in which performing time division duplex synchronization by means of a GPS results in an increase in deployment costs of a distributed antenna system, thereby reducing deployment costs of a distributed antenna system.
Patent CA-3140351-A1 (CA)
Title: Adjustable tipping device for a refuse vehicle
Inventor: MORTENSON MATTHEW
IPC: B65F3/04
Filed: 2021-11-24
Abstract: A refuse container tipping device includes a first mounting plate, a second mounting plate, a hinge plate, and a plurality of fasteners. The first mounting plate defines a plurality of first slots. The plurality of first slots each extend in a first direction along substantially parallel axes. The second mounting plate is releasably coupled to the first mounting plate and defines a plurality of second slots. The plurality of second slots each extend in a second direction along substantially parallel axes. The first direction is perpendicular to the second direction. The hinge plate is coupled to the second mounting plate. The hinge plate supports a hinge and a grapple arm that is rotatably coupled to the hinge. The plurality of fasteners couple the second mounting plate to the first mounting plate by extending through the plurality of first slots and the plurality of second slots.
Patent CA-3140977-A1 (CA)
Title: Drilling system and method using calibrated pressure losses
Inventor: BRANA JOSE
IPC: E21B44/00
Filed: 2020-03-30
Abstract: Control of a drilling system drilling a wellbore is improved using a hydraulic model corrected for pressure losses. A surface backpressure of the outlet and a standpipe pressure of the inlet are measured with sensors in the system. An estimate of the standpipe pressure is calculated based integrating from the measured surface backpressure back to the inlet in the hydraulics model. The pressure loss increment in the hydraulics model is calculated based on a difference between the measured and estimated standpipe pressures. Meanwhile, a parameter in the drilling system is monitored during drilling so the parameter can be adjusted at least partially based on the hydraulics model corrected for the pressure loss.
Patent CA-3141017-A1 (CA)
Inventor: MEYER KATHRIN CHRISTINE
IPC: A61K48/00
Filed: 2020-04-15
Abstract: The present disclosure relates to methods of targeting specific cell types within the retina using optimized gene therapy vectors in combination with a glycoside hydrolase enzyme, such as neuraminidase. In particular, the disclosure provides gene therapy vectors administered with a glycoside hydrolase enzyme to specifically target retinal cells and methods of treating visual impairment, retinal degeneration and vision-related disorders.
Patent CA-3141693-A1 (CA)
Title: Shape memory material for controlled liquid delivery in an aerosol delivery device
Inventor: HEJAZI VAHID
IPC: A24F40/485
Filed: 2020-05-20
Abstract: The present disclosure provides an aerosol delivery device and a cartridge for an aerosol delivery device. In various implementations, the cartridge (104) may comprise a housing defining a liquid reservoir (144), an atomizer (115) configured to produce an aerosol, the atomizer comprising a first liquid transport element 136, a second liquid transport element 182, and a microvalve 180 located between the liquid reservoir and the second liquid transport element. The microvalve may comprise a base member 181 including at least one channel (192A-B), and an actuating member 185A-B at least a portion of which comprises a shape-memory material, and which is configured to move between a first position and a second position, wherein in the first position, the actuating member substantially blocks fluid flow from the liquid reservoir through the channel, and in the second position, the actuating member allows fluid flow from the liquid reservoir through the channel and to the second liquid transport element.
Patent CA-3142215-A1 (CA)
Title: Method for charging a container for use with a medication delivery apparatus, container for such an apparatus and method for treating a patient
Inventor: CORR STUART
IPC: B65B31/04
Filed: 2020-06-08
Abstract: A method of charging a container for use in a medication delivery apparatus wherein the propellant used comprises 1,1-difluoroethane (R-152a) is described.
Patent CA-3143652-A1 (CA)
Inventor: COLEMAN JACK
IPC: C12Q1/6876
Filed: 2012-02-28
Abstract: Provided are compounds comprising two DNA supramolecular binding molecules covalently joined by a linker group. Also provided are multisignal labeling reagents comprising (i) an oligomer of nucleotides or nucleotide analogs; (ii) a DNA  supramolecular binding molecule noncovalently bound to the oligomer; and (iii) a first reactive group or a first partner of a first binding pair covalently bound to the oligomer. Additionally provided are methods of producing multisignal labeling reagents.
Patent CA-3145200-A1 (CA)
Inventor: OKIYAMA syou
IPC: A61K31/351
Filed: 2020-06-30
Abstract: Le problème décrit par la présente invention est d'améliorer l'efficacité thérapeutique contre les infections par le virus de la grippe. La solution selon l'invention porte sur une composition pharmaceutique pour traiter des infections par le virus de la grippe qui contient un agent anti-virus de la grippe en tant que principe actif, la composition pharmaceutique étant caractérisée en ce que l'agent anti-virus de la grippe est administré à un patient qui a été déterminé comme étant positif à une infection par le virus de la grippe au moyen d'une image intrabuccale prise à l'aide d'un dispositif d'imagerie intrabuccal.
Patent CA-3150886-A1 (CA)
Title: Anti-pd-l1 single-domain antibody and derivatives and use thereof
Inventor: XU YIFENG
IPC: C07K16/28
Filed: 2020-09-07
Abstract: Provided is a complementary determining region (CDR) of a VHH chain of an anti-PD-Ll single-domain antibody, wherein the CDR of the VHH chain includes the following: CDR1 with an amino acid sequence as shown in SEQ ID NO:5n+l; CDR2 with an amino acid sequence as shown in SEQ ID NO:5n+2, or CDR2 with an amino acid sequence having an sequence identity of greater than 85% with a sequence as shown in SEQ ID NO:2; and CDR3 with an amino acid sequence as shown in SEQ ID NO: 5n+3; wherein, each n is independently 0,1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15.
Patent CA-3151515-A1 (CA)
Inventor: SAMPSON KATHLEEN
IPC: C08J5/12
Filed: 2020-08-26
Abstract: La présente invention concerne des produits fonctionnels et/ou précurseurs fonctionnels, des formulations pour fabriquer les produits, des procédés de fabrication des produits (par exemple des revêtements fonctionnels, des gradients concentrés et/ou des composites) et leurs utilisations. Selon un aspect, le procédé comprend : a) la combinaison d'au moins un premier composant polymérisable et d'au moins un second composant polymérisable pour former une composition ; et b) la polymérisation du ou des premiers composants polymérisables pour former au moins une première structure polymère, au moins deux phases étant formées à partir de la ou des premières structures polymères et du ou des seconds composants polymérisables, et le produit étant un produit fonctionnel, un produit précurseur fonctionnel ou une combinaison d'un produit fonctionnel et précurseur fonctionnel.
Patent CA-3152535-A1 (CA)
Title: Amplification par la polymerase a l'echelle nanometrique: procedes et dispositifs pour l'amplification et la detection d'acides nucleiques
Inventor: GOEL ANITA
IPC: C12Q1/686
Filed: 2005-05-13
Abstract: Des méthodes, des dispositifs, et des compositions sont décrits pour lamplification de séquences dacides nucléiques indépendamment du cycle de température, ce qui permet ainsi lélimination de dispositifs de cycle thermique de tables de laboratoire classiques. La dénaturation dacides nucléiques à double brin, le recuit damorces, et le contrôle de précision sur lextension damorces par la polymérase peuvent être réalisés par lapplication de contrainte à un acide nucléique. Ces méthodes peuvent procurer au moins un avantage par rapport aux procédés damplification en chaîne par polymérase (PCR) classiques, dont : le contrôle de la précision du procédé de PCR; une fidélité globalement améliorée; une précision améliorée des séquences problématiques, comme les régions à taux élevés de guanine-cytosine ou de répétition en tandem; une longueur de séquence rallongée; un rendement de réaction accru; un temps expérimental réduit; une meilleure efficacité; un coût réduit; une grande portabilité; et une robustesse contre divers paramètres environnementaux, comme la température, le pH, et les forces ioniques.
Patent CA-3153115-A1 (CA)
Inventor: FLECK MARTIN THOMAS
IPC: C07D495/04
Filed: 2020-10-14
Abstract: The present application relates to thienopyrimidinones and their use as inhibitors of TRPA1 activity, pharmaceutical compositions comprising the same and methods of using the same as agents for treatment and/or prevention of fibrotic diseases, inflammatory and auto-immune diseases and CNS-related diseases.
Patent CA-3154163-A1 (CA)
Inventor: ACHARYA ANANTA
IPC: C12Q1/6855
Filed: 2020-10-09
Abstract: The disclosed embodiments concern methods for determining sequences of interest using targeted unique molecular index (TUMI) sequences that are uniquely associated with individual polynucleotide fragments in plants, such as those present in a transgenic event, a site-specific mutation or a wild type variant. System, apparatus, and computer program products are also provided for determining a sequence of interest implementing the methods disclosed.
Patent CA-3154720-A1 (CA)
Title: Composes lipidiques a tetes polaires et compositions pour administration intracellulaire d'agents therapeutiques
Inventor: BENENATO KERRY E
IPC: C07D305/08
Filed: 2020-09-18
Abstract: La présente invention concerne des lipides de formule (A-1) et des compositions les comprenant. Les nanoparticules lipidiques (par exemple, les LNP vides ou les LNP chargées) comprennent de tel lipide ainsi que des lipides supplémentaires, tels que des phospholipides, des lipides structuraux, et des lipides PEG. Les nanoparticules lipidiques (par exemple, les LNP vides ou les LNP chargées) comprenant en outre des agents thérapeutiques et/ou prophylactiques tels que de l'ARN sont utiles dans l'administration d'agents thérapeutiques et/ou prophylactiques à des cellules ou des organes de mammifère pour, par exemple, réguler l'expression de polypeptides, de protéines, ou de gènes.
Patent CA-3159463-A1 (CA)
Title: Alumine presentant un profil poreux particulier
Inventor: HERNANDEZ JULIEN
IPC: B01J35/02
Filed: 2020-11-25
Abstract: La présente invention est relative à une alumine présentant un profil poreux particulier et une bonne stabilité thermique. Cette alumine se caractérise également par le fait qu'elle présente une densité apparente élevée. L'alumine présente après calcination sous air à 1100°C pendant 5 heures : - un volume poreux dans le domaine des pores dont la taille est comprise entre 5 nm et 100 nm qui est compris entre 0,50 et 0,75 mL/g, plus particulièrement entre 0,50 et 0,70 mL/g; et - un volume poreux dans le domaine des pores dont la taille est comprise entre 100 nm et 1000 nm qui est inférieur ou égal à 0,20 mL/g, plus particulièrement inférieur ou égal à 0,15 mL/g, voire inférieur ou égal à 0,10 mL/g.
Patent CA-3160983-A1 (CA)
Title: Hockey stick blade cover
Inventor: EASTMAN MATTHEW
IPC: A63B60/56
Filed: 2022-05-30
Abstract: A hockey stick blade cover for protecting a blade of a hockey stick therein from damage during hockey play over ice and/or non-ice playing surfaces comprising an elongated sheath having a wear indicator, a toe end and a heel end; a first sidewall; a second sidewall; and a plurality of generally v-shaped cut sections; wherein the first side wall and the second side wall are configured to compress and hold a blade of a hockey stick therebetween.