baber/WOPTO huggingface dataset:
Patent WO-2019241707-A1 (WO)
Title: Compositions and methods for preventing or reversing t-cell exhaustion through ectonucleotidase inhibition antibody-mediated target cytosis
Inventor: ROBSON SIMON
IPC: C07K16/28
Filed: 2019-06-14
Abstract: In combination with conventional therapies (e.g., targeted therapy, chemotherapy, and angiogenesis inhibitors etc.), immunotherapies targeting checkpoint molecules have shown promise in the treatment of solid or liquid tumors. However, apoptotic regulatory T cells (Treg) induced by such therapies often become more suppressive in the tumor microenvironment (TME), through increased generation of adenosine tightly controlled by ectonucleotidases, viz. CD39 and CD73. CD39/ENTPD1, a novel checkpoint molecule, is highly expressed and activated on the tumor vasculature and infiltrating immune cells, promoting tumor growth. Deletion or blockade of CD39 enhances anti-tumor activity by augmenting anti-tumor immune responses and inhibiting tumor angiogenesis. The present invention is based at least in part on the development of anti-CD39 antibodies which mediate CD39 downregulation on immune cells, such as T-cells with markers of T-cell exhaustion, and the demonstrated utility of these antibodies in blocking tumor growth with minimal side effects in pre-clinical models.
Patent WO-2020256724-A1 (WO)
Inventor: BUGH ROBERT
IPC: G06F17/00
Filed: 2019-06-19
Abstract: The bingo-style game process uses electronic game cards (21) with a 5x5 matrix of squares pre-populated with a defined result derived from the key element of a live sporting event (FIG.6). The key element supplies defined results one at a time from a set of defined results for comparison to the current single square, in play, designated the subject square(53). A match of the defined result supplied by the key element with the pre-populated defined result in the subject square creates a marked square (25). The next sequential square becomes the subject square (53) for comparison to the next defined result supplied by the key element. The sequential process is repeated, through the squares, an indefinite number of times. A group of marks creating a pre-determined winning pattern (29) is a winner of the game. The game continues until the event containing the key element concludes or a game winner is announced.
Patent WO-2019246517-A1 (WO)
Title: Décoration de surface entière de tubes moulés par soufflage
Inventor: MCKILLIP BARRON
IPC: B29C37/04
Filed: 2019-06-21
Abstract: L'invention concerne un procédé de production d'un tube (36), comprenant la formation d'un article moulé par soufflage et l'élimination d'une partie inférieure dudit article moulé par soufflage. L'article moulé par soufflage comprend (i) une partie tête (64), et (ii) une partie tube (66) solidaire de ladite partie tête. Le tube peut être décoré, par exemple avec une étiquette (72).
Patent WO-2020006060-A1 (WO)
Inventor: CERAFOGLI CHIARA
IPC: G11C29/02
Filed: 2019-06-26
Abstract: L'invention concerne des dispositifs et des techniques d'opérations sensibles à la température NON-ET. Un dispositif de commande de dispositif peut recevoir une commande pour écrire des données sur un composant dans le dispositif. Une température correspondant au composant peut être obtenue en réponse à la réception de la commande. La commande peut être exécutée par le dispositif de commande pour écrire des données sur le composant. L'exécution de la commande peut comprendre l'écriture de la température dans une partie de gestion du dispositif qui est séparée d'une partie utilisateur du dispositif sur lequel les données sont écrites.
Patent WO-2020033936-A1 (WO)
Title: Code block mapping in wideband transmissions for new radio (nr) systems operating in unlicensed spectrum
Inventor: TALARICO SALVATORE
IPC: H04L5/00
Filed: 2019-08-10
Abstract: Embodiments described herein relate to mapping methodologies and mechanisms. More specifically, embodiments described herein provide multiple options for efficiently mapping resources for a code block when a NR system operates in NR-U. In one example, a code block (CB) may be mapped as in LTE by spanning over the time domain resources first and then the frequency domain resources. In this way, independently of the failure of one or more of the 20 MHz units over which the wideband transmission is performed, the part of the CB that is transmitted, corresponding to the frequency/time resources for which the LBT has succeeded, is decodable.
Patent WO-2020047002-A1 (WO)
Inventor: SCHNALL-LEVIN MICHAEL
IPC: C12Q1/6837
Filed: 2019-08-27
Abstract: The present disclosure relates to materials and methods for spatially analyzing nucleic acids that have been fragmented with a transposase enzyme, alone or in combination with other types of analytes
Patent WO-2020056410-A1 (WO)
Inventor: BEIER ULF
IPC: A61P37/06
Filed: 2019-09-16
Abstract: La présente invention concerne des méthodes pour moduler l'immunosuppression. La présente invention concerne les domaines de la régulation des lymphocytes T et de l'immunosuppression thérapeutique. Plus spécifiquement, l'invention concerne des compositions et des méthodes destinées à des thérapies immunosuppressives sélectives pour le traitement de maladies auto-immunes et de receveurs d'allogreffe.
Patent WO-2020081244-A1 (WO)
Title: Command block management
Inventor: BOEHM AARON
IPC: G06F3/06
Filed: 2019-10-03
Abstract: Methods, systems, and devices for command block management are described. A memory device may receive a command (e.g., from a host device). The memory device may determine whether the command is defined by determining if the command is included within a set of defined commands. In the case that a received command is absent from the set of defined commands (e.g., the command is undefined), the memory device may block the command from being decoded for execution by the memory device. In some cases, the memory device may switch from a first operation mode to a second operation mode based on receiving an undefined command. The second operation mode may restrict an operation of the memory device, while the first mode may be less restrictive, in some cases. Additionally or alternatively, the memory device may indicate the undefined command to another device (e.g., the host device).
Patent WO-2020097002-A1 (WO)
Title: Gènes fig4 optimisés et cassettes d'expression et leur utilisation
Inventor: GRAY STEVEN JAMES
IPC: C12N15/86
Filed: 2019-11-05
Abstract: La présente invention concerne des polynucléotides comprenant des séquences de cadres de lecture ouverts (ORF) FIG4 optimisés, des vecteurs les comprenant, et des procédés d'utilisation de ceux-ci pour l'administration des ORF à une cellule ou à un sujet et pour traiter des troubles associés à une expression aberrante d'un gène FIG4 ou d'une activité aberrante d'un produit génique FIG4 chez le sujet, tel que CMT4J.
Patent WO-2020097007-A1 (WO)
Inventor: BROCHMAN TODD
IPC: B21D7/08
Filed: 2019-11-05
Abstract: A portable tubing bender configured to automatically bend a portion of tubing according to a defined set of bend specifications, including a desired number of bends and a desired angle for each bend. The portable tubing bender including a driver configured to rotate a driven shaft and a first rotational output, a reductive gear set operably coupling the driven shaft to an output shaft, a bender shoe couplable to the output shaft, the bender shoe defining an arcuate channel configured to receive tubing during bending operations, and an automatic feed mechanism configured to advance the tubing relative to the bender shoe from an initial position to a bend position.
Patent WO-2020097344-A1 (WO)
Title: Immunomodulation synthétique avec un super-répresseur de crispr in vivo
Inventor: KIANI SAMIRA
IPC: C12N15/90
Filed: 2019-11-07
Abstract: L'invention concerne des systèmes de répression synthétique à base de CRISPR, ainsi que des procédés et des compositions utilisant les systèmes de répression synthétique pour traiter la septicémie, une réponse immunitaire indésirable chez un sujet et une macroglobulinémie de Waldenström.
Patent WO-2020113217-A1 (WO)
Inventor: VAN DEN HOONAARD PAUL
IPC: B65D75/58
Filed: 2019-12-02
Abstract: A spouted pouch (100) has a pouch (105) and a spout (110) and holds a viscous product (115), formed from a flexible pouch material (120). The spouted pouch includes a first (125) and second end (130), with a gusset (135) being disposed at the second end of the pouch. The spout is disposed at the first end of the pouch and has a sealboat that extends into the pouch according to a length of the sealboat and forming a seal that seals the viscous product within the spouted pouch. A stability of the spouted pouch is a function of the length of the sealboat extension into the pouch, a depth of the gusset, dimensions of the sealboat, and a width of the pouch, such that the spouted pouch is stable both standing in a downside-up orientation in which the gusset contacts a support surface and standing in an upside-down orientation in which the sealboat contacts the support surface.
Patent WO-2020131378-A1 (WO)
Title: Mold with volume compensation for spoke of non-pneumatic tire
Inventor: WILSON BRIAN D
IPC: B29D30/02
Filed: 2019-12-04
Abstract: A mold 810) for manufacturing a spoke for a non-pneumatic tire is provided that has first and second mold pieces (16, 22) with first and second engagement surfaces to engage the spoke. The first mold piece (16) has a void (20), and is movable relative to the second mold piece. A volume compensation feature (26) is carried by the first mold piece (16) and has a base that is located at the void. The volume compensation feature has a deflection plate (30) that engages the base, and has a non-deflected orientation and a deflected orientation. When the mold is closed the spoke engages the deflection plate and deflects the deflection plate relative to the first engagement surface so as to be in the deflected orientation.
Patent WO-2020171876-A1 (WO)
Title: Module de siège de véhicule avec non-tissé et attache en j extrudés
Inventor: ROBINSON EMILY
IPC: B60N2/60
Filed: 2019-12-05
Abstract: Dans un exemple, un siège de véhicule comprend un non-tissé et une attache en J, le non-tissé étant fixé à l'attache en J pour définir un seul composant. Le siège de véhicule comprend un revêtement de garniture fixé au non-tissé, et l'attache en J est fixée à une armature de coussin pour fixer le revêtement de garniture à l'armature de coussin.
Patent WO-2020131621-A1 (WO)
Inventor: STEFFENHAGEN TIMOTHY SCOTT
IPC: E21B19/22
Filed: 2019-12-13
Abstract: La présente invention concerne un système d'injecteur à tube spiralé comprenant un système de traction destiné à faire avancer un tube spiralé à travers l'injecteur et dans ou hors d'un puits. Le système de traction comprend une pluralité de supports (129) et de patins d'ancrage (128) conçus pour se propager de manière répétée à travers l'injecteur le long de guides (114). Le système de traction comprend également un dispositif de surveillance de position (134) destiné à surveiller la position latérale du support, du patin d'ancrage ou de la portion de celui-ci lorsque le support et le patin d'ancrage se propagent le long du trajet de tube spiralé.
Patent WO-2020146880-A1 (WO)
Inventor: ALIZAD AZRA
IPC: A61B8/08
Filed: 2020-01-13
Abstract: L'invention concerne des systèmes et des procédés pour générer des images de microvaisseaux à partir de données d'images acquises avec un système ultrasonore tout en analysant les données d'images en temps réel, ou rétrospectivement, pour générer un descripteur de performances qui peut être utilisé pour évaluer la qualité de données et/ou la qualité de correction de mouvement ; pour supprimer de manière adaptative le bruit dans les données ; ou les deux.
Patent WO-2020150264-A1 (WO)
Inventor: LIU FENG
IPC: G06T3/00
Filed: 2020-01-14
Abstract: L'invention concerne des procédés, des systèmes, et des supports de stockage pour une estimation de mouvement dans une interpolation de trame vidéo. Des modes de réalisation de l'invention utilisent des pyramides de caractéristiques en tant que représentations d'image pour une estimation de mouvement, et les intègrent en continu dans un réseau neuronal profond pour une interpolation de trame. Une pyramide de caractéristiques est extraite pour chacune de deux trames d'entrée. Ces pyramides de caractéristiques sont combinées aux trames d'entrée à la position temporelle cible d'après le mouvement inter-trame estimé par l'intermédiaire d'un flux optique. Un réseau de synthèse de trame est utilisé pour prédire des résultats d'interpolation à partir des pyramides de caractéristiques/trames d'entrée combinées. L'extracteur de pyramide de caractéristiques et le réseau de synthèse de trame sont entraînés conjointement pour exécuter la tâche d'interpolation de trame. Une évaluation quantitative et qualitative approfondie démontre que les modes de réalisation décrits utilisant des pyramides de caractéristiques permettent une interpolation de trame vidéo robuste et de haute qualité. D'autres modes de réalisation peuvent être décrits et/ou revendiqués.
Patent WO-2020154718-A1 (WO)
Inventor: AVGERINOS PAUL
IPC: E05C7/02
Filed: 2020-01-27
Abstract: La présente invention concerne un procédé donné à titre d'exemple qui consiste à placer un premier adhésif sur une première surface d'une gâche, la gâche comprenant une poche s'étendant dans une seconde surface de la gâche à l'opposé de la première surface de la gâche. Le procédé consiste également à placer un second adhésif sur une première surface d'un module de verrouillage, le module de verrouillage comprenant un boulon pouvant être actionné pour s'étendre au-delà d'une seconde surface du module de verrouillage. Le procédé consiste en outre à aligner la poche avec le boulon de telle sorte que le boulon peut être utilisé pour s'étendre dans la poche ; et la poche et le boulon étant alignés l'un avec l'autre, joignant de manière libérable la gâche et le module de verrouillage avec un coupleur libérable, formant ainsi un ensemble de verrouillage aligné.
Patent WO-2020159880-A1 (WO)
Inventor: WANG SHUSHENG
IPC: A61K45/06
Filed: 2020-01-27
Abstract: The present disclosure provides CRISPR-based compositions and methods of their use to impair or promote angiogenesis in a patient to treat indications including, but not limited to, tumor growth, age-related macular degeneration, and metastasis.
Patent WO-2020180807-A1 (WO)
Title: Multi-socket server assembly
Inventor: THAKAR ANANT
IPC: H05K7/20
Filed: 2020-03-02
Abstract: In some examples, a printed circuit board assembly can include a printed circuit board having four (4) central processor unit (CPU) sockets disposed thereon and sixty four (64) dual in-line memory modules (DIMMs) disposed thereon. The printed circuit board can have a top surface and a bottom surface with two (2) CPU sockets and thirty two (32) DIMMs disposed on the top surface and two (2) CPU sockets and thirty two (32) DIMMs disposed on the bottom surface.
Patent WO-2020197941-A1 (WO)
Title: Dynamically modifying transportation requests for a transportation matching system using surplus metrics
Inventor: ABELENDA JOSE
IPC: G01C21/34
Filed: 2020-03-19
Abstract: This disclosure covers computer-implemented methods, non-transitory computer readable media, and systems that utilize surplus metrics for transportation requests to generate modifiers for the transportation requests. For example, the disclosed systems determine a response time period and a service time period for a transportation request to determine the amount of time and movement distance associated with transportation provider device during the transportation request. Additionally, the disclosed systems determine a surplus metric for the transportation request based on the response time period and the service time period. In response to determining that the surplus metric does not meet a predetermined threshold, the disclosed systems generate a modifier to apply to the transportation request based on the surplus metric. Additionally, the disclosed systems provide a message to the transportation provider device indicating the modifier applied to the transportation request.
Patent WO-2020191273-A1 (WO)
Title: Fast equalization for jitter mitigation
Inventor: AZENKOT YEHUDA
IPC: H04L25/10
Filed: 2020-03-20
Abstract: A system for receiving signals transmitted via serial links includes an equalizer for accessing a digitized communications signal and producing an equalized output signal, and a fast equalization module for determining output data corresponding to the communications signal The fast equalization module includes a filter to access an output of the equalizer, a sheer module to access an output, of the filter and produce a data output corresponding to the communications signal, a lookup table to provide filtering coefficients to the filter, and a coefficient, improvement module to improve the coefficients based on an error signal, from the filer. The coefficient improvement module is configured to update the coefficients in. the lookup table.
Patent WO-2020198679-A1 (WO)
Inventor: BEARDSLEE THOMAS A
IPC: C12P7/42
Filed: 2020-03-27
Abstract: The invention provides engineered biosynthetic pathways that can be used to produce cannabinoids from fatty acids, recombinant microorganisms incorporating such pathways, methods of biosynthetically producing cannabinoids from fatty acids, and cannabinoids so produced.
Patent WO-2020205941-A1 (WO)
Inventor: KIPNIS MICHAEL
IPC: F01L3/20
Filed: 2020-04-01
Abstract: Poppet valve for an internal combustion engine including a valve stem and a single circular valve head attached at one end of the valve stem. The valve head has a circular peripheral contour and an arcuate edge without any sharp elements to avoid turbulence and improve flow around the valve to therefore maximize flow velocity. This translates into increased cylinder breathing in the intake cycle and reducing back pressure in the exhaust cycle.
Patent WO-2020210214-A1 (WO)
Title: Compositions and methods for modifying dystrophin genes
Inventor: SPENCER MELISSA J
IPC: C12N15/87
Filed: 2020-04-07
Abstract: Disclosed herein are guide sequences for modifying a dystrophin gene using CRISPR technology. Specifically, the disclosure provides a method of modifying a dystrophin gene in a cell or a subject, which comprises introducing into the cell or subject (a) a Cas protein or a nucleotide sequence encoding the Cas protein; and a single guide RNA (gRNA), or a first gRNA and a second gRNA, wherein the Cas protein is a type II CRISPR/Cas endonuclease. Further disclosed are gRNA nucleic acid sequences.
Patent WO-2021216036-A1 (WO)
Inventor: ROGACS ANITA
IPC: G05D11/00
Filed: 2020-04-20
Abstract: Example implementations relate to fluid dispenser frequencies. For example, an apparatus can include a controller communicatively coupled to a droplet dispenser to deposit a fluid on a matrix, wherein the controller is to: deposit the fluid at a particular position on the matrix at a first frequency, determine an accumulation volume of the fluid at the particular position on the matrix, alter the first frequency to a second frequency based on the accumulation volume, and determine a speed of lateral flow of the fluid through the matrix utilizing the second frequency.
Patent WO-2020227183-A1 (WO)
Title: Lenalidomide prodrugs, polymeric conjugates, and formulations thereof, and their uses for the treatment of multiple myeloma
Inventor: PATEL DEVEN
IPC: A61K31/44
Filed: 2020-05-03
Abstract: Compounds of formula I and II:, I II or a pharmaceutically acceptable salt thereof, and their compositions including polymer encapsulated micro/nano particle compositions are provided, wherein: R 1  is -CH 2 -, a C 2-6  straight or branched chain alkylene, alkenylene or alkynylene group or a short chain polyethylene glycol group having 2-6 monomers, or a combination thereof; R 2  is hydrogen or –(C=O)R 3  wherein R 3  is a C2-6 straight or branched chain alkylene, alkenylene or alkynylene group or a short chain polyethylene glycol group having 2-6 monomers, or a combination thereof; and R 4  is a pharmaceutically acceptable polymeric moiety comprising a pharmaceutically acceptable polymer chain such that R 1  is linked to the polymer chain through an ester, carbonate or carbamate bond including the oxygen atom linking R 1  and R 4 . The compositions are useful for treatment of multiple myeloma, mantle cell lymphoma, and transfusion-dependent anemia due to myelodysplastic syndromes.
Patent WO-2020256846-A1 (WO)
Inventor: TIAN JUNZHUO
IPC: H02J7/34
Filed: 2020-05-06
Abstract: Mitigation of audible output of one or more components in a charging circuit. A charging circuit may include a mitigation controller operative to monitor a frequency of voltage at an input of a charging circuit. The frequency of the voltage at the input node may result in a mitigation condition associated with audible output of one or more components of the charging circuit. In response to detection of the mitigation condition, the mitigation controller may temporarily disable the supply of power from charging circuit to a system load to mitigate (e.g., potentially eliminate) audible output of the circuit. During a time in which the charging circuit is disabled from supplying power to the system load, a battery of the device may supply power to the system load.
Patent WO-2020227354-A1 (WO)
Inventor: R DEEPAK
IPC: G06F9/52
Filed: 2020-05-06
Abstract: Methods and systems for file locking are described herein. An on-premise file share may store files that are accessible to both a local on-premise client and a remote off-premise client. The off-premise file share may request to check-out one of the files. In response, one of multiple nodes may obtain for the file a file handle with exclusive write access. File locking information may be stored at the file share that indicates the node that holds the file handle and that indicates the file is in a locked state whereby other remote off-premise clients or local on-premise clients are prevented from editing the file.
Patent WO-2020232039-A1 (WO)
Inventor: HEVNER JANETTE
IPC: C03C3/083
Filed: 2020-05-13
Abstract: A method of modifying a substrate comprising an etching step comprising contacting one or more primary surfaces of a glass, glass-ceramic, or ceramic substrate with a solution for a time period of 20 minutes to 8 hours to generate one or more etched primary surfaces, the solution comprising over 10 percent by weight of one or more alkali hydroxides, the solution having a temperature within the range of 100 °C to 150 °C, the substrate having a thickness between the primary surfaces that decreases during the time period by 5 µm to 100 µm at a rate of 2 µm per hour or greater. The solution of the etching step does not comprise hydrogen fluoride. The one or more alkali hydroxides of the solution of the etching step can be sodium hydroxide (NaOH), potassium hydroxide (KOH), or a combination of both sodium hydroxide and potassium hydroxide.
Patent WO-2020232421-A1 (WO)
Title: Low-power person tracking system that uses magnetic signals
Inventor: MCCLUSKEY CORY
IPC: G07C9/28
Filed: 2020-05-16
Abstract: A passenger tracking system that combines fobs carried by passengers and a passenger detector that detects when a fob is nearby. The fobs are battery powered and consume very little power; therefore, they can be sealed and waterproof, and may last for years before replacement. A fob is asleep until awakened by a short-range magnetic field broadcast by the passenger detector. After awakening, the fob listens for an encrypted message from the passenger detector, and responds with an encrypted response that contains the fob's identity. Tracking is secure because a fob is completely invisible unless and until it receives a magnetic field of the correct frequency and time-varying pattern, and an encrypted request message from an authorized sender; responses are also encrypted so that listeners cannot discover the fob's identity. The system is suitable for example for tracking schoolchildren entering or exiting a school bus.