baber/WOPTO huggingface dataset:
Patent ES-2257231-T1 (ES)
Inventor: TORGERSEN ULF
IPC: C08J5/18
Filed: 2003-11-17
Abstract: The invention relates to a flat film for thermoforming with high toughness, high stiffness and high transparency, comprising a polyolefin composition, which polyolefin composition comprises: A) a heterophasic propylene copolymer containing a) 75 - 95 wt% of a matrix phase comprising a propylene homopolymer or a propylene copolymer with up to 5 mol% of ethylene and/or at least one C4-C8 alpha-olefin and b) 5 - 25 wt% of a disperse phase comprising an ethylene rubber copolymer with from 20 - 80 mol% ethylene and from 80 - 20 mol% of at least one C3-C8 alpha-olefin and where the intrinsic viscosity of the XCS-fraction of the heterophasic copolymer is <= 2 dl/g and B) an alpha-nucleating agent and a process for their preparation and their use.
Patent ES-2030374-T1 (ES)
Title: Material catalizador y metodo de descomponer clorofluorocarbonos.
IPC: B01J23/75
Filed: 1991-09-13
Abstract: LA INVENCION PRESENTA UN MATERIAL CATALIZADOR Y UN METODO PARA LA DESCOMPOSICION DE CLOROFLUOROCARBUROS EN ACIDO FLUORHIDRICO, ACIDO CLORHIDRICO Y DIOXIDO DE CARBONO MEDIANTE LA REACCION CON AGUA. EL MATERIAL CATALIZADOR CONSISTE EN UN METAL SELECCIONADO DEL GRUPO QUE CONSISTE EN TI, ZR Y NB, O UNA ALEACION QUE CONSISTE EN DOS ELEMENTOS POR LO MENOS SELECCIONADOS DEL MISMO GRUPO. EL MATERIAL CATALIZADOR PUEDE ESTAR COMPUESTO TAMBIEN DE UNA ALEACION QUE CONSISTE EN HASTA UN 80% DE UN ELEMENTO POR LO MENOS SELECCIONADO DEL GRUPO QUE CONSISTE EN NI Y CO Y EL EQUILIBRIO SUSTANCIAL DE POR LO MENOS UN ELEMENTO SELECCIONADO DEL GRUPO QUE CONSISTE EN TI, ZR Y NB. LOS MATERIALES CATALIZADORES METALICOS DE LA INVENCION TIENEN UNA ACTIVIDAD CATALITICA MUY ALTA PARA LA DESCOMPOSICION DE FLUOROCARBUROS A TEMPERATURAS RELATIVAMENTE BAJAS Y PUEDEN RETENER SU ALTA ACTIVIDAD DURANTE EL PROCESO DE DESCOMPOSICION, INCLUSO SI SON CONVERTIDOS EN FLUORUROS.
Patent CY-1110072-T1 (CY)
Inventor: BAUER SVEN
IPC: B65D17/50
Filed: 2009-12-09
Abstract: The lid for tins has a flange (22) which fits inside a ring around the lip of the tin and a vertical outer wall (18) with a curved top (20) which fits over its outer edge. The lid has a central aperture (24) which is covered by a membrane (14). This can move between two mirror image positions in which it is curved downwards or upwards. An independent claim is included for a method for making the lid.
Patent CY-1110130-T1 (CY)
Title: Παραγωγα μορφολινης για χρηση ως αγωνιστες ντοπαμινης στην θεραπευτικη αγωγη σεξουαλικης δυσλειτουργιας i.α.
Inventor: ALLERTON CHARLOTTE MOIRA NORFOR
IPC: C07D413/04
Filed: 2010-04-26
Abstract: Η παρούσα εφεύρεση παρέχει ενώσεις του τύπου (I), (la) και (lb):
Patent CY-1110217-T1 (CY)
Inventor: RIEDER MARC ALEXANDER
IPC: F17C9/02
Filed: 2010-07-05
Abstract: The present invention relates to a method for the regasification of liquefied natural gas, the method at least comprising the steps of: a) removing liquefied natural gas (10) from a storage tank (2) using a first pump unit (3); b) passing the removed liquefied natural gas (20) to and feeding it into a second pump unit (4) at an inlet pressure; c) increasing the pressure of the liquefied natural gas in the second pump unit (4) thereby obtaining pressurized liquefied natural gas (50); d) vaporizing the pressurized liquefied natural gas (50) thereby obtaining gaseous natural gas (60); wherein the second pump unit (4) discharges the pressurized liquefied natural gas (50) at a pre-selected pressure value, regardless of the inlet pressure at the second pump unit (4).
Patent CY-1110205-T1 (CY)
Title: Ανοσογονος συνθεση και μεθοδοι
Inventor: ELDRIDGE JOHN H
IPC: A61K39/205
Filed: 2010-07-15
Abstract: Μία μέθοδος επαγωγής μιας αντίγονο ειδικής απόκρισης σε ένα άτομο θηλαστικού περιλαμβάνει τα στάδια χορήγησης στο άτομο μιας αποτελεσματικής ποσότητας μιας πρώτης σύνθεσης που περιλαμβάνει ένα DNA πλασμίδιο που περιέχει μία DNA αλληλουχία η οποία κωδικεύει ένα αντιγόνο υπό τον έλεγχο ρυθμιστικών αλληλουχιών που κατευθύνουν την έκφραση αυτής σε ένα κύτταρο θηλαστικού ή σπονδυλωτού. Η μέθοδος περιλαμβάνει επίσης την χορήγηση στο άτομο μιας δεύτερης σύνθεσης η οποία περιλαμβάνει έναν ανασυνδυασμένο ιό θυλακιώδους στοματίτιδας (VSV) που περιέχει μία αλληλουχία νουκλεϊνικού οξέος η οποία κωδικεύει το αντιγόνο υπό τον έλεγχο ρυθμιστικών αλληλουχιών που κατευθύνουν την έκφραση αυτής σε ένα κύτταρο θηλαστικού ή σπονδυλωτού. Ο rVSV είναι σε μία υλοποίηση ικανός για αναδιπλασιασμό. Τα κιτ για χρήση σε ανοσοποιητικές και θεραπευτικές αγωγές της νόσου περιλαμβάνουν τα συστατικά και τις μεθόδους για την πρακτική εφαρμογή αυτής της μεθόδου.
Patent CY-1111866-T1 (CY)
Inventor: PANNEKOEK ROBERT JOHN
IPC: F21V21/36
Filed: 2010-11-04
Abstract: An elongate member ( 10 ) is provided having a first elongate portion ( 12 ), a second elongate portion ( 14 ) and an interconnecting joint ( 16 ). The interconnecting joint ( 16 ) is disposed at an acute angle to the first elongate portion ( 12 ) and rotation of the second elongate portion ( 14 ) about the interconnecting joint ( 16 ) allows a user access to an article ( 11 ) located at the upper end of the second elongate portion ( 14 ).
Patent CY-1111844-T1 (CY)
Inventor: BELIVEAU RICHARD
IPC: A61P1/16
Filed: 2011-09-15
Abstract: The present invention relates to improvements in the field of drug delivery. More particularly, the invention relates to a non-invasive and flexible method and carrier for transporting a compound or drug across the blood-brain barrier of an individual. In particular the present invention relates to a carrier for transporting an agent attached thereto across a blood-brain barrier, wherein the carrier is able to cross the blood-brain barrier after attachment to the agent and thereby transport the agent across the blood-brain barrier. The present invention relates to improvements in the field of drug delivery. More particularly, the invention relates to a non-invasive and flexible method and carrier for transporting a compound or drug across the blood-brain barrier of an individual. In particular the present invention relates to a carrier for transporting an agent attached thereto across a blood-brain barrier, wherein the carrier is able to cross the blood-brain barrier after attachment to the agent and thereby transport the agent across the blood-brain barrier.
Patent CY-1112232-T1 (CY)
Title: Κινολινικα παραγωγα ως αναστολεις φωσφοδιεστερασης
Inventor: BALDWIN IAN ROBERT
IPC: C07D417/12
Filed: 2012-01-11
Abstract: Παρέχονται σύμφωνα με την εφεύρεση νέες ενώσεις του τύπου (Ι) ή φαρμακευτικώς αποδεκτά άλατά τους, όπου τα R1, R2, R9, R20 και R34 είναι όπως περιγράφονται στην περιγραφή, μέθοδοι παρασκευής τους, σκευάσματα που τις περιέχουν και η χρήση τους στη θεραπευτική για την αντιμετώπιση φλεγμονωδών ασθενειών.
Patent CY-1113600-T1 (CY)
Inventor: GRILLO-LOPEZ ANTONIO
IPC: A61K51/10
Filed: 2012-09-07
Abstract: New combined therapeutic regimens for treatment of B-cell lymphomas are disclosed which comprise in particular administration of anti-CD20 antibodies to patients having low-, intermediate- or high-grade non-Hodgkins lymphomas.
Patent CY-1119286-T1 (CY)
Title: Ανταγωνιστες των wnt και μεθοδοι αγωγης
Inventor: SATYAL SANJEEV H
IPC: C12N15/12
Filed: 2017-09-05
Abstract: Η παρούσα εφεύρεση σχετίζεται με συνθέσεις που περιλαμβάνουν ανταγωνιστές των Wnt και με μεθόδους αγωγής έναντι νόσων και διαταραχών σχετικών με τις Wnt, όπως είναι ένας καρκίνος, καθώς και με μεθόδους επαγωγής διαφοροποίησης, και μείωσης της συχνότητας εμφάνισης καρκινικών βλαστοκυττάρων, αλλά και με καινοφανείς μεθόδους αδρής διαλογής τέτοιων ανταγωνιστών των Wnt. Ιδιαίτερα, η εφεύρεση φέρνει στο προσκήνιο διαλυτούς υποδοχείς FZD, SFRP και Ror καθώς και τη χρήση αυτών.
Patent CY-1119905-T1 (CY)
Title: Ρετροϊικα οχηματα τροποποιημενης ζωνης πολυπουρινης
Inventor: KAFRI TAL
IPC: C12N15/867
Filed: 2018-02-09
Abstract: Παρέχεται μια κασέτα μεταφοράς ρετροϊκού οχήματος με ανεπάρκεια ενσωμάτωσης που στερείται λειτουργικής ζώνης πολυπουρίνης (ΡΡΤ). Επίσης παρέχονται απομονωμένα νουκλεϊνικά οξέα που περιλαμβάνουν μια ετερόλογη νουκλεοτιδική αλληλουχία, μια ή δύο ρετροϊικές τελικές επαναλαμβανόμενες αλληλουχίες (LTRs), ένα σήμα πακεταρίσματος, ένα στοιχείο απόκρισης rev, κι έναν ευκαρυωτικό υποκινητή, όπου το νουκλεϊνικό οξύ στερείται λειτουργικού ΡΡΤ· οχήματα που περιλαμβάνουν τα απομονωμένα νουκλεϊνικά οξέα που αποκαλύπτονται· ανασυνδυασμένα ρετροϊικά σωματίδια και mRNA από αυτά· τυποποιημένες συσκευασίες ρετροϊκού οχήματος· και μεθόδους παραγωγής σωματιδίων οχήματος με ανεπάρκεια ενσωμάτωσης, που επιτυγχάνουν γονιδιακή έκφραση μιας νουκλεοτιδικής αλληλουχίας που παρουσιάζει ενδιαφέρον, και εισαγωγή μιας νουκλεοτιδικής αλληλουχίας που παρουσιάζει ενδιαφέρον στο γονιδίωμα ενός κυττάρου-ξενιστή με σημειακώς εξειδικευμένο ή μη εξειδικευμένο τρόπο.
Patent CY-1120872-T1 (CY)
Title: Μεθοδος για τη ληψη ηπαρινων χαμηλου μοριακου βαρους και πολυ χαμηλου μοριακου βαρους
Inventor: FRANCO RODRÍGUEZ GUILLERMO
IPC: C08B37/10
Filed: 2018-05-21
Abstract: Η παρούσα εφεύρεση σχετίζεται με μια μέθοδο για την παρασκευή ηπαρινών χαμηλού μοριακού βάρους (low molecular weight heparin, LMWH) και ηπαρινών πολύ χαμηλού μοριακού βάρους (very low molecular weight heparin, VLMWH), και περιλαμβάνει τα βήματα της διαλατοποίησης της ηπαρίνης σε ηπαρινικό βενζαλκόνιο, του αποπολυμερισμού σε οργανικό μέσο και της διαλατοποίησης προς σχηματισμό άλατος ενός αλκαλίου ή μετάλλου αλκαλικών γαιών. Η παρούσα εφεύρεση επίσης σχετίζεται με ένα προϊόν που λαμβάνεται μέσω μιας μεθόδου που περιγράφεται στην παρούσα εφεύρεση
Patent CY-1121112-T1 (CY)
Inventor: MENG XIANG-JIN
IPC: C12N15/34
Filed: 2018-11-05
Abstract: The present invention relates to an immunogenic polypeptide product which is obtainable by expressing infectious chimeric DNA clones of porcine circovirus (PCV). The present invention also relates to corresponding vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone is constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position.
Patent HR-P20100512-T1 (HR)
Title: Magnetic rail brake device with asymmetric excitation coils and/or with multi-part coils
Inventor: KASSAN MICHAEL
IPC: B61H7/08
Filed: 2010-09-17
Abstract: The device has a brake magnet (2) e.g. fixed magnet, with a magnetic coil element (8) that supports a magnetic coil (9). A horseshoe-shaped magnetic core (6) has a yoke (28) and bearers (42a, 42b). The coil vertically engages the yoke with an upper cover (30) and a lower cover (32). A cross-section of the coil in the upper cover exhibits a smaller height (h) and a wider breath (b) than a cross-section in the lower cover. The height of the cross-section of the coil is measured parallel and the width of the cross-section is measured transversally to a vertical central axis (38) of the magnet.
Patent SI-1134245-T1 (SI)
Title: Adhesive compositions
Inventor: GANSTER OTTO DR
IPC: C09D175/04
Filed: 2001-03-05
Abstract: An aqueous dispersion of isocyanate reactive polymers containing di- and/or polyisocyanate of melting- and/or softening temperature greater than 30 degrees C as a finely divided powder of mean particle diameter less than 100 micron, preferably less than 50 micron is new.   An Independent claim is included for preparation of an adhesive composition in which the above dispersion is applied to the substrate to be adhesive bonded, the assembly is dried, the dried adhesive coating is decrystallized by heating for a short time at less than 110 degrees C, preferably less than 90 degrees C, and is joined to the substrate in the decrystallized state.
Patent SI-1482529-T1 (SI)
Title: Method of manufacturing of wedges that are positioned between the bimetal and the trigger of a safety switch
Inventor: GANCEL ETIENNE
IPC: H01H69/01
Filed: 2003-05-30
Abstract: The method involves subjecting an electrical apparatus to an overload current to trigger the apparatus. A triggering duration is measured from the application of the current and is compared to a preset triggering duration. The compared duration is converted into a correction distance by a calculator. The distance is utilized by production lines for manufacturing a spacer of length equal to that of standard spacer block. Independent claims are also included for the following: (a) a spacer for connecting a bimetallic strip and a triggering lock of safety apparatus (b) a safety electrical apparatus with a bimetallic strip.
Patent SI-1419837-T1 (SI)
Title: Tool holder with locking system
Inventor: CACHOD YVES MARIE MARCEL
IPC: B23B31/00
Filed: 2003-10-14
Abstract: The chuck comprises a body (2), fixed on the machine motor shaft, in which several jaws (9) are mounted and slide in bores (8), converging to the front, each jaw having an outwards turned threaded part (10). A skirt (25) rotated on the body has an interior wall which engages a nut (12) meshing with the jaws external threaded part. In the body zone covered by the nut are peripheral teeth (30) and the nut carries locking means (35) which engage the teeth in the chuck clamped position.
Patent SI-1517051-T1 (SI)
Title: Hinge for wall fastening by chemical resin
Inventor: ARDESI PAOLO
IPC: E05D5/12
Filed: 2004-09-14
Abstract: The invention relates to a hinge (1), in particular for shutters, suitable for being fastened in a hole (3) in a wall (4) by means of a chemical fastening substance, such as a resin, comprising a stem or shank (2) designed to be inserted into said hole (3) in the wall (4), and a pin (7), which extends from the proximal end of said stem or shank (2) protruding from the wall (4). A cavity (12) extends longitudinally in said stem or shank (2), which opens from the side of the pin (7) to allow the chemical fastening substance to be injected inside, when the stem or shank (2) is inserted into the hole (3) in the wall (4) and connected externally by at least one further opening (13) in the stem or shank (2) to allow the fastening substance to come out of the cavity (12) in the hole (3). <IMAGE>
Patent SI-1678099-T1 (SI)
Title: Dense mortar based on binary ettringite binder, comprising at least one poly(alkylene oxide) comb polymer and at least one structuring organic resin
Inventor: AMATHIEU LORIS
IPC: C04B28/06
Filed: 2004-10-22
Abstract: Dense mortar based on an ettringite binder (calcium sulfate/calcium aluminate) and an organic structuring resin also contains a polyalkylene oxide with a comb-like structure. Dense mortar containing (i) an ettringite binder comprising calcium sulfate and a mineral compound of calcium aluminates consisting of oxides of calcium (C) and aluminum (A), soluble and combined in one or more crystallised and/or amorphous mineralogical phases in which the effective mol ratio of C/A = 1.2-2.7 and the total weight of the phases (C + A) is at least 30 wt% of that of the mineral compound, (ii) polyalkylene oxide(s) with a comb-shaped polymer structure (PCP) and (iii) less than 2 wt% organic structuring resin(s).
Patent SI-1596020-T1 (SI)
Title: Partition
Inventor: SCHMID CLAUS
IPC: E04B2/00
Filed: 2005-05-11
Abstract: The sliding partition consists of several rectangular panels (E) with peripheral frames filled in by wood, metal or glass panels. The upper support rail (T) engages a sliding bolt (A) on the upper door frame member (1). A lower guide rail (F) in the floor engages a pin on the lower door frame member (2). There are seals (6) at the top and at the bottom (7) the doors may be moved by hand or by an electric motor.
Patent SI-1851239-T1 (SI)
Title: Replication-deficient rna viruses as vaccines
Inventor: NEUBERT WOLFGANG J
IPC: C12N15/00
Filed: 2006-02-10
Abstract: Recombinant negative-strand RNA virus (I) comprises a viral genome with a mutation in the N, L or P gene that results in loss of replication capability without loss of transcription capability. Independent claims are also included for: (1) nucleocapsid (II) of (I); (2) genome (III) of (I); (3) DNA molecule (IV) coding for the genome or antigenome of (I); (4) cell (V) containing (I), (III) or (IV); (5) producing (I) by providing a cell transfected with a DNA molecule coding for (I) and optionally a heterologous gene product, and culturing the cell under conditions suitable for transcription of the DNA molecule; (6) multiplying (I) by providing a cell infected with (I) and culturing the cell under conditions suitable for multiplication of (I); (7) pharmacuetical composition comprising (I), (II) or (III); (8) use of a cell (VI) that stably expresses the N, L or P protein of a negative-strand RNA virus in a constitutive or inducible manner for producing or multiplying (I) (II) or (III). ACTIVITY : Virucide. MECHANISM OF ACTION : Vaccine; Ribozyme; Antisense oligonucleotide inhibitor; RNAi; RNA interference.
Patent SI-2155464-T1 (SI)
Title: Demolding device for demolding a tool from a mold
Inventor: JUNG HORST
IPC: B29C45/40
Filed: 2007-10-23
Abstract: A demolding device (10) for demolding a work piece from a mold comprises a hold-down element (18) that is disposed between the mold pieces in the closed state of the mold and extends up to or into a cavity provided for producing the work piece. A control sleeve (11) is connected to the hold-down element (18) and is coupled with one of the mold parts in a form-fitting manner via a guide device. The piston (11) is displaceable along a first path (w1) along the stroke direction limited by the guide device and is mounted in the guide device in a pivotable fashion. Upon a pivot motion, the end of the piston (11) facing the cavity moves away from the cavity. A first control piece (16) is connected to the other mold piece, the control piece blocking a pivoting of the piston (11) and/or the hold-down element (18) during the first path (w1).
Patent SI-2500730-T1 (SI)
Title: Soluble urokinase plasminogen activator receptor (suPAR) as diagnostic marker for low-grade inflammation
Inventor: EUGEN-OLSEN JESPER
IPC: G01N33/00
Filed: 2007-12-21
Abstract: The invention concerns a marker for low-grade inflammation and metabolic syndrome (MS) and MS-related diseases and/or low-grade inflammation-related diseases such as cardiovasculardisease, ischemic heart disease and type 2 diabetes. More particularly it concerns the measurement of the concentration of soluble urokinase plasminogen activator receptor (suPAR) in human biological fluids (sputum, cystic fluid, ascites, serum, plasma, urine) as a tool of diagnosing and/or prognosticating low-grade inflammation and metabolic syndrome and the risk of development of the related diseases such as cancer, cardiovascular disease, ischemic heart disease and type 2 diabetes.
Patent DE-3782245-T2 (DE)
Inventor: WALKER KENT
IPC: H04H20/88
Filed: 1987-09-16
Granted: 1993-04-15
Abstract: A system for companding digital audio signal samples processes the digital audio signal samples to correct errors induced by the compression and expansion processes. These errors are calculated prior to compressing the samples. Such errors are calculated in accordance with a predetermined compression process and a predetermined expansion process; and the digital audio signal samples are corrected in accordance with such calculations prior to compression. The compression process includes providing a 3-bit gain word for a block of 70 samples. The gain word is computed in accordance with the position of the most significant "1" bit in the sample(s) having the peak magnitude. Each individual sample is processed in accordance with the block gain word to compress the sample by reducing the number of magnitude bits. The error calculation process includes calculating an error signal by subtracting a calculated reproduced digital audio signal sample from the digital audio signal sample to be compressed, filtering the error signal by noise-spectral filtering and adding the filtered error signal to the next-providing digital audio signal sample to provide a corrected digital audio signal sample for compression. The error calculation process also includes calculating an error value based upon the effect of using a single gain word for compressing a block of samples. The error value is subtracted from the corrected digital audio signal sample prior to compression. The gain word is forward error corrected by (5,1) encoding to enable detection and correction of both single-bit and double-bit errors in transfer by majority voting. The sign bit and the most significant magnitude bits of the compressed samples are forward error corrected to enable detection and correction of single-bit errors in transfer and to enable detection and concealment of double-bit errors in transfer.
Patent DE-3784256-T2 (DE)
Inventor: GERULIS BENEDICT R
IPC: B01D27/10
Filed: 1987-03-02
Granted: 1993-08-12
Abstract: A self-cleaning canister type filter (1) comprises a cylindrical canister enclosure (3) which has, at one end, end plate (2) with fluid inlets (4) and outlet (6) therein. A spring-loaded hollow annular piston (30) is slideably mounted on the exterior of a central tubular cylinder (10) and within an upper cylinder (28) for a downward movement against a compression spring (32) to initially force a back-flow of filtered fluid through a filter element (14), lifting contaminant particulate solids from its filtering surface (15). An inlet valve opening (64) is opened to fluid flow when piston (30) attains a compressed position. Filter element (14) is closely spaced to the canister enclosure inner wall surface (9) for rapid flow of fluid over the inlet surface (15) of the filter element (14) to scour solids to a sump (5) in the lower portion of the canister enclosure (3). A lower spring-loaded piston (18) communicates with sump (5) and is forced upward by entering contaminated fluid until an attached sleeve valve piston (23) slideably mounted in tubular cylinder (10) opens to permit filtered fluid to exit the filter (1), resulting in normal filtration flow of fluid through filter element (14).
Patent DE-3786163-T2 (DE)
Inventor: DEMIT JOEEL
IPC: C22C29/00
Filed: 1987-12-29
Granted: 1994-01-27
Abstract: It is known to produce ceramic-metal composites developed by powder metallurgy (or ceramic) technology from a ceramic powder and a metal powder. To improve the bonding between the ceramic phase and the metal phase, a surface-active additive of metal type, chosen from the group of the elements Ti, V, Sc, Zr, Y, Nb, Hf, La and rare earths, and Ta, is added to the mixture of the metal and ceramic powders, preferably in the form of a pulverulent compound capable of decomposing under the action of heat, the combination of the powders, after the usual treatment, being formed and sintered to obtain a coherent monolith, where the ceramic phase is predominant in volume, namely 50% to 95%, the metal phase is minor in volume, namely 50% to 5%, and where the surface-active metal provides the bonding at the interfaces of the phases with or without formation of a compound or alloy.
Patent DE-3852409-T2 (DE)
Inventor: FORSSEN ERIC ANTON
IPC: A61K9/133
Filed: 1988-01-22
Granted: 1995-04-20
Abstract: Compositions comprising phospholipid-encapsulated vesicles of active ingredient and triglyceride are described. In a preferred embodiment the vesicles are composed of a hexamethylmelamine active ingredient, with trilaurin or trimyristin as the triglyceride and a mixture of distearoylphosphatidylcholine, distearoylphosphatidylglycerol and cholesterol in the phospholipid outer layer. Preferably the molar ratios of active ingredient: triglyceride : DSPC : CHOL : DSPG will be from about 1:4:2:1:0 to about 1:4:1:1:1. Glycerol may be added to the carrier phase to reduce agglomeration. The composition may be used to deliver otherwise aqueous-insoluble agents to humans or animals to treat, for example, tumors.