Patent SG-11201901611Y-A (SG)
Title: Methods for the identification, targeting and isolation of human dendritic cell (dc) precursors "pre-dc" and their uses thereof
Inventor: GINHOUX FLORENT
IPC: G01N33/68
Filed: 2017-08-31
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 March 2018 (08.03.2018) WIPO I PCT mu °million °nolo olomomiollionoiflo ois (10) International Publication Number WO 2018/044238 Al (51) International Patent Classification: G01N 33/50 (2006.01) A61P 31/12 (2006.01) G01N 33/68 (2006.01) A61P 3/04 (2006.01) G01N 33/564 (2006.01) A61P 29/00 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61K 35/15 (2015.01) A61P 37/00 (2006.01) (21) International Application Number: PCT/SG2017/050435 (22) International Filing Date: Immunology Network, 8A Biomedical Grove, #04-06 Im- munos, Singapore 138648 (SG). (74) Agent: SPRUSON & FERGUSON (ASIA) PTE LTD; P.O. Box 1531, Robinson Road Post Office, Singapore 903031 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 31 August 2017 (31.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201607246S 31 August 2016 (31.08.2016) SG 10201703621Q 03 May 2017 (03.05.2017) SG (71) Applicant: AGENCY FOR SCIENCE, TECHNOLO- GY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, #20-10 Connexis North Tower, Singapore 138632 (SG). = (72) Inventors: GINHOUX, Florent; c/o Singapore Immunol- ogy Network, 8A Biomedical Grove, #04-06 Immunos, Sin- gapore 138648 (SG). SEE, Chi Ee Peter; c/o Singapore (54) Title: METHODS FOR THE IDENTIFICATION, TARGETING AND ISOLATION OF HUMAN DENDRITIC CELL (DC) PRECURSORS \"PRE-DC\" AND THEIR USES THEREOF FIG. 31 (57) : Biomarkers for the detection and identification of a pre- cursor of conventional dendritic cell (cDC) (pre-DC) and its cell sub- sets (pre-cDC1 or pre-cDC2), are defined, which include CD169, CD327, AXL, CD271, CD324 and combinations thereof for detecting pre-DCs. Methods for detecting a disease or condition, prognosis of an existing disease or condition comprising determining the number of pre-DC cells in sample from a subject as compared to control, as well as methods of treating a patient comprising administration of antibodies against CD169, CD327, AXL, CD271, CD324 and combinations thereof are also dis- closed. In addition, an immunogenic composition comprising one or more binding molecules specific for one or more biomarkers or antigen of a target disease and/or one or more cells selected from the group consisting of early pre-DC, pre-cDC1 and pre-cDC2 are also disclosed for eliciting an immune response against an infectious disease or cancer. W O 20 18/0 44238 Al [Continued on next page] WO 2018/044238 Al MIDEDIMOMMIDIRMOINNHOEHOMMOMEEM TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3))