Patent SG-11201909927R-A (SG)
Title: Dosing regimen for treatment of cognitive and motor impairments with blood plasma and blood plasma products
Inventor: BRAITHWAITE STEVEN P
IPC: A61K35/14
Filed: 2018-04-24
Abstract: SalinePPF 3xwk PPF1 Pulse E —30000- E § 20000 3 b l0000 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 November 2018 (01.11.2018) WIPO I PCT Hu omit VIII °nolo VIII 100110111110 oimIE (10) International Publication Number WO 2018/200560 Al (51) International Patent Classification: A61K 38/38 (2006.01) A61P 25/00 (2006.01) A61K 35/14 (2006.01) A61P 25/28 (2006.01) (21) International Application Number: PCT/US2018/029189 (22) International Filing Date: 24 April 2018 (24.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/490,519 26 April 2017 (26.04.2017) US 62/584,571 10 November 2017 (10.11.2017) US 62/623,468 29 January 2018 (29.01.2018) US 62/641,194 09 March 2018 (09.03.2018) US (71) Applicant: ALKAHEST, INC. [US/US]; 75 Shoreway Road, Suite D, San Carlos, California 94070 (US). (72) Inventors; and (71) Applicants: BRAITHWAITE, Steven P. [GB/US]; 75 Shoreway Road, Suite D, San Carlos, California 94070 (US). CZIRR, Eva [DE/US]; 75 Shoreway Road, Suite D, San Carlos, California 94070 (US). GALLAGER, Ian [US/US]; 75 Shoreway Road, Suite D, San Carlos, Cal- ifornia 94070 (US). HUBER, Nina [CH/US]; 75 Shore- way Road, Suite D, San Carlos, California 94070 (US). MI- NAMI, S. Sakura [US/US]; 75 Shoreway Road, Suite D, San Carlos, California 94070 (US). (74) Agent: FIELD, Bret E.; 201 Redwood Shores Parkway, Suite 200, Redwood City, California 94065 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 2 I (3)) (54) Title: DOSING REGIMEN FOR TREATMENT OF COGNITIVE AND MOTOR IMPAIRMENTS WITH BLOOD PLASMA — AND BLOOD PLASMA PRODUCTS Figure 1 A B 40000 W O 20 18/ 2005 60 Al Saline F PF1 3x/wk PPF1 Pulse (57) : Methods and compositions for treating and/or preventing aging-related conditions are described. The compositions used in the methods include blood plasma and blood plasma fractions derived from blood plasma with efficacy in treating and/or preventing aging-related conditions such as cognitive disorders. The methods relate to a regimen of pulsed dosing of blood plasma or blood plasma fractions.