baber/WOPTO huggingface dataset:
Patent CA-2593713-A1 (CA)
Title: X-ray structure of human fpps and use for selecting fpps binding compounds
Inventor: STRAUSS ANDRE
IPC: C12N9/10
Filed: 2006-01-02
Abstract: The present invention relates to crystalline human farnesyl diphosphate synthase (FPPS), to the three-dimensional structure of free FPPS, as well as the three-dimensional structures of FPPS in complex with substrates such as IPP (isopentenyl diphosphate) and/or with inhibitors, such as Zometa~ or Aredia~. Further, methods for preparing crystals of human FPPS are described.  According to the invention the crystals can be used to determine the structures of FPPS homologs, mutants, complexes with ligands, FPPS crystal forms and similar molecules of unknown structure. The invention further relates to the use of FPPS crystals to select new FPPS ligands, e.g., by X-ray screening and to design and/or identify inhibitors against FPPS. Furthermore, the invention relates to NMR methods for selecting and/or identifying new low molecular weight binders to FPPS, which represent new therapeutic agents.
Patent CA-2594939-A1 (CA)
Title: Solid peroral contraceptive drug
Inventor: FRICKE SABINE
IPC: A61K31/567
Filed: 2006-02-15
Abstract: Disclosed is a solid peroral contraceptive drug containing 17a-cyanomethyI-17-ß-hydroxyestra-4,9-dien-3on (dienogest) at a daily dose that is equal to or smaller than 2.0 mg as one active component and 17a-ethinyl estradiol (ethinyl estradiol) at a daily dose of less than 0.03 mg as another active component along with one or several pharmaceutically acceptable carriers. The dienogest is proportionately released in at least two phases while the ethinyl estradiol is released at the same time as the first phase of the dienogest.
Patent CA-2601900-A1 (CA)
Title: Low density cements for use in cementing operations
Inventor: FRASER MICHAEL R
IPC: C04B28/10
Filed: 2007-09-14
Abstract: A cement mix which is suitable for cementing in subterranean formations to provide zonal isolation or for blocking or plugging an abandoned pipeline or back filling a mine shaft, tunnel or excavation contains Portland cement or a mixture of two components selected from Portland cement, fly ash, slag, silica fume, gypsum, limestone and bentonite; and diatomaceous earth, preferably having a BET nitrogen adsorption specific surface area between from about 30 to about 100 m2/g. The cement mix may further contain an alkali metasilicate and/or alkali silicate, zeolite and/or aluminum silicate, an accelerator, such as an inorganic salt, and/or an alkaline metal oxide, as well as a lightweight density modifying agent, including glass, ceramic or plastic spheres. A cementitious slurry, formulated from the cement mix, has a density less than or equal to 1500 kg/m3 and exhibits good compressive strength.
Patent CA-2602116-A1 (CA)
Inventor: BJOERKHOLM LARS
IPC: A24F23/02
Filed: 2006-03-07
Abstract: A box comprising an open container (2) and a Hd (3) for closing the open container (2), the box (1) in a closed state comprising two base surfaces (4, 5), one of which consists of the bottom wall (4) of the open container and the other of the top wall (5) of the lid (3), together with at least one lateral surface, which is formed by a container side (6) and a lid side (7). When the box (1) is in the closed state the container side (6) and the lid side (7) at least partial overlap one another. An inward facing, inclined slide surface (19) is furthermore arranged on the inside of the top wall (5) of the lid (3) in order, when closing the open container (2), to allow displacement of the lid (3) into the correct closing position relative to the container (2). The slide surface (19) runs along and adjacent to the lid side (7) at an angle relative to the top wall (5) and the lid side (7) and is remote from the lid side (7).
Patent CA-2602222-A1 (CA)
Title: Fermeture de contenant au moyen d'une portion sus-jacente pouvant etre percee par une aiguille et scellee, et portion sus-jacente compatible avec un produit liquide renfermant du gras, et appareil et methode associes
Inventor: SAHOO DEBASHIS
IPC: B65D41/20
Filed: 2006-01-25
Abstract: La présente invention concerne un récipient et un procédé destinés au stockage de produits liquides gras, tels qu'une préparation lactée pour nourrisson ou bébé ou d'autres produits à base de lait. Le récipient comprend un corps définissant une chambre de stockage destinée à recevoir un produit liquide gras aseptique, et une première ouverture communiquant en termes de fluide avec la chambre de stockage. Le corps ne lixivie pas plus qu'une quantité prédéterminée de produits lixiviables dans le produit liquide gras et n'altère pas de manière non souhaitable un profil de goût du produit liquide gras. Un assemblage de fermeture de récipient comprend un bouchon pouvant être adapté à la première ouverture pour sceller hermétiquement la chambre de stockage. Le bouchon comprend une première partie de matériau définissant une surface interne communiquant en termes de fluide avec la chambre de stockage formant au moins la majeure partie de la superficie de la fermeture de récipient qui peut entrer en contact avec n'importe quel produit liquide gras à l'intérieur de la chambre de stockage et qui ne lixivie pas plus qu'une quantité prédéterminée de produits lixiviables dans le produit liquide gras ou n'altère pas de manière non souhaitable un profil de goût du produit liquide gras. Une seconde partie de matériau du bouchon (i) recouvre la première partie de matériau et ne peut entrer en contact avec aucun produit dans la chambre de stockage, ou (ii) forme une superficie sensiblement plus petite de la fermeture de récipient qui peut entrer en contact avec n'importe quel produit dans la chambre de stockage par comparaison avec la première partie de matériau. La seconde partie de matériau peut être pénétrée par une aiguille de façon à remplir avec un produit la chambre de stockage, et une ouverture d'aiguille résultante formée dans la seconde partie de matériau est thermiquement rescellable telle que par l'application d'une énergie de laser pour sceller le produit à l'intérieur de la chambre de stockage. Une partie de scellage de la fermeture de récipient peut s'engager avec le corps avant que l'aiguille remplisse la chambre de stockage pour former de ce fait un joint hermétique sensiblement sec entre la fermeture de récipient et le corps.
Patent CA-2602268-A1 (CA)
Inventor: JENKINS SCOTT
IPC: A61K9/26
Filed: 2006-04-12
Abstract: The invention relates to a controlled release composition comprising a cephalosporin that in operation delivers the drug in a pulsed or bimodal manner for the treatment of bacterial infection. The controlled release composition comprises an immediate release component and a modified release component; the immediate release component comprising a first population of cephalosporin-containing particles and the modified release component comprising a second population of cephalosporin-containing particles coated with a controlled release coating; wherein the combination of the immediate release and modified release components in operation deliver the active ingredient in a pulsed or bi-modal manner. Preferably, the cephalosporin is cefcapene pivoxil or a salt thereof which can be released from the dosage form in an erodable, diffusion and/or osmotic-controlled release profile.
Patent CA-2603837-A1 (CA)
Inventor: CEDOZ ROGER T
IPC: B05B12/14
Filed: 2006-04-10
Abstract: A spray applicator system (10) is provided with a reservoir manifold assembly (16) having a separate reservoir for each different coating to be applied.  Reservoirs are filled from a coating supply system and isolated electrically from the supply system when coating is dispensed from a reservoir to the applicator (12). Multiple sets of reservoirs can be used, so that an empty reservoir in one set can be filled while coating is dispensed from a reservoir in the other set. The set of reservoirs in which a reservoir is being filled is isolated electrically from the applicator, and of the set of reservoirs in which a reservoir is dispensing coating to the applicator (12) is isolated electrically from the supply system.
Patent CA-2604648-A1 (CA)
Inventor: JORDAN REINHARD
IPC: A01D45/00
Filed: 2007-09-28
Abstract: A mower sickle bar has an elongated metal bar having a longitudinally extending edge region that is tempered and thereadjacent a longitudinally extending middle region that is not tempered. The untempered middle region is formed with a row of throughgoing holes. A longitudinally extending row of blades lying on the metal bar at least partially over the untempered middle region thereof is secured thereto by fasteners projecting through the holes and through the blades.
Patent CA-2604969-A1 (CA)
Inventor: OSTERTAG KATHRYN LYNN
IPC: A61B5/00
Filed: 2006-04-19
Abstract: This invention provides monitoring garments for non-invasively monitoring physiological parameters in un-restrained and/or restrained animals, such as monkeys, rabbits, dogs, horses, and the like. The invention also includes methods and systems for collecting and processing monitoring data.
Patent CA-2605455-A1 (CA)
Title: Display-equipped key, key assembly
Inventor: BROWN RONALD
IPC: G06F3/023
Filed: 2006-04-18
Abstract: A display key, data input device and related methods with the display key formed of a plurality of snap-together components housing a display therein which is dynamically configurable. At least one of the components includes an integral seat that orients and can also locate the display relative to a key top ensuring it can be viewed. A preferred display key assembly includes onboard display driver circuitry that seats in an integral seat of a key base having a conventional plunger and which is of snap fit construction of a keycap having at least a portion of which being translucent or transparent to permit an image generated by the display to be viewed by a user of a processing unit controlled by the display key equipped data in ut device.
Patent CA-2606365-A1 (CA)
Inventor: GUPTA VINITA
IPC: H04B10/12
Filed: 2007-10-09
Abstract: An apparatus and a method for verifying optical system performance using a signaling value test are disclosed. After instructing the first optical interface device and the second optical interface device to enter a verification mode, the first optical interface device sends first verification data to the second optical interface device via an optical communications network.  In one embodiment, the first optical interface device is an optical line termination ("OLT") and the second optical interface device is an optical network terminal ("ONT").  Upon composing the first reply message in response to content received by the second optical interface in accordance with the first verification data, the second optical interface device forwards the first reply message to the first optical interface device.
Patent CA-2607536-A1 (CA)
Inventor: DURIE ANTHONY ROBERT
IPC: H04L9/00
Filed: 2007-10-24
Abstract: Methods and apparatus for optimizing security configurations of a set of computers are disclosed. A set of local servers, each functioning as a deep-security manager supporting a respective subset of the computers, maintains protection software containing filters and rules for deploying each filter. A local server receives updated protection software from a central server. Each local server interrogates each computer of its subset of computers to acquire computer-characterizing data and applies relevant rules to determine an optimal set of filters for each computer. Each rule adaptively determines required characterizing data elements from each computer for determining an optimal security configuration. A local server updates the security configuration of a computer to suit changes in the operational environment of the computer.
Patent CA-2610565-A1 (CA)
Title: Tarping system transport method
Inventor: HUNT MARVIN
IPC: B60P7/02
Filed: 2006-06-06
Abstract: A method for shipping a retractable cover system include pre- assembling the cover system to include the flexible cover and enough components to support the cover on guide rails mounted to a trailer or other transport vehicle. At least two pre-assembled cover systems are compressed along their length and then loaded sequentially onto the guide rails of the same trailer. In certain embodiments, four compressed partially pre- assembled cover systems are loaded onto a single trailer. The trailer is then transported to one or more customer sites where one or more of the compressed cover systems are unloaded. The cover systems may be only partially pre-assembled, with the remaining components placed on the trailer within the compressed cover system when it is loaded on the trailer. The cover systems may be maintained in their compressed state by a tension element or tensioned apron wrapped around the compressed cover system.
Patent CA-2611689-A1 (CA)
Inventor: BRADFORD DAVID C
IPC: B01D21/26
Filed: 2006-06-09
Abstract: The present invention relates to an improved method fro reclaiming and recycling developing solvents used in the production of flexographic printing plates. More specifically, the invention relates to reclaiming and recycling developing solvent through centrifugation and/or filtration. According to the invention, the solvent used to develop the printing plates can be reclaimed and/or recycled by simply centrifuging the polymer-contaminated solvent. In certain embodiment, the centrifuged solvent is further filtered. The process involves transferring the contaminated solvent, from a plate processor (22) or dirty holding tank (30), to a centrifuge (20) and/or filter (50), and centrifuging and/or filtering the contaminated solvent to remove the polymer.  The reclaimed solvent can be transferred directly back to the plate processor (22) or to a clean holding tank (28).
Patent CA-2611777-A1 (CA)
Title: Modifying agent composition for polyolefins
Inventor: AMOS STEPHEN E
IPC: C08L23/02
Filed: 2006-06-16
Abstract: A polymer modifying agent composition, a polymer composition that uses the modifying agent composition and a method of improving the processing, physical and optical properties of a thermoplastic polymer are provided. The polymer modifying agent composition comprises a nucleating and/or clarifying agent and a dispersing agent.
Patent CA-2615415-A1 (CA)
Title: Method for producing virus-type particles containing an active substance
Inventor: RUEHLAND CLAUS
IPC: C07K14/005
Filed: 2006-03-28
Abstract: The invention relates to a method for producing virus-type particles containing an active substance. Proteins, which comprise a first amino acid sequence which is derived from a first virus protein, and fusion proteins are assembled in order to form the virus-type particles. The proteins and the fusion proteins are coexpressed in yeast cells.
Patent CA-2617582-A1 (CA)
Title: Biopsy device with fluid delivery to tissue specimens
Inventor: SHABAZ MARTIN V
IPC: A61B17/00
Filed: 2006-08-04
Abstract: The invention is directed to a system and method for separating and collecting one or more tissue specimens from a target site within a patient and flushing the specimen to remove blood, debris and the like before the specimen is removed from the biopsy device. The flow of flushing fluid to the tissue collector is preferably controlled to coincide with delivery of one or more specimens to the collecting tray or basket of the device or after the receipt of the specimen within the tissue collector to ensure that the fluid (16) is applied to a fresh specimen. The tissue tray or basket within the tissue collector (14) has an open or foraminous portion to facilitate removal of fluid, such as the applied fluid and blood, and other debris from the tissue specimens on the tray. Vacuum (22) is provided within the tissue collector, preferably under the tray to remove fluid and debris from the collector interior.
Patent CA-2619469-A1 (CA)
Title: Composite bone graft cement comprising calcium sulfate dihydrate and brushite
Inventor: MCCANLESS JONATHAN D
IPC: A61L27/42
Filed: 2006-09-08
Abstract: The invention provides a particulate composition adapted for forming a bone graft substitute cement upon mixing with an aqueous solution, including i) a calcium sulfate hemihydrate powder having a bimodal particle distribution and a median particle size of about 5 to about 20 microns, wherein the calcium sulfate hemihydrate is present at a concentration of at least about 70 weight percent based on the total weight of the particulate composition; ii) a monocalcium phosphate monohydrate powder; and iii) a .beta.-tricalcium phosphate powder having a median particle size of less than about 20 microns.  Bone graft substitute cements made therefrom, a bone graft substitute kit comprising the particulate composition, methods of making and using the particulate composition, and articles made from the bone graft substitute cement are also provided.
Patent CA-2620381-A1 (CA)
Inventor: RYLE MATTHEW
IPC: B01L99/00
Filed: 2006-09-27
Abstract: The invention provides sample tracking systems and methods. A sample tracking system can comprise a plate having a plurality of sample wells and an apparatus for illuminating each individual sample well, wherein the manner with which the sample well is illuminated can track the loading of the sample components to the sample wells.
Patent CA-2622210-A1 (CA)
Inventor: YESLAND KYLE D
IPC: A61K38/17
Filed: 2006-10-23
Abstract: Compositions containing a glycosylated therapeutic amino acid sequence obtained from a transgenic avian wherein the therapeutic amino acid sequence is a glycoprotein and includes a covalently bonded glycol polymer.
Patent CA-2622741-A1 (CA)
Title: 2-heteroaryl-pyrazolo-[4, 3-e]-1, 2, 4-triazolo-[1,5-c]-pyrimidine as adenosine a2a receptor antagonists
Inventor: NEUSTADT BERNARD R
IPC: A61P25/00
Filed: 2006-09-15
Abstract: Compounds having the structural formula (I) or a pharmaceutically acceptable salt thereof, wherein R is R1-isoxazolyl, R1-oxadiazolyl, R1-dihydrofuranyl, R1-pyrazolyl, R1-imidazolyl, R1-pyrazinyl or R1-pyrimidinyl; R1 is 1 , 2 or 3 substituents selected from H, alkyl, alkoxy and halo; Z is optionally substituted-aryl, or optionally substituted-heteroaryl; are disclosed, as well as their use in the treatment of central nervous system diseases, in particular Parkinson's disease and Extra Pyramidal Syndrome, pharmaceutical compositions comprising them, and combinations with other agents.
Patent CA-2623559-A1 (CA)
Inventor: KUTSUKAKE YUSUKE
IPC: G02B1/14
Filed: 2006-09-15
Abstract: A plastic lens includes: a plastic lens base material; a hard coat layer formed on the plastic lens base material; an organic antireflection film formed on the hard coat layer; and a primer layer between the plastic lens base material and the hard coat layer. The plastic lens base material contains at least a sulfur atom. The hard coat layer contains at least: fine metal oxide particles containing a titanium oxide having a rutile-type crystalline structure; and an organosilicon compound represented by a general formula of R1SiX1 3. The antireflection film contains a coating composition containing at least: an organosilicon compound represented by a general formula of XmR2 3-mSi-Y-SiR2 3-mXm; an epoxy group-containing organic compound containing one or more epoxy group in a molecule; and fine silica particles with average particle size of 1 to 150 nm, the antireflection film having a refractive index lower than that of the hard coat layer by 0.10 or more.
Patent CA-2624926-A1 (CA)
Inventor: VERENTCHIKOV ANATOLI N
IPC: B01D59/44
Filed: 2006-10-11
Abstract: The disclosed apparatus includes a multi-reflecting time-of-flight mass spectrometer (MR-TOF MS) (11) comprising a pair of grid- free ion mirrors (12), a drift space (13), an orthogonal ion accelerator (14), an optional deflector (15), an ion detector (16), a set of periodic lenses (17), and an edge deflector (18). To improve the duty cycle of the ion injection at a low repetition rate dictated by a long flight in the MR-TOF MS, multiple measures may be taken. The incoming ion beam and the accelerator may be oriented substantially transverse to the ion path in the MR-TOF, while the initial velocity of the ion beam is compensated by tilting the accelerator and steering the beam for the same angle. To further improve the duty cycle of any multi-reflecting or multi-turn mass spectrometer, the beam may be time-compressed by modulating the axial ion velocity with an ion guide. The residence time of the ions in the accelerator may be improved by trapping the beam within an electrostatic trap. Apparatuses with a prolonged residence time in the accelerator provide improvements in both sensitivity and resolution.
Patent CA-2626776-A1 (CA)
Inventor: LARSON DONALD K
IPC: G02B6/38
Filed: 2006-10-20
Abstract: An optical connector for terminating an optical fiber comprises a housing configured to mate with a receptacle and a collar body disposed in the housing. The collar body also includes a mechanical splice disposed in a second portion of the collar body, the mechanical splice configured to splice the second end of the fiber stub to a second optical fiber. The collar body also includes a buffer clamp configured within a third portion of the collar body, the buffer clamp configured to clamp at least a portion of a buffer cladding of the second fiber upon actuation. A field termination platform and method for field termination of an optical fiber in the optical fiber connector are also provided. The field termination platform includes a base configured to hold the optical fiber connector. An actuation mechanism is disposed on the base to actuate the splice element of the optical connector and to actuate the buffer clamping portion of the optical connector. A fiber holder is provided to hold the optical fiber in the termination platform during termination.
Patent CA-2627374-A1 (CA)
Inventor: BEJAR ISAAC I
IPC: G09B7/02
Filed: 1997-03-21
Abstract: The present invention provides systems and methods for controlled presentation of constructed responses through a variety of computer applications to human evaluators for assessment.  The systems and methods further provide for controlled presentation of the constructed responses to minimize the influences of psychometric factors on the accuracy of the human evaluators' assessments and to maximize the ability to efficiently generate data for use in analyzing the accuracy of the human evaluators' assessments and the difficulty of the constructed response categories or questions. The systems and methods of the present invention utilize a memory which relationally stores data regarding the human evaluators, the constructed responses, the scores awarded, and the computer applications to utilize. The systems (10) also comprise assessment stations (40a, 40b, 40n) and a processor (14) for selectively transmitting constructed responses to the assessment stations (40a, 40b, 40n), and receiving scores awarded by the human evaluators assigned to the assessment stations (40a, 40b, 40n).
Patent CA-2629153-A1 (CA)
Inventor: PIERCE JERRY APFFEL
IPC: G11B20/00
Filed: 2006-11-17
Abstract: An optical article that can transform from a pre-activated state of functionality to an activated state of functionality is provided. The optical article includes a radio frequency circuitry coupled to the optical article for interacting with a signal, wherein said signal comprises a thermal signal, an electrical signal, or both, and a convertible material in operative association with the radio frequency circuitry for altering the functionality of the optical article from the pre-activated state to the activated state upon interaction with the thermal energy.