Patent SG-11201807539U-A (SG)
Title: Heterocyclic compound
Inventor: IKEDA SHUHEI
IPC: C07D413/14
Filed: 2017-03-30
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization MD 1111101110101011111 0101111101110101101 0101101101111101111011# International Bureau ... ..... ..Yi j (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/171100 Al 5 October 2017 (05.10.2017) IN I PO I P CT (51) International Patent Classification: 2510012 (JP). OGURO, Yuya; c/o TAKEDA PHARMA- CO7D 401/06 (2006.01) A61K 31/454 (2006.01) CEUTICAL COMPANY LIMITED, 26-1, Muraoka-Hi- CO7D 405/14 (2006.01) A61K 31/41 (2006.01) gashi 2-chome, Fuj isawa-shi, Kanagawa, 2510012 (JP). C07D 413/06 (2006.01) A61P 25/00 (2006.01) NAKAMURA, Minoru; c/o TAKEDA PHARMACEUT- C07D 413/14 (2006.01) A61P 37/00 (2006.01) ICAL COMPANY LIMITED, 26-1, Muraoka-Higashi 2- chome, Fuj isawa-shi, Kanagawa, 2510012 (JP). (21) International Application Number: MURAKAMI, Masataka; c/o TAKEDA PHARMA- PCT/JP2017/014597 CEUTICAL COMPANY LIMITED, 26-1, Muraoka-Hi- (22) International Filing Date: gashi 2-chome, Fujisawa-shi, Kanagawa, 2510012 (JP). 30 March 2017 (30.03.2017) (74) Agent: TAKASHIMA, Hajime; Meiji Yasuda Seimei (25) Filing Language: English Osaka Midosuji Bldg., 1-1, Fushimimachi 4-chome, Chuo- ku, Osaka-shi, Osaka, 5410044 (JP). (26) Publication Language: English (81) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of national protection available): AE, AG, AL, AM, 2016-071181 31 March 2016 (31.03.2016) JP AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (71) Applicant: TAKEDA PHARMACEUTICAL COM- BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, PANY LIMITED [JP/JP]; 1-1, Doshomachi 4-chome, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, Chuo-ku, Osaka-shi, Osaka, 5410045 (JP). HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (72) Inventors: IKEDA, Shuhei; c/o TAKEDA PHARMA- MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, CEUTICAL COMPANY LIMITED, 26-1, Muraoka-Hi- NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, gashi 2-chome, Fujisawa-shi, Kanagawa, 2510012 (JP). RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, SUGIYAMA, Hideyuki; c/o TAKEDA PHARMACEUT- TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, 2- ZA, ZM, ZW. (JP). AIDA, ICAL COMPANY LIMITED, 26-1, Muraoka-Higashi Fujisawa-shi, Kanagawa, 2510012 chome, c/o COMPANY (84) Designated States (unless otherwise indicated, for every Jumpei; TAKEDA PHARMACEUTICAL Fujisawa-shi, kind of regional protection available): ARIPO (BW, GH, LIMITED, 26-1, Muraoka-Higashi 2-chome, Hidekazu; c/o GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Kanagawa, 2510012 (JP). TOKUHARA, LIMITED, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TAKEDA PHARMACEUTICAL COMPANY Kanagawa, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, 26-1, Muraoka-Higashi 2-chome, Fujisawa-shi, TAKEDA DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, 2510012 (JP). OKAWA, Tomohiro; c/o 26-1, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, PHARMACEUTICAL COMPANY LIMITED, Muraoka-Higashi 2-chome, Fujisawa-shi, Kanagawa, [Continued on next page] (54) Title: HETEROCYCLIC COMPOUND O N (I) ,—, n 0 ) © X © Ra ,—, ,—, R b IN ,—, IN 1-1 (57) : The present invention provides a compound having an MAGL inhibitory action, and useful as an agent for the pro - 0 phylaxis or treatment of neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotroph- iclateral sclerosis, traumatic brain injury, glaucoma, multiple sclerosis etc.), anxiety disorder, pains (e.g., inflammatory pain, cancer - \" C ous pain, neurogenic pain etc.), epilepsy, depression and the like. The present invention relates to a compound represented by the formula (I) : wherein each symbol is as defined in the specification, or a salt thereof. WO 2017/171100 Al 1#11101M01101DEIROIDEOM0101101010101101 II 0VOIS SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). with sequence listing part of description (Rule 5.2(a)) Published: — with international search report (Art. 21(3))