baber/WOPTO huggingface dataset:
Patent JP-2003181027-A (JP)
Title: Game machine
Inventor: TAKAYAMA IKURO
IPC: A63F7/02
Filed: 2001-12-17
Abstract: <P>PROBLEM TO BE SOLVED: To provide a game machine which can generate sounds for advance notices without degrading attractiveness.  <P>SOLUTION: The advance notice sound B1 for showing lower probability of attaining ready for win positions eventually leading to big wins, the advance notice sound C1 for medium probability and the advance sound C1 for higher probability are equal in the quality of sounds with the same frequency f1 from the time t0 to the specified time t2 and after the time t21 passes, the frequency f varies with the passage of the time T. In other words, the advance notice sound A1 maintains the frequency f1 despite the passage of the time, the advance notice sounds B1 and C1 are multiplied in the frequency f with the passage of time after the specified time t2 passes and the frequency of the advance notice sound C1 increases at a greater rate as compared with the advance notice sound B1. Thus, players can not judge expected values given by the advance notice sounds before the time t21 passes to allow the players to keep concentrations on their games longer thereby enhancing their interests in games.  <P>COPYRIGHT: (C)2003,JPO
Patent JP-2003183113-A (JP)
Title: Composition for external use
Inventor: SAKIHARA NAGAHIRO
IPC: A61K8/00
Filed: 2001-12-18
Abstract: <P>PROBLEM TO BE SOLVED: To obtain a composition for external use which contains 1,2- pentanediol and hinokitiol and is remarkably excellent in safety, usability, and retention of efficacy.  <P>SOLUTION: This composition for external use contains 1,2-pentanediol and hinokitiol.  <P>COPYRIGHT: (C)2003,JPO
Patent JP-2003184312-A (JP)
Title: Erection piece
Inventor: SAWABE SHIGEKATSU
IPC: E04B1/24
Filed: 2001-12-18
Abstract: <P>PROBLEM TO BE SOLVED: To provide erection pieces capable of quickly carrying out positioning work for connecting both up and down steel pipe columns with high degree of accuracy and quickly finishing crane work.  <P>SOLUTION: The erection pieces 13 and 10 are formed by projecting up and down steel pipe posts respectively to the outside in the vicinity of the connected end face of the up and down steel pipe posts 4 and 1 for connecting them to each other, and the erection pieces 13 and 10 are so formed that the upper end 10a of the erection piece 10 of the lower steel pipe post 1 is projected upward from the upper end face 1a of the lower steel pipe post 1 and that the lower end 13a of the erection piece 13 of the upper steel pipe post 4 is located upward from the lower end face 4a of the upper steel pipe post 4 by corresponding to the erection piece 10.  <P>COPYRIGHT: (C)2003,JPO
Patent JP-2003187578-A (JP)
Title: Semiconductor memory and refresh control method
Inventor: NATSUI SHUN
IPC: G11C11/408
Filed: 2001-12-19
Abstract: <P>PROBLEM TO BE SOLVED: To realize specifications of external 8 kref/internal 4 kref without destroying stored data and without lengthening a time tRFC for refresh operation of one time.  <P>SOLUTION: First, it is prevented that replacement by a redundant word line is performed by making a redundant non-access signal 102 active, two normal word lines which do not belong the same mat are successively selected and activation is performed simultaneously, next, it is prevented that activation of a normal word line is performed by making a redundant access signal 101 active, two normal word lines which do not belong the same mat are successively selected and activation is performed simultaneously. As it is prevented that replacing a normal word line by a redundant word line is performed and refresh of a normal word line and refresh of a redundant word line are performed respectively, two word lines in the same mat never be activated simultaneously even if refresh of two word lines is performed by a refresh command of one time.  <P>COPYRIGHT: (C)2003,JPO
Patent JP-2002252864-A (JP)
Title: Positional information converter, positional information converting method, recording medium and program
Inventor: TATEISHI HIROMI
IPC: H04W88/18
Filed: 2001-12-21
Abstract: PROBLEM TO BE SOLVED: To convert information into suitable position information, according to the size of a radio zone covered by a base station. SOLUTION: The apparatus comprises a position information level-determining unit 204 for determining one or more levels about position information hierarchically set to two or more levels, according to the size of a radio zone covered by a base station and a position information converter 206 for converting base station information of the base station into position information of one or more levels determined according to the level-determining unit 204. Thus the position information can be provided in view of the area (plane), unlike the conventional position information providing service which could provide positional information of one point only.
Patent JP-2003184380-A (JP)
Title: Unlock device
Inventor: SUEOKA KAZUHIKO
IPC: B60R25/04
Filed: 2001-12-25
Abstract: <P>PROBLEM TO BE SOLVED: To promote reducing the size of an unlock device and power consumption.  <P>SOLUTION: The device comprises an antenna 31 that receives a first signal with a slow transmission speed and a second signal with a fast transmission speed, a receiver 38, a filter 41, a comparator 42, a decoder 43, a filter 44, a comparator 45 and a decoder 46. The receiver 38 receives both the first and second signals, and the decoders 43 and 46 process them by a single microcomputer 49 and give a processing output from an output terminal 48. This method can reduce the size of unlock device and power consumption.  <P>COPYRIGHT: (C)2003,JPO
Patent JP-2003191653-A (JP)
Title: Intermediate transfer recording medium
Inventor: AKIYAMA KEIICHI
IPC: B41M5/382
Filed: 2001-12-25
Abstract: <P>PROBLEM TO BE SOLVED: To provide an intermediate transfer recording medium capable of improving heat resistance, wear resistance and solvent resistance or the like of images recorded on a retransferred recording medium.  <P>SOLUTION: The intermediate transfer recording medium 1 is equipped with a substrate 1a and a resin film 1b formed on one face of the substrate 1a. Since the resin film 1b is composed of a UV curing layer using at least a UV curing resin and a photoinitiator as main constituents, images recorded on the retransferred recording medium 11 can be covered with a UV curing film cured by ultraviolet rays to become strong against mechanical strength or the like by covering an ink pattern retransferred to the retransferred recording medium 11 with the resin film and irradiating the resin film with the UV rays.  <P>COPYRIGHT: (C)2003,JPO
Patent JP-2003191586-A (JP)
Title: Target mark printing method and target mark printer
Inventor: YAMAMOTO HIROYUKI
IPC: B41K1/32
Filed: 2001-12-26
Abstract: <P>PROBLEM TO BE SOLVED: To provide a target mark printing method for printing a target mark for measuring paper feed quantity without using a printer or the like and changing the original characteristics of paper, and a target mark printer.  <P>SOLUTION: The target mark for measuring paper feed quantity is printed on paper at a desired position using a penetration type rotary stamp while rotating the same.  <P>COPYRIGHT: (C)2003,JPO
Patent JP-2003194097-A (JP)
Title: Gear fall preventing mechanism for transmission
Inventor: IUMA AKIHIRO
IPC: F16H3/08
Filed: 2001-12-26
Abstract: <P>PROBLEM TO BE SOLVED: To provide the compact structure capable of preventing a gear fall of a clutch slider and capable of selecting multi-stage speed without increasing the operating force when shifting in a transmission.  <P>SOLUTION: A hub 46 is provided with a male spline 42x of a first free rotating gear 42 in one axial directional end thereof, and provided with a female spline 43x of a second free rotating gear 43 in the other axial directional end thereof. A female spline 47y of a clutch slider 47 to be fitted to a male spline 46x of the hub 46 is provided with a first claw part 111 and a second claw part 112. In any of the first condition that the clutch slider 47 connects the first free rotating gear 42 to a rotary shaft 41 and the second condition that the clutch slider 47 connects the second free rotating gear 43 to the rotary shaft 41, one of the claw parts 111 and 112 is brought in contact with a taper part P tapered toward one side in the axial direction of the male spline, and the other of the claw parts 111 and 112 is brought in contact with a taper part Q tapered toward the other side in the axial direction of the male spline.  <P>COPYRIGHT: (C)2003,JPO
Patent JP-2003196745-A (JP)
Title: System and method for managing sales price, computer readable recording medium with program recorded thereon and program
Inventor: TOMONO MASASHI
IPC: G06Q10/00
Filed: 2001-12-27
Abstract: <P>PROBLEM TO BE SOLVED: To provide technology for automatically discriminating update timing of a sales price and updating a set price into a discount price in relation to a sales price management system for updating a PLU (price look up) table that stores the sales price of merchandise.  <P>SOLUTION: A set price/discount price judging part 102 judges whether to use a discount price in each merchandise managed by the PLU table 101 on the basis of a set price maintaining condition stored in a magazine database 103. If it is decided that the discount price is used, a discount price setting part 105 calculates a discount price with a discount rate defined in each publishment form of a magazine and the discount price in the PLU table 101.  <P>COPYRIGHT: (C)2003,JPO
Patent JP-2003194812-A (JP)
Title: Micro-array and measuring method using this micro-array
Inventor: SAKAI TAKUMA
IPC: C12N15/09
Filed: 2001-12-27
Abstract: <P>PROBLEM TO BE SOLVED: To provide a micro-array for improving quantitatively determining performance in a measuring method using the micro-array, and the measuring method using this micro-array.  <P>SOLUTION: This measuring method uses the micro-array, and is constituted so as to specify a unknown sample by determining the concentration of the unknown sample by applying a labeling quantity to an analytical curve by after being obtained by measurement after labeling and adding the unknown sample to a ligand by using the analytical curve expressed by a labeling quantity to the concentration of a reference obtained by labeling, adding, and hybridizing the complementary reference to the ligand arranged and fixed in a plurality on the micro-array in plural kinds of concentration.  <P>COPYRIGHT: (C)2003,JPO
Patent JP-2002346346-A (JP)
Title: Filter, method for cleaning filter, filtration apparatus and power generation plant
Inventor: FUJIE MAKOTO
IPC: C02F1/44
Filed: 2001-12-27
Abstract: PROBLEM TO BE SOLVED: To reduce elution from a filter and to prevent the breakage of the filter by a heat cycle and the lowering of water permeation performance. SOLUTION: The filter 7 of a fluorocarbon resin for filtering suspended solids in water is heat-treated in air or in liquid at a temperature of the melting point of the fluorocarbon resin or below before being used. Alternatively, the filter is subjected to fluid permeation treatment by hot water or gas.
Patent JP-2003214315-A (JP)
Title: Device and method of generating hydraulic power
Inventor: SAKATANI MIYUKI
IPC: F03B17/02
Filed: 2001-12-28
Abstract: <P>PROBLEM TO BE SOLVED: To obtain a device of generating hydraulic power that generates high power with low cost of equipment and generates pollution-free power, by converting mechanical energy to potential energy efficiently to generate power.  <P>SOLUTION: This device 100 of generating hydraulic power includes a hydraulic power generator 11 that operates by potential energy of water falling, a head tank 7 that is positioned above the generator 11 and that supplies water 4 to the generator 11, a water reservoir 6 that is positioned below the generator 11 and stores a predetermined amount of water 5, and pumping means 1 provided between the reservoir 6 and the tank 7. The pumping means 1 includes a pumping body 2 that reciprocates between the reservoir 6 and the tank 7, and a plumbing body 3 that reciprocates in the direction different from that of the pumping body 2. The plumbing body 3 is so configured that its mass varies according to the operation of the pumping body 2.  <P>COPYRIGHT: (C)2003,JPO
Patent JP-2003165116-A (JP)
Title: Method and apparatus for drawing tire cord of waste tire
Inventor: YAMASHITA RIKIO
IPC: B60C19/00
Filed: 2001-11-29
Abstract: <P>PROBLEM TO BE SOLVED: To solve the problem that when the waste tire of an automobile or the like is heretofore treated as a waste, the tire cord made of a steel has a strong strength and further a high hardness, hence the tire cord is unsuited for a cutting treatment, and even when the tire cord is crushed, it is necessary to very finely crush the cord so as to separate a synthetic rubber and the tire core, and accordingly a technique for simply drawing the tire cord is necessary.  <P>SOLUTION: The method for drawing the tire cord of the waste tire comprises the steps of inserting a cylinder 1 having a pawl 2 into the bore of a tire 12, engaging the tire cord 18 while the synthetic rubber of the tire 12 is cut and torn by the pawl 2, drawing off the tire cord 18 from the synthetic rubber of the tire 12, then further rotating the cylinder 1, and winding the tire cord to draw the tire cord from the tire 12.  <P>COPYRIGHT: (C)2003,JPO
Patent JP-2003501496-A (JP)
Title: エチレン重合及び共重合用触媒
IPC: C08F4/656
Filed: 1999-10-23
Abstract: (57)【要約】
本発明はエチレン重合または共重合用触媒成分に関するものであって、より詳しくはハロゲン化マグネシウム化合物とアルコールとを接触反応させマグネシウム溶液を製造し、ここに少なくとも一つのヒドロキシ基を含むエステル化合物とアルコキシ基を有するシリコン化合物を反応させた後、チタニウム化合物とシリコン化合物の混合物を反応させて製造されるエチレン重合及び共重合用固体錯物チタニウム触媒に関するものである。本発明の触媒は高活性であり、水素反応性が非常に優れた長所を有する。
Patent JP-2003502671-A (JP)
IPC: C12Q1/26
Filed: 2000-06-16
Abstract: A method for determining concentration of an analyte in a biological sample comprising the steps of: (a) combining the biological sample, at least one oxidizing enzyme for the analyte of interest, nicotinamide adenine dinucleotide (hereinafter NAD+), and a chemiluminescent label to form a reaction mixture; (b) allowing the analyte to undergo an oxidation-reduction reaction and NAD+ to be converted to the reduced form of nicotinamide adenine dinucleotide (hereinafter NADH) and further allowing the chemiluminescent label to react with NADH; and (c) determining the concentration of the analyte of interest in the biological sample by correlating the quantity of light emitted with the concentration of NADH.
Patent JP-2003503537-A (JP)
IPC: C09D11/00
Filed: 2000-06-19
Abstract: A compound of formula (1), and compositions containing a plurality of such compounds, wherein, independently at each occurrence, R1 is a linear alkyl group having at least twenty carbons; R2 is selected from the diradical that results when two carboxyl groups are removed from polymerized fatty acid, and a linear C4-12 hydrocarbon group, with the proviso that at least one occurrence of R2 is the diradical that results when two carboxyl groups are removed from polymerized fatty acid; R3 is a diradical selected from C2-36 hydrocarbons and C4-30 poly(alkyleneoxides); X is selected from O and NH such that X-R3-X is selected from O-R3-O and NH-R3-O; and n represents a number of repeating units selected from 1-5, may be used as a vehicle for hot melt printing inks, including inks for ink jet printing.
Patent JP-2003522734-A (JP)
Title: 銀、銅、又は亜鉛イオンにより効力増大したピリチオン殺生物剤
IPC: A01N59/26
Filed: 2000-06-23
Abstract: (57)【要約】
本発明は、ピリチオン又はピリチオン錯体；及び亜鉛又は銅又は銀の塩、酸化物、水酸化物、硫酸塩、塩化物、金属、及びそれらの組合せからなる群から選択された亜鉛又は銅又は銀源を含有し、然も、前記亜鉛又は銅又は銀源対ピリチオン又はピリチオン錯体の重量比が約１：３００〜約５０：１の範囲にあり、種々の自生微生物又はバイオフイルムに対し増大した殺生物効果を有する抗菌組成物に関する。前記抗菌組成物を用いて自生微生物又はバイオフイルムの増殖を阻止する方法のみならず、燃料、流体、潤滑剤、被覆、接着剤、密封材、エラストマー、石鹸、化粧品、プラスチック、又は織った又は不織繊維、医薬を含めた種々の製品中に、また前記製品のための保存剤として前記抗菌組成物を使用することも記載されている。
Patent JP-2003503777-A (JP)
IPC: G06F9/445
Filed: 2000-06-23
Abstract: A method is proposed for operating a portable data carrier designed for executing reloadable function programs. According to the method the data carrier initially has installed thereon a loader interface which allows the reloading of load applications which in turn permit the loading of function programs. Each load application has allotted thereto an invariable assigned address space. To support the management of an assigned address space, badges are produced for application programs to be reloaded, said badges containing information about the size of the memory space required for the application program. Address space in the memory device is allotted to application programs to be reloaded in accordance with the size information provided on the badges. A data carrier suitable for carrying out said method is further disclosed.
Patent JP-2003505085-A (JP)
IPC: C12N15/09
Filed: 2000-06-29
Abstract: A pyrF gene is useful as a selection marker gene for an expression system for the production of proteins in mushrooms of the genus Trametes, Coriolus or Polyporus. The pyrF gene includes a DNA sequence SEQ ID NO: 1 from position 1133 up to and including position 1877 or DNA-sequence SEQ, ID NO: 2 from position 1 up to and including position 684 or a DNA-sequence with a sequence homology greater than 60% relative to the above-mentioned regions of sequence SEQ ID NO: 1 or SEQ ID NO: 2.
Patent JP-2003505266-A (JP)
Title: モジュラーグリッパー
IPC: F16B7/18
Filed: 2000-05-02
Abstract: (57)【要約】
このモジュラーグリッパーは、産業界における全てのタイプの金属、ボール紙、ガラス、或いは、木材の材料を搬送するのに用いられる。数種類のアルミニウム型材、並びに、その形状のために迅速に取付け可能で、且つ、搬送したい部品の全ての形状に対処可能な数種類の軽合金製機械部品で構成されている。この発明は、特に、産業界における全てのタイプの金属、ボール紙、ガラス、或いは、木材の材料をグリップすることを目的にしている。
Patent JP-2003507625-A (JP)
Title: 形状記憶合金アクチュエータおよび制御方法
IPC: F03G7/06
Filed: 2000-08-11
Abstract: (57)【要約】
本発明は、顕著な力低下なしにストローク増大化を与え、容易にミニチュア化可能であり、高速作動であるストローク増大化形状記憶合金アクチュエータおよび電気機械的能動性材料を用いる他のアクチュエータ（本出願において、集合的にＳＭＡアクチュエータという）、およびそれらのデザインおよび使用；低電力消費、抵抗／障害／負荷感知および正確な位置制御用の（従来の形状記憶合金アクチュエータならびに本発明のストローク増大化アクチュエータを含む）形状記憶合金アクチュエータについての経済的、効率的な制御および感知メカニズム；およびこれらのアクチュエータを含有するデバイス、および制御および感知メカニズムを提供する。
Patent JP-2003508365-A (JP)
IPC: C07C63/38
Filed: 2000-08-08
Abstract: An oxidation free process for converting a hydroxy substituted aromatic to an aromatic diacid which comprises reacting a hydroxy substituted aromatic with excess basic salt in the presence of carbon dioxide at disproportionation/isomerization reaction conditions.
Patent JP-2003512425-A (JP)
Title: ６−メトキシ−２−ナフチル酢酸プロドラッグ
IPC: A61K31/167
Filed: 2000-10-27
Abstract: (57)【要約】
本発明は、治療として有効な量の６ＭＮＡプロドラッグを提供する。この医薬組成物は（１）を含んでなり、式中、ＲはＨとＣＯＲ’とからなる群から選ばれ、Ｒ’はＣ 1 からＣ 6 までのアルキル、（ＣＨ 2 ） m Ｏ（ＣＨ 2 ） n 、（ＣＨ 2 ） m （ＯＣ 2 Ｈ 4 ） p Ｏ（ＣＨ 2 ） n 、（ＣＨ 2 ） m （ＯＣ 2 Ｈ 4 ） p 、（ＯＣＨ 2 Ｈ 4 ） p ＯＮＯ 2 及び（ＯＣＨ 2 Ｈ 4 ） p Ｏ（ＣＨ 2 ） n からなる群から選ばれ、ｍは２から４までの整数であり、そしてｎとｐは１から４までの整数である。あるいは、Ｒは治療性の部分である。
Patent JP-2003512073-A (JP)
IPC: C12N5/10
Filed: 2000-10-27
Abstract: Recombinant Escherichia coli host cells that comprise recombinant DNA expression vectors that drive expression of methylmalonyl CoA mutase from Propionibacterium shermanii or Streptomyces cinnamonensis as well as Propionibacterium shermanii epimerase can produce S-methylmalonyl CoA, a required substrate for the production of polyketides by most modular polyketide synthases not present in wild-type E. coli host cells.
Patent JP-2003515419-A (JP)
IPC: A61B5/01
Filed: 2000-12-01
Abstract: The invention estimates a cardiac performance value such as cardiac output (CO) and cardiac ejection fraction (EF) by sensing a downstream indicator concentration signal y(t) that corresponds to an indicator (preferably heat) signal x(t) injected upstream in a patient's blood channel. The signal x(t) is preferably generated as a series of alternating transitions between a high state and a low state, such as a PRBS signal. The signal y(t) is then divided into at least one sub-signal that is synchronous with x(t). A decay parameter τ that minimizes a cost function that includes a time-domain channel relaxation model is then calculated. The cardiac performance value is then calculated based on this value for τ. For each transition of the injected indicator signal, a corresponding segment of the indicator concentration signal is preferably isolated, and a segment relaxation parameter is then calculated. The decay parameter τ is then estimated as a predetermined function of the segment relaxation parameters. In embodiments of the invention in which x(t) is periodic, the invention also generates estimates of τ by finding the minimum of a cost function between a model of the channel and an average of several cycles of y(t), each corresponding to one period of x(t).
Patent JP-2003516668-A (JP)
Title: チャネル評価を変換する方法及びシステム
IPC: H04L25/02
Filed: 2000-11-27
Abstract: (57)【要約】
チャネル評価が受信信号に対して実行される。ここでは、その受信信号の異なる部分が異なる変調タイプを用いて変調される。そのチャネルはまず、第１の変調タイプで変調された受信信号の部分に基づいて評価される。このチャネル評価はそれから、少なくとも第２の変調タイプに対応するチャネル評価へと変換される。
Patent JP-2003517668-A (JP)
IPC: G05B9/02
Filed: 2000-12-14
Abstract: Methods and systems for fail-safe process execution, monitoring and output control for critical systems operating on an open bus architecture with multiple, independent partitions on a single processor is presented. The control system state variables and their status of critical systems, within the control laws and mode logic, are monitored for process completion and health, and shut down if necessary. The embodiments provide for a dual path for shut down of, for example, flight critical systems so that the failure of one partitioned module does not affect the operation of the remaining partitioned modules. One path involves the CPM and IOM determination of command/response health. If persistent faults are detected, then either the DSP monitoring or the CPM performance monitoring results in a discrete signal being sent to the H-bridge disable to shutdown the current output. The second path is CPM controlled via a separate discrete signal on the input/output controller to the flight critical system shut-off valve. By implementing these separate paths, critical systems in one partition cannot be defeated by a single failure in another partition.
Patent JP-2003519161-A (JP)
IPC: A01N43/48
Filed: 2000-05-24
Abstract: The present invention relates to stabilized isothiazolone compositions and methods of stabilization of isothiazolone, more particularly, to stabilized isothiazolone solutions comprising (a) an isothiazolone composition, (b) sulfuric acid, and (c) solvent.
Patent JP-2003520000-A (JP)
Title: 移動ネットワークにおいてサービスのアドレス発見を提供するシステム及び方法
IPC: H04W4/00
Filed: 2000-12-18
Abstract: (57)【要約】
本発明は、アプリケーション・サービスへアクセスするアドレスを移動端末装置（１２）に提供する方法及びネットワークである。本発明のネットワークは、ネットワーク（１００，２００）を介して伝送される情報を送受信する複数の移動端末装置と、前記複数の移動端末装置によりアクセス可能であり、前記移動端末装置にサービスを提供する前記ネットワークに結合された少なくとも１つの記憶装置（５２）と、前記複数の移動端末装置に結合されたディレクトリ記憶装置（１０２）とを含んでおり、前記ディレクトリ記憶装置は、前記少なくとも１つの記憶装置のアドレスを蓄積すると共に、前記移動端末装置のうちの少なくとも１つに、前記少なくとも１つの記憶装置の少なくとも１つのアドレスを通信メッセージに応答して提供し、前記複数の端末装置は前記少なくとも１つの記憶装置と通信してそれからサービスを取得する。
Patent JP-2003527370-A (JP)
IPC: C07C315/02
Filed: 2001-03-08
Abstract: The present invention relates to a procedure for the oxidation of a thioether group to a sulfoxide group, with aqueous sodium percarbonate in the presence of a molybdenum salt as a catalyst. The procedure is of application to oxidize the thioether group of a compound (I), where R1 is a C1-C6 alkyl, a halogenated C1-C6 alkyl, or -(CH2)n-OR9, where n is an integer between 1 and 6 and R9 is H or a C1-C6 alkyl; R2, R3, R4, R5, R6 and R8, independently form each other represent H, a C1-C6 alkyl, or C1-C6 alkoxy; and R7 is H, a C1-C6 alkyl, a C1-C6 alkoxy or a C1-C6 fluorinated alkoxy, in order to obtain the sulfinyl derivative (II). <CHEM>
Patent JP-2003527412-A (JP)
Title: 安定化された乾燥粉末製剤
IPC: A61K31/075
Filed: 2001-03-13
Abstract: (57)【要約】
吸入による肺症状処置用の乾燥粉末製剤を提供する。これは有効量の、乾燥粉末型のフォルモテロールまたはその塩もしくは溶媒和物、有効量の、乾燥粉末型フルチカソン、および賦形剤を含むものである。物理的に安定な吸入用乾燥粉末製剤の製造方法を提供する。この方法は第一の極性活性薬物、第二の非極性活性薬物、および極性賦形剤を微粉化する工程を含む。第二の非極性活性薬物をまず賦形剤と混合し、中間混合物を形成させる。次いでこの中間混合物を第一の極性活性薬物と混合する。極性薬物と極性賦形剤の分離が増大し、製剤が安定化される。