baber/WOPTO huggingface dataset:
Patent WO-2020198031-A1 (WO)
Title: Lung cancer specific marrow infiltrating lymphocytes and uses thereof
Inventor: NOONAN KIMBERLY
IPC: A61P31/10
Filed: 2020-03-20
Abstract: Lung cancer specific marrow infiltrating lymphocytes ("MILs") and methods for making and using the same are described. Disclosed herein is a method for treating a subject having lung cancer with marrow infiltrating lymphocytes, the method comprising the steps of: (a) culturing a bone marrow sample obtained from the subject having lung cancer with an anti-CD3 antibody and an anti-CD28 antibody in a hypoxic environment to produce hypoxic-activated marrow infiltrating lymphocytes; (b) culturing the hypoxic-activated marrow infiltrating lymphocytes in a normoxic environment to produce the therapeutic activated marrow infiltrating lymphocytes; and (c) administering the therapeutic activated marrow infiltrating lymphocytes to the subject having lung cancer.
Patent WO-2020198331-A1 (WO)
Title: Various structured supports for 3d printed aligners/mouth pieces
Inventor: CHAVEZ JENNIFER
IPC: B29C64/188
Filed: 2020-03-25
Abstract: A support is coupled to an appliance to decrease warpage. The support may comprise a plurality of extensions coupled to the appliance to decrease warpage. The extensions can be coupled to the appliance at one or more of many locations, such as on an occlusal surface, a wall, an edge or an interior of the appliance. In some embodiments, the extensions are coupled to walls of the appliance such as a buccal wall and a lingual wall, and the extensions can be coupled to the walls of the appliance near edges of the walls, such as a gingivally facing edges of the walls that are oriented toward the gingiva when the appliance is worn.
Patent WO-2020210279-A1 (WO)
Inventor: BROCA VICTOR-BENJAMIN
IPC: G06Q50/12
Filed: 2020-04-08
Abstract: A method for processing a customer food order in a multi-kitchen environment, including receiving an order having at least first and second food items, translating an identifier of the first food item to a first corresponding identifier associated with a first kitchen and routing the first corresponding identifier to the first kitchen, translating an identifier of the second food item to a second corresponding identifier associated with a second kitchen and routing the second corresponding identifier to the second kitchen, receiving a notification that the first food item is located at one of a plurality of delivery storage locations, and receiving a notification that the second food item is prepared for storage, and in response transmitting the delivery storage location of the first food item.
Patent WO-2020210296-A1 (WO)
Inventor: KARUMBAIAH LOHITASH
IPC: G01N33/50
Filed: 2020-04-08
Abstract: Described herein is a microfluidic assay device that mimics  in vitro  the  in vivo  biological environment, supporting endothelization, allowing for perfusive flow similar to  in vivo  blood flow conditions, and providing for realistic interactions between T-cells and solid tumor cells, such as glioblastoma multiforme tumor cells. Also described herein are methods of using this microfluidic assay device for the study of interactions of immune cells with tumor cells, such as glioblastoma multiforme tumor cells, and the development of improved immunotherapeutic approaches against cancers, such as glioblastoma multiforme.
Patent WO-2020210367-A1 (WO)
Title: Ph-responsive silica metal organic framework nanoparticles for delivery of bio active molecules
Inventor: GONG SHAOQIN
IPC: A61K38/12
Filed: 2020-04-08
Abstract: Provided herein are silica metal organic framework (SMOF) nanoparticles that are pH- responsive for delivery of bioactive molecules. The nanoparticles include a organosilica network comprising a plurality of imidazolyl and/or carboxyl groups; a metal organic framework component comprising a transition metal coordinated to a coordinating ligand, wherein the transition metal is selected from the group consisting of zinc, iron, zirconium, copper, and cobalt, and the coordinating ligand is selected from an imidazolate ligand or a carboxylate ligand; a bioactive payload selected from the group consisting of a hydrophilic drug, a polynuclei c acid, a protein and a protein-polynucleic acid complex; and a surface-modifying polymer conjugated to the same or a different organosilica network and forming at least part of an exterior surface of the nanoparticle, wherein the surface-modifying polymer is selected from polyethylene glycol and/or a polyzwitterion; and wherein the zinc also coordinates the imidazolyl or carboxyl group of the organosilica network.
Patent WO-2020210781-A1 (WO)
Title: Engineering a naturally-derived adhesive and conductive cardio-patch
Inventor: ANNABI NASIM
IPC: H01B1/12
Filed: 2020-04-13
Abstract: The present invention relates to adhesive and electroconductive cardiopatches designed to provide mechanical support and restore electromechanical coupling at the site of MI to minimize cardiac remodeling and preserve normal cardiac function.
Patent WO-2020214801-A1 (WO)
Inventor: CLARK ANTHONY J
IPC: A61K36/062
Filed: 2020-04-16
Abstract: Disclosed is a composition comprising a combination of at least one flavor compound and a taste-modulating portion of a filamentous fungus mycelial aqueous culture, e.g. a mycelia is from a  Cordyceps  spp, where the flavor compound is a combination and sodium chloride and potassium chloride and when combined with food, beverage or other product, reduces metallic and/or bitter taste resulting from the presence of KCl and provides an extended "salt" flavor perception in the product. The flavor compound can also include at where the at least one flavor compound is a bitterness blocker or a bitterness masker, wherein the combination is capable of synergistically reducing bitter tastes or reducing aftertastes of a food, beverage, or other product. Methods to enhance the taste of a food, beverage or other product using the flavor compounds and taste-modifying portions of a filamentous fungus are also disclosed.
Patent WO-2020226922-A1 (WO)
Title: System for optical wash item recognition in dishwashers, method for optical wash item recognition, dishwasher with an optical wash item recognition system and method for operating such a dishwasher
Inventor: DISCH HARALD
IPC: A47L15/00
Filed: 2020-04-27
Abstract: A system for optical wash item recognition for commercial dishwashers (1) embodied in particular as conveyor dishwashers or as automatic programme dishwashers, in particular hood dishwashers, wherein the system includes an optical recognition system (51), especially a camera, for recording at least one two-dimensional image of at least some of the wash items to be treated in the dishwasher (1). The system also includes an analysis device (52) for analysing at least one recorded image in such a way that individual wash items or groups of individual wash items in the recorded image are located and classified. According to the invention, it is in particular provided that at least one neural network will be used to analyse the at least one recorded image.
Patent WO-2020223339-A1 (WO)
Inventor: KIM YONG-CHUL CHARLES
IPC: G06F3/00
Filed: 2020-04-29
Abstract: The present invention is directed to an electronic system for the assessment of emotional state. The system allows individual employees to specify their emotions using a set of emojis. The system provides a graphical user interface that displays a list of different emotions and associated emojis that the user can select. The system allows the user to write an entry about his thoughts and emotions in conjunction with the selected emojis and send the message with the emojis to individuals with whom he chooses to share. The system provides a list of company-wide employees from which the user can select. The system receives the messages and implements data structures to process the received messages and produce individual and company-wide emotional state information.
Patent WO-2020231743-A1 (WO)
Inventor: WANG GANG
IPC: H04L29/06
Filed: 2020-05-07
Abstract: At least one aspect is directed to improving performance of a data processing system processing content item operations by identifying fraudulent content item operations. The data processing system can receive a content item operation including a content item device identifier and an attestation token from a client device. The attestation token can include a public key associated with the computing device, an attestation token time stamp, a message payload, and an embedded digital signature. The data processing system can verify a digital signature of a combination of the public key, the attestation token time stamp, and the message payload using the public key as a signature verification key. The system may process the content item operation only if the digital signature verification process succeeds.
Patent WO-2020227554-A1 (WO)
Title: Methods of making antibodies
Inventor: JOSHI KAMAL KISHORE
IPC: C07K16/28
Filed: 2020-05-07
Abstract: Provided are,  inter alia , methods of improving pairing of a heavy chain and a light chain of an antibody (such as a bispecific antibody). Also provided are antibodies (e.g., bispecific antibodies) generated using such methods, libraries, and methods of screening such libraries.
Patent WO-2020237007-A1 (WO)
Title: Dispensing system
Inventor: HEINBUCH KARL ALAN
IPC: B65D47/24
Filed: 2020-05-21
Abstract: A dispensing fitment assembly includes a fitment assembly and a dispensing probe. The fitment assembly includes a fitment housing and a plug. The fitment housing is configured to operatively couple to a container opening of a fluid container. The plug is positioned within an interior portion of the fitment housing. The plug is slidingly movable between an open and closed position. Engagement between the dispensing probe and the interior surface of the plug is configured to move the plug from the closed position to the open position. Disengagement between the dispensing probe and the interior surface of the plug is configured to move the plug from the open to closed position.
Patent WO-2021076195-A1 (WO)
Inventor: DING KEJIA
IPC: H01Q25/00
Filed: 2020-05-29
Abstract: Systems and methods relating to multi-beam forming networks using an antenna array. A matrix circuit for feeding elements of an antenna array to produce multiple beams is provided. To address beam squint issues, beam squint is mitigated by using a series of phase shifters with specific phase-delay performances between the matrix circuit and the antenna array elements. A linearly increasing or decreasing phase difference in the signals fed into adjacent antenna array elements across the array mitigates or eliminates beam squint in the resulting multiple beams. The phase shifters are programmed to provide this increasing or decreasing phase differences.
Patent WO-2020247919-A1 (WO)
Title: Système de modification de contenu ayant une caractéristique d'utilisation d'un calendrier de diffusion
Inventor: GROVER MATTHEW GEORGE
IPC: H04N21/266
Filed: 2020-06-08
Abstract: Selon un aspect, l'invention concerne un procédé qui consiste : (i) à accéder à des données de calendrier de diffusion associées à un canal ; (ii) à utiliser les données de calendrier de diffusion accédées pour identifier une opportunité de modification de contenu à venir sur le canal ; (iii) en réponse à l'identification de l'opportunité de modification de contenu à venir sur le canal, à identifier un dispositif de présentation de contenu accordé sur le canal ; et (iv) à amener un contenu supplémentaire à être transmis au dispositif de présentation de contenu identifié, pour faciliter le dispositif de présentation de contenu identifié effectuant une opération de modification de contenu liée à l'opportunité de modification de contenu à venir identifiée sur le canal.
Patent WO-2021086448-A1 (WO)
Title: Encoding digital videos using controllers of data storage devices
Inventor: MUTHIAH RAMANATHAN
IPC: H04N19/44
Filed: 2020-06-17
Abstract: In some embodiments, an apparatus includes a memory configured to store data and a controller coupled to the memory. The controller is configured to receive, from a computing device coupled to the apparatus, one or more frames of a digital video. The controller is also configured to analyze one or more components of the memory. The controller is further configured to determine a set of states for the one or more components of the memory based on the analysis of the one or more components of the memory. The controller is further configured to determine a first encoding rate for the digital video from a plurality of encoding rates based on the set of states for the one or more components of the memory. The controller is further configured to encode the digital video based on the first encoding rate and to store the encoded digital video in the memory.
Patent WO-2020264239-A1 (WO)
Inventor: PATEL RAKESH
IPC: A61K31/198
Filed: 2020-06-26
Abstract: The invention relates to methods for diagnosing or assessing the risk of developing chronic lung and bowel disease in pre-term infants by measuring the nitrate reductase activity in oral microbiome samples from the infant. The invention further relates to methods for guiding the care of pre-term infants based on measuring the nitrate reductase activity in oral microbiome samples from the infant.
Patent WO-2022005462-A1 (WO)
Title: Poly-donor cd4+ t cells expressing il-10 and uses thereof
Inventor: RONCAROLO MARIA
IPC: C07K14/725
Filed: 2020-06-30
Abstract: The present disclosure provides a population of poly-donor CD4 IL-10  cells generated by genetically modifying CD4 +  T cells from at least three different T cell donors. Further provided are methods of generating the poly-donor CD4 IL-10  cells and methods of using the poly-donor CD4 IL-10  cells for immune tolerization, treating GvHD, cancer, and other immune disorders.
Patent WO-2021016008-A1 (WO)
Title: Wafer cushion
Inventor: HARR COLTON J
IPC: H01L21/673
Filed: 2020-07-15
Abstract: Wafer cushions for use in wafer carriers include spring beams that include a first arm extending from the frame of the wafer cushion in a first direction and a second arm extending from the first arm in a second direction, and a wafer contact at the end of the second arm opposite where the second arm is joined to the first arm. The wafer cushion may contact a substrate within the wafer carrier only at the wafer contacts during normal conditions. The substrate may also contact secondary contact points on the second arm when a shock event occurs. The wafer contact can be v-groove style wafer contact. The wafer contact may include a contact surface having a convex surface where it is configured to contact the wafer.
Patent WO-2021040909-A1 (WO)
Title: Configured grants for sidelink communications
Inventor: FAKOORIAN SEYED ALI AKBAR
IPC: H04W76/14
Filed: 2020-07-20
Abstract: A first user equipment (UE) is configured to communicate with a second UE in sidelink communications using a sidelink configured grant (CG) configured by a base station. The first UE receives, a radio resource control (RRC) message or physical layer signaling including a sidelink configured grant (CG) configuration indicating at least some parameters configured by a base station for sidelink communications between the first UE and a second UE. The first UE transmits or receives a transport block for the sidelink communications on a physical sidelink shared channel (PSSCH) based on the at least some parameters.
Patent WO-2021016263-A1 (WO)
Title: Cysteine binding compositions and methods of use thereof
Inventor: HSU KU-LUNG
IPC: G01N33/68
Filed: 2020-07-21
Abstract: Purine-derived covalent probes (e.g., halo or di-halo-substituted purine based covalent probes) and related ligands are described. The compounds can be used to identify reactive nucleophilic amino acid residues, such as reactive cysteine residues, in proteins and to modify the activity of proteins with reactive nucleophilic amino acid residues (e.g., reactive cysteine residues) via the formation of protein adducts comprising the ligands. Modified proteins prepared from the probes and ligands are also described.
Patent WO-2021030044-A1 (WO)
Inventor: DVORSKY ANATOLY
IPC: A61F2/24
Filed: 2020-07-28
Abstract: An implantable prosthetic device comprises a frame comprising a first set of first struts and a second set of second struts. The first struts are pivotably connected to each other at a plurality of distal and proximal apices at distal and proximal ends of the frame. The second struts are pivotably connected to each other at a plurality of distal and proximal apices at the distal and proximal ends of the frame. The first struts have a first thickness, and the second struts have a second thickness, wherein the first thickness is greater than the second thickness. One or more actuators are coupled only to one or more corresponding pairs of a distal apex and a proximal apex formed by the first struts, wherein the one or more actuators are configured to apply axially directed forces to the frame to radially expand the frame.
Patent WO-2021030566-A1 (WO)
Inventor: FIELDS TIMOTHY
IPC: A47J19/02
Filed: 2020-08-13
Abstract: A masticating juicer includes an auger configured to rotate within a drum to perform a masticating process with respect to at least one food item introduced into the masticating juicer with the masticating process producing a juice and a pulp. An end cap is coupled to an end of the drum and is adjustable relative to the drum with respect to an axial direction of the auger. The end cap includes a flexible ring disposed adjacent an end of the auger formed from a resiliently flexible material configured to flex in reaction to the pulp applying pressure to the flexible ring. The flexing of the flexible ring increases a cross-sectional flow area between the auger and the flexible ring to accommodate a back pressure generated by the pulp.
Patent WO-2021034814-A1 (WO)
Title: Livestock health monitoring system and method of use
Inventor: GREER JOHN M
IPC: A61B5/00
Filed: 2020-08-18
Abstract: Systems and methods of using an animal wellness notification system to determine the wellness of an animal, the systems and methods comprising: attaching an animal wellness notification system component to an animal, monitoring the temperature of the animal to determine if the animal's temperature remains outside a selected temperature range for a selected time duration, and providing notice if the animal's temperature remained outside the selected temperature range for the selected time duration.
Patent WO-2021034953-A1 (WO)
Title: Compositions and related methods for the ablation of m2 macrophages and myeloid derived suppressor cells
Inventor: RALPH DAVID
IPC: A61K51/04
Filed: 2020-08-19
Abstract: Compositions and methods for ablating CD206 expressing macrophages and/or CD206 expressing myeloid derived suppressor cells (MDSCs) are disclosed. In certain aspects, disclosed methods comprise administering to a subject in need thereof an effective dose of a compound comprising a dextran backbone and one or more CD206 targeting moieties and one or more therapeutic agents attached thereto. In certain aspects, the therapeutic agent comprises a metal. In further aspects, the therapeutic agent comprises a cytotoxic agent.
Patent WO-2021035017-A1 (WO)
Title: Neuromodulation therapy monitoring and continuous therapy reprogramming
Inventor: PEPIN BRIAN MARC
IPC: A61N1/36
Filed: 2020-08-20
Abstract: Methods and systems are provided for updating neuromodulation-therapy algorithms. Sensor data may be received from a subject monitoring device that includes one or more sensors. A state of the subject within a directed-cyclic state diagram may be retrieved along with a current neuromodulation-therapy algorithm that corresponds to the state. Based on the sensor data and the current neuromodulation-therapy algorithm, a new state of the subject may be determined, the new state including an update to the current neuromodulation-therapy algorithm for the subject. In response to determining the new state, a wireless transmission that includes an identification of the new state and the update neuromodulation-therapy algorithm may be initiated to the implant device associated with the subject.
Patent WO-2021051011-A1 (WO)
Inventor: PAWLOSKY ANNALISA MARIE
IPC: C12N15/10
Filed: 2020-09-11
Abstract: La présente invention concerne des procédés et des compositions de séquençage d'une de protéines et peptides.
Patent WO-2021055931-A1 (WO)
Title: Smart dust cap
Inventor: TEMER ELIAS
IPC: E21B43/12
Filed: 2020-09-21
Abstract: A protective component for a downhole tool is described. The protective component incorporates a wireless networking circuit for communicating data retrieved by the downhole tool to a surface data repository. The protective component can include processing capabilities to allow the protective component to be peered with a downhole tool and to configure the downhole tool. The processing capabilities can include data processing, machine learning, and edge processing capabilities.
Patent WO-2021076423-A1 (WO)
Inventor: ACHARYA ANANTA
IPC: C12P19/34
Filed: 2020-10-09
Abstract: The disclosed embodiments concern methods for determining sequences of interest using targeted unique molecular index (TUMI) sequences that are uniquely associated with individual polynucleotide fragments in plants, such as those present in a transgenic event, a site-specific mutation or a wild type variant. System, apparatus, and computer program products are also provided for determining a sequence of interest implementing the methods disclosed.
Patent WO-2021076929-A1 (WO)
Inventor: VICE JACK
IPC: G05D1/00
Filed: 2020-10-16
Abstract: L'invention concerne un dispositif de mobilité multimodal à corps unique. Chaque patte du dispositif intègre une roue et un moteur de roue qui est soumis à un mouvement de direction à glissement. Lorsqu'une mobilité accrue est nécessaire, la came est mise en prise par le moteur de roue et un fil de tension intégré dans une ou plusieurs des pattes est soumis à une force pour comprimer et lever la patte. Une ou plusieurs pinces dans chaque patte sont prévues pour permettre une compression vers des parties spécifiques de la patte, ce qui permet des degrés de liberté semi-indépendants. Le dispositif utilise une intelligence artificielle (IA) à apprentissage par renforcement pour permettre des comportements autonomes. L'IA prend en compte les entrées d'état de l'environnement et les mappe à des sorties comprenant diverses actions de mobilité. Lors de la réalisation d'une action, le dispositif reçoit un signal de récompense proportionnel dirigé vers le renforcement de l'action.
Patent WO-2021101686-A1 (WO)
Inventor: ROHL JAMES P
IPC: A61B10/04
Filed: 2020-10-28
Abstract: A device includes a hollow needle with a lumen extending therethrough. The needle is sized and shaped to extend through an endoscopic shaft to a target tissue within a living body. The needle has a distal end with a sharpened distal tip for puncturing the target tissue and removing a portion of the tissue in the lumen. The device further includes a cylindrical stylet having a shaft sized and shaped to extend through the lumen of the needle and a distal end with a pointed distal tip for puncturing the target tissue. When the stylet is extended, the pointed distal tip of the stylet extends distally a predetermined distance past the sharpened distal tip of the needle.
Patent WO-2021097123-A1 (WO)
Title: Thiophene compounds with cyclic amides, and uses thereof
Inventor: GREEN MICHAEL JOHN
IPC: A61K31/435
Filed: 2020-11-12
Abstract: Provided herein are compounds comprising a four-ring core, such as compounds of Formula (I) and Formula (II), and pharmaceutically acceptable salts, solvates, tautomers, isotopes, or isomers thereof. Also provided herein are methods of inhibiting a component of the sterol regulatory element binding protein (SREBP) pathway, such as an SREBP or SREBP cleavage activating protein (SCAP), using these compounds, or pharmaceutically acceptable salts, solvates, tautomers, isotopes, or isomers thereof. Further provided are methods of treating a disorder in a subject in need thereof, such as liver disease, non-alcoholic steatohepatitis, insulin resistance, or cancer.