baber/WOPTO huggingface dataset:
Patent CR-20120551-A (CR)
Title: Mètodo para el tratamiento de un lìquido, en particular un aceite mineral
Inventor: DELGADO CASTILLO JOSE MIQUEL
IPC: B01F7/00
Filed: 2012-10-29
Abstract: Se describe un procedimiento para tratar un líquido, en particular un aceite mineral, para incrementar la porción de fracciones de bajo punto de ebullición.
Patent CR-20130028-A (CR)
Title: Formulaciones
Inventor: BELL GORDON ALASTAIR
IPC: C07C69/78
Filed: 2013-01-22
Abstract: La presente invención se refiere a una formulación que comprende un compuesto de fórmula (I) en donde R1 es hidrógeno, metilo, etilo, propilo o butilo; R2 es metilo o etilo; R3 es hidrógeno, metilo o etilo; y n es 1, 2 o 3; al uso de un compuesto de fórmula (I) como un disolvente; y a ciertos compuestos novedosos de fórmula (I).
Patent CR-20160388-A (CR)
Title: Terapias de combinación con anticuerpos anti-cd38
Inventor: DOSHI PARUL
IPC: C07K16/00
Filed: 2015-02-25
Abstract: La presente invención se refiere a terapias de combinación con anticuerpos anti-CD38.
Patent CR-20200641-A (CR)
Title: Substituted thiophenecarboxamides and analogues as antibacterials agents
Inventor: COQUERON PIERRE-YVES
IPC: C07D333/38
Filed: 2019-07-03
Abstract: <p>The present disclosure relates to substituted thiophene carboxamides and analogues thereof of formula (II) that may be used for protecting plants from bacterial diseases, in particular from bacterial diseases caused by bacteria belonging to the genus Xanthomonas.</p>
Patent CR-20210599-A (CR)
Inventor: FIELDS TODD
IPC: C07D405/14
Filed: 2020-06-19
Abstract: En una modalidad, la presente invención proporciona un compuesto de la fórmula: o una sal farmacéuticamente aceptable del mismo, y métodos para usar este compuesto en el tratamiento de la diabetes mellitus tipo II.
Patent CR-20220125-A (CR)
Title: Cross-species anti-latent tgf-beta 1 antibodies and methods of use
Inventor: KOO XING'ER CHRISTINE
IPC: C12N15/13
Filed: 2020-08-28
Abstract: The objective of the invention is to provide cross-species anti-latent TGF-beta 1 antibodies which inhibit a protease mediated activation of latent TGF-beta 1 without inhibiting integrin mediated activation of latent TGF-beta 1. To obtain the anti-latent TGF-beta 1 antibodies of the invention, anti-latent-latent TGF-beta 1 antibodies which inhibit a protease mediated activation of latent TGF-beta 1 without inhibiting integrin mediated activation of latent TGF-beta 1 were screened, and then humanized, and further optimized. The invention also provides combination therapies comprising an anti-latent TGF-beta 1 antibody and one or more immune checkpoint inhibitors, preferably a PD-1 axis binding antagonists.
Patent EC-SP045380-A (EC)
Title: Tableta con alta carga de fármaco
IPC: A61K9/16
Filed: 2004-10-22
Abstract: La presente invención pertenece a una tableta con alta carga de fármaco, la cual comprende, como ingrediente activo, el Compuesto I de la fórmula (I), o una sal farmacéuticamente aceptable del mismo, en una cantidad de aproximadamente el 30 por ciento al 80 por ciento en peso de la fracción activa, basándose en el peso total de la tableta.
Patent EC-SP077130-A (EC)
Inventor: ROSENTRETER ULRICH
IPC: A61K31/4427
Filed: 2007-01-05
Abstract: The present invention relates to the use of substituted 2-thio-3,5-dicyano-4-phenyl-6-amino-pyridines of the formula (I) wherein the terms A and R2 are herein defined, for treatment of nausea and vomiting.
Patent EC-SP088455-A (EC)
Title: Nuevos derivados de indolizina, su proceso de preparación y las composiciones terapéuticas que los comprenden
Inventor: WAGNON JEAN
IPC: A61K31/454
Filed: 2008-05-16
Abstract: Derivados de indolizina de fórmula general (I) en la que, X representa un radical -(CH2)n- siendo n un número entero que va de 1 a 6, o un grupo de fórmula CH2-Z-(CH2)2-, en la que Z representa un grupo O(CH2)m- en la que m es un número entero que va de 0 a 3, R1 representa un radical alquilo C1-C8 lineal, ramificado o cíclico; Am representa un grupo NR3R4 en el que R3 y R4 son idénticos o diferentes y representan de manera independiente el uno del otro - un átomo de hidrógeno, - un radical alquilo C1-C6 lineal, ramificado o cíclico, o C1-C3 sustituido con un radical cicloalquilo C3-C6, - o un radical (CH2)l-O-B, en el que B representa un átomo de hidrógeno o un radical alquilo (CH2)k, siendo l y k números enteros l ³ 2 y l+k £ 6 o R3 y R4 forman junto al átomo de nitrógeno al que están unidos un heterociclo de 4 a 6 eslabones que puede contener opcionalmente uno o varios heteroátomos elegidos entre N y O y que contiene opcionalmente uno o varios sustituyentes elegidos entre un radical alquilo C1-C6 lineal, ramificado o cíclico, R2 representa un átomo de hidrógeno o un radical alquilo C1-C6 lineal, ramificado o cíclico, y sus sales aceptables desde un punto de vista farmacéutico.
Patent EC-SP088517-A (EC)
Title: Procedimiento para la preparacion del inhibidor del ciclo celular-779 cristalino y purificado
Inventor: TONG WEI
IPC: C07D498/12
Filed: 2008-06-09
Abstract: La presente invención proporciona CCI-779 cristalino purificado y procedimientos para preparar el mismo.
Patent EC-SP099735-A (EC)
Title: Polipeptidos de factor vii modificados y usos de los mismos
Inventor: MADISON EDWIN L
IPC: C07K14/745
Filed: 2009-11-13
Abstract: Se suministran polipéptidos de factor VII modificados y usos de los mismos. Dichos polipéptidos FVII modificados incluyen Factor VIIa y otras formas del Factor VII. Entre los polipéptidos FVII suministrados se encuentran aquellos que tienen actividades alteradas, típicamente actividad procoagulante alterada, incluyendo actividades procoagulante aumentadas. Así, dichos polipéptidos modificados son terapéuticos.
Patent EC-SP105163-A (EC)
Title: Composiciones farmaceuticas de agonista parcial de 5ht4
Inventor: AUBERT JEROME
IPC: A61K47/14
Filed: 2010-06-16
Abstract: Una composición farmacéutica sólida para administración oral, la cual comprende tegaserod en forma de base o de sal, en una cantidad de hasta el 10 por ciento en peso, un agente de volumen en una cantidad del 70 al 90 por ciento en peso, un desintegrante en una cantidad menor al 15 por ciento en peso, un abrillantador, y un lubricante.
Patent EC-SP951525-A (EC)
Title: Articulo absorbente
Inventor: RONNBERG PETER
IPC: A61F13/15
Filed: 1995-09-04
Abstract: El invento se refiere a un articulo absorbente, tal como un pañal, un protector de incontinencia o similar. Una membrana esencialmente impermeable al líquido esta tendida entre una capa de cubierta interior y una capa absorbente situada exteriormente respecto a ella con el objeto de impedir que la orina se mezcle con heces en el área posterior del artículo. El articulo tiene una abertura hacia una bolsa situada fuera de la membrana para hacer posible el transporte de orina desde el área frontal a mojar el articulo a un área posterior del cuerpo absorbente que se halla exteriormente respecto a la membrana.
Patent EC-SP972301-A (EC)
Title: Triciclicos sustituidos
Inventor: DILLAR ROBERT D
IPC: A61K31/403
Filed: 1997-10-30
Abstract: El invento se refiere a un compuesto de la fórmula III (gráfico), donde: A es fenilo o piridil donde el nitrógeno está en la posición 5-,6-,7- o 8; uno de B o D es nitrógeno y el otro es carbono; Z es ciclohexenil, fenil, piridil, donde el nitrógeno está en la posición 1-,2- o 3 o un anillo heterocíclico de 6 miembros conteniendo un heterroátomo seleccionado de entre el grupo que consiste en azufre u oxígeno en la posición 1,2 o 3 y nitrógeno en la posición 1-,2-,3-, o 4; es un enlace doble o simple. R20 es seleccionado de entre los grupos (a)(b) y (c) donde ; (a) es -(C5-C20) alquilo, -(C5-C20) alquenil, -(C5-C20) alquini, radicales carbocíclicas o radicales heterocíclicas o (b) es un miembro de (a) sustituído con uno o más sustituyentes que no interfieren independientemente seleccionado; o (c) es el grupo -(L)- R80; donde -(L)- es un grupo de unión divalente de 1 a 12 átomos seleccionados de entre carbono, hidrógeno, oxígeno, nitrógeno y azufre; donde la combinación de átomos en-(L) son seleccionados del grupo que consiste de (i) carbono e hidrógeno solamente, (ii) solamente un azufre, (iii) solamente un oxígeno, (iv) solamente uno o dos nitrógeno e hidrógenos (v) carbono, hidrógeno y azufre solamente y (vi) y cabono, hidrógeno y solamente oxígeno; y donde R80 es un grupo seleccionado de entre (a) o (b); R21 es un sustituyente de no interferencia R1 es -NHNH2 o -NH2; R2 es seleccionada del grupo -OH, -08CH2) tR5 donde R5 es CN o fenil, o (La) - (grupo ácidico), donde -(La)- es un enlasador que tiene un enlasador ácido de longitud de 1 a 7 y t es 1-5; R3 es seleccionado a partir de un sustituyente de no interferencia, radicales carbocíclicos, radicales carbocíclicos sustituidos con sustituyente que no interfieran, radicales heterocíclicos y radicales heterocíclicos sustituídos con sustituyentes que no interfieran; o una sal farmacéuticamente aceptable, racemato, solvato, tautómero somer óptico o derivados prodrogas de esto; provisto de que cuando R3 es H, R20 es bencilo y m es 1 o 2; R2 no puede ser -O(CH2)mH; y cuando D es nitrógeno, el heterroátomo de Z es seleccionado de entre el grupo que consiste de azufre u oxígeno en la posición 1-,2- o 3 y nitrógeno en la posición 1-, 2-, 3 o 4.
Patent FI-20000341-A (FI)
Inventor: LARES MATTI
IPC: D21G1/02
Filed: 2000-02-16
Abstract: A method and a device for calendering paper in a calender which comprises at least one calender unit (10; 110) in which a first calendering nip (N1; N3) is formed between a heatable calender roll (16; 116) and an extended-nip roll (12; 112), which nip is an extended nip, through which a paper web (W) is guided to run in order to calender the paper on at least one side. In the calender unit (10; 110), a second calendering nip (N2; N4) is formed with the heatable calender roll (16; 116) and a third calender roll (17; 117), which nip is a roll nip, and the paper web (W) is guided to run through said roll nip (N2; N4) such that, in both calendering nips (N1, N3; N2, N4), the same side of the paper web (W) is in contact with the heatable calender roll (16; 116).
Patent GB-1050086-A (GB)
IPC: F02K9/24
Abstract: 1,050,086. Rocket motors. SOCI•T• NATIONALE D'ETUDE ET DE CONSTRUCTION DE MOTEURS D'AVIATION. Feb. 10, 1964 [Feb. 13, 1963], No. 5425/64. Heading F3A. A rocket motor comprises a sleeve 1 with a thermal protection lining 2 itself lined with an inhibitor 3 so machined that it is thicker at the ends and middle of the sleeve. Flanges may be formed at the ends of the sleeve, so that it may be joined to similar sleeves by means of rings 5. Propellant charges 6, 6<SP>1</SP> are cast in the sleeve in such a way that an axial gap e exists between them and a e gap - is left at each end of the sleeve. Propel- 2 lant 6 may be introduced from one end around a core to form the axial passage 8, the sleeve then being inverted to introduce propellant 6<SP>1</SP> from the other end. The gap between the charges is maintained by placing in the sleeve a body which can be removed after casting by a solvent, or a body made of removable parts, or a rapidly combustible body which is burnt out on firing the rocket. More than two grains may be cast in the sleeve. The lining 2 may be omitted.
Patent GB-1052513-A (GB)
IPC: H01J61/52
Abstract: 1,052,513. Discharge tubes. EGERTON, GERMESHAUSEN & GRIER Inc. Feb. 24, 1964 [June 26, 1963], No. 7597/64. Heading H1D. An electric arc-discharge device comprises a body having a passage therethrough constituting the electrode chamber of the device, and being formed to constitute a vessel for circulating coolant around the passage; the vessel being such that when filled with coolant, the coolant therein surrounds the passage over substantially its entire length. The flash device shown comprises electrodes 7 and 11 e.g. of tungsten, of which at least one is preferably sintered, attached to copper tubing connectors 2 and 10 to which are bonded end caps 3 and 9 which are bonded by glass to metal seals or by solder seals to the surface of a chamber 5 having an inlet 4 and outlet 8 for a fluid coolant and on which is wound a wire trigger electrode 14. The discharge chamber 13 may be filled with xenon or argon. Alternative embodiments are described (Figs. 2-4, not shown) in which : (a) internal end caps are used; or (b) the discharge chamber is enclosed by but separate from the coolant chamber; or (c) the device is bent to a helical or other non-linear configuration. The flash device may be used as a source of light or for switching purposes, and may have an air filling or be evacuated. A dye may be added to the coolant to control the wavelength of the light output. A fluid may be pasteurized by passing it through the coolant chamber. The device may be used to subject a liquid or gaseous chemical substance to a flash of light to either effect a chemical reaction or to act as a catalyst in a chemical reaction.
Patent GB-1054911-A (GB)
IPC: H05B6/80
Abstract: 1,054,911. Microwave ovens. PYE Ltd. Dec. 11, 1963 [Jan. 5, 1963], No. 597/63. Heading H5H. A microwave oven, particularly for thawing food, is provided with additional heat to raise the air temperature within above the dew point by resistance heaters secured under the oven floor in a warming drawer.
Patent GB-1225295-A (GB)
IPC: H01H35/26
Filed: 1968-07-11
Abstract: 1,225,295. Vehicle suspension. GENERAL MOTORS Ltd. 3 July, 1969 [11 July, 1968], No. 33035/68. Heading B7D. [Also in Divisions F2 and H1] A pressure responsive relief valve and switch assembly for controlling an electrically driven compressor in a motor vehicle air suspension system, comprises a piston 50 movable against a spring loading 46 by fluid in the system, to open a relief port 14, and an over-centre spring 64 passing through an aperture 62 in the piston so as to be operable by movement of the piston when the air pressure reaches the required value, and prior to opening of the port 14, to open the contacts 74 of the switch and stop the compressor.
Patent GB-1227544-A (GB)
IPC: H01J29/07
Filed: 1968-08-26
Abstract: 1,227,544. Making shadow masks. BUCKBEE-MEARS CO. 26 Aug., 1968 [11 June, 1968], No. 40658/68. Heading B3A. [Also in Division H1] A self-supporting shadow mask for a colour television tube comprises a thin metallic sheet, e.g. of stainless steel, having a concave apertured portion 10 surrounded by an imperforate rim 11 which extends rearwardly at 12 and which is provided with a continuous strengthening rib 13, the portion 12 merging into a flange portion 14 extending inwardly. The flange portion 14 acts as a haze shield and may end in a lip 15, as shown, or may be flared outwardly to the envelope to form a beam shield portion. Three mounting members may be welded to the rim 12, each mounting member comprising a stainless steel strip from which a tongue is punched out, the end of the tongue being provided with a hole for engaging a mounting pin or stud projecting inwardly from the tube envelope. In manufacture, the area 10 is formed in the centre of a metal sheet by a photo-resist method and the metal sheet is annealed and rolled before insertion into a die block. If the mask is rectangular, as shown, notches are cut in the four corner areas, and the rim is drawn down preferably in a step-by-step manner. After the rim 12 has been formed, the flange 14 is formed by flaring the remainder of the sheet, preferably the long sides first then the short sides and finally pressing the corner areas inwards. The mask is clamped whilst the corners and gussets are spotwelded, and the mounting means are welded to the outside of the rim 12. Finally the strengthening rib 13 is formed in the rim 12 whilst the mask is held securely in a fixture.
Patent GB-1229593-A (GB)
IPC: C07F9/38
Filed: 1968-04-18
Abstract: 1,229,593. # - Haloethylphosphonic acids. GAP CORP. 18 April, 1968 [27 April, 1967], No. 18330/68. Heading C2C. A beta - haloethylphosphonic acid is prepared by (a) heating to a temperature of between 140‹ and 160‹ C. a tris(2 - haloethyl)phosphite in the presence of an organic solvent (e.g. cumene, xylene, o-dichlorobenzene) inert to the reaction to produce a bis(2 - haloethyl)betahaloethylphosphonate, (b) removing the solvent from the reaction mixture, (c) contacting the bis(2- haloethyl)betahaloethylphosphonate, without purification, with a strong mineral acid to produce a betahaloethylphosphonic acid, either by refluxing with an aqueous solution of the said acid, or by heating to a temperature of between 145‹ and 220‹ C. with an anhydrous hydrogen halide. The 2 - chloroethylphosphonic acid may be further reacted with phosphorous pentachloride to give 2 - chloroethylphosphonyl dichloride.
Patent GB-1230995-A (GB)
IPC: D01H4/50
Filed: 1967-09-18
Abstract: 1,230,995. Piecing up in open end spinning. T.M.M. (RESEARCH) Ltd. 30 Aug., 1968 [18 Sept., 1967], No. 42438/67. Addition to 1,192,357. Heading DID. On end breakage or upon starting open end spinning in a chamber 15 the path of the spunyam between the delivery rollers 20, 21 and the remainder of the take up means 22-24 is extended so that on subsequent disengagement of the delivery rollers 20, 21 the end of yam can be returned into the chambers to contact and twist in fibres fed through channel 13 to the collecting surface 14. A longitudinal bar 28 with a yarn engaging pin 29 when longitudinally displaced causes the yam to follow an extended path shown in chain dot lines. The rollers 20, 21 continue to rotate while the bar is displaced, the other parts of the take up means, and the rollers 11, 12 having been halted. When the yarn follows the extended path, rollers 20, 21 are halted, rollers 11, 12 are rotated to feed fibres to the chamber, the remainder of the take up means resumes working, the rollers 20, 21 are separated to feed back the yarn into the chamber and are then subsequently re-engaged and rotated for normal yarn delivery.
Patent GB-1232048-A (GB)
IPC: A61G11/00
Filed: 1968-07-22
Abstract: 1,232,048. Treatment chambers. O. H. DRAGER [trading as DRAKERWERK, HEINR. & BERNH. DRAGER]. 22 July, 1968 [22 July, 1967], No. 34921/68. Heading A5R. [Also in Divisions F4 and G3] An incubator for a baby 3 comprises a housing 1, a device 7 for heating the atmosphere within the housing, temperature responsive devices 4, 5 for sensing the temperature of the said atmosphere and the baby's skin respectively, and a control device 6 connected to the said temperature responsive devices 4,5, the arrangement being such that if the temperature of the skin rises above or falls below a specific normal value the temperature of the atmosphere is decreased or increased respectively between certain limits. In one embodiment the temperature of the said atmosphere cannot be decreased or increased below and above lower and upper critical values. In another embodiment the arrangement is such that, for an increase or decrease in the skin temperature from said specific normal value, the temperature of the atmosphere is decreased or increased respectively, in proportion to said increase or decrease in the skin temperature.
Patent GB-1232086-A (GB)
IPC: B65D5/60
Filed: 1968-06-21
Abstract: 1,232,086. Lined cartons. HAVOPAK Ltd. 21 June, 1968, No. 29604/68. Heading B8P. The collapsible container erected from the blank shown comprises an outer carton 1 which may be of cardboard and a non-pervious inner bag 2 which may be of plastics, e.g. polypropylene. The central portion (6), Fig. 1 (not shown), of the bag 2 has a width slightly greater than twice that of each of the carton wall panels 2 to which it is adhered. The open upper end portion (8) of the bag 2 is attached to carton end flaps 4 by triangular areas 13 of adhesive. The closed lower end portion 7 of the bag 2 is not attached to the carton and is shaped to have an extremity 17 which may be folded over to one side when the end flaps 5 of the erected container are closed. The bag 2 may be cut from a length of flattened tubing formed from a doubled-over strip of material or two superimposed strips sealed together at their edges and the upper end portions (8) may be in the form of a truncated triangle, two triangles, or a rectangle, Figs. 1, 6, 8 (not shown). Adhesive areas 10 on the wall panels 3 may be applied in strips around the edge of a panel or over the whole panel, Figs. 7, 9 (not shown), and in each case a corner strip 12 is left free of adhesive. The bag 2 is adhered to the carton blank 1 such that corners 15 may be turned in after filling of the erected container to prevent escape of the contents. The free edges of the end panels 3 may be connected by a strip of sealing tape (16), Fig. 3 (not shown).
Patent GB-1232564-A (GB)
IPC: C07F9/6509
Filed: 1969-01-30
Abstract: 1,232,564. Phosphoric acid esters. FARBENFABRIKEN BAYER A.G. 30 Jan., 1969 [2 Feb., 1968], No. 5213/69. Heading C2C. [Also in Division A5] Phosphoric, phosphonic or thiono-phosphoric (-phosphonic) acid esters of the general formula in which R 1  and R 3  are each a straight or branched (possibly halogen substituted) alkoxy radical with 1 to 6 carbon atoms or C 1 -C 4  alkylamino or di-C 1 -C 4  alkylamino group, R 2  and R 4  are each a C 1 -C 4  alkyl, C 1 -C 4  haloalkyl, alkylamino, dialkylamino, alkoxy, haloalkoxy or phenyl radical, and X and Y are oxygen and/or sulphur atoms are prepared by reacting a phosphoric or thionophosphoric (-phosphonic) acid ester halide of the formula in which Hal is a halogen atom with maleic acid hydrazide in the presence of an acid-binding agent. The esters possess insecticidal and acaricidal properties.
Patent GB-1239427-A (GB)
IPC: F15B13/01
Filed: 1968-06-28
Abstract: 1,239,427. Driving winches. ISHIKAWAJIMA-HAKIMA JUKOGYO K.K. 28 June, 1968 [3 July, 1967], No. 30911/68. Heading B8B. [Also in Division F2] A valve for controlling the return flow from a winch driving hydraulic motor when the winch is lowering a load has a first valve member 10 movable downwards against the spring 22 under the action of fluid pressure in chamber 11 which is connected via conduit 7 and the motor control valve (1) to a pressure source. The downward movement connects the inlet and outlet passages 9, 6 comprising the return flow path. The inlet pressure is communicated by passage 12, chamber 35 and passage 13 to a chamber 14 to move an auxiliary valve 16 upwards against spring 18 so as to block a first discharged passage 21 from the chamber 23 with a check valve 20 when the bottom of valve member 10 moves to a positisn just above the valve 16. The downward movement of the valve member 10 is thus checked and can only continue slowly by discharge of fluid from chamber 23 via restricted passage d. Cavitation in the pump return flow is thus prevented. In a modification an auxiliary valve is movable in a separate chamber under the influence of fluid pressure in chamber 11 to which it is connected to control the discharge from chamber 23, the restricted path being provided by an aperture in a spring-loaded check-valve. The motor control valve (1) is movable to three positions for respectively lifting, lowering and stop by the motor and in the lowering position acts to connect the pressure source to the chamber 11 and to connect the motor return through the valve (V) comprising the valve member 10.