Patent SG-11201407981R-A (SG)
Title: Compositions comprising an anti-pdgf aptamer and a vegf antagonist
Inventor: CHANG BYEONG SEON
IPC: A61K38/00
Filed: 2013-05-31
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 5 December 2013 (05.12.2013) WIPOIPCT (10) International Publication Number WO 2013/181495 A2 (51) International Patent Classification: A61K39/395 (2006.01) A61K31/711 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/043536 31 May 2013 (31.05.2013) English English (30) Priority Data: 61/654,672 61/778,208 1 June 2012 (01.06.2012) US 12 March 2013 (12.03.2013) US (71) Applicants: OPHTHOTECH CORPORATION [US/US]; 5 Vaughn Drive, Suite 106, Princeton, New Jer­ sey 08540 (US). EVERETT, Zoe (executor for the de­ ceased inventor) [US/US]; 25 Timber Lane, Randolph, New Jersey 07856 (US). GELTMAN, Marcia (executor for the deceased inventor) [US/US]; 20 Valley Road, Suite 300, Mount Arlington, New Jersey 07856 (US). GIELOW, Richard (executor for the deceased inventor) [US/US]; 2277 Oyster Bay Lane, #2104E, Gulf Shores, Alabama 36542 (US). (72) Inventor: EVERETT, Richard (deceased). (72) Inventor: CHANG, Byeong Seon; 14735 Sutton Street, Sherman Oaks, California 91403 (US). (74) Agents: LANGER, Matthew E. et al.; Cooley LLP, 1299 Pennsylvania Ave, Suite 700, Washington, District of Columbia 20004 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17 : — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) Published: — without international search report and to be republished upon receipt of that report (Rule 48.2(g)) — with sequence listing part of description (Rule 5.2(a)) (54) Title: COMPOSITIONS COMPRISING AN ANTI-PDGF APTAMER AND A VEGF ANTAGONIST FIG 77 < 1 o\ T-H 00 T-H rn i-H (57) Abstract: The present invention directed is to compositions comprising an anti-PDGF aptamer and a VEGF antagonist. In cer- O tain embodiments, the compositions of the invention are useful for treating or preventing an ophthalmological disease. N 10-2.5 10 0 0 Cone fnM)