baber/WOPTO huggingface dataset:
Patent AU-2021202579-B2 (AU)
Title: Methods and compositions for cns delivery of iduronate-2-sulfatase
Inventor: ZHU GAOZHONG
IPC: A61K38/46
Filed: 2021-04-27
Granted: 2023-06-29
Abstract: The present invention provides, among other things, compositions and methods for CNS 
delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some 
embodiments, the present invention includes a stable formulation for direct CNS intrathecal 
administration comprising an iduronate-2-sulfatase (12S) protein, salt, and a polysorbate 
surfactant for the treatment of Hunters Syndrome.
Patent AU-2022256158-B2 (AU)
Title: PTH prodrugs
Inventor: SPROGØE KENNETT
IPC: C07K14/575
Filed: 2022-10-20
Granted: 2023-09-28
Abstract: The present invention relates to a PTH prodrug or a pharmaceutically acceptable salt thereof comprising a 
conjugate D-L, wherein D is a PTH moiety; -L comprises a reversible prodrug linker moiety -L-, which moiety 
-L 1- is connected to the PTH moiety -D through a functional group of PTH; wherein -L 1- is substituted with 
L2 -Z' and is optionally further substituted; wherein -L 2 -is a single chemical bond or a spacer moiety; and -Z' 
is a water-insoluble carrier moiety. The PTH prodrug may be used to treat, control, delay or prevent 
diseases which can be treated with PTH including hypoparathyroidism (HP). The PTH prodrug may be 
administered via subcutaneous injection.
Patent AU-2023201028-B2 (AU)
Title: Hybrid time-of-flight and imager module
Inventor: ONAL CANER
IPC: G01S17/89
Filed: 2023-02-22
Granted: 2023-11-16
Abstract: The present disclosure relates to systems and methods that provide both an image of a 
scene and depth information for the scene. An example system includes at least one time-of
flight (ToF) sensor and an imaging sensor. The ToF sensor and the imaging sensor are 
configured to receive light from a scene. The system also includes at least one light source and 
a controller that carries out operations. The operations include causing the at least one light 
source to illuminate at least a portion of the scene with illumination light according to an 
illumination schedule. The operations also include causing the at least one ToF sensor to 
provide information indicative of a depth map of the scene based on the illumination light. The 
operations additionally include causing the imaging sensor to provide information indicative 
of an image of the scene based on the illumination light.
Patent JP-3863338-B2 (JP)
IPC: B24C1/10
Filed: 2000-03-22
Granted: 2006-12-27
Abstract: Device includes at least one 0.1-5 g projectile (11) able to be projected in the direction of the surface (S) to be treated by a vibrating surface (7) under the effect of vibrations from a sonotrode (3). Retainer (9) provided for holding each projectile (11) in the device when the latter move away from the surface (S) to be treated. The retainer (9) holds the projectiles in the device independently of the surface (S) to be treated, and guides the movement of each projectile before and after rebound on the vibrating surface (7).  An adjuster is provided for initiating the movement of each projectile (11) on coming into contact with the vibrating surface (7) whatever the orientation of the device.
Patent JP-3860406-B2 (JP)
IPC: G01C19/5607
Filed: 2000-10-16
Granted: 2006-12-20
Abstract: PROBLEM TO BE SOLVED: To provide a tuning fork-shaped angular velocity sensor with increased productivity by fixing an oscillation frequency of vertical oscillation for maintaining a detuning frequency within a specification value and improving sensitivity and detection precision. SOLUTION: In this tuning fork-shaped angular velocity sensor, a pair of tuning fork arms are formed of tuning fork-shaped quartz pieces extended from a tuning fork base part, and vertical oscillations generated in the tuning fork arms by Coriolis force in the opposite directions mutually are detected as against horizontal tuning fork oscillations by the tuning fork arms in the opposite directions mutually. In this sensor, a gap fixing the oscillation frequency of the vertical oscillation is arranged in the thickness direction of the tuning fork-shaped quartz piece. The gap is arranged in the base part of the tuning fork-shaped quartz piece.
Patent JP-4432257-B2 (JP)
IPC: G10L19/00
Filed: 2000-12-12
Granted: 2010-03-17
Abstract: PROBLEM TO BE SOLVED: To solve the problem that voice information cannot be compressed or stretched in a channel of a low speed transmission rate. SOLUTION: At transmission, compressed voice data is thinned by a thinning function 124, and at reception, the data is interpolated by an interpolating function 154. The data interpolation interpolates a copy, a connection, a mean value or the like utilizing data immediately before or immediately after or the like. In the case of mixing a low speed and a high speed of the transmission rate in multiple addresses, it includes switching of whether the thinning/interpolating is executed or not by its decision.
Patent JP-4198882-B2 (JP)
IPC: C12N15/09
Filed: 1998-10-06
Granted: 2008-12-17
Abstract: The present invention relates to the use of CD81 protein and polynucleic acid in the therapy and diagnosis of hepatitis C and pharmaceutical compositions, animal models and diagnostic kits for such purposes.
Patent JP-4302883-B2 (JP)
IPC: C14C3/02
Filed: 1998-10-28
Granted: 2009-07-29
Abstract: Leather is tanned by cross-linking collagen with tris(hydroxymethyl)phosphine or a condensate of a tetrakis(hydroxymethyl)phosphonium salt with an amide or amine in a main tannage or retannage.
Patent JP-4410412-B2 (JP)
IPC: C12N15/09
Filed: 1998-11-10
Granted: 2010-02-03
Abstract: A polypeptide, called Tir (for <u>t</u>ranslocated <u>i</u>ntimin <u>r</u>eceptor), which is secreted by attaching and effacing pathogens, such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli. These bacterial pathogens insert their own receptors into mammalian cell surfaces, to which the bacterial pathogen then adheres to trigger additional host signaling events and actin nucleation. Diagnosis of disease caused by pathogenic E. coli can be performed by the use of antibodies which bind to Tir to detect the protein or the use of nucleic acid probes for detection of nucleic acids encoding Tir polypeptide. Isolated nucleic acid sequences encoding Tir polypeptide, Tir peptides, a recombinant method for producing recombinant Tir, antibodies which bind to Tir, and a kit for the detection of Tir-producing E. coli are provided. A method of immunizing a host with Tir to induce a protective immune response to Tir or a second polypeptide of interest is also provided. A method for screening for compounds which interfere with the binding of bacterial pathogens to their receptors is further provided.
Patent JP-4054176-B2 (JP)
IPC: C07C51/573
Filed: 1999-02-23
Granted: 2008-02-27
Abstract: Phthalic acid anhydride is recovered from a gas stream containing phthalic acid anhydride vapors by passing the gas stream upwardly through a vertical tube so that the gases expand at the orifice at the upper end of the tube and mix with granules entrained above the tube by fluidizing gas of a fluidized bed of phthalic acid anhydride granules around the tube. The tube, kept free from phthalic acid anhydride granules and the fluidized bed, is indirectly cooled.
Patent JP-4365529-B2 (JP)
IPC: B29C48/67
Filed: 1999-05-07
Granted: 2009-11-18
Abstract: A polymer is fed upstream into an extruder. The polymer is melted and mixed in a zone (A). Cellulosic fibres are fed into the extruder in a zone (B). A mixture of the polymer and the fibres obtained in zone (B) is transported through a degassing zone (C) and then through a pressure building zone (D). The mixture is released from zone (D) into a die. Each of zones (A), (C) and (D) includes at least one positive transportation screw element. The zone (B) includes at least one positive transportation screw element, at least one kneading section and at least one negative transportation screw element such that the cellulosic fibres are fibrillated to obtain cellulosic fibres with an aspect ratio as high as possible while simultaneously mixing the cellulosic fibres with the melted polymer.
Patent JP-4105391-B2 (JP)
IPC: B60K15/04
Filed: 1998-12-14
Granted: 2008-06-25
Abstract: An apparatus for monitoring the closed position of a locking gas cap (10) with a magnet (32) disposed at or in the locking gas cap and a solenoid (42) disposed at the tank connection pipe (12), the locking gas cap (10) having a torque limiter (36), and the magnet (32) being coupled with the torque limiter in such a manner, that it reaches a position, in which the solenoid (42) is triggered, only when the limiting torque is reached.
Patent JP-4563583-B2 (JP)
IPC: F23D14/22
Filed: 1999-02-22
Granted: 2010-10-13
Abstract: Charge materials containing metal and/or metal oxides are fed into the metallurgical vessel in solid and possible molten form. The energy for melting and final reduction of the charge materials are provided electrically or by combustion/ gasification of materials containing carbon. <??>An Independent claim is given for a multifunction lance used for implementation of the method for producing a metal melt. The lance consists of several concentric tubes surrounding one another. The second tube is shaped as a Laval nozzle for delivery of oxygen, and surrounds a central tube serving for delivery of solid substances or dust. The fifth tube surrounding the fourth tube forms an annular gap whose discharge channels are directed away from the central longitudinal lance axis.
Patent JP-4199932-B2 (JP)
IPC: A23F5/08
Filed: 1999-11-04
Granted: 2008-12-24
Abstract: A coffee grinding, portioning, and pressing device (10) includes a coffee bean storage container (20) and coffee grinding mills (24) located under the storage container. Coffee ground by the mills is delivered from the grinding mills (24) into a ground coffee collection chamber (40) and then passes from the collection chamber through a motor-driven pressing tool (50) directly into a detachable delivery filter (14) which is temporarily attached to the device. The shape and rotational motion of the pressing tool cause the ground coffee to be directed through the tool and into the filter container. The pressing tool (50), which is biased downwardly by a spring tensioning mechanism (70) that transmits force to the pressing tool (50) through a tensioning drive axle (74), incrementally and uniformly tamps the coffee into the filter container as the tool rotates. The accumulation of compressed coffee underneath the pressing tool (50) applies upward pressure against the spring tensioning mechanism (70) and causes the pressing tool to rise upwardly as the tool rotates. When the pressing tool (50) has moved upward a predetermined distance, a shut-off switch of a portioning control mechanism (80) is activated, ceasing the further addition of ground coffee. A volume portioning adjustment mechanism (84) modifies the amount of ground coffee that is compacted into the delivery filter.
Patent JP-4567202-B2 (JP)
IPC: B23B31/14
Filed: 2000-01-10
Granted: 2010-10-20
Abstract: A collet for carrying a high-speed drill which comprises a collar (2) arranged to enclose a drill shank (1), an outer rim support (8) arranged for attachment to a drill, and a clamping mechanism between the collar and the outer rim support (8). The clamping mechanism is arranged to provide clamping forces between said outer rim support (8) and said collar so that said collar tightly grips a drill shank (1), as a consequence of centrifugal forces and of off center sprag effect forces.
Patent JP-3683814-B2 (JP)
IPC: G06F12/00
Filed: 2000-03-21
Granted: 2005-08-17
Abstract: The invention provides a method for removing code (applications and data) from read-only memory, and compacting the remaining code in memory either as an application is deleted or when there is not sufficient room to hold a new application. One or more "spare" memory segments are reserved for use during compaction. Where the code for removal shares a memory segment with other code that is not to be removed, the other code is copied to a spare memory segment, and then swapped back to its original location. The code can then be compacted to remove the "holes" left by the erased code.
Patent JP-4713036-B2 (JP)
IPC: C10J3/02
Filed: 2000-06-27
Granted: 2011-06-29
Abstract: An apparatus for pyrolysis and gasification of organic substances and mixtures thereof is provided with a pyrolysis reactor ( 1 ), a fluidized-bed firing ( 3 ) for pyrolysis residue, a reaction zone ( 2 ) for the pyrolysis gases ( 13 ) and circulating fluidized-bed material ( 35 ). The pyrolysis reactor ( 1 ) has a sluice for introducing application material ( 10 ) thereinto. An inlet for the fluidized-bed material ( 35 ) is disposed next to the combustion fluidized bed ( 3 ). Transport apparatus ( 14 ) for mixture of solid pyrolysis residue and circulating fluidized bed material ( 35 ) is disposed at or near a bottom of the fluidized bed ( 3 ) and lower end of the pyrolysis reactor ( 1 ). An overflow is situated at or near the top of the fluidized bed ( 3 ) while a heat transfer member is positioned within the reaction zone ( 2 ).
Patent JP-5276759-B2 (JP)
IPC: A01G31/02
Filed: 2000-11-07
Granted: 2013-08-28
Abstract: A method for producing molecules from plants, characterized in that the plants are cultivated in soil-less conditions and are supplied with a nutrient solution and/or sprayed with a leaching liquid, the solution and/or the liquid being subsequently recovered and treated to extract therefrom certain specific molecules which it contains and which have been released by the roots and/or top growth of the plants.
Patent JP-4447195-B2 (JP)
IPC: H04N5/91
Filed: 2000-10-30
Granted: 2010-04-07
Abstract: A method for editing source video in a DVD media for a slow motion recording special effect. According to the method, the DVD device receives a source video signal comprised of a plurality of source pictures. Each of the source video pictures is recorded in a selected picture frame on the DVD media. Subsequently s−1 copies of the selected source video picture on the DVD media in s−1 frames adjacent to the selected picture frame. For the purposes of the invention as described herein, s can be an integer value determined by a user selected motion speed. The user selected motion speed will be 1/s times slower relative to a normal motion speed. In an alternative embodiment, the method can be used for editing source video in a DVD media for a fast motion record special effect. In that case, the DVD device receives a source video signal comprised of a plurality of source pictures. Only one out of every n of the source video pictures is chosen as a selected source video picture. Each the selected source video pictures is recorded in a selected picture frame on the DVD media. Source video pictures that are not selected source video pictures are dropped. According to the invention, n can be an integer value determined by a user selected motion speed.
Patent JP-5008241-B2 (JP)
IPC: A23L25/10
Filed: 2001-03-12
Granted: 2012-08-22
Abstract: An improved coating apparatus and an improved method of coating a mass of centers are disclosed. The improved coating apparatus comprises a temperature sensor for measuring the temperature of the surface of the coated centers and/or a moisture sensor for measuring the moisture content of the surface of the coated centers. The improved method comprises drying coated centers by measuring the temperature of the surface of the coated centers in the mass using the temperature sensor and adjusting the temperature of the drying gas to maintain the surface temperature of the coated centers at a predetermined temperature and drying the coated centers until the moisture content of the surface of the coated centers is about 0 to about 30 percent water, by weight. Advantageously, the surface temperature and/or surface moisture measurements are conducted during the coating processing of the centers, while the centers are in the coating apparatus.
Patent JP-4841790-B2 (JP)
IPC: G06F21/60
Filed: 2001-03-19
Granted: 2011-12-21
Abstract: A cryptographic method of protection against fraud in transactions between an application and an electronic chip of a user. Both the electronic chip and the application compute a certificate (Sp, S) which is the result of applying a non-linear function f to a list of arguments (e<SUB>1, </SUB>e<SUB>2</SUB>) comprising at least a seed R and a secret key KO. A second secret key K' which is known only to the electronic chip and to the application is allocated to and kept secret in the electronic chip. Upon each authentication of the electronic chip, a mask M is determined by computing it from at least a portion of the secret key K'. The value of the certificate (Sp) is masked by means of the mask M to make available to the application only the masked value of the certificate (Spm). The application is used to verify the masked value of the certificate (Spm) computed by the electronic chip.
Patent JP-5535418-B2 (JP)
IPC: C08K5/549
Filed: 2001-03-26
Granted: 2014-07-02
Abstract: A method of using nanostructured chemicals as alloying agents for the reinforcement of polymer microstructures, including polymer coils, domains, chains, and segments, at the molecular level. Because of their tailorable compatibility with polymers, nanostructured chemicals can be readily and selectively incorporated into polymers by direct blending processes. The incorporation of a nanostructured chemical into a polymer favorably impacts a multitude of polymer physical properties. Properties most favorably improved are time dependent mechanical and thermal properties such as heat distortion, creep, compression set, shrinkage, modulus, hardness and abrasion resistance. In addition to mechanical properties, other physical properties are favorably improved, including lower thermal conductivity, fire resistance, and improved oxygen permeability.
Patent JP-4128008-B2 (JP)
IPC: G02B30/27
Filed: 2001-05-18
Granted: 2008-07-30
Abstract: The invention relates to a method for displaying three-dimensional images. In the method light beams (L<SUB>e</SUB>) are associated to several different screen points (P) of a screen ( 20 ). The light beams (L<SUB>e</SUB>) produce different views associated to different emission directions (E). The emission directions (E) are associated to the individual screen points (P). The light beams (L<SUB>e</SUB>) are generated by projecting light beams (L<SUB>d</SUB>), according to the angle of the adjacent emitting directions. According to the invention, light beams (L<SUB>e</SUB>) without viewing direction information are generated, essentially simultaneously, with pixels (C<SUB>d</SUB>) having different co-ordinates. These pixels (C<SUB>d</SUB>) are pixels of a two-dimension display ( 50 ), and they are associated to different emitting directions (E) of the appropriate screen points (P). The light beams (L<SUB>e</SUB>) produced by the pixels (C<SUB>d</SUB>) of the display ( 50 ) with different co-ordinates are imaged simultaneously in different deflection directions (D), as a function of the co-ordinates of the pixels (C<SUB>d</SUB>) producing the light beams (L<SUB>e</SUB>). The subject of the invention is an apparatus implementing the above method.
Patent JP-5468717-B2 (JP)
IPC: C04B38/00
Filed: 2001-05-10
Granted: 2014-04-09
Abstract: A ceramic comprising predominately a cordierite-type phase approximating the stoichiometry Mg<SUB>2</SUB>Al<SUB>4</SUB>Si<SUB>5</SUB>O<SUB>18 </SUB>and having a coefficient of thermal expansion (25-800° C.) of greater than 4x10<SUP>-7</SUP>/° C. and less than 13x10<SUP>-7</SUP>/° C. and a permeability and a pore size distribution which satisfy the relation 2.108 (permeability)+18.511 (total pore volume)+0.1863 (percentage of total pore volume comprised of pores between 4 and 40 micrometers)>24.6. The ceramic is suitable in the fabrication of cellular, wall-flow, diesel particulate filters having a pressure drop in kPa that at an artificial carbon soot loading of 5 grams/liter and a flow rate of 26 scfm is less than 8.9-0.035 (number of cells per square inch)+300 (cell wall thickness in inches), a bulk filter density of at least 0.60 g/cm<SUP>3 </SUP>and a volumetric heat capacity of at least 0.67 J cm<SUP>-3 </SUP>K<SUP>-1 </SUP>as measured at 500° C.
Patent JP-4142327-B2 (JP)
IPC: G02C9/00
Filed: 2002-04-10
Granted: 2008-09-03
Abstract: Magnification viewer includes a conventional glasses and a pair of magnifying lens units. The magnifying lens units are fixed to respective eyeglasses of the conventional glasses so that a wearer of the glasses can observe a magnified image of an object through the magnifying lens units. The magnifying lens unit includes an ocular and an objective lens that constitute a Galilean telescope. A prism is disposed between the ocular and the objective lens for deflecting the optical axis of the magnifying lens unit towards an object placed below the head of a wearer.
Patent JP-3847654-B2 (JP)
IPC: H04B1/707
Filed: 2002-04-10
Granted: 2006-11-22
Abstract: In a compressed mode, a spread spectrum communication device interleaves bit units across multiple frames using an interleaver, reduces the spreading factor using a framing/spreading unit, outputs the compressed mode frames at a predetermined compressed mode frame timing, and increases the average transmission power in the compressed mode at a radio frequency transmitter. Furthermore, a handover between different frequencies is carried out by establishing synchronization to another frequency carrier, based on a first search code and a second search code which have been detected, and moreover, a handover between different communication systems is carried out by establishing synchronization to a GSM, based on an FCCH and a SCH which have been detected.
Patent JP-3464666-B2 (JP)
IPC: B21D17/04
Filed: 2002-04-12
Granted: 2003-11-10
Abstract: <P>PROBLEM TO BE SOLVED: To provide a method for indenting a pipe material in which a penetrating quantity is small at the corner parts of the recessed part after processing, and a driving control of a workpiece is easy.  <P>SOLUTION: The metal pipe material 11 is fixed between an upper die 12 and a lower die 13. A plurality of rollers 14, 15, 16, 17, 18 of the same shape and material are attached in turn to the same processing part of the pipe material 11 and press deform this corresponding to prescribed parts of the upper die 12 and the lower die 13. The pipe is press deformed by respective rollers each differing in the distance from the pipe shaft center. At this time, the press deformed quantity becomes gradually larger, and finally the recessed part of a desired shaped and depth is formed. The shear droop at the corner parts of this recessed part becomes minimum, since the deformed quantity at respective rollers is made small and the desired processing is executed by a plurality of processing. A good product processed with high precision is obtained. The durability of a processing tool is increased, and a running a cost is improved.  <P>COPYRIGHT: (C)2004,JPO
Patent JP-4287114-B2 (JP)
IPC: A61B19/00
Filed: 2002-09-12
Granted: 2009-07-01
Abstract: A retaining device for axially restraining a sheath connected to a housing and a dilator connected to a hub includes a generally C-shaped clip having spaced apart circumferential ends defining a clearance opening that opens into the clip interior to permit the clip to be mounted on the hub and an enlarged part of the housing. The interior of the clip has first and second inwardly directed ridges located at opposite axial portions of the curved inner circumferential surface for overlapping portions of oppositely facing end surfaces of the hub and the enlarged part of the housing. The clip also includes one or more laterally outwardly extending finger engaging tabs to facilitate removal of the clip, and one or more circumferentially extending through slot communicating the inner surface of the clip with an outer surface of the clip to permit flexing of the clip during removal of the clip. <IMAGE>