baber/WOPTO huggingface dataset:
Patent PT-89367-A (PT)
Inventor: TEKAMP-OLSON PATRICIA
IPC: C12N1/15
Filed: 1988-12-30
Abstract: Yeast cell comprising a DNA construct that provides for the expression and secretion of a non-yeast protein is claimed, the DNA construct comprising a coding sequence under the control of yeast-recognised transcription initiation and termination sequences, the coding sequence encoding a precursor polypeptide comprising leader sequence and the non-yeast protein linked by a processing site that provides for the cleavage of the non-yeast protein from the precursor polypeptide, where the leader sequence is 25-50 N-terminal residues of the precursor polypeptide and comprises the signal peptide of a yeast a-factor precursor and a single glycosylation site. The non-yeast protein may be a mammalian protein eg insulin-like growth factor I or a precursor of human insulin eg human proinsulin or insulin a- and insulin b-chains linked by a yeast-recognised processing site cleaved in vivo, eg a processing site cleaved by the KEX2 gene prod of Saccharomyces. Also claimed is a double-stranded DNA molecule comprising a region encoding a precursor polypeptide secretable by a yeast host, the region, with reference to one of the strands, having the structure (I) 5'-AF-CH0-Xn-S-Gene-3' (I) (AF encodes a yeast a-factor signal; CH0 encodes a glycosylation site; Xn encodes a polypeptide of n amino acids in length that does not contain a glycosylation site or a processing site that provides for cleavage of the precursor polypeptide in vivo by yeast; n is 0-30; Gene encodes a non-yeast protein; S encodes a processing site that provides for cleavage of the precursor polypeptide, eg a dipeptide eg 5'-Lys-Arg-3' or 5'-Arg-Arg-3' recognised by the KEX2 endopeptidase).
Patent PT-93485-A (PT)
Inventor: JAMES CLAUDE
IPC: A61P29/00
Filed: 1990-03-16
Abstract: New derivatives of formula (I) in which R1=H, halogen, alkyl, alkyloxy, CF3, NH2, alkylamino, dialkylamino, OH, CH, phenyl or phenoxy, Ar=phenyl, naphthyl, pyridyl, quinolyl, isoquinolyl, thienyl, thieno[2,3-b]thienyl or thieno[3,2-b]thienyl (these groups optionally substituted with halogen, alkyl, alkyloxy, CF3, NH2, alkylamino, dialkylamino, OH or CN), p=0, 1 or 2, and A-either Z=valency bond and R2=H B-or Z=valency bond and R2=pyridyl, quinuclidinyl, 3-pyrrolidinyl, 3- or 4-piperidyl (these groups optionally being substituted with alkyl, hydroxyalkyl, phenyl or phenylalkyl) C-or Z=alkylene radical (1 to 4C) and R2=2-, 3- or 4-pyridyl, 3-quinuclidinyl, 2- or 3-pyrrolidinyl, 2-, 3- or 4-piperidyl (optionally substituted with alkyl, hydroxyalkyl, phenyl or phenylalkyl) or R2=CON(R3)(R4) where a) either R3 and R4 form a piperazine optionally substituted with alkyl, hydroxyalkyl, pyridyl, phenyl or phenylalkyl, b) or R3=H, alkyl, phenyl or phenylalkyl, or (CH2)nN(R5) (R6) where 1<n<4 and R5 and R6=H, alkyl, phenyl, phenylalkyl, or R5 and R6 form a morpholine, thiomorpholine, pyrrolidine, piperidine or piperazine ring, (optionally substituted with alkyl, hydroxyalkyl, pyridyl, phenyl, phenylalkyl or phenylcarbonyl), and R4=(CH2)nN(R5)(R6) defined as above, D- or Z=alkylene (1 to 4C) and R2=N(R3) (R4) or N(R5)R6) where R3, R4, R5 and R6 are defined as above in C b), on the understanding that the alkyls contain 1 to 4C in a straight or branched chain and that the invention relates to the racemates, the enantiomers and mixtures thereof, the diastereoisomers, pure or mixed, and the E and Z isomers, as well as to the salts of these products.   <IMAGE> (I)
Patent PT-96076-A (PT)
Inventor: BOUTANG JEROME JEAN-M
IPC: A23L19/00
Filed: 1990-12-04
Abstract: Fruit material is air-dried at material temperatures not exceeding 50 DEG C and preferably not exceeding 40 DEG C until 20 to 60% of its initial weight is evaporated and thereafter exposed to an aqueous medium containing one or more sugars and then preferably frozen. Fruit material, in particular frozen, having 40 to 80% of its original weight and containing some added sugar, preferably mono saccharide.
Patent PT-99855-A (PT)
Inventor: GMBH BODENSEEWERK GERATETECHNI
IPC: G01J1/00
Filed: 1991-12-18
Abstract: A procedure and an apparatus for the examination, in particular quality inspection, of optical components, in which an image is produced of the respective components to be examined, and defects on the imaged object are detected by image analysis, as well as the integration of this examination procedure into the production of the component. The optical components can be ophthalmic components such as spectacle lenses, contact lenses, intraocular lenses and the like.   <IMAGE>
Patent SI-9420020-A (SI)
Title: Light weight tool
Inventor: WURST WOLFGANG
IPC: H01R43/048
Filed: 1994-03-24
Abstract: A tool (10) for the termination of insulated wires in electrical connectors having different heights, which tool has means affording adjustment of the spacing between a pressing body (50), accommodated by a splice head, and a retaining body for the connector. The adjustment in height between the bodies is afforded by step adjustment and by an intermediate member (56, 58) affording smaller pitches, and the tool has attachment means for releasably attaching the tool to the retaining body.
Patent SI-9600215-A (SI)
Title: Terminal block for telecommunication assemblies
Inventor: MURKO VLADIMIR
IPC: H04Q1/16
Filed: 1996-07-04
Abstract: The aim of the invention is to improve the terminal block for telecommunication assemblies. Within the available space, based on the use of existing telephone exchanges, such a terminal block should provide the possibility of installing other, large volume electric components e.g. gas diverter which would provide the possibility of its general use be it in the sense of rugged or fine surge protection or other kinds of measures which are used with such terminal blocks, particularly in the sense of installing measuring plugs, computer protection filters and similar. The terminal block according to this invention is having its every terminal (2) made uniform in such a way that on each side it includes two pairs of shunting adapters (221', 221'' or 222', 222''). Besides, parts of both shunting adapters facing each other (221', 221'' or 222', 222'') are curved one against the other thus providing appropriate terminal springs (21', 21''). Further the complementary parts of the above mentioned terminal springs (21', 21'') are curved one against the other as gripping adapters (23', 23'')which are parallel and looking away from the shunting adapters (221', 221'' or 222', 222'').
Patent TR-22417-A (TR)
IPC: A23L27/20
Filed: 1985-04-11
Abstract: The sweetness of an ingestible product or oral composition containing a sweetening sugar or sugar alcohol in relatively large quantities can be reduced and/or the flavour enhanced by incorporation of at least one compound of the general formula (I)in which m represents 0 or 1, A represents a homocyclic or heterocyclic aromatic group with one or more rings; and B represents a hydrogen atom, a lower aliphatic group with 1-3 carbon atoms or a phenyl group; or, when m represents 0, A and B together represent a bivalent homocyclic or heterocyclic aromatic group with two or more rings, or a methylidene group carrying as a substituent a homocyclic or heterocyclic aromatic group with one or more rings; an aromatic ring of A, or of A and B together, optionally carrying one to three substituents selected from lower alkoxy groups, lower alkyl alkenyl groups, formyl or acetyl groups, hydroxy groups or acyloxy groups, and halogen atoms;C represents a hydrogen atom or an alkyl group or, when m represents 0, a hydroxy or alkoxy group;D represents an oxygen or sulphur atom;X<sup>+</sup> represents a hydrogen ion or another physiologically compatible cation;with the proviso that m represents 1 when S represents a substituted or unsubstituted phenyl group and Band C both represent hydrogen atoms; or when A represents an unsubstituted phenyl group, B represents an alkyl group and C represents a hydrogen atom.
Patent UA-13319-A (UA)
IPC: C07J1/00
Filed: 1986-04-03
Abstract: The invention refers to compounds having anti- inflammetory activity characterized by the formulaor a stereoisomeric component thereof, in which formula the 1,2-position is saturated or is a double bandX, is selected from hydrogen, fluorine, chlorine and bromineX<sub>2</sub> is selected from hydrogen, fluorine, chlorine and bromineR<sub>1</sub> is selected from hydrogen or a straight or branched hydrocarbon chain having 1-4 carbon atomsR<sub>2</sub> is selected from hydrogen or straight and branched hydrocarbon chains having 1-10 carbon atoms andR<sub>3</sub> is selected fromY is O or SR<sub>4</sub> is selected from hydrogen, straight or branched hydrocarbon chains having 1-10 carbon atoms or from phenylR<sub>5</sub> is selected from hydrogen or methyl andR<sub>6</sub> is selected from hydrogen, straight or branched, saturated or unsaturated hydrocarbon chains having 1-10 carbon atoms, an alkyl group substituted by at least one halogen atom, a heterocyclic ring system containing 3-10 atoms in the ring system, -(CH<sub>2</sub>)<sub>m</sub> CH(CH<sub>2</sub>)<sub>n</sub> (m=0,1,2; n=2,3,4,5,6), phenyl or benzyl groups which are unsubstituted or substituted by one or more alkyl, nitro, carboxy, alkoxy, halogen, cyano, carbalkoxy or trifluoromethyl group(s), provided that when R<sub>2</sub> is hydrogen R<sub>1</sub> is methyl.The invention also refers to a process and intermediates for the preparation of these compounds, a pharmaceutical preparation containing one of the compounds and a method for the treatment of inflammatory conditions.
Patent UA-13118-A (UA)
Title: Method for drying solutions and suspensions
Filed: 1989-11-03
Abstract: The invention relates to engineering of drying with sputtering and can be used for dewatering solutions and suspensions in chemical, food, pharmaceutical and other fields of industry. Method for drying solutions and suspensions includes sputtering those in counter direction to heat carrier that consists of central and peripheral flows. Peripheral flow of heat carrier is formed of vertical vortexes and central flow – of radial flows.
Patent UA-12855-A (UA)
Title: punch of press mold for die casting of aluminium components
Inventor: ABRAMOV VIKTOR VALERIANOVYCH
Filed: 1991-01-02
Abstract: A punch of press mold contains working and auxiliary surfaces. On it at a distance from end part of the working surface making 0.29-0.3 of external radiuses of punch is executed an annular bore with a width of 0.05-0.1 and depth of 0.15-0.2 from external radius of punch.
Patent BG-100007-A (BG)
Title: Method and system for 3-dimensional endocavitar echography
Inventor: DJAKOV KRISTIAN D
IPC: G01N29/06
Filed: 1995-09-18
Abstract: The method and the system are used in medical practice for the diagnostics of benignant and malignant diseases of the internal organs, for accurate planning of their surgical and conservative treatment and for monitoring their results. By the method full 3-dimensional pattern of a set to 2-dimensional data and a sequence of echographic images strictly orientated between themselves are produced in space out of which data for the investigated organs and structures are isolated. Then these are depicted in 3-dimensional type, the transducer being introduced into a human body cavity and the 2-dimensional patterns produced are positioned in parallel planes across an exactly determined interval being perpendicular to the axis of movement of the transducer in the zone under investigation. The transducer can make lateral scanning of the entire adjacent volume (360°) including all organs and structures around the cavity in which it had been introduced. The system includes and echograph supplied with a transducer for endocavitar echography, interface matching the input-output characteristics of the two devices, computer with an echograph patterns digitalization device, monitor for the output and the produced patterns and device for data conservation.
Patent BG-100200-A (BG)
Title: Extension device
Inventor: NESTOROV STANISLAV G
IPC: A61F5/04
Filed: 1995-12-07
Abstract: The device is used in human medicine, in particular in orthopoedics and traumatology for the treatment of fractures of tubular bones by means of permanent skeleton extension. The device (4) contains a basic (5) and a supplementary (6) staples interconnected in both their ends in such a way that they remain positioned at an angle one against the other. Both staples are fix-connected, and in one of the alternatives there is a facility for changing the angle between them. The basic staple (5) can be made as a springing structure, and the supplementary one (6) as two levers (14) of the first order connected by an arch across their points of support where one of the ends of the levers each are connected to the respective arm of the basic staple (5) and their other ends connected to an intermediary body (15) with a threading. Devices fitting transosteal wire (2) are fitted on both ends of the basic staple (5). In one of the alternatives each device is designed as a hollow body (17) fixed to the respective arm, containing a pivot (10) to which a curved part of the end of the staple (6) is fitted entering a longitudinal hole made at an angle in comparison with the axis of body (17). The curved part is fixed by a pressing nut (11) screwed on a thread from one of the ends of body (17). Facilities for the suspension of weights (7) are designed on both staples (5 & 6).
Patent BG-100867-A (BG)
Title: Method and device for cutting rod material
Inventor: NACHEV VALENTIN R
IPC: B23D53/08
Filed: 1996-09-25
Abstract: The method and the device are used in the mechanicalengineering enterprises for cutting of blanks having differentlengths and diameters. They increase productivity, reduce materialconsumption, pollution, noise and the technological waste andimproves the safety of labour. The method includes the setting ofthe material and bringing it to rotative motion, andsimultaneously the cutting tool is driven and feeds to theexternal surface of the material. Cutting is made by alternatingspeeds and feeding along a spiral, and it continues, at the most,to cutting half of the diameter of the material. The deviceincludes a housing (1) in the front part of which a supportingframe (3) of the cutting mechanism (9) is fitted. In the rear partof housing (1) a feed mechanism (4) is fitted, and between it andthe cutting mechanism (9) a revolving-clamping device (8) ismounted.6 claims, 8 figures
Patent BG-101622-A (BG)
Title: System for computer date storage
Inventor: MALCOLM PETER BRYAN
IPC: G06F17/30
Filed: 1997-06-16
Abstract: In the system of hierarchical control of storage the filesare automatically archivated when no access to them has been madefor a specified time period. In enormous data base files theycannot be archivated even if a small number of recordings in themhas been used. The system maintains an auxiliary data baseindicating to which data unit access has been made and on whatdates. The units to which no access was made can be archivated anderased from the disc file in order to reduce the need for memory.
Patent BG-104091-A (BG)
Title: Cd154 blockade therapty in tissue transplantation of pancreatic isles
Inventor: KENYON NORMA S
IPC: A61P37/06
Filed: 2000-01-18
Abstract: The invention relates to methods and medicamentous preparations for the inhibition of the rejection of insulinproducing tissue of transplant recepient, as well as to methods and preparations for extending the survival or the function of the graft, for reversibility of the rejection of the graft or the restoration of the function of an impaired graft and for inducing immune tolerence towards a transplant, insulinproducing, tissue. The above methods and preparation are suitable for the treatment or prevention of defects in the metabolitic control of the glucose homeostasis in blood, including defects shown as diabetes melittus (DM). 29 claims
Patent BG-104666-A (BG)
Title: Autonomous resonance inventories for dc-dc inverters of improved characteristics
Inventor: GRADINAROV NIKOLA P
IPC: H02M3/335
Filed: 2000-08-04
Abstract: The invention relates to resonance inverters for DC-DC inverters which have improved characteristics. This is due to the limitation of the voltage on the switching capacitor, which is achieved by dividing the load into two equal parts in the bridge circuitries, one side of the ends of which are connected to the middle parts of the two arms of the bridge, and the other two ends are interconnected by means of the switching capacitor (7), the voltage of which is limited to levels +Eo(-Eo). In charging the capacitor (7) to voltage +Eo(-Eo), the current which is received from the supply source (10) is discontinued, and the stored energy in the switching inductivities (8 and 9), which are coupled in the AC output circuit, is dissipated across the enabled diode, the respective half of the load and the operating switching instrument. The voltage limitation on the capacitor (7) enables the DC-DC inverters to have a favourable transition process of start-up and even to operate reliably in a short-circuit mode of the load. On the other hand, the connected in parallel of the inventor instruments groups of capacitor and diode, due to the special algorithm of control, wherein the duration of the controlling pulse exceeds the half-cycle of its own oscillations of the consecutive resonance circuit, ensure the operation of these instruments at zero switching, both of the current, and of the voltage. At an established mode, the limitation diodes are not put into operation and the circuitry operates as the known circuits of DC-DC inverters of zero switching of the current and the voltage. The circuitries limit the voltage of the switching capacitor in start-up or emergencies modes. The instruments of the inventor are included in three groups, consisting of diode and capacitor connected in parallel. 2 claims, 2 figures
Patent BG-107093-A (BG)
Title: A use of galantamine for the treatment of neuropsychiatric behaviour associated with alzheimer's disease
Inventor: PARYS WIM LOUIS J
IPC: A61P25/28
Filed: 2002-09-12
Abstract: Galantamine has been found to be safe and effective in the treatment of Alzheimer's disease. Neuropsychiatric disorders are often associated with Alzheimer's disease. It is demonstrated that Galantamine is reducing or stabilizing the incidence of neuropsychiatric behaviour seen in Alzheimer's patients. 11 claims, 5 figures
Patent BG-107115-A (BG)
Title: Lipopolysaccharides (lps) extracted from escherichia coli
Inventor: PROPPERT HANS
IPC: E21D20/00
Filed: 2002-09-18
Abstract: The invention relates to lipopolysaccharides extracted from E. coli DSM 6601. This LPS differs from the known LPS extracted from E. coli in particular with regard to the phosphorylated sugar moiety of the core and to the degree of polymerization of the O-chain. The A lipoid corresponds structurally and biologically to the classic type of E. coli. The inventive LPS is not only suitable for identifying the coli strain which carries it, but also provides the latter with a reduced pathogenic capability when retaining its immunomodulative effect. 6 claims
Patent BG-110572-A (BG)
Title: Device for recycling used oil
Inventor: ALEKSANDROV DIMITUR
IPC: C10M175/00
Filed: 2010-01-11
Abstract: The device can be applied in the recycling of used oil. It works in vacuum and consists of a heating device (1) and centrally and in-line situated above it fractionating column (2) with outlet pipes (3) for the ready fractions. The heating device (1) is constructed as a container with heaters (4), with injection nozzle (5) connected to the bottom part and outlet pipe (8) provided in the upper part. Directly above the heating device (1), there is an evaporator (6) shaped as sharply bevelled truncated cone with opening (7) in the bottom end, connected to the outlet pipe (8). The free volume of the heating device (1) is filled with metal pellets (9) and a stirring device is provided in it (10). A cleaning device (11) can be provided at the outlet pipe (8).
Patent BG-110591-A (BG)
Title: Aerodynamically stabilized munition
Inventor: TOMOV LYUBOMIR
IPC: F42B7/00
Filed: 2010-01-28
Abstract: The invention relates to an aerodynamically stabilized munition that can be used in small arms with grooved or smooth-bore barrels, with calibers up to 60 mm. The said munition consists of a body in the shape of a truncated cone (2) at the top part and a cylinder (6) in the lower part, with proportions of the cone part to the cylinder part varying from 1:6 to 1:3 depending on the initial speed ofthe munition for the specific embodiment, the munition has a central longitudinal aperture with a proportion of the entrance opening (1) and the exit opening (7) surfaces of 1.38 to 1 for sub-sound velocities, and proportions of 1.22 to 1 for hypersonic velocities, it also comprises nozzles (4) creating a spinning motion of the munition around its axis, as well as cavities (3 and 5) where the propellant charge is placed. The advantage of the munition lies in that the proposed design enables the rectilinear motion to be maintained by the aerodynamic forces which are created as a result of the motion of the munition and act during the whole flight of the munition. The friction between the bullet and the barrel to achieve spinning motion that is typically present, is now avoided, and the energy obtained as a result of the jet force acting during the combustion of the propellant is transformed into kinetic energy of the munition with virtually no waste.
Patent BG-110779-A (BG)
Title: Пружинен блок за мощностен превключвател на стъпален регулатор на напрежение
Inventor: GROZDANOV TONI
IPC: H01H9/00
Filed: 2010-10-22
Abstract: Пружинният блок е основна част от пружинно-енергиен акумулатор за мощностен превключвател на стъпален регулатор. Той осигурява скокообразно превключване на контактната система на мощностния превключвател. Предимството му е, че има голяма начална сила. Пружинният блок има два Т-образни носача (1, 2), стеблата на които (3, 4) са монтирани едно до друго. Към двете рамене на Т-образните носачи (1, 2) чрез накрайници (8, 9) са хванати пружини (10), работещи на опън. Аксиално на тях са монтирани вътрешни пружини (11), закрепени в единия си край към накрайника (8) на външната пружина (10), а в другия си край имат подвижен накрайник (12). Чрез аксиалния отвор на този накрайник (12) минава стебло (13), свързано в единия си край с втория накрайник (9). На втория си край стеблото (13) има глава (14), която може да приплъзва в по-голям отвор (15) на накрайника (12). По време на зареждане на пружинния блок Т-образният носач (1) е блокиран, а Т-образният носач (2) се предвижва аксиално и натяга външните пружини (10). След приплъзване на главата (14) в диапазона "х" започват да се опъват и вътрешните пружини (11) и по този начин се осъществява исканата стъпална силова характеристика.