baber/WOPTO huggingface dataset:
Patent CA-2386014-A1 (CA)
Inventor: HEHME NORBERT
IPC: A61K39/00
Filed: 2000-09-27
Abstract: L'invention concerne un vaccin monovalent contre la grippe comprenant une faible dose d'antigène du virus de la grippe dérivé de l'oeuf, d'une souche de virus associée à une pandémie ou ayant le potentiel d'être associée à une pandémie, combinée à un adjuvant aluminium. L'invention concerne également des kits de vaccins comprenant une combinaison de vaccins contre la grippe parentéraux et des muqueuses, dans lesquels la dose combinée d'antigène n'est pas supérieure à la dose d'antigène habituelle. L'invention concerne également des procédés de préparation des vaccins.
Patent CA-2386807-A1 (CA)
Title: Procede de preparation d'inhibiteurs cox-2
Inventor: CRUCIANI PAUL
IPC: C07C323/19
Filed: 2000-10-05
Abstract: Cette invention concerne un procédé de préparation de composés de formule générale (I) dans laquelle R1 est choisi parmi les groupes (a) OR5 et (b) phényle mono-, di-, ou tri-substitué; R2 représente un groupe (C1-C6)alkyle;  caractérisé en ce qu'il comprend les étapes suivantes: a) réaction d'un composé de formule générale (II): avec un acide de formule générale R1CH2 CO OH (III) en milieu anhydre, b) réaction du composé obtenu avec une base forte dans un solvant aprotique pour obtenir un composé cyclique intermédiaire qui , après déshydratation forme un composé de formule générale (I); et c) isoleme nt du composé de formule générale (I) ainsi obtenu.
Patent CA-2386876-A1 (CA)
Title: Combination chemotherapy
Inventor: KLOHS WAYNE DANIEL
IPC: A61P35/00
Filed: 2000-11-03
Abstract: Acetyldinaline in combination with paclitaxel and/or carboplatin is synergistic for treating cancer.
Patent CA-2389259-A1 (CA)
Inventor: MCCAULEY JOHN A
IPC: C07D401/06
Filed: 2000-10-26
Abstract: De nouveaux benzimidazoles, substitués dans la position 2 par des groupes benzyle ou des groupes hétéroaryle substitués, sont efficaces en tant qu'antagonistes de NMDA et NR2B, et sont utiles pour soulager la douleur.
Patent CA-2390284-A1 (CA)
Inventor: LYONS SHAWN L
IPC: A61K31/517
Filed: 2000-11-03
Abstract: Apparatus and method for preparing microparticles. An emulsion is formed by combining two phases in a static mixing assembly (730). The static mixing assembly preferably includes a preblending static mixer (732) and a manifold (734). The emulsion flows out of the static mixing assembly into a quench liquid whereby droplets of the emulsion form microparticles. The residence time of the emulsion in the static mixing assembly is controlled to obtain a predetermined particle size distribution of the resulting microparticles.
Patent CA-2392588-A1 (CA)
Title: Blend for masterbatches
Inventor: MLINARIC JEAN-MARIE
IPC: C08L51/04
Filed: 2000-12-07
Abstract: Provided is a blend comprising: a) from 20 to 60 wt% of a thermoplastic elastomer; b) from 8 to 30 wt% of a vinylaromatic polymer; c) from 10 to 30 wt% of one or more processing aid; d) from 0 to 20 wt% of one or more additives.
Patent CA-2393091-A1 (CA)
Inventor: AUGER RICHARD
IPC: A01G9/28
Filed: 2002-07-11
Abstract: Une membrane perméable à l'eau et capable de faire barrière par des moyens purement mécaniques, à la croissance des racines d'arbres et d'herbacés.  Cette membrane comprend n couches de non-tissé ayant une épaisseur prédéterminée et n+1 couches de matériel imperméable percé de trous pour permettre le drainage de l'eau, où n est un nombre entier égal ou supérieur à 1. Les deux types de couches alternent d'un-type-à l'autre de façon à ce que deux des couches faites de matériel imperméable forment des couches externes à la membrane, et chaque couche de non-tissé se retrouve entre deux couches du matériel imperméable.
Patent CA-2393868-A1 (CA)
Inventor: GATNAREK BRUCE
IPC: B61F5/14
Filed: 2002-07-16
Abstract: A railway truck side bearing with multi-purpose mounting points for securing the bearing cage to a railway truck bolster, such that one of the mounting points can serve a dual function of locating a resiliently deformable bearing element in the bearing cage and permitting positioning of a rigid bearing element within the bearing cage midway between the mounting points, which may also correspond to the bolster centerline.
Patent CA-2395196-A1 (CA)
Inventor: GAUDINO JOHN J
IPC: A61P31/04
Filed: 2000-12-15
Abstract: Novel compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
Patent CA-2395267-A1 (CA)
Inventor: SCHNEIDER HERMANN
IPC: A01N43/60
Filed: 2000-11-11
Abstract: L'invention concerne de nouveaux dérivés de pyrrole représentés par la formule (I), dans laquelle X représente oxygène ou soufre ; R¿1? représente hydrogène, alkyle en C¿1?-C¿4? non substitué ou substitué, ou halogène ; R¿2? est alkyle en C¿1?-C¿4? non substitué ou substitué ; et A est aryle substitué en ortho ; hétéroaryle substitué en ortho ; bicycloaryle non substitué ou substitué ; ou bicyclohétéroaryle non substitué ou substitué. Les nouveaux composés possèdent des propriétés de protection des plantes et conviennent pour protéger des plantes contre des infestations par des micro-organismes phytopathogènes.
Patent CA-2395490-A1 (CA)
Title: Repressible sterility of animals
Inventor: HARDY CHRIS
IPC: A01K67/027
Filed: 2000-12-22
Abstract: A construct which allows animals to be bred in captivity but renders them infertile in the wild by allowing reversible control over fertility and reproduction. The construct comprises: a first promoter that is activated in a defined spatial (tissue specific) or temporal manner linked to DNA encoding a transactivating protein; and a second promoter, which is activated by the transacting protein, linked to DNA encoding a blocker molecule which disrupts gametogenesis or embryogenesis. Feeding an animal a molecule that prevents the transactivating protein binding the second promoter controls fertility.
Patent CA-2396594-A1 (CA)
Title: Pressure seal c-z fold mailer
Inventor: STEITZ JEREMY W
IPC: B65D27/16
Filed: 2000-12-19
Abstract: A mailer type business form intermediate (10), and method of producing a mailer from the intermediate to produce a business form that is particularly advantageous for providing a negotiable instrument. The intermediate has fold lines defining a sheet of paper comprising the intermediate into first through fourth panels (26, 27, 28, 29). The fourth panel (29) has indicia defining the negotiable instrument and at least one line of weakness separating the negotiable instrument from the rest of the fourth panel. Tacking adhesive patterns may be disposed substantially parallel to the top and bottom edges (13, 14) of the intermediate to hold the first panel second face to the second panel second face adjacent the top edge and second fold line, and to hold the fourth panel second face to the second panel first face adjacent the first and third fold lines, when the intermediate is folded about the fold lines.
Patent CA-2397991-A1 (CA)
Inventor: VANMECHELEN EUGEEN
IPC: G01N33/50
Filed: 2001-01-18
Abstract: The present invention provides a method for the diagnosis of tauopathies in an individual and/or for the differential diagnosis of a tauopathy versus a non-tauopathy based on the detection of the ratio of phospho-tau (181)/ total tau in said individual. The present invention further provides a phospho-peptide for standardization in a method of the invention.
Patent CA-2398564-A1 (CA)
Inventor: POLICKY JENNIFER L
IPC: C07K14/72
Filed: 2001-01-26
Abstract: The invention provides human nuclear hormone receptors (NHREC) and polynucleotides which identify and encode NHREC. The invention also provides  expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with aberrant expression of NHREC.
Patent CA-2400979-A1 (CA)
Inventor: IKEMOTO TOMOMI
IPC: C07D225/06
Filed: 2001-02-20
Abstract: L'invention porte sur un procédé sûr de production en masse selon un cycle court de composés cycliques à usage médical, agricole, chimique, alimentaire et cosmétique, et sur des produits chimiques leurs servant d'intermédiaires. Lesdits composés (ou leurs sels) sont représentés par la formule (I) {dans laquelle Z représente un groupe attracteur d'électrons; W représente éthylène ou vinylène facultativement substituées; R?3¿ représente H ou un groupe hydrocarboné facultativement substitué; et X représente un groupe divalent [pour autant que W représente vinylène facultativement substitué auquel cas, -X-CH¿2? n'est pas X?1¿-X?2¿-CH¿2?-Z (où X?1¿ représente S ou N facultativement substitué, et X?2¿ représente éthylène facultativement substitué)]}, consistant à soumettre un composé représenté par la formule (II) (dans laquelle les symboles ont le même sens que ci-dessus) à une réaction de fermeture de cycle dans un solvant contenant un diester carbonique.
Patent CA-2401844-A1 (CA)
Title: Improvements in or relating to fire-fighter training
Inventor: HOUGH STEPHEN JOHN
IPC: G09B9/00
Filed: 2001-03-01
Abstract: A fire simulator comprises fuel distribution means under a grating through which fuel emanating from the fuel distribution means can rise in use to create flames extending above the grating, wherein the grating includes a plurality of grating elements that together define a walkable working surface for a fire-fighter using the simulator.
Patent CA-2401881-A1 (CA)
Title: Method and apparatus for measuring calcium oxalate scaling
Inventor: SHEVCHENKO SERGEY M
IPC: G01N27/416
Filed: 2001-02-23
Abstract: The invention relates to an apparatus for measuring the calcium oxalate scale forming propensity of a continuously flowing solution having a pH of from 2 to 3 which comprises a quartz crystal microbalance having a top side comprising a working electrode for exposure to the solution and a bottom side isolated from the solution, wherein the working electrode is coated with or made of a conductive material on which the intensive evolution of hydrogen gas proceeds at potentials more negative than necessary to achieve a pH of 3.5-9 proximate to the microbalance.
Patent CA-2401989-A1 (CA)
Inventor: BUTZKUEVEN HELMUT
IPC: A61K38/00
Filed: 2001-03-02
Abstract: D'une manière générale, la présente invention concerne une méthode de traitement ainsi que des agents destinés à cette méthode. Plus particulièrement, cette invention se rapporte à une méthode permettant de traiter et/ou de prévenir une maladie du système nerveux, une maladie démyélinisante et/ou une maladie inflammatoire du système nerveux central ou périphérique, telle qu'un état pathologique encéphalopathique, et notamment un état pathologique encéphalomyélopathique. La présente invention concerne également l'utilisation d'un facteur inhibant les cellules leucémiques ou de ses dérivés, homologues ou analogues dans l'élaboration d'un médicament destiné à traiter et/ou prévenir une maladie du système nerveux, une maladie démyélinisante et/ou une maladie inflammatoire du système nerveux central ou périphérique, telle qu'un état pathologique encéphalopathique, et notamment un état pathologique encéphalomyélopathique. Ce facteur inhibant les cellules leucémiques peut être utilisé séparément ou en combinaison avec une ou plusieurs molécules thérapeutiques, telles que d'autres cytokines. La méthode de la présente invention permet le développement d'un protocole thérapeutique destiné aux états pathologiques tels que la sclérose en plaques, la névrite optique et autres épisodes isolés liés à la démyélinisation centrale, la myélite transverse, la leucoencéphalopathie induite par le VIH ou la leucoencéphalopathie induite par la chimiothérapie.
Patent CA-2405672-A1 (CA)
Inventor: CHANG CHIA-BO
IPC: F16K27/04
Filed: 2002-09-30
Abstract: A faucet comprises two valve seats back-to-back, and a ceramic control valve assembled with an assembly slot of the two valve seats.        The assembly slot is provided on a central horizontal line thereof with a cold water guide hole arid a hot water guide hole, and on a central vertical line thereof with an upper discharging hole and a lower discharging hole. A base of the ceramic control valve is provided on a central horizontal line thereof with a cold water admission hole, and a hot water admission hole. The base is further provided with a water discharging hole which is located across a central vertical line of the base such that the water discharging hole is opposite in location to the lower discharging hole of the assembly slot. The base is provided with a water stopping surface located on the central vertical line of the base.
Patent CA-2405942-A1 (CA)
Inventor: BERNI ANETTE
IPC: C03C17/25
Filed: 2001-04-12
Abstract: Method for the production of substrates comprising a layer consisting of inorganic gel, glass, vitroceramic or ceramic material, according to which a  coating composition containing nanoscalar particles and water-soluble organi c flexibilizers is applied to the substrate and is thermally treated. Said method allows transparent thick films which are devoid of cracks to be obtained. The coated substrates are particularly suitable for use as optical , optoelectronic, electronic, micromechanical or dirt-repellent components.</S DOAB>
Patent CA-2406997-A1 (CA)
Inventor: GUYON YVAN
IPC: A23L2/38
Filed: 2002-10-08
Abstract: A process for preparing a beverage from maple sap or concentrates thereof, comprising obtaining maple syrup of the maple sap and diluting the syrup with water in order to obtain a syrup-water solution containing a predetermined concentration of maple syrup. The solution is then purified from of any impurities and pathogens.      Preservatives are added to the solution. The solution is then carbonated and enclosed in a container to be served.
Patent CA-2407671-A1 (CA)
Inventor: DUHAMEL GERALD
IPC: A63F1/00
Filed: 2001-05-02
Abstract: L'invention concerne un procédé destiné à jouer à un jeu de cartes dans lequel les joueurs doivent deviner si plusieurs cartes consécutives ont une valeur supérieure ou inférieure à la précédente. Un mode de réalisation particulier de ce jeu consiste à jouer sur un dispositif de jeu électronique comme un jeu secondaire dans lequel les gains du jeu primaire sont utilisés afin de financer les paris du jeu secondaire. L'affichage de jeu préféré consiste à présenter sur une seule rangée les treize (13) cartes d'une même suite d'un jeu de carte ordinaire, les treize (13) cartes étant dissimulées, et de retourner la première carte sur la gauche lorsque le joueur a décidé de jouer. Le joueur doit deviner si la carte suivante sera d'une valeur inférieure ou supérieure à la carte retournée. Si le joueur parvient à deviner juste les treize (13) cartes, il gagne un lot.
Patent CA-2408252-A1 (CA)
Title: Method and apparatus for pre-emptively arbitrating on an acyclic directed graph
Inventor: OPRESCU FLORIN
IPC: G06F13/42
Filed: 1993-12-16
Abstract: A bus arbitration scheme is implemented in a system where an arbitrary assembly of nodes on a system bus have been resolved into an acyclic directed graph. The hierarchical arrangement of nodes has one node designated a root while all other nodes have established parent-child relationships with the nodes to which they are linked.      Each node may have a plurality of connected child ports with a predetermined acknowledgment priority scheme established. Fair bus access arbitration provides for bus granting in a sequence corresponding to the predetermined port priorities allowing all nodes a turn on the bus. The root node may always assert its priority access status to gain bus access which is useful for accommodating a root node which requires isochronous data transfer.      Alternatively, a token passing arbitration scheme may be implemented where the token for bus access is passed around the nodes according to the above-described predetermined port priority scheme. Preemptive bus initialization may be triggered by any node upon detection of a necessitating error or addition or removal of a connection to an existing node.
Patent CA-2408376-A1 (CA)
Title: Battery monitoring system
Inventor: GARRETT DALE B
IPC: H02J7/00
Filed: 2001-05-01
Abstract: A power distribution system is provided comprising a power regulator, a battery circuit, and a battery monitoring system. The power converter is provided for converting AC power to DC power and for providing DC power to a load. The battery circuit is coupled to the power regulator and the load and is operable to recharge by receiving DC power from the power regulator. The battery circuit is also operable to supply DC power to the load when there is an interruption of power from the load. The battery monitoring system comprises a field measurement device located in close proximity to the battery circuit, the field measurement device including an input mechanism for receiving current measurement data and an analog-to-digital converter for digitizing the received current measurement data. The battery monitoring system further comprises a monitor located remotely from the field measurement device, the monitor including a first communicator for receiving digitized data from the field measurement device.
Patent CA-2408499-A1 (CA)
Title: Flexible shunt for electric power switch
Inventor: CROOKSTON RONALD W
IPC: H01H1/58
Filed: 2001-05-07
Abstract: A flexible shunt (23) in the form of a flexible member (25) made up of a stack of electrically conductive laminations (27) each of a thickness of no more than about 0.002 inch (0.051 mm) has a moveable end (25m) secured by a moveable mount (29) to a moveable contact support of an electric power switch for movement along a linear path (17). A fixed mount (37) secures the fixed end (25f) of the flexible member (25) to a fixed conductor termination (21) spaced laterally from the moveable end (25m) along a neutral axis perpendicular to the linear path (17) of the moveable end (25m) by an offset distance (j) such that the installed length (f) of the intermediate section (25i) between the fixed and moveable ends is less than the free length (f) of the intermediate section (25i). With this arrangement the stroke (55) of the moveable end along the linear path (17) can be up to at least 1/3 and even 1/2 of the free length (f) of the intermediate section (25i) of the flexible member (25) and with very low operating forces.
Patent CA-2408585-A1 (CA)
Title: Apparatus and methods for improved noninvasive dermal administration of pharmaceuticals
Inventor: ZHANG JIE
IPC: A61F13/00
Filed: 1996-07-26
Abstract: An apparatus, product formulation, and method for improved dermal permeation of pharmaceuticals wherein the apparatus includes a thin drug formulation reservoir and a heat-generating chamber separated by a first non-permeable wall, wherein the reservoir and chamber are formed in or supported by a housing. The drug formulation reservoir houses or is capable of housing a predetermined amount of a formulation containing pharmaceutically-active agent(s). The heat-generating/temperature-regulating chamber includes a medium for generating controlled heat, preferably a chemical composition made of carbon, iron, water and/or salt which is activated upon contact with air (oxygen). The function of the heat-generating/temperature-regulating element is to heat the user's skin, rapidly bring the skin temperature to a desired and elevated narrow range and keep it in this range for sufficient time to obtain more rapid, enhanced and less variable dermal absorption of selected pharmaceutically-active agents and to obtain improved clinical effects.  Structure for controlling the generation of heat is also disclosed. The apparatus may optionally include a spacing or standoff structure which spans the drug formulation reservoir between the non-permeable wall and the user's skin surface for maintaining a predetermined thickness of the drug formulation on the user's skin surface. Also, a novel product formulation which can be used with the apparatus which uses high percentage of eutectic mixture of local anesthetics to reduce the overall degradation rate of the local anesthetic compound(s) in formulations which are subject to hydrolysis.
Patent CA-2408606-A1 (CA)
Title: Drug combinations useful for prevention of restenosis
Inventor: KOPIA GREGORY A
IPC: A61K31/436
Filed: 2001-04-25
Abstract: The current invention comprises an approach to solving the clinical problem of restenosis, which involves the administration of combinations of drugs to patients undergoing PTCA or stent implantation. In one embodiment of the invention, an antiproliferative agent such as rapamycin, vincristine or taxol is administered in combination with the anti-inflammatory agent, dexamethasone, to patients systemically, either subcutaneously or intravenously. In another embodiment of the invention, the antiproliferative and anti-inflammatory agents are bound in a single formulation to the surface of a stent by means of incorporation within either a biodegradeable or biostable polymeric coating. Alternatively, such drug combinations could be incorporated into a stent constructed with a grooved reservoir.
Patent CA-2411242-A1 (CA)
Title: Apparatus and method for monitoring of oxidative gas or vapor
Inventor: LIN SZU-MIN
IPC: G01N25/28
Filed: 2002-11-04
Abstract: An apparatus for monitoring the concentration of an oxidative gas or vapor includes a first thermocouple junction and a chemical substance coupled to the first thermocouple junction. The chemical substance is reactive with the oxidative gas or vapor to produce heat. The apparatus further includes a second thermocouple junction coupled in series to the first thermocouple junction. A net voltage is generated across the first and second thermocouple junctions upon exposure of the chemical substance to the oxidative gas or vapor. The net voltage corresponds to the concentration of the oxidative gas or vapor.
Patent CA-2412385-A1 (CA)
Inventor: CHAPMAN CLINTON D
IPC: E21B47/00
Filed: 2002-11-22
Abstract: La présente invention offre une méthode graphique pour concevoir et modifier la trajectoire d'un puits de forage. Un plan de la trajectoire de forage comporte des sections de stabilisation et de courbure. Les sections de stabilisation sont généralement décrites en spécifiant l'attitude de la stabilisation et la longueur de la stabilisation. Les sections de courbure peuvent être décrites et représentées de façons différentes. La présente invention présente des points de contrôle qui sont formés à l'intersection des extensions/projections des deux sections de stabilisation entrant en contact avec une section de courbure. Les sections de stabilisation entrent en contact avec la section de courbure à des points de tangence. Les points de tangence pour une section de courbure ont la même distance jusqu'au point de contrôle. En opération, quand un point de contrôle est déplacé, l'orientation et l'inclinaison de plusieurs sections du plan de puits sont simultanément modifiées. Ces modifications simultanées permettent à l'utilisateur de modifier un plan de puits de manière rapide et intuitive.