baber/WOPTO huggingface dataset:
Patent CA-2774919-A1 (CA)
Title: Dosage regimen for administering a cd19xcd3 bispecific antibody
Inventor: NAGORSEN DIRK
IPC: A61K39/395
Filed: 2010-10-27
Abstract: The present invention relates to a method for assessing (analyzing) the risk of potential adverse effects for a human patient mediated by the administration of a CD19xCD3 bispecific antibody to said patient comprising determining the ratio of B cells to T cells of said patient, wherein a ratio of about 1:5 or lower is indicative for a risk of potential adverse effects for said patient. Accordingly, the present invention relates a method (dosage regimen) for administering a CD19x CD3 bispecific antibody to a human patient having a B :T cell ratio of about 1:5 or lower, comprising (a) administering a first dose of said antibody for a first period of time; and consecutively (b) administering a second dose of said antibody for a second period of time, wherein said second dose exceeds said first dose.In some embodiments, a third dose of said antibody is administered for a third period of time. This dosage regimen can be applied in methods for treating malignant CD19 positive lymphocytes or for ameliorating and/or preventing an adverse effect mediated by the administration of said bispecific antibody. The present invention also relates to the use of a CD19x CD3 bispecific antibody for the preparation of a pharmaceutical composition to be used in a method of the present invention. A pharmaceutical package or kit comprising a first dose and a second dose and optionally a third dose of said antibody as defined in the methods/dosage regimen of the present invention is disclosed as well.
Patent CA-2775047-A1 (CA)
Inventor: BUNICK FRANK J
IPC: A61J3/10
Filed: 2010-09-23
Abstract: The present invention features the present invention features a process for making a tablet by compacting a powder blend in a die platen to form a tablet shape, wherein the powder blend includes a pharmaceutically active agent and a water-containing material, and applying energy to the tablet shape for a sufficient period of time to heat the water- containing material within the tablet shape above its dehydration temperature to form the tablet.
Patent CA-2776259-A1 (CA)
Title: Attachable/detachable reamer head for surgical reamer
Inventor: GREEN JAMES M
IPC: A61M1/00
Filed: 2002-11-20
Abstract: A device for expedited reaming of a medullary canal having a detachable reaming head is disclosed. The device includes a reamer head connected at the distal end of a rotatable drive shaft. The reamer head has a cutting head with a plurality of blades and flutes therebetween at a first end and a plurality of resilient arms at a second end. The device may also includes an aspiration tube which fits over the rotatable drive shaft and a reamer head retainer which rotatably engages the reamer head. In addition, the reamer head may be detached from the reamer device for future re-use by using a reamer head removing device.
Patent CA-2778032-A1 (CA)
Title: Solid ink compositions comprising semicrystalline oligomer resins
Inventor: CARLINI RINA
IPC: C09K23/00
Filed: 2012-05-25
Abstract: A solid ink composition comprising oligomer resins which are suitable for direct-to-paper (DTP) and/or transfix inkjet printing. In embodiments, the oligomer resins are poly/oligoester and poly/oligoesteramide compounds, which are non-wax materials having semi-crystalline properties.
Patent CA-2778560-A1 (CA)
Inventor: YANO HIROYUKI
IPC: C08L1/00
Filed: 2010-10-21
Abstract: This invention provides a polyolefin-based molded article containing microfibrillated plant fibers having high strength and high elastic modulus. Specifically, the present invention provides a composition comprising (1) a polymeric compound having a primary amino group, (2) a polymeric compound modified with maleic anhydride, (3) microfibrillated plant fibers, and (4) a polyolefin; and a molded article obtained by subjecting the composition to heat treatment.
Patent CA-2781078-A1 (CA)
Title: Process for isomerizing a hydrocarbonaceos feedstock using aluminosilicate zsm-12
Inventor: BURTON ALLEN W
IPC: B01J29/70
Filed: 2010-11-19
Abstract: An aluminosilicate ZSM-12 may be prepared de novo in a small crystalline form from a reaction mixture containing a source of silica and a source of alumina. A small crystalline form of aluminosilicate ZSM-12 may also be prepared from a small crystalline form of borosilicate ZSM-12 by replacement of boron in the borosilicate ZSM-12 framework with aluminum. The aluminosilicate ZSM-12 is useful as an isomerization selective catalyst in processes such as isomerization dewaxing hydrocarbon feedstocks.
Patent CA-2782513-A1 (CA)
Inventor: SHALEV ALON
IPC: A61F2/06
Filed: 2010-12-02
Abstract: A stent-graft (20) is provided, which is configured to initially be placed in a delivery shaft (40) in a radially-compressed state, and which comprises a support structure (36) and a covering element (38). The support structure (36) has proximal and distal ends, and is shaped so as to define at least a coupling portion (30), which 5 is configured to transition to a partially-radially-expanded state upon deployment of the stent-graft (20) from the delivery shaft (40), in which state the coupling portion (30) defines a sharp tip (34) at the proximal end of the support structure (36). The covering element (38) is securely attached to and covers at least a portion of the support structure (36). A 10 coupling-end expansion tool (100) is configured to transition the coupling portion (30) from the partially-radially-expanded state to a more-radially-expanded state. Other embodiments are also described.
Patent CA-2783854-A1 (CA)
Inventor: JACOBSEN JON E
IPC: F03B3/18
Filed: 2012-07-27
Abstract: A method for refurbishing wicket gates by applying a sheet material to at least a portion of the vane surface of the wicket gate, thus forming a new face. This sheet material may be applied by wrapping the sheet material around the vane surface.  The method may further include applying sheet material to the end surfaces of the wicket vane. If end material is applied, it may be sealed to the sheet material of the vane surface.
Patent CA-2784736-A1 (CA)
Title: High silica chabazite for selective catalytic reduction, methods of making and using same
Inventor: LI HONG-XIN
IPC: B01D53/94
Filed: 2010-11-02
Abstract: There is disclosed a microporous crystalline material comprising a metal containing chabazite having a crystal size greater than 0.5 microns and a silica-to- alumina ratio (SAR) greater than 15, wherein the metal containing chabazite retains at least 80% of its initial surface area and micropore volume after exposure to temperatures of up to 900°C in the presence of up to 10 volume percent water vapor for up to 1 hour. Methods of using the disclosed crystalline material, such as in the SCR of NOx in exhaust gas are also disclosed, as are methods of making such materials.
Patent CA-2787807-A1 (CA)
Title: Incinerator fly ash geopolymer and method
Inventor: ALLOUCHE EREZ NISSIM
IPC: C04B28/02
Filed: 2012-08-27
Abstract: A geopolymer concrete formed by mixing about 3% to about 43% by weight incinerator fly ash, about 3% to about 35% by weight coal fly ash, about 7% to about 38%  by weight alkaline activator liquid, and about 31 % to about 70% by weight aggregate.  The incinerator fly ash may be derived from a solid waste incinerator facility. The alkaline activator liquid may include a sodium hydroxide solution and sodium silicate.  The aggregate may include a fine aggregate, such as sand, and a coarse aggregate, such as gravel.
Patent CA-2788664-A1 (CA)
Title: Processing system for processing specimens using acoustic energy
Inventor: OTTER MICHAEL
IPC: G01N29/024
Filed: 2011-03-04
Abstract: A method for fixing a biological sample includes delivering energy through a biological sample that has been removed from a subject, while fixing the biological sample. A change in speed of the energy traveling through the biological sample is evaluated to monitor the progress of the fixation. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy. A computing device can evaluate the speed of the energy based on signals from the receiver.
Patent CA-2790126-A1 (CA)
Title: Improved systems and methods for disengaging and engaging a wrap spring clutch
Inventor: BARRY ALAN F
IPC: F16D13/02
Filed: 2011-02-17
Abstract: The invention provides a system, device and method for using a rotary actuator, e.g., a stepper motor to actuate a wrap spring clutch. Feedback from a system of sensors and GPS data, including rotational speed, travel speed and direction are provided to improve the reaction accuracy of the clutch. In one embodiment, a plurality of actuator controllers are connected in a configuration wherein one controller is a "master" and the remaining controllers are "slaves" to provide a higher level of machine control.
Patent CA-2790548-A1 (CA)
Title: Wellbore cementing tool having outwardly biased locking members
Inventor: GRAINGER ROBERT
IPC: E21B33/13
Filed: 2012-09-24
Abstract: A wellbore cementing tool configured for placement in a drill string, and method of using same. The tool is lowered on a hollow, small-diameter stem into the drill string and contacts the bit, such that the downward pressure on the tool causes a shear pin to shear, resulting in upward movement of an outer sleeve relative to the central body of the tool. The outer sleeve normally holds outwardly biased locking members in a retracted position, but when the outer sleeve is upwardly displaced, slots in the outer sleeve align with the locking members and allow the locking members to extend outwardly through the slots to engage the inner wall of the drill string thereby locking the tool in place. When in position, cement can be injected through the tool and the bit, circulating up the wellbore annulus. The tool does not require rotation to engage the drill string. hence reducing the risk of loosening the threaded connections of lengths of drill pipe.
Patent CA-2792399-A1 (CA)
Inventor: NARASIMHAN KALATHUR S
IPC: H01F1/24
Filed: 2011-03-29
Abstract: The present invention is directed to electrically conductive compacted metal parts fabricated using powder metallurgy methods. The iron-based powders of the invention are coated with magnetic or pre-magnetic materials.
Patent CA-2792841-A1 (CA)
Title: Method for controlling and/or regulating a metering pump
Inventor: FREUDENBERGER THOMAS
IPC: F04B49/02
Filed: 2011-03-21
Abstract: The present invention relates to a method for controlling and/or regulating a metering pump having a drive motor having a shaft driven by the motor, and a displacement member disposed in a metering head, wherein the rotary motion of the shaft is converted into an oscillating motion of the displacement member, wherein the displacement member interacts with an outlet and inlet valve, leading to a pump stroke (pressure stroke) and an intake stroke and thus to delivering a metered medium. In order to disclose a method for controlling and/or regulating a metering pump operating principally without a position sensor on the pushrod, and that can highly precisely determine the metering behavior of the pump, according to the invention at least one motor operating parameter, preferably a motor voltage U or a motor current I, is measured, at least one control parameter is calculated from the measured motor operating parameters and optionally further known motor characteristics are calculated, the at least one control parameter is compared to a predetermined guide parameter, and a comparison signal depending on the result of the comparison is output and can be used as a status, actuating, and/or regulating signal.
Patent CA-2797235-A1 (CA)
Title: Steam turbine, blade, and method
Inventor: GRILLI MARCO
IPC: F01D9/04
Filed: 2012-11-29
Abstract: A stator blade ring for the last stage of a multi-stage steam turbine includes a plurality of stator blade modules defining an annular chamber, each stator blade module including an elongated blade portion. The elongated blade portion further includes a longitudinal passageway and an inner portion brazed to a first longitudinal end of the blade portion, the inner portion including a through hole forming a portion of the annular chamber and an inner passageway extending from the through hole to the longitudinal passageway. An outer portion is brazed to a second longitudinal end of the blade portion and engaged to the steam turbine. The outer portion includes an outer passageway open to a surface of the steam turbine and the longitudinal passageway.
Patent CA-2797743-A1 (CA)
Inventor: PALMER ROSS
IPC: C02F1/52
Filed: 2011-04-29
Abstract: The invention provides a method for treating a swimming pool, the method including the step of introducing Mg2+ to a level from 60 ppm to 300 ppm to the swimming pool by addition of a soluble magnesium compound to the swimming pool, or Mg2+ to a level from 60 ppm to 1000 ppm by addition of a magnesium halide in addition to a further soluble magnesium compound.
Patent CA-2798221-A1 (CA)
Title: Method and guidance-unit for guiding transportation means with batteries to reconditioning stations
Inventor: PETTERSSON BO
IPC: G01C21/34
Filed: 2011-04-27
Abstract: A method, unit and a computer program product for guiding a mobile transportation means of a set of transportation means, each having associated therewith a powering battery of a set of batteries, to a selected reconditioning station of a set of reconditioning stations, in a geographically distributed arrangement of the transportation means and the reconditioning stations. The selected reconditioning station is assigned to the transportation means for charge or substitution of the powering battery, which is located within the range of mobility of the transportation means along a path to a desired target. The transportation means is guided to the selected reconditioning station, wherein an optimisation of the assignment and/or the path is executed by a search algorithm for assigning the set of transportation means to the set of reconditioning stations and batteries, based on actual and/or forecasted information about multiple entities of the sets of transportation means, stations and batteries as well as their conditions.
Patent CA-2798537-A1 (CA)
Title: Reduced fossil fuel in an oxidizer downstream of a biomass furnace
Inventor: CASH JAMES T
IPC: B01D53/44
Filed: 2011-07-05
Abstract: Method of extracting syngas between the zone in a furnace where oxygen-starved combustion of biomass occurs and the zone in the furnace where secondary air is added to complete combustion, conditioning and cleaning the extracted syngas, and delivering it in a metered amount to the oxidizer or upstream of the oxidizer to reduce or eliminate the need for additional fossil fuels once the oxidizer has achieved its operating temperature. The gasifier or furnace burns solid waste and produces a syngas containing relatively high levels of CO, which is extracted from the furnace, conditioned, and introduced into an RTO as a fuel source. In certain embodiments, no extraction of syngas from the furnace takes place; the furnace conditions are manipulated so that normally undesirable levels of CO and other VOC's remain in the process stream. The heat from the furnace is used as intended (e.g., to heat a dryer), the stream is conditioned, and ultimately proceeds to a downstream RTO. Since the gas stream remains rich in CO and VOC's, its fuel value in the RTO is substantially higher than otherwise would be the case.
Patent CA-2799968-A1 (CA)
Title: Device and method for denoising ocean bottom data
Inventor: POOLE GORDON
IPC: G01V1/36
Filed: 2012-12-21
Abstract: Computing device, computer instructions and method for denoising marine seismic data recorded with first and second seismic sensors. The method includes receiving first seismic data recorded with the first sensor in a time-space domain; receiving second seismic data recorded with the second sensor in the time-space domain, wherein the first and second seismic data are recorded at the same locations underwater; calculating with a processor models of the first and second seismic data in a transform domain that is different from the time-space domain; performing a wavefield separation using the first and second datasets in the transform domain; determining a noise in the transform domain corresponding to the second seismic data based on the wavefield separation;  reverse transforming the noise from the transform domain into the time-space domain; and denoising the second seismic data by subtracting the noise in the time-space domain from the second seismic data.
Patent CA-2801091-A1 (CA)
Inventor: POULIN STEPHANE
IPC: E04G13/06
Filed: 2012-12-31
Abstract: The present invention provides a system for use in formwork for building concrete stairs which is durable and reusable, which can be rapidly mounted and dismantled on site and which is adjustable to a variety of flight of stairs having different widths, rises and pitches. The system comprises (a) at least one side plate which can be fastened to a stringer; to form the side of a tread, the side plate defining the depth of the tread; (b) a riser plate for defining the rise of a stair; and (c) means for fastening the riser plate to the side plate; wherein the side plate and riser plate are reusable and wherein the side plate can be adjusted to build treads of varying depths.
Patent CA-2801761-A1 (CA)
Inventor: IRION ALLAN
IPC: E01B27/02
Filed: 2012-12-27
Abstract: A cribbing work head including a work head frame having a longitudinal extent and a lateral extent. At least two inverted U-shaped work arms are mounted parallel to one another on the work head frame and spaced longitudinally from each other for lateral reciprocating movement on the frame, each of the work arms having a replaceable tool secured to each free end of the inverted U-shaped work arm. A separate fluid power double cylinder is secured to the work head frame and to each of the inverted U-shape work arms for independently laterally reciprocating the work arms. A main cylinder of each of said fluid power double cylinders is operable to laterally reciprocatingly move a respective work arm and a secondary cylinder of each of the fluid power double cylinders operable to move a respective work arm to one of two discrete lateral starting points.
Patent CA-2801993-A1 (CA)
Title: Perforating gun and method of perforating a well
Inventor: RICHARDS ANDY
IPC: E21B43/1185
Filed: 2011-05-19
Abstract: A perforating gun (50) for use in a wellbore comprises a body (52) configured to be displaced within the wellbore, and first and second charge arrangements mounted on the body (52) and configured to be detonated independently of each other. In one embodiment the body (52) is configured to be moved axially within the wellbore between detonation of the first and second charge arrangements and at least portions of the first and second charge arrangements are provided within a common axial length of the body (52).
Patent CA-2803069-A1 (CA)
Inventor: BARRETTO PETER
IPC: B32B21/04
Filed: 2010-01-21
Abstract: Provided is a composite bonded leather material. The material may be used as flooring, for wall applications or for ceiling applications. A leather layer is bonded to a substrate layer using adhesive. The substrate layer may be agglomerated cork or wood fiber. The leather layer may be textured or may be prefinished.
Patent CA-2803813-A1 (CA)
Inventor: OHASHI NAOKI
IPC: C25B9/23
Filed: 2011-07-01
Abstract: A carbon black (CB)/PTFE composite porous sheet which can be used as the gas diffusion layer of a polymer electrolyte membrane fuel cell or of an electrochemical device for electrolysis or for an application which is accompanied by an electrochemical reaction, such as a gas sensor, is difficult to handle because the porous sheet is flexible and hence is apt to wrinkle or crease. Provided is a method for easily handling the sheet while preventing the sheet from wrinkling or creasing. The method is for laminating a composite sheet comprising functional particles and polytetrafluoroethylene (PTFE) to a membrane electrode assembly (MEA) and comprises: preparing the MEA; preparing the composite sheet; preparing a release film; superposing the composite sheet on the release film and pressing the stack at ordinary temperature; superposing the composite sheet which has been pressed against the release film at ordinary temperature, on the MEA and hot-pressing the resultant stack; and peeling the release film from the composite sheet.
Patent CA-2805369-A1 (CA)
Title: Measuring apparatus
Inventor: ONISHI KENICHI
IPC: G01M15/06
Filed: 2013-01-09
Abstract: A measuring apparatus includes a sensor unit that includes a coil and a conductive cylinder arranged such that an area of an overlap zone varies as a position of an object changes; a capacitor and a resistor that make up a series circuit with the coil; a voltage applier that applies an input voltage Vi to the series circuit; a phase detector that detects a phase of a voltage Vo across the capacitor; a magnitude detector that detects a magnitude of the voltage Vo; feature data in which the phase, the magnitude, a temperature of the sensor unit, and an area of the overlap zone are associated with one another; and a calculator that calculates the temperature and the area based on the feature data using the phase and the magnitude detected by actual measurement of the voltage Vo.
Patent CA-2805770-A1 (CA)
Inventor: GEWEHR MARKUS
IPC: A01P3/00
Filed: 2011-08-22
Abstract: The present invention relates to an agrochemical mixture for increasing the health of a plant, comprising as active compounds: 1) a fungicidal compound (I) selected from the group of strobilurins consisting of pyra- clostrobin, azoxystrobin, dimoxystrobin, enestroburin, fluoxastrobin, kresoxim-methyl, metominostrobin, orysastrobin, picoxystrobin, pyribencarb, trifloxystrobin, pyrametostrobin, pyraoxystrobin, coumoxystrobin, coumethoxystrobin, triclopyricarb (= chlorodincarb), fenaminostrobin (= diclofenoxystrobin), flufenoxystrobin, 2-(2-(6-(3-chloro-2-methyl- phenoxy)-5-fluoro-pyrimidin-4-yloxy)-phenyl)-2-methoxyimino-N-methyl-acetamide, 3- methoxy-2-(2-(N-(4-methoxy-phenyl)-cyclopropane-carboximidoylsulfanylmethyl)-phenyl)- acrylic acid methyl ester, methyl (2-chloro-5-[1-(3- methylbenzyloxyimino)ethyl]benzyl)carbamate and 2-(2-(3-(2,6-dichlorophenyl)-1-methyl- allylideneaminooxymethyl)-phenyl)-2-methoxyimino-N methyl-acetamide; and 2) at least one herbicidal compound (II) selected from the group of imidazolinones con-sisting of imazamethabenz-methyl, imazamox, imazapic, imazapyr, imazaquin and imazethapyr; or an agriculturally acceptable salt thereof; and 3) a second herbicidal compound (III) selected from the group consisting of glyphosate and glufosinate; or an agriculturally acceptable salt thereof; in synergistically effective amounts. In addition, the invention relates to an agrochemical composition for increasing the health of a plant, comprising a liquid or sold carrier and a mixture as defined above. The present invention also relates to a method for synergistically increasing the health of a plant, which is tolerant to a herbicidal compound (III), wherein the plant, the locus where the plant is growing or is expected to grow or plant propagation material from which the plant grows is treated with an effective amount of a mixture as defined above. Furthermore, the present invention relates to the use of a mixture as defined above for synergistically increasing the yield of a plant wherein the treated plant is tolerant to a herbicidal compound (III).
Patent CA-2807158-A1 (CA)
Title: Treatment of diabetes with pancreatic endocrine precursor cells
Inventor: XU JEAN
IPC: A61K35/39
Filed: 2011-08-11
Abstract: The present invention provides a method for lowering blood glucose levels in an animal by transplanting a population of pancreatic endocrine precursor cells into an animal.