Patent SG-11201809931Y-A (SG)
Title: 2-anilinopyrimidine derivatives as therapeutic agents for treatment of brain cancers
Inventor: GRECO MICHAEL
IPC: C07D403/04
Filed: 2017-05-11
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111111111111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number 0 (43) International Publication Date .....0\"\" WO 2017/197062 Al 16 November 2017 (16.11.2017) WIPO I PCT — (51) (21) (22) (25) Filing Language: (26) (30) (71) (72) International Patent Classification: (74) Agent: LIU, Wansheng, Jerry et al.; Fox Rothschild A61K 31/506 (2006.01) C07D 403/04 (2006.01) LLP, 997 Lenox Drive, Building 3, Lawrenceville, NJ 08648-2311 (US). International Application Number: PCT/US2017/032066 (81) Designated States (unless otherwise indicated, for every International Filing Date: kind of national protection available): AE, AG, AL, AM, 11 May 2017 (11.05.2017) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, English DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, Publication Language: English HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, Priority Data: MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, 62/334,830 11 May 2016 (11.05.2016) US PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, Applicant: BETA PHARMA, INC. [US/US]; 1000 N. TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. West St., Suite 1200, Wilmington, DE 19801 (US). (84) Designated States (unless otherwise indicated, for every Inventors: GRECO, Michael, Nicholas; 1634 Clearbrook kind of regional protection available): ARIPO (BW, GH, Road, Lansdale, PA 19446 (US). COSTANZO, Michael, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, John; 14 Breckenridge Drive, Warminster, PA 18974 (US). UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, GREEN, Michael, Alan; 1184 Dewalt Drive, Easton, PA TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 18040 (US). PENG, Jirong; 11019 North Kensington Dr., EE, ES, FL FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Mequon, WI 53097 (US). WILDE, Victoria, Lynn; 50 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, Pine Street, Montclair, NJ 07042 (US). ZHANG, Don; 9 Kensington Court, Princeton, NJ 08540 (US). — = Title: 2-ANILINOPYRIMIDINE DERIVATIVES AS THERAPEUTIC AGENTS FOR TREATMENT OF BRAIN CANCERS Brain Bioiuminostence Sigrud Group compari tc with Std. Error , = (54) = = _ = — = = = = = = = = 0 10 1 2=4 RcE 3$ .Tii.rnor Mitil(I rit WU Figure 1. Brain Tumor BL1 Signal Group comparisons. : Methods of using substituted 2-anilinopyrimidine derivatives, and pharmaceutically acceptable salts, solvates, or corn- for the treatment of brain cancers, in particular EGFR-mediated metastatic brain cancer, are disclosed. © positions, 11 N V::+ © IN C:r 11 IN 1-1 (57) el C [Continued on next page] WO 2017/197062 Al MIDEDIMOMMIDIRMEMOMOIHEIMIHIMEDIMIE TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))