Patent EA-001978-B1 (EA)
Title: Container for a medical liquid
Inventor: KLADDERS HEINRICH
IPC: B65D83/14
Filed: 1999-02-26
Abstract: 1. A container for a medical liquid, which container is gas- and liquid-tight, characterised by: - a foil bag (11, 21, 31) which is closed at both ends and which is deformable at a differential pressure below 300 hPa (300 mbar), - a flange (15, 25, 34) which is stable in respect of shape and which is sealingly disposed on the foil bag and which is in the form of a releasable connecting element for fitting the container on to a discharge connection member (67), - at least one welded seam (13, 23, 32) with which the foil bag is closed at least one end and which extends substantially transversely with respect to the axis of the bag, - a sealing location (56, 64, 74) in the flange which is stable in respect of shape, - a discharge location for the liquid in the region of the flange which is stable in respect of shape. 2. A container according to claim 1 characterised by a fail bag which is deformable at a differential pressure below 150 hPa (150 mbar), preferably below 80 hPa (80 mbar). 3. A container according to claims 1 and 2 characterised by a foil bag (31) which is closed at both ends by a welded seam (32), and a flange (34) which is stable in respect of shape and which is sealingly mounted to the foil bag (31). 4. A container according to claims 1 and 2 characterised by a foil bag (11, 21) which is sealingly closed at one end by a welded seam (13, 23) and at the other end by the flange (12, 24) which is stable in respect of shape. 5. A container according to claims 1 to 4 characterised by a preferably rotatationally symmetrical flange (41, 51, 61) which is stable in respect of shape and the size of which is adapted to the size of the foil bag, and - with which the foil bag is closed at an end. 6. A container according to claims 1 to 5 characterised by a flange which is stable in respect of shape, with a guide passage (42, 54). 7. A container according to claims 1 to 6 characterised by a flange which is stable in respect of shape, with a press fit (55, 66, 77) within the guide passage. 8. A container according to claims 1 to 7 characterised by a flange which is stable in respect of shape and which comprises a thermoplastic material. 9. A container according to claims 1 to 8 characterised by a welded seam (91, 101) which is of a U-shaped or V-shaped configuration and which extends substantially transversely with respect to the axis of the bag and which extends partially in the direction of the axis of the bag, or a welded seam (III) which is of a T-shaped configuration. 10. A container according to claims 1 to 9 characterised by a sealing location in the form of a ring (64, 74) of elastic material, which is disposed in a groove. 11. A container according to claims 1 and 10 characterised by a discharge location which is in the form of a perforation location. 12. A container according to claims 1 to 11 characterised by a discharge location which is provided with a pierceable membrane. 13. A container according to claims 1 to 12 characterised by a discharge location which is provided with a pierceable membrane, wherein the membrane (43, 78) is disposed at the end of or within the guide passage, or the membrane (86) is a part of the foil bag. 14. A container according to claims 1 to 13 characterised by a discharge location which is sealed with a sealing foil (58, 84, 151). 15. A container according to claims 1 to 14 characterised by  - a foil bag comprising a foil of plastic material or metal or metal alloy, preferably aluminium, gold or copper, or - a foil bag comprising a composite foil of plastic material and metal, or - a foil bag comprising a plastic foil with a layer of metal, glass or ceramic. 16. A container according to claims 1 to 15 characterised by a foil bag with an inner foil of plastic material and an outer foil of metal, or two foils of different plastic materials. 17. A container according to claims 1 to 15 characterised by  - a foil bag with an inner foil comprising a copolymer, preferably a polyethylene copolymer of ethylene-acrylic acid, - a diffusion-tight central foil of metal or plastic material or a diffusion-tight central layer of metal, glass or ceramic, - an outer foil of plastic material whose melting temperature is higher than the melting temperature of the inner foil, preferably of polyethylene terephthalate. 18. A container according to claims 1 to 17 characterised by  - a foil bag comprising a plastic foil of a thickness of between 20 μm and 100 μm, or - a foil bag comprising a composite foil with an inner foil of plastic material of a thickness of between 20 μm and 100 μm and an outer foil of metal of a thickness of between 8 μm and 20 μm, or - a foil bag comprising a composite foil with an inner foil of plastic material of a thickness of between 20 μm and 100 μm, a central foil of metal of a thickness of between 8 μm and 20 μm and an outer foil of plastic material of a thickness of between 10 μm and 40 μm. 19. A container according to Claims 1 to 18 characterised by a filling volume of 0.5 millilitre to 5 millilitres, preferably from 1 ml to 4 ml. 20. A container according to claims 1 to 19 characterised by a filling volume of 1 ml to 3 ml or 2 ml to 4 ml. 21. A container according to claims 1 to 20 which is disposed in a casing (142) which is stable in respect of shape and which comprises metal or plastic material and which is connected to the flange. 22. A container according to claims 1 to 21 which is disposed in a casing which is stable in respect of shape, of a diameter of 10 mm to 30 mm, preferably 12 mm to 17 mm. 23. A container according to claims 1 to 22 which is disposed in a casing which is stable in respect of shape and from which the flange which is stable in respect of shape projects, wherein the length overall is from 20 mm to 60 mm, preferably 30 mm to 50 mm. 24. A container according to claims 1 to 23 characterised by a casing which is closed substantially all araound and which includes an opening or in which there is a gap at the location of connection to the flange, or a casing which is in the form of a basket with many openings, or a holder. 25. A container according to claims 1 to 24 which can be fitted into a discharge device which is provided with a connecting portion, characterised by a releasable, positively locking, push-in snap connection between the connecting portion (154; 161) in the discharge device and the flange (148), which is stable in respect of shape, of the container. 26. A container according to claim 25 characterised by a peripherally extending groove (158; 147) in the flange which is stable in respect of shape, into which the snap noses (156, 163) of the snap hooks (155; 162), which are provided on the connecting portion (154; 167) engage when the container is fitted into the connecting portion. 27. Use of the container according to claims 1 to 26 as a primary packaging for a medical liquid which is taken in many partial quantities from the foil bag. 28. Use of the container according to claims 1 to 27 as a primary packaging for a medical liquid which is taken portion-wise in a respective dosage of 10 microlitres to 50 microlitres, preferably 15 μl to 20 μl. 29. Use of the container according to claims 1 to 28 as a cartridge containing an inhalable medicament preparation in a propellant gas-free atomiser. 30. Use of the container according to claims 1 to 29 as a cartridge containing an inhalable medicament preparation which is present in the form of a solution in ethanol or in ethanol/water or in water. 31. Use of the container according to claims 1 to 30 as a cartridge containing an inhalable medicament preparation with an active substance or with a plurality of active substances such as berotec (fenoterol hydrobromide; 1-(3,5-dihydroxyphenyl)-2-[[1-(4-hydroxybenzyl)-ethyl]-amino]-ethanol-hydrobromide), atrovent (ipratropium bromide), berodual (combination of fenoterol hydrobromide and ipratropium bromide), salbutamol (or albuterol), combivent, oxivent (oxitropium bromide), Ba 679 (tiotropium bromide), BEA 2108 (di-(2-thienyl)-glycol acid tropenol ester), beclomethason, flunisolid and budesonid. 32. Use of the container according to claims 1 to 31 with a medicament preparation for the treatment of ailments by means of inhalable active substances.