baber/WOPTO huggingface dataset:
Patent JP-2021086717-A (JP)
Title: Electric storage device
Inventor: KANEMOTO MASAKI
IPC: H01M50/20
Filed: 2019-11-27
Abstract: To suppress damage of a heat welding unit caused by expansion of an electric storage element.SOLUTION: An electric storage device 1 includes an electric storage element 20 having a long side face 211 and a short side face 212, and having a container 21 for storing an electrode body therein, and an exterior body 10 for hermetically storing the electric storage element 20. The exterior body 10 includes a main body unit 11 (first member) having an opening 111 for storing the electric storage element 20 therein and an outer lid 12 (second member) to be joined to the main body unit 11 in a state of covering the opening 111. The main body unit 11 and the outer lid 12 have a heat welding unit 90 joined to each other along a whole periphery of the opening 111. The outer lid 12 has a convex unit 124 having a projecting region in a direction parallel to the long side face 211, extending along a whole periphery of the opening 111, and forming a part of the heat welding unit 90. The main body unit 11 has an inner wall unit 51 disposed inside the convex unit 124 and covering the heat welding unit 90 from an inside. The inner wall unit 51 is restricted from outside by the convex unit 124.SELECTED DRAWING: Figure 5
Patent JP-2021083356-A (JP)
Title: Rice
Inventor: KITAHARA DAISUKE
IPC: C12G3/02
Filed: 2019-11-27
Abstract: To provide a rice that makes it possible to produce sake with a more fragrant flavor.SOLUTION: In a rice according to this invention, Moromi (unrefined sake) is obtained by using rice with a milling rate of 80% or less as brewing rice and malted rice and through the 3-steps preparation under the conditions of a malted rice rate of 10% or more and a water rate of 120% to 140%. When the Moromi is fermented at a temperature of 15°C or lower, a Baume value in a fermentation step becomes the highest after four days from the preparation of the Moromi.SELECTED DRAWING: Figure 1
Patent JP-2021083397-A (JP)
Title: Automatic travel system
Inventor: WATANABE TOSHIKI
IPC: A01B69/00
Filed: 2019-11-29
Abstract: To provide an automatic travel system that makes threshing efficiency and travel efficiency easily become suitable.SOLUTION: An automatic travel system A for managing automatic travel of a combine 1 for performing reaping travel in a square unreaped area in a farm field comprises: a selection unit 4a for selecting one side of four sides constituting a contour line of the unreaped area; a determination unit 4b for determining whether or not an inclination with respect to the selection side, the side selected by the selection unit 4a, of a side opposite to the selection side is equal to or smaller than a predetermined reference angle; and a streak direction decision unit 4c for deciding a streak direction in the unreaped area. When it is determined by the determination unit 4b that the inclination is larger than the reference angle, the streak direction decision unit 4c decides as the streak direction a direction in which the selection side extends. When it is determined by the determination unit 4b that the inclination is equal to or smaller than the reference angle, the streak direction decision unit 4c decides as the streak direction either one of the direction in which the selection side extends and a direction in which the side opposite to the selection side extends, depending on a state of a machine body.SELECTED DRAWING: Figure 5
Patent JP-2021089563-A (JP)
Title: Electronic control device, control method, and sensor system
Inventor: KASAHARA NOZOMI
IPC: G06F1/10
Filed: 2019-12-04
Abstract: To prevent radiation noise.SOLUTION: There is provided an electronic control device to be connected by each of a plurality of sensors outputting sensor output for each of predetermined data obtainment cycles in accordance with clock signals, and also by a cable, comprising: a power source supply section for supplying the sensors with power over the cable; an obtainment section for obtaining a feature amount indicating a size of radiation noise from at least one sensor out of the plurality of sensors in a direct or indirect manner; a phase difference determination section for determining a phase difference of the data obtainment cycles for each of the plurality of sensors based on the feature amount; and a control section for communicating the phase difference to each of the plurality of sensors.SELECTED DRAWING: Figure 1
Patent JP-2021090027-A (JP)
Title: Abrasive composition
Inventor: NAGAKURA NAOTO
IPC: C09G1/02
Filed: 2019-12-06
Abstract: To provide an abrasive composition for crystal substrate of compound semiconductor and a polishing method therefor, capable of reducing metal pollution because of no metal dissolved in abrasive composition and achieving efficient and precise polishing.SOLUTION: The present invention comprises an abrasive composition containing hypohalous acid ion, organic cation, free metal and water, a polishing method for non-oxide single crystal substrate using the abrasive composition and a manufacturing method for non-oxide single crystal substrate polishing using the polishing method.SELECTED DRAWING: None
Patent JP-2021091157-A (JP)
Title: Belt-like member for rehabilitating existing pipe, and method and apparatus for manufacturing the same
Inventor: UEDA KAZUTAKA
IPC: B29C48/03
Filed: 2019-12-11
Abstract: To provide a belt-like member for rehabilitating an existing pipe capable of securing flowing capacity in normal times and reliably exhibiting seismic performance.SOLUTION: A belt-like member 10 for rehabilitating an existing pipe that includes a main belt portion 11 and a telescoping belt portion 12 that straddles an intermediate portion 11c of the main belt portion 11 is manufactured by a manufacturing apparatus 20. The belt-like member 10 is extrusion molded so that a weld line 15 is formed at the intermediate portion 11c of the main belt portion 11 by an extrusion molding unit 21 of the apparatus 20. Thereafter, the main belt portion 11 is cut at the weld line 15 by a cutting mechanism 33 to form a cut portion 16.SELECTED DRAWING: Figure 4
Patent JP-2021097255-A (JP)
Title: Information terminal device
Inventor: NAKANISHI YOSHIKATSU
IPC: H04M1/02
Filed: 2019-12-13
Abstract: To make a wristwatch-type information terminal device highly functional and/or multifunctional.SOLUTION: In a wristwatch-type information terminal device 1, due to deployment and usage of a film-shaped input/output unit 4 from a substrate 3, the information terminal device 1 is made compact while realizing high functionality and/or multifunctionality. Then, the back surface of the input/output unit 4 on a substantially half surface 43 side is supported by a support member 5, the support member 5 is slid sideways by a moving member 61 and dropped by links 631 and 632, and the substrate 3 and the support member 5 are made flush with each other. A remaining substantially half surface 44 of the input/output unit 4 is exposed by sliding sideways, and a shaft 46 of a base end 45 is shifted by a support piece 71 and turned over to be deployed. As a result, it is possible to realize a support structure that realizes a reliable input/output operation from the film-shaped input/output unit 4.SELECTED DRAWING: Figure 2
Patent JP-2021082235-A (JP)
Title: Intelligent type road condition display board for traffic
Inventor: CHEN YIKAI
IPC: G08G1/095
Filed: 2019-12-14
Abstract: To provide an intelligent type road condition display board for traffic, which can improve a congestion problem.SOLUTION: An intelligent type road condition display board for traffic has a monitoring post 12. A rain shield 11 is fixedly installed on a left wall of the monitoring post. A presentation board power space 100 is provided in the monitoring post. A presentation plate power device 101 is installed in the presentation plate power space. The presentation board power device provides power to the intelligent type road condition display board for traffic.EFFECT: Since the intelligent type road condition display board for traffic is convenient to use and to maintain and the intelligent type road condition display board for traffic monitors a road condition in a timely manner to send road information to a driver, the driver can make a decision in advance based on an estimated transit time displayed and avoid a congested area. The display board for traffic does not affect the traffic on the road ahead, saves the driver's time, and greatly improves traffic efficiency.SELECTED DRAWING: Figure 1
Patent JP-2021096925-A (JP)
Title: Vehicular lighting fixture
Inventor: IKENOUE SHO
IPC: H01L51/50
Filed: 2019-12-16
Abstract: To provide a vehicular lighting fixture that can be less likely to be subjected to shape restriction due to undercut or a punching degree.SOLUTION: A vehicular lighting fixture 10 includes: light sources 31, 32; a columnar first light guide body 41 being formed of a soft material and guiding light from the light sources 31, 32; a plate-like second light guide body 51 being adjacent to a first light-emitting surface 41C of the first light guide body 41, formed of a soft material and guiding light from the first light guide body 41; and multiple brackets 60, 70 being disposed while being separated from each other in a longitudinal direction N of the first light guide body 41 and connecting the first light guide body 41 to the second light guide body 51.SELECTED DRAWING: Figure 2
Patent JP-2021094755-A (JP)
Title: Liquid discharge head
Inventor: MORI TATSURO
IPC: B41J2/14
Filed: 2019-12-16
Abstract: To provide a liquid discharge head configured so that a flow passage member can be prevented from deforming.SOLUTION: The liquid discharge head comprises: an element substrate having a heating element for heating liquid in a pressure chamber; a first flow passage member in which individual supply flow passages for supplying liquid to the pressure chamber and individual collection flow passages for collecting the liquid from the pressure chamber are formed; and a second flow passage member 60 in which common supply flow passages 211 connected to the plurality of individual supply flow passages and a common collection flow passage 212 connected to the plurality of individual collection flow passages are formed. The common supply flow passages 211 and the common collection flow passage 212 are extended in a longitudinal direction of the second flow passage member 60 and are formed in parallel with each other in an arranging direction, which is a direction crossing the longitudinal direction. Either of the common supply flow passages 211 and the common collection flow passage 212 is arranged at a side closest to one end of the second flow passage member 60 and at a side closest to the other side thereof in the arranging direction.SELECTED DRAWING: Figure 6
Patent JP-2021093974-A (JP)
Title: Tea beverage
Inventor: IKEGAMI YUKIKO
IPC: A23L2/38
Filed: 2019-12-18
Abstract: To provide a tea beverage that maintains a clear taste and yet shows improvement in richness and thickness of the taste.SOLUTION: A tea beverage contains 4-ethylphenol with the 4-ethylphenol content of 8-100 ppb. The tea beverage may contain a grain extract. The tea beverage may also contain an extract from Hordeum vulgare and Coix lachryma-jobi var. ma-yuen.SELECTED DRAWING: None
Patent JP-2021100319-A (JP)
Title: Joining structure of two conductive members
Inventor: HINAMI KEIJI
IPC: H02G15/08
Filed: 2019-12-20
Abstract: To provide a structure in which flat surfaces of tip portions of two conductive members are easily brought into close contact with each other in a joining structure of the two conductive members.SOLUTION: In a joining structure disclosed in the present specification, flat surfaces of tip portions of two conductive members are joined together. A boundary between the tip portion of one of the conductive members and a main body is curved in an S-shape. By providing an S-shaped curved portion at a root of the tip portion, rigidity between the tip portion and the main body is reduced, and the flat surfaces easily come into close contact with each other. The conductive member having the S-shaped curved portion is suitable for use for joining with a terminal of a semiconductor module in which a semiconductor element is embedded.SELECTED DRAWING: Figure 1
Patent JP-2021099053-A (JP)
Title: Spark ignition engine
Inventor: ISOJIMA HIROAKI
IPC: F02P15/00
Filed: 2019-12-20
Abstract: To provide a spark ignition engine that is advantageous in cost and/or assembling man-hours by further devising a support structure for an ignition coil built-in type plug cap.SOLUTION: In a spark ignition engine, a cylindrical part 3t capable of supporting an ignition coil built-in type plug cap 18 is formed in a head cover 3 while being compatible with a plug hole 13 of a cylinder head 2. The cylindrical part 3t is configured such that a pipe material 22 is fitted and fixed to a mount hole part 3s formed in the head cover 3 while being facing the plug hole 13.SELECTED DRAWING: Figure 1
Patent JP-2021098673-A (JP)
Title: Oil-based cosmetics
Inventor: AIDA KENJI
IPC: A61Q1/06
Filed: 2019-12-23
Abstract: To provide oil-based cosmetics that exhibit extremely vivid coloring with an oil-soluble dye and sustain its vividness for a long time.SOLUTION: Oil-based cosmetics contain following components (A), (B) and (C): (A) 5-95 mass% of a polyglycerol fatty acid ester in which a polyglycerol with an average degree of polymerization of 4-15 calculated from a hydroxyl value is esterified with a C12-22 linear or branched fatty acid, (B) an oil-soluble dye, (C) an organic oil gelling agent 4.5-25 mass%. The mass ratio of the component (A) to the total amount of an oil phase including the component (A) ((A)/total oil phase amount) is 0.2-0.95.SELECTED DRAWING: None
Patent JP-2021100089-A (JP)
Title: Coil device
Inventor: KAKIZAKI KAZUKI
IPC: H01F41/04
Filed: 2019-12-24
Abstract: To provide a coil device that has sufficient strength, is easy to be transported, is easy to be handled, and has low DC resistance.SOLUTION: In an inductor element (coil device) 2, a coil conductor 6 includes a laminated portion 11a in which surfaces of a plurality of conductive plate pieces 6a1 and 6a2 are electrically connected to each other in a laminating direction. Therefore, an aspect ratio (cross-sectional thickness/cross-sectional width) of a cross section of the coil conductor 6 can be brought close to 1, and can be set to 1 or more in some cases.SELECTED DRAWING: Figure 2A
Patent JP-2021103742-A (JP)
Title: Organic electroluminescent device
Inventor: HATAKEYAMA TAKUJI
IPC: C09K11/06
Filed: 2019-12-25
Abstract: To provide an organic EL device having long device life and excellent quantum efficiency.SOLUTION: An organic electroluminescent device is provided which includes an anode, an organic layer, a light emitting layer, and a cathode in this order, wherein the light emitting layer includes a polycyclic aromatic compound or a multimer thereof, and the organic layer includes a specific compound.SELECTED DRAWING: None
Patent JP-2020058849-A (JP)
Title: Mouthpiece for infant feeding vessel
Inventor: MARIJN KESSELS
IPC: A61J11/04
Filed: 2019-12-26
Abstract: To provide a mouthpiece for an infant feeding vessel, and/or an infant feeding vessel including a mouthpiece.SOLUTION: A mouthpiece for an infant feeding vessel has a mounting collar 60 configured to be received between a receptacle 30 and a connector 40 for mounting a mouthpiece 20 on the receptacle when assembled. The mouthpiece also has an air valve in the mounting collar to allow a flow of air into the receptacle when the mouthpiece is mounted on the receptacle. The air valve is biased towards an open condition in its unassembled state. At least part of the mounting collar is resilient and is configured to be received between the receptacle and the connector when assembled. The mounting collar is deformable to act on the air valve to control the air valve towards a closed or further closed condition when the at least part of the mounting collar that is resilient is compressed between the receptacle and the connector and then urged to deform in an inwardly radial direction of the mounting collar.SELECTED DRAWING: Figure 1
Patent JP-2021106371-A (JP)
Title: Sound collector
Inventor: KAWACHI HIROTO
IPC: H04R1/08
Filed: 2019-12-27
Abstract: To provide a sound collector having a simple structure capable of collecting sounds without an influence of wind and rain, out of doors.SOLUTION: A sound collector 100 comprises: a tube 110 having an open first end 111 and a second end 112 covered with a support member 120; and a microphone 130 disposed on the support member 120 inside the tube 110. The support member 120 is provided with an open hole bored in a region in which the microphone 130 is not disposed.SELECTED DRAWING: Figure 2
Patent JP-2021107871-A (JP)
Title: Projection type image display system
Inventor: IBUKI SHUNTARO
IPC: G02B5/30
Filed: 2019-12-27
Abstract: To provide a projection type image display system that displays different images on both sides.SOLUTION: A projection type image display system comprises: a projection device that emits two types of linearly polarized light projection images; a light guide plate that has an incident surface on which the projection images emitted from the projection device are incident, and guides the light of the projection images incident from the incident surface; a first optical element that is arranged on a first principal surface of the light guide plate and emits one of the incident projection images from the light guide plate; and a second optical element that is arranged on a second principal surface of the light guide plate and emits the other of the incident projection images from the light guide plate. The rays of linearly polarized light forming the two types of projection images emitted from the projection device are orthogonal to each other. The first optical element and the second optical element each have a phase difference layer that indicates a phase difference by the λ/4 wavelength at an angle at which the projection image is incident on the optical element, and a circular polarization selective diffraction element in this order from the light guide plate side. The linearly polarized light reflected by the first optical element and the linearly polarized light reflected by the second optical element are orthogonal to each other.SELECTED DRAWING: Figure 1
Patent JP-2021099766-A (JP)
Title: Target-selective learning support platform, learning support device, and program
Inventor: SHINOHARA Tsubasa
IPC: G06Q50/20
Filed: 2019-12-23
Abstract: To solve the problem that in a learning support method in which a user learns using various terminals, the conventional provision of learning content divided only by each subject or unit has difficulty in seeing utilization scenes when going out to society and doing actual business and asking about relationship with life.SOLUTION: Any learning theme modeled on profession or contents to be implemented, and learning content classified based on knowledge and skills related to actual work and actual business are prepared. An interface or a content selection space is constructed by a profession theme axis modeled on the profession or contents to be implemented, and a learning classification axis classified by the knowledge and skills related to the actual work and actual business. The user selects any content arranged while seeing the profession theme axis and the learning classification axis, and can receive education.SELECTED DRAWING: Figure 1
Patent JP-2021099091-A (JP)
Title: Sheet wave power generation
Inventor: YOSHIDA HIROAKI
IPC: F03B13/14
Filed: 2019-12-20
Abstract: To provide a sheet wave power generation device that has excellent efficiency.SOLUTION: A sheet wave power generation device includes a sheet-like float which floats on the water and generates power with the force moving upward and downward.
Patent JP-2019527211-A (JP)
Title: 殺有害生物活性混合物
IPC: A01P7/04
Filed: 2017-07-06
Abstract: 本発明は、a)式(I)の化合物a)、b)式(1a)の化合物b)、c)化合物a)及びb)を含む混合物から選択される殺有害生物活性化合物I及び少なくとも1種のさらなる殺有害生物活性成分を含む殺有害生物混合物に関する。本発明はさらに、これらの混合物の、植物中及び植物上の昆虫、ダニ、又は線虫を駆除及び防除するための、並びにこのような植物が有害生物に寄生されることを保護するための方法及び使用に関する。【選択図】なし
Patent JP-2019528600-A (JP)
Title: クラウドソーシングおよび測位のための測定値についての地上ネットワークの同時スキャン
IPC: H04L7/00
Filed: 2017-06-28
Abstract: モバイルデバイスは、測位測定値について異なる地上ネットワークを同時にスキャンして、スキャンを時間整合する。スキャン間の最小の時間差を用いて、異なる地上ネットワークからの測位測定値は、クラウドソーシングまたは位置決定のために使用され得る。モバイルデバイスは、ワイヤレスワイドエリアネットワーク（ＷＷＡＮ）およびローカルエリアワイヤレスネットワークを同時にスキャンし得、その結果、スキャンから導出された測位測定値が時間整合される。ローカルエリアワイヤレスネットワークは、例えばワイヤレスローカルエリアネットワーク（ＷＬＡＮ）またはワイヤレスパーソナルエリアネットワーク（ＷＰＡＮ）であるが、セルラネットワークも衛星ネットワークも含まない。スキャンは、スキャン間のほぼゼロの時間差を用いた厳しい同期を確実にするためにハードウェアレベルでスケジューリングされ得る。代替的に、スキャンはソフトウェアレベルで同期され得、互いからの時間差しきい値内で生じるスキャンのみがクラウドソーシングまたは測位のために使用される。
Patent JP-2019525857-A (JP)
Title: グリーンシートセラミック上へのメタライゼーション材料の、サブミクロン均一性を有する高精度スクリーン印刷
IPC: B41F15/08
Filed: 2017-08-04
Abstract: グリーンシートセラミック上に印刷されるメタライゼーション材料のサブミクロン均一性が可能である高精度スクリーン印刷が、記載されている。いくつかの例では、金属を含有するペーストを、電気トレースのパターンでセラミックグリーンシート上にスクリーン印刷し、印刷されたグリーンシートを処理してワークピースキャリアのパックを形成することによって、電気トレースを有するパックが、形成される。いくつかの例では、印刷することは、グリーンシートがスクリーンプリンタのプリンタ台上にある間に、スクリーンプリンタのスキージを、印刷されているグリーンシートにスキージ方向に当てることを、含む。この方法はさらに、スキージ方向に沿った複数の位置でプリンタ台をマッピングすること、プリンタ台マッピング内の不均一性を識別すること、およびスクリーンプリンタのプリンタコントローラを修正して、プリンタ台におけるマッピングされた不均一性を補償することを含む。【選択図】図４
Patent JP-2019514638-A (JP)
Title: マーカを設けられた機械的導波管
IPC: A61B17/22
Filed: 2017-04-25
Abstract: 機械的波動を伝達するための装置であって、細長い形状を有し、近位端において結合される機械的波動を遠位端まで伝搬するために近位端と遠位端との間に延在する機械的導波管と、機械的波動に対して機械的導波管の遠位端に隣接して固定される放射線不透過性マーカとを備える、装置が説明される。
Patent JP-2019528626-A (JP)
Title: スピーカーを組み込んだヘッド支持体および多次元音響効果を再生するためのシステム
IPC: H04R5/027
Filed: 2017-08-18
Abstract: 音声再生のための装置（１００）は、変形可能な材料で作られた、ユーザの頭部（５０）用の静止要素（１０）を含み、右横方向支持エレメント（２０）および左横方向支持エレメント（３０）は、それぞれ静止要素（１０）の左右２つの側（１１、１２）に配置され、右横方向支持エレメント（２０）および左横方向支持エレメント（３０）は、静止要素（１０）によって互いに接続されており、右横方向支持エレメント（２０）および左横方向支持エレメント（３０）は、リスニング空間と横方向支持エレメントに平行な長手方向を互いに画定し、右横方向支持エレメント（２０）および左横方向支持エレメント（３０）にそれぞれ取り付けられた右スピーカー（２１）および左スピーカー（３１）は、右横方向支持エレメントと左横方向支持エレメントの間に画定されるリスニング空間（８０）に面するそれぞれの放音面（２２、３２）を有する。静止要素（１０）は、左右の耳（５２、５３）を有するユーザを右スピーカーおよび左スピーカー（２１、３１）に向けて配置するように構成された、頭部（５０）の一部（５１）のためのハウジング（１３）を提供し、左右の耳（５２、５３）はリスニング軸（５４）を形成する。スピーカー（２１、３１）はそれぞれウーファー（２３、３３）とツイーター（２４、３４）を有し、ツイーター（２４、３４）は、実質的にゼロに等しい第１の仰角値（α）の間でリスニング軸（５４）に対して所定の仰角（α）を向く対称軸（６０）を有し、ツイーター（２４、３４）は、互いに一直線上にあり、リスニング軸（５４）と平行な対称軸（６０）と、４５度に実質的に等しい第２の仰角値（α）を有し、ツイーター（２４、３４）は、リスニング軸よりも高い位置にある点に向かって収束する対称軸を有する。バイノーラル録音のシステムおよび多次元効果を再生するためのシステムも含まれる。【選択図】図１
Patent JP-2019530304-A (JP)
Title: ミリ波通信におけるマルチアンテナワイヤレス通信システムのための自己較正および送信遮蔽検出をユーザ機器において可能にするためのシグナリング機構
IPC: H04W88/02
Filed: 2017-08-28
Abstract: 低干渉環境においてローカル動作を実行することが可能な装置が望まれる。ある態様では、装置はユーザ機器(UE)であり得る。UEはローカル動作通知を基地局に送信し、ローカル動作通知はUEにとってローカルであるローカル動作を示す。UEは、基地局から、ローカル動作に利用可能な1つまたは複数のリソースを示すリソースインジケータを受信する。UEは、1つまたは複数のリソースを使用してローカル動作を実行する。
Patent JP-2019528306-A (JP)
Title: グルカゴン受容体シグナル伝達の干渉による重度のインスリン抵抗性の処置方法
IPC: A61K31/4439
Filed: 2017-08-29
Abstract: 本明細書では、重度のインスリン抵抗性を有する患者を処置する方法が提供される。方法は、それを必要とする患者に治療量のＧＣＧ／ＧＣＧＲシグナル伝達経路阻害剤を投与することを含み、これにより、血中グルコースもしくはベータ−ヒドロキシブチレートレベルが低下するか、または重度のインスリン抵抗性が媒介されるか、または重度のインスリン抵抗性によって特徴付けられる状態もしくは疾患が媒介されるか、または状態もしくは疾患と関連付けられる少なくとも１つの症状もしくは合併症が緩和されるか、もしくはその重症度が低減する。ＧＣＧ／ＧＣＧＲシグナル伝達経路阻害剤は、シグナル伝達経路の小分子阻害剤、シグナル伝達経路のアンチセンス阻害剤、ＧＣＧ中和モノクローナル抗体、ＧＣＧＲアンタゴニスト、シグナル伝達経路のペプチド阻害剤、ＤＡＲＰｉｎ、Ｓｐｉｅｇｅｌｍｅｒ、アプタマー、操作されたＦｎ ＩＩＩ型ドメインなどであってよい。【選択図】図１Ａ
Patent JP-2019530441-A (JP)
Title: Ｉｃａｍ−１に特異的なｉドメインキメラ抗原受容体
IPC: C12N5/10
Filed: 2017-08-11
Abstract: 本発明は、ヒトリンパ球機能関連抗原１（ＬＦＡ−１）のａＬサブユニットのＩドメインを含む細胞間接着分子１（ＩＣＡＭ−１）に特異的なキメラ抗原受容体（ＣＡＲ）に関する。本発明は特に、ＩＣＡＭ−１に対して異なる親和性（１ｍＭ〜１ｎＭのＫｄ）を有するヒトＩドメインを含むＣＡＲに関する。ＩＣＡＭ−１に対して低い親和性（１〜２００μＭのＫｄ）を有するヒトＩドメインを含むＣＡＲ−Ｔ細胞は、高いＩＣＡＭ−１発現を有する腫瘍組織に対して増強された効能および長期の有効性を示し、同時に、基線レベルのＩＣＡＭ−１発現を有する健常組織を標的とすることを回避することができる。本発明は、ヒトＩドメインを含むＣＡＲ−Ｔ細胞を癌に罹患している対象へ投与することにより、ＣＡＲ−Ｔ細胞がＩＣＡＭ−１を過剰発現する癌細胞に結合して癌細胞を死滅させることで癌を治療する、養子細胞療法の方法にも関する。【選択図】図１Ｄ