Patent SG-11201805137X-A (SG)
Title: Virus encoding an anti-tcr-complex antibody or fragment
Inventor: BROWN ALICE CLAIRE NOEL
IPC: A61K35/761
Filed: 2016-12-19
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 22 June 2017 (22.06.2017) WIPO I PCT (10) International Publication Number WO 2017/103291 Al 111111111111110111011111111111010111110 01011111011101111111 011111111111110111111 (51) International Patent Classification: A61K 35/761 (2015.01) C07K 16/28 (2006.01) A61K 35/768 (2015.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/EP2016/081818 (22) International Filing Date: 19 December 2016 (19.12.2016) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1522334.0 17 December 2015 (17.12.2015) GB 1607463.5 29 April 2016 (29.04.2016) GB 1617207.4 10 October 2016 (10.10.2016) GB 1617206.6 10 October 2016 (10.10.2016) GB (71) Applicant: PSIOXUS THERAPEUTICS LIMITED [GB/GB]; 154B Milton Park, Abingdon Oxfordshire OX14 4SD (GB). (72) Inventors: BROWN, Alice Claire Noel; 154B Brook Drive, Milton Park, Abingdon Oxfordshire OX14 4SD (GB). CHAMPION, Brian Robert; 154B Brook Drive, Milton Park, Abingdon Oxfordshire OX14 4SD (GB). (74) Agents: STERLING IP et al.; Orion House, Bessemer Road, Welwyn Garden City Hertfordshire AL7 1HH (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) W O 20 17 / 103 29 1 Al (54) Title: VIRUS ENCODING AN ANTI-TCR-COMPLEX ANTIBODY OR FRAGMENT (57) : The present disclosure relates to a replication deficient oncolytic viral vector or replication capable oncolytic virus encoding an antibody or a binding fragment thereof to the antigen-specific T-cell receptor complex (TCR) for expression on the sur- face of a cancer cell, pharmaceutical compositions comprising the same, and use of any one of the same in treatment, particularly in the treatment of cancer.