baber/WOPTO huggingface dataset:
Patent CA-2457952-C (CA)
Title: Substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 7-pyrimidinyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1h) one derivatives for neurodegenerative disorders
Inventor: SAADY MOURAD
IPC: C07D239/00
Filed: 2002-09-19
Granted: 2009-11-10
Abstract: The invention relates to a pyrimidone derivative represented by formula (I) or a salt thereof wherein: X represents two hydrogen atoms, a sulphur atom, an oxygen atom or a C1-2 alkyl group and a hydrogen atom; y represents a bond, an ethenylene group, an ethynylene group, an oxygen atom, a sulphur atom, a sulfonyl group, a sulfoxide group, a carbonyl group, a nitrogen atom being optionally; or a methylene group optionally substituted; R1 represents a pyrimidine group optionally substituted; R2 may represent a C1-6 alkyl group optionally substituted by a C6,10 aryloxy or a C6,10 arylamino group; a C3-6 cycloalkyl group, a C1-4 alkylthio group, a C1-4 alkoxy group, a C1-2 perhalogenated alkyl group, a C1-3 halogenated alkyl group, a phenylthio group, a benzyl group, a benzene ring, an indan ring, a 5,6,7,8- tetrahydronaphthalene ring, a naphthalene ring, a pyridine ring, a pyrrole ring, a thiophene ring, a furan ring or an imidazole ring; R3 and R4 represents each independently a hydrogen atom, C1-6 alkyl group, a hydroxy group, a C1-4 alkoxy group or a halogen atom; R5 represents a hydrogen atom, a C1-6 alkyl group or a halogen atom. The invention relates also to a medicame nt comprising the said derivative or a salt thereof as an active ingredient whi ch is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3.beta.3 or GSK3.beta.3 and cdk5/p25, such as Alzheimer disease.
Patent CA-2459575-C (CA)
Title: Client server networks
Inventor: MARTIN STEPHEN IAN
IPC: H04L29/08
Filed: 2002-09-18
Granted: 2012-07-24
Abstract: A client node in a network communicates with a server system comprising a plurality of servers. The client comprises a distributor which periodically measures server activity, assesses relative loading of the servers and adjusts the request distribution, and therefore the server loadings in accordance with the loading assessment.
Patent CA-2460628-C (CA)
Inventor: NEWTON RONALD O
IPC: B60T13/68
Filed: 1997-09-12
Granted: 2005-04-26
Abstract: A modular locomotive brake control unit having a manifold with electropneumatic modules each including electropneumatic and pneumatic elements removably mounted thereon each as a unit from the manifold. An electropneumatic equalization reservoir module controls the pressure at the equalization port. A brake pipe module controls brake pipe port pressure in response to the equalization reservoir port. An electropneumatic independent brake module controls pressure at the independent brake port as a locomotive brake signal. An electropneumatic brake signal module provides a pneumatic train brake signal. A controller controls the electropneumatic modules. Each electropneumatic unit includes an electropneumatic supply valve and an electropneumatic exhaust valve and preferably an electropneumatic valve having a first input connected to the supply and exhaust valves. The electropneumatic modules include a common block having a first interface with the manifold and including the electropneumatic valve as to supply and exhaust valves and includes an auxiliary block mounted to the common block having module specific pneumatic and electrical elements mounted on the auxiliary block.
Patent CA-2462697-C (CA)
Title: Procede et systeme de transmission efficace et fiable de paquets de donnees
Inventor: REZAIIFAR RAMIN
IPC: H04W28/04
Filed: 2002-10-02
Granted: 2013-02-05
Abstract: L'invention concerne un procédé et un système qui, en évitant la transmission de sous-paquets de données inutiles, permet un débit de données efficace tout en assurant le traitement des nouveaux paquets de données. Ces procédé et système différencient un sous-paquet pour un paquet de données actuel d'un sous-paquet pour un nouveau paquet de données en attribuant à chacun un code différent. Lorsqu'un sous-paquet présentement reçu et un sous-paquet précédemment reçu pour un paquet de données précédemment décodé ont les mêmes codes, la station distante envoie (506) un signal d'accusé de réception à la station de base pour empêcher la transmission de sous-paquets inutiles. Lorsque le sous-paquet présentement reçu et le sous-paquet précédemment reçu ont des codes différents, la station distante envoie (510) un signal d'accusé de réception si elle réussit à décoder le nouveau paquet du sous-paquet actuel. Sinon, la station distante envoie (516) un signal d'accusé de réception négatif à la station de base et demande davantage de sous-paquets pour le paquet actuel si la limite préétablie du nombre de transmissions relatives au sous-paquet présentement reçu n'est pas atteinte.
Patent CA-2465835-C (CA)
Inventor: STEVENSON MICHAEL J
IPC: B29C37/00
Filed: 2002-11-29
Granted: 2011-07-05
Abstract: A mixture of a carrier and binder component and polymer powders is provided as a molding composition for sealing rotational molds or for reinforcing selected areas of rotationally molded parts. The carrier and binder component can be very low density polyethylene, petroleum jelly, hydrocarbon wax, hydrocarbon tackifier, or mixtures thereof, and the polymer powders are thermoplastics having a low melt index. The molding composition is applied to selected areas of the rotational mold, such as to the mating flanges of the mold halves to seal the parting line of the mold, or to areas within the mold where it is desired to have reinforced regions of greater wall thickness, such as ribs or bosses.
Patent CA-2466531-C (CA)
Inventor: WINTER REINHARD
IPC: C08G18/30
Filed: 2002-11-27
Granted: 2008-05-13
Abstract: The invention relates to a coated granular material, wherein the coating is a resin, comprising the reaction producing of at least one compound selected from the group consisting of cardol, cardanol or derivatives or oligomers of these compounds with an isocyanate component, and to a method for the preparation thereof. Water-soluble granular materials are suitable as substances to be coated. Examples of granular substances are fertilizers, crop protection agents, insecticides, pesticides, fungicides, drying agents and mixtures thereof. The substance coated according to the invention has advantageous properties since the resin can be applied in a selective and economical manner to the substrates due to its low tackiness. In particular, coated fertilizer granulates are advantageous in that, with regard to the applied amount of fertilizer, they can provide more nutrients to the plant. In addition, fertilizers can be provided that can provide nutrients to the plant over a longer period of time and continuously and they have an exact and reproducible release behavior according to the type of plant to be treated. Furthermore, the polyol component of the coating can be obtained from the renewable raw material cashew nut oil.
Patent CA-2467025-C (CA)
Title: Procede et appareil destines au traitement des eaux usees
Inventor: BOYD STEVEN H
IPC: C02F3/34
Filed: 2002-12-12
Granted: 2014-05-27
Abstract: L'invention concerne des systèmes de traitement d'eaux renfermant des contaminants non désirés. Des déchets produits dans les toilettes (1) et un générateur d'eaux usées (2) entrent dans un décanteur (3) et, après un certain temps, dans un bassin de répartition (4), aux fins de répartition vers un champs de percolation (5). Un appareil (31) est mis en oeuvre pour ajouter des microbes de culture, des éléments nutritifs comprenant des sources de carbone, ainsi que de l'oxygène après le passage dans le décanteur mais avant celui dans le bassin de répartition.
Patent CA-2468870-C (CA)
Inventor: MINICK CHRIS A
IPC: B24D3/28
Filed: 2002-11-04
Granted: 2010-06-29
Abstract: L'invention concerne un produit abrasif flexible doté d'un substrat flexible sous forme de feuille qui comprend de nombreux corps souples séparés les uns des aux autres et réunis dans un réseau généralement planaire formant un motif qui ménage des espaces ouverts entre les corps réunis adjacents, chacun de ces corps présentant une première surface et une seconde surface opposée. Ce substrat comporte par ailleurs des particules abrasives qui confèrent une surface abrasive à au moins la première surface. L'invention concerne par ailleurs un procédé de fabrication du produit abrasif qui consiste à fournir le substrat et à doter au moins sa première surface de particules abrasives pour obtenir une surface abrasive.
Patent CA-2469458-C (CA)
Title: Low molecular weight heparin assay, system and reagent therefor
Inventor: MIZE PATRICK D
IPC: C12Q1/56
Filed: 2002-12-09
Granted: 2011-02-01
Abstract: A method, kit, system and reagent for measuring low molecular weight heparin in a whole blood sample is provided which involves the use of a Factor Xa activator, such as Russell's Viper Venom, as the coagulation assay initiator.
Patent CA-2470173-C (CA)
Title: Mobile system for seismic emission with fixed coupling devices, and method therefor
Inventor: MEYNIER PATRICK
IPC: G01V1/047
Filed: 2002-12-12
Granted: 2014-09-23
Abstract: The invention concerns a system for seismic emission in an underground formation using at least a seismic source successively mobile in a plurality of prepared activating sites and a method therefor. The system comprises for example a plurality of coupling devices (1) including each for example two anchoring elements (12, 9') closely coupled with the terrain (by cementing for example). Said anchoring elements are integral with the seismic source (V), such as any particular type of vibrator or a pulse source, through transmission elements (10, 13). The seismic source is coupled with the coupling device (1) by fast locking means (18, 19). The coupling devices (1) may be pre-installed in a plurality of prepared sites above the monitored formation. Seismic monitoring operations can be carried out by successively moving at least a seismic source to the different sites of the installed coupling devices (1). The invention is in particular useful for equipping a mining zone of an underground area with periodical seismic monitoring means.
Patent CA-2472110-C (CA)
Inventor: RIGHT ROBERT
IPC: G01P5/12
Filed: 2004-06-22
Granted: 2008-06-03
Abstract: A device for monitoring changes in airflow rates through detector dust filters in addition to assessing air for alarm indicators, including smoke, heat, gas, and relative humidity, is provided. A method monitors airflow through the detection device and provides a maintenance indication when the airflow has been reduced due to contamination of the dust filters..
Patent CA-2478099-C (CA)
Title: Inhibiteurs
Inventor: EVANS DAVID MICHAEL
IPC: A61P11/00
Filed: 2003-03-04
Granted: 2011-10-04
Abstract: L'invention concerne des composés de formule générale (1) ou un sel pharmaceutiquement acceptable de ces composés. Dans cette formule, R?1¿ est sélectionné entre H, un alkyle inférieur, R?4¿-CO, R?4¿-O¿2?CCH¿2?, R?5¿-OCO et R?5¿-SO¿2? ; R?2¿ est sélectionné entre un alkyle inférieur, un cycloalkyle éventuellement substitué par un alkyle ou un groupe alkyloxy, un cycloalkylalkyle en (C¿5?-C¿12?) éventuellement substitué par un alkyle ou un groupe alkyloxy, un aralkyle éventuellement substitué par jusqu'à trois groupes sélectionnés entre F, Cl, Br, I, OH, un alkyle inférieur, O-(alkyle inférieur), O-benzyle, NH¿2?, NO¿2?, NH-acyle, CN et CF¿3?, et un aralkyloxyméthyle éventuellement substitué par jusqu'à trois groupes sélectionnés entre F, Cl, Br, OH, un alkyle inférieur et O-(alkyle inférieur) ; ou R?1¿ et R?2¿ forment un groupe o-xylylène éventuellement substitué sur le noyau aromatique par un groupe sélectionné entre F, Cl, Br, OH, un alkyle inférieur et O-(alkyle inférieur) ; R?3¿ est sélectionné entre H, OH et O-alkyle inférieur ; R?4¿ est sélectionné entre H, un phényle et un alkyle inférieur et R?5¿ est sélectionné ente un benzyle, un phényle et un alkyle inférieur. Ces composants peuvent servir de compositions pharmaceutiques.
Patent CA-2479720-C (CA)
Inventor: BOURGAULT CLAUDE
IPC: E02D27/35
Filed: 2004-08-26
Granted: 2007-03-13
Abstract: A method of circulating fluid to adjust a temperature of a material comprises providing a pressurized fluid source operative to adjust the temperature of a fluid and to push the fluid out through a supply port at a supply temperature and draw fluid in through a return port at a return temperature. A conduit is arranged in proximity to the material and the fluid is circulated through the conduit in alternating forward and reverse directions. An apparatus is provided for periodically reversing the direction of fluid flow through the conduit.
Patent CA-2482000-C (CA)
Inventor: LUCE DAVID A
IPC: A61B3/16
Filed: 2003-04-11
Granted: 2008-06-17
Abstract: An apparatus (14) for calibrating a non-contact tonometer (12) includes an electronic eye (24) having a damped pressure sensor (60) for receiving a tonometer air pulse and providing a pressure signal in response to the air pulse, and applanation simulation means (70) connected to the pressure sensor for providing a pseudo-applanation event when the pressure signal reaches a predetermined level corresponding to a known IOP measurement standard. A method for calibrating a non-contact tonometer using the inventive calibration apparatus is also described.
Patent CA-2493940-C (CA)
Title: Broadspectrum substituted oxindole sulfonamide hiv protease inhibitors
Inventor: TAHRI ABDELLAH
IPC: C07D209/34
Filed: 2003-08-14
Granted: 2011-11-22
Abstract: The present invention concerns the compounds having the formula (I) N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are H, optionally substituted C 1-6alkyl, C2-6alkenyl, C3-7cycloalkyl, aryl, Het1, Het2; R1 may also be a radical of formula (R11aR11b)NC(R10a R10b)CR9-; t is 0, 1 or 2; R2 is H or C1-6alkyl; L is -C(=O)-, -O-C(=O)-, -NR8-C(=O)-, -O-C1-6 alkanediyl-C(=O)-, -NR8-C1-6alkanediyl-C(=O)-, -S(=O)2-, -O-S(=O)2-, -NR8-S(=0)2 ; R3 is C1-6alkyl, aryl, C3-7 cycloalkyl, C3-7cycloalkylC1-4 alkyl, or arylC1-4alkyl; R4 is H, C1-4alkylOC(=O), carboxyl, aminoC(=O), mono- or di(C1-4alkyl)aminoC(=O), C3-7cycloalkyl, C2-6alkenyl, C2-6alkynyl or optionally substituted C1-6alkyl; formula (II) is formula (III) or formula (IV) ; R5a and R5b is C2-6alkenyl, C2-6 alkynyl, C3-7cycloalkyl or C1-6alkyl, optionally substituted on one or more atoms; R5a and R5b may also be hydrogen, aryl, Het1, Het2; R6 is hydrogen or C1-6alkyl optionally substituted on one ore more carbon atoms. It further relates to their use as broadspectrum HIV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. It also concerns combinations thereof with another anti-retroviral agent, and to their use in assays as reference compounds or as reagents.
Patent CA-2497385-C (CA)
Title: Apparatus for training a dog to heel
Inventor: BURTON SHELLEY
IPC: A01K27/00
Filed: 2005-02-16
Granted: 2009-09-29
Abstract: An apparatus for training a dog to heel includes an elongated body adapted to be vertically positioned against an outside portion of a leg of a dog trainer. The body has a top end and a bottom end. The top end is adapted for positioning against the leg in the vicinity of the upper thigh of the dog trainer. The bottom end is adapted for positioning against the leg in the vicinity of a lower calf of the dog trainer. Straps are provided at intervals along the body. The straps are adapted for strapping the body to the leg of the dog trainer. More than one training strap coupling is positioned at spaced vertical intervals along the body. The dog trainer connects a short training strap extending to a collar of a dog being trained at a selected training strap coupling at a height of the collar of the dog.
Patent CA-2511530-C (CA)
Inventor: GOLDBERG MICHAEL
IPC: A61K/
Filed: 2004-01-06
Granted: 2013-07-09
Abstract: A method for protection of a mammal that has impaired glucose tolerance or early stage diabetes mellitus from developing overt or insulin dependent diabetes comprises administering an orally effective dose of a pharmaceutical formulation comprising insulin at nighttime, e.g., at or shortly before bedtime.
Patent CA-2515549-C (CA)
Title: Steam distributor for steam showers
Inventor: JONES GEOFFREY ARTHUR
IPC: D21F7/00
Filed: 2004-02-06
Granted: 2010-05-18
Abstract: A steam distributor (1) that uses a porous metal plate to replace the conventional screen plate (3) of a steam shower for distributing steam to a moving web (2) such as the web of a paper making machine. Steam showers using a steam distributor with this porous metal plate can deliver extremely uniform steam to the surface of a paper web. Profiling steam showers constructed by using an array of the steam distributors are able to deliver the best profiling results for various paper products. The porous metal plate can be considered as an equivalent of a screen plate with thousands of micro-orifices arranged tightly in both the machine direction and the CD direction.
Patent CA-2516863-C (CA)
Title: Poloxamer emulsion preparations
Inventor: JORSAL STEEN BOYE
IPC: C09K23/42
Filed: 2004-02-20
Granted: 2011-12-06
Abstract: An emulsion composition comprising: an aqueous component, a non-ionic block copolymer, and an oil wherein the copolymer comprises at least 10% by weight of the composition.
Patent CA-2516898-C (CA)
Title: Process for the production of alkylaromatics
Inventor: POHL STEPHEN L
IPC: C07C2/66
Filed: 2004-02-25
Granted: 2011-10-11
Abstract: A process for producing an alkylaromatic compound includes contacting a dilute olefin feed with a lean oil stream containing aromatic compound and alkylaromatic compound in an absorption zone to provide an alkylation reaction stream containing aromatic compound, alkylaromatic compound and olefin. The alkylation reaction stream is reacted under alkylation reaction conditions in an alkylation reaction zone to provide an effluent containing the aromatic compound and alkylaromatic compound. The effluent of step is separated into the Jean oil stream which is recycled to the absorption zone and a product portion from which an alkylaromatic product is recovered.
Patent CA-2517930-C (CA)
Title: Pyridylsulfonamido pyrimidines for treating diabetic nephropathy
Inventor: MANN JESSICA
IPC: A61K31/505
Filed: 2004-03-03
Granted: 2011-04-26
Abstract: The present invention relates to the use of a compound of formula (I) wherein R1 is pyridyl or thiazolyl, any of which may optionally be substituted with C1-8alkyl or C2-8alkenyl; and a) R2 is methoxy and n is zero or one; or b) R2 is chlorine and n is zero and pharmaceutically acceptable salts thereof for lowering or controlling proteinuria, in particular for the treatment of diabetic nephropathy.
Patent CA-2522769-C (CA)
Title: Decal organization tool
Inventor: HANSEN ROGER A
IPC: B41M3/12
Filed: 1996-10-24
Granted: 2010-12-07
Abstract: A decal organization tool for products needing large numbers of decals utilizes a single large sheet on which all product decals for a specific product or product model are carried. The invention includes a means by which the previously unavoidable irregular margins surrounding the decals are effectively hidden from the eye and allows large sheet printing of decals with an aesthetically satisfactory overall appearance. An irregularly zone is added to the edge of each decal, and along with an ultraviolet responsive additive placed in the decal adhesive, allows the decal to form an indelible footprint on the product to which it is applied. The footprint, invisible to the eye, becomes visible under ultraviolet light, allowing identification of a specific decal and proof of its application to a product, even when the decal is no longer on the product.
Patent CA-2527409-C (CA)
Inventor: SOLBERG BRUCE JEROME
IPC: B65H23/24
Filed: 2004-06-11
Granted: 2011-01-25
Abstract: An apparatus and method for unwinding a roll (10) of web material (11) are disclosed herein. The web material (12) is unwound from the roll (10) and the machine direction of motion of the web is altered without creating a problematic span of web material. A value analogous to the tension of the web material is determined. The speed of the web is adjusted according to the analog of the tension of the web. The apparatus can comprise an unwind stand (100) to rotate the roll, and a means for altering the direction of travel of the web material. The apparatus further comprises a means to determine an analog of the web material tension and a means of controlling the speed of the web according to the analog of the web tension. The web material is routed to a downstream process.
Patent CA-2527922-C (CA)
Inventor: NEWBROUGH JERRY W
IPC: A61J1/00
Filed: 2004-05-20
Granted: 2011-08-16
Abstract: A reconstitution device is disclosed and includes a first container receiver having a first component cannula disposed therein, the first component cannula having a withdrawal port and a first transfer port formed thereon, a second container receiver having a second component cannula disposed thereon, the second component cannula having a vent port and a second transfer port formed thereon, a device body coupling the first container receiver to the second container receiver and having a transfer lumen formed therein, the transfer lumen in fluid communication with the first and second transfer ports, a selectively sealing interface secured to the device body and in fluid communication with the withdrawal port, and a venting member in communication with the vent port through a vent lumen.
Patent CA-2532711-C (CA)
Title: Revetement de particules polymeres poreuses a surface fonctionnalisee qui contiennent des cristaux superparamagnetiques avec monomeres polyisocyanates/diols ou epoxides
Inventor: FONNUM GEIR
IPC: C08F220/32
Filed: 2004-04-28
Granted: 2013-07-23
Abstract: L'invention concerne un procédé pour préparer des particules polymères enrobées contenant des cristaux superparamagnétiques. Le procédé selon l'invention consiste à : faire réagir des particules polymères poreuses à surface fonctionnalisée qui contiennent des cristaux superparamagnétiques et dont le diamètre est compris 0,5 et 1,8 ?m avec au moins un polyisocyanate et au moins un diol ou au moins un époxyde.
Patent CA-2534060-C (CA)
Title: Hepatitis virus core proteins as vaccine platforms and methods of use thereof
Inventor: MILICH DAVID R
IPC: A61K/
Filed: 2004-07-19
Granted: 2012-06-12
Abstract: The present invention relates to hepatitis virus core proteins and nucleic acids. In particular, the present invention provides compositions and methods comprising recombinant hepatitis virus core proteins or nucleic acids for use in vaccine formulations.