baber/WOPTO huggingface dataset:
Patent WO-2020113753-A1 (WO)
Title: Oled pixel driving circuit and display panel
Inventor: CHEN CAIQIN
IPC: G09G3/3208
Filed: 2019-01-03
Abstract: An OLED pixel driving circuit and a display panel. The OLED pixel driving circuit forms a 7T1C type pixel driving circuit by means of a first transistor, a second transistor, a third transistor, a fourth transistor, a fifth transistor, a sixth transistor, a seventh transistor, a capacitor, and an organic light emitting diode. The first transistor, the second transistor, the third transistor, the fourth transistor, the fifth transistor, the sixth transistor, and the seventh transistor each have a control end, and a first end, and a second end. The control end of the seventh transistor is coupled to the second end, the control end of the fourth transistor is coupled to the second end, and the second end of the fourth transistor is not connected to the second end of the seventh transistor.
Patent WO-2019157931-A1 (WO)
Title: Supporting bracket for supine reading
Inventor: FU GUOPING
IPC: A47B23/00
Filed: 2019-01-27
Abstract: Provided is a supporting bracket for supine reading, comprising a book supporting structure (1), wherein the book supporting structure (1) comprises a quadrangular frame (11) and one or more tensile strands (12) distributed in an inner region of the quadrangular frame (11); the quadrangular frame (11) contains a first set of opposite sides (111) and a second set of opposite sides (112); and the tensile strands (12) are connected to the first set of opposite sides (111) of the quadrangular frame in a tightened state.
Patent WO-2020133646-A1 (WO)
Inventor: LI WENFANG
IPC: G09G3/20
Filed: 2019-02-20
Abstract: 一种显示装置驱动系统及显示装置驱动方法，显示装置驱动系统中系统芯片（10）经第一I2C总线（40）与开关模块（30）的输入端电性连接，控制板（20）经第二I2C总线（50）与开关模块（30）的输出端电性连接，开关模块（30）的控制端接入控制信号（WP），当控制信号（WP）为预设的第一电位时，开关模块（30）将其输入端与输出端电性连接从而将第一I2C总线（40）与第二I2C总线（50）电性连接，当控制信号（WP）为预设的第二电位时，开关模块（30）将其输入端与输出端断开从而将第一I2C总线（40）与第二I2C总线（50）断开，能够分时将第一I2C总线（40）与第二I2C总线（50）连接或断开，从而在保证系统芯片（10）及控制板（20）之间有效通讯的同时，避免第一I2C总线（40）及第二I2C（50）总线单独工作时信号相互干扰。
Patent WO-2019192299-A1 (WO)
Title: Harq-ack transmission method, terminal, and base station
Inventor: GAO XUEJUAN
IPC: H04L1/16
Filed: 2019-03-13
Abstract: The present disclosure provides a HARQ-ACK transmission method, terminal, and base station, wherein the transmission method comprises: when a physical downlink channel received prior to bandwidth part (BWP) switching requires generating HARQ-ACK feedback after the BWP switching, determining according to a preset rule whether a HARQ-ACK in the physical downlink channel is to be transmitted after the BWP switching.
Patent WO-2019192369-A1 (WO)
Title: Terminal cloud collaboration method, platform and device
Inventor: CHEN JIANJUN
IPC: H04W4/02
Filed: 2019-03-27
Abstract: Disclosed by the present invention is a terminal cloud collaboration method, platform and device, which relates to the communication field. The terminal cloud collaboration method comprises: acquiring, by a cloud platform, current spatial information of each target terminal; tracking the spatial information changes of the each target terminal to obtain the spatial information changing condition of the each target terminal; and determining, according to a spatial information-based arbitration condition respectively predefined by different target mobile applications and the spatial information changing condition of the target terminal respectively corresponding to the different target mobile applications, whether to trigger subsequent operations related to the different target mobile applications. The described method solves the problem in the prior art that the terminal cloud collaboration platform cannot provide native support to user spatial data. The terminal cloud platform performs user spatial information change arbitration to shield uninterested changes, such that proper spatial information changes are provided to the mobile applications, or to trigger subsequent operations of the mobile applications.
Patent WO-2019196798-A1 (WO)
Title: Pixel defining layer, pixel structure, display panel and display device
Inventor: HOU WENJUN
IPC: H01L27/32
Filed: 2019-04-08
Abstract: Provided in the present disclosure are a pixel defining layer, a pixel structure, a display panel and a display device. The pixel defining layer comprises: a plurality of pixel defining patterns (21) arranged in a row direction and a column direction, each of the pixel defining patterns (21) having an opening (22), wherein the openings (22) of at least two adjacent pixel defining patterns (21) in the row direction are different sizes in the row direction, and the minimum distances (a, b, c) in the row direction between the adjacent openings (22) of the pixels defining patterns (21) disposed in the same row are equal. On one hand, the present disclosure may ensure that the widths of two sides of the opening are equal because the minimum distances between two adjacent openings in the same row are equal, thereby ensuring that the micro-environments on both sides of a pixel unit at the opening are the same, which is more advantageous for uniformity of film formation in the pixel unit. On the other hand, the disclosure is more suitable for preparing an organic light emitting device using inkjet printing by means of improving the pixel defining layer.
Patent WO-2020042632-A1 (WO)
Inventor: SUN PINGRU
IPC: H01L33/48
Filed: 2019-04-17
Abstract: Disclosed are a light-emitting means and a manufacturing method therefor, a lead frame (10), a support and a light-emitting device. A support forming area (11) in the lead frame (10) is internally provided with a support portion (12) and a lead portion (13) which extend from the main body of the lead frame (10), the support portion (12) comprises first and second support portions (121/122) arranged opposite each other, the support forming area (11) is used for forming a base main body (20), and the support portion (12) is used for being respectively embedded into a first outer side face (21) and a second outer side face (22), opposite each other, of the formed base main body (20). The support portion (12) on the lead frame (10) extends respectively into bayonets (23) only provided on opposite side faces of an LED product, so as to fix six degrees of freedom of the LED product, improving the stability of the LED product when same is fixed.
Patent WO-2019201348-A1 (WO)
Title: Method and equipment for adjusting waist and back supporting device
Inventor: CHEN DANIAN
IPC: A61B5/11
Filed: 2019-04-19
Abstract: A method for adjusting a waist and back supporting device, wherein the waist and back supporting device comprises a sensing unit and a waist and back control unit; the method comprises: collecting user sensing information of a user by means of the sensing unit when the user wears the waist and back supporting device to use a table and chair (S11); sending the user sensing information to a corresponding user equipment (S12); receiving adjusting instruction information that is returned by the user equipment on the basis of the user sensing information and that is about the waist and back supporting device (S13); and implementing the adjusting instruction information by means of the waist and back control unit so as to adjust the waist and back supporting device to adapt to the state of the table and chair (S14). The described method may acquire in real time posture information of a user and correspondingly adjust the waist and back supporting device according to a change in the posture of the user, such that the user may suitably adjust when wearing the waist and back supporting device to use a table and chair; the process both simplifies tedious operations of the user and greatly improves the user experience.
Patent WO-2020215353-A1 (WO)
Title: Decoration-integrated green building system having assembly-type structure
Inventor: ZHANG HUI
IPC: E04B2/00
Filed: 2019-05-03
Abstract: Disclosed is a decoration-integrated green building system having an assembly-type structure, comprising a building system wall and a separation plate. A first fixed strip is fixed and welded above the surface of the building system wall, and a metal plate is mounted on the inner wall of the first fixed strip; a second fixed strip is fixed and welded below the surface of the building system wall, and a mounting frame is mounted on the inner wall of the second fixed strip; second mounting sides are fixed and welded at the head end and the tail end of the mounting frame; the separation plate is fixed and welded at the inner wall of the mounting frame; moreover, a solar panel is mounted in the mounting frame; lock grooves are formed at the edges of the inner walls of the mounting frame and the separation plate. In a prefabricated assembly-type green building system, the mounting frame and the metal plate are provided in the shape of a triangular prism to form a facade system wrapping a building like cloud, thereby improving the efficiency of building industrialization and prefabricated assembly, improving construction progress, and forming an efficient light shielding system by using a unique facade.
Patent WO-2020227852-A1 (WO)
Title: System for large-scale production of rh2 by means of enzymatic method
Inventor: ZHOU ZHIGANG
IPC: C12M1/38
Filed: 2019-05-10
Abstract: Disclosed is a system for large-scale production of Rh2 by means of an enzymatic method. The production system comprises a reaction kettle, a cooling water circulation device, a hot steam circulation device, an acid storage tank, an alkali storage tank, a measurement device for measuring the degree of reaction in the reaction kettle, a primary solid-liquid separation device for solid-liquid separation treatment of the material from the reaction kettle, a washing tank for cleaning the material subjected to primary solid-liquid separation, a secondary solid-liquid separation device for solid-liquid separation treatment of the material from the water washing tank, and a drying device for drying the material subjected to secondary solid-liquid separation. The production system has a simple structure, complete functions and a compact layout, saves the space and costs, can implement automatic control of a temperature and a pH value, and saves labor.
Patent WO-2019223775-A1 (WO)
Title: Oled plane and drive method therefor, and display apparatus
Inventor: QIN WEI
IPC: G09G3/3208
Filed: 2019-05-24
Abstract: The present invention provides an OLED plane and a drive method therefor, and a display apparatus. The OLED plane provided by the present invention comprises a plurality of pixel units arranged in multiple rows and multiple columns, each pixel unit comprising an OLED device. The OLED plane comprises multiple areas arranged along a column direction, each area comprising at least one row of pixel units and a cathode layer; OLED devices in each area share the cathode layer in the area, and the cathode layer in each area is separated from cathode layers in other areas. The OLED plane comprises a cathode voltage supply circuit which is configured to output a cathode voltage comprising an operating level to the cathode layers. The cathode voltage supply circuit is configured in a mode that the time for outputting the operating level to the cathode layer of at least one area is later than the time when all the pixel units in the area receive a scanning signal.
Patent WO-2020015458-A1 (WO)
Title: Treatment method for waste water from livestock and poultry
Inventor: YAN BIN
IPC: C02F3/30
Filed: 2019-05-27
Abstract: A treatment method for waste water from livestock and poultry, comprising the following steps: performing a preliminary treatment on waste water from livestock and poultry by means of a wetland (1), aquatic plants being planted in the wetland (1), and the preliminarily treated waste water entering a membrane inlet bioreactor (2) for an anaerobic-aerobic cycle treatment, wherein the membrane inlet bioreactor (2) is filled with a hollow fiber membrane (3) which contains a quinone group.
Patent WO-2020029663-A1 (WO)
Inventor: YANG XUDONG
IPC: G06Q30/02
Filed: 2019-05-30
Abstract: 一种商品信息查询方法和系统，基于该系统，可以对线下商品进行拍摄，利用从图像中提取的商品图像特征，查询获得与该线下商品相关的商品信息，从而可以实现在线下场景中，用户不仅能查看到实物，还能通过该系统查询到更多元化的商品信息，提升顾客获得信息的效率。
Patent WO-2020248145-A1 (WO)
Title: 一种五脚猪排的制作方法
Inventor: ZHANG XINGCHUN
IPC: A23L13/10
Filed: 2019-06-12
Abstract: 一种五脚猪排的制作方法，包括以下步骤：a、选取海南五脚猪的猪排，清洗后沥干；b、于低温2～6℃下腌制；c、在0～5℃环境下真空滚揉； d、对滚揉后的猪排进行微波加热，使之达到3成熟，并且定型； e、对定型的猪排的表层，进行酱料涂抹； f、单体速冻，包装。
Patent WO-2020001528-A1 (WO)
Title: 数字微流控芯片及其驱动方法、数字微流控装置
Inventor: ZHAO WEI
IPC: B01L3/00
Filed: 2019-06-27
Abstract: 一种数字微流控芯片及其驱动方法、数字微流控装置。数字微流控芯片包括光驱动层（20）和状态转换层（30），状态转换层（30）用于承载液滴（100），光驱动层（20）用于提供控制状态转换层（30）进行亲疏液性转换以驱动液滴（100）移动的光线，光驱动层（20）包括阵列排布的多个发光单元。通过采用提供光线的光驱动层（20）和能够进行亲疏液性转换的状态转换层（30），使光驱动层（20）通过提供光线控制状态转换层（30）进行亲疏液性转换以驱动液滴（100）移动。
Patent WO-2020119077-A1 (WO)
Title: 一种像素电路、显示装置和像素电路的驱动方法
Inventor: GAI CUILI
IPC: G09G3/3225
Filed: 2019-06-27
Abstract: 本申请部分实施例提供了一种像素电路、显示装置和像素电路的驱动方法。采用本申请的实施例，像素电路包括：第一晶体管(T1)的控制端与扫描线连接，第一晶体管(T1)的第一端与数据线连接，第二晶体管(T2)的第二端连接输出节点；存储器件的第一端与输出节点连接，存储器件的第二端与电源电压(VDD)和第三晶体管(T3)的第一端连接；第二晶体管(T2)的控制端与输出节点连接；第三晶体管(T3)的控制端与控制线连接；第四晶体管(T4)的控制端与输出节点连接，第四晶体管(T4)与发光器件并联连接。
Patent WO-2020019949-A1 (WO)
Title: Copper wire varnish stripping apparatus
Inventor: ZHANG RIPING
IPC: B23D79/12
Filed: 2019-07-03
Abstract: A copper wire varnish stripping apparatus, comprising a bottom plate II (61), wherein a bottom surface of the bottom plate II is provided thereon with a linear motor (112), a top surface of the bottom plate II is provided thereon with a scraper mechanism (4000), and two sides of the scraper mechanism are respectively provided with a pressing mechanism (5000). By means of mounting the linear motor on the bottom plate II, the bottom plate II may be mounted on an assembly line such that the linear motor carries along the bottom plate II to move linearly; the bottom plate II will be provided thereon with a copper wire that has been conveyed over, and by means of pressing, by the pressing mechanisms, two ends of a section of copper wire of the copper wire that has been conveyed over, the copper wire is scraped by the scraper mechanism disposed between the pressing mechanisms. The present varnish stripping apparatus may directly perform a varnish scraping operation on copper wire that is being conveyed, thus saving time and providing a good scraping effect. The present varnish stripping apparatus further collects the varnish coating such that the device is tidy, has good safety, has complete overall functions, and has strong practicability.
Patent WO-2020155581-A1 (WO)
Inventor: ZHANG HAIMIN
IPC: H04L12/58
Filed: 2019-07-22
Abstract: 一种融合货币协议的电子邮件系统，包括：邮件客户端加载有汇款插件，以向用户提供具有汇款标识的电子邮件界面；汇款邮件管理服务器分别与邮件客户端、电子邮件管理服务器和资金管理服务器交互；汇款邮件管理服务器与电子邮件管理服务器和资金管理服务器协同工作，汇款邮件管理服务器接收到邮件客户端发送的邮件消息后，判断邮件消息是否含有汇款标识，若有，汇款邮件管理服务器调度电子邮件管理服务器发送邮件消息及调度资金管理服务器根据汇款标识执行汇款操作，若否，汇款邮件管理服务器仅调度电子邮件管理服务器发送邮件消息。实现信息与价值的同一平台和跨平台同步传输。
Patent WO-2021012157-A1 (WO)
Inventor: XU MENGMENG
IPC: G09G3/20
Filed: 2019-07-22
Abstract: Provided are a color display panel (10) and control method thereof, wherein the color display panel (10) comprises pixel units (100) arranged in an array, each pixel unit (100) comprises at least a red sub-pixel unit (101), a green sub-pixel unit (102), a blue sub-pixel unit (103) and a white sub-pixel unit (104); wherein, the white light of the color display panel (10) is realized by the white sub-pixel unit (104). The white light in the color display panel (10) is realized by the single white sub-pixel unit (104), which can effectively avoid the problem of color separation in the mixed light in the traditional red, green and blue display panel, and improve the display effect of the display panel.
Patent WO-2020020189-A1 (WO)
Title: Compounds as neurokinin-1 receptor antagonists and uses thereof
Inventor: XIANG JIA-NING
IPC: C07D211/12
Filed: 2019-07-24
Abstract: The present invention relates compounds of Formula (A) as NK-1 receptor antagonists, as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses as modulators of dysfunctional glutamate transmission. The present invention also relates to the uses of the compounds or pharmaceutical compositions in treating or preventing certain disorders and diseases which relate to NK-1 receptor in humans. More specifically, the compounds and /or pharmaceutical compositions of the present invention are believed to potentially offer therapeutic benefits to patients who suffer, among others, chemotherapy-induced nausea and vomit (CINV) and /or post-operative nausea and vomit (PONV).
Patent WO-2021051259-A1 (WO)
Title: Centralized remote migration client credential management
Inventor: BOURDAGES SIMON
IPC: H04L9/32
Filed: 2019-09-17
Abstract: A cloud-based network receives a public key of a public/private key pair and a credential for accessing secrets associated with a user network. The cloud-based network receives, from a user interface configured to facilitate remote control of the user network, a command to be executed at the user network. The cloud-based network encrypts, using the public key, the credential and the command. The cloud-based network forwards, to one or more client devices, the encrypted credential and command. The client devices are configured to decrypt the encrypted credential and command using a private key of the public/private key pair and execute the command on the user network.
Patent WO-2020083009-A1 (WO)
Inventor: QI ZHONGCHAO
IPC: B23P15/00
Filed: 2019-09-30
Abstract: 一种激光雕刻多色加工工艺，包括在工厂内完成的以下步骤：1、将铝材冲制成型；2、对铝材表面进行抛光；3、对铝材进行阳极氧化亮光处理，加工出高光亮面；还包括在零售店内完成的以下步骤：4、将个性化图案输入电脑；5、通过激光雕刻机在高光亮面上雕刻出个性化图案；6、在雕刻出的个性化图案外涂上油墨；7、待油墨干后在高光亮面上擦拭掉多余油墨。该种加工工艺一部分在工厂内完成制造，而另一部分能够在零售店完成，满足零售店内快速的加工个性签名及图案的需求，并且操作简单，无毒无害，快速制作取件。
Patent WO-2020168728-A1 (WO)
Inventor: KANG XIAOXU
IPC: H01L27/146
Filed: 2019-10-14
Abstract: A CMOS imaging sensor structure and a manufacturing method therefor. The CMOS imaging sensor structure comprises a pixel unit of a CMOS imaging sensor provided on a semiconductor substrate (104). The pixel unit is provided with a circuit component area and a first photosensitive area. The circuit component area is provided on the front side of the substrate (104). The first photosensitive area is correspondingly provided in the substrate (104) under the circuit component area. The circuit component area and the first photosensitive area are separated by a separation area (102). The circuit component area and the first photosensitive area are electrically connected to each other via an electrically-conductive groove (109). This allows the fill factor of the photosensitive area to be increased and, at the same time, uses a further optimized design plan to increase the performance of a reading circuit. A second photosensitive area of the pixel unit can also be provided on the substrate (104) on one side of the circuit component area so as to provide a larger photosensitive area together with the first photosensitive area.
Patent WO-2021022672-A1 (WO)
Title: 一种涂布装置及涂布方法
Inventor: ZHANG QIFA
IPC: B05C13/02
Filed: 2019-10-16
Abstract: 一种涂布装置及涂布方法，基材（8）位于动力悬浮辊（1）和涂布头（3）之间，基材与气体均布器（14）之间有间隙，涂布头与气体均布器相对设置，可实现基材两面同时涂布。与刚性涂布辊相比，基材在有间隙时的涂布面密度更均匀，不会出现基材被挤断的现象。
Patent WO-2020098463-A1 (WO)
Inventor: KANG BO
IPC: H02M3/158
Filed: 2019-10-23
Abstract: Disclosed is a buck-boost circuit. The circuit is an improvement based on a conventional four-transistor buck-boost circuit, and is obtained by eliminating a switch device S3 therein, reusing a switch device S2 in a boost mode so as to eliminate one switch transistor, and connecting an inductor in series between a source of a switch device S1 and a drain of the switch device S2, such that the circuit has different turn ratios in different modes. When the circuit is in a buck mode, under a condition of a ratio of an input voltage to an output voltage being the same, a duty cycle of the switch device S1 for a turn ratio greater than 1 is greater than that for a turn ratio equal to 1, and when the circuit is in the boost mode, a duty cycle of the switch device S2 for a turn ratio greater than 1 is less than that for a turn ratio equal to 1. The invention is configured such that the circuit is applicable to power supply applications where an input voltage is less than, equal to, or greater than an output voltage, and also for power supply applications having a large transformation ratio between an output and an input.
Patent WO-2020119298-A1 (WO)
Title: 基于区块链的事件处理方法及装置、电子设备
Inventor: HUANG ZHANGJIE
IPC: G06Q40/02
Filed: 2019-10-29
Abstract: 一种基于区块链的事件处理方法及装置、电子设备，当应用于参与方时，该方法包括：根据所述参与方所参与的事件，生成对应的备选子交易，以使得若干备选子交易被聚合为集合交易；其中，所述备选子交易设定有对应的状态变化量，以用于使所述参与方的状态参数基于所述状态变化量而发生相应的数值变化，且所述状态参数的取值、所述状态变化量分别为基于同态加密算法或同态承诺算法计算得到（102）；针对所述集合交易中相邻且对应的事件均用于减小所述状态参数的取值的多个备选子交易，生成统一证明信息，以证明所述状态参数在经过所述多个备选子交易后的取值处于正确取值区间（104）；将所述集合交易提交至区块链，以使所述集合交易中包含的备选子交易被依次处理（106）。
Patent WO-2021087840-A1 (WO)
Title: Tumor immunotherapy polypeptide and application thereof
Inventor: QIU SI
IPC: C12N15/12
Filed: 2019-11-07
Abstract: Provided are a tumor immunotherapy polypeptide and an application thereof. The polypeptide comprises at least any polypeptide in a first peptide group, and can optionally comprise at least any polypeptide in a second peptide group; the first peptide group comprises polypeptides the amino acid sequences of which are represented by SEQ ID NO: 1 to SEQ ID NO: 6 and first derivative peptides; and the second peptide group comprises polypeptides the amino acid sequences of which are represented by SEQ ID NO: 7 to SEQ ID NO: 15 and second derivative peptides thereof. Further provided are a use of an isolated nucleic acid, a construct, an expression vector, a host cell, a pharmaceutical composition, an antigen-presenting cell, an immune effector cell, a tumor vaccine, and a polypeptide in the preparation of a drug for preventing or treating tumors, and a method for treating patients suffering from tumors.
Patent WO-2020253094-A1 (WO)
Title: 一种氮化硼纳米管气凝胶/相变导热复合材料及其制备方法
Inventor: ZENG XIAOLIANG
IPC: C09K5/06
Filed: 2019-11-21
Abstract: 本发明涉及一种氮化硼纳米管气凝胶/相变导热复合材料及其制备方法，其包括以下步骤：（1）将氮化硼纳米管原料以氧化石墨烯溶液混合分散均匀，得到均匀的氮化硼纳米管/氧化石墨烯分散液；（2）向所述氮化硼纳米管/氧化石墨烯分散液中滴加还原剂，在加热条件下水热还原得到水凝胶，接着进行真空冷冻干燥得到氮化硼纳米管气凝胶；（3）在加热条件下，向所述氮化硼纳米管气凝胶中滴加融化的固-液有机相变材料，接着转入真空条件下加热以除去残留气泡，冷却至室温即得到氮化硼纳米管气凝胶/相变导热复合材料。本发明制备的相变复合材料导热性能和储热性能高。
Patent WO-2020108425-A1 (WO)
Inventor: LIAO LIANGFEI
IPC: H04N5/225
Filed: 2019-11-25
Abstract: Disclosed is a camera hole cover plate, comprising: a cover plate main body comprising a transparent area used for covering a display screen, and a cover plate edge, wherein the cover plate edge and the cover plate main body are of an integrated structure; the cover plate edge is arranged so as to surround the cover plate main body; and an area, outside the transparent area, of the cover plate edge comprises a frosted area.
Patent WO-2021102793-A1 (WO)
Inventor: YU YONGCHANG
IPC: H03G3/20
Filed: 2019-11-28
Abstract: Provided are an operational amplifier, a chip and an electronic device, which can increase the stability and establishment speed of a common mode feedback circuit. The operational amplifier comprises: N stages of amplifiers connected in series, and M common mode feedback circuits, wherein N and M are integers, N≥3, and N≥M>1; an ith common mode feedback circuit in the M common mode feedback circuits is used for detecting the common mode output voltage of an amplifier of the (j+b)th stage, and adjusting an electrical parameter of at least one amplifier among amplifiers of the jth to (j+b)th stages, so as to stabilize the common mode output voltage of the amplifier of the (j+b)th stage; the M common mode feedback circuits are used for detecting and stabilizing the common mode output voltage of an amplifier of the Nth stage; and i, j and b are integers, M≥i≥1, N≥j≥1, i≥j, and b≥0.
Patent WO-2020135318-A1 (WO)
Inventor: CHANG XIAOTIAN
IPC: A61P19/02
Filed: 2019-12-23
Abstract: 提供了CD38抑制剂在制备抗类风湿关节炎药物中的应用。研究表明RA患者血液和滑液中CD38＋NK细胞含量、CD38＋NK／CD38＋NKT比例升高，变化情况与患者DAS28呈正相关，启示了CD38＋NK细胞、CD38＋NKT细胞有望成为RA的治疗靶点。进一步研究表明，RA中高水平的CD38＋NK及CD38＋NK／CD38＋NKT比值可以降低TGF-β分泌和激活MNC中CD4＋T细胞mTOR通路，抑制CD4＋T细胞分化Treg细胞及IL-10表达、提升IFN-γ水平和Thl／Th2、Thl7／Treg比值，导致抗炎和免疫耐受能力降低，加剧RA病程。