baber/WOPTO huggingface dataset:
Patent CR-20190343-A (CR)
Title: FORMAS DE DOSIFICACIÓN DE LIBERACIÓN PROLONGADA PARA UN INHIBIDOR DE JAK 1 (Divisional de Exp: 2016-0102)
Inventor: YELESWARAM KRISHNASWAMY
IPC: A61K31/4045
Filed: 2014-08-06
Abstract: La presente invención se refiere a formas de dosificación de liberación prolongada que comprenden {1-{1-[3-fluoro-2-(trifluorometil)isonicotinoil]piperidin-4-il}-3-[4-(7H-pirrolo[2,3-d]pirimidin-4-il)-1H-pirazol-1-il]azetidin-3-il}acetonitrilo o una sal farmacéuticamente aceptable de este y dosis y métodos relacionadas con estas.
Patent CR-20200409-A (CR)
Title: Novel peptides and combination of peptides for use in immunotherapy against epithelial ovarian cancer and other cancers
Inventor: RAMMENSEE HANS-GEORG
IPC: C07K14/47
Filed: 2016-07-14
Abstract: <p>The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor- associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.</p>
Patent CR-20210068-A (CR)
Title: Novel peptides and scaffolds for use in immunotherapy against head and neck squamous cell carcinoma and other cancers
Inventor: FRITSCHE JENS
IPC: C07K14/47
Filed: 2017-08-24
Abstract: <p>The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.</p>
Patent EC-SP003329-A (EC)
Title: Relajantes neuromusculares de aralquilo y aralquenilo mono-aciloxi sustituidos
Inventor: LEE CHINGMUH
IPC: A61K31/46
Filed: 2000-02-01
Abstract: La invención se describe una serie de derivados de bis-amonio cuaternario de aralquilo y aralquenilo aciloxi sustituidos de diversos ésteres de aminoalcanoles cíclicos de ácidos dicarboxílicos como relajantes musculares, métodos para prepararlos y usarlos y composiciones farmacéuticas que los contienen. El primer aspecto de esta invención es un grupo de compuestos 1/a, que tienen la fórmula general ilustrada a continuación: (gráfico), un segundo aspecto de esta invención es un grupo de compuesto 1/b que tienen la fórmula general ilustarda a continuación: (gráfico), donde R1 y R1 son aralquilo o aralquenilo mono-aciloxi sustituido; R2 y R2¿son alquilo, alquenilo o alquinilo; A es alcanodicarbonilo, alquenodicarbonilo, alquinodicarbonilo, cicloalcanodicarbonilo, cicloalquenodicarbonilo, bicicloalcanodicarbonilo, bicicloalquenodicarbonilo, policicloalcanodicarbonilo, policicloalquenodicarbonilo o dicarbonilo aromático, normales o sustuidos; n es 0,1 ó 2; m es 0,1 ó 2; p es 0,1 ó 2; R3 y R3¿son H CH3 o alquilo inferior; R4 y R4¿son H, CH3, ó alquilo inferior; R3 y R4 juntos tambi¿n pueden ser -CH=CH-, -(CH")h-Y-(CH2)K-, ó -CH -CH-, donde Y es CH2, O ó S; h es 0,1,2 ó 3; K es 0, 1,2 o 3; donde R1 Y R1¿, R2 Y R2¿, R3 Y R3¿, Y R4 Y R4¿pueden ser iguales o diferentes; X es un anión farmacéuticamente aceptable. Un cuarto aspecto de esta invención es el método de uso de los compuestos de las fórmulas generlaes 1/a-1/b como relajantes neuromusculares. El quinto aspecto de esta invención es una composición farmacéutica que incluye los compuestos de las fórmulas generales a y b y un excipiente farmacéuticamente aceptable.
Patent EC-SP024393-A (EC)
Title: Derivados biciclicos sustituidos para el tratamiento del crecimiento celular normal
Inventor: KATH JOHN CHARLES
IPC: C07D239/94
Filed: 2002-12-13
Abstract: La invención se refiere a compuestos de fórmula I: Y a sales solvatos o profármacos farmacéuticamente aceptable de los mismos, en los cuales R1, R3, R4, R5, R11, m y p son tales como se han definido en la presente memoria. La invención se refiere también a métodos para tratar el crecimiento celular anormal en animales mamíferos administrando los compuestos de fórmula I, y a composiciones farmacéuticas para tratar los trastornos, que contienen los compuestos de la fórmula I. La invención se refiere también a métodos para preparar los compuestos de fórmula I.
Patent EC-SP034749-A (EC)
Title: Sales farmaceuticas
Inventor: BARTHOLOMAEUS JOHANNES HEINRICH
IPC: C07D307/78
Filed: 2003-08-27
Abstract: El presente invento se refiere a sales farmacéuticas a base de una sustancia activa farmacéutica y por lo menos una sustancia sustitutiva de azucares, medicamentos que contienen estas sales, así como la utilización de estas sales para producir medicamentos.
Patent EC-SP066648-A (EC)
Title: Metodologia sintetica para la alquilacion reductiva en la posicion c-3 de indoles
Inventor: RAVEENDRANATH PANOLIL
IPC: C07D417/02
Filed: 2006-06-16
Abstract: La presente invención describe un proceso para la alquilación reductiva en la posición C-3 de un compuesto de indol en el que el indol se trata con un aldehído en presencia de un ácido de Lewis y un agente reductor de hidruro de silicio. El proceso es útil para la alquilación en la posición C-3 de indoles que contienen sustituyentes sensibles a ácidos en la posición N-1.
Patent EC-SP088624-A (EC)
Inventor: ESPELETA VEGA ALICIA
IPC: A23L13/60
Filed: 2008-07-15
Abstract: A process for elaborating a casing-less sausage- or similar-type food product, the process comprises the steps consisting in preparing an emulsion-type sausage paste having a gel-like viscosity; extruding the sausage paste into portions of a predetermined shape, which maintain said shape and which have at least one essentially flat suface; cooking the upper and lower surfaces of the said portions in order to form a skin that is obtained by applying heat to the external sausage paste of said portions, thereby leaving a core which is surrounded by the skin and which consists of the sausage paste that was not used to form the skin; performing a second cooking step in order to cook the cores, thereby forming sausage-type food products; and finally cooling the sausage-type food products prior to packing. The product thus obtained consists of a body which has at least one essentially-flat surface and which has a skin that is obtained upon heating, and a core which is surrounded by the skin and which consists of the cooked sausage paste that was not used to form the skin.
Patent EC-SP961817-A (EC)
Title: Nuevo procedimiento para la preparacion de norbenzomorfano, una etapa intermedia en la preparacion de derivados de benzomorfano farmaceuticos valiosos, especialmente de (-) - (1r, 5s, 2'' r)-3-(hidroxi - 2 - (2- metoxi- propil)- 5, 9, 9 - trimetil- 6
Inventor: GRAUERT MATTHIAS
IPC: C07C229/34
Filed: 1996-07-09
Abstract: La presente invención se refiere a un nuevo procedimiento para la preparación de norbenzomorfano que es la etapa intermedia central en la preparación de derivados de benzomorfano de la fórmula general 1, farmacéuticamente valiosos. (gráfico), en particular (-)-(1R,5S,2¿R¿)-3¿-HIDROXI - 2 - (2-METOXI-PROPIL)-5,9,9-TRIMETIL-6,7-BENZOMORFANO O [(-)-(2R, 6S, 2¿R)- 3- (2-METOXI-PROPIL)-6,11,11-TRIMETIL-1,2,3,4,5,6-HEXAHIDRO -2,6 -METANO, BENZO [] OXACIN -9-01](BIII 277).
Patent EC-SP982396-A (EC)
Title: Composiciones que contienen tetrahidrolipstatina
Inventor: ESCRIBANO ANA MARIA
IPC: A61K38/43
Filed: 1998-02-04
Abstract: El invento se refiere a un producto conteniendo tetrahidrolipstatina como ingrediente activo y excipientes farmacéuticamente aceptables, caracterizado porque está en forma de partículas como un diámetro de 0.25 a 2mm; y preparaciones o composiciones farmacéuticas para administración oral que contiene dicho producto.
Patent EC-SP982799-A (EC)
Title: Inhibidores de sodio intercambio de protones de acil guanidina y metodo de utilizacion
Inventor: DUGAR SUNDEEP
IPC: C07D217/02
Filed: 1998-12-21
Abstract: Se proporciona acil guanidinas las cuales son inhibidores de intercambio de protones/sodio (NHE), las cuales tienen la estructura (gráfico), en donde n es 1 a 5; X es N o C-R5 en donde R5 es H, halo, alquenilo, alquinilo, alcoxi, alquilo, arilo o heterorilo; y R1, R2, R3 y R4 son como se definieron aqui, y en donde X es N, N1 es preferentemente arilo o heteroarilo, y son útiles como agentes antianginales y cardioprotectores. Además, se proporciona un método para prevenir o tratar la angina pectoris, la disfución cardiaca, la necrosis miocardiaca, y la arritmia empleando las acil guanidinas anteriores.
Patent FI-20021808-A (FI)
Inventor: CHERRY DARREL D
IPC: H04W4/02
Filed: 2002-10-10
Abstract: Information systems for providing information to a user are provided. In this regard, a representative information system includes a location-specific input system that is configured to communicate with a communication network. The location-specific input system also is configured to receive an input from a user, determine a location of the user, and enable information corresponding to the input of the user and the location of the user to be provided to the communication network. Methods and other systems also are provided.
Patent GB-1047397-A (GB)
IPC: G03D3/13
Abstract: 1,047,397. Photographic processing apparatus. A. ARNOLD [trading as ARNOLD & RICHTER, KOMM. GES.] July 23, 1963 [July 25, 1962], No. 29140/63. Heading G2A. The apparatus described is substantially identical with that of Specification 1, 047, 396. Emphasis is placed in the claims on the frame 2 having parallel shafts 3, 4, 4' for carrying the rollers, those on shaft 3 running freely and those on shafts 4, 4' being fixed thereto. The upper shaft 3 projects outside the frame, and carries means (e.g. gear wheel 13) for engagement with a drive mechanism. The drive is transmitted to the lower shafts by chains 11, 12. The frame also has centering pins 30 which engage in corresponding channels 31 in the tank 1 to ensure correct location.
Patent GB-1050921-A (GB)
IPC: B41B21/16
Abstract: 1,050,921. Photographic type-composing machines. MONOTYPE CORPORATION Ltd. and D. C. GOODALL. June 21, 1963 [July 4, 1962], No. 25664/62. Heading B6W. Light from a source 11 passes through a movable matrix case 13, an optical member 23, prisms 16, a lens 15, and a mirror 17, 17 traversed stepwise, to a photosensitive surface 18 on a drum 19. The member 23 is tiltable in response to a " shift " signal in the controlling record tape so as to shift the character image downwards on the surface 18. A matrix for a " superior " character is used with the " shift " signal to expose the corresponding " inferior " character. The member 23 is tilted by a pneumatic piston acting on an arm 27. To expose " superior " and " inferior " characters in the same vertical line, a " double expose " signal is used which after the " shift " exposure, prevents the normal movement of the mirror 17 until the normal exposure has been made.
Patent GB-1050961-A (GB)
IPC: C01B25/234
Abstract: 1,050,961. Concentrating orthophosphoric acid. FISONS FERTILIZERS Ltd. March 24, 1964 [April 6, 1963], No. 13776/63. Heading BIB. Concentrated orthophosphoric acid is prepared by mixing an aqueous solution of orthophosphoric acid with a miscible organic compound (entrainer) and distilling the mixture at a pressure of less than 110 millimetres of mercury and at a temperature below 150‹C., the water and entrainer distilling over leaving concentrated orthophosphoric acid as the residue which may then be crystallised by cooling with seeding. The entrainer has a boiling point below 170‹C. and is selected from carboxylic acids of 1-5 carbon atoms, alcohols, esters, ketones and ethers, the amount of entrainer used being in the range of 30-300%, or preferably 70-200%, by weight of the aqueous orthophosphoric acid. The distillation is carried out at preferably below 110‹C. The orthophosphoric acid obtained is concentrated to at least 95% by weight. Crystallised acid may be recrystallised by warming with a minute amount of water to melt, and cooling with seeding. The aqueous orthophosphoric acid may be obtained by the wet process and the electrothermal process.
Patent GB-1051148-A (GB)
IPC: H01R13/625
Abstract: 1,051,148. Two-part couplings. PLESSEYU.K. Ltd. July 25, 1963 [Aug. 28, 1962], No. 32974/62. Heading H2E. [Also in Divisions E2 and F2] A two-part coupling (e.g. for an electrical connector) has two parts 1, 5 each carrying half a bayonet fitting, one of these halves 9 being movable relative to the coupling part 5 (and being threadedly mounted upon a collar 8 which can rotate about the part 5) to increase the pressure upon the sealing rings 13, 14. The collar 8 is locked in its final position by the spring washer 15, and this washer also provides a slight spring tension for the bayonet assembly when the peg 11 on part 5 is engaged in the bayonet track 2 in part 1 of the coupling. A plug 7 is thereby engaged with a socket 4 in an electrical connector. The invention may be applied to hydraulic or pneumatic connectors.
Patent GB-1051554-A (GB)
IPC: B41M5/323
Abstract: 1,051,554. Heat-sensitive compositions. ALLIED CHEMICAL CORPORATION. March 11, 1964 [March 15, 1963], No.10338/64. Heading G2C. Heat-sensitive compositions comprise, suspended in a non-reactive, film-forming binder, (i) a bis(p-dialkylaminoaryl)methane in which one of the methane hydrogen atoms has been replaced by an alkylamino, heterocyclic nitrogen or sulphonamide group in solid form and (ii) an acid-reacting substance which is (a) a solid non-tautomeric acid having a dissociation constant of at least 1 x10<SP>-10</SP> (b) the anhydride of such an acid, (c) a solid acid-reacting salt of an acid having a dissociation constant of at least 1 x 10<SP>-10</SP>, said salt being at least 0À5% soluble in water at 20‹C., or (d) a solid prototropic acid having in one form a dissociation constant of at least 1 x 10<SP>-4</SP>. The composition is coated onto a support, or the components (i) and (ii) each separately suspended in binder may be successively coated onto a support, to form a heatsensitive copy sheet. Acid-reacting substances specified are succinic, stearic, gallic, sulphamic and maleic acids, their anhydrides, mono-sodium acid citrate, potassium alum, aluminium sulphate, potassium acid tartrate, sodium acid phosphate, ammonium gallate, ammonium benzoate, dichlorobenzidine dihydrochloride, 2-amino-5-naphthol- 7-sulphonic acid, saccharin, barbituric acid and uric acid.
Patent GB-1051966-A (GB)
IPC: A47G9/10
Abstract: 1,051,966. Pillows. R. URBACH. Aug. 16, 1965 [Feb. 20, 1965], No. 7414/65. Heading A4M. A pillow is divided by a centre partition parallel to the face of the pillow into two compartments, one containing down and the other soft selected feathers.
Patent GB-1098365-A (GB)
Abstract: 1,098,365. Moving coil meters. ZAVOD "VIBRATOR". Feb. 17, 1966, No.6964/66. Heading G1Q. The coil of a magnet-cored moving coil meter is torsionally suspended by a pair aligned taut bands 2, 3 the inner ends of which are secured within the core magnet and the outer ends secured to tensioning springs 16, 17 mounted in holders 18, 19 carried by the coil. The springs each consist of a spirally slotted disc. The core magnet 4 has a central bore in which is fitted an insulating bush 5. The inner end of the lower taut band 3 is secured to a fixed terminal 10 and passes along a recess in the outside of the bush and thence through a radial hole into an axial bore in the bush where it is clamped between pin 6 and wedge 8. From the clamp it passes downwardly through the bore and through the coil 1 and is wrapped around a pin 14 in the lower holder 18 on the coil. It is terminated on the outer periphery of the spring 16 in this holder. The mounting of the upper taut band 2 is identical, but some of the relevant components are not visible in Fig. 1 since they are disposed generally perpendicular to the corresponding components of the lower band. The bands are tensioned by rotating the springs in their holders. Covers 23, 24 protect the adjusted movement from disturbance and also serve to exclude dust.
Patent GB-1143551-A (GB)
IPC: F23Q2/52
Abstract: 1,143,551. Gas storage containers. COLIBRI LIGHTERS Ltd. 22 Dec., 1967 [11 Jan., 1966], No. 1484/67. Heading F4P. A compressed gas storage cartridge suitable for re-filling a gas burning cigarette lighter comprises a two-part shell 4, 5, the part 4 being formed with a neck 6 which provides a housing for a discharge valve 9 and for its seating 8 against which the valve is held by a spring 14, whilst part 5 provides reaction for said spring when an upper stem 10 of the valve 9 is pushed down to discharge the gas. The parts 4, 5 are made of plastics and are welded together at their abutting edges. A recess 15 in the part 5 allows stacking of a plurality of cartridges. In a modification, the lower part 5 is of transparent plastics material and is graduated to indicate the amount of residual gas which is in the liquid phase.
Patent GB-1225444-A (GB)
IPC: G05D23/24
Filed: 1969-10-28
Abstract: 1,225,444. Automatic temperature control. GENERAL ELECTRIC CO. Oct.28, 1969 [Nov. 29, 1968], No.52639/69. Heading G3R. An element 1 for controlling the heating of an oven is itself controlled by contacts 11 of a hot wire relay 10 which are closed and opened respectively by the energization and de-energization of a heated wire actuator 12, the energization being dependent upon the action of a threshold switching element 20 and a controlled switching element 13 the conductivities of which are determined by voltage dividers, one of which includes a temperature responsive resistor 24 sensitive to the oven temperature and the other of which includes a positive temperature co-efficient resistor 28 which provides ambient temperature compensation. When the oven is required for baking the manually operated contacts 36, 37 are opened, the oven temperature then being controlled to a valve set by a variable resistor 30. When the apparatus is to be used to clean the oven contacts 36, 37 are closed thus short circuiting the variable resistor 30 and placing a variable resistor 35 in parallel with the thermistor 24. The oven temperature is now controlled to a temperature set by the variable resistor 35, this temperature being considerably higher than the cooking temperature. The action of the heated wire actuator 12 when connected in series with the oven temperature sensing thermistor 24 is to obviate chattering of the contacts 11 of the relay. The element 1 may be an electric heating element in an electric oven or the operating coil of a solenoid in the gas supply to a gas heated oven. In an alternative arrangement the hot wire relay 10 may be connected on the A.C. side of the diode 25.
Patent GB-1226120-A (GB)
IPC: F22G5/00
Filed: 1968-11-26
Abstract: 1,226,120. Determining quality of steam. TEXACO DEVELOPMENT CORP. Nov.26, 1968 [Nov.30, 1967], No.1728/70. Divided out of 1226119. Heading G1S. [Also in Division B1] The description is identical to that described in the parent Specification but the claims are directed to a process in which wet steam is injected into an underground hydrocarbon-bearing formation, the quality of the wet steam being determined by adiabatically expanding a sample of the wet steam, separating the liquid in the sample, comparing the chloride ion content of the separated liquid with that of the feed water used to generate the steam to determine the quality of the sample, and deriving the quality of the wet steam from the quality of the sample.
Patent GB-1231143-A (GB)
IPC: G02B5/30
Filed: 1969-01-13
Abstract: 1,231,143. Optical apparatus. POLAROID CORP. Jan. 13, 1969 [Jan. 11, 1968], No. 1929/69. Heading G2J. In order to obviate the chromatical portrayal of the stress pattern produced in a stressed aircraft window having polariscopic attenuation, a wave plate producing at least a four wavelength retardation on midspectrum light i.e. 575 mÁ is interposed between the birefringent window and polarizer so that the profusion of colours so produced are to an observer individually indistinguishable and thus viewed as white light. As shown, light passes serially through a first stressed, structural polymethyl methacrylate (P.M.M.A.) member, a second, structural P. M. M. A. window member which may be stressed, a polyethylene terephthalate wave plate which produces a fifteen wavelength retardation and is bonded to a fixed polarizing unit and a rotatable analysing unit B to an observer (not shown). The polarizing and analysing units A, B are each formed by laminating a polarizing sheet of polyvinyl alcohol between two protective layers of cellulose acetate butyrate sealed between P. M. M. A. support elements. Attenuation efficiency may be improved by providing a second fixed polarizing unit having its axis parallel to the first polarizing unit, the rotatable analysing unit being placed therebetween. The wave plate may be free standing or bonded to one of the faces of either the first or second structural window members.
Patent GB-1231145-A (GB)
IPC: F16L3/123
Filed: 1969-01-20
Abstract: 1,231,145. Spring clips. ILLINOIS TOOL WORKS Inc. 20 Jan., 1969 [22 Jan., 1968], No. 3162/69. Heading E2B. [Also in Division A4]  A spring clip suitable for supporting an electrical conductor, is a one-piece construction of electrically insulating material, and includes a base 12 which has a first surface for adhesive attachment to a support member 15 and an opposite second surface from which projects an arm 16, the free end of the arm normally lying substantially adjacent to the second surface but being resiliently bendable away from the second surface to permit the reception therebetween of the said conductor, the part of the base which lies near the free end of the arm having a thickness generally equal to that of the arm, and the part of the base in the vicinity of its junction with the arm being of greater thickness to withstand forces arising from the said bending of the arm, which forces would otherwise cause the central portion of the base to detach from the said supporting surface. In the construction shown the stronger part of the base plate when viewed in transverse section progressively increased in thickness from the part having the thickness substantially equal to that of the arm to a maximum thickness at the junction of the arm with the base plate. Adjacent the free extremity of the arm the base has a thickened area 24 and the free extremity is in the form of a lateral lip 22 which presents a surface flaring away from the small thickened area of the base plate.
Patent GB-1231666-A (GB)
IPC: A47D11/00
Filed: 1968-09-06
Abstract: 1,231,666. Cots; play pens; furniture conversions. BLOWER BROS. (NOTTINGHAM) Ltd. 15 May, 1969 [6 Sept., 1968], No. 42399/68. Headings A4H and A4U. A cot having side walls 2 detachably connected to rectangular end members 1 by threaded studs extending through apertures 3, 4 and each secured by a nut, is connected to a play pen by disconnecting the end members, turning them through 90 degrees and re-connecting them to the side frames utilizing apertures 3. A spring base for a mattress is supported on a ledge on a rail of the side walls.