Patent SG-11201806946V-A (SG)
Title: Epigenomic profiling reveals the somatic promoter landscape of primary gastric adenocarcinoma
Inventor: TAN PATRICK
IPC: G01N33/68
Filed: 2017-02-16
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 1111111101111011101010111110101111101110101111101011111111011111111101111011111 International Bureau 0.. .... .. ...... ... (10) International Publication Number (43) International Publication Date WO 2017/142484 Al 24 August 2017 (24.08.2017) WI P0 I P CT (51) International Patent Classification: G01N 33/68 (2006.01) G01N 33/574 (2006.01) C12Q 1/68 (2006.01) (21) International Application (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 10201601142V 16 February 2016 (16.02.2016) (71) Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH [SG/SG]; Connexis North Tower, Singapore 138632 (SG). (72) Inventors: TAN, Patrick; pore, 60 Biopolis Street, 138672 (SG). QAMRA, (74) Agent: SPRUSON & FERGUSON (ASIA) PTE LTD; C12N 15/113 (2010.01) P.O. Box 1531, Robinson Road Post Office, Singapore A61P 35/00 (2006.01) 903031 (SG). (81) Designated States (unless otherwise indicated, for every Number: kind of national protection available): AE, AG, AL, AM, PCT/SG2017/050072 AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, 16 February 2017 (16.02.2017) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, English KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, English NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, SG TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 1 Fusionopolis Way, #20-10 (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, c/o Genome Institute of Singa- TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, #02-01 Genome, Singapore TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Aditi; c/o Genome Institute of DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, #02-01 Genome, Singapore LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, c/o Genome Institute of SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, #02-01 Genome, Singapore GW, KM, ML, MR, NE, SN, TD, TG). Fong; c/o Genome Institute of #02-01 Genome, Singapore Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) [Continued on next page] Singapore, 60 Biopolis Street, 138672 (SG). XING, Manjie; Singapore, 60 Biopolis Street, 138672 001, Wen (SG). Singapore, 60 Biopolis Street, 138672 (SG). REVEALS THE SOMATIC PROMOTER LANDSCAPE OF PRIMARY GASTRIC AD- FIG. I Somatic Gain (CEACAM6) CEACAM5 (54) Title: EPIGENOMIC PROFILING = ENOCARCINOMA - II II I II •• I m 5, 77 —Go .i.. t ........___............. 77 — I Normal tk. 231 — \"GC Lin 5000 GC 1-1 .4 7 GO 71- ei 71- 1-1 ----- (57) : The present invention IN associatedpromoter, or a method C to H3K4me1 greater than 1 and ei sample relative to the non-cancerous biological sample. A biomarker for cancer detection comprising a promoter having the change O in signal intensity of H3K4me3 in the cancerous biological sample relative to a non-cancerous biological sample is also disclosed herein. In a separate invention, ulating the immune response is further disclosed, each involving an administered inhibitor of EZH2. 5[140 Normal cht19:42,197,907-42,28400 25K b relates to a method for determining the presence or absence of at least one promoter or cancer for cancer prognosis, each based on the isolation of a nucleic acid having signal ratio of H3K4me3 detecting the change in signal intensity of H3K4me3 in the nucleic acid in the cancerous biological a method for modulating the activity of at least one cancer-associated promoter or a method for mod- WO 2017/142484 Al 1#11101MONEMIMME 30101110101111MMEHEVOIMIE • \"\"\"°\"\"`' — with sequence listing part of description (Rule 5.2(a)) — with international search report (Art. 21(3))