baber/WOPTO huggingface dataset:
Patent DE-60311812-T2 (DE)
Inventor: LACRAMPE Jean Fernand
IPC: A61P35/00
Filed: 2003-07-08
Granted: 2007-11-22
Abstract: The present invention concerns the compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein m, n, R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4 </SUP>and R<SUP>5 </SUP>are as defined herein, the use of such compounds as inhibitors of cyclin-dependent serine/threonine kinases (Cdks), as well as kinases and phosphatases involved in cell cycle regulation such as the tyrosine kinases Wee1, Mik1 and Myt1 or the tyrosine dephosphatases such as Cdc25 and Pyp3. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating cell proliferative disorders such as atherosclerosis, restenosis and cancer.
Patent DE-60316001-T2 (DE)
Inventor: WALCHLI JEAN-CLAUDE
IPC: A23C19/06
Filed: 2003-10-08
Granted: 2008-05-15
Abstract: The cheese product is made from curds obtained from coagulated raw milk and/or pasteurised milk sprinkled with a raising agent.   The curds are compressed into a cheese that is allowed to mature for 8 - 16 hours at 16 - 22 deg C. before being granulated. The grains are allowed to mature for a second time for a period of 6 - 12 hours at 16 - 22 deg C. and then salted and poured into a vertical tubular moulder with extruders to produce cylinders or blocks of cheese that are ready to be cut and packed in individual portions. The moulder and/or extruders can be micro-perforated and be connected to a shaper with blades. The cheese, which can be produced as a savoury, flavoured or sweet product, can be subjected to anti-bacterial treatment before or after packaging, e.g. by ionisation or sterilisation.
Patent DE-68903418-T2 (DE)
Inventor: GELLERT JOBST ULRICH
IPC: B29C45/30
Filed: 1989-04-13
Granted: 1993-03-25
Abstract: This invention relates to a hot tip gated multi-cavity injection molding system wherein an elongated heated probe (10) extends centrally in a straight portion (26) of the melt passage (14) leading to each gate (18) in a position wherein a tip end (30) of the probe (10) is centrally aligned adjacent the gate (18). One part of the straight portion (26) of the melt passage (14) is formed by a locating sleeve (42) which is seated in the cavity plate (16) and has spaced pins (52) which extend inwardly to contact the outer surface (28) of the probe (10) to accurately locate the probe (10) with the tip end (30) in central alignment with the gate (18). Each probe (10) has a central heating element (74) with a double thickness portion (78) extending to provide additional heat where the pins (52) contact the probe (10). One of the pins (52) is hollow to receive a thermocouple (108) to measure the temperature of the melt flowing past the pins (52). Another part of the straight portions (26) of the melt passage (14) is formed by a cylindrical spacer collar (58) which extends between the manifold (12) and each locating sleeve (42) to provide an insulating space (66) of a curtain width between the manifold (12) and the cavity plate (16).
Patent DE-68904332-T2 (DE)
Inventor: SCHNEIDER JAMES GERARD
IPC: A61M1/00
Filed: 1989-03-16
Granted: 1993-05-06
Abstract: An autotransfusion device usable with a chest drainage unit includes a collapsible fluid collection bag assembly (16) having a pliable fluid collection bag (64), a pair of stiffener members (76, 78) adjacent the opposed sides of the bag, and an enclosure (80) sealingly connected to the bag securing the stiffeners in place. A fluid inlet (22), gas outlet (30), and a blood outlet (73) are connected to the bag. A holder (18) is dimensioned to compress the opposed edges of the bag assembly to cause the stiffeners to bow outwardly in opposite directions and expand the collection bag.
Patent DE-68910464-T2 (DE)
Inventor: KJELDSEN MORTEN
IPC: H04M1/03
Filed: 1989-10-17
Granted: 1994-04-07
Abstract: The present invention relates to a telephone handset using an acoustic low impedance receiver transducer. A good reproduction of the low frequencies is obtained by introducing a front cover (7) having pure acoustic ohmic connections (8, 14) from the front side of the transducer diaphragm to the space (9) within the handset house (2).
Patent DE-68912343-T2 (DE)
Inventor: IVARSSON BENGT
IPC: G01N21/55
Filed: 1989-11-09
Granted: 1994-05-05
Abstract: PCT No. PCT/SE89/00641 Sec. 371 Date May 10, 1991 Sec. 102(e) Date May 10, 1991 PCT Filed Nov. 9, 1989 PCT Pub. No. WO90/05295 PCT Pub. Date May 17, 1990.An optical biosensor system using internal reflection versus angle of incidence determination for the detection of biomolecules, the system comprising a sensor unit (10) with at least two sensing surfaces (39A-D), a source of light (1), and lens means (2) for forming a convergent beam of light which is focused in wedge-shape fashion to form a streak of light (5) extending transversely over all the sensing surfaces; a photodetector device (7) in the form of a two-dimensional matrix of individual photodetector; optical imaging instrumentation in the form of an anamorphic lens system (6) for the purpose of imaging rays of reflected light from the sensing surfaces on each its own column of photodetectors, so that for each sensing surface there is a corresponding set of columns of photodetectors; and an evaluation unit (8) for determining the minimum reflectance or the resonance angle at each of the sensing surfaces. The invention also relates to a method for calibrating the biosensor system, a method for correcting for baseline drift as well as a method for temperature regulation of thermostat means in the biosensor system.
Patent DE-68920636-T2 (DE)
Inventor: BAILEY DOUGLAS J
IPC: E04B1/94
Filed: 1989-06-08
Granted: 1995-05-18
Abstract: A fire barrier material for use in building construction comprising a sandwich structure (1) have a first (2) and second (3) outer layers comprising a high temperature resistant material having corrugations (7, 9) therein and an intermediate layer (5) comprising a flame retardant fibrous material wherein the corrugation (7, 9) are positioned in the outer layers (2, 3) in a manner which enables the barrier material (1) to be rolled into a bundle in a direction substantially perpendicular to the direction of the corrugations (7, 9).
Patent DE-68926743-T2 (DE)
Inventor: ALAM RAFEUL
IPC: C07K14/52
Filed: 1989-01-11
Granted: 1997-01-09
Abstract: The present invention relates to a novel inhibitor of histamine release, designed HRIF which is believed to represent a promising therapeutic agent for treatment of basophil and mast cell dependent disorders, including allergic diseases. This inhibitor is a human cytokine that antagonizes a human histamine releasing cytokine(s) designated HRF. HRIF has a molecular weight of about 8,000 to 10,000 daltons as determined by gel exclusion chromatography and has also been purified by ion exchange chromatography. HRIF is stable when heated at 60 DEG C for one hour, when frozen and thawed four times, and when treated with neuraminidase. Treatment with trypsin or chymotrypsin substantially destroys the activity of HRIF. The present invention includes compositions comprising substantially purified HRIF as well as methods for HRIF production and use. The invention also includes HRIF-producing cell lines and methods for producing such cell lines.
Patent DE-68928545-T2 (DE)
Inventor: ROSENBERG STEVEN
IPC: C12N15/00
Filed: 1989-06-20
Granted: 1998-05-14
Abstract: The present invention provides recombinant polynucleotides which encode glucose oxidase (GO). It also provides recombinant expression systems which produce, and when desired, secrete active GO and GO analogs into the extracellular medium.
Patent DE-69002970-T2 (DE)
Inventor: BIRTWISTLE DAVID HOWARD
IPC: A61K8/46
Filed: 1990-02-16
Granted: 1994-01-13
Abstract: A shampoo composition comprises an anionic surfactant, a water-insoluble sunscreen, or mixtures thereof, and a cationic derivative of a polygalactomannan gum. When the sunscreen is normally solid at room temperature, then the composition further comprises a non-volatile solvent for the sunscreen.
Patent DE-69010232-T2 (DE)
Inventor: HINO KATSUHIKO
IPC: C07D221/04
Filed: 1990-02-20
Granted: 1994-12-01
Abstract: Novel 2-(1-piperazinyl)-4-phenyl-cycloalkanopyridine derivatives of the formula (I): <CHEM> wherein n is 3, 4, 5, 6 or 7; R<1> is hydrogen atom, C1-C10 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C6 cycloalkyl-(C1-C4) alkyl, hydroxy-(C2-C6) alkyl, C1-C3 alkoxy-(C2-C6) alkyl, acyloxy-(C2-C6) alkyl, unsubstituted or substituted aroyl-(C1-C6) alkyl, unsubstituted or substituted aryl, heteroaryl, or acyl; R<2> and R<3> are the same or different and are each hydrogen atom, halogen atom, C1-C6 alkyl, C1-C6 alkoxy, trifluoromethyl, or hydroxy; R<4>, R<5> and R<6> are the same or different and are each hydrogen atom, C1-C6 alkyl, or phenyl, or two of R<4>, R<5> and R<6> combine to form a single bond or C1-C3 alkylene; R<7> and R<8> are the same or different and are each hydrogen atom or C1-C3 alkyl; m is 2 or 3, or an acid addition salt thereof, which is useful as a psychotropic drug, and processes for the preparation thereof.
Patent DE-69023748-T2 (DE)
Inventor: MURRER BARRY ANTHONY
IPC: C07D257/02
Filed: 1990-12-19
Granted: 1996-05-02
Abstract: Pharmaceutical compositions containing as active ingredients a linked cyclic compound of the general formula I    Z - (A)n - Y (I)   in which Z and Y are independently polyheterocyclic moieties having from 9 to 32 ring members and from 3 to 8 amine heteroatoms, especially nitrogen, in the ring, A is a linking atom or group, and n is 0 or an integer from 1 to 6, are indicated for the treatment of viral infections, and preventative administration, especially for retroviral infections.
Patent DE-69026016-T2 (DE)
Inventor: GLUCHOWSKI CHARLES
IPC: A61P27/06
Filed: 1990-09-26
Granted: 1996-09-05
Abstract: The invention relates to the use of a compound of the formula (1):   <CHEM> and salts and mixtures thereof; wherein R1 is C1-3 alkyl, R2 is hydrogen or C1-5alkyl, n is 2 to 4, each x is independently 1 or 2, the hydrocarbon ring optionally including a double bond in a position other than the alpha-beta position; for the manufacture of a medicament for reducing or maintaining the intraocular pressure in a mammalian eye, e.g. for treating glaucoma.
Patent DE-69100116-T2 (DE)
Inventor: DE BRUIJNE DIRK WILLEM
IPC: A21D13/08
Filed: 1991-01-25
Granted: 1993-09-30
Abstract: A process is described for the preparation of laminated doughs, wherein the laminated dough has a number of fat layers having a different thickness. Such a dough is obtained by a process wherein the total amount of lamination fat is divided over several lamination steps. The invention is also concerned with a laminated dough, optionally in frozen condition and with baked products, obtained after baking of the dough.
Patent DE-69102156-T2 (DE)
Inventor: STERCHELE PAOLO
IPC: B65H63/032
Filed: 1991-01-31
Granted: 1994-09-08
Abstract: Device to check the presence of threads on spinning machines (11), which is fitted to a stationary ring rail (15) and cooperates with a traveller (18) set in rotation on a ring (16) by the thread (17), the device (10) at least governing an arresting and cutting means (21) and comprising a microphonic sensor (27) actuated by the shock waves due to the passage of the traveller (18). <IMAGE>
Patent DE-69108083-T2 (DE)
Inventor: MORIN RENE
IPC: F02M39/02
Filed: 1991-03-29
Granted: 1995-10-26
Abstract: The device comprises: a hub 1 forming one piece with the injection pump; a casing 2 rotationally driven, surrounding the hub 1 and comprising two rollers 4, 5 arranged parallel to the axis of the casing at a distance from this axis; an eccentric governor weight 15 fitted on the hub 1 so that it can travel in one direction under the action of centrifugal force; two advance control pistons 8, 9 with axis orthogonal to the axis of the hub, fitted in the said hub in such a way that they can each slide in a blind hole and each fitted with a lateral support plane 10, 11 capable of acting in concert with one of the said rollers 4, 5 in order to bring about an angular displacement between the hub 1 and the casing 2, one of the pistons 8 acting in the other direction on the governor weight 15 by way of a spring 18; a hydraulic circuit passing through the hub and comprising a controlled leak distributor 20 controlling the pressure acting on the pistons 8, 9 according to the position of the governor weight 15; and an additional piston 32 for modifying the balance position of the governor weight 15 according to the pressure prevailing in the hydraulic circuit. 
<??>Means of correction operating as a function of the temperature of the hydraulic fluid can also be provided. 
<IMAGE>
Patent DE-69108951-T2 (DE)
Inventor: LEVIEN RAPHAEL L
IPC: H04N1/405
Filed: 1991-02-06
Granted: 1995-10-05
Abstract: In the generation of screened halftones of photographic images for low resolution marking devices, conventional screen techniques are too coarse, and adaptive dither techniques are too fine. The present invention preserves the advantages of the adaptive dither techniques, while creating screen patterns with an adjustable degree of coarseness. The invention applies a hysteresis constant and recursion techniques previously limited to adaptive screening with fixed dot patterns to vary the size of dots in the screened image, thereby allowing adjustment of the image coarseness by adjusting the hysteresis constant. <IMAGE>
Patent DE-69109685-T2 (DE)
Inventor: OUTTRUP HELLE
IPC: C12N9/54
Filed: 1991-10-11
Granted: 1996-01-04
Abstract: PCT No. PCT/DK91/00309 Sec. 371 Date Feb. 22, 1993 Sec. 102(e) Date Feb. 22, 1993 PCT Filed Oct. 11, 1991 PCT Pub. No. WO92/07067 PCT Pub. Date Apr. 30, 1992.An alkaline protease isolated from a strain of Bacillus sp. J 20 is disclosed. The protease has a mass of about 29 kD, a pI of about 8.8, a pH optimum above 10, and a temperature optimum of about 45 DEG  to 65 DEG  C. The use of the protease as a detergent enzyme, as well as detergent compositions and detergent additives comprising the protease is also disclosed.
Patent DE-69119729-T2 (DE)
Inventor: JENKINSON CHRISTOPHER GRAHAM
IPC: G01R31/12
Filed: 1991-12-17
Granted: 1996-10-02
Abstract: A method of initiating and monitoring partial discharges in an insulating medium is disclosed. Apparatus for performing the method is also disclosed. A relatively low frequency time varying exciting waveform (20) is applied to a sample ( 14) of an insulating medium. A trigger pulse (22) of short duration is superimposed on the exciting waveform to initiate partial discharge activity in the sample. The apparatus includes a trigger pulse generator (16) with a synchronising circuit (26, 30, 32) which provides a pre trigger signal for an oscilloscope (18), allowing the resultant partial discharge activity to be monitored. <IMAGE>
Patent DE-69130223-T2 (DE)
Inventor: ROSER BRUCE
IPC: C12N9/96
Filed: 1991-05-14
Granted: 1999-08-26
Abstract: A method of preserving delicate biological substances or organic compounds (a) in a dry state and/or (b) at elevated temperatures and/or (c) under irradiation comprises incorporating in a system containing the said substances or compounds a sugar or a sugar derivative selected from (i) a non-reducing glycoside of a polyhydroxy compound selected from sugar alcohols and other straight chain polyalcohols, or (ii) a non-reducing oligosaccharide selected from raffinose, stachyose and melezitose.
Patent DE-69133558-T2 (DE)
Inventor: KHANDROS IGOR Y
IPC: H01L23/13
Filed: 1991-09-24
Granted: 2007-11-29
Abstract: A semiconductor chip assembly has a semiconductor chip (8420) having a front surface, the front surface including a central region and a peripheral region surrounding the central region, the chip having central contacts (8431) disposed in the central region of the front surface, a dielectric element (8436) overlying the chip front surface, and a plurality of terminals carried by the dielectric element for interconnection to a substrate. The dielectric element has a hole (8480) encompassing the central contacts, at least some of the terminals (8448) are central contact terminals overlying the chip front surface, and a plurality of central contact leads (8450) extend between the central contacts and the central contact terminals, the central contact leads being connected to the central contacts (8431) in the hole. <IMAGE>
Patent DE-69201723-T2 (DE)
Inventor: SOERENSEN JENS-RICHARD
IPC: F03D15/20
Filed: 1992-02-12
Granted: 1995-10-19
Abstract: PCT No. PCT/DK92/00044 Sec. 371 Date Jul. 1, 1993 Sec. 102(e) Date Jul. 1, 1993 PCT Filed Feb. 12, 1992 PCT Pub. No. WO92/14054 PCT Pub. Date Aug. 20, 1992.A wind-powered energy production and storing system comprises a wind rotor (1) in driving engagement with a power generator via transmission means, to which is also connected a heat pump for operation of at least one heat exchanger unit. The wind rotor (1) is designed as a wind wheel having a rim in direct driving engagement with a main shaft positioned in a subjacent engine housing (3) to which main shaft, in addition to the power generator and the heat pump, a dual circulation pump is coupled for conveying heated and cooled liquid, from a heating container and a cooling container, respectively, positioned in the engine housing (3) to separate heat and cold storing stations (16, 18). Via a steam separator (21) and a pumping device (22), a steam generator (17) may be connected to the heat storing station (16), which via a steam turbine (19) drives an additional power generator (20) for power production during periods of slack winds.
Patent DE-69203170-T2 (DE)
Inventor: PATTERSON THOMAS C
IPC: B23K15/08
Filed: 1992-07-21
Granted: 1995-11-02
Abstract: A frame that includes first and second tubular members (12, 14, 16, 18, 20) joined at a predetermined angle to each other solely by a bond along a joint between a surface along a portion of a wall of the first member (12, 18, 20) and an edge (14E, 16E, 18E) along at least a portion of the wall of the second member is fabricated by cutting the edge of the wall of the second member at the joint being to a shape that conforms to and abuts the surface of the first member so as to establish and maintain the predetermined angle between the members. The first member is formed with a slot (12S, 18S, 20S) that registers with the edge of the second member, and the second member is formed with an integral tab (14T, 16T, 18T) along part of the edge forming the joint. The tab on the second member is received in close-fitting relation in the slot of the first member so as to establish and maintain a predetermined position of the second member axially and rotationally relative to the first member. <IMAGE>
Patent DE-69218252-T2 (DE)
Inventor: MYERSON ALLAN
IPC: C22B7/00
Filed: 1992-11-10
Granted: 1997-09-18
Abstract: A method for the recovery of zinc oxide from industrial waste materials of various components, including zinc, lead, iron and cadmium, comprising the steps of treating the waste material with an ammonium chloride solution maintained at an elevated temperature, separating the undissolved components from the solution, treating the solution with zinc metal to displace undesired metal ions from the solution, cooling the solution to precipitate therefrom zinc compounds, washing the precipitated zinc compounds to remove unwanted compounds such as diamino zinc dichloride, and drying the remaining zinc compound which is essentially hydrated zinc oxide, resulting in essentially pure zinc oxide.
Patent DE-69225356-T2 (DE)
Inventor: MISHIMA SEIJI
IPC: H01S5/00
Filed: 1992-06-19
Granted: 1998-10-22
Abstract: A first light waveguide is formed, and second and third light waveguides are respectively connected to the first light waveguide at first and second positions. A first coupler for effecting light branching and/or combining is arranged near the first position, and a second coupler for effecting light branching and/or combining is arranged near the second position. An optical amplifier is arranged on the first light waveguide between the first and second positions for compensating for a light loss of a light wave caused by each of the first and second coupler. <IMAGE>
Patent DE-69227494-T2 (DE)
Inventor: CONDER MICHAEL J
IPC: C12R1/645
Filed: 1992-09-11
Granted: 1999-04-08
Abstract: (A) A novel process for preparing 7-aminodesacetoxy cephalsporanic acid (7-ADCA) is claimed comprising (a) maintaining in a culture medium capable of sustaining its growth, a strain of Penicillium chrysogenum (PC) which produces isopenicillin N (IPN) and adding to the culture medium an adipate feedstock comprising adipic acid or one or more of its salts and esters which are capable of being assimilated and utilised by the strain of PC to produce adipoyl-6-amino penicillanic acid (adipoyl-6-APA), where the strain of PC has been transformed by DNA encoding the activity of the expandase enzyme capable of accepting the adipoyl-6-APA as a substrate so that as a result of its expression, the adipoyl-6-APA produced by the strain is in situ ring expanded to form adipoyl-7-ADCA and (b) contacting the adipoyl-7-ADCA with an adipoyl cyclase whereby the adipoyl side chain is removed and 7-ADCA is formed which is then isolated. Also claimed are: (B) a recombinant DNA expression vector comprising DNA encoding the activity of the expandase enzyme derived from Streptomyces clavuligerus (S.C) ATCC 27064 and a promoter which drives expression of the expandase activity-encoding DNA comprising the promoter of the PC IPN synthetic (IPNS) gene; (C) a PC host cell transformed with a recombinant DNA expression vector as in (B).
Patent DE-69228127-T2 (DE)
Inventor: GAGE FRED
IPC: C12N15/12
Filed: 1992-11-13
Granted: 1999-09-02
Abstract: Methods of genetically modifying donor cells by gene transfer for grafting into the central nervous system to treat defective, diseased or damaged cells are disclosed. The modified donor cells produce functional molecules that effect the recovery or improved function of cells in the CNS. Methods and vectors for carrying out gene transfer and grafting are described.
Patent DE-69228922-T2 (DE)
Inventor: LIM RICHARD M
IPC: A61K6/884
Filed: 1992-12-18
Granted: 1999-08-26
Abstract: A composition containing a water soluble or water swellable polyelectrolyte or salts thereof in a dentifrice base or other oral compositions which can be used for relieving pain and discomfort caused by hypersensitive teeth. The salts can be single or mixed partial salts of the polyelectrolyte.
Patent DE-69309230-T2 (DE)
Inventor: BUSSINI GIUSEPPE
IPC: D06F37/42
Filed: 1993-11-26
Granted: 1998-01-02
Abstract: The safety door lock structure particularly for washing machines with built-in electronic system is provided with an electromechanical device (2) which is contained in a containment body which can be associated with the cabinet of the washing machine; the device includes a power microswitch (5) for starting the washing machine and an electromagnet (6) connected to a mechanical means (7) for blocking and releasing the door (12) of the washing machine; the means has a first slider member (8) and a second slider member (9) which are activated, in contrast with, and by virtue of, the action of a first elastic means (10), both by the door to automatically block it in closed position and by the electromagnet to instantly release the door from the closed position to an open position. <IMAGE>
Patent DE-69314746-T2 (DE)
Inventor: NARDIZ LANDA ISIDRO
IPC: B61F3/16
Filed: 1993-05-07
Granted: 1998-05-20
Abstract: Bogies for railway vehicles with variable gap between wheels, consisting of a center frame (1), to which four oscillating arms are united by means of relative joints (2), at each of which ends bearing boxes for each rolling assemblies (3) are housed, which can be transversely moved, the wheel being located in each of two positions corresponding to two gauges, relying on the fact that the opposed portion of each arm rests on a helical spring (4), the lower end of which is resting on the center frame bottom, and at the end of this portion there is mounted a vertical shock absorber (5). <IMAGE>