Patent SG-11201906791U-A (SG)
Title: Rorgamma modulators and uses thereof
Inventor: DELHOMEL JEAN-FRANÇOIS
IPC: C07D295/185
Filed: 2018-01-29
Abstract: International Patent Classification: C07D 295/185 (2006.01) A61K 31/4427 (2006.01) CO7D 405/12 (2006.01) A61P 37/02 (2006.01) CO7D 295/155 (2006.01) A61P 29/00 (2006.01) A61K 31/496 (2006.01) A61P 3/00 (2006.01) (21) International Application Number: PCT/EP2018/052161 (22) International Filing Date: 29 January 2018 (29.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17305090.7 27 January 2017 (27.01.2017) EP (71) Applicant: GENFIT [FR/FR]; 885 avenue Eugene Avinee, 59120 LOOS (FR). (72) Inventors: DELHOMEL, Jean-Francois; 79 avenue du President JF Kennedy, 62000 ARRAS (FR). PERSPI- CACE, Enrico; 1 me Maurice Schumann, 59133 PHALEMPIN (FR). MAJD, Zouher; 29 rue Nationale, 59320 ENNETIERES-EN-WEPPES (FR). PARROCHE, Peggy; 9 rue des Brigittines, 59800 LILLE (FR). WAL- CZAK, Robert; Residence Parc d'Isly, 13B rue Delezenne, 59000 LILLE (FR). BONNET, Pascal; 349 Allee des Per- venches, 45160 OLIVET (FR). FOGHA, Jade; 45 me des Hauts Champs, 45000 ORLEANS (FR). (74) Agent: CABINET BECKER ET ASSOCIES; 25, me Louis le Grand, 75002 PARIS (FR). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) Rid Ric RIa = (54) Title: RORGAMMA MODULATORS AND USES THEREOF R1 e R 4 00 R1 b (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 02 August 2018 (02.08.2018) WIP0 I PCT ill~~~~~~~~ 011101010VIIIOH olo um °um oil voimiflo oimIE (10) International Publication Number WO 2018/138354 Al (la) (57) : The present invention provides novel compounds of formula (la) that are modulators of RORgamma. These compounds, el and pharmaceutical compositions comprising the same, are suitable means for treating any disease wherein the modulation of RORgam- ma has therapeutic effects, for instance in autoimmune diseases, autoimmune-related diseases, inflammatory diseases, metabolic dis- eases,, fibrotic diseases, or cholestatic diseases. (formula Ia)