baber/WOPTO huggingface dataset:
Patent PL-2143795-T3 (PL)
Title: Anti-CD20 monoclonal antibody
Inventor: NUMAZAKI MASANORI
IPC: A61P29/00
Filed: 2006-03-31
Abstract: Disclosed is a monoclonal antibody capable of inducing a specific biological reaction through the binding of the monoclonal antibody to a CD20 antigen on the surface of a cell. A monoclonal antibody having a high binding affinity to an extracellular epitope of a CD20 antigen and also having biological activities including a cell growth inhibitory activity is cloned. The monoclonal antibody is chimerized or humanized to develop a therapeutic agent for a disease in which B cells are involved.
Patent PL-2431063-T3 (PL)
Title: Decellularization and recellularization of organs and tissues
Inventor: TAYLOR DORRIS A
IPC: C12N5/077
Filed: 2006-08-28
Abstract: The invention provides for methods and materials to decellularize a solid organ and to recellularize such a decellularized organ to thereby generate a solid organ.
Patent GR-3000757-T3 (GR)
Title: Child-proof threaded closure
Inventor: SCHICK JURGEN
IPC: B65D55/02
Filed: 1990-09-06
Abstract: The present invention provides a non-strippable, child-proof screw closure for containers, and especially for storage bottles containing cleaning liquids, comprising a pourer arranged on the container having external threads and radially extending stops formed thereon, and a screw cap with catches which can be opened out by the stops. The screw cap has a separate internal threaded piece.
Patent GR-3001710-T3 (GR)
Title: Pharmaceutical formulation and process for its preparation
Inventor: LIST PAUL H
IPC: A61K9/10
Filed: 1991-04-02
Abstract: A pharmaceutical formulation for the parenteral, in particular intravenous, administration of sparingly soluble substances is obtained when the very finely ground substance, with a maximum particle diameter of 3  mu m, is dispersed in an oil phase which contains emulsifier, and this mixture is emulsified with water for injection, is rendered isotonic and is homogenized using a high-pressure homogenizer, so that the resultant product is a solid/liquid/liquid disperse system.
Patent GR-3002692-T3 (GR)
Title: Benzoxazine derivatives and processes for preparation thereof
Inventor: IIJIMA IKUO
IPC: C07D417/06
Filed: 1991-09-12
Abstract: Novel benzoxazine derivative of the formula: <CHEM> wherein R<1> is phenyl group or a substituted thiazolyl group; R<2> is hydrogen atom or a lower alkyl group; Q is single bond or a lower alkylene group, or a salt thereof are disclosed. Said derivative (I) and a salt thereof are useful as therapeutic agents for diabetes.
Patent GR-3003435-T3 (GR)
Title: Vaginal contraceptive
Inventor: CHANTLER ERIC N
IPC: A61K9/00
Filed: 1991-12-24
Abstract: The present invention relates to a vaginal contraceptive, particularly a diaphragm, containing two or more drugs. According to the invention the contraceptive is impregnated with a mixture of at least two different spermicides in water. Usually one spermicide is a non-ionic detergent of the alkyl phenol ethoxylate type, whereas the other is a biguanide with antiseptic properties. The non-ionic detergent is, preferably, nonoxynol-9 and the biguanide chlorohexidine gluconate. Very good results are obtained when the vaginal contraceptive according to the invention is impregnated with a mixture of spermicides, containing 10-15% vol./vol. of nonoxynol-9, 0.5-1.5% by weight/vol. of chlorohexidine gluconate, the balance being water. Finally, the invention relates to a vaginal contraceptive which is liquid tight packed in the mixture as defined before.
Patent GR-3005138-T3 (GR)
IPC: A61K47/06
Filed: 1992-07-10
Abstract: This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said systemic agent an effective amount of a membrane penetration enhancer having the structural formula <CHEM> wherein each X, Y and Z may represent oxygen, sulfur or two hydrogen atoms, provided however that, when Z represents two hydrogen atoms, both X and Y represent oxygen or sulfur and when Z represents oxygen or sulfur at least one of X and Y must represent oxygen or sulfur; m is 2-6; R' is H or a lower alkyl group having 1-4 carbon atoms; n is 0-16 and R is -CH3, <CHEM> wherein R'' is H or halogen. y
Patent GR-3006701-T3 (GR)
IPC: B04B1/20
Filed: 1992-12-30
Abstract: A decanter centrifuge which includes an annular bowl (7), a hollow tube (20) on the axis of the bowl, and means (23) for discharging from the bowl a first phase of an input sludge (15), the centrifuge being characterised by a fluid-activated airlift device (27) which includes a discharge line (30) radially supported from the hollow tube, and a fluid supply line (28, 28A) for conveying fluid from within the hollow tube to an outer end portion of the discharge line to effect removal from the bowl through said line of another phase of the sludge.
Patent GR-3015701-T3 (GR)
Title: Telecommunication and management terminal connectable to the telephone network and an automatic calling device for such a terminal.
Inventor: GUICHARD JEAN-PIERRE
IPC: H04M11/00
Filed: 1995-04-06
Abstract: The terminal, usable in particular for the remote reading of meters, permits alternate use of at least one public network telephone line for voice communications to and from at least one local telephone set and for transfers of data, comprising an automatic electronic switch having at least one line unit connectable to a network line and internal line junctions units for linking with at least one local subscriber set. It comprises: means reacting to any incoming call stream in order to engage the line (LR) and send back a vocal enquiry message, of determined period; and means (32, 36) for recognising at least one predetermined access code coming in during the said determined period and for directing the call towards the local set whilst causing local ringing in the event of absence of recognised access code, or towards another communication peripheral in the event of recognition of the predetermined access code specific to the said other peripheral. <IMAGE>
Patent GR-3017181-T3 (GR)
Title: Process for production of bishomo-gamma-linolenic acid.
Inventor: AKIMOTO KENGO
IPC: C12R1/80
Filed: 1995-08-23
Abstract: A process for the production of bishomo- gamma -linolenic acid characterized by adding an additive to a culture medium, which additive is preferably selected from sesame oil, peanut oil, an extract from sesame oil or sesame seeds, and a lignan compound present in the extract from sesame oil or sesame seeds. The process uses, as a producer microorganism, a microorganism capable of producing arachidonic acid.
Patent GR-3018028-T3 (GR)
Title: Device for dehiding animals, in particular goats and sheep.
Inventor: LOEUL FREDERIC
IPC: A22B5/16
Filed: 1995-11-08
Abstract: Device for dehiding (skinning) animals, in particular sheep and goats any of whose horns and hooves have previously been cut off, characterised in that it comprises a framework (10), a first animal conveyor (18) comprising means for attachment of these animals and located at a fixed height and a second conveyor (20), parallel over at least a part of its length with the first conveyor and synchronous therewith, driving vertical elements (38) on which means (16) for gripping the hide (skin) of the animals are mounted movably in translation. <IMAGE>
Patent GR-3019631-T3 (GR)
Title: Microbicidal agents
Inventor: STECK BERNHARD
IPC: A01N25/04
Filed: 1996-04-11
Abstract: The combination of the plant microbicide 4-(2,2-difluoro-1,3-benzodioxol-7-yl)-1H-pyrrole-3-carbonitril with the plant microbicide  alpha -[2-(4-chlorophenyl)ethyl]- alpha -(1,1-dimethyl-ethyl)- beta -(1H-1,2,4-triazolyl)-1-ethanol results in a synergistically enhanced effect in the control of plant diseases. Microbicidal compositions based on such combinations are suitable for treating natural products of vegetable and animal origin and, in particular, for seed treatment.
Patent GR-3019587-T3 (GR)
Title: N-trityl aspartic acid derivatives for preparing phosphonate nmda antagonists.
Inventor: WHITTEN JEFFREY P
IPC: A61K31/66
Filed: 1996-04-09
Abstract: The present invention related to novel (R)-dimethyl N-tritylaspartate and novel (R)-alkyl N-trityl-4-oxo-5-phosphononorvalinate derivatives which are useful in the preparation of the class of beta-ketophosphonate NMDA antagonists.
Patent GR-3020338-T3 (GR)
Title: Self-propelled cleaning device,particularly for swimming pools
Inventor: SOMMER PETER
IPC: E04H4/16
Filed: 1996-06-27
Abstract: In an automobile cleaning device, particularly for swimming pools, a drive (9) for the cleaning device is integrated in a base housing (1) and at least one cleaning brush (21) and a suction channel (29) are provided. The liquid to be cleaned is conveyed through this suction channel (29) by means of a pump (40) into a filtering space (35). In this arrangement, this filtering space (35) extends over almost the entire upper side of the base housing (1) and is covered by a housing lid (41). 
<IMAGE>
Patent GR-3023768-T3 (GR)
Title: Inhibitor for blood vessel hypertrophy.
Inventor: SEKI JIRO
IPC: A61K31/16
Filed: 1997-06-12
Abstract: An inhibitor for blood vessel hypertrophy containing a compound represented by formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient and having an excellent drug efficacy. <CHEM>
Patent GR-3031054-T3 (GR)
Title: Methods for stable transformation of wheat.
Inventor: CHANG YIN-FU
IPC: C12M3/00
Filed: 1999-08-23
Abstract: The present invention is drawn to the production of fertile transformed wheat plants. The method involved subjecting wheat tissues to high velocity microprojectile bombardment, selecting for transformed cells, and regenerating stably transformed fertile plants from the transformed cells.
Patent GR-3034186-T3 (GR)
Title: 3,4-diarylchromans for treatment of dermatitis
Inventor: PIGGOTT JAMES R
IPC: A61K31/352
Filed: 2000-08-14
Abstract: Methods for the treatment of dermatitis are disclosed wherein 3,4-diarylchromans and their pharmaceutically acceptable salts are formulated into medicaments, including oral and topical medicaments, and are administered to a patient suffering from dermatitis.
Patent GR-3035496-T3 (GR)
Title: Gulley-grid
Inventor: HAUER JEAN-CLAUDE
IPC: E02D29/14
Filed: 2001-03-01
Abstract: The grating (1) comprises a frame (2) with a support surface (6) and on the periphery a ratchet point (8). A removable rigid cover (3) on the support surface has a springy bar (15) whose free end (16), located on the cover edge, mates with the ratchet point. The springy bar forms an angle of 60 degrees with the adjacent periphery of the cover, while its free end is framed by the rigid cover edge (12). The ratchet point and the free end of the bar each have a double ramp for locking and unlocking. The cover has a slot (18) in a location spaced from the bar, for the introduction of a tool for tipping the cover about a peripheral zone parallel to the bar. <IMAGE>
Patent GR-3036078-T3 (GR)
Title: Novel niddm regimen
Inventor: HEMMINGSEN LISBETH TOFTE
IPC: A61K31/451
Filed: 2001-06-19
Abstract: The present invention relates to a method of achieving significant improvement in the glycaemic control by the combined use of a short-acting hypoglycemic agent, such as repaglinide, and metformin in NIDDM patients poorly controlled on metformin alone.
Patent DK-0885244-T4 (DK)
Inventor: KRICEK FRANZ
IPC: C12N15/09
Filed: 1997-02-28
Granted: 2008-06-16
Abstract: Disclosed are compositions for treating allergies that include either BSW17 mimotope peptides or antibodies raised against BSW17 mimotope peptides. Also disclosed are methods for the treatment of allergies which involve administration of BSW17 mimotope peptides or the administration of antibodies raised against BSW17 mimotope peptides.
Patent TR-201803021-T4 (TR)
Title: Rölyef dekorasyonların kalınlığını arttırmak için yöntem ve cihaz, yüzeylerin rölyef dekorasyonu için proses ve tesis.
Inventor: GILBERTO MENIN
IPC: D06Q1/10
Filed: 2010-09-24
Abstract: Rölyef dekorasyonlarının kalınlığının arttırılmasının bir yöntemi şu adımları içermektedir: rölyefin en az bir kısmının, söz konusu nesnenin(3) bir dekore edilmiş yüzeyi (2) üzerine yerleştirilmiş bir dekoratif termoplastik veya termoyapışkan malzemeden (4) yapıldığı bir dekore edilmiş nesnenin (3) sağlanması; yapışkan hale getirene kadar dekore edilmiş yüzeye(4) uygulanan dekoratif termoplastik veya termoyapışkan malzeme (4)kısmının ısıtılması; söz konusu tozlaştırılmış malzemenin (22), dekoratif termoplastik veya termoyapışkan malzemenin (4) kısmına yapıştığı, dekore edilmiş yüzey (2) üzerine bir tozlaştırılmış malzemenin (22) yayılması; burada üçüncü adım, nesnenin (3) tozlaştırılmış malzeme (22) içinden basınç altında bir basıncın uygulanması ile üretilen bir sıvı yatağına en az bir kere daldırılması ile gerçekleştirilmektedir.
Patent TR-201818474-T4 (TR)
Title: Eklentiler, Eklentiler Ve Oligomerler Veya Eklentiler, Oligomerler Ve Düşük Molekül Ağırlıklı Polimerler Ve Bunların Hazırlanması
Inventor: WILLIAM J JR LAYMAN
IPC: C08K5/00
Filed: 2008-06-06
Abstract: Buluş monovinilaromatik hidrokarbonlardan oluşan eklentiler, eklentiler ve oligomerlerin karışımları ve/veya eklentiler, oligomerler ve düşük molekül ağırlıklı polimerlerin karışımlarını sunmaktadır.
Patent TR-201818984-T4 (TR)
Title: İklimlendirme Cihazı
Inventor: YOSHIYUKI TSUJI
IPC: F24F11/89
Filed: 2015-12-07
Abstract: İklimlendirme aparatının (1) kumandası (8), iklimlendirme işlemi gerçekleştiren tüm iç ünitelerde (4a, 4b, 4c) her iç sıcaklık, iklimlendirme işlemi gerçekleştiren her iç ünitedeki (4a, 4b, 4c) hedef iç sıcaklığı çevreleyen önceden belirlenmiş eşik sıcaklık aralığı kapsamında olduğunda iklimlendirme kapasitesinde artış talep eden iç ünitelerdeki talep değerlerini göz ardı ederek kompresör (21) dönüş hızının iklimlendirme (5) kapasitesinde azalma talep eden iç ünitelerdeki talep değerlerine dayalı kontrol edildiği bir başlatma/durdurma sıklığı azaltıcı dönme hızı kontrolü gerçekleştirir.
Patent TR-201904555-T4 (TR)
Title: Dokunmamış malzeme ve gerilebilir laminat.
Inventor: KIOSHI KUNIHIRO
IPC: D04H5/08
Filed: 2013-11-08
Abstract: Hem makine doğrultusunda hem de çapraz doğrultuda mükemmel gerilebilirliğe sahip olan dokunmamış malzemeler ve bu dokunmamış malzemeleri içeren laminatlar. Dokunmamış malzeme, bir çekirdek kısım ve bir kılıf kısmı içeren bir kılıf-içi-çekirdek yapısına sahip liflerden oluşur. Çekirdek kısım bir termoplastik elastomer içerir. Kılıf kısmı, 100 g/10 dakikaya eşit veya daha yüksek bir eriyik akış hızına ve 220 °C ile 260 °C arasındaki bir sıcaklık aralığında seçilen belirli bir sıcaklıkta termoplastik elastomerden daha düşük bir viskoziteye sahip bir poliolefin içerir.
Patent TR-201908766-T4 (TR)
Title: Egzos gazı resirkülasyonu için tertibat ve yöntem.
Inventor: Tobias winter
IPC: F01P5/10
Filed: 2016-05-06
Abstract: Özellikle de dizel motorlarında, egzos gazı hattından motorun temiz hava yolu içerisine egzos gazı resirkülasyonu (AGR) için tertibat olup, burada bir egzos gazı resirkülasyon (AGR) yolu içerisinde motorun soğutma sistemine bağlanmış bir soğutma tertibatı, egzos gazı (AG)-soğutma maddesi ısı eşanjörü olarak öngörülmüştür, buna, egzos gazı (AG) resirkülasyon hızının ölçülmesi için, bir soğutma maddesine bağlanmış bir egzos gazı resirkülasyon (AGR) valfı (6) tahsis edilmiştir, burada soğutma tertibatı, bir egzos gazı (AG) ön soğutucuyu (3) ve bunun arkasına bağlanmış bir egzos gazı (AG) ana soğutucuyu (5) kapsar, ve egzos gazı resirkülasyon (AGR) valfı (6), egzos gazı (AG) ön soğutucu ve egzos gazı (AG) ana soğutucu arasında düzenlenmiş bir valf muhafazasının (4) içerisine yerleştirilmiştir.
Patent TR-201910194-T4 (TR)
Title: Hibrit ısı eşanjör aparatı ve bunun işletme metotları.
Inventor: III W THOMAS BUGLER
IPC: F28B5/00
Filed: 2011-07-11
Abstract: Mevcut buluş bir hibrit ısı eşanjörü aparatı ile ilgilidir. Daha özel olarak, mevcut buluş, suyu korumak ve, imkan dahilinde, buhar emisyonunu azaltmak için, bir kuru modda, bir ıslak modda ve bir hibrit modda çalışan bir hibrit ısı eşanjörü aparatına yöneliktir.
Patent DE-10296810-T5 (DE)
Title: Laserstrahlpositionierungsvorrichtung für Laserbearbeitungsausrüstung
Inventor: IWATA TAKAAKI
IPC: B23K26/00
Filed: 2002-03-26
Abstract: Laserstrahlpositionierungsvorrichtung für eine Laserbearbeitungsausrüstung, umfassend:  eine Plattform, wo ein Werkstück platziert wird;  einen Laseroszillator, der einen Laserstrahl emittiert;  eine optische Einheit, die den Laserstrahl lenkt, sodass der Laserstrahl das Werkstück bestrahlt, das auf der Plattform platziert ist;  eine Strahlenabtasteinheit, die den Laserstrahl abtastet, der durch das optische Mittel gelenkt wird;  eine Messeinheit, die eine bearbeitete Position auf dem Werkstück misst, in der die Laserbearbeitung durchgeführt wurde; und  eine Steuereinheit, die den Befehlswert von Koordinaten der bearbeiteten Position und Koordinaten einer Zielposition kalkuliert, wobei  die Steuereinheit eine Matrix unbekannter Parameter durch Gewichtung der Koordinaten der bearbeiteten Position und des Befehlswerts gemäß einem Abstand zwischen den Koordinaten der Zielposition und den Koordinaten der bearbeiteten Position kalkuliert, wobei die Matrix unbekannter Parameter den Befehlswert optimal bestimmt, um den Laserstrahl auf die Zielposition auf dem Werkstück zu lenken.
Patent DE-10296983-T5 (DE)
Title: Zusammengesetzter Sensor für das Detektieren einer Winkelgeschwindigkeit und einer Beschleunigung
Inventor: MITANI TOMOHIRO
IPC: G01C19/5663
Filed: 2002-06-24
Abstract: Komplexer Sensor für das Detektieren einer Winkelgeschwindigkeit und einer Beschleunigung, umfassend:  eine Winkelgeschwindigkeitsdetektionsvorrichtung für das Detektieren der Winkelgeschwindigkeit, wobei die Vorrichtung einen Leistungsversorgungsanschluss, einen Erdanschluss und einen Winkelgeschwindigkeitsausgabeanschluss einschließt;  eine Beschleunigungsdetektionsvorrichtung für das Detektieren einer Beschleunigung, wobei die Vorrichtung einen Leistungsversorgungsanschluss, einen Erdanschluss und einen Beschleunigungsausgabeanschluss einschließt, und  eine Leiterplatte, die mit einer Verarbeitungsschaltung versehen ist, für das Verarbeiten des Winkelgeschwindigkeitssignals, das vom Winkelgeschwindigkeitsausgabeanschluss der Winkelgeschwindigkeitsdetektionsvorrichtung geliefert wird, und eines Beschleunigungssignals, das vom Beschleunigungsausgabeanschluss der Beschleunigungsdetektionsvorrichtung geliefert wird, wobei die Winkelgeschwindigkeitsdetektionsvorrichtung und die Beschleunigungsdetektionsvorrichtung auf der Leiterplatte angeordnet sind.
Patent DE-10297589-T5 (DE)
Title: Vorschaltgerät für Entladungslampe
Inventor: MITSUYASU KEI
IPC: H05B41/392
Filed: 2002-12-26
Abstract: Vorschaltgerät für eine Entladungslampe,
umfassend:  eine DC-Spannungsquelle, welche eine Eingangsspannung
empfängt
und eine geregelte DC-Ausgangsspannung bereitstellt, wobei die DC-Spannungsquelle
ein Schaltelement umfasst, welches angesteuert wird, um auf eine
gesteuerte Weise ein- und ausgeschaltet zu werden, um die DC-Ausgangsspannung
bereitzustellen,  eine Inverterschaltung, welche die DC-Ausgangsspannung in
eine Hochfrequenzspannung umwandelt, wobei die Inverterschaltung
wenigstens ein Paar von zwei Schaltelementen umfasst, welche über die
DC-Ausgangsspannung in Reihe geschaltet sind und so gesteuert werden,
dass sie abwechselnd ein- und ausgeschaltet werden, um die Hochfrequenzspannung
bereitzustellen, einen Lastkreis, welcher die Hochfrequenzspannung
empfängt,
um sie an die Entladungslampe anzulegen, um die Entladungslampe
anzusteuern;  eine integrierte Steuerschaltung, welche die Schaltelemente
der DC-Spannungsquelle,
sowie der Inverterschaltung steuert;  wobei die integrierte
Steuerschaltung umfasst:  eine erste Steuereinheit, welche ein
erstes Steuersignal zur Steuerung des Schaltelements der DC-Spannungsquelle erzeugt;   eine
zweite...
Patent DE-10394302-T5 (DE)
Title: Roboter-Steuersystem
Inventor: TAKAHASHI HIROKI
IPC: B25J19/00
Filed: 2003-10-10
Abstract: Roboter-Steuersystems,
bei welchem vorgesehen sind:  ein bewegbares Bewegungsteil;  ein
Motor zum Antrieb des Bewegungsteils;  eine Positionsdetektorvorrichtung
zur Feststellung der Position des Motors und zur Erzeugung eines
Positionsdetektorsignals;  ein Anschlag zur Begrenzung der Bewegung
des Bewegungsteils;  eine Bremse zum Sperren und Freigeben der
Verschwenkung des Motors;  eine Steuereinheit zum Antrieb des
Motors;  eine Befehlsvorrichtung, um die Steuereinheit außer Betrieb
zu setzen, und zum Freigeben der Bremse; und  eine erste Bremssteuervorrichtung,
zum Variieren, durch den Betrieb der Befehlsvorrichtung, der Dauer
des Sperrens oder der Freigabe der Bremse, auf Grundlage der Entfernung
zwischen dem Anschlag und dem Bewegungsteil.
Patent ES-2274815-T5 (ES)
Inventor: JOHNSTON SIMON RICHARD
IPC: C02F1/00
Filed: 2000-12-20
Granted: 2011-03-31
Abstract: Appliance has relatively high power heating for boiling water, and low power heater to maintain it at boiling point. Steam sensitive control (140) switches appliance from high to low power, and second steam sensitive control (142) maintains temperature at boiling point for a minute or more so as to ensure adequate sterilization of water before switching off. Lid (114) of the appliance is fitted with removable charcoal filter cartridge (116). An independent claim includes a steam passage for the water heating appliance.
Patent ES-2274817-T5 (ES)
Inventor: CLARK ANDREW
IPC: B05B11/06
Filed: 2000-12-15
Granted: 2010-12-03
Abstract: An apparatus (134) for aerosolizing a powdered medicament, comprising: 
a housing (136) having a holder (138) that is adapted to receive a receptacle (140) having a cavity that holds a powder; 
a piercing mechanism that is adapted to pierce a hole in a bottom end of the receptacle (140); 
a vent forming mechanism for forming multiple vents (126) in a top end of the receptacle (140); and 
an extraction tube (144) that is adapted to be placed into the cavity so as to be spaced above the bottom end of the receptacle (140) and to be aligned with the hole in the bottom end.
Patent ES-2333425-T5 (ES)
Inventor: FALLAUX FRITS JACOBUS
IPC: C12N5/08
Filed: 1996-06-14
Granted: 2012-08-28
Abstract: The invention provides improved methods and products based on adenoviral materials which can advantageously be used in for instance gene therapy. In one aspect an adenoviral vector is provided which has no overlap with a suitable packaging cell line which is another aspect of the invention. This combination excludes the possibility of homologous recombination, thereby excluding the possibility of the formation of replication competent adenovirus. In another aspect an adenovirus based helper construct which by its size is incapable of being encapsidated. This helper virus can be transferred into any suitable host cell making it a packaging cell. Further a number of useful mutations to adenoviral based materials and combinations of such mutations are disclosed, which all have in common the safety of the methods and the products, in particular avoiding the production of replication competent adenovirus and/or interference with the immune system. Further a method of intracellular amplification is provided.