Patent SG-11201804575Q-A (SG)
Title: Devices, methods, and compositions for restricting cell position and stabilizing cells in culture systems
Inventor: HAJIPOURAN BENAM KAMBEZ
IPC: G01N33/53
Filed: 2016-12-02
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau ..... .....) (43) International Publication Date r ... 6 July 2017 (06.07.2017) WI P0 I P CT ID Hit (10) WO International 2017/116608 111111111111111111111111111111111111111111111111111111111111R111111111111111 Publication Number A3 (51) International Patent Classification: (74) Agents: RESNICK, David, S. et al.; Nixon Peabody LLP, C12M 1/36 (2006.01) C12Q 3/00 (2006.01) 70 W. Madison St., Suite 3500, Chicago, Illinois 60602- C12M 3/00 (2006.01) G01N 33/53 (2006.01) 4224 (US). C12M 3/04 (2006.01) (81) Designated States (unless otherwise indicated, for every (21) International Application Number: kind of national protection available): AE, AG, AL, AM, PCT/US2016/064647 AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (22) International Filing Date: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, 2 December 2016 (02.12.2016) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, (25) Filing Language: English KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (26) Publication Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (30) Priority Data: SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, 62/263,383 4 December 2015 (04.12.2015) US TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, 62/333,007 6 May 2016 (06.05.2016) US ZW. (71) Applicant: PRESIDENT AND FELLOWS OF HAR- (84) Designated States (unless otherwise indicated, for every YARD COLLEGE [US/US]; 17 Quincy Street, Cam- kind of regional protection available): ARIPO (BW, GH, bridge, Massachusetts 02138 (US). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (72) Inventors: HAJIPOURAN BENAM, Kambez; 3 Pe- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, abody Terrace, Apt. 21, Cambridge, Massachusetts 02138 DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Richard; 42 Rockview 4, (US). NOVAK, Street, Unit Ja- LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, maica Plain, Massachusetts 02130 (US). INGBER, Don- SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, ald, E.; 162 W. Canton St., Boston, Massachusetts 02118 GW, KM, ML, MR, NE, SN, TD, TG). (US). [Continued on next page] (54) Title: DEVICES, METHODS, AND COMPOSITIONS FOR RESTRICTING CELL POSITION AND STABILIZING CELLS IN CULTURE SYSTEMS : A device is directed to function tissue, (57) simulating a of a and / 100 includes a first structure defming a first chamber, a second structure defining 116 118 Pi 102 a second chamber, and a porous membrane located at an interface region between the first chamber and the second chamber. The membrane has a first side facing toward the first chamber and a second side facing toward the the the first from the second chamber, membrane separating chamber second chamber. The first side includes a fluid-permeable, stimulus-responsive 108 polymer gel thereon, the second side including at least one layer of cells ad - 106 hered thereon. 112 104 110 114 FIG. IA 100 en .4t cc 104 1-1 Ir---- 11 C ei H J 1 111 — 112 106 118 116 FIG. IB 102 108 110 O WO 2017/116608 A3 IDEDIMOREIDIIMIDEEEHHHIMIIMEMEMON Declarations under Rule 4.17: — before the expiration of the time limit for amending the — as to applicant's entitlement to apply for and be granted a patent (Rule 4.1 7(ii)) claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — as to the applicant's entitlement to claim the priority of (88) Date of publication of the international search report: the earlier application (Rule 4.1 7(iii)) 14 September 2017 Published: — with international search report (Art. 21(3))