baber/WOPTO huggingface dataset:
Patent CA-2302992-C (CA)
Title: Methods for generating high titer helper-free preparations of recombinant aav vectors
Inventor: ATKINSON EDWARD MORROW
IPC: C12N15/09
Filed: 1998-09-04
Granted: 2011-11-01
Abstract: This invention provides methods and compositions for producing high titer, substantially purified preparations of recombinant adeno-associated virus (AAV) that can be used as vectors for gene delivery. At the onset of vector production, AAV producer cells of this invention typically comprise one or more AAV packaging genes, an AAV vector comprising a heterelogous (i.e. non-AAV) transgene of interest, and a helper virus such as an adenovirus. The AAV  vector preparations produced are generally replication incompetent but are capable of mediating delivery of a transgene of interest (such as a therapeutic gene) to any of a wide variety of tissues and cells. The AAV  vector preparations produced according to this invention are also substantially free of helper virus as well as helper viral and cellular proteins and other contaminants. Also provided is a quantitative, high-throughput assay useful in the assessment of viral infectivity and replication, as well as in the screening of agents that affect viral infectivity and/or replication.
Patent CA-2306236-C (CA)
Inventor: NEBULONI LUIGI
IPC: G01N35/02
Filed: 2000-04-19
Granted: 2010-07-06
Abstract: The present invention relates to photometric analysis apparatus of the type which uses disk-shaped rotors, in which the rotors are loaded automatically. In particular, the present invention relates to photometric analysis apparatus of the type which uses disk-shaped rotors, characterized in that it has a device for loading the rotors (3) onto analysis apparatus (5) automatically, the device comprising a hopper (2) for supplying the rotors, the hopper (2) comprising asymmetric means for locating the rotors (3) positively in the hopper.
Patent CA-2310653-C (CA)
Title: Container and cartridge for dispensing paper products
Inventor: TRAMONTINA PAUL FRANCIS
IPC: B65D83/08
Filed: 1998-12-15
Granted: 2005-08-02
Abstract: A container (10) for dispensing individual paper products (12), the container includes a housing (14) including a plurality of exterior walls defining an interior surface (30) and an interior area (28) within the interior surface (30) for receiving a plurality of the paper products (12). A first end wall (40) defines a dispensing throat (32) for permitting removal of paper products (12) from the interior area (28). A mechanism urges paper products within the interior area (28) toward the dispensing throat (32) in a dispensing direction (44). Protrusions (50) extend from the portion of the interior surface on the second (20) and third exterior walls (22) into the interior area (28) for contacting the paper products (12) to oppose the mechanism for urging. The protrusions (50) on the second wall are staggered from the protrusions on the third wall (22) in the dispensing direction (44). Additional protrusions may be disposed on the first wall (18), fourth wall (24) and first end wall (40) proximate the dispensing throat (32). A cartridge (262) may be provided for holding and dispensing paper products (12) from the container (10).
Patent CA-2310906-C (CA)
Title: Disposable absorbent article
Inventor: TANJI HIROYUKI
IPC: A61F5/44
Filed: 2000-06-07
Granted: 2004-05-18
Abstract: A disposable absorbent article including a liquid-permeable topsheet 1, which is provided at a desired location of upper and lower surfaces 1a, 1b with a stretchable region 2 adapted to be stretchable up- and downward with respect to the upper and lower surface 1a, 1b, the region 2 being formed by a plurality of pleats 2a.
Patent CA-2320125-C (CA)
Title: Method and device for recording information in units
Inventor: SPRUIT JOHANNES H M
IPC: G11B5/09
Filed: 1999-12-06
Granted: 2009-06-30
Abstract: A method and device for recording information signals on a partly recorded writable record carrier (11), e.g. an optical disc. An information signal represents at least one information unit. The record carrier has a recording track with comprises preformed track position information indicative of locations for recording the information units. From the information signal a modulated signal is generated having successive frames, each frame including a synchronizing signal. The modulated signal is recorded at a one of said locations, while maintaining a fixed relationship between the track position information and the synchronizing signals. In the event that the location is after and adjacent to an already recorded location, the recording is started at a link position (31) before the end of a last frame of the earlier recorded information signal at a predefined distance before a first synchronizing signal (30) of the modulated signal.
Patent CA-2325245-C (CA)
Inventor: THOMAS WILLIAM R
IPC: A01K1/03
Filed: 2000-11-06
Granted: 2008-12-16
Abstract: A housing system for aquatic animals has a shelf-like rack holding tiers o f individual tanks or aquariums (aquaria), each removably suspended from structural members that engage flanges of the tanks. The tanks are tilted inwardly of the rack and have covers with fittings on the higher or outer side, that intercept flow between a supply and a drain to inlet water when the tank is in the rac k and to recycle the water at any tank position that is unoccupied. The inside bottom of each tank is contoured, for example with a longitudinal trough, so sediment collects at a low spot on the lower or inner side, where a drain inlet is placed to provide a drainage outlet that opens at a velocity increasing restriction at which sediment is entrained. The drain has a spring biased valve that opens the drain only when the tank is fully inserted in the rack. Water supply, water drain and air supply conduits are integrated using an extrusion or multiple passage condui t for air supply, water supply and water return at the interception point of the tank water inlet. The housing system is apt for zebrafish for laboratory experimentatio n.
Patent CA-2327694-C (CA)
Title: Method and an apparatus for transfer of pressure and/or tensile load and an elongate chain for use therein
Inventor: SORENSEN JENS JORREN
IPC: F16H19/00
Filed: 1999-03-25
Granted: 2007-06-05
Abstract: For transfer of pressure and/or tensile loads as well as torque load between two objects, an elongate spindle member with high rigidity and stability against pressure and/or tensile loads as well as bending and torsional load is provided by that winding-up of mutually interlocking chain links (1) under axial displacement in a helical winding ( 5) by means of a winding guide means (14) connected with one of the two objects. The turn of the helical winding first provided is connected with a coupling member for connection with the other two objects and each chain link is retained in engagement with neighbouring links in the same turn as well as adjacent chain links in neighbouring turns.
Patent CA-2327697-C (CA)
Title: Epoxidation process using a zeolite catalyst
Inventor: JEWSON JENNIFER D
IPC: B01J29/89
Filed: 1999-04-15
Granted: 2008-07-29
Abstract: The selectivity of an olefin epoxidation catalyzed by a noble metal-modified titanium or vanadium zeolite is greatly enhanced by the addition of a nitrogen compound to the reaction mixture. The epoxidation utilizes hydrogen and oxygen in addition to the olefin.
Patent CA-2329290-C (CA)
Inventor: CABELL DAVID WILLIAM
IPC: D04H1/4266
Filed: 2000-12-20
Granted: 2007-04-10
Abstract: A flexible structure comprises a plurality of starch filaments. The structure comprises at least a first region and a second region, each of the first and second regions having at least one common intensive property selected from the group consisting of density, basis weight, elevation, opacity, crepe frequency, and any combination thereof. The common intensive property of the first region differs in value from the common intensive property of the second region.
Patent CA-2330809-C (CA)
Inventor: COUDRAY GERARD
IPC: B41J11/00
Filed: 2000-03-15
Granted: 2007-08-28
Abstract: The invention concerns a device comprising a belt (10) with one side opposite unsprung support means and extending between an upstream roller (19) and a downstream roller (22) both suspended so that the object (2) can be sandwiched between the unsprung support means and said belt (10) side, the latter being wound around at least two other rollers (18, 20, 21) whereof at least one (18, 21) is unsprung.
Patent CA-2334459-C (CA)
Inventor: SUOLAHTI YRJOE
IPC: B65B61/10
Filed: 2001-02-07
Granted: 2005-05-10
Abstract: The invention relates to a film treatment device (1) in conjunction with a wrapping apparatus and to a wrapping apparatus provided with a film treatment device. The film treatment device comprises a cutting device (2) for the cutting of a plastic film web (F). The cutting device (2) comprises an elongated electric resistor (5) fastened by both ends with fastening elements (3, 4), against which resistor. the film web can be pressed and cut via heating of the electric resistor. The cutting device (2) comprises a supporting element (6) disposed to support the electric resistor laterally substantially over the entire length of the electric resistor between the fastening elements (3, 4).
Patent CA-2334995-C (CA)
Title: Removable case for opening and closing a pressurized can provided with a frangible obturator
Inventor: MARTIN DIDIER
IPC: B65D51/18
Filed: 1998-06-17
Granted: 2005-11-29
Abstract: A method and device for opening a drink can provided with a frangible obturator which can be pushed back inside the can using a tongue that is fixed in a horizontal position in the middle of the lid by means of a rivet on which the tongue can pivot as a lever to produce an opening which is later closed by a movable case that is adapted on the tongue which is pivoted around the river in order to move onto the opening.
Patent CA-2335860-C (CA)
Inventor: FISH WILLIAM G
IPC: A47L9/14
Filed: 1999-06-01
Granted: 2008-05-27
Abstract: L'invention concerne un ensemble de fixation pour sac d'aspirateur utilisé avec des sacs d'aspirateur du type de ceux présentant un bord annulaire sensiblement rigide entourant l'ouverture du sac et avec des aspirateurs du type de ceux ayant une buse d'évacuation (20) de l'air aspiré et un ensemble de fixation (10) du sac d'aspirateur. L'ensemble comprend un élément de fixation (36) présentant une ouverture centrale permettant de recevoir la buse d'évacuation (20) de l'air aspiré. L'ensemble comprend aussi un élément de montage (38) s'accouplant au bord annulaire du sac (24) afin de fixer le sac (24) à l'élément de montage (38) du sac. Cet élément est relié de manière rotative à l'élément de fixation (36) et se déplace entre une position de charge dans laquelle le sac peut être inséré ou retiré de l'élément de montage (38) et une position opérationnelle dans laquelle l'ouverture du sac s'accouple avec la buse d'évacuation (20) de l'air aspiré.
Patent CA-2337914-C (CA)
Title: Interleaver using co-set partitioning
Inventor: LI BIN
IPC: H03M13/00
Filed: 1999-09-29
Granted: 2006-05-23
Abstract: Construction of a Turbo code interleaves for blocks of any size is facilitated by partitioning the block into co-sets of predetermined size, permuting each co-set with an interleaves whose parameters are selected and optimized for the predetermined size, and recombining the elements of the permuted co-sets according to a predetermined order. Partitioning of the block into co-sets is accomplished by choosing a value n for the number of co-sets, and assigning to each co-set those positions of the block having a common value for modulo-n of the block size. The permuted output may be punctured to maintain a desired ratio.
Patent CA-2340720-C (CA)
Inventor: CARPENTER CHARLES
IPC: G01N33/58
Filed: 1999-08-06
Granted: 2011-09-27
Abstract: A self-contained signal generating device and methods for using and making the same are provided. The device and methods may detect the presence of a number of different substances, such as proteins, and utilizes a target material binding dye, which may precipitate a target material as well as stain it, and/or undergo a detectable change, e.g., an absorption or emission frequency shift, on binding of the substance to be detected.
Patent CA-2354933-C (CA)
Title: Manufacturing method of cushion member
Inventor: TANAKA MASASHI
IPC: A47C7/02
Filed: 2001-08-10
Granted: 2007-10-02
Abstract: A manufacturing method of a cushion member which has a two-layer structure constituted by an obverse layer portion and a reverse layer portion and has no dispersion of thickness between the obverse layer portion and the reverse layer portion.  Side cavities, a first cavity and a second cavity are formed in a lower die and side partitions and a front and rear partition are provided therein. A first raw material foams and flows within the first cavity, and a second raw material flows within the first cavity while being limited by a front and rear flow port with respect to a flow amount and a flow direction and covers over the first raw material so as to flow forward in such a manner as to follow the flow of a flow front end portion of the first raw material. Then, an obverse layer portion and a front edge portion made of the first raw material, and a reverse layer portion made of the second raw material are formed in the first cavity.
Patent CA-2358466-C (CA)
Inventor: COOK C EDGAR
IPC: C07J21/00
Filed: 1999-12-03
Granted: 2008-04-15
Abstract: The invention is directed to a novel class of 170-acyl-17.alpha.-propynyl steroids which exhibit potent antiprogestational activity.
Patent CA-2359580-C (CA)
Title: Mobility assisting device
Inventor: HERMAN HARRY JR
IPC: A61H3/00
Filed: 2000-01-24
Granted: 2007-06-26
Abstract: A mobility assisting device (110) which includes a vertical support structure (116) pivotally coupled to a substantially planar base structure (114). The vertical support structure (116) can have an underarm support (134) so that the base (114) remains parallel to the ground as the base (114) moves relati ve to the ground. The underarm support (134) is mounted to the vertical support structure (116) so as to be pivotal relative thereto to avoid the translatio n of pressure points under the patient's arms and rubbing between the upper end of the support (116) and the underarm. The underarm support (134) is angled relative to the plane of the device (110) to increase the comfort of the use r. The base (120) is biased perpendicular to the support structure (116) by a resilient shock dampening pad (130) between the support structure (116) and the base (114). <IMG>
Patent CA-2369504-C (CA)
Title: Pyrazole compositions useful as inhibitors of erk
Inventor: BEMIS GUY
IPC: C07D231/38
Filed: 2001-02-05
Granted: 2009-01-06
Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: (I) where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
Patent CA-2372284-C (CA)
Title: Elastic films including crystalline polymer and crystallizable polymers of propylene
Inventor: DATTA SUDHIN
IPC: C08L23/12
Filed: 2000-05-12
Granted: 2011-07-05
Abstract: Improved thermoplastic polymer elastic film blend compositions including a crystalline isotactic polypropylene component and a crystallizable alpha-olefin and propylene copolymer component, the copolymer having crystallizable alpha-olefin sequences. In a preferred embodiment, improved thermoplastic polymer blends are provided made up of from 0 % to 95 %, preferably 2 % to 40 weight % of the crystalline isotactic polypropylene and from 5 % to 100 %, preferably 60 % to 98 weight % of a crystallizable ethylene and propylene copolymer, wherein the copolymer has isotactically crystallizable propylene sequences and is predominately propylene. The resultant blends manifest unexpected compatibility characteristics, and improved resistance to elastic deformation of the crystalline isotactic polypropylene and from of a crystallizable ethylene and propylene copolymer.
Patent CA-2373802-C (CA)
Inventor: SAVICKI ALAN F SR
IPC: B65D33/24
Filed: 1999-06-10
Granted: 2007-05-01
Abstract: Le réceptacle (100) de cette invention comporte un dispositif de fermeture (121) et une surface de préhension (128). Le dispositif de fermeture comprend des bandes de fixation verrouillables (130, 131) et un élément coulissant (132) disposé coulissant sur les bandes de fixation afin de faciliter leur fermeture et leur ouverture. La surface de préhension (128) facilite l'ouverture et la fermeture du dispositif de fermeture (121) ainsi que le stockage et le retrait des objets se trouvant à l'intérieur du réceptacle (100). La surface de préhension (128) présente une surface supérieure (149) et une surface inférieure (150) et peut avoir différentes configurations. Pour former la surface de préhension (128), on ajoute ou on retire un matériau de la paroi latérale (122), ou on la modifie.
Patent CA-2374528-C (CA)
Title: Code reading apparatus, entertainment system and recording medium
Inventor: TATSUTA SEIJI
IPC: A63F13/213
Filed: 2002-03-05
Granted: 2009-07-21
Abstract: A code reading apparatus main body optically reads a code from a recording medium, recording it as optically readable code, and stores the outcome of the reading operation and the parameters acquired during the reading operation in the data RAM of an application program storing cartridge. When a program processing apparatus reads the outcome of the reading operation as stored in the data RAM, it provides randomness to the outcome of the reading operation according to the parameters stored in the data RAM.
Patent CA-2375984-C (CA)
Inventor: TAKAHIRA RYOICHI
IPC: G11B15/467
Filed: 2000-08-03
Granted: 2006-11-28
Abstract: Input signal converting means (1, 2, 3, 10) converts an input signal into a recording signal through modulation carried out at a timing corresponding to a predetermined number of tracks per one section of a signal. Recording means (7, 8, 10) records the recording signal on a recording tape (.alpha.) by turning a cylinder head (8) at a rotational speed lower than that of the cylinder head (8) corresponding to the modulation timing.
Patent CA-2380712-C (CA)
Inventor: PROSISE ROBERT LAWRENCE
IPC: A61Q1/00
Filed: 2000-08-17
Granted: 2005-04-26
Abstract: L'invention concerne des films discontinus pratiquement uniformes d'un produit de soins de la peau, ayant une taille moyenne de particule, un espacement moyen entre particules et un pouvoir couvrant définis. Les films selon l'invention améliorent l'aspect de la peau en lui fournissant une bonne couverture apparente en maintenant une apparence naturelle. Les films selon l'invention peuvent être produits par tout procédé fournissant la taille de particule, l'espacement entre particules et le pouvoir couvrant définis, notamment par des procédés sérigraphiques et similaires et par des techniques de pulvérisation électrostatiques. On forme les films selon l'invention de préférence par pulvérisation électrostatique de la composition sur la peau.
Patent CA-2381107-C (CA)
Title: Standoff compensation for nuclear measurements
Inventor: MICKAEL MEDHAT W
IPC: G01V5/04
Filed: 2002-04-09
Granted: 2012-08-28
Abstract: A nuclear logging-while-drilling measuring systems, and the correction of the formation property measurements for adverse effects of instrument standoff from the borehole wall, is disclosed. Detector responses for one or more downhole detectors are sampled and recorded over a time segment. The response samples are then sorted by magnitude, and a running integral of the sorted samples as a function of time is performed over the time segment. Linear segments are then fitted to the running integral, wherein each straight line segment is a function of one or more formation properties, and also a function of the standoff distance of the detector from the borehole wall. Segments are then combined to obtain a measure of one or more formation properties of interest such as formation density, where the adverse effects of borehole standoff are minimized. Standoff magnitude is also obtained and can be used to correct other logs, such as a neutron porosity log, for adverse effects of tool standoff and borehole size. No independent caliper of the borehole is required to perform the standoff correction.
Patent CA-2381882-C (CA)
Title: Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases
Inventor: GREEN JEREMY
IPC: C07D405/04
Filed: 2000-08-11
Granted: 2011-01-25
Abstract: The present invention provides compounds of formula (I) where R1 is H, CONH2, T(n)-R, or T(n)-Ar2, n may be zero or one, and G, XYZ, and Q are as described below. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
Patent CA-2386850-C (CA)
Inventor: WIGERINCK PIET TOM BERT PAUL
IPC: A61K31/34
Filed: 2000-10-06
Granted: 2010-03-30
Abstract: The present invention relates to novel bis-tetrahydrofuran benzodioxolyl sulfonamide compounds which are sur-prisingly effective protease inhibitors. The invention also relates to pharmaceutical compositions, methods of inhibiting retrovirus proteases, in particular multidrug resistant retrovirus proteases, methods of treating or combating infection or disease associated with retrovirus infection in a mammal, and methods of inhibiting viral replication.
Patent CA-2387572-C (CA)
Inventor: GRASMANN JOSEF
IPC: G09F9/37
Filed: 2000-10-05
Granted: 2007-08-28
Abstract: The invention relates to a device for representing letters, numbers or symbols, especially for pricing goods. Said device comprises slide elements that are slidable within a base body. The aim of the invention is to provide a device of said kind that is small and handy and that allows the representati on of letters, numbers and symbols without requiring a store of various signs a nd without having to combine the letters, numbers or symbols that are necessary to give the desired representation in a complicated, jigsaw puzzle-like manner. To this end, the slide elements (3) are retained in the opening (2) by means of a sliding seat or a loose fit.
Patent CA-2387600-C (CA)
Inventor: VON DAEHNE WELF
IPC: C07J13/00
Filed: 2000-10-12
Granted: 2007-08-21
Abstract: Novel 17,20-dihydrofusidic acid deriva-tives (Ia) are used in pharmaceutical compositions for the treatment of infections, in particular in topical composi-tions for the treatment of skin or eye infections.
Patent CA-2387868-C (CA)
Inventor: LOVELACE JOHN H II
IPC: B61L3/12
Filed: 2000-10-25
Granted: 2010-08-31
Abstract: A method and apparatus for determining whether a vehicle is configured with the correct versions of software that controls the various operational systems aboard the vehicle. The version numbers for software on board the vehicle are periodically determined by an on-board monitoring system. This information is later transmitted to a remote site, where the actual software version numbers are compared to the correct software versions. If there is a mismatch, personnel at the remote site are alerted to resolve the mismatch.
Patent CA-2389628-C (CA)
Title: Bone implant
Inventor: LOWEL MATTHIAS
IPC: A61B17/88
Filed: 2000-10-30
Granted: 2007-03-13
Abstract: The inventive bone implant for replacing defective joint sockets comprises a base body (10) consisting of preserved natural spongiosa with an approximately hemispherical cavity (12).