baber/WOPTO huggingface dataset:
Patent RU-2708026-C2 (RU)
Title: Modified sulphamidase and method for production thereof
Inventor: BERGKHARD Sharlotta
IPC: C07K14/435
Filed: 2015-04-01
Granted: 2019-12-03
Abstract: FIELD: biotechnology. 
     SUBSTANCE: group of inventions relates to biotechnology. Modified sulfamidase comprises a polypeptide consisting of the amino acid sequence given in SEQ ID NO 1, or a polypeptide having at least 95 % sequence identity with the amino acid sequence given in SEQ ID NO 1. Disclosed sulphamidase essentially does not include epitopes recognized by glycan-recognizing receptors, wherein said epitopes are absent on at least four of five N-glycosylation sites: N in position 21 (N(21)), N in position 122 (N(122)), N in position 131 (N(131)), N in position 244 (N(244)) and N in position 393 (N(393)) of SEQ ID NO 1. Composition of sulphamidase for treating a mammal suffering from lysosomal accumulation disease includes said sulfamidase. Said sulfamidase has a C ratioα-formylglycine (FGly) to serine (Ser) on an active site is greater than 1. Method of producing modified sulphamidase involves steps of subjecting glycosylated sulphamidase to reaction with a periodate of an alkali metal and reacting with an alkali metal borohydride for a period of time of not more than 2 h to modify glycation groups of sulphamidase and reduced activity of sulphamidase towards receptors recognizing glycans, preserving its catalytic activity. Method of treating a mammal suffering lysosomal accumulation disease, such as IIIA (MPS IIIA), involves administering to a mammal a therapeutically effective amount of modified sulphonidase selected from said modified sulphonidase and said sulphonidase composition. 
     EFFECT: group of inventions provides penetration of said sulphamidase through a blood-brain barrier of a mammal and to exhibit catalytic activity in its brain. 
     31 cl, 18 dwg, 6 tbl, 11 ex
Patent RU-2678025-C2 (RU)
Title: Оснастка для формирования профилированной ферменной конструкции из композиционного волокнистого материала
Inventor: Andryushkin Aleksandr Yurevich
IPC: B29C43/00
Filed: 2017-02-15
Granted: 2019-01-22
Abstract: Изобретение относится к области изготовления профилированных ферменных конструкций из композиционного волокнистого материала и может быть использовано в авиационной и космической технике. Оснастка для формования профилированной ферменной конструкции из композиционного волокнистого материала содержит основание, на верхней поверхности которого выполнена формующая канавка, а снизу выполнены точечные опоры. При этом непрерывный маршрут формующей канавки представляет собой вложенные друг в друга два или более витка. В местах усиления профилированной ферменной конструкции витки соприкасаются друг с другом. На верхней поверхности основания установлена крышка с формующей поверхностью, закрывающей формующую канавку. Формующая поверхность крышки и формующая канавка основания образуют формующий канал для укладки композиционного волокнистого материала. Формующий канал имеет одинаковую по периметру толщину δ стенки. Изобретение обеспечивает создание оснастки для формования профилированной ферменной конструкции из композиционного волокнистого материала с геометрическими формами высокой точности. 8 ил.
Patent RU-2719446-C2 (RU)
Inventor: KICZUN MICHAEL
IPC: A61P31/04
Filed: 2015-11-02
Granted: 2020-04-17
Abstract: FIELD: pharmaceuticals. 
     SUBSTANCE: invention relates to specific compounds specified in claim 1, as well as to a compound having general formula given below, where R 4  is selected from hydrogen, halogen and C 1 -C 6  alkyl; and Y is a group having formula given below, where L is absent, each R 313  is independently selected from H, halogen and C 1 -C 6  alkyl and R" is selected from H and C 1 -C 6  alkyl or its pharmaceutically acceptable salts. Declared compounds inhibit tryptophan-2,3-dioxygenase (TDO) or indolamine-2,3-dioxygenase (IDO). Invention also relates to pharmaceutical compositions based on said compounds.    . 
     EFFECT: disclosed is a pharmaceutical compound. 
     6 cl, 2 dwg, 3 tbl, 2 ex
Patent RU-2677128-C2 (RU)
Title: Способ производства ультрафильтрационного биотворога
Inventor: TIMKIN VIKTOR ANDREEVICH
IPC: A23C19/076
Filed: 2017-05-31
Granted: 2019-01-15
Abstract: Изобретение относится к пищевой промышленности, в частности к молочной. Способ предусматривает микрофильтрацию обезжиренного молока с использованием керамических мембран с диаметром пор 0.8 мкм при температуре 30±5°С и давлении 0,3 МПа. При микрофильтрации входящий поток разделяют на две фракции: пермеат и концентрат. В пермеат вносят закваску, сгусток перемешивают, нагревают до температуры 45°С и подают на ультрафильтрационную установку с использованием керамических мембран с диаметром пор 0,01 мкм при температуре 53±2°С и давлении 0,5 МПа. Процесс концентрирования ведут до достижения содержания сухих веществ 20%. Полученный в процессе разделения концентрат представляет собой раствор сливочной структуры с содержанием сухих растворенных веществ около 20%. Пермеат представляет собой прозрачный раствор со слабым по окраске желто-зеленым цветом. Концентрат охлаждают до температуры 8±2°С, фасуют, упаковывают и маркируют. Изобретение позволяет максимально сохранить в продукте сывороточные белки и увеличить срок его хранения. 2 табл., 1 пр.
Patent RU-2706331-C2 (RU)
Title: 2-oxo-3,4-dihydroquinoline compounds as plant growth regulators
Inventor: LASHIYA Matilda Deniz
IPC: C07D401/04
Filed: 2016-02-05
Granted: 2019-11-18
Abstract: FIELD: chemistry. 
     SUBSTANCE: invention relates to novel sulphonamide derivatives of formula (I),  
     
       
     
     where R1 is selected from a group consisting of C 1 -C 6 alkyl, C 1 -C 6 halogenalkyl, C 3 -C 6 alkenyl and C 3 -C 5 cyclopropyl-C 1 -C 6 -alkyl; R2 is selected from a group consisting of hydrogen and C 1 -C 4 alkyl; R3 is selected from a group consisting of hydrogen, halogen and C 1 -C 4 alkyl; R7 and R8 are independently selected from a group consisting of hydrogen, halogen, cyano, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, C 1 -C 4 halogenalkyl, C 1 -C 4 haloalkoxy and C 3 -C 4 cycloalkyl; R4 and R5 are independently selected from a group consisting of hydrogen, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl and C 3 -C 4 cycloalkyl; or R4 and R5 can form together with atom or atoms, to which they are directly connected, C 3 -C 4 cycloalkyl or C 4 heterocyclyl; R6 is hydrogen; L is selected from group consisting of link, linear -C 1 -C 4 -alkyl chain, linear -C 2 -C 4 -alkenyl chain and linear -C 2 -C 4 -alkynyl chain; A is hydrogen, C 1 -C 7 alkyl, C 3 -C 5 cycloalkyl, 3–10-member heterocyclyl or aryl, each of which is optionally substituted with one to three Ry, and where heterocyclyl moieties contain from one to four heteroatoms selected from nitrogen, oxygen and sulfur; Ry independently of each other is selected from a group consisting of halogen, cyano, nitro, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 halogenalkyl, C 1 -C 4 haloalkyloxy, C 1 -C 4 haloalkylsulfanyl and C 3 -C 4 cycloalkyl; where A is not butyl, if either R4 or R5 is methyl; and where R1 is not methyl, if each of R2, R3, R4, R5, R6, R7 and R8 is hydrogen. 
     EFFECT: compounds of the invention are used to improve plant endurance with respect to stress caused by abiotic factors. 
     9 cl, 5 tbl, 6 ex
Patent RU-2690922-C2 (RU)
Title: Многоступенчатая дистилляционная установка и способ ее эксплуатации
Inventor: LEHMANN MARKUS
IPC: B01D1/00
Filed: 2016-02-10
Granted: 2019-06-06
Abstract: Изобретение относится к дистилляционным установкам, служащим для подготовки воды или для отделения спирта от других жидкостей и применяющимся во многих других установках, способам осуществления дистилляции, а также к системам управления. Изобретение касается многоступенчатой дистилляционной установки со ступенями Si, где i=l,…n, причем в рабочем режиме каждая ступень Si работает в области более высокого давления и температуры (Pi, Ti), чем следующая за ней ступень Si+1, причем каждая ступень Si содержит испаритель Ei и конденсатор Ci, причем каждый испаритель Ei и каждый конденсатор Ci содержат прочную на сжатие емкость с пространством над жидкостью, причем пространство над жидкостью каждого испарителя Ei соединено по давлению с пространством над жидкостью конденсатора Ci той же ступени Si через паропроводную трубу большого поперечного сечения. Каждый выпуск каждого испарителя Ei соединен с распыляющим впуском следующего испарителя Ei+1, и выпуск последнего испарителя En соединен с распыляющим впуском первого испарителя El соответствующим жидкостным трубопроводом с объединением в испарительный контур, а каждый выпуск каждого конденсатора Ci соединен с распыляющим впуском предшествующего конденсатора Ci-1, и выпуск первого конденсатора CI соединен с распыляющим впуском последнего конденсатора Cn жидкостным трубопроводом с объединением в конденсационный контур. Согласно изобретению по меньшей мере один паропровод первым концом соединен с одним из жидкостных трубопроводов между конденсаторами Ci+1 и Ci или с жидкостным трубопроводом между испарителями En и E1, а вторым концом соединен с пространством над жидкостью, которое в рабочем режиме имеет более высокое давление P, чем давление Pi в пространстве над жидкостью конденсатора Ci, соответственно, чем давление P1 в пространстве над жидкостью испарителя E1. Технический результат – усовершенствование, приводящее к снижению расхода электроэнергии, создание системы управления для эксплуатации установки. 3 н. и 17 з.п. ф-лы, 3 ил.
Patent RU-2714625-C2 (RU)
Title: Endodontic device and method of facilitating training dentists of given endodontic technique (embodiments)
Inventor: PIRA FRANCHESKO
IPC: A61C1/00
Filed: 2016-04-26
Granted: 2020-02-18
Abstract: FIELD: medicine. 
     SUBSTANCE: group of inventions relates to an orthodontic device and methods of facilitating training dentists given technique of endodontic treatment. Device comprises a dental drill tip (2) configured to attach to it endodontic instrument (4) for insertion into a tooth root canal, measuring unit (9) for measuring a specific parameter characterizing the position of endodontic instrument (4) in the root canal and computation-display unit (5) for displaying a graph reflecting a gradual change of said specific parameter measured by measuring unit (9) in endodontic treatment using endodontic instrument (4). Method according to the present invention comprises the following steps: displaying a graph using computation-indicator unit (5) reflecting a gradual change of a certain parameter measured in treating a root canal performed by a dentist, wherein said parameter characterizes position of endodontic instrument in root canal, and use of reference graph reflecting features of specified endodontic technique, with possibility of comparing said graph reflecting gradual change of measured parameter with said reference plot. 
     EFFECT: inventions, by providing assistance in training dental professionals, improve efficiency of endodontic treatment. 
     20 cl, 9 dwg
Patent RU-2761433-C2 (RU)
Title: System for controlling integrated functions of vehicle interface, method for controlling system for controlling integrated functions of vehicle interface and vehicle containing system for controlling integrated functions of vehicle interface
Inventor: ZADEMACH MARTIN
IPC: B60R16/02
Filed: 2018-02-22
Granted: 2021-12-08
Abstract: FIELD: vehicle control. 
     SUBSTANCE: invention relates to a system for controlling integrated functions of a vehicle interface and a method for controlling the system for controlling integrated functions of the vehicle interface. The system for controlling integrated functions of the vehicle interface includes an indication device having an indication surface, a storage device for storing elements of a list having the beginning and the end of the list, an input element for selecting the list element by a user, and a control device that is connected to the indication device and the input element and that is made with the possibility of controlling the reproducing indication on the indication surface. The indication surface is made with the possibility of being activated by the control device in such a way that at least part of list elements is indicated on the indication surface in the form of an endlessly scrolling list, selected list elements are changed using passing the list caused by involvement of the input element in the direction of passing the list, when reaching the beginning of the list or the end of the list, passing the list in the previous direction of passing the list is stopped, the resumption of stopped passing the list is unlocked by means of direct passage from the end of the list to the beginning of the list or by means of direct passage from the beginning of the list to the end of the list, only when the set time range expires, which begins, when the involvement of the input element is interrupted. The control system is made in such a way that, when reaching, immediately before reaching and/or immediately after reaching the beginning of the list or the end of the list, an optical, acoustic and/or haptic signal is generated. 
     EFFECT: increase in ease of controlling integrated functions of the vehicle is achieved. 
     15 cl, 7 dwg
Patent RU-2728723-C2 (RU)
Title: Slide actuating the surgical stapling device with a drive stroke with a minimum distance from the distal staple
Inventor: SHEJB CHARLZ DZH
IPC: A61B17/072
Filed: 2016-10-07
Granted: 2020-07-30
Abstract: FIELD: medical equipment.SUBSTANCE: invention relates to a surgical instrument. Surgical instrument for treating a patient's tissue comprises a barrel assembly, an end effector and a staple cassette. End effector extends from the shaft assembly along the central line of the branch. End effector comprises a first branch and a second branch. First jaw has a stop configured to form staples pressed to the anvil. First and second jaws are configured to switch between open configuration and closed configuration. Staple cartridge is placed inside the second branch. Staple cartridge comprises a platform, a first end extractor assembly and a wedge-like slide. Platform faces the limit stop. Platform forms holes for staples. Brackets are located inside staple holes. First unit of the end extractor is located adjacent to the distal end of the staple cartridge. First unit of the end pusher is configured to receive the first end portion of the staples. First unit of the end extractor at least partially forms under itself space for storage inside the second branch. Wedge slides are made with possibility to slide near platform from proximal position of slides in distal position of slides and engagement of first unit of end extractor, and forced movement of end part of staples to support for formation in fabric. At least a greater part of the length of the wedge-like slides is configured to be placed in the storage space, without sliding in the distal direction beyond the first unit of the end extractor, when wedge-like slides are in distal position of slide. Wedge-like slides comprise the first cam inclined surface made with possibility of engagement with the first unit of end extractor. First cam inclined surface comprises front cam surface and intermediate cam surface. Front cam surface forms the first inclination angle between the lower surface and the front cam surface. Intermediate cam surface forms second inclination angle between lower surface and intermediate cam surface. First angle of inclination of the front cam surface is more, than the second angle of inclination of the intermediate cam surface. Extractor assembly is configured to engage with the front cam surface to lift the ejection assembly upward at a first upper distance to the first branch at a first distal distance. Ejector assembly is made with possibility of engagement by intermediate cam surface for additional lifting of ejector assembly upwards to second upper distance to first branch to a second distal distance to provide sufficient force for pressing end part of staples to a stop for use in tissue. First upper distance is greater than second upper distance.EFFECT: using the invention enables tissue cross-linking and dissection in the patient's body.14 cl, 16 dwg
Patent RU-2732878-C2 (RU)
Title: Multiband communication
Inventor: FERRER FLORIT ALBERT
IPC: H04L45/28
Filed: 2017-01-27
Granted: 2020-09-25
Abstract: FIELD: communication equipment. 
     SUBSTANCE: invention relates to a multi-band communication interface in a SpaceFibre line used onboard a spacecraft. For this purpose, there is a logic unit, during operation at near end together with interface of multi-band communication of far end to establish symbol synchronization with far end along one or several bands; send data words to far end and receive them from it, while preserving symbol synchronization (A); detecting strip state change (610); and after detecting change in band state (610) and stopping sending (B) data words when symbol synchronization is maintained; send (B) near-end band status control words to far end instead of data words, until (604) it is determined that the near end is ready to send data words, then resume sending (C) data words; and send (C) near end band alignment signals to far end unless (608) data word is received from far end. 
     EFFECT: technical result is possibility of both ends of communication line to resume operation, even if on one or more bands there are random errors leading to loss of transmitted information. 
     18 cl, 7 dwg
Patent RU-2724413-C2 (RU)
Title: Разделительное устройство для змеевиковых теплообменников для отделения газовой фазы от жидкой фазы двухфазной среды, подаваемой со стороны обшивки
Inventor: STEINBAUER MANFRED
IPC: F28D7/02
Filed: 2017-03-15
Granted: 2020-06-23
Abstract: Предложен змеевиковый теплообменник (1) для косвенного теплообмена между двухфазной первой средой (М) и второй средой (М'), имеющий корпус (5), который окружает пространство (6) корпуса и проходит вдоль продольной оси (z), впуск (7) для подачи двухфазной первой среды (М) в пространство (6) корпуса, пучок (3) труб, который расположен в пространстве (6) корпуса и имеет множество труб (30) для прохождения второй среды (М'), которые спирально навиты вокруг продольной оси (z), и разделяющее устройство (2) для отделения газовой фазы (G) от жидкой фазы (F) двухфазной первой среды (М). Согласно изобретению разделительное устройство (2) имеет поддон (4), который расположен выше пучка (3) труб и служит для сбора жидкой фазы (F), причем поддон (4) имеет множество патрубков (50, 70), предназначенных для разделения двух фаз (F, G), причем соответствующий патрубок (50, 70) выступает из поддона со стороны поддона (4), обращенной в сторону от пучка (3) труб, закрыт крышкой (52, 72) и открывается в проходное отверстие (40) в поддоне (4), и при этом между соответствующей крышкой (52, 72) и верхним концом соответствующего патрубка (50, 70) выполнено впускное отверстие (51, 71), через которое газовая фаза (G) может протекать в соответствующий патрубок (50, 70). Изобретение также относится к соответствующему способу работы теплообменника. 2 н. и 13 з.п. ф-лы, 5 ил.
Patent RU-2720955-C2 (RU)
Inventor: SPENCER ALFRED VINCENT
IPC: A24F40/20
Filed: 2017-04-28
Granted: 2020-05-15
Abstract: FIELD: smoking accessories. 
     SUBSTANCE: article (110) for generation of inhaled medium by means of radiation source (122) contains smoking material (112), including at least two regions of different composition. 
     EFFECT: article (110) is designed so that at least two areas of smoking material (112) can be heated by radiation generated by light source (122) of device (120) with which said article (110) is connected during use. 
     32 cl, 11 dwg
Patent RU-2737202-C2 (RU)
Title: System information on request for wireless communication
Inventor: ISHII ATSUSHI
IPC: H04W48/10
Filed: 2017-07-25
Granted: 2020-11-25
Abstract: FIELD: wireless communication systems. 
     SUBSTANCE: technical result is achieved by transmitting a first type system information unit to the user equipment from the base station, wherein first type system information unit is used for minimum system information containing a plurality of instructions, each of the indications indicates whether delivery of the second type information system information block, upon request, and receiving a request for transmitting a corresponding second type information system unit in case, when one of plurality of instructions indicates that delivery of the corresponding system information unit of the second type is provided upon request. 
     EFFECT: technical result is higher efficiency of transmitting system information blocks (SIB), by providing differentiated delivery of second type system information by broadcasting second type system information, carried out separately from broadcasting of system information of the first type. 
     16 cl, 17 dwg
Patent RU-2766529-C2 (RU)
Title: Magnetic sensor of displacements frequency
Inventor: Kotenkov YUrij Alekseevich
IPC: G01P3/42
Filed: 2019-07-08
Granted: 2022-03-15
Abstract: FIELD: measuring equipment. 
     SUBSTANCE: magnetic sensor of displacements frequency comprises a magnetic field source based on a permanent magnet fixed on the movable controlled object and a magnetic field converter installed in the housing, the sensitivity axis of which is parallel to the longitudinal axis of the sensor, wherein magnetic field converter is made in form of working throttle with core of rod type, installed in tip of housing on electronic printed circuit board located along longitudinal axis of housing, at some distance from working throttle and perpendicular to it on electronic printed-circuit board there fixed is a choke for comparison of inductances. Results of comparison of the measured values are used to determine the presence or absence of a permanent magnet in the tip of housing sensitivity zone. 
     EFFECT: broader functional capabilities of the sensor. 
     5 cl, 2 dwg
Patent RU-2769680-C2 (RU)
Inventor: Nenashev Sergej Aleksandrovich
IPC: C23C2/04
Filed: 2019-06-13
Granted: 2022-04-05
Abstract: FIELD: metallurgy. 
     SUBSTANCE: invention relates to devices for manufacturing a steel tape. The device contains a continuous flow heating furnace, a sock connected to the continuous flow heating furnace, a hot melt bath, a roller made with the possibility of changing the direction of the trajectory of the steel tape after it passes through the sock, wherein this roller is a submersible roller in the manufacture of the steel tape by immersing it in the hot melt bath, and a deflecting roller in the manufacture of an annealed steel tape. In addition, the device is made with the possibility of selecting a submersible roller or a deflecting roller, depending on the type of a steel tape being manufactured and installing the selected roller in a given position. An additional deflecting roller is installed in the device, made with the possibility of changing the trajectory of the steel tape in front of the heating furnace, wherein this roller allows one to set the steel tape into the continuous heating furnace or bypassing the continuous heating furnace, depending on the type of a steel tape being manufactured, and installing the roller in a given position. In addition, the bath is made with the possibility of filling it with a quenching medium as a hot melt.  
     EFFECT: compact design of the device and possibility of implementing various heat processing modes, including tempering, recrystallization annealing or hardening of the tape in one installation. 
     1 cl, 3 dwg