baber/WOPTO huggingface dataset:
Patent CA-2430409-A1 (CA)
Title: Bisubstituted carbocyclic cyclophilin binding compounds and their use
Inventor: STEINER JOSEPH P
IPC: A61P31/18
Filed: 2001-11-28
Abstract: The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins. In the compounds of this invention, at least two carbo-or heterocyclic groups are attached to a central saturated, partially saturated, or aromatic 5-6 membered carbocyclic ring by a combination of straight or branched linker chains. The invention further relates to pharmaceutical compositions comprising one or more of the said compounds, and to the uses of these compounds and compositions for binding CyP-type proteins, inhibiting their peptidyl-prolyl isomerase activity, and for research, development, and therapeutic applications in a variety of medical disorders, such as neurological disorders, hair loss disorders, ischemic disorders, and disorders caused by viral or protozoan infection.
Patent CA-2430953-A1 (CA)
Title: Combinatorial libraries of proteins having the scaffold structure of c-type lectin-like domains
Inventor: HOLTET THOR LAS
IPC: C12N15/12
Filed: 2001-12-13
Abstract: A novel family of protein libraries comprising CTLDS (C-type Lectin-Like Domains) in which internal polypeptide loop-regions lining the ligand binding sites in CTLDs have been replaced with ensembles of completely or partially randomised polypeptide segments. Tetranectin CTLDs were chosen as framework for the preferred embodiment of the invention; and versatile phagemid vectors useful in the generation and manipulation of human and murine tetranectin CTLD  libraries are disclosed as part of this invention. Tetranectin CTLDs in monomeric as well as in trimeric form are efficiently displayed as gene III  fusions in fully functional form by the recombinant fd phage display vector.  CTLD derivatives with affinity for new ligands may readily be isolated from libraries of vectors displaying CTLDs, in which loop-regions have been randomised, using one or more rounds of enrichment by screening or selection followed by amplification of the enriched subpopulation in each round. The efficiency with which protein products containing CTLDs with new binding properties can be produced, e.g. by bacterial expression in in vitro refolding, in mono-, tri-, or multimeric formats provides important advantages in terms of simplicity, cost and efficiency of generation, production and diagnostic or therapeutic applications in comparison to recombinant antibody derivatives.
Patent CA-2431298-A1 (CA)
Title: Method of draining and recharging hermetic compressor oil
Inventor: RUTZ JAMES D
IPC: F25B45/00
Filed: 2003-06-05
Abstract: A method of draining and recharging a hermetic compressor with oil using a drainage assembly mounted in the compressor housing. The assembly includes a tube having a valve mounted at one end thereof with the second end of the tube located in the oil sump of the housing. To drain the compressor oil, refrigerant flowing through the discharge and suction lines is shut off. Refrigerant is purged from the housing to create a vacuum therein and the housing is charged with a gas such as dry air or nitrogen. As the compressor housing is charged with gas, the pressure inside the housing increases, forcing the oil through the drainage assembly and out of the compressor. To recharge the compressor with oil, the gases are purged creating a vacuum in the housing. A predetermined amount of oil is drawn into the housing through a service hose. The compressor is purged and recharged with refrigerant.
Patent CA-2438677-A1 (CA)
Title: Appareil de cuisson a gaz
Inventor: BROWN SIMON
IPC: F24C3/02
Filed: 2002-02-08
Abstract: La présente invention concerne un appareil comportant une grille pour le support de récipients de cuisson présentant un fond plat ou bombé. Les différentes variantes comportent une grille réversible qui d'un côté sert de support à des récipients à fond plat et de l'autre des récipients à fond bombé. Le récipient à fond plat peut être maintenu soit par des pattes verticales, un anneau vertical, une ouverture dans la grille, ou un anneau dans la grille.
Patent CA-2439875-A1 (CA)
Title: Ameliorations apportees a des selles de cheval
Inventor: WALKER DANIEL ALEXANDER LLOYD
IPC: B68C1/04
Filed: 2002-03-01
Abstract: L'invention concerne une selle de cheval modulaire qui comprend un arçon (2) pourvu de deux matelassures latérales (8) reliées par un pont (12) articulé de façon à permettre le réglage de l'angle des matelassures latérales (8) et d'une plaque de siège (50) fixée aux matelassures latérales (8).
Patent CA-2441329-A1 (CA)
Title: Screw element for same-sense rotating multi-screw extruders
Inventor: NOLTING MATTHIAS
IPC: B29C48/595
Filed: 2002-03-08
Abstract: The invention relates to a screw element with an outer radius R a and a core radius R i for multiscrew extruders with co-rotating and intermeshing screw shafts, in particular for twin-screw extruders, which has in axial cross section through its longitudinal axis (10) a profile which has at each of the two axial end faces (font end face 8, rear end face 8') only a screw flight (1, 1') corresponding to a conventional single-start screw element for intermeshing screw shafts. In this case, the width (flight land angle ~) of the screw flight (1) and conversely, in a corresponding way, the width (flight land angle ~) of the screw flight (1') are formed in a special way and a shearing flight (7) with a constant shearing flight radius R s, which is greater than Ri and less than R a, is provided.
Patent CA-2443003-A1 (CA)
Title: Fabric care compositions
Inventor: BARBUZZI ELENA
IPC: C11D3/37
Filed: 2002-04-08
Abstract: A method of treating fabric comprising the step of applying to the fabric a fabric treatment composition comprising a coated particles comprising:a solid core having a D3,2 average particle size in the range from 10 to 700 nm, and a coating of silicone polymer covalently bonded to the solid core.
Patent CA-2447609-A1 (CA)
Title: Method and device for producing parts having a sealing layer on the surface, and corresponding parts
Inventor: BECKER-WEIMANN KLAUS
IPC: B05D7/08
Filed: 2002-05-16
Abstract: The invention relates to a method and a device for producing parts (1) having a sealing layer (2) on the surface, and corresponding parts. Said method and device are improved in that the sealing layer (2) is applied to the surface in the form of a water-free and solvent-free reactive hot melt layer based on polyurethane and hardened by atmospheric humidity, and the inventive device comprises an application station (6), a transport device (5) and a smoothing station (8).
Patent CA-2448576-A1 (CA)
Title: Topical composition comprising an aldehyde or ketone-based cosmetic bonding agent
Inventor: BEKELE HAIMANOT
IPC: A61K8/893
Filed: 2002-03-05
Abstract: The present invention relates to cosmetic compositions that comprise; a) a safe and effective amount of a bonding agent selected from the group consisting of aldehydes and ketones having the structure (I) wherein X  represents a cosmetic benefit agent that may or may not be attached via a chemical linker and R represents hydrogen, straight or branched alkyls, substituted or unsubstituted aryls, and combinations thereof; and b) a cosmetically acceptable carrier for the bonding agent wherein the composition is administered topically to mammalian proteinaceous substrates and wherein the bonding agent reacts with a protein contained in the substrate such that the bonding agent, and thus the cosmetic benefit agent, is covalently attached to the substrate. The invention further relates to methods of using the compositions described above as well as various products that include the claimed compositions.
Patent CA-2449775-A1 (CA)
Title: Collapsible scaffolding tower
Inventor: WESTON JAMES THOMAS
IPC: E04G1/34
Filed: 2002-05-30
Abstract: A collapsible scaffolding tower having four uprights arranged in two pairs, wherein each of the uprights is formed of three or more telescopically collapsible sections and rigid horizontal bars extend between the sections of the uprights in each pair to form two telescopically collapsible ladder structures, which rest directly on the ground when the tower is in use.
Patent CA-2452026-A1 (CA)
Inventor: WAYWOOD WILLIAM JOHN
IPC: B32B27/32
Filed: 2002-04-23
Abstract: A biaxially oriented multilayer film usable to form adhesive labels to be attached to containers, such as bottles and cans. The film includes a core layer comprising polypropylene and a migratory slip agent and an outer slip layer on one side of the core layer. The slip layer includes primarily polypropylene, by weight, and a minor percent, by weight, of an additive, with the additive and the migratory slip agent being present in amounts to provide a COF on the surface of the slip layer of no greater than 0.45 and to provide an adhesion of the adhesive employed on the formed label for the slip layer of at least 50%.
Patent CA-2453332-A1 (CA)
Inventor: SHIMEI THOMAS M
IPC: B01L3/14
Filed: 2002-08-09
Abstract: L'invention concerne un connecteur (10) assurant la combinaison de contenu entre une paire de contenants, qui comprend un corps creux (11) pour la circulation de fluides entre les contenants. Le corps (11) comporte des extrémités supérieures (12) et inférieures (13) configurées pour recevoir des contenants ouverts en ajustement serré. L'extrémité supérieure (12) comprend une ou plusieurs cavités (27) dimensionnées et disposées pour faciliter l'écoulement d'un fluide depuis le premier contenant vers le second contenant lorsque le premier contenant est placé au-dessus du premier contenant. Une partie médiane (14) se trouve entre les extrémités du corps, attenante à ces parties du corps (11). Un système de combinaison de contenu d'une paire de contenants est constitué lorsque les contenants qui contiennent des substances à combiner sont fixés aux extrémités (12, 13) du connecteur (10).
Patent CA-2454059-A1 (CA)
Inventor: ZABLOCKI JEFF
IPC: C07D413/12
Filed: 2002-07-18
Abstract: Disclosed are novel heterocyclic derivatives of the formula (I), wherein amongst others R1, R2, R3, R4, R5, R6, R7, and R8 are hydrogen; T is oxygen, sulfur, or NR11, in which R11 is hydrogen or lower alkyl; V is N<, -CH<, or N-CH<; X1 is hydrogen, optionally substituted lower alkyl, optionally substituted cycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; X2 is optionally substituted aryl or optionally substituted heteroaryl; Y is optionally substituted monocyclic heteroarylenyl; and Z1 and Z2 are independently optionally substituted alkylene or 1-4 carbon atoms. The compounds are useful for the treatment of various disease states, in particular cardiovascular diseases such as atrial and ventricular arrhythmias, intermittent claudication, Prinzmetal's (variant) angina, stable and unstable angina, exercise induced angina, congestive heart disease, and myocardial infarction. The compounds are also useful in the treatment of diabetes, and for increasing HDL plasma levels in mammals.
Patent CA-2457888-A1 (CA)
Inventor: LI WEILI
IPC: C12Q1/70
Filed: 2002-08-19
Abstract: L'invention concerne un dosage PCR multiplex fluorescent permettant de détecter la présence d'un sous-type de virus du papillome humain (HPV) dans un échantillon à l'aide de multiples fluorophores, afin de détecter simultanément une pluralité de gènes de HPV du même sous-type de HPV. Cette invention concerne également des paires d'amorces et des sondes spécifiques de sous-types de HPV destinées à être mises en oeuvre dans les procédés de cette invention.
Patent CA-2463125-A1 (CA)
Inventor: TORNBERG CLAES
IPC: B22F9/08
Filed: 2002-09-30
Abstract: L'invention concerne la production d'une poudre métallique formée de particules fissurées superficiellement, dites irrégulières, à savoir, d'une poudre métallique obtenue par atomisation aqueuse. L'invention a pour but d'obtenir une forme superficielle, dite irrégulière, des grains de poudre (23) dans une classe pondérale étroite et conférant, par ailleurs, aux corps frittés, une porosité élevée avec une répartition homogène. A cet effet, l'invention est caractérisée en ce que, dans une première étape, le jet de coulée (2) est dévié dans sa direction d'écoulement et grossi superficiellement et en ce que, dans une deuxième étape, on provoque une nouvelle déviation du jet grossi superficiellement (21), avec division de celui-ci et accélération des particules métalliques liquides formées (22), et en ce que, dans une troisième étape, lesdites particules métalliques (22) sont appliquées et divisées, sous un angle .gamma. de 10 à 90· par rapport à la direction de déplacement de celles-ci, avec un courant à vitesse élevée formé au moins partiellement d'un milieu liquide (51), après quoi les particules (23) sont solidifiées. En vue de réduire la surchauffe du bain fondu métallique et/ou d'améliorer la qualité de la poudre métallique produite, une variante d'exécution de l'invention est caractérisée en ce qu'on provoque une déviation du jet de coulée (2) dans sa direction d'écoulement et un grossissement superficiel de celui-ci (21), dans une première étape du procédé, et/ou une déviation du jet de coulée grossi superficiellement (21) et sa fragmentation, ainsi qu'une accélération des particules métalliques liquides formées (22), dans une deuxième étape du procédé, avec un ou plusieurs courants (6, 31, 41) formés d'un ou de plusieurs gaz chauds ou de mélanges de gaz chauds.
Patent CA-2463902-A1 (CA)
Inventor: PINNEY KEVIN G
IPC: C07F9/12
Filed: 2002-10-28
Abstract: Novel stilbenoid compounds and their prodrug forms are disclosed, which serve as potent vascular targeting agents useful for the treatment of solid tumor cancers and other diseases associated with unwanted neovascularization. The novel stilbenoid compounds are tubulin-binding stilbenoid analogs structurally related to combretastatin A-1 and combretastatin A-4. The prodrug forms serve as potent vascular targeting agents (VTAs) useful for the treatment of solid tumor cancers and diseases associated with retinal neovascularization.
Patent CA-2464341-A1 (CA)
Title: Transport de proteines mal pliees par la voie secretoire et methodes de traitement de maladies associees
Inventor: EGAN MARIE E
IPC: A61K31/365
Filed: 2002-10-15
Abstract: L'invention concerne une méthode et des agents de traitement d'un quelconque état pathologique ou clinique généré au moins en partie par une rétention associée au réticulum endoplasmique des protéines. Les méthodes et les agents de la présente invention permettent ainsi de libérer les protéines normalement retenues par le réticulum endoplasmique. La présente invention est particulièrement utile dans le traitement d'un quelconque état pathologique ou clinique généré au moins en partie par une rétention ou une dégradation associées au réticulum endoplasmique de protéines mal assemblées ou mal pliées.
Patent CA-2464743-A1 (CA)
Title: Cabinet spout assembly
Inventor: PIATT JAMES M
IPC: A47B46/00
Filed: 2002-10-24
Abstract: A medicine cabinet (30) for mounting on a wall above a sink includes a cabin et frame (32) and a door (36) pivotally attached to the front of the cabinet frame (32). A mirror (20) is attached to the exterior surface of the door (3 6) and has an aperture (at 18) there through. A shelf assembly (60) slidably extends through the side opening (67) of the cabinet frame (32), and has a first position in which the shelf assembly (60) is received within the first cavity and a second position in which the shelf assembly (60) projects outwardly from a side of the cabinet frame (32). A spout passage (18) extend s through the aperture (at 18) in the mirror (20) and emits a stream of water. A control valve (46) can be mounted to the cabinet frame (32) to control the flow of water from a supply to the spout (18).
Patent CA-2465296-A1 (CA)
Inventor: KOCH STEFAN
IPC: H01L25/18
Filed: 2002-10-28
Abstract: A bondwire transition arrangement for interconnecting a signal port (12) on one IC (10) of a multichip module with a signal port (13) on another, adjacent, IC (11) of the same module employs a distributed signal-transition process in which the signal on one port (12) appears as subsignals at tappin g points along a series transmission-line segment arrangement (30) between tha t port and ground (33) on the same IC (10) and the subsignals are recombined along a second series transmission-line segment arrangement (31) connected between the other port (13) and ground (34) on the other IC (11). Spatially corresponding tapping points are interconnected via bondwires (35).
Patent CA-2466400-A1 (CA)
Inventor: BALDWIN GARY G
IPC: A63F3/06
Filed: 2004-05-05
Abstract: A scratch off lottery ticket comprising a casino sponsor. A first ticket portion is dedicated to a game of chance traditionally found on scratch off lottery tickets. A second ticket portion is dedicated to prizes associated with the casino sponsor. Prizes include free casino play, drawing entries and discounted casino amenities.  Prizes are redeemed at the casino location thereby increasing casino traffic. Any free play may be redeemed by inserting the winning ticket into a game device at the casino location. The ticket is a marketing tool for both the lottery and casino. A lottery may also sponsor an entire ticket and offer game credits redeemable on game devices provided by the lottery. Play of the game devices is tracked so that players accumulate points which are redeemed for lottery supplied merchandise. Winning and non winning lottery tickets may also facilitate bonus play of corresponding game devices.
Patent CA-2466722-A1 (CA)
Inventor: BIERL JAMES FRANKLIN
IPC: A01B71/04
Filed: 2004-05-07
Abstract: A maintenance free repetitive sealing system for a disk blade bearing hub utilizing an integrated system of components to seat and protect the primary bearing seal. The blade side of the spindle includes a hub overlap portion which deflects dirt, keeps large debris out, and prevents wrapping. A plastic seal protector keeps dirt and debris from pushing directly into external seal lips of a multiple lip seal. The lip seal provides positive sealing and is backed up by a grease layer barrier. The hub overlap, plastic seal protector, and grease barrier protect the bearing seal. The back side of the bearing hub is positively sealed with a protected O-ring and dust cap combination. The cap combination also protects the blade mounting hardware threads and nut.
Patent CA-2466971-A1 (CA)
Title: Benzimidazol- or indol-aminoacetonitrile derivatives for parasite control
Inventor: GOEBEL THOMAS
IPC: A61P33/10
Filed: 2002-11-13
Abstract: The invention relates to compounds of the general formula (I), wherein R1, R 2, R3, R4, R5, R6, R7, X, Y and a have the significances given in claim 1, and optionally the enantiomers thereof. The active ingredients have advantageous pesticidal properties. They are especially suitable for controlling parasite s on warm-blooded animals.
Patent CA-2467606-A1 (CA)
Inventor: VON HAAS GERNOT
IPC: B27N3/08
Filed: 2004-05-18
Abstract: The invention relates to a process for the production of pellets from pulverized feedstock, such as lignocellulose material and/or other combustible material for firing in fireplaces, and wherein the feedstock is introduced into openings in a die and compressed into pellets therein. The invention is characterized in that the charging of the die with feedstock and the compaction of the feedstock into pellets is effected in the die section of a multi-platen press with rams plunging into the many openings of the die, and in that after compaction the die is raised up with the force plate and additionally run up against the force plate, by which means the finished pellet is ejected from the die and then pushed out from the die section into a container by means of an ejection device. The invention further describes an installation for carrying out the process, consisting of a charging device and a multi-platen press.
Patent CA-2467891-A1 (CA)
Title: Apparatus and method for reproducing video contents
Inventor: JUN SUNG BAE
IPC: G11B27/28
Filed: 2004-05-21
Abstract: A method for reproducing video contents includes the steps of: selecting a reproduction shot from video contents, based on a current location information and a shot index information; determining a reproduction section from the selected reproduction shot; and reproducing the determined reproduction section. After the determined reproduction section is reproduced, the above processes are repeated to next reproduction shots. The repetitive processes are performed all over the video contents until the user requests a reproduction change.
Patent CA-2476658-A1 (CA)
Title: Process to prepare and isolate geldanamycin
Inventor: SALMAN OMAR A
IPC: C07D225/06
Filed: 2003-02-14
Abstract: The present invention relates to a process of preparing geldanamycin by culturing Streptomyces hygroscopicus in an aqueous nutrient medium. The aqueous nutrient medium can comprise starch, a starch conversion enzyme, an assimilable source of protein and optionally a further assimilable source of carbon or can comprise an assimilable source of carbon and an assimilable source of protein. The present invention also relates to a process for the isolation and purification of geldanamycin.
Patent CA-2479298-A1 (CA)
Title: Hemodynamic management using aortic pulse pressure and flow
Inventor: PINSKY MICHAEL R
IPC: A61B5/021
Filed: 2003-03-13
Abstract: A treatment algorithm for managing hemodynamically unstable patients is provided. Specifically, measurements of arterial pressure and stroke volume can be used to calculate pulse pressure variation, stroke volume variation, mean arterial pressure, elastance and cardiac power, the values of which guide treatment decisions and allow optimal management of critically ill patients.  In an additional embodiment, a computer system implementing the treatment algorithm is provided.
Patent CA-2481342-A1 (CA)
Inventor: VORHIES JAMES FRANCIS
IPC: G08C17/02
Filed: 2004-09-13
Abstract: Tube-type animal trap systems for the humane non-injurious, non-invasive trapping of animals, and to methods and systems for electronic remote trap monitoring and management. The invention includes mechanical and electric/electronic, tube-type traps, and to electronic data communications systems that enable remote monitoring of the status of any type of trap (e.g., is the trap tripped or not). Computer systems at a remote home base permit simultaneous management of multiple traps in the field, including enabling management via the Internet.
Patent CA-2481450-A1 (CA)
Title: Remote engine stop/start system with backup motor control
Inventor: BELL JOSEPH A
IPC: B66F11/04
Filed: 2004-09-13
Abstract: Hydraulically actuated aerial lift units for trucks typically have a primary hydraulic pump system driven by the vehicle's engine or by an electric motor. An actuation system accessible to a worker suspended by the aerial lift unit allows the worker to cycle the vehicle's engine on and off and, on vehicles so equipped, activate the backup motor for towering the aerial lift unit.
Patent CA-2483069-A1 (CA)
Inventor: LU YI
IPC: C12Q1/68
Filed: 2003-03-18
Abstract: A novel biosensor comprises at least one fluorophore and at least two quenchers, and is capable of selectively and specifically detecting the presence of an ion in the presence of other ions.