baber/WOPTO huggingface dataset:
Patent PT-751957-E (PT)
Inventor: ANDERTON STEPHEN MARK
IPC: A61K38/08
Filed: 1995-03-21
Abstract: Peptides are provided which are useful for protection against or treatment of an inflammatory disease, including autoimmune diseases, such as diabetes, arthritic diseases, atherosclerosis, multiple sclerosis, myasthenia gravis, or inflammatory responses due to tumour or transplant rejection. The peptides contain a part of the aminoacid sequence of a microbial protein having a conserved mammalian stress protein homologue, wherein the overall aminoacid sequence identity between the microbial and the mammalian homologues is at least 25 %, and the sequence identity between the microbial and the mammalian homologues of an area of at least 75 consecutive aminoacids is at least 30 %, said part comprising at least 5 aminoacids which are in the same relative position as the same aminoacids in a T cell epitope of said stress protein, which epitope contains at least 4 consecutive aminoacids which are identical with the corresponding mammalian stress protein aminoacids. Nucleotide sequences, expression systems, antibodies and pharmaceutical and diagnostic compositions derived from these peptides are provided as well.
Patent PT-759995-E (PT)
Inventor: GHEYSEN DIRK R
IPC: A61K38/00
Filed: 1995-05-11
Abstract: A fusion protein comprising a portion of a glycoprotein of HCMV fused to a portion of a glycoprotein of HSV is described.
Patent PT-848738-E (PT)
Inventor: GORBATY MARTIN LEO
IPC: E01C7/26
Filed: 1996-09-04
Abstract: The present invention provides a method of making storage-stable road paving binders by blending a minor amount of an unsaturated polymer (e.g., having at least one diene monomer) with a major amount of asphalt at an elevated temperature such that the components are sufficiently fluid to blend; treating the asphalt-polymer blend with a sulfonating agent; and stripping the treated asphalt-polymer blend at an elevated temperature with sufficient stripping gas to remove strippable sulfur moieties and to stabilize the resulting stripped, treated blend. The invention also provides asphaltic compositions made by the method. The asphaltic compositions are useful as binders in road paving applications.
Patent PT-902684-E (PT)
Inventor: KENNIS LUDO EDMOND JOSEPHINE
IPC: A61K31/54
Filed: 1997-05-15
Abstract: PCT No. PCT/EP97/02710 Sec. 371 Date Nov. 9, 1998 Sec. 102(e) Date Nov. 9, 1998 PCT Filed May 15, 1997 PCT Pub. No. WO97/44040 PCT Pub. Date Nov. 27, 1997This invention concerns the compounds of formula the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Alk is C1-6alkanediyl; R1 is hydrogen, C1-6alkyl, aryl or aryl C1-6alkyl; R2, R3 and R4 are each independently selected from hydrogen, halo, hydroxy, nitro, cyano, C1-6alkyl, C1-6alkyloxy, trifluoromethyl, C1-6alkylthio, mercapto, amino, mono- and di(C1-6alkyl)amino, carboxyl, C1-6alkyloxycarbonyl or C1-6alkylcarbonyl; R5 is hydrogen, C1-6alkyl, phenyl or phenylC1-6alkyl; R6 is hydrogen, C1-6alkyl, C1-6alkyloxy, C1-6alkylthio, or a radical of formula -NR8R9, wherein R8 and R9 are each independently selected from hydrogen, C1-6alkyl, phenyl or phenylC1-6alkyl; R7 is hydrogen or C1-6alkyl; or R6 and R7 taken together may form a bivalent radical of formula -R6-R7-; having central dopamine and serotonin antogonistic activity; their preparation, compositions containing them and their use as a medicine.
Patent PT-880964-E (PT)
Inventor: JOHNSON BRIAN FRANK
IPC: A61K31/496
Filed: 1998-05-01
Abstract: This invention relates to the use of aldose reductase inhibitors in the treatment, prevention or reversal of diabetic cardiomyopathy in a human subject.
Patent PT-1059862-E (PT)
Inventor: FIELDWICK JOHN EDWARD
IPC: A47B3/091
Filed: 1999-02-12
Abstract: A folding table (2) of robust construction having a reinforced picture-frame edge and underside elongate chassis members (24, 26) running along the length thereof, the chassis member (26) pivotally supporting two pairs of legs (6) and opposed track elements (40, 46) associated with each pair of legs. The track elements (40, 46) accommodate followers (50) attached to opposite ends (52, 53) of a connecting element (52) to which are fixedly secured legs (56, 58) of a support frame (54), legs (56, 58) of which pivotally connect the connecting element (52) to the legs (6) so that movement of the followers (50) in the track elements causes movement of the pairs of legs (6) between a first inoperative position and a second operative position. Latching members (70) are provided to lock each pair of legs (6) in one or other of their inoperative and operative positions and damper members (90, 140) are provided on each leg (32, 36) to prevent rapid movement of legs (32, 36) between said positions.
Patent PT-1056929-E (PT)
Inventor: VADING KJELL
IPC: F04C2/344
Filed: 1999-02-19
Abstract: A rotary-piston machine (10) comprising a housing (5) having a cavity (9), a rotor (2) received in the housing (5), which rotor (2) having a rotor axis (A) and a peripheral surface (21), inlet and outlet passages (3, 4) in communication with said cavity (9), one or more vanes (1) radially slideable received in slots (11) in the rotor (2), each vane (1) extending radially from the internal surface (20) of the housing (5) to the rotor axis (A), and at least one working chamber (9a) being part of the cavity (9) and is defined by the internal surface (20) of the housing (5), the peripheral surface (21) of the rotor (2) and the side surface of at least one vane (1). Each vane (1) is articulated connected about an axis (C) to one end of a control arm (7) and is in the other end pivotable journalled in a fixed axle shaft (8) having a central axis (B) being coincident with the axis extending centrally through the cavity (9) of the housing (5), which axis (B) extend in parallel with and spaced (d) from the rotor axis (A), and the rotor (2) proper constitute the unit for power take off or power input.
Patent PT-1075480-E (PT)
Inventor: BERGLUND RICHARD ALAN
IPC: C07C45/61
Filed: 1999-03-15
Abstract: The invention is directed to the process of purifying 4'-chloro-4-biphenylcarboxaldehyde.
Patent PT-1121382-E (PT)
Inventor: ADRIAN WHITTY
IPC: C12N15/09
Filed: 1999-10-15
Abstract: A fusion polypeptide is described having the amino acid sequence X-Y-Z, or portion thereof, comprising the amino acid sequence of a glycosylated interferon-beta (X); Y is an optional linker moiety; and Z is a polypeptide comprising at least a portion of a polypeptide other than glycosylated interferon-beta. It is preferred that X is human interferon-beta-1a. Mutants of interferon-beta-1a are also described.
Patent IE-890136-L (IE)
Title: 4-alkyl-1,4-dihydropyridines with PAF-antagonist activity
IPC: A61P37/08
Filed: 1989-01-18
Abstract: 4-alkyl-1,4-dihydropyridines with activity antagonistic of the PAF-"aceter" of formula (I) are described, in which R is a saturated alkyl chain C1-2; R' is a saturated or unsaturated C1-16 lineal, branched or cyclic chain that can be interrupted by an oxygen atom and can also represent a 2-(N-morpholine) ethyl group; n is 2 or 3; X is oxygen, sulphur or SO2; Ar represents an aromatic ring that cannot be phenyl when X=S and n=2. The compounds (I) can be prepared (a) by reaction of (II) with (III) and with (IV); or (b) by reacting (V) with (VI) and (IV); or (c) by reaction of (VII) with (VI). In these formulas the different radicals have the meaning given above. Compounds of formula (I) are used for the treatment of pathologic states and disorders in which the PAF-"aceter" participates, being used, for example, in treatment of inflammatory processes, psoriasis, glomerulitis, transplant rejection, acute and chronic bronchitis, bronchial asthma, states of shock and allergies Likewise it is used for the treatment of pathologic states and disorders in which it is necessary to stimulate the cellular immunity such as in immunodeficient syndromes and other situations in which the defense capacity is reduced. <CHEM> s
[EP0531598A1]
Patent IE-35060-L (IE)
Title: Fabricating photomasks
IPC: G03F1/54
Filed: 1971-04-14
Abstract: 1340604 Iron oxide WESTERN ELECTRIC CO Inc 19 April 1971 [17 April 1970] 26732/71 Heading C1A [Also in Division G2] Iron oxide having a botryoidal morphology is vapour deposited on a substrate heated at 100 -160‹ C. from an iron compound (especially iron pentacarbonyl) which has been thermally decomposed in an oxidizing or inert medium.
Patent IE-34193-L (IE)
Title: Hydrocarbon conversion catalyst.
IPC: C10G47/14
Filed: 1970-05-01
Abstract: 1305133 Reforming naphtha UNIVERSAL OIL PRODUCTS CO 1 May 1970 [28 May 1969] 21028/70 Heading C5E [Also in Division B1] Hydrocarbons are converted by contact with H 2 at elevated temperature and pressure in the presence of a catalyst comprising 0À01-2À0 wt. per cent of a platinum group metal which is substantially all in elemental form, 0À01-5À0 wt. per cent of germanium which is substantially all in a higher oxidation state than the metal, 0À5-10 wt. per cent of a halogen and a porous carrier. In examples a Pt-Ge-Cl on γ-alumina catalyst is used in the reforming of a heavy naphtha to give a C 5+ product at 517-566‹C., LHSV of 1À5-3À0, 6À8-34 atm. g. and a molar ratio of H 2 : hydrocarbon of 8-10 : 1.
[GB1305133A]
Patent IE-800698-L (IE)
Title: Preparation of mixtures for use in electrode production.
IPC: C25C3/12
Filed: 1980-04-03
Abstract: A mixture which is used for the manufacture of electrodes and comprises dry material and electrode binding agent. The mixture is prepared in a system which is at least in part dust and gastight and such that the mixture is simultaneously stirred up or fluidized, degassed and homogenized, and treated thermally. In the course of such treatment further additions can be made to the mixture. The described procedure takes place mainly in mixers operating continuously or discontinuously, various arrangements and designs of mixer being possible. Fundamental to the thermal treatment is that the mixture can be cooled in a mixer such that the coolant vaporizes completely during the mixing. The thermal treatment is regulated by way of given operational parameters.
[US4428679A]
Patent IE-41140-L (IE)
Title: Furoic amide derivatives.
IPC: A01N43/08
Filed: 1975-04-02
Abstract: 1448810 Furan derivatives CIBA-GEIGY AG 1 April 1975 [2 April 1974 10 Feb 1975] 13332/75 Heading C2C The invention comprises compounds of the Formula (I) in which R is H or methyl. They may be prepared by (a) acylating a compound of Formula (II) with furan (2)-carboxylic acid or an acid halide, anhydride or ester thereof, or (b) reacting a compound of Formula (III) with either an α-halopropionic acid methyl ester in the presence of an alkali metal carbonate, or with butyl lithium or sodium hydride to give the corresponding alkali metal salt, followed by reaction with an α-halopropionic acid methyl ester. The enantiomeric D-form of the compound of Formula (I) may be prepared by reacting the racemic compound of Formula (IV) in known manner with a nitrogen-containing optically active base to give the corresponding salt followed by fractional crystallization and liberation of the acid of Formula IV which is enriched with the optical D-antipode. The D- form of the ester of Formula (II) may then be prepared in conventional manner from the D form of the acid of Formula (IV), followed by acylation as in step (a) above, to give the D- form of the compound of Formula (I). The D- form of the acid of Formula (IV) may also be prepared by replacing the hydroxy group in L(+) lactic acid by halogen and reacting this product with 2,6-dimethylaniline or 2,3,6-trimethylaniline with reversal of the configuration. The compounds of Formula (II) may be prepared by reacting 2,6-dimethylaniline or 2,3,6- trimethylaniline with 2-bromopropionic acid methyl ester. The compounds of Formula (I) are used in fungicidal compositions.
[GB1448810A]
Patent IE-40314-L (IE)
Title: Prostaglandin intermediates
IPC: C07F7/18
Filed: 1974-04-11
Abstract: Novel prostaglandin intermediates and process for the production thereof. Compounds, and process for the production thereof, useful in the production of (dl)-[1 alpha -hydroxy-3 beta -(35-tetrahydropyranyloxy-trans-1-octenyl)-4 alpha -tetrahydropyranyloxycyclopent-1 alpha -yl] acetaldehyde hemiacetal and [1 alpha -hydroxy-3 beta -(3S-tetrahydropyranyloxy-trans-1-octenyl)-4 alpha -tetrahydropyranyloxycyclopent-1 alpha -yl] acetaldehyde hemiacetal.
[US3886185A]
Patent IE-820831-L (IE)
Title: Preparation of fluoromethylpyridines
IPC: C07D213/61
Filed: 1982-04-07
Abstract: Fluoromethylpyridines of the formula:  <IMAGE>  wherein the group FnH3-nC- may be ortho, meta or para to the ring nitrogen atom, n is 1, 2 or 3, m is 1 to 4, X is Cl, Br, I or F and, when m is 2, 3 or 4 the substituents represented by X may be the same or different, at least one X being ortho or para to the FnH3-nC- group, are prepared by reacting a compound of the formula:  <IMAGE>  wherein Y is Cl, Br, I or F and m is 1 to 4, with potassium fluoride in a polar aprotic solvent under substantially anhydrous conditions. These fluoromethylpyridines are useful as intermediates for herbicides. 3,4,5-trifluoro-2-trifluoromethylpyridine and 2,6-difluoro-3-difluoromethylpyridine are novel compunds.
Patent IE-34347-L (IE)
Title: Penicillin composition
IPC: C07D499/00
Filed: 1970-06-29
Abstract: 1321815 Oral penicillin compositions BEECHAM GROUP Ltd 29 June 1970 [3 July 1969] 33539/69 Heading A5B Novel orally administrable pharmaceutical compositions having antibiotic activity against Gram-positive and -negative bacteria comprise a conventional pharmaceutical carrier and a penicillin of formula: or a non-toxic salt thereof, wherein R is a phenyl group and R' is a C 2 -C 5 alkyl group, a tetrahydropyranyl group, a thienyl group or a thienylmethyl group. Suitable salts are those of Na, K, Ca, Al, ammonium or substituted ammonium.
[GB1321815A]
Patent FI-811529-L (FI)
Inventor: ALLAIS ANDRE
IPC: C07D215/56
Filed: 1981-05-18
Abstract: Novel compounds of the formula    <IMAGE>  I'  wherein X is in the 5,6,7 or 8 position and is selected from the group consisting of hydrogen, halogen, alkyl of 1 to 5 carbon atoms, alkoxy of 1 to 4 carbon atoms, CF3O-, CF3S- and CF3-, R1' is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, R2' is selected from the group consisting of hydrogen or an optionally unsaturated ring able to contain one or more heteroatoms of the group consisting of -S-, -O- and -N- optionally substituted with one or more members of the group consisting of (a) halogens, (b) alkyl of 1 to 4 carbon atoms optionally substituted with NH2, -NHAlK or -N-(AlK)2 and AlK is alkyl of 1 to 3 carbon atoms, (c) phenyl, (d) alkoxy of 1 to 4 carbon atoms, (e) -OH, (f) -CF3 and (g) -NO2 or R1' and R2' together with the nitrogen atom to which they are attached form an optionally unsaturated ring, the said ring then being connected to the nitrogen atom by a double bond, R3 is selected from the group consisting of hydrogen, halogen and alkyl of 1 to 4 carbon atoms, R4 is selected from the group consisting of hydrogen and halogen, R5 is a halogen with the proviso that R3, R4 and R5 can not all be fluorine and R6 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms and an acyl of an organic carboxylic acid of 2 to 8 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts and their salts with non-toxic, pharmaceutically acceptable bases having a remarkable analgesic activity, a very weak anti-inflammatory activity and a good tolerance by the gastrointestinal system and their preparation and their intermediates.
Patent FI-811661-L (FI)
Inventor: HENDRICKX JOHANNES WILHELMUS J
IPC: F24D3/10
Filed: 1981-05-29
Abstract: Fastening of a web of elastomeric material to an article without providing holes in the web, or clamping a thickened portion of the web, or glueing, or vulcanizing, by placing the web (2) on a flange (1) of the article which is provided with one or more inwardly tapered recesses, and by placing a counter-member (3) on the web (2), the countermember (3) having a complementary appearance with regard to the flange (1). 
<??>The invention is particularly suited for expansion tanks and tyre valves.
Patent FI-821250-L (FI)
Inventor: ERMERT WOLFGANG
IPC: B32B27/08
Filed: 1982-04-07
Abstract: The invention relates to composite packing films shrinkable by deep drawing and consisting of at least one copolyamide layer containing at least 50% by weight of  epsilon -caprolactam units and at least one heat-sealable layer, and optionally, an adhesion-promoting layer.
Patent FI-832433-L (FI)
Inventor: VERWER ANDREAS NICOLAAS JACOBU
IPC: C08J7/04
Filed: 1983-07-01
Abstract: Powered coating compositions composed of a bonding agent of unsaturated polyester resin and hardening catalyst and bonding agent. The composition, prior to the addition of any catalyst, is a mixture of (I) about 85 to 100 weight percent of a mixture of polyester resins, which itself comprises about 70 to about 98 weight percent of a first polyester resin composed of at least one unsaturated polyester resin, the first resin: (i) having a melting point of at least 70 DEG C as measured with the ring-and-ball method, (ii) occurring as a free-flowing powder at temperatures of up to 25 DEG C, (iii) having a degree of unsaturation of at least 15 calculated as weight percent maleic anhydride to the total polyester, and (iv) yielding a product having an elongation at break of at most 10% upon curing with styrene; (b) about 2 to about 30 weigth percent of a second polyester resin composed primarily of at least one unsaturated polyester resin, the second resin yielding a product having an elongation at break of at least 50% upon curing with styrene and the amount and the melting point of the second resing being such that a mixture of the first and the second resin has a melting point by the ring-and-ball method of at least 40 DEG C; and (II) about 0 to about 15 weight percent relative to the first and second resins of one or more copolymerizable monomers and/or prepolymers having a boiling point of at least 200 DEG C. Such compositions are very suitable for preparing a top coat using the in-mold coating technique.
Patent FI-851360-L (FI)
Inventor: WHITE JAMES WILLIAM
IPC: C08L83/08
Filed: 1985-04-03
Abstract: Compositions curable by radiation e.g. UV radiation are disclosed and claimed which comprise an organosiloxane having at least two siloxane units including groups -RSH, an organosiloxane having at least two siloxane units including ethyl- cyclohexenyl groups, and a photoinitiator. The compositions cure on exposure to UV radiation and may be used to produce on a variety of substrates coatings which are of reduced odour. Also disclosed and claimed is a method of treating a substrate which comprises applying a coating of such compositions and irradiating the coating. Examples given refer to production of coatings on paper substrates to provide cured coatings.
Patent IE-831024-L (IE)
Title: Human tissue plasminogen activator
IPC: C12R1/92
Filed: 1983-05-04
Abstract: Human tissue plasminogen activator (t-PA) is produced in useful quantities using recombinant techniques. This invention thus enables production of t-PA free of contaminants associated with it in its native cellular environment. Methods, expression vehicles and various host cells useful in its production are also disclosed.
[EP0093619A1]
Patent IE-851035-L (IE)
Title: Contrast agents for nmr imaging in diagnostics
IPC: A61K/
Filed: 1985-04-23
Abstract: An agent for contrast enhancement in nuclear magnetic resonance imaging comprises micellular particles such as phospholipid vesicles associated with or enclosing a paramagnetic material. The particles may be formulated with an agent, such as cholesterol, to promote vesicle stability and water exchange across the vesicle bilayer. The vesicles may or may not have antibodies or other cell recognition targeting agents attached to the surface to provide specific targeting. The vesicles provide enhanced target specificity, reduced burden of toxic contrast material and amplified contrast enhancement.
Patent IE-781059-L (IE)
Title: Polysiloxane polymer, contact lens
IPC: C08F2/00
Filed: 1978-05-26
Abstract: Polymers or copolymers derived from a polyorganosiloxane monomer bonded terminally to a polymerisable, activated, unsaturated group via a divalent hydrocarbon group are particularly suitable for contact lenses having significantly increased oxygen-transport capacity. The conversion of the polymer compositions into contact lenses is carried out, inter alia, by centrifugal casting.
[GB1604519A]
Patent IE-781159-L (IE)
Title: Chlorination or chlorosulphonation of polyethylene
IPC: C08F8/20
Filed: 1978-06-07
Abstract: A process for chlorinating or chlorosulfonating polyethylene comprising dissolving polyethylene in a solvent that is a mixture of methylene chloride and trichloro-fluoromethane in a weight ratio of 0.3-1.6, reacting the resultant solution with sulfuryl chloride under pressure to maintain reactants, the resulting chlorinated or chlorosulfonated polyethylene and product gases in a single liquid phase, reducing the pressure on or increasing the temperature of the single liquid phase of chlorinated or chlorosulfonated polyethylene and solvent to form two liquid phases, one a polymer-rich phase and the other a solvent-rich phase, and separating the phases.[EP0000052A1]
Patent IE-841201-L (IE)
Title: Prolonged release pharmaceutical formulation
IPC: A61K31/74
Filed: 1984-05-15
Abstract: A formulation of a drug wherein the drug is present as a coated, drug-resin complex suspended in a liquid carrier which carrier also contains a second ionic component bearing the same charge as the coated complexed drug, the second ionic component being present as an uncoated, insoluble drug-resin complex.
Patent IE-821575-L (IE)
Title: Electromechanical switch for telephone
IPC: H04M1/08
Filed: 1982-06-29
Abstract: 1. An electro-mechanical switch for telephone apparatus, comprising a base part (1) made of insulating material and in which contact springs (2) in the form of leaf springs are arranged one beside another in parallel spaced planes so as to cover one another as regards their outline, the contact springs being in each case firmly clamped in the base part (1) at one end (3) and at the other end (4) can be elastically deflected at right angles to their plane of orientation by means of a control slide (7) which is guided so as to be linearly movable on the base part (1), characterised in that on the base part (1) the guide path of the control slide (7) is oriented parallel to the longitudinal direction of the contact springs (2) and the control slide (7) is provided with rigid, essentially parallel bars (8) which engage between the contact springs, parallel to the contact springs (2) from the deflectable ends thereof ; that on their side surfaces (11) which face towards the deflectable contact springs (2), the control bars (8) are in each case provided with both a sloped contact surface (13), which protrudes from the plane of the respective lateral surface, and also with a deflecting surface (12) which adjoins the contact surface and extends at a constant distance from the lateral starting plane (11) ; that in the vicinity of their free ends (4), the deflectable contact springs (2) are in each case provided with a driving cam (14) which protrudes at right angles to the deflecting surface (12) of the adjacent control bar (8), and have an elastic prestress (P1) which is oriented in the direction of the driving cam ; and that adjacent the free ends (4) of the deflectable contact springs (2), in each case from the side of the deflecting surface (12) of the adjacent side surface of the control bar (8), a counter-contact (6) is provided which has a parallel-extending, rigid contact surface and is fixed to the base part (1).
Patent IE-811740-L (IE)
Title: Elastic bandages
IPC: A61L15/42
Filed: 1981-07-30
Abstract: Moisture vapor transmitting elastic bandages which comprise an inner layer of fabric and an outer layer of fabric bonded to a central layer characterized in that the central layer comprises an elastomeric film are described.
[US4414970A]