baber/WOPTO huggingface dataset:
Patent SG-11201811506U-A (SG)
Title: Process of preparing a peptide epoxyketone immunoproteasome inhibitor, and precursors thereof
Inventor: JOHNSON HENRY
IPC: C07D303/46
Filed: 2017-06-29
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111101111 0 1110101011111 011101 0 011111111111111H1111111011111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\" WO 2018/005781 Al 04 January 2018 (04.01.2018) W I PO I PCT (51) International Patent Classification: C07D 295/15 (2006.01) C07D 303/46 (2006.01) Published: C07D 303/12 (2006.01) CO7C 69/612 (2006.01) — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the (21) International Application Number: claims and to be republished in the event of receipt of PCT/US2017/039975 amendments (Rule 48.2(h)) (22) International Filing Date: 29 June 2017 (29.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/356,178 29 June 2016 (29.06.2016) US (71) Applicant: KEZAR LIFE SCIENCES [US/US]; 300 Utah Ave, Suite 105, South San Francisco, CA 94080 (US). (72) Inventors: JOHNSON, Henry; 360 Hazel Avenue, San Bruno, CA 94066 (US). DALZIEL, Sean; 1220 Balboa Avenue, Burlington, CA 94010 (US). MCMINN, Dustin; 255 Kent Road, Pacifica, CA 94044 (US). (74) Agent: BERKOWSKI, Kimberly L. et al.; Marshall, Ger- = stein & Borun Llp, 233 S. Wacker Drive, 6300 Willis Tow- er, Chicago, IL 60606-6357 (US). = (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, _ DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = = = = = _ Designated States (unless otherwise indicated, for every — (84) _ _ kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). = = = = — = 1-1 (54) Title: PROCESS OF PREPARING A PEPTIDE EPDXYKETONE IMMUNOPROTEASOME INHIBITOR, AND PRE- I l CURSORS THEREOF GC IN (57) : Disclosed herein are methods for preparing kr) il [(2S,3R)-N-[(25)-3-(cyclopent- 1-en-l-y1)-1-[(2R)-2-methyloxi- 0 - ' - '\"i 0 ran-2-yl] -1 -oxopropan-2-y1]-3-hydroxy-3-(4-methoxypheny1)-2- H --.... 1-1 IL)-L N ,,, N (G) [(2S)-2-[2-(morpholin-4-yl)acetamido]propanamido]propanamide H (compound \"G\"): and precursors thereof. 0 0 ei AMIlk HO so OM e
Patent SG-11201901431P-A (SG)
Title: Novel salt of (r)-(1-methylpyrrolidine-3-yl)methyl(3'-chloro-4'-fluoro-[1,1'-biphenyl]-2-yl)carbamate and a crystal form thereof
Inventor: KWAK WOO YOUNG
IPC: C07D207/06
Filed: 2016-08-26
Abstract: NOVEL SALT OF (R)-(1-METHYLPYRROLIDINE-3-YL)METHYL(3'-CHLORO-4'- FLUORO-[1,1'-BIPHENYL]-2-YL)CARBAMATE AND A CRYSTAL FORM THEREOF The present invention relates to a novel salt of (R )-(1-methylpyrrolidine-3- yl)methyl(3'-chloro-4'-fluoro-[1,1'-biphenyl]-2-yl) carbamate and a crystal form thereof. Also, the novel salt of (R)-(1-methylpyrro lidine-3-yl)methyl(3'-chloro-4'- fluoro-[1,1'-biphenyl]-2-yl)carbamate and the cryst al form thereof according to examples of the present invention have remarkably e xcellent stability, hygroscopicity and solubility. [Figure 1]
Patent IS-2869-B (IS)
Inventor: THURLIMANN BEAT
IPC: C07J1/00
Filed: 2002-10-01
Abstract: The invention relates to the use of fulvestrant in the treatment of breast cancer in patients who have previously been treated with an Selective Estrogen Receptor Modulator (SERM) and an aromatase inhibitor.
Patent AT-387723-B (AT)
Title: Method for producing a ski running-surface coating material for cross-country skis, and cross-country ski with such a running-surface coating material
IPC: A63C5/04
Filed: 1986-03-11
Granted: 1989-03-10
Abstract: To produce a strip-shaped or band-shaped running-surface coating material which is intended to form, in a central region of the sliding sole of a cross-country ski, the running-surface coating which is active there as a climbing aid, the starting material components, which are in each case present in the form of small particles or in powder form and consist of a vulcanized or cross-linked elastomer and a preferably thermoplastic material having greater hardness than this elastomer, are mixed evenly, and this mixture is then, under pressure and high temperature, sintered to form blocks or rounds, from which the strip-shaped or band-shaped coating material is then produced by a cutting operation, in particular by paring the sintered rounds. In this connection, the plastic particles having a greater hardness than the elastomer preferably consist at least predominantly of polypropylene.
Patent AT-406778-B (AT)
Inventor: DORNER FRIEDRICH
IPC: A61L2/00
Filed: 1996-04-09
Granted: 2000-09-25
Abstract: PCT No. PCT/AT97/00068 Sec. 371 Date Nov. 18, 1998 Sec. 102(e) Date Nov. 18, 1998 PCT Filed Apr. 8, 1997 PCT Pub. No. WO97/37686 PCT Pub. Date Oct. 16, 1997The invention relates to a method for the disintegration of any biologically active nucleic acid in a biological material, wherein a biologically active material is exposed or multiply exposed to laser beam to disintegrate essentially all biologically active nucleic acid in said biological material, while the biological integrity and activity of said biological material is maintained.
Patent AT-403678-B (AT)
IPC: B42D1/08
Filed: 1993-03-30
Granted: 1998-04-27
Abstract: A photograph album having a paper or board cover which has at least one middle part, at least its inside being coated with a layer of chlorine-free plastic and a plurality of transparent sleeves for receiving photographs being connected thereto and consisting of a possibly different chlorine-free plastic. <IMAGE>
Patent HU-195131-B (HU)
Inventor: POPLAVSKY ALBERT K
IPC: B05B7/28
Filed: 1986-01-21
Abstract: A találmány tárgya szivattyúaggregát szóróberendezésekhez, amelynek alternáló hajtóegysége (7) van, amelynek szemközti homlokfelületein egy-egy harmonikaszerü elemet (12) magába záró ház (11, 11’) van rögzítve, ahol a harmonikaszerű elem (12) külső felülete és a ház (11, 11’) belső felülete között belső üreg (17) van, továbbá az egyik házban (11, 11’) elrendezett harmonikaszerű elem (12) belső tere (16) nyomószelepen (15) keresztül nyomóvezetékkel (19), szívószelepen (14) keresztül pedig szívóvezetékkel (18) van összekötve, míg a harmonikaszerü elem (12) külső felülete és a ház (11,11’) belső felülete közötti belső üreg (17) kiegyenlítő töltőfolyadékkal van feltöltve. A javaslat lényege, hogy a másik házban (11) elrendezett harmonikaszerü elem (12) belső tere (16) nyomószelepen (15), illetve szívószelepen (14) keresztül ugyancsak a nyomóvezetékkel (19), illetve szívóvezetékkel (18) van összekötve, ahol a harmonikaszerű elem (12) külső felülete és a ház (11) belső felülete közötti belső üreg (17) kiegyenlítő töltőfolyadékkal van feltöltve, továbbá a hajtóegység (7) szemközti homlokfalaiban folyadékgyűjtő gyűrűs kamrák (20) vannak kiképezve, amelyek visszacsapó szelepen (22) keresztül a szemközti homlokfelülethez csatlakozó házban (11, 11’) elrendezett harmonikaszerű elem (12) és a ház (11, II’) belső fala közötti belső üreggel (17) vannak összekötve (2. ábra).  -1-
Patent HU-184769-B (HU)
Title: Process for preparing new d-homo-steroids
Inventor: ALIG LEO
IPC: A61K31/57
Filed: 1977-08-31
Abstract: Anti-inflammatory D-homosteroids of the formula <IMAGE> in which the dotted 1,2 bond denotes an optional C-C bond; R<6> denotes hydrogen, fluorine, chlorine or methyl; R<9> denotes hydrogen, fluorine or chlorine and R<17a> denotes hydroxyl or acyloxy, where R<9> is to be fluorine or chlorine if R<6> is hydrogen in a 17 alpha -hydroxy compound or R<6> is fluorine in a singly unsaturated 17a-hydroxy compound, are prepared by treating a corresponding 21-iodo-D-homosteroid with a reducing agent. A singly unsaturated D-homosteroid of the formula I can then be dehydrogenated to the doubly unsaturated D-homosteroid of the formula I, a 6-unsubstituted D-homosteroid of the formula I can be fluorinated or chlorinated in position 6, and a 17a alpha -hydroxy-D-homosteroid of the formula I can be acylated in position 17a alpha .
Patent HU-181796-B (HU)
Title: Process for liming of raw hides with respect of the environment
Inventor: FEKETE KALMAN
IPC: C14C1/06
Filed: 1981-03-12
Abstract: Environment-protecting method for the liming of raw hides, wherein, after an optional mechanical degreasing step, the hides are subjected to presoaking, chemical degreasing, washing, alkaline swelling and collapsing, enzymatic unhairing, plucking and liming, and the sulfide ions remaining in the liquor after liming are deactivated. According to the invention the raw hides are treated, prior to liming, with 0.05 to 0.50 % by weight of a proteolytic enzyme with an Anson-activity of 1.2 to 1.5 in a bath of a temperature not exceeding 35<o>C and a pH value not exceeding 12, thereafter the hides are subjected to hair-destruction liming with a lime liquor containing not more than 2.0 % by weight of disodium sulfide and/or sodium hydrogen sulfide, calculated for the weight of the raw hide, and the sulfide ions remaining in the lime liquor are oxidized directly in the liming vessel so that 100 % by weight of water and at least 0.04 % by weight of manganese sulfate are added to the used lime liquor in the presence of the limed hides, the hides are rotated in the liquor for at least 15 minutes, thereafter up to 1.0 % by weight of technical hydrogen peroxide are added, preferably in three portions at intervals of 10 minutes, to the liquor within an additional rotation period not exceeding 150 minutes.
Patent HU-199981-B (HU)
Inventor: AKOS GYOERGY
IPC: G02B26/10
Filed: 1988-02-12
Abstract: A találmány tárgya optikai elrendezés pásztázó lézersugaras készülékekhez, elsősorban lézeres méretellenőrzéshez, képletapogatáshoz és lézeres nyomtatáshoz. A találmány szerinti elrendezés tartalmaz párhuzamos fénynyalábot kibocsátó lézert (1), nyalábeltéritöt (2) és pásztázó gyújtólencsét (3), valamint a lézer (1) és nyalábeltéritő (2) közé beépített olyan konvergencia - divergencia beállító nyalábformálót (4), amely a működés során a nyalábeltéri tőre (2) mindig állandó átmérőjű fényfoltot vetít, a nyaláb táguló vagy szűkülő jellege azonban állítható. A találmány célszerű megvalósítási változatánál a konvergencia-divergencia állítás gyűjtőlencse (6) és szórólencse (5) egymáshoz képesti közelítésével vagy távolításával történik. (Jellemző ábra: 3. sz.)  HU 199981 A leírás terjedelme: 4 oldal, 2 rajz 5 ábra -1-
Patent SE-321168-B (SE)
Inventor: BERNABEO L
IPC: F42B8/04
Filed: 1966-01-25
Abstract: 1,122,418. Blank cartridges. GIULIO FIOCCHI S.p.A. 8 Dec., 1965 [26 Jan., 1965], No. 52114/65. Heading F3A.  A blank cartridge 4 for industrial and sporting use having a closure wad consisting of at least one integral peripheral flange 3<SP>1</SP> engaging the inner surface of the cartridge close to its open end and a transverse diaphragm which is, at least in part, of smaller thickness than the part of the flange adjacent the diaphragm. Weakening grooves, which may be annular or radial, may be formed in the diaphragm. The flange 3<SP>1</SP> may be tapered as shown or be of uniform thickness. The rim 4<SP>11</SP> of the cartirdge is bent over on itself in U-form around the flange 3<SP>1</SP> or may be simply bent over the flange as in Fig. 4 (not shown).
Patent AT-402717-B (AT)
Title: Interchangeable container which can be transferred from a railway vehicle to a road vehicle and vice versa
IPC: B60P1/64
Filed: 1993-05-27
Granted: 1997-08-25
Abstract: The invention relates to an interchangeable container 1 which can be transferred from a rail vehicle 2 to a road vehicle 3 and vice versa and can be loaded and unloaded from a loading ramp, the height of the loading face of the interchangeable container 1 corresponding, once it is loaded on these vehicles, to the ramp height in order to match standardised loading ramps. On the underside of the floor of the interchangeable container 1, strips 5 are arranged which run transversely with respect to the longitudinal extent of the interchangeable container 1. In order to receive these strips, the frame of the rail vehicle 2 is provided on its upper side with cut-outs 7 which are arranged at a distance which corresponds to the distance between the strips 5, and the frame 8 of the road vehicle 3 has a bent portion 9 corresponding to the height of the strips 5 in order to form a lower-lying frame section which has crossbeams 10, at a distance corresponding to the distance between the strips 5, for supporting the strips 5, holes for the engagement of spigots 11 and 12 or similar centring elements (container closure), which are attached in the recesses 7 of the frame 6 of the rail vehicle 2 or to the crossbeams 10 of the frame 8 of the road vehicle 3, being preferably provided in the strips 5. <IMAGE>
Patent AT-403596-B (AT)
Title: Building-wall covering
IPC: E04B1/41
Filed: 1989-06-19
Granted: 1998-03-25
Abstract: The anchoring means for a plaster base 9, which can be set in plaster, on the outside of an insulating-material layer 1 provided on a building wall 7 is arranged in the vertical joints of adjacent insulating panels. The anchoring means, with an obliquely running anchor part 3, also has a further anchor part 4, which runs perpendicularly to the building wall 7. The end regions 5, 6 of the two anchor parts 3, 4 butt against one another and are bent over upwards for installation. <IMAGE>
Patent AT-391889-B (AT)
Title: Device for the production of a yarn
IPC: D01H4/30
Filed: 1986-06-12
Granted: 1990-12-10
Abstract: In a device for the production of a yarn, having two spinning drums 1, 2 which are located close to one another and rotate in the same direction and which between them form a suction-controlled spinning gusset 4, with a fibre feed arrangement and with a take-up arrangement 7 for the yarn 6 twisted together in the spinning gusset 4 from the fibres which have been fed, so that, on the one hand, the advantage of binding free- flying enveloping fibres into the composite yarn structure can be combined with the advantage of positive guidance of these enveloping fibres and, on the other hand, a small proportion of enveloping fibres can be ensured, the fibre feed arrangement consists of a feeder roller 8 which precedes, on the end face, a spinning drum 1 rotating into the spinning gusset 4 and is capable of being driven in the yarn twisting direction and which has a suction-controlled circumferential region 12, leading into the spinning gusset 4, and on the spinning-drum side, axially next to this suction-controlled circumferential region 12, a suction zone 13 terminating at a distance in front of the spinning gusset 4. In the region of axial extent of this suction zone 13, above the spinning gusset 4, there is a transfer roller 16 which rotates in the opposite direction to the feeder roller 8 and which forms, after the suction zone 13 of the feeder roller 8, a suction stage 18, at the end of which a pressure roller 21 is arranged. <IMAGE>
Patent AT-407071-B (AT)
Inventor: KOGLER PETER DIPL ING
IPC: E21C27/24
Filed: 1996-12-04
Granted: 2000-12-27
Abstract: The invention relates to a device for damping vibrations in part-face cutting machines (1), comprising an extension arm (3) pivoting round two axes (5, 9) with cutting tools (7) rotationally fitted thereon. Said device has a hydraulic regulating drive mechanism (6) which is impinged upon by fluid via a valve arrangement. Sensors (13 or 14) are provided in order to detect vibrations, accelerations, load and/or position of the cutting arm (3) and which trigger a corresponding compensation of the regulating drive mechanism formed by the hydraulic cylinder piston units (6) by means of a control device (16). The position of the extension arm (3) is thus kept basically constant round the vertical rotational axis (9) when the swing gear swivels.
Patent DK-160266-B (DK)
Inventor: BORUP-NIELSEN LARS
IPC: E05D15/44
Filed: 1987-03-02
Abstract: The invention relates to a fitting for supporting the wing of a window in such a way that the wing can rotate about a horizontal or about a vertical axis of rotation in relation to the window frame. The fitting comprises a frame part in the form of a C-shaped guide rail (1) to be fastened to the frame, a sliding piece (2) longitudinally movable in the rail, a wing part in the form of a wing plate (3) to be fastened to the frame, a scissor arm (4) fastened rotatably both to the frame part (1) and to the wing part (3), a support plate (5) fastened rotatably both to the sliding piece (2) and to the scissor arm (4), and at least one link (6) fastened rotatably to the wing part. When the link (6) is also fastened rotatably to the support plate (5) and the distance between the two axes of rotation of the link (6) is so small that the wing plate always rests with a substantial part on the support plate (5) the fitting is capable of absorbing considerably higher loads than conventional fittings of this type. <IMAGE>
Patent DK-156899-B (DK)
Inventor: KASTNER GERHARD
IPC: A61K38/095
Filed: 1981-09-10
Abstract: A process for the preparation of phenylacetonitriles, carrying basic substituents, of the formula I    <IMAGE>  I  where R1, R2, R3, R4, R5, R6, R7 and R8 have the meanings given in the description, by reacting an aldehyde of the formula II    <IMAGE> II  with an amine of the formula III    <IMAGE> III
Patent DK-163485-B (DK)
Inventor: HENZE RAINER
IPC: B29C48/10
Filed: 1987-09-15
Abstract: A process of manufacturing a roll of continuous synthetic thermoplastic film consisting of extruded flat film or of extruded blow-formed and flattened tubular film in which the thickness of the film is measured over the width of the film. Any striplike portion which deviates in thickness from a means thickness of the film is adjusted. The temperatures of juxtaposed temperature control sectors or the width of those portions of the slot die or of the annular die from which said striplike portions have been extruded are adjustable. When a striplike longitudinal portion having a relatively large thickness is detected in the film, the film is subsequently extruded to have a corresponding portion which has a relatively small thickness within specified thickness limits and for a length such that the two portions as superimposed in the roll have an average thickness approximately equal to the mean film thickness.
Patent FI-53672-B (FI)
Inventor: BOWEN WILLIAM EDMUND
IPC: B29D23/20
Filed: 1972-11-28
Granted: 1978-03-31
Abstract: A method of welding a plastic end member to an unstepped, plastic tubular body which comprises positioning the end member within the body and then irradiating the area to be welded with a laser beam for a specified time sufficient to achieve the desired weld while simultaneously imparting relative rotational motion between the beam and the area to be welded.
Patent FI-60366-B (FI)
Inventor: BOSSE FRANK
IPC: B31B170/20
Filed: 1979-09-06
Granted: 1981-09-30
Abstract: Sacks are made from a web comprising a tube of stretched plastics tape fabric woven around a thermoplastic tubular film. The web is continuously fed to a storage device from which two-ply sack lengths are intermittently withdrawn and severed and provided with a stitched base seam. Each severing cut is made to extend through transverse strips of hot-melt adhesive which were applied to both sides of the fabric tube and cooled. After severing and prior to stitching through both plies, the inner ply is provided with a separate base seam by means of welding jaws.
Patent FI-70914-B (FI)
Inventor: LANGE WOLFGANG
IPC: A61L9/04
Filed: 1981-07-10
Granted: 1986-07-18
Abstract: The invention relates to a process producing porous powdery polymer particles. A homogeneous mixture having two components minimum, one a meltable polymer, the other fluid inert to the polymer, both forming a system having a range of complete miscibility and a miscibility gap are introduced to a bed of solid-substance particles, then cooling the mixture to below solidification of the polymer and comminuting the obtained cake-like mass. The polymer is separated then from the inert fluid and solid-like substance particles.
Patent FI-84424-B (FI)
Inventor: BECKER ERICH
IPC: A47B1/00
Filed: 1987-10-15
Granted: 1991-08-30
Abstract: In the table system, at least two adjacent table elements can be connected detachably via their opposite table top edges with the aid of at least one mechanical connection device. Of the essentially two-part connection device, a first main part contains a fastening lever which is built into the table top edge region of the one table element such that it can be swivelled out, whereas the second main part of the connection device, which is built into the table top edge region of the adjacent table element, is constructed for positive accommodation of the fastening lever and contains a securing element for the locking engagement between the first and second main parts. The assembly and dismantling of the individual table elements can be carried out quickly, reliably and without additional aids.
Patent FI-96768-B (FI)
Inventor: PIWINSKI JOHN J
IPC: C07D401/06
Filed: 1989-04-17
Granted: 1996-05-15
Abstract: Derivatives of benzo[5,6]cyclohepta pyridine, and pharmaceutically acceptable salts and solvates thereof are disclosed, which possess anti-allergic and anti-inflammatory activity. Methods for preparing and using the compounds are also described.
Patent FI-101475-B (FI)
Inventor: STERN ANNE
IPC: C07H21/04
Filed: 1990-05-30
Granted: 1998-06-30
Abstract: The tissue plasminogen activator (t-PA) derivative is not glycosylated and has the following amino-acid sequence: <IMAGE>
Patent FI-94372-B (FI)
Inventor: SUNDSTROEM INGE
IPC: F16B13/06
Filed: 1991-07-09
Granted: 1995-05-15
Abstract: PCT No. PCT/SE90/00009 Sec. 371 Date Jul. 3, 1991 Sec. 102(e) Date Jul. 3, 1991 PCT Filed Jan. 4, 1990 PCT Pub. No. WO90/08265 PCT Pub. Date Jul. 26, 1990.A fastening device in the form of a plug and a screw is adapted for installation in a blind bore of a thick wall or in a through hole in a thin wall. The plug is formed as an elongated body having a central longitudinal hole. The body has inner and outer end portions and two parallel slots extending longitudinally between the end portions to define four legs arranged circumferentially around the body. The legs diverge from the end portions to form an increasing diameter for the body which reaches a maximum at the center of the body. When the plug is inserted into a blind bore the legs are displaced inwardly to reduce the size of the central longitudinal hole so that when the screw is inserted into the plug, the screw will exert force on the legs to press the legs against the wall with strong radial forces. When the plug is inserted in a thin wall, threaded engagement between the screw and the inner end portion of the plug produces longitudinal displacement of the inner end portion and radial deformation of the legs to provide clamping pressure at the back of the wall at four distant locations.