Patent SG-11201806583X-A (SG)
Title: Compositions containing tucaresol or its analogs
Inventor: HUANG LAN
IPC: A61P35/00
Filed: 2017-02-06
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 1111111101111011101010111110101111101110111001110101111011011111101111011111 International Bureau ... .... ..Yjd ..... ...,/ (10) International Publication Number (43) International Publication Date WO 2017/139231 Al 17 August 2017 (17.08.2017) WIPO I PCT (51) International Patent Classification: A61K 31/277 (2006.01) A61K 31/24 (2006.01) A61K 31/235 (2006.01) A61K 31/216 (2006.01) A61K 31/20 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 62/292,763 8 February 2016 (71) Applicant: BEYONDSPRING INC. [US/US]; 28 Liberty Street, 39th Floor, New York, NY 10005 (US). (72) Inventors: HUANG, Lan; 28 (81) Designated States (unless otherwise indicated, for every A61K 31/192 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 31/41 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61K 31/506 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, A61K 39/395 (2006.01) DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, A61P 35/00 (2006.01) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, PCT/US2017/016740 NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, 6 February 2017 (06.02.2017) TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. English (84) Designated States (unless otherwise indicated, for every English kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (08.02.2016) US TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, PHARMACEUTICALS, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Liberty Street, 39th Floor, GW, KM, ML, MR, NE, SN, TD, TG). MOHANLAL, Ramon; 28 Published: New York, NY 10005 (US). — with international search report (Art. 21(3)) 28 Liberty Street, 39th Floor, Knobbe, Martens, Olson & 14th Floor, Irvine, CA — New York, NY 10005 (US). _ Liberty Street 39th Floor, LLOYD, George, Kenneth; = New York, NY 10005 (US). — (74) Agent: ARNO, Thomas, R.; = Bear, LLP, 2040 Main Street, 92614 (US). = = = = TUCARESOL OR ITS ANALOGS --0----- PD-1 Ab (54) Title: COMPOSITIONS CONTAINING = 1600— . --4-- PD-1 Ab +13P1 (Tucaresol) = --------- PD-1 Ab + CTLA4 Abs PDAb + CTLA4Ab + BPI ---A--• -1 = *p<0.05 vs. PD-1 Ab alone *pp, 0.01 vs. PD-1 Ab alone = 1000 — = o 1-1 11 0 M 0 ei tz. M ,-, IN Il (57) : Disclosed herein are compositions including a compound of formula (I) for treating cancer. Some embodiments relate 0 to methods of treating cancer by co N ject in need thereof. Some embodiments C plinabulin to a subject in need thereof. cancer by co-administering a compound of formula (I), one or more immune checkpoint inhibitor. 1 i 1 6 10 16 20 26 Days 76: -administering a compound of formula (I) and one or more immune checkpoint inhibitor to a sub - relate to methods of treating cancer by co-administering a compound of formula (I) and Some embodiments relate to methods of providing co-stimulation of T-cell activation against