Patent SG-11201906788X-A (SG)
Title: Factor ix fusion proteins and methods of making and using same
Inventor: VAN DER FLIER ARJAN
IPC: A61K38/00
Filed: 2018-01-31
Abstract: giAE KAE2811 Amino acid number 166 j 174 224 413 4 4 Sites selected - o a) E - o a) C 0 C C u_ co (7.) 0 E 0 c 2 to - 0 0 Q 0 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 09 August 2018 (09.08.2018) WIP0 I PCT omit VIII °nolo 010 Ho Em VIII °mono oimIE (10) International Publication Number WO 2018/144623 Al (51) International Patent Classification: A61K 38/00 (2006.01) Cl 2N 9/64 (2006.01) A61K 9/00 (2006.01) (21) International Application Number: PCT/US2018/016277 (22) International Filing Date: 31 January 2018 (31.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/452,826 31 January 2017 (31.01.2017) US (71) Applicant: BIOVERATIV THERAPEUTICS INC. [US/US]; 225 Second Avenue, Waltham, Massachusetts 02451 (US). (72) Inventors: VAN DER FLIER, Arjan; 32 Ibbetson Street #2, Somerville, Massachusetts 02143 (US). LIU, Zhigian; 5 Pocahontas Drive, Winchester, Massachusetts 01890 (US). LIGHT, David R.; 43 Park Street, Unit #16, Somerville, Massachusetts 02143 (US). CHHABRA, Ek- ta Seth; 1550 Worcester Road, Unit #128, Framingham, Massachusetts 01702 (US). LIU, Tongyao; 3 Buckman Drive, Lexington, Massachusetts 02421 (US). PETERS, Robert T.; 53 Parkinson Street, Needham, Massachusetts 02492 (US). KULMAN, John; 88 Creeley Road, Belmont, Massachusetts 02478 (US). ISMAIL, Ayman; 313 Car- dinal Medeiros, Apt 3, Cambridge, Massachusetts 02141 (US). (74) Agent: KIM, Ji-Eun et al.; Sterne, Kessler, Goldstein & Fox P.L.L.C., 1100 New York Avenue, NW, Washington, District of Columbia 20005 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, — (54) Title: FACTOR IX FUSION PROTEINS AND METHODS OF MAKING AND USING SAME Figure 2 1-1 © (57) : The present disclosure provides Factor IX (FIX) fusion proteins comprising at least one heterologous moiety, such as C an XTEN. The present disclosure further discloses methods of making and using the FIX fusion proteins. [Continued on next page] WO 2018/144623 Al MIDEDIMOMOIDEIREEMOMMHOEHRIMMOVOIS UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a))