baber/WOPTO huggingface dataset:
Patent BR-PI0715660-B1 (BR)
Title: Anticorpo isolado que se liga a il-31 humana, e, uso de um anticorpo monoclonal
Inventor: ANTHONY W SIADAK
IPC: C07K16/24
Filed: 2007-09-04
Abstract: anticorpo monoclonal ou fragmento de anticorpo, métodos para reduzir, bloquear, inibir, ou neutralizar inflamação, prurite e arranhadura em um mamífero, e, anticorpo isolado. são obtidas novas composições derivadas de sítios de ligação em antígeno de imunoglobulinas tendo afinidade por il-3 1. as composições exibem propriedades de ligação imunológicas de moléculas de anticorpo capazes de ligação especificamente em uma il-3 1 de humano. são obtidas regiões cdr derivadas de mesmos ou diferentes grupos de imunoglobulinas. também são obtidos polipeptídeos de cadeia única nos quais os domínios vh e vl estão ligados. as moléculas sfv podem incluir grupos de polipeptideo ancilares que podem ser bioativos, ou que proporcionam um sítio de ligação para outros grupos úteis. as composições são úteis em ensaios de ligação específicos, esquemas de purificação por afinidade, seleção de toxina ou droga, imagem, e agentes terapêuticos imunológicos ou genéticos para doenças inflamatórias. a invenção deste modo proporciona polipeptideos novos, os dnas codificadores daqueles polipeptídeos, cassetes de expressão compreendendo aqueles dnas, e métodos de indução da produção dos polipeptídeos. a invenção adicionalmente proporciona as seqtiências de aminoácidos das regiões variáveis dos anticorpos monoclonais e o uso destes anticorpos monoclonais ou fragmentos de anticorpo juntamente com uma molécula igg4 fc de humano.
Patent BR-PI0716882-B1 (BR)
Inventor: CHARLES V BARLOW
IPC: G01R19/25
Filed: 2007-09-07
Abstract: An apparatus, method, and system for measuring the magnetic field produced by phase conductors in multi-phase power lines. The magnetic field measurements are used to determine the current load on the conductors. The magnetic fields are sensed by coils placed sufficiently proximate the lines to measure the voltage induced in the coils by the field without touching the lines. The x and y components of the magnetic fields are used to calculate the conductor sag, and then the sag data, along with the field strength data, can be used to calculate the current load on the line and the phase of the current. The sag calculations of this invention are independent of line voltage and line current measurements. The system applies a computerized fitter routine to measured and sampled voltages on the coils to accurately determine the values of parameters associated with the overhead phase conductors.
Patent BR-PI0801248-B1 (BR)
Title: Fonte estável de ultra-som para calibração de equipamentos de medição de ultra-som, método para emissão de um sinal de ultra-som utilizando uma fonte estável e sistema para calibração de equipamentos de medição de ultra-som
Inventor: ELYR TEIXEIRA DE ALMEIDA ALVES
IPC: G01N29/42
Filed: 2008-04-30
Abstract: fonte estável de ultra-som para calibração de equipamentos de medição de ultra-som, método para emissão de um sinal de ultra-som utilizando uma fonte estável e sistema para calibração de equipamentos de medição de ultra-som. a presente invenção refere-se a uma fonte estável de ultra-som (1) para calibração de equipamentos de medição de ultra-som e, mais especificamente a uma fonte estável de ultra-som (1) para uso como padrão de transferência de rastreabilidade na calibração de balanças de força de radiação. a fonte estável (1) da presente invenção compreende um microcontrolador (9) conectado a um meio de entrada de parâmetros de operação (5) da fonte e a um meio de geração de sinais (10, 17) para um transdutor (2). um amplificador de sinal com ganho programável (12) controlado pelo microcontrolador é proporcionado para alterar o ganho do sinal gerado pelo gerador de sinais (10, 17) antes de seu envio ao meio de saída (16). afonte estável (1) da presente invenção utiliza eletrônica dedicada, proporcionando amigavelmente ao usuário suas diversas opções de configuração, sendo previsto ainda um meio de conexão a um dispositivo remoto (14) que possibilita a automação remota da fonte (1). é também contemplado um método para calibração de equipamentos de medição de ultra-som utilizando a fonte estável da presente invenção.
Patent BR-PI0804139-B1 (BR)
Title: composição pesticida
Inventor: TSUDA NAOKI
IPC: A01N37/10
Filed: 2008-09-04
Abstract: composição pesticida. a presente invenção refere-se a uma composição pesticida que inclui uma microcápsula na qual um óleo que contém um ingrediente ativo pesticida e um solvente orgânico é coberto com uma parede feita de uma resina termorrígida; pelo menos um tipo selecionado no grupo que consiste em éster de ácido graxo com poliglicerina, éster de ácido graxo com sacarose e ácido alquil-benzenossulfônico ou seu sal; um espessante; e água. a composição pesticida tem um desempenho de eluição apropriado para uma situação aplicada, sem a necessidade de mudar o projeto da microcápsula em si. na qualidade da resina termorrígida, prefere-se uma resina de poliuretana ou uma resina de poíiuréia. na qualidade do ingrediente ativo pesticida, cita-se um ingrediente ativo regulador do crescimento de insetos, tal como 4-fenóxi-fenil-2-(2-piridilóxi)-propil-éter.
Patent BR-PI0903275-B1 (BR)
Title: Processo de extração e purificação de artemisinina a partir de massa sólida de artemisia annua utilizando dióxido de carbono
Inventor: MARIA ANGELA DE ALMEIDA MEIRELES
IPC: A61K36/282
Filed: 2009-04-02
Abstract: processo de extração e purificação de artemisinina a partir de massa sólida de artemisia annua utilizando dióxido de carbono descreve-se um processo de extração e purificação de artemisinina a partir de massa sólida de artemísia annua utilizando dióxido de carbono supercrítico compreendendo pelo menos (i) uma primeira etapa de extração que consiste em um contato e dissolução da massa sólida particulada por co2 supercrítico em um extrator (e1) obtendo co2 e droga vegetal dissolvida; (ii) uma segunda etapa de purificação que consiste em um contato entre co2 e extrato vegetal dissolvido com uma fase fixa polar em uma coluna fracionadora (fi); e (iii) uma terceira etapa de eluição que consiste em um contato entre mistura de co2 e co-solvente com fase fixa polar na coluna fracionadora (f1); (iv) o extrator (e1) e a coluna fracionadora (f1) sendo dispostos em linha em um mesmo circuito. é descrito, ainda, uma composição farmacêutica compreendendo contendo como princípio ativo artemisina a partir desto processo ora descrito nesta invenção; e b) um veículo fisiologicamente aceitável, para tratamento da malária.
Patent BR-PI0922187-B1 (BR)
Title: Métodos para gerar um polinucleotídeo e para gerar uma célula hospedeira
Inventor: Darren m platt
IPC: C12N15/06
Filed: 2009-11-19
Abstract: composição, vetor, kit para a montagem de um polinucleotídeo, biblioteca de moléculas de ácido nucleico, métodos para gerar um polinucleotídeo, e uma célula hospedeira, célula hospedeira, polinucleotídeo, e, método para fabricar um vetor. a presente invenção fornece composições e métodos para a montagem rápida de um ou mais polinucleotídeos montados a partir de uma pluralidade de polinucleotídeos componentes. os métodos da invenção utilizam vetores de ácido nucléico circular que compreendem um segmento de dna d flanqueado por uma sequência ligadora recozível, pares de sequência de ligador recozíveis la e lb ou sequência de ligador recozível / pares de segmento de ligação de iniciador la e pc ou pa e lb. a digestão de endonuclease de restrição de uma pluralidade de vetores contendo os segmentos de dna ao montado gera uma pluralidade de fragmentos de dna que compreendem os elementos pa-d-lb, la-d-lb e la-dpb ou d-lb, la-d-lb e la-d. as sequências de sequências de ligador recozível la e lb fornecem terminais complementares aos fragmentos de dna, que são utilizados na recombinação homóloga mediada por célula hospedeira ou junto com os segmentos de ligação de promotor pa e pb em uma reação de montagem de ciclo de polimerase para a montagem ordenada dos vários segmentos de dna em um ou mais polinucleotídeos montados.
Patent BR-PI1016059-B1 (BR)
Title: Contador eletrônico, dispositivo de selagem ultrassônica, e, máquina de produção de embalagem
Inventor: ANGELO BONI
IPC: B65B57/00
Filed: 2010-05-26
Abstract: “contador eletrônico, dispositivo de selagem ultrassônica, e, máquina de produção de embalagem” máquina de produção de embalagem (1) que pode ser operada para produzir embalagens seladas (8) feitas de material de produção de embalagem em folha termosselado (3) e contendo um produto alimentício, e compreendendo um dispositivo de selagem ultrassônica (12) que inclui uma fonte de sinal de energia elétrica (19), que pode ser operada para gerar um sinal de energia elétrica (vus); um transdutor ultrassônico (2), eletricamente acoplado com a fonte do sinal da energia elétrica (19), para receber um sinal de energia elétrica (vus) e, responsivamente, termosselar a material de produção de embalagem em folha (3); e, um contador eletrônico (10) que pode ser operado para contar os ciclos de selagem ultrassônica do dispositivo de selagem ultrassônica (12).
Patent EA-000785-B1 (EA)
Title: A method for large scale isolation and purification of plasmid dna
Inventor: LEE ANN L
IPC: C12N1/06
Filed: 1996-05-15
Abstract: 1. A process for large scale isolation and purification of plasmid DNA from large scale microbial cell fermentations, comprising: a) harvesting microbial cells from a large scale fermentation; b) adding to the harvested microbial cells a sufficient amount of a lysis solution; optionally not comprising lysozyme; c) heating the microbial cells of step b) to a temperature between 70 degree C and 100 degree C in a flow-through heat exchanger to form a crude lysate; d) centrifuging the crude lysate and collecting supernatant e) filtering and diafiltering the supernatant of step d) providing a filtrate; f) contacting the filtrate of step e) with an anion exchange matrix; g) eluting and collecting plasmid DNA from the anion exchange matrix; h) contacting the plasmid DNA from step g) with a reversed phase high performance liquid chromatography matrix; and i) eluting and collecting the plasmid DNA of step g) from the matrix. 2. The process of claim 1 wherein optionally concentrating and/or diafiltering the product of step i) into a pharmaceutically acceptable carrier. 3. The process of claim 2 wherein optionally sterilizing the DNA product. 4. The process of claims 1-3 wherein the heating of step c) is to a temperature between 70 degree C and 77 degree C. 5. The process of claims 1-3 wherein the lysis solution of step b) contains a sub-microgram concentration of lysozyme. 6. The process of claims 1-3 optionally including RNAsa treatment at any step following step a). 7. The process of claims 1-3 wherein the lysis solution of step b) is modified STET buffer. 8. The process of claims 1-3 wherein the lysis solution of step b) is modified STET buffer containing a sub-microgram concentration of lysozyme.
Patent EA-000665-B1 (EA)
Title: Catalyst activation and rejuvenation process
Inventor: HOEK AREND
IPC: B01J37/18
Filed: 1996-11-06
Abstract: 1. A process for the activation or rejuvenation of a catalyst in the presence of a hydrocarbon liquid, which catalyst comprises a Group Ib, VIIb or VIII metal compound, by contacting the catalyst with a hydrogen-containing gas at a hydrogen partial pressure of at least 15 bar abs. 2. A process as claimed in claim 1, wherein the hydrogen partial pressure is at least 20 bar abs. 3. A process as claimed in claim 2, wherein the hydrogen partial pressure is at least 30 bar abs and at most 200 bar abs. 4. A process as claimed in any one of the preceding claims, wherein the catalyst comprises a cobalt compound and a carrier selected from alumina, silica, titania, zirconia or mixtures thereof. 5. A process as claimed in any one of the preceding claims, wherein the temperature is kept in the range from 180 to 400  degree C. 6. A process as claimed in any one of the preceding claims, wherein the superficial gas velocity of the hydrogen-containing gas is from 0.5 to 30 cm/sec and the hydrogen-containing gas is employed comprising from 25 to 100% by volume of hydrogen. 7. A process as claimed in any one of the preceding claims, wherein the catalyst is contacted with the hydrogen or hydrogen-containing gas for 0.5 to 48 hours. 8. A hydrocarbon synthesis process which comprises activating a hydrocarbon synthesis catalyst in the presence of a hydrocarbon liquid by contacting the catalyst with a hydrogen-containing gas at a hydrogen partial pressure of at least 15 bar abs, and, subsequently, contacting the catalyst with a mixture of hydrogen and carbon monoxide at hydrocarbon synthesis reaction conditions. 9. A process as claimed in claim 9, wherein the hydrocarbon liquid, which comprises the product of the hydrocarbon synthesis step, is led from the hydrocarbon synthesis step to the rejuvenation step, in which step the hydrocarbon liquid is hydrogenated and hydrogenated product is obtained.
Patent EA-004255-B1 (EA)
Title: The use of [(2,4,6-triisopropyl-phenyl)-acetyl]-sulfamic acid 2,6-diisopropyl-phenyl ester as sebaceous gland secretion inhibitor, in particular, for the treating of acne and compositions and methods based on the compound thereof
Inventor: HOMAN REYNOLD
IPC: A61P17/00
Filed: 2001-01-23
Abstract: 1. A pharmaceutical composition comprising an acne-inhibiting amount of a compound named [(2,4,6-triisopropyl-phenyl)-acetyl]-sulfamic acid 2,6-diisopropyl-phenyl ester and a pharmaceutically acceptable carrier. 2. The use of a compound named [(2,4,6-triisopropyl-phenyl)-acetyl]sulfamic acid 2,6-diisopropyl-phenyl ester for the manufacture of a medicament for the treatment of acnes. 3. A pharmaceutical composition comprising a sebaceous gland secretion-inhibiting amount of a compound named [(2,4,6-triisopropyl-phenyl)acetyl]-sulfamic acid 2,6-diisopropyl-phenyl ester and a pharmaceutically acceptable carrier. 4. The use of a compound named [(2,4,6-triisopropyl-phenyl)-acetyl]sulfamic acid 2,6-diisopropyl-phenyl ester for the manufacture of a medicament for the treatment of diseases caused by sebaceous gland disorders. 5. The use of a compound according to Claim 4 wherein said disorder is perioral dermatitis. 6. The use of a compound according to Claim 4 wherein said disorder is rosacea. 7. The use of a compound according to Claim 4 wherein said disorder is corticosteroid induced acneform lesions. 8. The use of a compound according to Claim 4 for the treatment of fatty skin. 9. A method of inhibiting AFAT comprising administering to a patient in need of said treatment an AFAT inhibiting amount of a compound named [(2,4,6-triisopropyl-phenyl)-acetyl]-sulfamic acid 2,6-diisopropyl-phenyl ester or a pharmaceutically acceptable salt thereof. 10. A method of inhibiting ACAT and AFAT comprising administering to a patient in need of said treatment an ACAT and AFAT inhibiting amount of a compound named [(2,4,6-triisopropyl-phenyl)-acetyl]-sulfamic acid 2,6-diisopropyl-phenyl ester.
Patent EA-009600-B1 (EA)
Title: Process for preparing caprolactam by admixture of cyclohexanone oxime to a reaction mixture under turbulent flow conditions
Inventor: SMEETS THEODORUS MARIA
IPC: B01F5/04
Filed: 2004-05-17
Abstract: The invention relates to a process for preparing caprolactam by admixture of cyclohexanone oxime to a reaction mixture comprising caprolactam and sulfuric acid using a mixing device, said mixing device comprising (i) a tube through which the reaction mixture can flow, and (ii) channels disposed around the tube, said channels opening into the tube, said process comprising: passing the reaction mixture through the tube, and feeding the cyclohexanone oxime into the reaction mixture through one or more of said channels, wherein Re > 5000, Re being the Reynolds number as defined by ρV.D/η, wherein ρ = density (in kg/m) of the reaction mixture that is fed to the tube, V = velocity of the reaction mixture, V being defined as W/A, wherein W is the flow rate (in m/s) of the reaction mixture that is fed into the tube and A is the cross section area of the tube (in m) at the level where said channels open into the tube, D = diameter of the tube at the level where said channels open into the tube (in m), η = viscosity of the reaction mixture that is fed into the tube (in Pa.s).
Patent EA-008163-B1 (EA)
Title: Method for removing air wave effect from offshore frequency domain controlled-source electromagnetic data
Inventor: LU XINYOU
IPC: G01V3/12
Filed: 2004-02-20
Abstract: A method for removing the air wave effect from offshore frequency domain controlled source electromagnetic survey data. The region of interest is modeled with (111) and without (113) a top air layer. The electromagnetic field due to the source is computed at the survey receiver positions for each source position for both models. The difference between the fields computed (116) from the two models is the air wave effect, which is then subtracted (117) from the field data for the corresponding source-receiver geometry.
Patent EA-010859-B1 (EA)
Title: Pyrimidyne and pyridazine heteroarylamines-derivatives as glycogen synthase-kinase 3-beta inhibitors (gsk3 inhibitors)
Inventor: FREYNE EDDY JEAN EDGARD
IPC: C07D403/04
Filed: 2002-10-29
Abstract: This invention concerns a compound of formula (I),a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein ring A is a 6-membered heterocycle; pyrimidinyl or pyridazinyl derivatives; Ris hydrogen; aryl; formyl; Calkylcarbonyl; optionally substituted Calkyl; Calkyloxycarbonyl; optionally substituted Calkyloxy Calkylcarbonyl; X is a direct bond or a linker atom or group; Z is a direct bond or a linker atom or group; Ris hydrogen, Calkyl, Calkenyl, Calkynyl, a carbocycle or a heterocycle, each of said groups may optionally be substituted; Ris hydrogen; hydroxy; halo; optionally substituted Calkyl or Calkenyl or Calkynyl; Calkyloxy; Calkylthio; Calkyloxycarbonyl; Calkylcarbonyloxy; carboxyl; cyano; nitro; amino; mono- or di(Calkyl)amino; polyhalo Calkyl; polyhalo Calkyloxy; polyhalo Calkylthio; R; R- Calkyl; R-O-; R-S-; R-C(=O)-; R-S(=O)-; R-S =O R-S(=O)-NH-; R-S(=O)-NH-; R-C(=O)-; -NHC(=O)H; -C(=O)NHNH; R-C(=O)-NH-; R-C(=O)-NH-; -C(=NH)R; -C(=NH)R; Ris an optionally substituted heterocycle provided that -X-Rand/or Ris other than hydrogen; their use, pharmaceutical compositions comprising them and processes for their preparation.
Patent EA-009253-B1 (EA)
Title: Elevator arrangement
Inventor: YLINEN JARI
IPC: B66B1/46
Filed: 2005-01-25
Abstract: A method for allocating an elevator in a destination floor elevator system comprising an elevator group consisting of several elevators, a passenger data terminal for reserving elevators for use by passengers, an elevator group control system for controlling the elevators in response to signals from the passenger data terminal. The method of the invention comprises the following steps: the size and destination floor of the group of passengers are input into the control system of the elevator group, one or more elevators are allocated to the group of passengers by utilizing the size and destination floor of the group, and the members of the group of passengers are informed about the allocation.
Patent EA-010364-B1 (EA)
Title: Process for the manufacture of 1.2-dichloroethane
Inventor: STREBELLE MICHEL
IPC: C08F14/06
Filed: 2005-12-21
Abstract: Process for the manufacture of 1,2-dichloroethane starting with a hydrocarbon source according to which: a) the hydrocarbon source is subjected to cracking which produces a mixture of products containing ethylene and other constituents; b) the said mixture of products is separated into a fraction enriched with compounds which are lighter than ethylene, containing part of the ethylene (fraction A), into a fraction enriched with ethylene (fraction B) and into a heavy fraction (fraction C); c) fraction A is conveyed to a chlorination reactor and fraction B to an oxychlorination reactor, in which reactors most of the ethylene present in fractions A and B is converted to 1,2-dichloroethane; d) the 1,2-dichloroethane obtained is separated from the streams of products derived from the chlorination and oxychlorination reactors.
Patent EA-011785-B1 (EA)
Title: Method for controlling authenticity of alcohol products and transportation thereof (variants) and a system for carrying out method
Inventor: SKOBELEV MIKHAIL MIKHAILOVICH
IPC: G06F17/40
Filed: 2005-12-12
Abstract: The invention relates to electronic information systems. The inventive method for controlling authenticity of alcohol products and the transportation thereof consists in assigning an identification code to each product item, in introducing said code into a producer server database, in controlling the authenticity of the product during the transportation thereof by comparing the product unit identification code with the code stored in said identification code database and, when said codes coincide, in delivering a message proving the authenticity of said product unit. The inventive method is characterised in that the identification code carrier for each product unit is embodied in the form a radiofrequency label in the form of a transponder, which is provided within incorporated antenna and a microchip containing the identification codes of each product unit recorded therein, is built into a label, or under a plug or cap during production or is fixed to each imported product unit, wherein said identification codes are transmitted to the database of a taxing authority server, when said product is moved within a warehouse or at a point of sale, the identification codes are read out from the radiofrequency labels and the thus obtainable data items are introduced into the warehouse or the point of sale server database and into the database of a taxing authority server. When the products are moved from the warehouse or sold at the point of sale, the inventive method consists in reading out the identification codes from the radiofrequency label of the moved or sold products and in introducing the thus obtained data items about the product moving and selling into the warehouse or the point of sale server database and simultaneously into the taxing authority server database.
Patent EA-016092-B1 (EA)
Title: Method for determining the location of at least two impacts
Inventor: DUHEILLE REMI
IPC: G06F3/043
Filed: 2008-12-19
Abstract: The invention relates to a method for determining the locations of at least two impacts Fand Fon a surface using one or more sensors S, i = 1 to n, with n being the number of sensors, said impacts Fand Fgenerating a signal being sensed by the one or more sensors, wherein each sensor provides a sensed signal s(t), i = 1 to n, with n being the number of sensors. To be able to determine simultaneous impacts of different amplitudes the method comprises the steps of: identifying the location x of one impact, and determining a modified sensed signal s' (t) for each sensor in which the contribution due to the identified impact is reduced and which is based on a comparison, in particular a correlation, of each of the sensed signals s(t) and a predetermined reference signal r(t) corresponding to a reference impact Rat location j. The invention also relates to methods based on couples of sensed signals and to a device carrying out the inventive methods.
Patent EA-015785-B1 (EA)
Title: Process for the removal of carbon dioxide from gas streams
Inventor: MAUNDER ANTHONY DWIGHT
IPC: C10L3/10
Filed: 2008-05-16
Abstract: A process for the removal and recovery of carbon dioxide from a gaseous stream, in particular the removal and recovery of carbon dioxide, and optionally hydrogen sulphide, from a natural and/or synthesis gas stream. Furthermore, the present invention provides for the release of the removed and recovered carbon dioxide, and optionally hydrogen sulphide, at an elevated pressure, thereby reducing the high carbon dioxide compression costs associated with further chemical processing e.g. for underground carbon sequestration and/or for subsurface enhanced hydrocarbon recovery and/or for the manufacture of urea.