Patent CA-3086832-A1 (CA)
Inventor: GUNN HAROLD DAVID
IPC: A61P35/00
Filed: 2018-12-28
Abstract: CA 03086832 2020-06-24 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1 11111 1111111 11 111111 111 11111 11111111 1 1 111 1111 1111 1111 11111 1111 111 11111111111 111 1111 Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2019/134036 Al 11 July 2019 (11.07.2019) WIPO I PCT (51) International Patent Classification: (74) Agent: KINGWELL, Brian et al.; 550 Burrard Street, A 61K 39/00 (2006.01) A61P 37/04 (2006.01) Suite 2300, Bentall 5, Vancouver, British Columbia V6C A 61K 9/00 (2006.01) C12N 5/078 (2010.01) 2B5 (CA). A 61P 35/00 (2006.01) C12N 5/10 (2006.01) (81) Designated States (unless otherwise indicated, for every (21) International Application Number: kind of national protection available): AE, AG, AL, AM, PCT/CA2018/051683 AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (22) International Filing Date: DZ, EC, EE, EG, ES, F1, GB, GD, GE, GH, GM, GT, HN, 28 December 2018 (28.12.2018) HR, HU, ED, EL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (25) Filing Language: English KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (26) Publication Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (30) Priority Data: SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, 62/613,259 03 January 2018 (03.01.2018) US TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 62/743,935 10 October 2018 (10.10.2018) US (84) Designated States (unless otherwise indicated, for every (71) Applicant: QU BIOLOGICS INC. [CA/CA]; 44'75 Way- kind of regional protection available): ARIPO (BW, GH, burne Drive, Suite 305, Burnaby, British Columbia V5G GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, 4X4 (CA). UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (72) Inventors: GUNN, Harold David; 1116 Ironwork Pas- EE, ES, FI, FR, GB, GR, HR, HU, EE, IS, IT, LT, LU, LV, sage, Vancouver, British Columbia V6H 3P1 (CA). MUL- MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, LINS, David W.; 23 Douglas Ridge, Norwich, Vermont TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, 05055 (US). BAZETT, Mark; c/o 44'75 Wayburne Dri- KM, ML, MR, NE, SN, TD, TG). ve, Suite 305, Burnaby, British Columbia V5G 4X4 (CA). KALYAN, Shirin; c/o 44'75 Wayburne Drive, Suite 305, Burnaby, British Columbia V5G 4X4 (CA). (54) Title: INNATE TARGETING OF ADOPTIVE CELLULAR THERAPEES TO) MON 2), 80000 1¨ 60000 (a 40000 s- -s-.5. 20000 . 1-1 4t 64, \e, ,c), \e ,0 = s9 stz *>) ." 631 ep 04Z? (-2p nep +0 71. Figure 2 Anfi-CXC R3 re) 1-1 (57) Abstract: Therapeutic modalities are provided for targeting adoptive cellular therapies to specific sites of disease, involving the use of specific repertoirs of PRR ligands. In effect, innate immune system signaling is provoked so as to facilitate the homing of adoptive 0 immune cells to sites of disease, for example to the site of a solid tumor. [Continued on next page] CA 03086832 2020-06-24 WO 2019/134036 Al I11111 NMI II lIllIl 11111 11111 011MI I II 111 11111 11111 llH 11111 0ll lH 11111111111 0l 1111 Published: ¨ with international search report (Art. 21(3)) ¨ in black and white; the international application as filed contained color or greyscale and is available for download from PATENTSCOPE