baber/WOPTO huggingface dataset:
Patent CA-3133989-A1 (CA)
Inventor: ALPERT AMIR
IPC: C12N5/10
Filed: 2020-03-19
Abstract: A method for producing T cells with improved efficacy for adoptive immunotherapy includes obtaining a population of CD8+ T cells from a patient or a donor, determining a % of CD28+ CD8+ T cells in the obtained population, activating the determined population with anti-CD3 antibody and anti-CD28 antibody, provided that the determined population comprises at least 50% of CD28+ CD8+ T cells, or activating the determined population with anti~CD3 antibody in the absence of anti-CD28 antibody, provided that the determined population comprises less than 50% of CD28+ CD8+ T cells, transducing the activated population with a viral vector, and expanding the transduced population, in which the transducing and the expanding are carried out in the presence of at least one cytokine.
Patent CA-3135377-A1 (CA)
Inventor: GRAS PENA RAFAEL
IPC: C12Q1/02
Filed: 2020-03-31
Abstract: The current disclosure provides for methods of promoting differentiation of pluripotent stem cells into thymic epithelial cells or thymic epithelial cell progenitors as well as the cells obtained from the methods, and solutions, compositions, and pharmaceutical compositions comprising such cells. The current disclosure also provides for methods of using the thymic epithelial cells or thymic epithelial cell progenitors for treatment and prevention of disease, generating organs, as well as other uses, and kits.
Patent CA-3136625-A1 (CA)
Title: Anticorps a action depletive sur le recepteur klrg1 (killer cell lectin-like receptor subfamily g member 1)
Inventor: GULLA STEFANO VICENZO
IPC: A61K39/395
Filed: 2020-04-09
Abstract: Le récepteur KLRG1 (killer cell lectin-like receptor G1) s'exprime sur les lymphocytes T et NK et se lie à des ligands sur les cellules épithéliales et mésenchymateuses. Le ligand pour le récepteur KLRG1 a été décrit comme étant la E-cadhérine, la N-cadhérine et la R-cadhérine. La présente invention concerne et résulte de la découverte et de la caractérisation d'anticorps qui se lient au domaine extracellulaire du récepteur KLRG1, mais n'interfèrent pas avec son interaction avec les ligands que sont l'E-cadhérine, la N-cadhérine et la R-cadhérine. Les anticorps décrits ont été obtenus par la technologie des hybridomes de souris et peuvent être humanisés par greffage de leurs régions déterminant la complémentarité (CDR) dans une structure humaine. Les anticorps décrits peuvent être utilisés en tant qu'agents thérapeutiques efficaces. L'invention concerne divers anticorps, ou les fragments de liaison à l'antigène de tels anticorps, ainsi que divers procédés thérapeutiques et/ou diagnostiques, entre autres caractéristiques.
Patent CA-3141817-A1 (CA)
Inventor: KAMPF JAMES PATRICK
IPC: G01N33/53
Filed: 2020-05-22
Abstract: La présente invention concerne des méthodes et des compositions permettant de suivre, diagnostiquer, pronostiquer et déterminer des schémas thérapeutiques chez des sujets atteints ou soupçonnés d'être atteints d'une lésion rénale. En particulier, l'invention concerne des méthodes, des compositions et des kits pour détecter une chimiokine 14 à motif C-C en combinaison avec la créatinine, le débit urinaire et/ou la cystatine C pour prédire la probabilité d'une lésion rénale aiguë persistante, ainsi que des méthodes pour traiter de manière appropriée un sujet sur la base de la probabilité qui lui a été attribuée.
Patent CA-3141977-A1 (CA)
Inventor: TIGGES MARTIN
IPC: B60C23/00
Filed: 2021-12-13
Abstract: A rotary transmission leadthrough of a pressure control system for a tire having a hub on an axle, a stator unit mounted thereon so its position is axially adjustable relative thereto. The stator unit has an end member and a bearing member extending therefrom with a bearing surface on its outer radial surface, the end member projecting outwards from the bearing surface. The bearing member retains an inner bearing shell of a rolling bearing carrying the hub. A connector is mounted on the end member to an air supply, and an air conduit connecting the connector with an air passage extending under the bearing surface. An opening in the bearing surface connects to the air passage with an air chamber. A rotor unit connects to the hub by torque fit, and is arranged radially outside to the stator unit bearing member and has a connector connected to the tire valve.
Patent CA-3142051-A1 (CA)
Title: System and method for limiting mobile phone use by drivers
Inventor: MEHTA DILIP JEHTALA
IPC: H04W48/04
Filed: 2020-05-29
Abstract: A system for limiting use of an electronic mobile device by a driver of a vehicle is provided. The system includes a mobile device controller for removable connection with a vehicle and an electronic mobile device for wireless communicating with the mobile device controller. The electronic mobile device includes an application installed thereon and an electronic mobile device processor programmed to execute one or more instructions of the application stored in the electronic mobile device. The instructions include temporarily disabling radio frequency signal transmission of the electronic mobile device, requesting an input via the one or more electronic mobile devices that satisfies a predetermined criterion, receiving the input that satisfies the predetermined criterion from at least one of the one or more electronic mobile devices, and restoring radio frequency signal transmission of the at least one of the one or more electronic mobile devices.
Patent CA-3146408-A1 (CA)
Title: Procede de fabrication d'un lit adsorbant composite a haute densite, adsorbeur comprenant celui-ci, et separation de gaz basee sur l'adsorption utilisant l'adsorbant
Inventor: COIGNET PHILIPPE A
IPC: B01J20/30
Filed: 2020-07-11
Abstract: L'invention concerne un lit adsorbant, comprenant au moins une structure composite élémentaire qui comprend des particules adsorbantes dans une matrice polymère, le lit adsorbant ayant un garnissage de lit, ? bed, défini comme un volume occupé par ladite au moins une structure composite élémentaire V ecs divisé par un volume du lit adsorbant V bed où ? bed est supérieur à 0,60.
Patent CA-3147926-A1 (CA)
Inventor: DOUGLASS ANDREW F
IPC: G01F23/22
Filed: 2022-02-04
Abstract: A system includes a fuel level sensing probe inside a fuel tank and an exciter wire bundle to connect the fuel level sensing probe to a power source outside the tank. The exciter wire bundle includes an excitation wire and a grounded guard wire. The excitation wire and the grounded guard wire each include a resistive non-metallic wire. The system also includes a return signal wire bundle to connect the fuel level sensing probe to a device configured to measure a quantity of fuel within the tank. The return signal wire bundle includes a return signal wire and a grounded guard wire. The grounded guard wire of the return signal wire bundle and the grounded guard wire of the exciter wire bundle are configured to shield the return signal wire from electromagnetic interference. The return signal wire and the grounded guard wire each include a resistive non-metallic wire.
Patent CA-3149268-A1 (CA)
Title: Inverted closed bellows with lubricated guide ring support
Inventor: HOLLOHAN CODY
IPC: E21B43/12
Filed: 2020-09-09
Abstract: A pumping system deployed in a wellbore has a motor, a pump driven by the motor, and a volumetric compensator connected to the motor to accommodate the expansion and contraction of fluids contained within the motor. The volumetric compensator has a head connected to the motor, a base that includes a fluid exchange port that extends to the wellbore, and a housing extending between the head and the base. The volumetric compensator further includes an inverted bellows assembly contained within the housing. The inverted bellows assembly includes a metal bellows that has an interior, an exterior, a proximal end and a distal end. The interior of the metal bellows is in fluid communication with the wellbore.
Patent CA-3150289-A1 (CA)
Title: Manifolds for providing hydraulic fluid to a subsea blowout preventer and related methods
Inventor: BABBITT GUY ROBERT
IPC: E21B34/04
Filed: 2014-09-27
Abstract: This disclosure includes manifolds, subsea valve modules, and related methods. Some manifolds and/or subsea valve modules include one or more inlets, each configured to receive hydraulic fluid from a fluid source, one or more outlets, each in selective fluid communication with at least one of the inlets, and one or more subsea valve assemblies, each configured to selectively control hydraulic fluid communication from at least one of the inlets to at least one of the outlets, where at least one of the outlets is configured to be in fluid communication with an actuation port of the hydraulically actuated device.
Patent CA-3152076-A1 (CA)
Inventor: HENKEL GUNTER
IPC: G10H1/32
Filed: 2021-03-30
Abstract: The object of the present invention is to provide an instrument and device rack for holding or storing electronic musical instruments and/or accessory equipment, which can be expanded in a simple and modular manner as required, and also to provide universal and orderly holding and arrangement of the musical instruments and/or accessory equipment or other accessories.1. The modular instrument and device rack (1) for holding or storing electronic musical instruments and/or accessory devices, wherein two telescopically height-adjustable T-shaped foot elements (2) are connected via a connecting bridge (3) and at least two bearing elements (4) for a storage plate (5) are detachably fastened to the connecting bridge (3), wherein at least one extension element (7) can be detachably arranged on each at least of two bearing elements (4) via a respective support element (6) at least at one height and inclination deviating from the bearing elements (4), wherein in the case of two or more extension elements (7) to be arranged one above the other, the respective extension elements (7) are arranged respectively with a common support element (6) on the respective bearing element (4).
Patent CA-3152508-A1 (CA)
Inventor: MULVIHILL MARK J
IPC: A61K31/519
Filed: 2020-08-28
Abstract: L'invention concerne des composés de formule (I), des compositions et des procédés utiles pour inhiber PERK et pour traiter des maladies et des troubles apparentés.
Patent CA-3153389-A1 (CA)
Inventor: AMARLOO HADI
IPC: G01N21/03
Filed: 2020-02-04
Abstract: In a general aspect, a vapor cell is presented that includes a dielectric body. The dielectric body includes a surface that defines an opening to a cavity in the dielectric body and a plurality of holes between the cavity and a side of the dielectric body. The vapor cell also includes a vapor or a source of the vapor in the cavity of the dielectric body. An optical window covers the opening of the cavity and has a surface bonded to the surface of the dielectric body to form a seal around the opening. Methods of manufacturing vapor cells are also presented.
Patent CA-3154528-A1 (CA)
Inventor: Cirik Ali Cagatay
IPC: H04W52/24
Filed: 2022-03-30
Abstract: Beam management and control resource set (CORESET) monitoring may be used in wireless communications. Multiple CORESETs associated with different TCI states may overlap in time. A  first CORESET, of the multiple CORESETs, may be activated with a plurality of TCI states and may be selected for monitoring. Other CORESETs, of the multiple CORESETs, having the same TCI states or at least one of the TCI states of the first CORESET may also be monitored.
Patent CA-3155075-A1 (CA)
Inventor: MITCHELL MICHAEL
IPC: A61K31/047
Filed: 2020-10-19
Abstract: La présente invention concerne des nanoparticules lipidiques (NPL) ou des compositions de celles-ci pour l'administration de molécules d'ARNm codant pour CAR, d'une molécule d'acide nucléique et/ou d'agents thérapeutiques à des cibles sélectionnées, telles que des cellules. Ainsi, dans divers aspects, la présente invention concerne également des procédés de prévention ou de traitement de maladies ou de troubles chez un sujet en ayant besoin à l'aide desdites NPL ou de compositions de celles-ci.
Patent CA-3155618-A1 (CA)
Title: Traitement d'affections epileptiques avec des modulateurs du recepteur gabaa
Inventor: HUBBS JED
IPC: A61P25/08
Filed: 2020-10-23
Abstract: Des modulateurs du récepteur GABAA et des compositions comprenant des modulateurs du récepteur GABAA pour le traitement d'affections épileptiques, sont divulgués. Sont également divulguées des méthodes de traitement d'affections épileptiques chez un sujet, par l'administration de modulateurs du récepteur GABAA ou d'une composition selon l'invention.
Patent CA-3157714-A1 (CA)
Title: Secure tokens for controlling access to a resource in a resource distribution network
Inventor: DESHMUKH PUSHPESH KUMAR
IPC: H04M15/02
Filed: 2020-10-14
Abstract: A system for generating and applying a secure token in a resource distribution network is provided. For example, a headend system generates a time-based token based on a time duration specified for a meter. The time-based token indicates the time duration for the meter. The time-based token is further generated based on an identifier of the meter. The headend system transmits the time-based token to the meter via at least a mesh network. After receiving the time-based token, the meter validates the time-based token to determine that the time-based token is generated for the meter based on information related to the identifier of the meter. If the meter determines that the time-based token is valid, the meter connects premises associated with the meter to a resource distribution network for at least the time duration specified in the time-based token.
Patent CA-3157908-A1 (CA)
Inventor: CHEIKH STEPHANE
IPC: G01W1/08
Filed: 2020-12-23
Abstract: L'invention concerne un drone météorologique (100) comprenant : un premier capteur (101) configuré pour mesurer de manière répétée un ou plusieurs paramètres indicatifs de la météo ; une mémoire (103) couplée au premier capteur (101) et configurée pour stocker des données enregistrées par le premier capteur (101), les données comprenant une série de paramètres mesurés de façon répétée ; et un processeur (104) couplé au premier capteur (104) et à la mémoire (103). Le processeur (104) est configuré pour analyser les données lorsqu'elles sont enregistrées par le premier capteur (101), et déterminer si les données dépassent une première valeur seuil et/ou se situent en dessous d'une seconde valeur seuil. Si le processeur (104) détermine que les données dépassent la première valeur de seuil et/ou se situent en dessous de la seconde valeur de seuil à au moins une occasion, le processeur (104) est configuré pour empêcher le stockage d'autres données provenant du premier capteur (101) dans la mémoire (102).
Patent CA-3158471-A1 (CA)
Inventor: ZHAO TIAN
IPC: G01N33/50
Filed: 2020-11-17
Abstract: Described herein are formulations, methods, and pH responsive compositions useful for the detection of primary and metastatic tumor tissues.
Patent CA-3159319-A1 (CA)
Title: Anticorps dirige contre c-kit et utilisation correspondante
Inventor: PARK SANG GYU
IPC: C07K16/28
Filed: 2020-11-24
Abstract: La présente invention concerne : un anticorps dirigé contre c-kit ou son fragment de liaison à l'antigène; un acide nucléique codant pour ce dernier; un vecteur comprenant l'acide nucléique; une cellule transformée au moyen du vecteur; un procédé de production de l'anticorps ou de son fragment de liaison à l'antigène; une composition pour prévenir ou traiter une maladie angiogénique le comprenant; et une méthode de prévention ou de traitement du cancer.
Patent CA-3159685-A1 (CA)
Inventor: WALTON BRADY
IPC: G06Q10/06
Filed: 2020-11-11
Abstract: Des procédés permettant d'assurer un partage d'informations pertinent pendant des incidents de sécurité publique consistent à surveiller des entrées associées à un incident, à déterminer qu'une entrée comprend des informations importantes ou critiques à communiquer à un agent de sécurité publique répondant, à accéder à des communications avec l'agent, à déterminer que l'entrée n'a pas été communiquée à l'agent, et à initier une action pour communiquer l'entrée à l'agent. L'entrée peut comprendre une entrée audio ou vidéo, ou une note composée par un répartiteur ou un preneur d'appel représentant des informations fournies par une personne portant l'incident ou obtenues par l'intermédiaire d'une interrogation de base de données. L'initiation de l'action visant à communiquer l'entrée à l'agent peut consister à fournir une indication à un répartiteur que l'entrée comprend des informations importantes ou critiques non encore communiquées à l'agent, à fournir des données au dispositif de communication monté sur le véhicule de l'agent, ou à fournir un avertissement audible ou un message audio au dispositif de communication portatif de l'agent.
Patent CA-3159874-A1 (CA)
Inventor: BELLO OLADAPO OLALEKAN
IPC: G02F1/13
Filed: 2020-11-25
Abstract: Various embodiments for configuring LC cells, LC panels, and methods of manufacturing LC panels are provided, comprising: various embodiments to increase the stiffness and/or rigidity of the LC cell, such that once it undergoes lamination processing to attach it to glass layers on either major surface of the LC cell, the LC cell will not undergo distortion/discontinuous cell gap when transformed into an LC panel.
Patent CA-3160880-A1 (CA)
Inventor: JONES CHRISTOPHER MARK
IPC: G06Q20/38
Filed: 2022-05-27
Abstract: The disclosed embodiments relate to computer-implemented systems and processes that generate and provision, in real time, directed digital content based on decomposed structured messaging data. For example, an apparatus may receive a plurality of messages that characterize first data exchanges initiated between a first counterparty and second counterparties during a first temporal interval. Each of the messages includes elements of message data associated with a real-time payment requested from the first counterparty by a corresponding one of the second counterparties. Based on the elements of message data, that apparatus may predict an occurrence of a second exchange of data that involves the first counterparty during a second temporal interval, and may transmit notification data that includes product data characterizing an available product associated with the predicted occurrence of the second data exchange to a device operable by the first counterparty for presentation within a digital interface.
Patent CA-3161154-A1 (CA)
Title: Treatment of hereditary angioedema with liver-specific gene therapy vectors
Inventor: COLOSI PETER
IPC: C12N15/864
Filed: 2020-11-13
Abstract: Provided herein are compositions and methods for treating a Cl esterase inhibitor deficiency by normalizing levels of the Cl esterase inhibitor protein in a subject having HAE.
Patent CA-3162490-A1 (CA)
Title: System and method for extracting liquid and solid hydrocarbons and their derivatives
Inventor: PODLIPSKIY VLADIMIR Y
IPC: C09K8/584
Filed: 2021-01-06
Abstract: A system and method for extracting liquid and solid hydrocarbons and their derivatives from natural and man-made hydrocarbon sources, including but not limited to oil sands, bitumen, asphalt, roofing shingles, and other hydrocarbon articles of manufacture. The hydrocarbon sources are prepared by dissolving, crushing and/or grinding. The prepared hydrocarbon sources are subjected to agitation where the solvent and hydrocarbon source as thoroughly mixed. The results of the agitation are then separated in one or both of a mesh screen shaker and a centrifuge. The mesh screen shaker subjects the materials to medium frequency oscillations. The centrifuge subjects the materials to high G-forces. The combined processes separate the hydrocarbons from solids and residual solids to less than 0.2% by weight.
Patent CA-3163555-A1 (CA)
Title: Forme galenique de methotrexate
Inventor: HOJGAARD BENT
IPC: A61K9/48
Filed: 2021-01-26
Abstract: La présente invention concerne une forme galénique comprenant un principe actif tel que le méthotrexate ou un sel pharmaceutiquement acceptable de celui-ci, en particulier sous forme de micro-billes, telles que des formes multi-particulaires, des mini-comprimés ou des granulés. L'invention concerne en outre des formes galéniques d'administration orale pour lesquelles la cinétique de saturation limite l'utilisation orale de doses plus élevées d'ingrédients actifs.
Patent CA-3165382-A1 (CA)
Title: Combinations
Inventor: SAMATAR AHMED ABDI
IPC: A61K31/55
Filed: 2020-12-16
Abstract: Disclosed herein are combinations of compounds for treating a disease or condition, such as cancer. A combination of compounds for treating a disease or condition can include a SERD inhibitor and another inhibitor (such as a CDK4/6 inhibitor, a selective aromatase inhibitor, a non-selective aromatase inhibitor, a mTOR inhibitor, a PI3K inhibitor, an ERK or a MEK inhibitor, AKT inhibitor, a BET inhibitor and an Aurora inhibitor), along with pharmaceutically acceptable salts of any of the foregoing.
Patent CA-3165906-A1 (CA)
Title: Method for dispersing live predatory mites of the phytoseiulus genus which are used in biocontrol
Inventor: MAIGNET PASCAL
IPC: A01N63/16
Filed: 2021-01-29
Abstract: The present invention relates to a sprayable aqueous composition for spreading biocontrol agents, comprising live biocontrol agents from the phytoseiidae family of the genus Phytoseiulus which are homogenously dispersed in a gel prepared from one or more thickening and/or gelling agents and an aqueous solution, the thickening and/or gelling agents being non-toxic for the biocontrol agents and the gel having a dynamic viscosity at zero velocity gradient of between 1 and 30,000 mPa.s.
Patent CA-3167308-A1 (CA)
Title: Compositions et methodes de regulation d'auto-immunite
Inventor: GETTS DANIEL
IPC: A61K48/00
Filed: 2021-01-08
Abstract: L'invention concerne des acides nucléiques recombinés codant pour des protéines de fusion (TFP) de récepteurs des lymphocytes T (TCR), des cellules immunes humaines modifiées exprimant les molécules codées, ainsi que des méthodes d'utilisation correspondantes destinées au traitement de maladies, notamment de maladies auto-immunes.
Patent CA-3168382-A1 (CA)
Inventor: KELLY CHARLES ROBERT
IPC: B42D15/04
Filed: 2022-07-20
Abstract: A greeting card with pop-up structure and a lock mechanism to maintain the greeting card and pop-up structure in an open or unfolded position without the use of locking tabs being used in conjunction with the pop-up structure.
Patent CA-3168416-A1 (CA)
Title: Aerosol generating device
Inventor: AN HWI KYEONG
IPC: A24F47/00
Filed: 2019-01-22
Abstract: Provided is an aerosol generating device including a case in which a heater for heating a cigarette is installed, a bracket for supporting components installed inside the case, a fastening member for fastening the case and the bracket, and a cap that is installed on an outer surface of the case in an inseparable manner to conceal the fastening member in the case.
Patent CA-3169484-A1 (CA)
Title: A method of producing a crystalline form of sodium 2-[(4s)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5-(trifluoromethyl)phenyl]-4h-quinazolin-4-yl]acetate trihydrat
Inventor: BUSCHMANN HELMUT
IPC: C07D239/84
Filed: 2021-03-01
Abstract: The present invention refers to an effective method of preparing a crystalline form of 2- [(4S)-8-fluoro-2-[4-(3-methoxyphenyl)piperazin-1-yl]-3-[2-methoxy-5- (trifluoromethyl)phenyl]-4H-quinazolin-4-yl]acetic acid sodium trihydrate.