baber/WOPTO huggingface dataset:
Patent SI-1653964-T1 (SI)
Title: Cancer combination therapy comprising azd2171 and zd1839
Inventor: WEDGE STEPHEN ROBERT
IPC: A61K41/00
Filed: 2004-07-08
Abstract: The present invention relates to a method for the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human which is optionally being treated with ionising radiation, particularly a method for the treatment of a cancer, particularly a cancer involving a solid tumour, which comprises the administration of AZD2171 in combination with ZD1839; to a pharmaceutical composition comprising AZD2171 and ZD1839; to a combination product comprising AZD2171 and ZD1839 for use in a method of treatment of a human or animal body by therapy; to a kit comprising AZD2171 and ZD1839; to the use of AZD2171 and ZD1839 in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human which is optionally being treated with ionising radiation.
Patent SI-1937274-T1 (SI)
Title: Use of estradiol valerate combined with dienogest for oral therapy of dysfunctional uterine bleeding in the form of oral contraceptives
Inventor: ZEUN SUSAN
IPC: A61K31/00
Filed: 2006-09-05
Abstract: The invention relates to the use of estradiol valerate combined with 17a- cyanomethyl-17-ß-hydroxyestra-4,9-diene-3on (dienogest) for producing a multi-phase combination preparation for the oral therapy of the dysfunctional uterine bleeding in the form of oral contraceptives. Said combination of estradiol valerate with dienogest comprises a first phase consisting of 2 daily dose units of estradiol valerate at 3 mg, a second phase consisting of 2 groups of daily dose units, whereby the first group contains 5 daily dose units of a combination of 2 mg estradiol valerate and 2 mg of dienogest and the second group contains 17 daily dose units consisting of a combination of 2 mg of estradiol valerate and 3 mg dienogest, a third phase consisting of 2 daily dose units having 1 mg estradiol valerate and an additional phase consisting of 2 daily dose units on a pharmaceutically harmless placebo. All of the daily dose units of the multi-phase combination and the pharmaceutically harmless placebo correspond to 28 days. The duration of application comprises at least one menstruation cycle and is dependent on individual wishes of the woman with respect to contraception.
Patent SI-2861579-T1 (SI)
Title: Benzamide derivatives for inhibiting the activity of abl1, abl2 and bcr-abl1
Inventor: DODD STEPHANIE KAY
IPC: C07D403/00
Filed: 2013-05-09
Abstract: The present invention relates to compounds of formula (I): in which Y, Y1, R1, R2, R3 and R4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.
Patent TR-200902344-T1 (TR)
Title: Anti-epidermal büyüme faktörü reseptör antikorları ile terapinin etkisinin geliştirilmesi için terapötik bileşimler.
Inventor: MOLINA LUIS ENRIQUE FERNANDEZ
IPC: A61K38/21
Filed: 2007-09-27
Abstract: Bu buluş, l IFN'lertıpı ile kombine şekilde Epidermal Büyüme Faktörü Reseptörüne (EGFR) karşı monoklonal antikorlar kullanılarak terapötık tedavinin sonuç verirlığını arttıran özgül terapötık bileşimleri açıklamaktadır.
Patent TR-200908301-T1 (TR)
Title: Bir fırın
Inventor: SERABATIR DAVUT AYHAN
IPC: F24C15/16
Filed: 2008-06-05
Abstract: Buluş konusu fırın (1), bir pişirme odası (2), pişirme odasının (2) dışında yer alan ve havayı hareketlendiren bir veya birden fazla sayıda fan, fan tarafından hareketlendirilen havanın pişirme odası (2) içine yönlendirilmesini sağlayan, pişirme odası (2) ile fanın bulunduğu hacmi ayıran bir arka duvar (3), arka duvar (3) üzerinde yer alan, fan tarafından hareketlendirilen havanın pişirme odasında (2) çevrimini sağlayan, fanın taradığı alana denk gelen kısımda, çeşitli sayı ve formda, çeşitli kombinasyonlarla arka duvarın (3) tercihan ortasında oluşturulmuş birden fazla sayıda emiş deliği (6) içermektedir.
Patent DE-3587325-T2 (DE)
Inventor: WOLFF MICHEL
IPC: A01D34/66
Filed: 1985-09-18
Granted: 1994-01-13
Abstract: The invention relates to rotary mowers driven from below. According to the invention, shafts (18) and wheels (23) have at least their operational dimensions approximately identical, and alternate wheels (23) take two different positions in relation to the shafts (18). Moreover, when one of the disks (5, 6) is inclined in relation to an adjacent disk, the wheel (23) of the disk most inclined toward the front is farther from the disk (5, 6) than the wheel (23) is from the adjacent disk (5, 6). Moreover, the housing (4) comprises a sliding member (30) which at least partially closes the front part and/or the lower part of the housing (4).
Patent DE-3689851-T2 (DE)
Inventor: OHBA AKIO
IPC: G06T15/00
Filed: 1986-07-25
Granted: 1994-09-08
Abstract: Stereographic free curved surface images such as human faces having various facial expressions can readily be displayed by trial and error in intuitive and interactive manner using computer graphics. In the method, using electronic computing apparatus, a desired deformation area including an action point is designated on a non-deformed surface; a vector field function Fi (deformation rate) is determined at each point within the deformation area; a deformation vector Vi* (deformation quantity and direction) is designated at the action point; and the position vector Pi* (deformed curved surface) is obtained by adding the position vector pi-1* (non-deformed curved surface) to the position vector Vi* * Fi (deformation quantity). The method is applicable to a montage image forming apparatus, a dress design forming apparatus and a decision information displaying apparatus.
Patent DE-3781431-T2 (DE)
Inventor: BUTCHER MILES EDWARD
IPC: H01Q19/10
Filed: 1987-01-13
Granted: 1993-04-22
Abstract: An omnidirectional antenna comprises a ring-shaped subreflector (11) surrounding an omnidirectional feed (10) and a ring-shaped main reflector (12) for redirecting radiation from the subsidiary reflector to the target zone. The feed has a focal ring and a hollow centre to accommodate supports, feeders etc which facilitates stacking of antennas.
Patent DE-3856330-T2 (DE)
Inventor: CHOU TA-SEN
IPC: A61K31/7042
Filed: 1988-08-22
Granted: 1999-09-30
Abstract: The present invention provides a process for preparing lactone intermediates to 2',2'-difluoronucleosides whereby reversion back to the lactone's open chain precursor is minimized and the desired erythro enantiomer can be selectively isolated from an enantiomeric mixture of erythro and threo lactones in crystalline form. Also provided is a process for producing 2'-deoxy-2',2'-difluoronucleosides in about a 1:1 α/β anomeric ratio, and processes for selectively isolating β-2'-deoxy-2',2'-difluorocytidine, or an organic or inorganic acid addition salt thereof, from the 1:1 α/β mixture.
Patent DE-3873828-T2 (DE)
Inventor: MAI JIMBIN
IPC: A23F3/42
Filed: 1988-06-01
Granted: 1993-01-07
Abstract: Aroma and flavour compounds are recovered from plant materials without substantial degradation of the plant material by subjecting the plant material uniformly to microwave radiation in the presence of moisture to release the moisture and aroma and flavour compounds as a vapour, removing the vapour from the plant material as it is formed, and collecting the vapour as a condensate.
Patent DE-3880184-T2 (DE)
Inventor: BARTHELEMY PASCAL
IPC: C08G73/12
Filed: 1988-02-22
Granted: 1993-11-04
Abstract: Novel diorganopolysiloxylated bis(maleimides) which are readily converted into improved heat-stable polymers have the following general formula (I):    <IMAGE>  (I)
Patent TR-199903155-T2 (TR)
Inventor: SEED BRIAN
IPC: C12N15/869
Filed: 1998-04-14
Abstract: Bu bulus, bir memeli hücresinde epizomal çogalmayi destekleyen nükleik asit serileri ile ilgilidir. 3 kb'den daha az bir uzunluga sahip bu nükleik asit serileri, (a)bir silinmis OriP serisi ve (b)bir yükselticiye islevsel olarak baglanmis bir silinmis EBNA1 serisi ihtiva ederler.
Patent AT-E388814-T2 (AT)
Inventor: ANDERSSON THORBJOERN
IPC: B65D81/24
Filed: 2001-10-01
Granted: 2008-03-15
Abstract: The disclosure relates to a packaging laminate for a retortable packaging container comprising a core layer ( 11 ), outer, liquid-tight coatings ( 12 and 13 ) and a gas barrier ( 14 ) disposed between the one coating ( 12 ) and the core layer ( 11 ). Between the gas barrier ( 14 ) and the core layer ( 11 ), there is a layer ( 16 ) of a lamination or sealing agent of such a nature that the lamination or sealing agent has a melting point which is higher than the maximum temperature to which the retortable packaging container is to be subjected during a normal heat treatment in a retort. The lamination or sealing agent in the layer ( 16 ) may, for example, be a polypropylene with a melting point of above 130° C.
Patent DE-60006911-T2 (DE)
Inventor: DUPUIS CHRISTINE
IPC: A61Q19/00
Filed: 2000-08-28
Granted: 2004-09-30
Abstract: Cosmetic composition comprises: <??>(a) Silicone/acrylate copolymer produced by radical polymerization of ethylenically unsaturated monomer in presence of silicone derivative with oxyalkylene groups; <??>(b) Conditioner selected from cationic polymers, cationic and amphiphilic surfactants, aliphatic hydrocarbons, fatty alcohols, esters of fatty acids and alcohols, esters of (di)acids and alcohols, ceramides (analogs). <??>Cosmetic composition comprises: <??>(a) a silicone/acrylate copolymer produced by radical polymerization of an ethylenically unsaturated monomer in the presence of a silicone with oxyalkylene groups; and <??>(b) a conditioner selected from cationic polymers, cationic and amphiphilic surfactants, C8-C300 aliphatic hydrocarbons, C8-C30 fatty alcohols, esters of C8-C30 fatty acids and C1-C30 alcohols, esters of C1-C7 (di)acids and C8-C30 alcohols, ceramides and ceramide analogs. <??>Where the cationic polymers are selected from cellulose derivatives, diallyl dimethyl ammonium halide (co)polymers, methacryloyloxyethyl trimethyl ammonium halide (co)polymers, polyquaternary ammonium polymers, polysiloxanes, polysaccharides and polyamidoamines. <??>Independent claims are also included for: <??>(1) An aerosol device containing the above composition and a propellant gas; <??>(2) Cosmetic method comprising application of the above composition.
Patent DE-60012040-T2 (DE)
Inventor: BARTH FRANCIS
IPC: A61P25/00
Filed: 2000-11-02
Granted: 2005-03-31
Abstract: Tricyclic derivatives of 1-benzylpyrazole-3-carboxylic acid <?img id="CUSTOM-CHARACTER-00001" he="279.40mm" wi="215.90mm" file="US06916838-20050712-P00900.TIF" alt="custom character" img-content="character" img-format="tif" ?>which are antagonists of the cannabinoid CB<SUB>2 </SUB>receptors; their method of preparation and pharmaceutical compositions containing them.
Patent DE-60024240-T2 (DE)
Inventor: BOYKIN JOSEPH V
IPC: A61K31/198
Filed: 2000-03-17
Granted: 2006-07-20
Abstract: Wound healing is impaired in many diabetics, who suffer increased risk of chronic foot ulceration and amputation. Diabetic patients with poor healing ability were found to possess significantly lower fasting urinary nitrate levels than diabetic patients with normal healing ability or non-diabetic controls, implicating decreased endogenous nitric oxide activity as the mediator of diabetes-impaired wound healing. Methods and kits are provided for predicting the wound healing ability of diabetic patients based on the levels of nitric oxide related products such as nitrate or nitrite in urine or other specimens. Methods are also provided for treating non-wound healing diabetics and monitoring diabetic ulcer treatment.
Patent DE-60029583-T2 (DE)
Inventor: CLARKE DAVID
IPC: H03B5/36
Filed: 2000-05-02
Granted: 2007-06-28
Abstract: A crystal oscillator comprises a crystal 1 and a crystal oscillator circuit 3 for providing an output signal 5. In order to adjust the output frequency, for example during the testing stage of production, a bank of load capacitors C1 to C6 are provided. Each capacitor C1 to C6 may be switched into or out of the circuit by a respective switch 9 to 19. The switches are controlled by control lines D0 to D5, which are set by a 6 bit register 21, known as the trim register. The value in the trim register is set according to the frequency of the output signal. To counteract any swing in the output signal, a bank of current switches T1 to T4 are provided, which enable resistors R1 to R4 to be switched into or out of the circuit. Each resistor R1 to R4 is switched by a respective one of the control lines D2 to D5. Thus, adjusting the load capacitance to obtain a desired frequency causes the oscillator core current to be changed automatically, thereby maintaining a constant swing in the output signal.
Patent DE-60030335-T2 (DE)
Inventor: HEINZ THOMAS J
IPC: A61F5/01
Filed: 2000-11-14
Granted: 2007-08-23
Abstract: An orthotic trauma device is provided including an elongated orthosis body adapted to be wrapped around a portion of a body of a wearer of the device, the orthosis body being formed of a pliant material which is adapted to be easily cut with cloth-cutting scissors; a detachable fastening device provided at distal ends of the elongated orthosis body to releasably secure the distal ends to one another; and means for adjusting the tightness of the orthosis body operatively associated with the detachable fastening device. A pulley system for use in an orthotic device is also provided including a pair of pulley banks arranged in juxtaposed relationship, a first bank of which is adapted to be detachably disposed on a first distal end of an elongated orthosis body and a second bank of pulleys adapted to be detachably disposed on a second distal end of the elongated orthosis body; and a cable interconnecting the two pulley banks and running through a pulley on each of the pulley banks in alteration, such that shortening of the cable pulling the pulley banks together and tightening the orthotic device with the aid of a mechanical advantage dependent upon the number of pulleys mounted on each of the pulley banks.
Patent DE-60034084-T2 (DE)
Inventor: MONEREAU CHRISTIAN
IPC: B01D53/053
Filed: 2000-01-05
Granted: 2007-12-06
Abstract: A variable fraction of the residual gas is recycled (between 0 and 30% of the purified gas flow produced) in the impure gas to be treated, with the rest of the residual gas forming a purge, and the duration of the cycle T is reduced when recycling is done, with greater reduction when the recycled fraction is higher  Process for purifying a gas containing impurities which can be preferentially adsorbed, in particular hydrogen, by pressure swing adsorption (PSA) using several adsorbers (1, 2, 3) with each adsorber passing through successive operating phases, out of phase with the other adsorbers by an nth of the cycle duration T, where n is the number of adsorbers. The operating phases are: isobar adsorption at a high pressure of the cycle, with the impure gas being admitted at one end of the adsorber, circulating through it and extraction of the purified gas from the other end; regeneration of the adsorber finishing with at least one stage of extracting a residual gas from the adsorber in back-flow, and raising the pressure back to the high pressure of the cycle. The fraction of gas recycled is temporarily zero and temporarily between 10 and 30% of the purified gas. Gas is recycled when and only when the gas flow produced is greater than a set value. The flow of impure feed gas is kept constant and the amount of recycled gas is varied as a function of the purified gas produced, with the variations in the two gas flows being in the same direction. The reduction in cycle time is between 1 and 30% of the cycle with no recycling. The regeneration starts with a depressurisation stage in back-flow by balancing the pressure with another adsorber which is being repressurised. The regeneration is finished with two final stages: a depressurisation in forward flow to a low pressure and a purge in back-flow. The depressurisation stage by balancing is followed by a second depressurisation stage in forward flow, using the gas from the adsorber during this stage as purge gas. The adsorption unit has three adsorbers and the gas from the adsorber during the second depressurisation stage is sent to an auxiliary purge gas storage, or the adsorption unit has four adsorbers and the gas during the second depressurisation is sent directly to purge in forward flow another adsorber.
Patent DE-60104954-T2 (DE)
Inventor: DINNAGE A
IPC: F24F3/147
Filed: 2001-04-18
Granted: 2005-08-18
Abstract: An apparatus and method for heat and humidity exchange between two air streams, one hot and one humid. A first of the air streams is fed from the interior of a building to the ambient air and a second of the air streams is fed from the ambient air to the interior of the building. The first air stream is cooled and transferred through a heat exchanger, to a heater and a dehumidifier before being exhausted to the ambient air. The second air stream is transferred through the dehumidifier and the heat exchanger, whereupon it is cooled in a cooling device before being transferred into the interior to the building. Before being fed to the dehumidifier, the second air stream is caused to exchange heat and humidity with the first air stream before the latter is fed into the heat exchanger.
Patent DE-60107587-T2 (DE)
Inventor: YOUNSI KARIM
IPC: H02K3/04
Filed: 2001-09-06
Granted: 2005-12-15
Abstract: There is disclosed a groundwall insulation system for use in dynamoelectric machines carrying voltages above 4 kV and preferably in the order of 13.8 kV, or higher. The groundwall insulation comprises two layers of insulation wound onto the conductors of the high voltage winding. The first layer of insulation has a first permittivity that is greater then the permittivity of the second layer of insulation wound onto the first layer of insulation. As a consequence, at the juncture between the first and second layers there is a sharp increase in the electric field profile as seen through the groundwall insulation. This step increase in the electric field profile results in the electric field adjacent the conductor having a maximum magnitude that is less than that normally experienced by insulation systems in the past. By reducing the maximum magnitude of the local electric field profile within the groundwall insulation the life of the insulation and hence the electrical conductor is improved while at the same time permitting a reduction in the thickness of the groundwall insulation.
Patent DE-60112055-T2 (DE)
Inventor: CASTRO PINEIRO LUIS
IPC: A61K38/05
Filed: 2001-02-28
Granted: 2006-04-27
Abstract: Urea derivatives of formula I are disclosed: The compounds are inhibitors of gamma-secretase, and hence useful in the treatment or prevention of Alzheimer's Disease
Patent DE-60117342-T2 (DE)
Inventor: HORNSBY RIDSDALE
IPC: B29C48/92
Filed: 2001-12-11
Granted: 2006-10-19
Abstract: The present invention uses supercritical and near supercritical fluid technology for the processing of polymer-containing formulations without induced foaming, giving benefits of either reduced melt viscosity and/or lower melt temperatures. Its application is particlarly beneficial to difficult to process materials, including unplasticised PVC, polycarbonate, PTFE, UHMWPE and polymers containing high loadings of fillers of organic origin. Shear and thermally sensitive materials can also be processed using this method with less risk of degradation, due to the lower shear input and reduced processing temperatures necessary. The production of foamed ceramic materials and metallic components by such a method is also disclosed.
Patent DE-60129347-T2 (DE)
Inventor: EINOLA HEIKKI
IPC: H04L12/26
Filed: 2001-08-24
Granted: 2008-04-03
Abstract: A method for monitoring a connection to a user terminal in a telecommunications system and a telecommunications system comprising an element (CSCF) controlling a connection to a user terminal (UE) and a system part (SGSN, GGSN) providing transport of user data, which system part is separate from said controlling element, wherein a system element which knows the state of the connection to the user terminal (UE) is arranged to send an indication message to the controlling element (CSCF) indicating the state of the connection, and the controlling element (CSCF) is arranged to decide the state of the connection to the user terminal (UE) based on the indication message received.
Patent DE-60200275-T2 (DE)
Inventor: WEBB ANTHONY KEITH
IPC: B60K15/04
Filed: 2002-01-17
Granted: 2005-02-24
Abstract: The system comprises a diesel fuel filler orifice 12 on the vehicle for receiving diesel fuel from a diesel fuel supply nozzle. The diesel fuel filler orifice 12 is of non-circular cross-section and has a minimum internal dimension which is less than the external diameter of a traditional lead free fuel pump nozzle. A diesel fuel supply nozzle is also disclosed. This supply nozzle has a maximum external dimension greater than the internal diameter of a traditional leaded fuel filler orifice. <IMAGE>
Patent DE-60213609-T2 (DE)
Inventor: REYNOLDS HEULWEN
IPC: C07D239/00
Filed: 2002-07-16
Granted: 2007-08-16
Abstract: The invention relates to a compound of formula (1) in which Q is -CO- or -C(R<SUP>4</SUP>)(R<SUP>5</SUP>)-, where R<SUP>4 </SUP>is a hydrogen atom or C<SUB>1-4</SUB>alkyl and R<SUP>5 </SUP>is a hydrogen atom or hydroxy group; and Ar is a 5- to 10-membered aromatic ring system where up to 4 ring atoms may be heteroatoms independently selected from nitrogen, oxygen and sulphur, the ring system being optionally substituted by one or more substituents as defined in the specification. It also relates to methods of preparing, pharmaceutical compositions containing and methods of using the compound of the formula (1), particularly in the modulation of autoimmune disease.
Patent DE-60213794-T2 (DE)
Inventor: HAADEM KNUT
IPC: A61K31/56
Filed: 2002-06-12
Granted: 2007-02-15
Abstract: The invention concerns a skin preparation for moistening human skin comprising a combination of a component A and a component B, wherein A includes at least two saturated C<SUB>9</SUB>-C<SUB>31 </SUB>fatty acids selected from the group consisting of iso- and anteiso fatty acids, whereby component B consists of cholesterol in an amount of 5-15% by weight of component A.
Patent DE-60220491-T2 (DE)
Inventor: GUZZINI GIANNUNZIO
IPC: F21V3/00
Filed: 2002-12-13
Granted: 2008-01-31
Abstract: Lighting equipment with a differentiated luminous effect, in particular for creating pre-selected luminous effects, comprises an external containment body (12, 12a, 12b) suitable for housing at least one luminous source (13), wherein said at least luminous source (13) is sustained by a relative supporting base (14), wherein said external body (12) has a rounded and transparent form and includes at least two series of localized areas (16, 17, 18, 19) with differentiated transparency for the emission of various intensities of light. Said series of areas (16, 17, 18) are preferably arranged along sectors of the rounded external body. Moreover, the external body (12) also contains a perimeter zone where there is at least a further annular portion (19) with a differentiated transparency with respect to the cited at least two series of localized areas, all of the above allowing a particular and variously arranged light diffusion emitted by the internal luminous source (13). <IMAGE>