Patent AU-2012327200-B2 (AU)
Title: Binding molecules for BCMA and CD3
Inventor: KUFER PETER
IPC: C07K14/00
Filed: 2012-11-15
Granted: 2016-01-21
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/072406 Al 23 May 2013 (23.05.2013) W I PO I P CT (51) International Patent Classification: gen Research (Munich) GmbH, Staffelseestr. 2, 81477 Mu C07K 16/28 (2006.01) A61P 35/02 (2006.01) niche (DE). KISCHEL, Roman; c/o Amgen Research (Mu A61K39/395 (2006.01) A61P 37/00 (2006.01) niche) GmbH, Staffelseestr. 2, 81477 Munich (DE). LUT (21) International Application Number: TERBUESE, Ralf; c/o Amgen Research (Munich) GmbH, PCT/EP2012/072699 Staffelseestr. 2, 81477 Munich (DE). RAU, Doris; c/o Amgen Research (Munich) GmbH, Staffelseestr. 2, 81477 Mu (22) International Filing Date: nich (DE). ADAM, Paul; c/o Boehringer Ingelheim 15 November 2012 (15.11.2012) GmbH, Corporate Patents, Binger Strasse 173, 55216 In gelheim am Rhein (DE). BORGES, Eric; c/o Boehringer (25) Filing Language: English Ingelheim GmbH, Corporate Patents, Binger Strasse 173, (26) Publication Language: English 55216 Ingelheim am Rhein (DE). HEBEIS, Barbara; c/o Boehringer Ingelheim GmbH, Corporate Patents, Binger (30) Priority Data: Strasse 173, 55216 Ingelheim am Rhein (DE). HIPP, 61/560,144 15 November 2011 (15.11.2011) US Susanne; c/o Boehringer Ingelheim GmbH, Corporate Pat 61/560,149 15 November 2011 (15.11.2011) US ents, Binger Strasse 173, 55216 Ingelheim am Rhein (DE). 61/560,162 15 November 2011 (15.11.2011) US 61/560,178 15 November 2011 (15.11.2011) US (74) Agents: WEINZIERL, Gerhard et al.; Schiweck Weinzi 61/560,183 15 November 2011 (15.11.2011) US erl Koch, European Patent Attorneys, Landsberger Str. 98, 61/651,486 24 May 2012 (24.05.2012) US 80339 Munich (DE). 61/651,474 24 May 2012 (24.05.2012) US (81) Designated States (unless otherwise indicated, for every (71) Applicants: AMGEN RESEARCH (MUNICH) GMBH kind of national protection available): AE, AG, AL, AM, [DE/DE]; Staffelseestr. 2, 81477 Munich (DE). AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BOEHRINGER INGELHEIM INTERNATIONAL BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, GMBH [DE/DE]; Binger Strasse 173, 55216 Ingelheim DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, am Rhein (DE). HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, (72) Inventors: KUFER, Peter; c/o Amgen Research (Munich) ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, GmbH, Staffelseestr. 2, 81477 Munich (DE). RAUM, To- NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, bias; c/o Amgen Research (Munich) GmbH, Staffelseestr. RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, 2, 81477 Munich (DE). HOFFMANN, Patrick; c/o Am [Continued on next page] (54) Title: BINDING MOLECULES FOR BCMA AND CD3 Figure 16 2200- w/Treatment (Days 13-29) 220 4Group 1: Vehicle w/o T cells (iv.) 2000 * roup 2: Vehicle (iv.) Group 3: BCMA-98 x CD3 (0.5 mglkgld, i.v.) 1800 0 Group 4: BCMA-34 x CD3 (0.5 mgkg/d, iv.) S> 1000 E A 600.j 4 6 D 1 12 1 4 1 6 18 20'( 2 2 24 2C6 29 3 Day of experiment (57) Abstract: The present invention relates to a binding molecule which is at least bispecific comprising a first and a second bind ing domain,wherein the first binding domain is capable of binding to epitope cluster3 of BCMA,and the second binding domain is f4 capable of binding to the Tcell CD3 receptor complex. Moreover, the invention provides a nucleic acid sequence encoding the bind ing molecule, a vector comprising said nucleic acid sequence and a host cell transformed or transfected with said vector. Further more, the invention provides a process for the production of the binding molecule of the invention, a medical use of said binding molecule and a kit comprising said binding molecule. W O 2 0 13 /0 7 2 4 0 6 A 1 l llll||ll l lll lll l I||||||||||||||||||||||I||||||||||||||||||||||||||||||||||||||||| TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, ZM, ZW. GW, ML, MR, NE, SN, TD, TG). (84) Designated States (unless otherwise indicated, for every Published: kind of regional protection available): ARIPO (BW, GH ' with international search report (Art. 21(3)) GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, - before the expiration of the time limit for amending the TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, claims and to be republished in the event of receipt of EE, ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, amendments (Rule 48.2(h)) LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK,