baber/WOPTO huggingface dataset:
Patent IE-34407-L (IE)
Title: Preparing 7-aminocephalosporanic acid
IPC: C07D501/02
Filed: 1970-06-16
Abstract: 1313207 Preparing 7-amino-cephalosporanic acid; N-haloalkanoylcephalosporins ELI LILLY & CO 24 June 1970 [26 June 1969] 30753/70 Heading C2A [Also in Division C3] 7-Amino-cephalosporanic acid is prepared from cephalosporin C by acylating the amino group in the adipamyl side chain with an α- halo- or α,α-dihalo-C 2 to C 4 alkanoyl group, protecting the carboxyl groups, treating with a halogenating agent to convert the amido group in the 7-position to an imino halide, converting the imino halide to an imino ether, hydrolysing the imino ether and if necessary, removing the carboxyl-protecting groups, to give 7-aminocephalosporanic acid. The amino group is preferably acylated with a chloroacetyl group, suitably while the cephalosporin C is still in the preparative fermentation broth. The N-haloalkanoyl derivative is extracted with waterimmiscible solvent (e.g. alkyl esters preferably with 1/10 volume of alkanol) and precipitated from the extract as a salt. The preferred salt is an amine salt, since the subsequent reaction for protecting the carboxyl groups proceeds more rapidly with better yields if an amine salt is used. The carboxyl groups arc protected by esterification, preferably as a silyl ester by treatment with an alkylchlorosilane. The imino halide is formed by reaction with a halogenating agent such as a chloride or oxychloride of phosphorus, sulphur or carbon, preferably phosphorus pentachloride, and is converted to the imino ether by reaction with an alcohol, a phenol or a sulphydryl compound, e.g. npropanol. The imino ether is hydrolysed or alcoholysed by treatment with water or an alcohol under mildly acidic or basic conditions; this treatment may also remove the carboxylprotecting ester groups, or alternatively they may be removed by other conventional procedures, e.g. hydrogenolysis. Novel N - α - haloalkanoyl cephalosporins having the formula wherein R is an α-halo- or α,α-dihalo-C 2 to C 4 alkanoyl group and X is hydrogen or C 1 -C 4 alkyl, C 4 -C 8 t-alkyl, C 5 -C 8 t-alkenyl, C 5 -C 8 talkynyl, phenacyl, trichloromethyl, benzyl, benzhydryl, p-methoxybenzyl, p-nitrobenzyl, trityl, trimethylsilyl, dimethylsilyl, methylsilyl, triethylsilyl, diethylsilyl, or ethylsilyl, and the alkali metal, alkaline earth metal, quinoline, cyclohexylamine, 5-ethyl-2-methylpyridine, 2-, 3- or 4-picoline, N-ethyl or N-methylmorpholine, 2,6-lutidine, N,N-diethylcyclohexylamine, hexamethylenetetramine, N,N - dimethylbenzylamine or N,N-dibenzylethylenediamine salt thereof when one or both X groups are hydrogen, are prepared by treating cephalosporin C with an appropriate haloacyl halide or mixed anhydride and if required, salifying the product. Reference has been directed by the Comptroller to Specification 1,041,985.
[GB1313207A]
Patent IE-780844-L (IE)
Title: Haloarylmalonamidooxacephalosporins
IPC: C07C59/56
Filed: 1978-04-28
Abstract: Antibacterial haloarylmalonamido-1-dethia-1-oxacephalosporins of the following formula: <IMAGE> wherein Ar is <IMAGE> <IMAGE> +TR <IMAGE> (in which Hal and Hal' each is halogen and RO is hydroxy or protected hydroxy); COA and COB each is carboxy or protected carboxy including a pharmaceutically acceptable salt group; and Het is 1-lower alkyl-5-tetrazolyl, 1,3,4-thiadiazol-2-yl or 5-lower alkyl-1,3,4-thiadiazol-2-yl, a pharmaceutical or veterinary composition comprising the said haloarylmalonamido-1-dethia-1-oxacephalosporin and pharmaceutical carrier, and a method for treating or preventing human or veterinary infectious diseases comprising administering an effective amount of the said antibacterial compound.
[US4183928A]
Patent FI-803190-L (FI)
Inventor: SLIWKA WOLFGANG
IPC: B01J13/02
Filed: 1980-10-08
Abstract: In a process for the preparation of microcapsules based on a melamine-formaldehyde resin, in which the microcapsules are obtained by condensing a melamine-formaldehyde precondensate, its C1-C4-alkyl ethers, or mixtures thereof, in water in which the material forming the capsule core is dispersed, at a pH of from 3 to 6.5 and at from 20 DEG  to 100 DEG  C., the improvement that the water contains a homopolymer or copolymer which possesses sulfonic acid groups but is devoid of phenyl or sulfophenyl groups and has a K value of from 100 to 170 or a viscosity of from 200 to 5,000 mPa.s (shearing gradient 489 s-1; 20% strength solution at 25 DEG  C.), and that the melamine-formaldehyde precondensate is added continuously, or in portions, in step with the rate of condensation. The process gives individual capsules which are highly impermeable. The capsules are exceptionally useful for the production of pressure-sensitive recording materials.
Patent FI-850519-L (FI)
Inventor: SKUBALLA WERNER
IPC: C07C405/00
Filed: 1985-02-07
Abstract: Carbacyclins of Formula I    <IMAGE>  (I)  wherein R1 is an alkyl, cycloalkyl, aryl, aralkyl, or heterocyclic group, Y is a keto group or a hydroxymethylene group, X is a -CH2- group or an oxygen atom, A is a -CH2-CH2-, a trans-CH=CH- or a -C 3BOND C- group, W is a hydroxymethylene group or a   <IMAGE>  D is the group   <IMAGE>   a straight-chain or branched, saturated alkylene group or unsaturated alkylene group of up to 5 carbon atoms which can optionally be substituted by 1-2 fluorine atoms, n is 1, 2 or 3, E is a direct bond, a -C 3BOND C- group or a -CR4=CR5- group wherein R4 is hydrogen or an alkyl group and R5 is hydrogen, halogen or an alkyl group, R2 is an alkyl, cycloalkyl, aryl, or heterocyclic group, and R3 is a hydroxy group, are valuable, e.g., as cytoprotective agents.
Patent FI-854025-L (FI)
Inventor: KELLER REINHOLD
IPC: C12P41/00
Filed: 1985-10-16
Abstract: 1. A process for the preparation of aromatically substituted L-amino acids by enzymatic cleavage of the racemate of the lower alkyl esters (except tert.-butylester) using alpha-chymotrypsin in the weakly acid pH range and extraction of the ester of the D form, which comprises the reaction mixture obtained in the enzymatic cleavage being made weakly alkaline, the ester of the D-amino acid being extracted from this alkaline solution using an organic solvent, and being racemized, whereupon the racemate is returned to the process, and the extracted alkaline solution being made weakly acid, whereupon the L-amino acid is isolated from it.
Patent IE-32954-L (IE)
Title: Pipe couplings
IPC: F16L5/00
Filed: 1968-09-20
Abstract: 1,220,249. Pipe couplings. PLASTIC OMNIUM. 19 Sept., 1968 [21 Sept., 1967], No. 44695/68. Heading F2G. Connecting means for providing a detachable waterproof connection between a pipe 1 and a pipe 2 of smaller cross-section than the pipe 1, comprises an element 4 of resilient material, such as natural or synthetic rubber or a plastics material, having a peripheral portion engageable with the end of the pipe 1 and a member 3 adapted to form a snap fit with an external flange 8 provided on the pipe 1 to secure the element 4 against the end surface of the pipe. The element 4 comprises a continuous lip 5 adapted to engage the inner surface of the pipe 1, an aperture into which the pipe 2 can be inserted and an integrally formed collar 12 extending around the aperture, the collar being arranged to grip the pipe 2. As shown, the element is formed with collars 12, 12<SP>1</SP> each having internal ribs 14, and the member 3 has apertures which register with the collars and the peripheries of which are engaged by flanges 13, 13<SP>1</SP> of the collars; the member 3 has a rim 17 provided with internal spaced projections 9 which snap over the flange 8.
[GB1220249A]
Patent IE-791178-L (IE)
Title: Dioxolanylmethylazoles
IPC: A61K31/495
Filed: 1979-08-08
Abstract: The compounds have antifungicidal and antimicrobial activity and are used in medicine. They are selected among a group of azole derivatives having the general formula (formula) where their substitute have the respective meanings. The invention is also related to pharmaceutically acceptable acid-adjoint salts and stereochemical isomer forms of the compounds.
[BG60430B2]
Patent IE-781274-L (IE)
Title: Exposing worn carbide tips in drill bits
IPC: E21B12/00
Filed: 1978-06-26
Abstract: A device for exposing worn button pegs in drill bits comprising a milling head (1) with an axial recess (3) accommodating a centering pin (2) displaceable in the axial direction of the milling head. Said pin has an inner end (5) acted on by a compression spring means (4), and an outer end projecting from the milling head. The outer end (8) of the centering pin has a bowl-shaped recess (9) with a shape which is preferably hemispherical and corresponds to the shape of the button end of the carbide peg extending out of the drill bit. The button end of said peg is enclosed by the bowl-shaped recess when exposing the body portion of the peg. <IMAGE>
[SE7707478L]
Patent IE-841329-L (IE)
Title: Device for gripping containers
IPC: B65G1/04
Filed: 1984-05-28
Abstract: 1. A device for retrieving containers and driving them horizontally along a handling platform, comprising at least one endless flexible member (2) actuated horizontally by several pinions mounted on the platform and driven by a motor, the said flexible member (2) being equipped with at least two fingers (9a, 9b) designed to interact with receiving means (10) provided on the two front sides (5) of a container (1), one of the fingers (9a) acting by pull and the other (9b) by thrust on said container (1), characterized in that the two fingers (9a, 9b) occupy, transversely to the longitudinal axis of said flexible member (2), an identical position in that the course oi the flexible member is defined by two groups each of three pinions (3a, 3b, 3c) and (4a, 4b, 4c) interacting with said flexible member (2), the pinions of each group, taken in pairs (3a, 3b), (3b, 3c) and (4a, 4b), (4b, 4c), being aligned along an axis which is neither parallel to the front faces (5) of the containers (1), nor parallel to the direction (6) in which said containers are driven, the axes of alignment of the pinions converging towards the central portion of the platform, and in that the flexible member (2) interacts with the intermediate pinions (3b, 4b) by means of its outer face (8) and with the pinions closest to each other (3c, 4c) by means of its inner face (7), in such a way that the section of the flexible member between each intermediate pinion (3b, 4b) and the pinion adjacent thereto (3c, 4c) is perpendicular to the direction of displacement of the container, so that, starting from a first storage position of the container (1) the pulling finger (9a) stops driving the container momentarily to allow engagement of the thrusting finger (9b) inside the other receiving means (16) of the container, driving of the container (1) then continuing with the aid of the two fingers (9a, 9b), and so that at another given point in the course of the flexible member (2) the thrusting finger (9b) momentarily stops driving the container (1) so as to allow disengagement of the pulling finger (9a) from its receiving means (10), the thrusting finger (9b) then driving the container (1) alone to another storage position, where it in turn disengages from its receiving means (16).
Patent IE-831384-L (IE)
Title: Benzazepines.
IPC: C07D233/16
Filed: 1983-06-13
Abstract: The invention relates to 1-aryloxy-2,3,4,5-tetrahydro-3- benzazepines of the formulawherein Y, and Y<sub>2</sub> are the same or different and are hydrogen or lower alkoxy; X is hydrogen, halogen, lower alkyl, lower alkoxy, CF<sub>3</sub>, NO<sub>2</sub>, CN and NH<sub>2</sub>; R is hydrogen, lower alkyl, cycloatkyllower alkylAr lower alkyl of the formula -alkylenewhere Z is hydrogen, lower alkyl, lower alkoxy, halogen, CF<sub>3</sub>, NO<sub>2</sub>; and NH<sub>2</sub>; and an alkylene amine of the formula -alkylenewhere R, and R<sub>2</sub> are the same or different and are hydrogen and lower alkyl and the alkylene moiety is of 1 to 6 carbon atoms, and the pharmaceutically acceptable acid addition salts thereof.
Patent IE-40158-L (IE)
Title: Vertebral endoprosthesis.
IPC: A61F2/44
Filed: 1974-07-18
Abstract: A surgical implant is produced by coating a metallic substrate with enamel. The metallic substrate provides structural strength and the enamel provides chemical stability, resistance to wear, tissue compatibility, progressive ingrowth and electrical insulating properties. The implant may be produced by coating a portion of the metallic substrate with a partially crystallized enamel, and then positioning the implant on a firing support with the partially crystallized enamel in contact with the support and coating the remaining non-enamelled surface.
[US4044170A]
Patent IE-791669-L (IE)
Title: Preparation of gels
IPC: A23L21/10
Filed: 1979-09-03
Abstract: Edible alginate and low-methoxy-pectate gels are produced by rapidly mixing aqueous slurries containing finely divided foodstuff and particles of sparingly soluble solid, e.g. calcium sulphate, capable of releasing gelling agent into solution, throughout gellable aqueous alginate or low-methoxy-pectate sols, and then under shear-free conditions allowing the solid to release the gelling agent, e.g. calcium ions so that the mixture can gel.
[US4347261A]
Patent IE-811741-L (IE)
Title: Semiconductor read only memory device
IPC: G11C17/18
Filed: 1981-07-30
Abstract: A semiconductor read only memory device comprises bit lines, word lines, a load transistor, a multiplexer including a plurality of transistors, and a memory cell array in which each memory cell has one transistor having a gate connected to one of the word lines and corresponding to one of the bit lines connected to the transistors of the multiplexer. A gate transistor is inserted between the load transistor and the multiplexer, and a gate voltage control circuit, for selectively providing a higher level signal and a lower level signal, is connected to the gate transistor.
[US4447893A]
Patent IE-811912-L (IE)
Title: Tricyclic compounds.
IPC: C07C45/68
Filed: 1981-08-20
Abstract: Tricyclic imidazole derivatives of the formula <IMAGE> I wherein R1 is 2-pyridyl optionally substituted by lower alkyl or lower alkoxy, n is the integer 0 or 1, R2 is hydrogen or lower alkyl, R3 and R4, independently, are hydrogen or lower alkyl, A is a group of the formula <IMAGE> <IMAGE> +TR <IMAGE> m is the integer 2 or 3, R5, R6, R7 and R8, independently, are hydrogen or lower alkyl, and R9 is hydrogen and R10 is hydrogen or lower alkyl or R9 and R10 taken together are oxo, provided that at least one of R3 and R4 is lower alkyl when A is a group of the formula -CH=CH-CH=CH- or -(CH2)4-, and their pharmaceutically acceptable acid addition salts. The compounds of formula I inhibit gastric acid secretion and prevent the formation of gastric ulcers.
[US4435406A]
Patent IE-812142-L (IE)
Title: Cyclopropane carboxamidoalkenoic acids and esters
IPC: C07D239/56
Filed: 1981-09-15
Abstract: Novel chemical compounds and a process for preparing them are provided. These compounds selectively inhibit the metabolism of dipeptidase (E.C.3.4.13.11) and therefore are useful in combination with antibacterial products. These chemical compounds are Z-2-(2,2-dimethylcyclopropanecarboxamido)- omega -pyridylthio-2-alkenoic acids (and related arylthio and heterocyclylthio analogs) of the general formula: <CHEM> wherein n is an integer from 3-5, Y is pyridyl, pyrimidinyl, tetrazolyl, imidazolyl, thiadiazolyl, thiazolinyl, or phenyl, optionally having 1 or 2 substituents which are hydroxyl, oxo, carboxyl, or methyl; and the loweralkyl (C1-6) esters and pharmaceutically acceptable salts thereof.
Patent IE-822212-L (IE)
Title: Foundry binder composition
IPC: C08G65/14
Filed: 1982-09-09
Abstract: A composition which contains certain epoxidized materials and/or prepolymers thereof, and an acidic catalyst; and use thereof.
[US4390675A]
Patent IE-843119-L (IE)
Title: Imidazoquinolines and related heterocyclics
IPC: C07D487/06
Filed: 1984-12-05
Abstract: The invention provides a compound of formula I <IMAGE> I wherein A is a C1-C4 straight or branched alkylene chain which may be saturated or unsaturated, B is a C2-C4 straight or branched alkylene chain which may be saturated or unsaturated, Ar is a phenyl or naphthyl group which may be substituted or unsubstituted, R1 and R2 are the same or different and are hydrogen, alkyl, alkoxy, alkoxyalkyl, hydroxyalkyl, hydroxy, halogen, nitro, carboxy, a carboxylic alkyl ester, carbamoyl, carbamoyloxy, cyano, acyl, acylamino or trifluoromethyl, or an acid addition salt thereof. The compounds are useful for the treatment of ulcers or hypersecretion in mammals. Pharmaceutical compositions containing the novel compounds and processes for their preparation are described.
[US4609655A]
Patent NO-790291-L (NO)
Title: Tannskaanende, vannfattig, sukkerholdig naeringsmiddel og farmasoeytisk formulering
Inventor: LEMBKE ANDREAS
IPC: A21D2/18
Filed: 1979-01-30
Abstract: Tannskånende, vannfattige, sukkerholdige næringsmidler og tannskånende, vannfattige farmasøytiske preparater
Patent NO-803012-L (NO)
Inventor: CAMERON ERMA C
IPC: C12Q1/28
Filed: 1980-10-09
Abstract: A composition, test device, method of making a test device and process for determination of an analyte in a liquid sample are disclosed. More particularly, there is provided a composition for the determination of an analyte in a sample which composition comprises an analyte-responsive component comprising a pyridine nucleotide susceptible of reduction in response to the presence of the analyte, an uncoupler effective to generate an oxidizing substance from the reduced form of said pyridine nucleotide, a peroxidatively active substance, and an indicator which, when oxidized, is not susceptible to reduction by said reduced pyridine nucleotide. The pyridine nucleotide is either nicotine adenine dinucieotide (NAD) or nicotine adenine dinucleotide phosphate (NADP).
Patent NO-821724-L (NO)
Inventor: BILLARD ALAIN ANDRE ARISTIDE
IPC: B64D1/16
Filed: 1982-05-25
Abstract: In an ejection cavity defined by walls such as (753 and 754), an open decoy support body (70) in the form of a slide is placed, and equipped with a pyrotechnic ejection charge (709) and a transmitter (761) for igniting the ejection charge on command. In addition to the stopper (755) which closes the ejection orifice of the cavity, a retaining member (750) is provided, comprising along its edge V-shaped clips (751), whereof the point is directed towards the inside of the decoy launching cavity and keeps the decoys in place despite the high accelerations and vibrating stresses encountered in an aircraft. At the time of deployment of the decoy, the sliding of the slide will disengage the V-shaped clips (751), which allows a slow departure of the decoy support member.
Patent NO-864097-L (NO)
Inventor: MERRIAN CHARLES NEALE
IPC: C09D133/04
Filed: 1986-10-14
Abstract: Vinyl chloride copolymers including a hydroxyalkyl acrylate or methacrylate or allyl alcohol, an epoxy-containing vinyl monomer and an acid functionality from either certain carboxylic acid-containing monomers or a phosphorus ester moiety in selected proportions provide suitable binder resins for applications such as magnetic recording media, imparting desirable thermal stability together with enhanced dispersion and magnetic property characteristics and miscibility with elastomers employed in such media.
Patent NO-882453-L (NO)
Inventor: MULVIHILL EILEEN R
IPC: A61K38/00
Filed: 1988-06-03
Abstract: Tissue plasminogen activator analogs exhibiting greater specificity for fibrin than native t-PA are disclosed. The analogs include the K1 domain of native t-PA replaced with another kringle domain mediating the binding of the analog to fibrin. The kringle contains six cysteine residues. The t-PA analogs may further include a variety of substitutions and modifications. Pharmaceutical compositions containing one or more of the t-PA analogs along with a physiologically acceptable carrier or diluent are also disclosed.
Patent NO-882714-L (NO)
Inventor: TOIVITO ILKKA
IPC: A47C27/10
Filed: 1988-06-20
Abstract: The invention relates to an air mattress (1) comprising a number of successive, elongate and bag-like elements, which can be filled with gas such as air or with some other flowing medium. The elements are arranged transversally with respect to the lengthwise axis (D - D) of the mattress and/or the bed, and are connected to each other successively in a band-like fashion. The successive elements (2, 2 min ) are arranged so that the lenghtwise seam joints (6; 6b) of the elementes are located at given intervals in the bottom part (1b) of the mattress, and that the areas between these seam joints are arranged to form structures which are directed upwards from the bottom part (1b) of the mattress. The invention also relates to a method for adjusting an air mattress or the like. The elements (2, 2 min ; 9, 10) of the mattress are partly filled with for instance air, so that the mattress pressure corresponds to the pressure of the surroundings when the mattress elements are not subjected to a weight load, but the mattress pressure grows in a known fashion according to the weight load of the human body or part thereof, so that the mattress elements conform to the contours of the body or part thereof, and simultaneously the surface pressure against the body or part thereof is distributed evenly over the whole body or part thereof.
Patent NO-883516-L (NO)
Inventor: SCHUERLE HERMANN
IPC: B44B7/00
Filed: 1988-08-08
Abstract: In order to produce the identification and/or mark, those regions on the surface of the spectacle lens (16) which represent the shape of the identification and/or mark are irradiated using an excimer laser (11) through a mask (13, 23) which contains the identification (33) and/or mark (43) as recesses (32). 
<IMAGE>
Patent NO-890271-L (NO)
Inventor: SEQUEIRA JOEL A
IPC: A61K9/00
Filed: 1989-01-20
Abstract: An improved lotion formulation for the topical administration of corticosteroids in a hydro-alcoholic base containing propylene glycol.
Patent NO-903051-L (NO)
Title: Anordning og fremgangsmaate for kompostering av kjoekkenavfall.
Inventor: GREPPERUD EINAR
IPC: C05F/
Filed: 1990-07-09
Abstract: Kompostbeholder (6) og fremgangsmåte ved formuldning av kjøk-kenavfall o.l., hvor det blir sørget for den nødvendige lufttilgang i kompostbeholderen ved hjelp av kanaler (3) inne i beholderen, og hvor det med kanalens form og plassering blir sørget for riktig lufttilgang i prosessens forskjellige faser. I veggene fra bunnen og opp til toppen er en rekke vannrett-gaende innbuktninger (1) som er forbundet med opprettstaende kanaler (3), slik at innbuktningene er sikret en kontinuerlig lufttiIgang.Samtidig bevares kompostens fuktighet ved at det er en minimal luftutveks1 ing med omgivelsene ved at lokket har regulerbar mer eller mindre tett slutning (4). Den løse nettingbunnen muliggjør utveksling av meitemark, sopper og bakterier mellom jord og kompost, mens skadedyr hindres i å komme inn. Den løse bunnen tillater en enkel tømming av beholderen. Varmeisolasjon (7) av beholder og lokk letter en gunstig temperaturutvikling i komposten gjennom årstidene, og jord- og hydratkalkti1 setning () i forbindelse med fylling av kjøkke-navfall mm. fremmer denskede prosesser, samtidig som mulig-heten for utvikling av ubehagelig lukt blir sterkt redusert.