Patent SG-11201907334Q-A (SG)
Title: Therapeutic dendrimers
Inventor: MCCOULL WILLIAM
IPC: C08G83/00
Filed: 2018-02-22
Abstract: BU)—(BU2)2 — — (BUx) 2 (. Core A Building Unit in the Outermost Generation Gor e Building Unit Dendron Surface Functional Groups Figure 1 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 30 August 2018 (30.08.2018) WIPO I PCT mu °million °nolo HE ioo Ho ino Immo oimIE (10) International Publication Number WO 2018/154004 Al (51) International Patent Classification: A61K 47/60 (2017.01) CO8G 83/00 (2006.01) C08G 6 9 / 1 0 (2006.01) A61P 35/00 (2006.01) C08G 6 9 / 4 0 (2006.01) (21) International Application Number: PCT/EP2018/054420 (22) International Filing Date: 22 February 2018 (22.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/461,983 22 February 2017 (22.02.2017) US 62/488,151 21 April 2017 (21.04.2017) US 62/591,823 29 November 2017 (29.11.2017) US (71) Applicant: ASTRAZENECA AB [SE/SE]; 151 85 Sodertalje (SE). (72) Inventors: MCCOULL, William; AstraZeneca R&D, Macclesfield Cheshire SK10 4TG (GB). ASHFORD, Mar- ianne, Bernice; AstraZeneca R&D, Macclesfield Cheshire SK10 4TG (GB). GRANT, lain; AstraZeneca R&D, Mac- clesfield Cheshire SK10 4TG (GB). HENNESSY, Ed- ward, John; AstraZeneca R&D Boston 35 Gatehouse Drive, Waltham, Massachusettes 02451 (US). SECRIST, John, Paul; AstraZeneca R&D Boston 35 Gatehouse Dri- ve, Waltham, Massachusettes 02451 (US). OWEN, David; Starpharma Pty Limited 4-6 Southhampton Cresent, Ab- botsford, Victoria 3067 (AU). KELLY, Brian; Starpharma Pty Limited 4-6 Southampton Cresent, Abbotsford, Victoria 3067 (AU). GIANNIS, Michael; Starpharma Pty Limited 4-6 Southampton Cresent, Abbotsford, Victoria 3067 (AU). (74) Agent: STORM, Peter, Jan; AstraZeneca Intellectual Property Milstein Building, Granta Park, Cambridge Cam- bridgeshire CB21 6GH (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (54) Title: THERAPEUTIC DENDRIMERS 1-1 (57) : Disclosed are dendrimers of formula (I): and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceu- tical compositions comprising the dendrimer of formula (I) and methods of using the same for treating cancer. C [Continued on next page] WO 2018/154004 Al MIDEDIMOMMIONE10131100HONIIMEMOVH SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) Published: — with international search report (Art. 21(3))