baber/WOPTO huggingface dataset:
Patent PT-665886-E (PT)
Inventor: SCHULT DAVID H
IPC: C12Q1/68
Filed: 1993-10-18
Abstract: A method and diagnostic kit for diagnosing transformation of a cell, involving detection of the subunit components of cyclin complexes, is disclosed. In particular, the method pertains to the interaction of cyclins, PCNA, CDKs, and low molecular weight polypeptides such as p21, p19 and p16. The invention further pertains to inhibitors of cell proliferation.
Patent PT-675943-E (PT)
Inventor: HARMALKER SUBHASH
IPC: C11D3/20
Filed: 1993-12-20
Abstract: This invention relates to fabric conditioning compositions containing inorganic acid salts of defined amidoamine compounds in combination with a carboxylic acid, which compositions are characterized by superior environmental compatibility relative to conventional quaternary ammonium fabric softening compositions concomitant with providing improved calcium salt solubilization and reduction of encrustation on treated fabrics.
Patent PT-644773-E (PT)
Inventor: TOROSSIAN FERNAND NARBEY
IPC: A61K35/74
Filed: 1994-02-18
Abstract: An immunomodulator complex for inhibiting intracellular replication of HIV retrovirus comprises cellular membrane fractions from at least one bacterial microorganism, and ribosomal RNA of that microorganism. The ribosomal RNA is covalently coupled to a glycoprotein amino acid sequence of type III collagen.
Patent PT-731091-E (PT)
Inventor: YAMADA KOICHIRO
IPC: C07D209/42
Filed: 1994-11-25
Abstract: Disclosed is a 2-oxoindoline derivative represented by the formula (I): <CHEM> (wherein Ring A represents a substituted or unsubstituted benzene ring, R<1> represents H, a cycloalkyl group, an aryl group, a nitrogen-containing heterocyclic group, an oxygen-containing heterocyclic group, a sulfur-containing heterocyclic group, a heterocyclic group containing N and O, a heterocyclic group containing N and S, a lower alkoxy group, a carboxyl group, cyano group, a lower alkylthio group, a lower alkylsulfinyl group, a lower alkylsulfonyl group, an oxiranyl group or a 2-(lower alkylthio)-1-hydroxyethyl group, R<2> represents an aryl group, a group represented by the formula: <CHEM> a substituted or unsubstituted nitrogen-containing heteromonocyclic group, a substituted or unsubstituted nitrogen-containing heterobicyclic group, a group represented by the formula: <CHEM>  (wherein n represents 1 or 2.), an oxygen-containing heterocyclic group, a sulfur-containing heterocyclic group, a heterocyclic group containing N and O or a heterocyclic group containing N and S, R<3> represents a substituted or unsubstituted lower alkyl group, Q represents a single bonding arm or a lower alkylene group, Y represents a single bonding arm, a lower alkylene group or a lower alkenylene group.), and a pharmaceutically acceptable salt thereof.
Patent PT-721782-E (PT)
Inventor: ROBERTS MARK
IPC: A61K39/00
Filed: 1996-01-09
Abstract: The invention provides a vaccine composition comprising an effective immunogenic amount of an influenza antigen and an effective adjuvant amount of a non-toxic mutant form of pertussis toxin. The influenza antigen preferably comprises haemagglutinin and neuraminidase antigens, and in particular purified haemagglutinin and neuraminidase antigens. The non-toxic mutant form of pertussis toxin may be one in which the Glu 129 amino acid in the S1 sub-unit has been substituted by another amino acid, for example by glycine, and the arginine 9 amino acid residue has been substituted by another amino acid, for example by lysine. <IMAGE>   <IMAGE>
Patent PT-772451-E (PT)
Inventor: KOLTERMAN ORVILLE G
IPC: A61K38/23
Filed: 1996-06-07
Abstract: Methods for treating non-insulin-taking Type II diabetes mellitus which comprise administering a therapeutically effective amount of an amylin agonist.
Patent PT-848626-E (PT)
Inventor: POURCHEZ THIERRY
IPC: A61M25/14
Filed: 1996-09-04
Abstract: PCT No. PCT/FR96/01346 Sec. 371 Date Mar. 9, 1998 Sec. 102(e) Date Mar. 9, 1998 PCT Filed Sep. 4, 1996 PCT Pub. No. WO97/09086 PCT Pub. Date Mar. 13, 1997A multilumen catheter (1) of a type comprising two inner lumens (2, 3) defined by a wall (2A, 3A) for guiding a fluid (4), and two opposite ends (5, 6), namely a distal end (5) and a proximal end (6), characterized in that the distal end is formed of two elongated and discrete end portions (13, 14) located beyond a so-called dividing point (12) at a predetermined distance D1 from the proximal end (6), wherein said end portions, in a rest position of the catheter, extend parallel to the longitudinal axis thereof, each over a predetermined length (L1, L2) measurable between a free end (13A, 14A) and the dividing point (12), are each made of a flexible material, contain a segment of at least one lumen (2, 3) and have at least one channel (7, 8) for delivering and/or sampling the fluid.
Patent PT-876817-E (PT)
Inventor: NAKATA KATSUHIKO
IPC: A61K9/06
Filed: 1997-01-17
Abstract: A novel substance promoting the production and secretion of mucin in ocular tissues. A remedy for keratoconjunctival diseases containing gefarnate as the active ingredient and being applicable to dry eyes, keratitis, conjunctivitis, corneal eptithelial detachment, corneal ulcer, etc. It is preferably in the dosage form of eye drops. The concentration of gefarnate therein ranges, for example, from 0.1 to 3 % (w/v).
Patent PT-932871-E (PT)
Inventor: CHERNY JULIUS
IPC: G06F17/28
Filed: 1997-10-16
Abstract: Methods and apparatus for performing translation between different language are provided. The present invention includes a translation system that performs translation having increased accuracy by providing a three-dimensional topical dual-language database. The topical database includes a set of source-to-target language translations for each topic that the database is being used for. In one embodiment, a user first selects the topic of conversation, then words spoken into a telephone are translated and produced as synthesized voice signals from another telephone so that a near real-time conversation may be had between two people speaking different languages. An additional feature of the present invention is the addition of a computer terminal that displays the input and output phrases so that either user may edit the input phrases, or indicate that the translation was ambiguous and request a rephrasing of the material.
Patent PT-1042293-E (PT)
Title: Substituted pyridine and pyridazine compounds and their pharmaceutical use
Inventor: HWANG CHAN KOU
IPC: A61K31/4436
Filed: 1998-12-21
Abstract: Selected novel substituted pyridine and pyridazine compounds are effective for prophylaxis and treatment of diseases, such as TNF- alpha , IL-1 beta , IL-6 and/or IL-8 mediated diseases, and other maladies, such as cancer, pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving inflammation, cancer, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Patent PT-1070253-E (PT)
Title: Use of hroralpha receptors for screening substances useful for the treatment of atherosclerosis
Inventor: RASPE ERIC
IPC: G01N33/566
Filed: 1999-03-24
Abstract: The subject of the present invention is the use of the ROR receptors and/or of their response element or alternatively of a functional equivalent thereof for the screening of substances having antiatherosclerotic properties. The invention also relates to the methods of screening substances having antiatherosclerotic properties using the ROR receptors and/or their response elements. The invention also relates to the use of the methods of screening according to the present invention in order to characterize, justify and claim the mechanism of action of substances having antiatherosclerotic properties using the ROR receptors and/or their response elements as well as their effects on apo C-III.
Patent PT-1117454-E (PT)
Inventor: BRUNEL MARC
IPC: A61M5/32
Filed: 1999-09-30
Abstract: The invention relates to an injection device comprising a syringe body (1), which delimits a chamber which is designed to be filled with liquid, and a unit (25) for distributing the liquid, comprising an end piece for closing off the said chamber, which is extended by a base, which supports an injection needle which is protected by a protective cap (35), the said distribution unit being mobile axially between a closing-off position of the chamber, and a position for injection of the liquid. According to the invention, the unit (25) for distributing comprises an intermediate section (31) between the base and the closing-off end piece, and the syringe body (1) comprises a ring (6) which delimits two superimposed compartments (18, 19), which can each accommodate the said intermediate section. In addition, the protective cap (35) and this intermediate section (31) have complementary profiles (34, 38) in the form of a cam, which can permit generation of axial displacement of the unit (25) for distributing, towards its injection position, during rotation of the said protective cap.
Patent PT-1102670-E (PT)
Inventor: STEIL FREDERICK G
IPC: B29C45/28
Filed: 1999-12-17
Abstract: A valve for controlling the flow of fluent plastic material from an injection molding machine to a mold cavity. The valve includes an axially slidable valve pin that interacts with a material outlet to control flow through the valve selectively. The valve pin is actuated by an eccentric cam arrangement that positively drives the valve pin between positions where it is engaged with or disengaged from the material outlet. The cam acts on the valve pin only in an axial direction to avoid wear occasioned by side loads imposed on a valve pin.
Patent SG-1989-G (SG)
Title: Piperidine dione derivatives with a myocardium protecting and antiarrhythmic activity,process for their preparation and medicines,containing them
IPC: A61K31/44
Filed: 1989-01-11
Abstract: The present invention relates to derivatives of piperidinedione of formula:    <IMAGE>  (I)  in which R is alkyl or forms with N a possibly substituted morpholino or piperidino group, n=2 or 3, R1, R2, R3 and R4 represent H or lower alkyl; R3 and R4 taken together may represent (CH2)m where m=4 or 5 and R2 and R3 taken together may represent (CH2)p where p=3 or 4 and in this case R1 and R4=H, R5 is H or alkyl. It also relates to a process for manufacturing the product of formula (I) and to the drugs containing a product of formula (I).
Patent SG-32195-G (SG)
Title: Ventless hood for a deep fat fryer
Inventor: DUTT WILLIAM H
IPC: B29K75/00
Filed: 1995-02-22
Abstract: A belt (16) for use on an extended nip press for dewatering a fibrous web (17) is shown. The belt (16) includes a base fabric (22) having machine-direction (24) and cross-machine direction (26) yarns and takes the form of an endless loop. Either the machine-direction (24), or the cross-machine direction (26), yarns are spun yarns of staple fibers (34). The base fabric (22) is completely coated and impregnated with a polymeric resin, such as polyurethane, to render it impervious to liquids, especially lubricating oil. The inner surface (20) of the resulting belt slides over the arcuate pressure shoe component (14) of the extended nip press during its operation. The outer surface (19) of the belt is provided with grooves (30) separated by land areas (32) which together define channels for water pressed from the fibrous web (17) in the press nip. The land areas are anchored to the belt by means of staple fibers (34) from the spun yarns embedded in the coating (28) and thus resist delamination.
Patent SG-55587-G (SG)
Title: Connector housing
IPC: H01R13/422
Filed: 1987-06-29
Abstract: A connector housing (4) of rectangular box shape having a bottom part (5) and walls, for accepting an array of electrical terminal pins (2) which, arranged in a predetermined pattern, pass through corresponding apertures (9) in said bottom part, whereby the one and/or other protruding ends of said terminal pins permit further electrical connection, such as to a printed circuit board, whereby each aperture has a substantially rectangular cross-section, on two opposite sides of which spring elements (1,1 min ) are provided, the mutual spacing and arrangement of said spring elements in relation to terminal pin cross-section being such that, when inserted, a press-fit locking of the terminal pins is obtained.
Patent IE-33946-L (IE)
Title: 3-desoxo-19-nor-steroids
IPC: C07J11/00
Filed: 1970-01-19
Abstract: 1292201 3 - Unsubstituted - 7 - alkyl - androstane compounds ORGANON LABORATORIES Ltd 21 Jan 1970 [30 Jan 1969] 2895/70 Heading C2U Novel steroids of the formula wherein R 1 is C 2-4 alkyl; R 2 is an oxo group or (α-X) (#-Y) in which X is H or C 1-6 alkyl, alkenyl, alkadienyl, alkynyl or alkadiynyl and Y is free, esterified or etherified OH; R 3 is C 1-4 alkyl; and there is present a #<SP>4</SP>-, #<SP>5(10)</SP>- or #<SP>5</SP>-double bond, are prepared from the corresponding steroids containing in position-3 a cyclic or non-cyclic dithioketal group or a halogen atom or an aliphatic-, aromatic- or araliphatic-sulphonyloxy group, by reductive splitting off of the 3-substituent. Preferably, for preparation of #<SP>4</SP>- or #<SP>5(10)</SP>-compounds the 3- thioketals are treated with an alkali metal in liquid ammonia or a C 1-4 aliphatic primary amine, while for preparation of the #<SP>5</SP>-compounds the 3-halo or -sulphonyloxy steroids are treated in the same manner or with an alkali metal in an alcohol or with an alkali metal aluminium hydride. In the products the 17- substituents may be interconverted by standard procedures. Starting materials of the formula wherein R 4 is a cyclic or non-cyclic dithioketal group or (H) (Z) in which Z is a halogen atom or a sulphonyloxy group are prepared by thioketalization of the corresponding 3-keto steroids or esterification of the corresponding 3-ols. #<SP>5</SP> - 3#,17# - Dihydroxy - 7α,18 - dimethylestrene 17-benzoate is prepared by NaBH 4 reduction of #<SP>3</SP>'<SP>5</SP> - 3# - acetoxy - 17# - benzoyloxy- 7α,18 - dimethyl - estradiene, itself prepared by enol acetylation of the corresponding #<SP>4</SP>-3-one. The steroids of the invention are stated to possess progestative, anabolic, androgenic, estrogenio, ovulation-inhibiting and anti-fertilization properties. They may be made up into pharmaceutical compositions with suitable carriers.
[GB1292201A]
Patent IE-810305-L (IE)
Title: Modified microorganisms
IPC: A23K1/16
Filed: 1981-02-16
Abstract: A method for making a genetically modified microorganism wherein DNA material, particularly material comprising a gdh gene, is transferred from a donor microorganism to a recipient microorganism using a plasmid vector. The invention relates in particular to the use of multicopy plasmids and/or DNA fragments having at their ends target sites for SalI restriction enzymes. The method may involve a plurality of steps, transfer of DNA fragments into intermediate microorganisms and use of a plurality of plasmids. Genetically modified microorganisms and a process for the production of single cell protein using the genetically modified microorganisms are also claimed.
[EP0035831A2]
Patent IE-800395-L (IE)
Title: Non-aqueous electrochemical cell
IPC: H01M4/58
Filed: 1980-02-27
Abstract: A non-aqueous cell comprising an active metal anode, such as lithium, a liquid cathode-electrolyte comprising a solute dissolved in a solvent which is an oxyhalide of an element of Group V or Group VI of the Periodic Table and wherein elemental sulfur or a sulfur compound is incorporated into the cathode-electrolyte so as to substantially eliminate initial voltage delay of the cell during discharge.
[US4218523A]
Patent IE-39482-L (IE)
Title: Propanolamines
IPC: C07C239/00
Filed: 1974-02-28
Abstract: Racemic and optically active compounds of the formula R4 O-CH2-CHOH-CH2-NH-C-C 3BOND CH R5 wherein R1, R2, R3, R4 and R5 are hydrogen or various substituents, and their physiologically compatible acid addition salts, as well as the process for producing the compounds, therapeutic compositions and methods. The 1-aryloxy-2-hydroxy-3-alkynylamino-propanes have andrenolytic properties and blood-pressure reducing properties.
[US3925446A]
Patent IE-780440-L (IE)
Title: 3ß-IMINO=AZETIDIN-2-ONE DERIVATIVES.
IPC: C07D498/04
Filed: 1978-03-03
Abstract: 1-[ alpha -(Carboxy)-4-hydroxybenzyl]-3 beta -aminoazetidin-2-one esters are prepared by converting 2-acyl-3,3-dialkyl-7-oxo- alpha -[4-(benzyloxy)phenyl]-4-thia-2,6-diazabicyclo[3.2.0]-heptane-6-acetic acid esters with mercuric acetate in an aqueous organic solvent mixture, e.g., in aqueous methanol, to 7-oxo-3-phenyl- alpha -[4-(benzyloxy)phenyl]-4-oxa-2,6-diazabicyclo[3.2.0]hept-2-ene-1-acetic acid esters and the latter are reacted with PCl5 and pyridine to provide the monocyclic 1-[ alpha -(carboxy)-4-benzyloxybenzyl]-3 beta -( alpha -chlorobenzylideneamino)-4-chloroazetidin-2-one esters. Reduction of the dichloro azetidin-2-one with an organo tin hydride and azobisisobutyronitrile affords the deschloro, 1-[ alpha -(carboxy)-4-benzyloxybenzyl]-3 beta -benzylideneaminoazetidin-2-one ester. The latter is hydrolyzed and the 4-benzyloxy group is cleaved via catalytic hydrogenolysis to yield an ester of 1-[ alpha -(carboxy)-4-hydroxybenzyl]-3 beta -aminoazetidin-2-one. The 3 beta -amino ester is useful for the preparation of the antibiotic FR 1923 (nocardicin).
[US4127568A]
Patent IE-780643-L (IE)
Title: THERAPEUTIC APPLICATION OF d, 1-CARNITINE DERIVITIVES
IPC: A61K31/215
Filed: 1978-03-31
Abstract: Certain acylic methods of use of derivatives of the carnitine-d, 1 are proposed for the treatment of the myocardic anoxia, ischaemia, asynchronous syndromes and cardiac failure, as well in the animal as at the man. The acetyl-carnitine-d, 1 and its acceptable salts pharmaceutically, for example its hydrochlorate, represent a remarkable improvement in the treatment of the tiredness of the heart in the animal and the man, like in pathological situations characterized by disorders of heart rate. Others very effective derivatives of the carnitine are: the propionyl-carnitine-d, 1, the butyryl-carnitine-d, 1, the hydroxybutyryl-carnitine-d, 1, the hexanoyl-carnitine-d, 1, the octanoyl-carnitine-d, 1, the decanoyl-carnitine-d, 1, the palmitoyl-carnitine-d, 1, the stearoyl-carnitine-d, 1 and the acetoacetyl-carnitine-d, 1. [FR2388556A1]
Patent IE-39784-L (IE)
Title: Reinforcing elements
IPC: E04C5/01
Filed: 1974-03-26
Abstract: 1465271 Reinforcing with short wire strands BEKAERT SA NV 2 July 1974 [16 April 1973] 18322/73 Heading EIW Cast-material is reinforced with short wire strands, having a thickness between 0.1 and 1.0 mm and a length to thickness ratio in the range 50 to 200, by including within the mix reinforcing members comprising a plurality of single strands bonded together by a binder which binder is subsequently disintigrated so as to release the individual strands for final mixing. The members may be bundles of straight or helical wires or straight wires with bent ends. Alternatively the members may be arrays of straight or bent wires. The cross section of each wire may be circular or flattened and each wire may be coated with zinc, aluminium or organic material and have a roughened surface. The wires may be iron or steel alloyed with nickel or chromium. The cast material may be mortar, concrete, rubber or plastics. In hydraulic mineral cements the binder may be polyvinyl alcohol and the disintigration time varied by the incorporation of various amounts of non water soluble polyvinyl acetate. Other soluble binders may be: urea based resins, polyacrylate, albumins, gelatins, caseins or cellulose derivatives e.g. methylhydroxy- or carboxy-cellulose. Disintigration may be produced by other constituents of the mix than water and may be by normal or special additives or by heat i.e. by introducing steam. A process for producing the reinforcing members is illustrated in Fig. 4 where a number of wires are brought into close proximity in the same plane and passed through a bath 5 of liquid adhesive, excess adhesive removed by wipers 9, dried in chamber 6 and finally cut into short lengths by a cutter 7. In an alternative process scrap cables may be used producing bundles of large pitch helical strands.
[GB1465271A]
Patent IE-37747-L (IE)
Title: Apparatus for removing cheeses from cheese moulds
IPC: A01J25/12
Filed: 1973-06-06
Abstract: Apparatus for removing cheeses from rectangular, large cheese moulds lying side by side, in which moulds the bottom is composed of rectangular parts and one end of the mould has been constructed to constitute a door, through which the bottom parts of the mould and the cheese bolster resting thereupon can be extracted from the mould by the aid of a traction member, such as a rope or chain, the traction member being attached, on one hand, to one or several bottom parts and on the other hand to a winch constructed to be a carriage transportable from one cheese mould to another and having a tray for receiving one cheese at a time. In front of the cheese moulds there is a track for the winch carriage and that beside this track there is a conveyor, running parallel with same, for the cheeses, and the tray for receiving the cheeses on the winch carriage has been constructed as a lever turnable about its shaft and which upends the cheese together with the accompanying bottom part and drops them onto a table on the winch carriage or directly onto the cheese conveyor.
[US3899086A]
Patent FI-832539-L (FI)
Inventor: ENGSTROEM OLOF
IPC: G06T7/00
Filed: 1983-07-12
Abstract: PCT No. PCT/SE82/00390 Sec. 371 Date Jul. 22, 1983 Sec. 102(e) Date Jul. 22, 1983 PCT Filed Nov. 19, 1982 PCT Pub. No. WO83/01852 PCT Pub. Date May 26, 1983.The present invention relates to a method for comparison between a first optical signal ( PHI 1) and at least one other signal. The invention can for instance be used for image recognition. In this application it is a problem to be able to perform parallel processing of the content of an image. This problem among others is solved in connection with the invention by illuminating a MIS-structure (11; FIG. 1) with the first optical signal ( PHI 1), which creates an optically induced change in the surface potential of the MIS-structure and by influencing the surface potential also by said at least one other signal by illuminating the MIS-structure (11; FIG. 1) with a second optical signal ( PHI 2) or by applying the signal in the form of a voltage across the structure or by providing the structure with charge in the insulator or its interfaces or by a combination of these methods and by varying at least one of all signals as a function of time.
Patent FI-850366-L (FI)
Inventor: MELCHIOR JEAN
IPC: F02B37/16
Filed: 1985-01-28
Abstract: An internal combustion engine (1), supercharged by a turbocompressor (3), comprises a bypass conduit (11) in which is placed an auxiliary combustion chamber (14). The primary zone (13) of this chamber (14) receives fuel whose flow is determined by regulating means (20). These means (20) vary this flow in the same direction as a parameter which is a characteristic of the load of the engine (1), in particular the temperature of the gases measured in the exhaust of the engine (1) by a sensor (22).