baber/WOPTO huggingface dataset:
Patent DE-69629500-D1 (DE)
Inventor: BRYANT HENRY UHLMAN
IPC: C07D409/00
Filed: 1996-03-06
Granted: 2003-09-18
Abstract: The present invention provides a compound of formula I <CHEM> wherein R1 is H, OH, halo, OCO(C1-C6 alkyl), OCO(aryl), OSO2(C4-C6 alkyl), OCOO(C1-C6 alkyl), OCOO(aryl), OCONH(C1-C6 alkyl), or OCON(C1-C6 alkyl)2;     R2 is aryl, C1-C6 alkyl, C3-C6 cycloalkyl, or 4-cyclohexanol;     R3 is O(CH2)2 or O(CH2)3; R4 and R5 are optionally CO(CH2)2CH3, CO(CH2)3CH3, C1-C6 alkyl, or R4 and R5 combine to form, with the nitrogen to which they are attached, piperidine, morpholine, pyrrolidine, 3-methylpyrrolidine, 3,3-dimethylpyrrolidine, 3,4-dimethylpyrrolidine, azepine, or pipecoline;     R6 is  &rdurule&  C=CH2 , &rdurule& CH(C1-C5 alkyl),  &rdurule& CH(C2-C5 alkenyl),  &rdurule& C=CH(C1-C5 alkyl), &rdurule& CH(aryl),  &rdurule& C(OH)(C1-C5 alkyl),  &rdurule& C(OH) (C2-C5 alkenyl),  &rdurule& C(OH)aryl;  and pharmaceutically acceptable salts thereof. The present invention further provides pharmaceutical compositions containing compounds of formula I, optionally containing estrogen or progestin, and the use of such compounds alone, or in combination with estrogen or progestin, for alleviating the symptoms of post-menopausal syndrome, particularly osteoporosis, cardiovascular related pathological conditions, and estrogen-dependent cancer. As used herein, the term "progestin" includes compounds having progestational activity such as, for example, progesterone, norethylnodrel, nongestrel, megestrol acetate, norethindrone, and the like. The compounds of the present invention also are useful for inhibiting uterine fibroid disease and endometriosis in women and aortal smooth muscle cell proliferation, particularly restenosis, in humans.
Patent DE-69630882-D1 (DE)
Inventor: LOTHAMER JOHN
IPC: H01H1/40
Filed: 1996-03-22
Granted: 2004-01-08
Abstract: An interlock switch for electrically coupling opposing surfaces of a circuit card assembly, wherein each of the surfaces includes a contact pattern defining circuit and switch functions. The interlock switch comprises a pair of contacts which engage the contact patterns on the circuit card assembly to electrically couple the circuits located on the oppositely facing surfaces thereof and a switch body for housing the contacts. The switch body includes a slot for solder-free coupling the switch to an edge of the circuit card assembly. The slot enables the switch to selectively reciprocate among three switch positions on the edge of the circuit card assembly to provide either an open circuit or a closed circuit on the circuit card assembly in any one of three switch positions for each contact. A spring is housed within the switch body for biasing the switch from one of the three positions making it a momentary position. A pair of locking projections are provided for preventing the switch from being easily removed from the edge of the circuit card assembly.
Patent DE-69631555-D1 (DE)
Inventor: ZHONG PEI
IPC: A61B17/00
Filed: 1996-06-10
Granted: 2004-03-18
Abstract: The invention relates to a method for the comminution of concretions in vivo by controlled, concentrated cavitation energy. This method utilizes two shock wave pulses with a specified time delay and pressure relationship, with the first shock wave pulse being used to induce a transient cavitation bubble cluster near the target concretion, and the second shock wave pulse to control and force the collapse of the cavitation bubble cluster towards the target concretion with concentrated energy deposition, while avoiding injury to surrounding tissue caused by random collapse of the cavitation bubbles. This invention makes it possible to significantly enhance the fragmentation efficiency of the concretion using shock waves while reducing potential deleterious injury to surrounding tissue.
Patent DE-69637587-D1 (DE)
Inventor: FULLER FORREST H
IPC: C12P21/04
Filed: 1996-07-25
Granted: 2008-08-21
Abstract: The present invention provides chimeric receptors. The chimeric receptors comprise at least one region homologous to a region of a metabotropic glutamate receptor and at least one region homologous to a region of a calcium receptor. The invention also includes methods of preparing such chimeric receptors, and methods of using such receptors to identify and characterize compounds which modulate the activity of metabotropic glutamate receptors or calcium receptors. The invention also relates to compounds and methods for modulating metabotropic glutamate receptor activity and binding to metabotropic glutamate receptors. Modulation of metabotropic glutamate receptor activity can be used for different purposes such as treating neurological disorders and diseases, inducing an analgesic effect, cognition enhancement, and inducing a muscle-relaxant effect.
Patent DE-69700808-D1 (DE)
Inventor: SWINLEY GEORGE
IPC: F16C35/067
Filed: 1997-02-06
Granted: 1999-12-23
Abstract: A locking device for clamping a bearing (11) on to a shaft (10) comprises a collar (19) and a ring (13) fitted on the shaft. The collar (19) has an end wall (25) and an axial region (18) extending over an outer inclined contact surface (20) of the ring (13). The ring (13) and the collar end wall (25) have inner surfaces (9, 22) confronting the outer surface of the shaft (10), the surfaces (9, 22) being separated by sliding radial surfaces (50) of the collar (19) and the ring (13). Screw-threaded elements (21) in threaded bores (6) in the collar (19) can be tightened against the outer surface (20) of the ring (13) to cause contact zones (24, 26) of the inner surfaces (9, 22) to exert clamping force on the shaft (10) at diametrically opposed positions. The screw-threaded elements (21) and the bores (6) are in non-radial positions relative to the axis of rotation (P). The locking device may alternatively clamp to the inside of a tube (Figs 3, 4).
Patent DE-69707419-D1 (DE)
Inventor: ALOS RAPHAEL
IPC: H04W88/02
Filed: 1997-01-24
Granted: 2001-11-22
Abstract: A radio-telephone terminal includes connection structure which connects to a radio-telephone network, a telephone handset and a data adaptation circuit arranged to be connected to a data transmission apparatus. The adaptation circuit is integrated into the terminal and can include a microprocessor arranged to manage vocal telephone communications and the data passing through the adaptation circuit.
Patent DE-69722265-D1 (DE)
Inventor: OLSON AKE
IPC: B65D90/04
Filed: 1997-02-14
Granted: 2003-06-26
Abstract: PCT No. PCT/SE97/00250 Sec. 371 Date Sep. 15, 1998 Sec. 102(e) Date Sep. 15, 1998 PCT Filed Feb. 14, 1997 PCT Pub. No. WO97/34794 PCT Pub. Date Sep. 25, 1997A liner (1) intended as inner packing in a container (11) for holding a fluid, comprising an upper (2) and a lower (3) rectangular web of essentially the same length and width, which are made of a flexible material and which are joined (4) to each other along portions of their outer edges (8, 9, 34), and at least one sealable opening (5, 6) in one of the webs (3) for filling the liner (1) with said fluid and then emptying the liner of said fluid in the container (11). The novelty of the invention is that the liner integrally comprises a pair of flap members (41, 42) at one of the outer edges (33) between the webs (2, 3), that one flap member (41) has been folded over the upper web (2), that the corner portions (13) of the liner adjacent to the essentially unfolded flap member (42) have been folded towards the center over the upper web (2), and that the liner (1) has been folded symmetrically at least twice towards the symmetry line (7) over the upper web (2). The invention also relates to the use of the liner with a container.
Patent DE-69800500-D1 (DE)
Inventor: HAAVIK HAROLD K
IPC: F04D11/00
Filed: 1998-06-24
Granted: 2001-03-01
Abstract: A conically ported liquid ring pump has one or more port structures with cone angles in the range from 15 degrees to 75 degrees. These cone angles are substantially greater than previously used cone angles (most commonly about 8 degrees). The large cone angles of this invention give the fluid flowing between the cone and the rotor significant components of both radial and axial velocity. Large cone angles also allow the port structure(s) to be made axially shorter, which has a number of important advantages such as shortening the unsupported length of the rotor shaft. These attributes of the present pumps are helpful for such purposes as allowing the length-to-diameter ratios of the pumps to be economically increased. In addition, the pumps of this invention retain many of the desirable attributes of conically ported pumps. <IMAGE>
Patent DE-69809408-D1 (DE)
Inventor: DRAGO FILIPPO
IPC: A61P27/02
Filed: 1998-04-21
Granted: 2002-12-19
Abstract: The use of agents for blocking the synthesis of tyrosinase to prevent permanent pigmentation of the iris caused by melanin deposit induced by pharmacological treatments or by metabolic imbalance is described.
Patent DE-69809919-D1 (DE)
Inventor: SYMES KENNETH CHARLES
IPC: C11D3/37
Filed: 1998-06-30
Granted: 2003-01-16
Abstract: A dispersion of polymer particles in a liquid detergent concentrate is stabilized by covalent reaction of a stabilizer on to reactive groups on the polymer particles.
Patent DE-69824358-D1 (DE)
Inventor: GUERRA VALLESPI MARIBEL
IPC: A61P31/12
Filed: 1998-09-29
Granted: 2004-07-15
Abstract: The present invention relates a novel immunological effect of one peptide from Limulus anti-LPS factor protein. The immunological effect are, (1) Induce an antiviral state in both the Hep-2 and MDBK cell lines, (2) Supernatant from human mononuclear cells stimulated with peptide Limulus anti-LPS factor (LALF) is able to induce antiviral effect on Hep-2 cell line by mean of IFN- gamma  (3) LALF peptide is able to modulate the immune response in vitro and in vivo. The present invention can be used in therapeutic and/or prophylactic treatment regimens of humans and animals to enhance their immune responses, without stimulating the production of certain biochemical mediators (e.g., TNF- alpha , ) that can cause detrimental effects, such as fever and inflammation.
Patent DE-69826883-D1 (DE)
Inventor: PETERS DAN
IPC: C07D405/04
Filed: 1998-10-27
Granted: 2004-11-11
Abstract: Heteroaryl diazacycloalkane derivatives (I) are new. Heteroaryl diazacycloalkane derivatives of formula (I) and their enantiomers or mixtures, isotopes and salts are new. [Image] n : 1-3 m : 0-2; R : H, alkyl, cycloalkyl, cycloalkylalkyl or aralkyl; R 1>aminophenyl; nitrophenyl; hydroxyphenyl; alkoxyphenyl; monocyclic 5-6 membered heterocyclyl (optionally substituted by alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, cycloalkoxy, alkenoxy, alkynoxy, methylenedioxy, halo, CF 3, OCF 3, CN, amino, NO 2, COOR 3, CONR 2R 3, NHCO 2R 2and/or OCONR 2R 3); aryl (optionally substituted by alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, cycloalkoxy, alkenoxy, alkynoxy, methylenedioxy, halo, CF 3, OCF 3, CN, amino and/or NO 2); X-alkyl-Y-alkyl (optionally alkyl substituted by alkoxy or thioalkoxy); X-(alkyl) o-aryl (optionally substituted by alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, cycloalkoxy, alkenoxy, alkynoxy, methylene-dioxy, halo, CF 3, OCF 3, CN, amino and/or NO 2); X-(alkyl) o-Z (optionally substituted by alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, cycloalkoxy, alkenoxy, alkynoxy, methylenedioxy, halo, CF 3, OCF 3, CN, amino and/or NO 2), monocyclic 5-6 membered heterocyclyl (optionally substituted by alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, cycloalkoxy, alkenoxy, alkynoxy, methylenedioxy, halo, CF 3, OCF 3, CN, amino and/or NO 2) (sic), bicyclic heterocyclyl comprising a 5-6 membered monocyclic heterocyclyl fused to a benzene ring (optionally substituted by alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, alkoxy-alkoxy, cycloalkoxy, alkenoxy, alkynoxy, methylenedioxy, halo, CF 3, OCF 3, CN, amino, NO 2, aryl optionally substituted by alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, cycloalkoxy, alkenoxy, alkynoxy, methylenedioxy, halo, CF 3, OCF 3, CN, amine and/or NO 2) or monocyclic 5-6 membered heterocyclyl (optionally substituted by alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, cycloalkoxy, alkenoxy, alkynoxy, methylenedioxy, halo, CF 3, OCF 3, CN, amino and/or NO 2); X, Y : O, S or NH, N-alkyl or Se; o : 0 or 1 and Z : 5-6 membered monocyclic heterocyclyl. ACTIVITY : Analgesic; Neuroprotective; Nootropic; Tranquilizer; Antiinflammatory; Antiaddictive; Antismoking; Anticonvulsant; Neuroleptic; Antidepressant; Antiasthmatic; Antianginal; Antimigraine. The affinity of 1-(6-chloro-5-methoxy-3-pyridyl)-homopiperazine fumaric acid salt for nicotinic Ach receptors was investigated in a test for in vitroinhibition of 3H-cytisine binding. The compound exhibited and IC 50value of 0.0007 mu M. MECHANISM OF ACTION : Nicotinic acetyl choline receptor ligand.
Patent DE-69827989-D1 (DE)
Inventor: LORETTI MAURICE
IPC: A61J1/10
Filed: 1998-04-24
Granted: 2005-01-13
Abstract: The present invention relates to an impermeable flexible multicompartment bag for medical use for sterile solutions, and to a method for the preparation of such bags. Impermeable flexible multicompartment bags for medical use for sterile solutions for perfusions, consisting of two welded sheets of a composite material wherein the sheets forming the inner wall of the bag consist of a polypropylene and are bonded to an outer layer of a thermoplastic polymer by means of a polyolefin layer, characterized in that the sheets facing the contents of the bags which are made of a homophase copolymer of propylene are immediately welded in the intercompartment region and in the peripheral region such that the weld forming the intercompartment region can be ruptured with a force in the range of from 10 to 30 N while the weld in the peripheral region cannot be ruptured.
Patent DE-69829882-D1 (DE)
Inventor: LYNN M
IPC: B01J31/22
Filed: 1998-10-30
Granted: 2005-05-25
Abstract: Activation of ruthenium based catalyst compounds with acid to improve reaction rates and yields of olefin metathesis reactions, including ROMP, RCM, ADMET and cross-metathesis reactions is disclosed. The ruthenium catalyst compounds are ruthenium carbene complexes of the general formula AxLyXzRu=CHR' where x=0, 1 or 2, y=0, 1 or 2, and z=1 or 2 and where R' is hydrogen or a substituted or unsubstituted alkyl or aryl, L is any neutral electron donor, X is any anionic ligand, and A is a ligand having a covalent structure connecting a neutral electron donor and an anionic ligand. The use of acid with these catalysts allows for reactions with a wide range of olefins in a variety of solvents, including acid-initiated RIM processes and living ROMP reactions of water-soluble monomers in water.
Patent DE-69840332-D1 (DE)
Inventor: JIN HONG
IPC: C07K14/11
Filed: 1998-09-28
Granted: 2009-01-22
Abstract: The present invention relates to genetically engineered recombinant RS viruses and viral vectors which contain heterologous genes which for the use as vaccines. In accordance with the present invention, the recombinant RS viral vectors and viruses are engineered to contain heterologous genes, including genes of other viruses, pathogens, cellular genes, tumor antigens, or to encode combinations of genes from different strains of RSV.
Patent DE-69902130-D1 (DE)
Inventor: HAIMOVICH YOSEF
IPC: G08B13/12
Filed: 1999-08-31
Granted: 2002-08-22
Abstract: An electronic filament netting (10) characterized by a warp of a first plurality of wires (12) woven together with a weft of a second plurality of wires (14), wherein a random number of the warp and the weft wires (12, 14) are electrically connected to electronic monitoring apparatus (16) so as to create a random electrical connection which defines an initial electrical parameter, wherein a change in the initial electrical parameter is communicated to the electronic monitoring apparatus (16). <IMAGE>
Patent DE-69902368-D1 (DE)
Inventor: YVIN JEAN-CLAUDE
IPC: C07H3/00
Filed: 1999-04-13
Granted: 2002-09-05
Abstract: The invention concerns a method for preparing Laminaribiose comprising a step for glycoside binding between a donor and an acceptor of glycosyl. The invention is characterized in that the glycosyl donor is in pyranose form and corresponds to formula (II); the glycosyl acceptor is in furanose form and corresponds to formula (III); said binding step is performed in solution in an anhydrous organic solvent, at a temperature ranging between -80° C. and 40° C., for a time interval ranging between 1 minute and 8 hours, in the presence of a suitable promoter.</PTEXT>
Patent DE-69908304-D1 (DE)
Inventor: GUIVARC H POL-HENRI
IPC: A61K31/23
Filed: 1999-02-10
Granted: 2003-07-03
Abstract: Methods of treating inflammation of the gastrointestinal tract and/or systemic or local inflammation by administering a steroid anti-inflammatory or a non-steroid anti-inflammatory drug in conjunction with polyunsaturated fatty acids or their derivatives and optionally also a pharmacologically active antioxidant and compositions for practicing these methods are described.
Patent DE-69913614-D1 (DE)
Inventor: OHMORI MAKOTO
IPC: B60W10/10
Filed: 1999-07-20
Granted: 2004-01-29
Abstract: This invention relates to a shifting device for a synchromesh-type transmission. The subject to be solved by the present invention is to detect an accurate change of the input rotation at each area of the shifting operation, and to set the applying load to the shifting fork based on the change of input rotation. The shifting device for synchromesh-type transmission of the first invention is comprised of a detecting means for detecting a rotation change rate of an input shaft, a judging means for judging a balk point based on the rotation change rate of the input shaft detected by said detecting means, and a transmission controlling mechanism including a driving means electric-controlled for driving a shift actuator to shift the shift fork, the driving means controlling a drive current to the shift actuator when the balk point is detected bythe judging means. <IMAGE>
Patent DE-69916364-D1 (DE)
Inventor: HENMI TERUO
IPC: C01B39/00
Filed: 1999-06-11
Granted: 2004-05-19
Abstract: Artificial zeolite is made using coal ash, particularly fly ash, as the starting material, and quality of the artificial zeolite that is produced depends on the composition of the starting coal. Since the production of zeolite is impaired unless the starting materials, including silicic acid and aluminum, that are used in the synthesis of zeolite for catalysts, which is called synthetic zeolite, are of high purity, starting material of low purity cannot be employed. Therefore, the topic was the development of a method of producing inexpensive artificial zeolite of the desired quality employing unused resources, such as descended pyroclastic materials, incineration ash, glass waste, diatomaceous earth waste, aluminum dross, etc., as the starting materials. The present invention is a method whereby artificial zeolite is produced by heat treatment in the presence of water and alkali of an inorganic component comprising silicic acid or aluminum, or a mixture that has been obtained by adding glass, diatomaceous earth and aluminum dross, etc., to an inorganic component comprising silicic acid or aluminum. It is preferred that the alkali is sodium hydroxide or potassium hydroxide, the water and alkali are an aqueous alkali solution, the concentration of this aqueous alkali solution is 2 to 4 N, and heat treatment exceeds 100 DEG C.
Patent DE-69920746-D1 (DE)
Inventor: TEASLEY F
IPC: C08F4/44
Filed: 1999-10-13
Granted: 2004-11-04
Abstract: Certain alkylhaloaluminoxanes and other alkylhaloaluminum compounds, when used as cocatalysts for the polymerization of olefins with complexes of transition metals and neutral bidentate ligands give good yields of polyolefin when using less of the alkylhaloaluminoxane than other types of aluminum compounds.
Patent DE-69923407-D1 (DE)
Inventor: BLYTHE ROBERT
IPC: E01C13/06
Filed: 1999-05-26
Granted: 2005-03-03
Abstract: Construction materials suitable for use as, or in, a wearing course for children's play areas, games areas and like purposes, comprise an agglomerate of granules of a thermoplastic elastomer. The granules of the agglomerate are conveniently held together by means of a polyurethane or other binding agent or by being melded together. The thermoplastic elastomer is, for example, a block copolymer of the styrene type, for example a styrene-butadiene-styrene block copolymer. The granules of the thermoplastic elastomer are preferably angular granules or multi-facet granules.
Patent DE-69923840-D1 (DE)
Inventor: JUNG PROF DR
IPC: A61K48/00
Filed: 1999-09-09
Granted: 2005-03-31
Abstract: The invention provides a method for the transfer of RNA, especially mRNA, into cells and into organisms. This method is especially suited for applications in the field of gene therapy. The RNA is transferred in the form of a complex between at least one RNA and at least one cationic, especially polycationic, peptide or protein. Preferably protamine, poly-L-lysine and/or histone is used as cationic peptide or protein.
Patent DE-69928228-D1 (DE)
Inventor: PETERSEN LORENZO
IPC: A01N25/24
Filed: 1999-02-26
Granted: 2005-12-15
Abstract: A water-based, quick-drying, gel-type disinfectant composition comprising one of more anti-microbicidal ingredients, 0-30% of an alcohol, a thickening agent, an emulsifier, and water. The composition is especially relevant for use as a hand or skin disinfectant to be used in the food industry or in hospitals. The thickening agent is a crucial part of the composition and is typically selected from acrylic acid copolymers, methacrylic acid copolymers, sodium carboxycellulose, hydroxyethylcellulose, and hydroxypropylcellulose. A typical composition comprises 0.05-5.0% of a fatty alcohol-polyglycol ether as an emulsifier, 0.5-5.0% of glycerin, 0.01-2.0% of one of more additives including 0.05-1.0% of a basic compound, and substantially the balance of water.
Patent DE-69930677-D1 (DE)
Inventor: FAROOQ FAREEDUDDIN
IPC: C08F265/06
Filed: 1999-10-25
Granted: 2006-05-18
Abstract: Acrylic compositions which can be processed into thermoformable acrylic sheet material with variegated non-homogeneous granite appearance are disclosed. The acrylic compositions comprise a matrix of polymethyl methacrylate having dispersed within it particles of a thermoplastic such as polymethyl methacrylate and one or more comonomers wherein the thermoplastic is in the shape of thin wafers 0.05 to 9.53 mm thick, 0.18 to 12.8 wide and 0.18 to 7.62 mm long.
Patent DE-69931002-D1 (DE)
Inventor: CALLENS RONY
IPC: B27L11/00
Filed: 1999-09-24
Granted: 2006-06-01
Abstract: The machine has a rotating drum (18) which is rotated around an axis (20) by a rotational control system (22). the drum is fitted with interchangeable cutters (44), arranged parallel to the axis (20). The machine also includes a fixed block feed channel (34) , whose first end is near to the exterior of the basket and whose second end in the drum (18) in front of the cutters (44). A controlled endless screw (36,38) advances the blocks in the channel (34) to the cutters at a controlled constant speed. The speed control system can vary the speed of advancement of the blocks to be cut.