baber/WOPTO huggingface dataset:
Patent CA-3074303-A1 (CA)
Inventor: LI ZHEN
IPC: C12N15/113
Filed: 2018-09-10
Abstract: The present disclosure relates to RNAi agents, e.g., double stranded RNAi agents, capable of inhibiting Apolipoprotein C-III (also called APOC3, apoC-III, APOC-III, and APO C- III) gene expression, and compositions that include APOC3 RNAi agents. The APOC3 RNAi agents disclosed herein may be conjugated to targeting ligands. including ligands that include N -acetylgalactosamine, to facilitate the delivery to cells, including to hepatocytes. Pharmaceutical compositions that include one or more APOC3 RNAi agents, optionally with one or more additional therapeutics, are also described. Delivery of the APOC3 RNAi agents in vivo provides for inhibition of APOC3 gene expression, and can result in lower triglycerides and or cholesterol levels in the subject. The APOC3 RNAi agents can be used in methods of treatment of APOC3-related diseases and disorders, including hypertriglyceridemia, cardiovascular disease, and other metabolic-related disorders and diseases.
Patent CA-3079199-A1 (CA)
Title: Microfluidic cassette for synthesising a radiotracer and method for synthesising a radio-tracer with such a cassette
Inventor: HOURTANE VIRGINIE
IPC: B01J19/00
Filed: 2018-10-12
Abstract: The present application concerns a microfluidic cassette for synthesising a radiotracer comprising a microfluidic circuit in a support card that comprises at least one intake for supply by a vial (Pf), at least one isotope port (IP), at least one reaction chamber (R1, R2, R3, R4), at least one mixing chamber (M1, M2, M3, M4), at least one formulation chamber (FC), and at least one connection for a syringe (SP), linked together by capillaries. The invention also relates to a method for synthesising a radiotracer in such a cassette.
Patent CA-3079571-A1 (CA)
Title: Nanoparticules plasmoniques utilisees en tant que pixels et commutateurs d'une duree inferieure a la microseconde
Inventor: FONTANA JAKE
IPC: G02F1/00
Filed: 2018-10-17
Abstract: L'application d'un champ électrique à des nanotiges peut commander leur alignement, fournissant ainsi des techniques de commutation ultra-rapide et des modulateurs optiques, par exemple celles qui pourraient servir en tant qu'indicateurs d'affichage.
Patent CA-3080091-A1 (CA)
Title: Derive de pyrrolidine amorphe utilise en tant qu'agoniste de ppar et son procede de preparation
Inventor: YUAN ZHILIANG
IPC: A61P1/16
Filed: 2018-12-20
Abstract: La présente invention concerne un dérivé de pyrrolidine amorphe utilisé en tant qu'agoniste de PPAR et un procédé de préparation de celui-ci.
Patent CA-3082184-A1 (CA)
Inventor: CHAN YIUMO
IPC: C07C279/14
Filed: 2018-12-03
Abstract: La présente invention concerne des analogues de promédicaments à base de créatine et leurs compositions, utiles pour le traitement des déficiences en créatine.
Patent CA-3082463-A1 (CA)
Title: Fabric and method of manufacturing
Inventor: AL-JUMAILY AHMED
IPC: C08F251/02
Filed: 2018-11-13
Abstract: A moisture exchange fabric is disclosed the fabric comprising: a substrate fabric; a polymer having lower critical solution temperature (LCST) of between 25°C and 39°C bonded to the substrate fabric; and a filament sewed into the substrate fabric. Also disclosed is a humidifying apparatus using the moisture exchange fabric.
Patent CA-3083559-A1 (CA)
Inventor: CHAMBERS LARRY DELYNN
IPC: E21B34/06
Filed: 2018-02-02
Abstract: A drill string steering system includes a motor and a rotary valve body disposed in a tool body. The motor includes a motor shaft coupled to the motor and extending within a central bore of the tool body. The motor shaft has a downhole engagement portion that includes a first splined surface. The rotary valve body includes a disk-shaped component and a valve shaft coupled to the disk-shaped component and extending uphole of the disk-shaped component. The valve shaft includes a second splined surface engageable with the first splined surface for rotation of the motor shaft to be imparted to the rotary valve body.
Patent CA-3083669-A1 (CA)
Title: Folding tonneau cover apparatus
Inventor: SCHMEICHEL CHARLES M
IPC: B60P7/02
Filed: 2016-11-01
Abstract: A folding tonneau cover apparatus including a cover assembly and a support frame assembly. The cover assembly having a plurality of rigid panels interconnected in series by flexible hinges preferably made from a laminated woven fabric material. The rigid panels are preferably stiffened by elongated support members secured to the undersides of the respective panels and the top surfaces of portions of the rigid panels are preferably downwardly concave. The cover assembly is secured to the support frame assembly to cover a cargo box of a pickup truck by a plurality of locking members when the support frame assembly is secured to sidewalls of the cargo box. Methods of making a tonneau cover apparatus and methods of folding and unfolding the cover assembly are also disclosed.
Patent CA-3085065-A1 (CA)
Title: Formulations providing high nicotine concentrations
Inventor: NIELSEN BRUNO PROVSTGAARD
IPC: A61K9/00
Filed: 2018-12-07
Abstract: The invention relates to an oral nicotine formulation for use in the alleviation of nicotine craving, the formulation comprising a content of nicotine and a content of a pH regulating agent, wherein the formulation provides a peak saliva concentration of nicotine of more than 0.3 mg/mL and a peak saliva pH of more than 7.5 during the first 120 seconds upon oral administration.
Patent CA-3085671-A1 (CA)
Inventor: ECKHARDT MATTHIAS
IPC: C07C253/30
Filed: 2018-12-17
Abstract: The invention relates to a process for the manufacture of the crystalline compound according to formula (I) comprising the steps (a) deacetylating the final intermediate (FT), (b) forming the crystalline compound according to formula (I) by reacting the deacetylated final intermediate of step (a) with L-proline and water and isolating the final reaction product, processes for manufacturing intermediates thereof, process intermediates and their uses in the processes according to the present invention.
Patent CA-3089541-A1 (CA)
Inventor: ZULETA DAVID
IPC: G16H20/13
Filed: 2019-01-26
Abstract: L'invention concerne un système de distribution de pilules qui comprend un distributeur de pilules, qui comprend un corps, un orifice de distribution dans le corps pour distribuer un médicament à partir du corps, et un processeur informatique supporté par le corps. Dans un mode de réalisation, le système de distribution de pilules comprend une plateforme de système de distribution et un distributeur de pilules conçu pour communiquer avec la plateforme de système de distribution. La plateforme de système de distribution comprend un module administrateur ayant une base de données centrale et un portail administrateur configuré pour un accès par un administrateur système. Un dispositif de clé de distributeur de pilules comprend un corps logeant un processeur, une mémoire et un élément de communication, le processeur, la mémoire et l'élément de communication étant configurés pour communiquer une clé numérique à un distributeur de pilules.
Patent CA-3091291-A1 (CA)
Title: Downhole well integrity reconstruction in the hydrocarbon industry
Inventor: ALJUBRAN MOHAMMAD
IPC: E21B41/00
Filed: 2019-02-11
Abstract: The present disclosure describes methods and systems for downhole well integrity reconstruction in a hydrocarbon reservoir. One method for downhole well integrity reconstruction in a hydrocarbon reservoir includes: positioning a laser head (150) at a first subterranean location, wherein the laser head is attached to a tubular inside of a wellbore; directing, by the laser head, a laser beam (242) towards a leak on the wellbore; and sealing the leak using the laser beam.
Patent CA-3092600-A1 (CA)
Inventor: XU HENG
IPC: A61K31/436
Filed: 2019-01-30
Abstract: The present invention relates to a benzamide compound and a preparation method, use and pharmaceutical composition thereof. The benzamide compound represented by formula (I) is a STAT3 inhibitor, and can be used to prevent and/or treat a disease related to STAT3 activity, such as a tumor, autoimmune disease, renal disease, cardiovascular disease, inflammation, metabolic/endocrine dysfunction, and neurological disease.
Patent CA-3092784-A1 (CA)
Inventor: MOHR DURDEZ THEOPHILE
IPC: A61B5/361
Filed: 2019-03-26
Abstract: A device for detecting heart rhythm disorders comprises a memory (10) designed to receive cardiac electrogram data and to store data defining a first classification model for detecting heart rhythm disorders and a second classification model for detecting heart rhythm disorders, a classifier (6) designed to analyse cardiac electrogram data based on a classification model, and to return a classification value, and a driver (8) design to store cardiac electrogram data in the memory and analyse them with the classifier, and to return alert data when the analysis by the classifier returns a classification value associated with a heart rhythm disorder.
Patent CA-3096402-A1 (CA)
Title: Vehicle rail mounting device
Inventor: SCHONSTEIN PETER
IPC: E01B9/68
Filed: 2019-04-11
Abstract: A vehicle rail mounting device (10) Is provided for mounting a vehicle rail (12) on a support structure (14). The device Includes a bottom piece (16), an elastomeric bearing element (18) to be supported on the bottom piece, top cover elements (22) having elastomeric element retainers (54), a top piece (20), and rail connectors (82). The elastomeric element retainers are provided to retain the elastomeric element in place while the elastomeric element is adapted to retain the top piece, and hence the rail connectors, and therefore also the rail, in place. The top cover elements can be connected to the to the bottom and to the support structure to keep the whole device in place.
Patent CA-3096799-A1 (CA)
Title: Methods and apparatus to control heating based on monitoring feedback of temperature sensors
Inventor: ANDERSON DYLAN
IPC: G05D23/19
Filed: 2020-10-22
Abstract: Methods and apparatus to control heating based on monitoring feedback of temperature sensors are disclosed. An example heating apparatus includes: a heater configured to apply heat energy to an object; and control circuitry configured to: control the heater based on a target temperature to which the object is to be heated; in response to determining that a first measured temperature sample associated with a first temperature sensor is greater than a first reference temperature, updating a first temperature range and the first reference temperature based on the first measured temperature sample; and in response to determining that a second measured temperature sample associated with the first temperature sensor is not within the first temperature range, reduce the priority of the first temperature sensor for control of applying the heat energy to the object.
Patent CA-3099552-A1 (CA)
Title: Analysis and presentation of agricultural data
Inventor: BONES TAVIS
IPC: G06Q50/02
Filed: 2019-05-08
Abstract: A computer-implemented method is disclosed. The method comprises causing display of a first map of one or more agricultural fields, the first map indicating a first type of farming data; receiving cost data corresponding to a second type of farming data; receiving revenue data; performing an RoI analysis for the one or more agricultural fields having a plurality of components, including cost data associated with a third type of farming data, the revenue data, and corresponding RoI data; causing display of a second map of the one or more agricultural fields concurrently with the first map, the second map indicating a first component of the RoI analysis; receiving a selection of points from the second map, the selection corresponding to a boundary of a region within the one or more agricultural fields; causing display of a report indicating the first component of the RoI analysis specific to the region.
Patent CA-3102306-A1 (CA)
Title: Mitigation of external exposure of energy delivery systems
Inventor: MYLREA MICHAEL E
IPC: H04L12/26
Filed: 2020-12-10
Abstract: MITIGATION OF EXTERNAL EXPOSURE OF ENERGY DELIVERY SYSTEMS ABSTRACT OF THE DISCLOSURE      Method include receiving banner information from one or more queries of a network connecting a set of devices, wherein the banner information of one or more of the devices includes common vulnerability and exposure identifiers (CVEs) and the banner infomiation of one or more of the devices does not include a CVE, identifying the devices based on the banner information including classifying devices without known CVEs by a device type, determining vulnerability scores for the devices with known CVEs based on retrieved CVE information, and determining vulnerability scores for the devices without CVEs based on a series of exploitability and impact parameter estimates associated with the device type classifications. Some methods include estimating a cyberattack vulnerability risk for the devices using the determined vulnerability scores.   Date Recue/Date Received 2020-12-10
Patent CA-3106533-A1 (CA)
Inventor: FLORY ANNY L
IPC: C08L23/04
Filed: 2019-06-27
Abstract: The present disclosure provides a coated conductor. The coated conductor includes a conductor and an outermost coating on the conductor. The coating includes (A) an ethylene-based polymer having an I21/I2 ratio from 20 to 50; and (B) a propylene/ethylene copolymer having a Mw/Mn from 2.0 to 3.5. The coating has a surface roughness from 20 µ-inch to 100 µ-inch.
Patent CA-3109278-A1 (CA)
Title: Delivering tap with internal valve with flexible edges and multiple seals
Inventor: NINI DIEGO
IPC: B67D3/04
Filed: 2019-07-25
Abstract: A delivering tap (1) is described, for delivering liquids from a container comprising a main body (3) with a connecting element (3.20) comprising fitting means (3.1) with the container, and a supporting body (3.21) adapted to be closed by a plug (11) comprising an upper plug (2), an internal sealing valve (5) and a stem (4), the supporting body (3.21) comprising an outlet opening (3.2), an internal sealing surface (3.6) and external guiding means (3.7); the upper plug (2) comprising the internal guiding means (2.2), first fastening means (2.5) and upper sealing means; the stem (4) comprising second fastening means (4.4) to the first fastening means (2.5) of the upper plug (2), stem sealing means (4.5), and the lower sealing means (4.11); the internal valve (5) comprising second valve sealing means (5.5, 5.6) and the first valve sealing means (5.2).
Patent CA-3109606-A1 (CA)
Title: Low sulfur fuel oil blends for paraffinic resid stability and associated methods
Inventor: WOODCHICK MATTHEW T
IPC: C10L1/04
Filed: 2021-02-19
Abstract: Low sulfur fuel oil blend compositions and methods of making such blend compositions to increase the stability and compatibility of LSFO blends having paraffinic resids that are blended with distillates and/or cracked stocks of higher asphaltenes and/or aromatics content. In one or more embodiments, distillates and/or cracked stocks that incrementally reduce the initial aromaticity of the distillate or cracked stock with the highest aromaticity are sequentially blended prior to resid addition. Such incremental reduction and sequential blending have been found to provide a resulting low sulfur fuel oil blend that is both compatible and stable.
Patent CA-3111148-A1 (CA)
Inventor: ESKRIDGE HORACE ROBERT
IPC: A61G7/002
Filed: 2019-09-05
Abstract: A rotating and articulating bed has a fixed bed frame, a rotation assembly mounted on the fixed bed frame, a pivot assembly mounted on the rotation assembly and an articulating bed frame mounted on the pivot assembly. The articulating bed frame contains a plurality of pivotally connected distinct portions. The rotation assembly rotates the pivot assembly and the articulating bed frame with respect to the fixed bed frame on a plurality of discrete wheel bearings around a vertical axis passing through the rotating and articulating bed. The articulating bed frame articulates the distinct portions and the pivot assembly tilts the articulating bed frame with respect to a horizontal plane that is perpendicular to the vertical axis independent of rotation by the rotation assembly and articulation by the articulating bed frame.
Patent CA-3111652-A1 (CA)
Title: Transporter having lowerable bed
Inventor: ROSKOPF DENNIS
IPC: B60P1/43
Filed: 2021-03-09
Abstract: A transporter includes a frame supported on wheels, a cab mounted on a front portion of the frame, and a bed mounted on the rear portion of the frame. The bed includes deck plates and supports mounting the deck plates on the frame. At least a rear end portion of the bed is raiseable and lowerable relative to the frame. The bed is sufficiently lightweight that the transporter has a hauling capacity of at least 10,000 lbs.  and a fully loaded gross vehicle weight of no more than 26,000 lbs. At least portions of the bed may be made from high strength steel (HSS) such as ASTM A1011/1011M  steel having a grade of 80 or higher. A ramp, which may also be made of HSS, may be attachable to the rear of the bed and may have longitudinally extending supports and slats that may be arranged in a herringbone pattern.
Patent CA-3112626-A1 (CA)
Inventor: MEREE CAITLIN E
IPC: C08L9/06
Filed: 2019-09-13
Abstract: The present disclosure provides a polymeric membrane. The polymeric membrane includes a first thermoplastic elastomer layer that comprises a styrenic thermoplastic. The thermoplastic elastomer layer has a foam structure. The polymeric membrane can further include an optional second thermoplastic elastomer layer in contact with the first polyolefin layer.
Patent CA-3115663-A1 (CA)
Inventor: JOHNSON STEVEN
IPC: B60R11/04
Filed: 2021-04-21
Abstract: A camera system for a trailer that cooperates with a tarping system of the trailer to capture images during loading and unloading. The camera transmits the images to a display. A driver may watch the display to monitor loading and unloading.  The camera system maintains a camera of the camera system positioned to capture images of an interior of the trailer regardless of the operation of the tarping system.  The camera system generally includes an arm member, a pivot structure connected to the arm member, a camera connected to the arm member, and a weight connected to the arm member. Responsive to a force of gravity the camera remains oriented upward to capture images of the interior of the trailer during loading and unloading.
Patent CA-3116986-A1 (CA)
Inventor: BABICH KEVIN J
IPC: H04B10/25
Filed: 2018-10-24
Abstract: A communication system transmits a data signal between a transmitter and a receiver. A service provider operates the communication system for a client. When the data signal is received at the receiver, the data signal is decoded and the service provider decides whether the decoded data signal is accurate or whether the decoded data signal should be rejected. The service provider transmits the decoded data signal and its determination as to its accuracy to the client. Metadata including information about the transmission of the data signal is also provided to the client so that the client can make its own determination regarding whether to accept or reject the decoded data signal.
Patent CA-3117724-A1 (CA)
Inventor: GOLDSMITH PAUL S
IPC: B24D3/28
Filed: 2019-12-20
Abstract: The present invention relates generally to coated abrasive articles, such as coated abrasive film belts having improved strength and durability, as well as methods of making and using said coated abrasive articles.
Patent CA-3118008-A1 (CA)
Inventor: FAN JUN
IPC: B65D43/02
Filed: 2019-10-28
Abstract: Disclosed is a snap-fitting structure of a paper and plastic container, the paper and plastic container comprising a container (10) and a cover body (20), the container (10) comprising a body (11) and a clamping portion (12), the clamping portion (12) comprising a connecting portion (121) and a clamp ring (122), wherein in a cross section along a central axis of the body (11), the included angle between the contour line of the connecting portion (121) and the central axis of the body (11) is an acute angle, the contour line of the clamp ring (122) is parallel to the central axis of the body (11), the cover body (20) comprises a cover bottom (21), a cover wall (22) and a flange (23), the outer diameter of the clamp ring (122) is equivalent to the inner diameter of the cover wall (22), the flange (23) and the cover bottom (21) are arranged at an interval, and the clamp ring (122) is clamped between the flange (23) and the cover bottom (21) when the cover body (20) covers the container (10). According to the snap-fitting structure of the paper and plastic container, when the clamp ring (122) is beyond the flange (23), the clamp ring (122) restores to the original state or is still in a deformed state to abut against the cover wall (22), and is clamped between the cover bottom (21) and the flange (23), such that the container (10) and the cover body (20) are fitted in a covering manner and are not disengaged without an external force.
Patent CA-3118175-A1 (CA)
Inventor: BARBASH OLENA
IPC: A61K45/06
Filed: 2019-11-06
Abstract: La présente invention concerne une combinaison d'un inhibiteur de la protéine arginine méthyltransférase 5 (PRMT5) et d'un inhibiteur du lymphome des cellules B (BCL-2) et l'utilisation de cette combinaison dans le traitement du cancer. Dans des exemples spécifiques de l'invention, l'inhibiteur de PRMT5 peut être un composé de formule (I).
Patent CA-3119259-A1 (CA)
Title: Regenerative abscopal effects
Inventor: O'HEERON PETE
IPC: C12N5/077
Filed: 2019-11-08
Abstract: Embodiments of the disclosure encompass methods and compositions using fibroblasts for stimulating regeneration in a first tissue site in an individual, comprising the step of administering at least one regenerative composition to a second tissue site, wherein the second tissue site comprises the same tissue type as the first tissue site in the individual. The first and second sites are at different locations in the individual, in particular embodiments. Particular embodiments comprise administering one or more compositions to an individual at a different anatomical site than the site that is in need, such as a joint.
Patent CA-3119755-A1 (CA)
Title: Eutectic formulations of amitriptyline hydrochloride and mannitol
Inventor: NEBULONI MARINO
IPC: A61K47/10
Filed: 2014-03-14
Abstract: Both sublingual and oral formulations have issues with the stability of Active Pharmaceutical Ingredients, thus, a method or composition that increases the stability of Amitriptyline HC1 in a formulation would be useful. The present invention relates to pharmaceutical compositions and methods of manufacturing the same by mixing, milling or spray drying, in which the pharmaceutical composition comprises a eutectic of Amitriptyline HC1 and P-mannitol. The eutectic comprises 75%±2% Amitriptyline HC1 and 25%±2% P-mannitol by weight. The pharmaceutical compositions further comprise a basifying agent. Eutectic compositions often have higher stability and/or dissolution rates than their non-eutectic counterparts and the present invention addresses this unmet need to stabilize Amitriptyline HC1.
Patent CA-3120251-A1 (CA)
Title: Enhanced perovskite materials for photovoltaic devices
Inventor: IRWIN MICHAEL D
IPC: H01L31/18
Filed: 2019-11-08
Abstract: A perovskite material that has a perovskite crystal lattice having a formula of CxMyXz, where x, y, and z, are real numbers, and 1, 4-diammonium butane cation cations disposed within or at a surface of the perovskite crystal lattice. C comprises one or more cations selected from the group consisting of Group 1 metals, Group 2 metals, ammonium, formamidinium, guanidinium, and ethene tetramine. M comprises one or more metals each selected from the group consisting of Be, Mg, Ca, Sr, Ba, Fe, Cd, Co, Ni, Cu, Ag, Au, Hg, Sn, Ge, Ga, Pb, In, Tl, Sb, Bi, Ti, Zn, Cd, Hg, and Zr and combinations thereof. X comprises one or more anions each selected from the group consisting of halides, sulfides, selenides, and combinations thereof.