baber/WOPTO huggingface dataset:
Patent NZ-501181-A (NZ)
Title: Use of inhibitors selected from cAMP antagonists, hammerhead ribozymes, sequence specific antisense oligonucleotides and anchoring disruption peptides for treating immunosuppressive diseases
Inventor: AANDAHL EINAR MARTIN
IPC: A61K38/00
Filed: 1998-04-29
Abstract: Inhibitors that abolish the function of cAMP dependent protein kinase (PKA) type Iá (RIá2C2) selected from cAMP antagonists, sequence specific antagonists, hammerhead ribozymes, sequence specific antisense oligonucleotides and anchoring disruption peptides may be used to treat immunosuppressive diseases such as AIDS, HIV infection or CVI. Preferred cAMP antagonists include Rp-8-Br-cAMPS, Rp-8-Br-monobutyryl-cAMPS, Rp-monobutyryl-cAMPS, Rp-8-CI-cAMPs, Rp-8-(4 chlorophenyIthiol)-cAMPs and Rp-8-piperidino-cAMPS. Fig.1A shows levels of endogenous cAMP in peripheral blood CD3+ T cells from normal healthy blood donors (left, n=10) and HIV-infected patients (right, n=9).  Levels of endogenous cAMP were examined in peripheral blood CD3+ T cells from normal healthy blood donors (left, n=10) and HIV-infected patients (right, n=9).  CM+ T cells were isolated at 4oC by negative selection.  Median values (horizontal line) and single patient data (open circles) are shown. * denotes p<0.05.
Patent NZ-502491-A (NZ)
Title: Structure based modelling method for preparing a herbicide which inhibits acetohydroxy acid synthase (AHAS) activity
Inventor: KAKEFUDA GENICHI
IPC: A01H5/00
Filed: 1996-04-19
Abstract: A structure based modeling method for the preparation of a first herbicide, which inhibits AHAS (acetohydroxy acid synthase) activity where the method is: a) aligning a target AHAS protein on pyruvate oxidase template or an AHAS modeling functional equivalent thereof selected from transketolases, carboligases and pyruvate decarboxylase to derive the three dimensional structure of the target AHAS protein b) modeling a second herbicide having AHAS inhibiting activity into said three dimensional structure to derive the location, structure, or a combination thereof of a herbicide binding pocket in the target AHAS protein; c) designing a non-peptidic first herbicide, which will interact with an AHAS activity inhibiting effective portion of the binding pocket, wherein said first herbicide inhibits the AHAS activity sufficiently to destroy the viability of a cell which requires AHAS activity for viability. The AHAS protein can be derived from Arabidopsis thaliana. Divided from 500281
Patent NZ-504710-A (NZ)
Title: Chromatography assay for the detection of analytes in blood
Inventor: YOSHIMURA TORU
IPC: G01N33/576
Filed: 1998-12-29
Abstract: A chromatography assay device for detecting the presence of an analyte in a blood sample.  The device comprises a chromatography carrier which defines a path for fluid flow and supports capillary flow, an application site for the blood sample in fluid contact with the chromatography carrier, a detection site on the chromatography carrier possessing a non-diffusively bound trapping substance, a diffusively bound labeled substance, a diffusively bound polycation for separating plasma or serum from the blood sample upstream of the detection site, and a diffusively bound polyanion for neutralising the polycation downstream of the polycation and upstream of the detection site.
Patent NZ-505127-A (NZ)
Title: Oral pharmaceutical extended release dosage form of proton pump inhibitor
Inventor: KAREHILL PER-GUNNAR
IPC: A61P1/04
Filed: 1998-12-17
Abstract: An extended-release dosage form of an acid susceptible 'H+, K+ ATPase inhibitor' compound of formula (I), wherein said dosage form comprises a core material of a hydrophilic or hydrophobic matrix containing said inhibitor drug, a surrounding separating layer, and an enteric coating layer. Het1-X-SO-Het­2       (I) Wherein Het1 and Het2 are defined heterocyclic compounds, and X is either  -CHR- or a defined heterocyclic compound.
Patent NZ-506189-A (NZ)
Title: Crash barrier and rod locked barrier elements
Inventor: ENGLUND GUNNAR
IPC: E01F15/08
Filed: 1999-02-05
Abstract: A crash barrier to be arranged in the middle of a dual carriageway and composed of a plurality of elongate barrier elements (1) preferably made of concrete.  The elements (1) are arranged successively with the short sides of the respective barrier elements neighbouring each other.  Neighbouring barrier elements (1, 1') are interconnected by means of articulated connections (5, 6, 5', 6', 8), which prevent lateral displacement of the interconnected short sides relative to each other, but permit force-absorbing deformation of the crash barrier by pivoting of the barrier elements relative to each other in case a vehicle collides with the crash barrier.  Each barrier element (1) has at least two projecting connecting elements (5, 6) from each short side, which are connected with corresponding connecting elements (5', 6') of a neighbouring barrier element (1') by means of a rod (8), which is passed through holes (7) in each connecting element. A sleeve (9) cast into the barrier element (1) permits limited displacement of the connecting elements (5, 6) between two end positions.
Patent NZ-509408-A (NZ)
Title: Quick-cook dehydrated vegetables having a moisture content of 12% or less
Inventor: LEWIS VICTOR MARCUS
IPC: A23B7/022
Filed: 1999-07-15
Abstract: Quick-cooked dehydrated vegetables having moisture content of about 12 % or less have been compressed, but maintain a substantially intact cellular structure. On being placed in water at a temperature of 90 DEG C to 100 DEG C, the vegetables are capable of rehydration substantially to their original fresh dimensions, and are of edible tenderness and texture instantly or within five minutes. Also, processes for the production of a dehydrated, rapidly rehydrating vegetable product by compression of a partially dehydrated vegetable product.
Patent NZ-511112-A (NZ)
Title: Lipsome-entrapped topoisomerase inhibitors
Inventor: SLATER JAMES LLOYD
IPC: A61K31/496
Filed: 1999-10-15
Abstract: A composition for treating a tumor in a subject, comprising liposomes composed of a vesicle-forming lipid and between 1-20 mole percent of a vesicle-forming lipid derivatised with a hydrophilic polymer. The liposomes being formed under conditions that distribute the polymer on both sides of the liposomes bilayer membranes. Entrapped in the liposomes, is a topoisomerase inhibitor at a concentration of at least 0.10 mole drug per mole lipid. Wherein the liposomes have an inside/outside ion gradient sufficient to retain the topoisomerase inhibitor within the liposomes at the specified concentration prior to in vivo administration, and wherein the liposome-entrapped topoisomerase inhibitor has a longer blood circulation lifetime than the topoisomerase inhibitor in free form.
Patent NZ-512358-A (NZ)
Title: A device comprisng a porous central body a plunger and sealing elements for facilitating the implantation of biological material
Inventor: VALDES GONZALEZ RAFAEL
IPC: A61F2/06
Filed: 1999-12-14
Abstract: A device for implanting biological material comprises a central porous tubular body having means of closing at corresponding ends of the porous body, a plunger of a diameter and length that enables insertion inside the porous body and closing elements made with a material that when interacting with tissues of a living organism favours the formation of fibrocollagen over the surface of the porous body to form a tube or reservoir of neovascularized fibrocollagen. Preferably the biological material for implanting is a culture of live cells such as islets of Langerhans.
Patent NZ-516040-A (NZ)
Title: Improvements in and relating to metal box sections
Inventor: WATSON ROBERT LESLIE
IPC: F16S3/00
Filed: 2001-12-12
Abstract: A fabricated box-section comprises a pair of identical longitudinally folded metal strips (1).  The strips are longitudinally engaged within one another to form a box section.  Each strip is folded to comprise a first side (2) with a first channel (4) forming a return (3) along one longitudinal edge and a second return (6) along the opposite edge.  The second return is further folded to form a second side (8) disposed normal to the first side.  The second side terminates in a folded section (9) disposed in spaced parallel relationship opposite the second return.  The folded strips are joined together by longitudinally aligning the folded edge sections of each strip with the channels of the other strip and sliding the strips together into an overlapping engagement with each other.  The overlap can either be for their full lengths, or partial, that is, staggered.  Partial overlapping enables other strips to be engaged to the original strips in a continuation of this staggered overlapping relationship to form a continuous box section.  The strips can be crimped together.
Patent NZ-517634-A (NZ)
Title: Compositions and methods for L-nucleosides, L-nucleotides, and their analogs
Inventor: LAU JOHNSON
IPC: A61P29/00
Filed: 2000-12-19
Abstract: A compound of Formula 1 wherein R is PO32-, (PO3)23- or (PO3)34-, an antiviral drug comprising said compound and its use in the manufacture of a medicament for the treatment of a viral infection.
Patent NZ-524610-A (NZ)
Title: Composition containing a soluble potassium salt, a sodium alkylsulphonate, a polar surfactant and a carrier, use as a toothpaste, oral rinse, skin detergent, shampoo, hard surface cleaner and a fabric detergent
IPC: A61K33/00
Filed: 2000-03-10
Abstract: An aqueous detergent composition comprising an effective amount of a soluble potassium salt, a sodium (C8-C24) alkylsulfate in an amount effective to remove or loosen debris and/or stains from a surface, and a polar surfactant, said polar surfactant comprising a hydrophobic portion selected from the group consisting of a (C6-C30) alkyl group and a polymeric silicone group is disclosed, wherein the molar ratio of the surfactant to the sodium (C8-C24) alkylsulfate is greater than or equal to about 1:1 and wherein the pH of the composition ranges from 5 to 7. A method for inhibiting the formation of a potassium alkylsulfate precipitate in an aqueous detergent composition is also disclosed. (62) Divided out of 514069
Patent NZ-525223-A (NZ)
Title: Desensitising teeth with therapeutic agents directly adsorbed onto or encapsulated within a delivery agent substrate such as silica
Inventor: CURRO FREDERICK A
IPC: A61K6/00
Filed: 2001-10-10
Abstract: Described is a composition for the treatment of sensitive teeth comprising a desensitizing amount of: a substrate treated with a desensitizing agent, wherein substrate acts as a delivery vehicle of therapeutic agents for the treatment of hypersensitive teeth. The desensitizing agent is coated or adsorbed on the surface or attached to the surface of the substrate by a) chemical, electrostatic or ionic bonds; and/or b) encapsulated or impregnated within the substrate.
Patent NZ-527623-A (NZ)
Title: Serine protease inhibitor
Inventor: SCOTTI PAUL DOUGLAS
IPC: C12N1/19
Filed: 1999-12-23
Abstract: Disclosed is a protein which exhibits, inter alia, anti-thrombin activity and divalent metal cation binding activity. The protein can be readily extracted from the green-lipped mussel, Perna canaliculus, and formulated into foodstuffs, nutraceuticals and the like, and has a molecular weight of about 55 kDa and an amino acid sequence which includes one or more of the following: (a) DGEQCNDGQN (SEQ ID NO.1), (b) QGGHEVESERVACCVIGRA (SEQ ID NO. 2), (c) GQSHPEIVH (SEQ ID NO. 3), (d) YHGHDDA (SEQ ID NO. 4), (e) VVNEVHH (SEQ ID NO. 5) (62) Divided out of 512021
Patent NZ-527677-A (NZ)
Title: New salt of thiazolidinedione and its polymorphs as antidiabetic agents and method for obtaining them
Inventor: DEL CASTILLO NIETO JUAN CARLOS
IPC: A61P19/06
Filed: 2002-01-21
Abstract: Disclosed is the sodium salt of the compound 5-(4-{2-[(6-methoxy-pyrimydin-4-yl)-methyl-amino]-ethoxy}-benzyl)-thiazolidin-2,4-dione. A method for preparing the salt comprising reacting the compound with a source of sodium ions of base character. The compound is for use as an antihyperglycemic agent, an antihyperlipidemic agent and as an insulin sensitizer.
Patent NZ-528542-A (NZ)
Title: Inductively-powered power transfer system with one or more, independently controlled loads
Inventor: BOYS JOHN TALBOT
IPC: H02J5/00
Filed: 2003-09-29
Abstract: A system providing control of one or more operating units in an inductive power transfer (IPT) system. Each operating unit includes a pick-up coil that takes power from a primary conductor or track over an air gap. The operating unit is controlled by means of frequency modulation of the primary conductor power supply to send a control instruction which is decoded by the operating unit. The instruction is decoded by generating a signal using a local oscillator in the operating unit and using this signal to detect changes in the frequency of the current in the primary conductor. Applications include the control of inductively powered road-studs that include a light source, independent control of each device allowing, for example, the controlling of traffic on a roadway. A narrow band modulated data transmission system and method controlling of an operating unit are also provided.
Patent NZ-538043-A (NZ)
Title: Composition having a beneficial agent for forming a solid coating on microprojections array
Inventor: CORMIER MICHEL J
Filed: 2002-04-20
Abstract: A composition for forming a solid coating on microprojections 10 in a microprojection array 5 is disclosed. The composition contains a beneficial agent and at least one biocompatible carrier. The composition is applied to the microprojections in liquid form, wehere it subsequently forms a solid coating. The solid coating allows release of the beneficial agent upon hydration.
Patent NZ-541366-A (NZ)
Title: Monoclonal antibodies expressed by ATCC PTA-5643 for the manufacture of a medicament for the treatment of cancer
Inventor: YOUNG DAVID S F
IPC: C07K16/00
Filed: 2004-01-21
Abstract: Disclosed is the use of a monoclonal antibody or antigen binding fragment thereof which has the identifying characteristics of a monoclonal antibody encoded by a clone deposited with the ATCC as accession number PTA-5643, for the manufacture of a composition for treating a human tumor in a mammal, to reduce said mammal's tumor burden, whereby disease progression is delayed and/or survival is extended; and wherein said tumor expresses an antigen which specifically binds to a monoclonal antibody or antigen binding fragment thereof which has the identifying characteristics of a monoclonal antibody encoded by a clone deposited with the ATCC as accession number PTA-5643.
Patent NZ-541781-A (NZ)
Title: Novel compositions containing fentanyl
Inventor: ROSS CALVIN
IPC: A61P25/02
Filed: 2004-03-11
Abstract: Disclosed is a pharmaceutical liquid formulation comprising fentanyl as free base, water as carrier, a polar organic solvent in sufficient amount to enhance the solubility of the fentanyl in the water, and a buffer, wherein the pH of the formulation is 7.4 to 8.5.
Patent NZ-543209-A (NZ)
Title: Method for the preparation of molecular complexes
Inventor: LOCHARD HUBERT
IPC: A61K47/48
Filed: 2004-04-23
Abstract: Disclosed is a method for the preparation of soluble molecular complexes, comprising on or more active substances which are poorly-soluble in an aqueous medium, included within one or more host molecules, characterised in comprising the following steps: a) bringing one or more active substances into contact with one or more host molecules, b) carrying out a molecular diffusion step by bringing a dense fluid into contact, under pressure, with the mixture obtained in a), in static mode, in the presence of one or more diffusion agents and c) recovery of the molecular complex thus formed.
Patent NZ-544232-A (NZ)
Title: Substituted 1,4-di-piperidin-4-yl-piperazine derivative combined with an opioid analgesic and their use for the treatment of pain and side-effects associated with opoid-based treatments
Inventor: JANSSENS FRANS EDUARD
Filed: 2004-06-07
Abstract: Disclosed are formulations comprising opioid analgesics and 1,4-di-piperidin-4-yl-piperazine derivatives of formula (I), wherein the substituents are as defined in the specification, having neurokinin (NK1) antagonistic activity. The formulations are useful for opioid-based treatments of emesis, pain and/or nociception, in particular in opioid-based acute and chronic pain treatments including inflammatory, postoperative, emergency room (ER), breakthrough, neuropathic and cancer pain. The combination reduces a number of unwanted side­effects associated with opioid analgesics, in particular emesis, respiratory depression and tolerance, thereby increasing the total tolerability of said opioids in pain treatment.
Patent NZ-544418-A (NZ)
Title: Non sticky gum base for chewing gum
Inventor: SOZZI GIUSEPPE
IPC: A23G4/10
Filed: 2004-07-06
Abstract: Disclosed is a gum base formulation suitable for the production of a chewing gum with good sensory properties and good flavour release in combination with anti-adhesive properties in respect of teeth, dentures and the like typical of formulations containing polyvinyl acetate. This gum base formulation does not stick to teeth and it is characterized by having the following composition by weight: (a) elastomers, 9-16% (b) emulsifiers and/or technological auxiliaries 18-30% (c) adjuvants 15-22% (d) vegetable resins and/or vegetable resin esters 33-41% (e) antioxidants 0-2% and by not containing polyvinyl acetate.
Patent NZ-544768-A (NZ)
Title: Roadside post from spring steel deflects 90 degrees on impact and returns to upright position
Inventor: MUDRYK BOYDAN JOSEPH
IPC: E01F9/588
Filed: 2004-06-10
Abstract: A roadside post (10) comprises an elongate normally upright body (30) formed of sheet spring steel. The body (30, 130) is elastically bendable through 90 degree from an unbent state as is shown in the figure. The roadside post (10) may further comprise a rigid base (20) and the base may be inset below the ground surface (100) with bevelled edges (50, 51) of the inset allowing for full movement of the body (30).
Patent NZ-544857-A (NZ)
Title: Composite building panel and method of making composite building panel
Inventor: SMITH BRIAN
IPC: E04B1/04
Filed: 2004-07-21
Abstract: A composite panel and method of fabricating is provided which includes a frame having a plurality of spaced apart frame members, and a concrete slab made of aerated concrete having a density of 400 to 1760 kilograms per cubic metre (25 to 110 pounds per cubic foot). Fastened to the frame members is a reinforcing layer. The concrete slab, having a front face and a rear face, embeds the reinforcing layer and a portion of the frame such that the frame protrudes from the rear face of the slab. At least one tab and one tab opening is disposed on an embedded portion of the frame, and the concrete slab extends through the tab opening.
Patent NZ-546580-A (NZ)
Title: High throughput functional assay for G-protein coupled receptors using a rap-ras chimeric protein
Inventor: BURSTEIN ETHAN S
IPC: C12Q1/68
Filed: 2004-11-02
Abstract: Disclosed is a method of determining whether a substance is a ligand for a G-protein coupled receptor (GPCR), comprising: (a) providing a cell culture which comprises cells comprising a first nucleic acid which encodes a GPCR which increases or decreases cellular proliferation through a GPCR cascade in response to a ligand, a second recombinant nucleic acid which encodes a marker indicative of the extent of cellular proliferation, and a third recombinant nucleic acid encoding a Ras effector domain and a Rap input domain operably coupled to said Ras effector domain; (b) contacting said cell culture with a test compound; and (c) determining the level of cellular proliferation
Patent NZ-549449-A (NZ)
Title: HIV Integrase inhibitors
Inventor: HAN WEI
IPC: C07D471/04
Filed: 2005-03-09
Abstract: Disclosed are hydroxy (tetra- or hexa-)hydronaphthyridine dione compounds of Formula (I). The compounds are inhibitors of HIV integrase and inhibitors of HIV replication and are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
Patent NZ-553008-A (NZ)
Title: Printing material container
Inventor: WANIBE AKIHISA
IPC: B41J2/175
Filed: 2005-08-30
Abstract: A printing material container, attachable to a printing apparatus by being inserted in a predetermined insertion direction, is disclosed. The printing material container comprises a body that contains a printing material, a plurality of low voltage circuit terminals, and a plurality of high voltage circuit terminals. The low voltage circuit terminals are configured to contact a plurality of terminals of a low voltage circuit, provided with the printing apparatus at first positions when the printing material container is attached to the printing apparatus. A plurality of high voltage circuit terminals are configured to contact a plurality of terminals of a high voltage circuit provided with the printing apparatus at second positions, when the printing material container is attached to the printing apparatus. The first positions and the second positions are disposed on a same outer surface of the printing material container that is parallel to the insertion direction, where the second positions are arranged further towards the insertion direction side than the first positions.
Patent NZ-556308-A (NZ)
Title: Mill liner assembly
Inventor: ABARCA MELO RICARDO
IPC: B02C17/22
Filed: 2006-01-16
Abstract: A liner assembly is disclosed for use in a grinding mill, the liner assembly including a liner body including a mounting member, and an elastomeric cushioning member operatively connected to the mounting member. The cushioning member includes a plurality of support cavities therein, and a plurality of wear elements mounted within the support cavities.
Patent NZ-561822-A (NZ)
Title: Multivalent influenza virus vaccine
Inventor: HANON EMMANUEL JULES
IPC: A61K39/145
Filed: 2006-03-21
Abstract: Provided is a multivalent influenza immunogenic composition comprising an influenza antigen or antigenic preparation thereof from at least two influenza virus strains, at least one strain being associated with a pandemic outbreak or having the potential to be associated with a pandemic outbreak, in combination with an oil-in-water emulsion adjuvant, wherein said oil-in-water emulsion adjuvant comprises a metabolizable oil, a sterol and/or alpha tocopherol and an emulsifying agent. The metabolizable oil can be squalene. Further provided are methods of production of the compositions and use of the compositions in the manufacture of immunoactive medicaments.
Patent NZ-563477-A (NZ)
Title: Personal care formulations containing keratin
Inventor: KELLY ROBERT JAMES
IPC: A61Q1/10
Filed: 2003-11-28
Abstract: Disclosed is a personal care formulation including a S-sulfonated keratin protein fraction. The keratin protein fraction may be intact or hydrolysed. Preferably the keratin protein fraction is from the high sulfur protein family wherein the cysteine content of the keratin protein may be about 4%. (62) Divided Out of 540294
Patent NZ-567851-A (NZ)
Title: Bi-aryl meta-pyrimidine inhibitors of kinases
Inventor: CAO JON JIANGUO
IPC: C07D239/49
Filed: 2006-10-26
Abstract: Disclosed are substituted pyrimidine compounds of formula (A) where the substituents are as disclosed in the description. Examples of compounds of formula (A) are: N-tert-Butyl-2-methyl-5- { 5-methyl-2-[ 4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino ]-pyrimidin-4-ylamino} -benzenesulfonamide; N4-(3-tert-butylphenyl)-5-methyl-N2-( 4-(1-morpholinoethyl)-phenyl)pyrimidine-2,4-diamine Hydrochloride; and 4-[4-(4-Methoxy-phenylamino)-pyrimidin-2-ylamino ]-N -(2-pyrrolidin-1-yl-ethyl)-benzenesulfonamide trifiuoroacetate. The compounds are useful for JAK family kinase interactions. Also disclosed is a pharmaceutical composition comprising a compound of formula (A); the use of a compound of formula (A) in the manufacture of a medicament to treat an angiogenic-associated disorder and the method for making a compound.