Patent SG-11201811434R-A (SG)
Title: Antimalarial compositions and uses thereof
Inventor: ANDAHAZY WIL JOSEPH
IPC: A61P33/02
Filed: 2017-06-19
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1 MEM 0 11101 HOE 010 1111 1 0 01 OH OH OH 1101 IRO 111101111011 Iii Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\"1 WO 2017/222996 Al 28 December 2017 (28.12.2017) WIP0 I PCT (51) International Patent Classification: Jason T.; 15698 Via Montecristo, San Diego, California A61K 31/122 (2006.01) A61P 33/02 (2006.01) 92127 (US). WELLS, Timothy; Chemin des Cornillons A61K 31/215 (2006.01) CO7C 50/32 (2006.01) 40A, 1292 Chambesy (CH). ZATOLOCHNAYA, Olga (21) International Application Number: Vladimirovna; 50 Saw Mill Road, Apt. 14323, Danbury, PCT/US2017/038173 Connecticut 06810 (US). ZHOU, Fei; 4435 Nobel Drive, Unit 48, San Diego, California 92122 (US). SCHULTZ, (22) International Filing Date: Peter G.; 1650 La Jolla Rancho Road, La Jolla, California 19 June 2017 (19.06.2017) 92037 (US). (25) Filing Language: English (74) Agent: HARDT, Ingo H.; Wilson Sonsini Goodrich & Rosati, 650 Page Mill Road, Palo Alto, California 94304 (26) Publication Language: English (US). (30) Priority Data: (81) Designated States (unless otherwise indicated, for every 62/352,455 20 June 2016 (20.06.2016) US kind of national protection available): AE, AG, AL, AM, (71) Applicant: THE CALIFORNIA INSTITUTE FOR AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, BIOMEDICAL RESEARCH [US/US]; 11119 North Tor- CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, rey Pines Road, Suite 100, La Jolla, California 92037 (US). DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, — (72) Inventors: ANDAHAZY, Wil Joseph; 5684 Clouds Mill KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, Drive, Alexandria, Virginia 22310 (US). CHATTERJEE, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, Arnab K.; 13268 Torrey Crest Court, San Diego, Cali- OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, fornia 92129 (US). MCNAMARA, Case W.; 469 Chest- SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, nut Avenue, San Marcos, California 92069 (US). BEAS- TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = LEY, Federico C.; 7275 Calabria Court, #69, San Diego, California 92122 (US). ELIASEN, Anders Mikal; 7954 (84) Designated States (unless otherwise indicated, for every = _ Avenida Navidad, Apt. 97, San Diego, California 92122 kind of regional protection available): ARIPO (BW, GH, (US). PETRASSI, Hank Michael James; 4695 Serena- GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, to Place, San Diego, California 92130 (US). ROLAND, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = = (54) Title: ANTIMALARIAL COMPOSITIONS AND USES THEREOF = = FIG. 38 = = = 100000 2 c = = 10000 = = 1000 c ; rough :=. 1000 nM = = t 100 — = 10 U 11 10 0 15 ,tD Time (weeks) 01 01 ei ei ei Top curve (squares): Compound 33 (60 mg/kg) IN Bottom curve (circles): Compound 33 (20 mg/kg) 11 © (57) ei : Provided herein are compounds, compositions and method of using thereof to treat or prevent malaria. C [Continued on next page] WO 2017/222996 Al IMEDIMOM0101011MMEMODIOHOHOHEIERODEVOIMIE EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3))