Patent SG-11201811272Y-A (SG)
Title: Therapeutic compounds
Inventor: WELSH WILLIAM J
IPC: C07D241/04
Filed: 2017-06-16
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111411 0 11101 HOE 010 1111 1 0 01 OH OH OH Mil HMO 11110 1111 MI Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\"1 WO 2017/222930 Al 28 December 2017 (28.12.2017) WIP0 I PCT (51) International Patent Classification: Queens, Somerset and George Streets, New Brunswick, A61K 31/496 (2006.01) C07D 241/04 (2006.01) New Jersey 08901 (US). COMOLLO, Thomas Walter C07C 233/64 (2006.01) [US/US]; Old Queens, Somerset and George Streets, New (21) International Application Number: Brunswick, New Jersey 08901 (US). KIMANI, Stanley G. PCT/US2017/037895 [US/US]; Old Queens, Somerset and George Streets, New Brunswick, New Jersey 08901 (US). (22) International Filing Date: (74) Agent: MICKELSON, John W. et al.; 7851 Metro Park- 16 June 2017 (16.06.2017) way, Suite 325, Bloomington, Minnesota 55425 (US). (25) Filing Language: English (81) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of national protection available): AE, AG, AL, AM, (30) Priority Data: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 62/352,499 20 June 2016 (20.06.2016) US CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (71) Applicant: RUTGERS, THE STATE UNIVERSITY HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, OF NEW JERSEY [US/US]; Old Queens, Somerset and KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, George Streets, New Brunswick, New Jersey 08901 (US). MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (72) Inventors; and OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (71) Applicants: WELSH, William J. [US/US]; Old Queens, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Somerset and George Streets, New Brunswick, New Jer- sey 08901 (US). BIRGE, Raymond [US/US]; Old Queens, (84) Designated States (unless otherwise indicated, for every = Somerset and George Streets, New Brunswick, New Jer- kind of regional protection available): ARIPO (BW, GH, sey 08901 (US). KHOLODOVYCH, Vladyslav [US/US]; GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = — Old Queens, Somerset and George Streets, New Brunswick, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, — New Jersey 08901 (US). PENG, Youyi [US/US]; Old TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = — (54) Title: THERAPEUTIC COMPOUNDS — Figure 2A (57) : Certain compounds of formula I: I and salts including pharmaceutically = acceptable salts thereof are disclosed. Also disclosed are pharmaceutical compositions _ comprising a compound of formula I, processes for preparing compounds of formula = I, intermediates useful for formula I and therapeutic = = = preparing compounds of methods , TAT1 using a compound of formula I. B tn = = 0.5 = = ... * + Gas6 = 0.625 '25 2.5 5.0 Compound 11 _ (IC50 =1 15 pM) Il L' M Fe © N 'IR 2 en 0\ (I) f\"1 N N x2, IN 1-1 0 N C [Continued on next page] WO 2017/222930 Al MIDEDIMOMMIDIRMEMODEEDIEMMIHMEMOIMIE EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, SK, SM, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))