baber/WOPTO huggingface dataset:
Patent NZ-221923-A (NZ)
Title: Detoxified pseudomonas exotoxin, recombinant production, conjugates and compositions
Inventor: PASTAN IRA H
IPC: A61K47/48
Filed: 1987-09-23
Abstract: The present invention relates to various modified forms of Pseudomonas exotoxin exhibiting low toxicity to human or animal cells by itself but retaining its enzymatic activity. The modified Pseudomonas exotoxin of the present invention has ADP ribosylating activity but lacks all or part of domain II (responsible for translocation across cell membrane) of the native toxin. A preferred modified Pseudomonas exotoxin of the present invention further comprises a modification in the receptor binding domain IA of the native Toxin. Conjugates (immunotoxins) comprising a modified Pseudomonas exotoxin and a targeting carrier, such as an antibody or a growth factor, methods for producing a modified Pseudomonas exotoxin or conjugates thereof and compositions suitable for administration to a mammal for achieving targeted cytotoxin activity are also disclosed.
Patent NZ-250229-A (NZ)
Title: Tinting contact lenses by surface printing
Inventor: SU KAI CHIANG
IPC: G02B1/10
Filed: 1993-11-18
Abstract: A contact lens colorant formulation containing a non-ionic polyalkylene oxide surfactant is applied to a dry hydrophilic contact lens by means of a silicon rubber printing pad to provide a cosmetically acceptable, solid, unblemished covering. This process allows for a solid covering to be placed onto the lens in a single printing step using standard transfer printing devices.
Patent NZ-254823-A (NZ)
Title: Monitoring ovulation cycles in human females
Inventor: CATT MICHAEL
IPC: G01N33/68
Filed: 1993-08-10
Abstract: A method of monitoring the status of a current ovulation cycle of an individual human female subject, involving testing of the body fluid concentration of an analyte of significance in relation to the status of the ovulation cycle, such as urinary E3G, during at least part of the pre-ovulation phase of the current ovulation cycle of the individual subject, and identification from the results of such testing an analyte concentration change indicative of imminent ovulation, relative to an analyte concentration reference value that has been adapted to the individual human subject on the basis of analyte concentration test data obtained from the individual human subject during one or more previous ovulation cycles. Preferably testing for said analyte concentration during the current ovulation cycle is commenced a plurality of days (preferably at least 5) following the onset of menses but at least 2 numerical days in advance of the earliest numerical day on which actual ovulation has occurred in one or more previous ovulation cycles in the same individual subject.
Patent NZ-281011-A (NZ)
Title: Use of bicyclic pyrimidine derivatives with the other ring being a heteroaryl as medicaments; pyridopyrimidine compounds
Inventor: BRIDGES ALEXANDER JAMES
IPC: C07D487/02
Filed: 1995-01-23
Abstract: 4-substituted amino pyrido pyrimidine and 4-substituted amino pyrido pyrimidine inhibitors of the epidermal growth factor receptor family of tyrosine kinase are described in addition to pharmaceutical compositions of the same.  They are useful in treating proliferative diseases such as cancer, synovial pannus invasion in arthritis, psoriasis, vascular restenosis and angiogenesis and also useful in the treatment of pancreatitis and kidney disease and in use as a contraceptive agent.
Patent NZ-283988-A (NZ)
Title: Rapamycin hydroxyesters and medicaments
Inventor: SKOTNICKI JERAULD STANLEY
IPC: A61K31/00
Filed: 1995-04-14
Abstract: A compound of structure (I)   
wherein R 1  and R 2  are each, independently, hydrogen or - CO(CR 3 R 4 ) b (CR 5 R 6 ) d CR 7 R 8 R 9  ; 
R 3  and R 4  are each, independently, hydrogen, alkyl, alkenyl, alkynyl, trifluoromethyl, or -F; 
R 5  and R 6  are each, independently, hydrogen, alkyl, alkenyl, alkynyl, -(CR 3 R 4 ) f OR 10 , -CF 3 , -F, or -CO 2 R 11 , or R 5  and R 6  may be taken together to form X or a cycloalkyl ring that is optionally mono-, di-, or tri-substituted with - (CR 3 R 4 ) f OR 10 ; 
R 7  is hydrogen, alkyl, alkenyl, alkynyl, -(CR 3 R 4 ) f OR 10 , -CF 3 , -F, or -CO 2 R 11 ; 
R 8  and R 9  are each, independently, hydrogen, alkyl, alkenyl, alkynyl, -(CR 3 R 4 ) f OR 10 , -CF 3 , -F, or -CO 2 R 11 , or R 8  and R 9  may be taken together to form X or a cycloalkyl ring that is optionally mono-, di-, or tri-substituted with -(CR 3 R 4 ) f OR 10 ; 
R 10  is hydrogen, alkyl, alkenyl, alkynyl, tri-(alkyl)silyl, tri-(alkyl)silylethyl, triphenylmethyl, benzyl, alkoxymethyl, tri-(alkyl)silylethoxymethyl, chloroethyl, or tetrahydropyranyl; 
R 11  is hydrogen, alkyl, alkenyl, alkynyl, or phenylalkyl; 
X is 5-(2,2-dialkyl)[1,3]dioxanyl, 5-(2,2-dicycloalkyl)[1,3]dioxanyl, 4-(2,2-dialkyl)[1,3]-dioxanyl, 4-(2,2-dicycloalkyl)[1,3]dioxanyl, 4-(2,2-dialkyl)[1,3]dioxalanyl, or 4-(2,2-dicycloalkyl)[1,3]dioxalanyl; 
b = 0-6; 
d = 0-6; and 
f = 0-6 
with the proviso that R 1  and R 2  are both not hydrogen and further provided that either R 1  or R 2  contains at least one -(CR 3 R 4 ) f OR 10 , X, or -(CR 3 R 4 ) f OR 10  substituted cycloalkyl group, or a pharmaceutically acceptable salt thereof which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent.
Patent NZ-294383-A (NZ)
Title: Method of decontaminating soil containing hazardous metals using an ammoniacal liquid
Inventor: MOUK ROBERT W
IPC: C22B43/00
Filed: 1995-09-12
Abstract: Soil including sand and clays contaminated with nuclear waste materials are decontaminated by treating with anhydrous liquid ammonia alone or in combination with solvated electrons. Methods comprise concentrating radionuclides, such as plutonium and uranium in the fines of soil and clay to yield residual soil products which are sufficiently free of contaminants to allow reclamation. Economics are improved over aqueous systems since ammonia can be recovered and recycled. By concentrating nuclear wastes in soil fines space requirements ordinarily needed for storage of untreated soil and handling costs can be significantly reduced.
Patent NZ-326003-A (NZ)
Title: Control of healing process using hirudine, a thrombin inhibitor or a fibrinolytic agent
Inventor: HANSSON HANS ARNE
IPC: A61K31/731
Filed: 1997-01-16
Abstract: Hirudine, a hirudine fragment thereof, a low molecular weight peptide based thrombin inhibitor or a fibrinolytic agent is used in the manufacture of a product for use in the control of wound healing processes within the body, in the inhibition or prevention of fibrin related adhesion or in the inhibition or prevention of scar tissue formation. The product can comprise a fibrinolytic agent in combination with the hirudine, a hirudine fragment thereof or a low molecular weight peptide based thrombin inhibitor. A low molecular weight peptide based thrombin inhibitor is used in the manufacture of a product for use in the prevention or reduction of the activation and aggregation of thrombocytes.
Patent NZ-330228-A (NZ)
Title: Process for preparing azithromycin using a noble metal catalyst and hydrogen in the presence formaldehyde
Inventor: HEGGIE WILLIAM
IPC: A61P31/04
Filed: 1998-04-20
Abstract: Azithromycin is prepared from an imino ether by carrying out the reduction and reductive methylation sequentially with a noble metal catalyst and hydrogen in the presence of formaldehyde, or a source thereof, both reactions being conducted in the same reaction vessel.
Patent NZ-331581-A (NZ)
Title: Smokable filler material for smoking articles that mimics tobacco comprising an aerosol generating means, a non-combustible inorganic filler, a binder, an extract from a flavour fuel source material and optionally a biopolymer
Inventor: MCADAM KEVIN GERARD
IPC: A24B15/16
Filed: 1997-03-04
Abstract: The smokable material comprises: a) 2-30% weight of an aerosol generating means, b) 20-80% weight of an inorganic filler material, c) 5-25% weight pectinaceous binder and d) 1-30% weight of an extract of flavour fuel material wherein if the filler material further comprises one or more cellulose biopolymers commonly found in plant material then the cellulose is not pre-treated.
Patent NZ-332340-A (NZ)
Title: 4-(aryl or heteroaryl) substituted benzofurancarboxamide derivatives and medicaments
Inventor: DYKE HAZEL JOAN
IPC: C07D307/79
Filed: 1997-05-20
Abstract: A compound of general formula (I) or a pharmaceutically acceptable salt thereof is claimed wherein: Z is CO or CS; R1 is optionally substituted alkoxy; R2 and R3 are independently H, R6, OR10, COR6, C(=NOR6)R6, alkyl-C(=NOR6)R6, alkyl-C(=NOH)R6, C(=NOH)R6, halogen, NR8R9, CF3, CN, CO2H, CO2R10, CONH2, CONHR6 or CON(R6)2; R4 represents H, arylalkyl, heteroarylalkyl, heterocycloalkyl, S(O)mR10 or optionally substituted alkyl; R5 represents aryl, heteroaryl, heterocyclyl, arylalkyl, heteroarylalkyl or heterocycloalkyl; m is an integer of up to 2; n represents 0 to 2 and R6, R8, R9 and R10 are as defined in the specification. A pharmaceutical composition containing a compound of formula I useful in the treatment of a disease state capable of being modulated by inhibition of phosphodiesterase IV or tumour necrosis factor is claimed.
Patent NZ-332646-A (NZ)
Title: Vibration damper for appliance body, plate attached to body by visco-elastic adhesive layer
Inventor: SHAFFER ROY
IPC: F16F9/30
Filed: 1997-05-23
Abstract: A vibration damping material for the sides of metal appliance bodies, such as washing machines, consists of a constraining layer 12 and an adhering layer 13. The adhering layer includes a viscosity enhancing material such as a cellulose fibre, and an adhesive.  The constraining layer is adhered to a surface by the adhering layer.
Patent NZ-500586-A (NZ)
Title: A safe sex barrier and intravaginal drug delivery device that can deliver drugs and/or other agents topically or systemically via the vaginal musoca
Inventor: CONTENTE AUDREY
IPC: A61F5/455
Filed: 1998-03-26
Abstract: A device is provided for reliably, comfortably and conveniently introducing agents, including drugs and other substances, into the vaginal canal.  A discharge collection device (10) is also disclosed.  The disclosed devices may be formed of an elastomeric rim (11) and a flexible film.  The rim may have a non-circular cross section (406).  The film may be collapsible into a low profile insertion configuration.  The devices may be disposable, and are constructed to be convenient to use and comfortable to wear internally.  Preferably, the devices are formed from a thermoplastic material that softens in response to body temperature to provide improved comfort and handling. Although the rim (252") has a generally figure-eight-shaped cross-sectional configuration, it may have other cross-sectional configurations.  For example, the encapsulating material (406) (surrounding the O-rings 402, 404) may be provided with the D-shaped cross-sectional configuration of the rim (252').
Patent NZ-502206-A (NZ)
Title: Fastener having an acrylic-based polymer coating covering at least part of the shank
Inventor: LAT GERONIMO E
IPC: F16B25/00
Filed: 2000-01-07
Abstract: Nail 12 has an acrylic-based polymer coating 34 covering at least part of shank 20.  The polymer allows for reduced resistance to driving into and removal from wood.  The coating is formed by heating nail 12 (to effect hardening) and quenching in water.  Details of heating and quenching and the coating are disclosed.
Patent NZ-502820-A (NZ)
Title: Heteroaryl or aryl substituted carboxylic acid or carboxamide derivatives optionally substituted with a sulphonamido group
Inventor: MCCAFFREY PATRICIA
IPC: C07D211/60
Filed: 1998-08-27
Abstract: A compound of the formula (I) and its derivatives can be used, either alone or in conjunction with a neurotrophic factor, such as nerve growth factor, to promote repair of neuronal damage caused by disease or physical trauma, where: A and B are H, Ar, or optionally substituted alkyl, alkenyl or alkynyl, where any one of the CH2 groups of alkyl, alkenyl or alkynyl chains in A or B is optionally replaced by O, S, S(O), S(O)2 OR N(R); Ar is defined in the specification; n is 0 - 2; X is N, O or C(R), when X is N or C(R), Y is H, Ar, or optionally substituted alkyl, alkenyl or alkynyl and when X is O, Y is a lone pair of electrons; R is H, alkyl, alkenyl or alkynyl; K is optionally substituted alkyl, alkenyl or alkynyl, or cyclohexylmethyl, where any one of the CH2 groups of alkyl, alkenyl or alkynyl chains in K is optionally replaced by O, S, S(O), S(O)2 OR N(R); J is H, optionally substituted alkyl, alkenyl or alkynyl, or cyclohexylmethyl D is Ar, or optionally substituted alkyl, alkenyl or alkynyl, or cyclohexylmethyl, where any one of the CH2 groups of alkyl chains in D other than the one that is directly bound to the S(O)2 is optionally replaced by O, S, S(O), S(O)2 OR N(R); and that the compound of formula (I) is not (S)-(2-(5-(dimethylamino)-1-naphthalenesulfanilamido)-3-phenyl)carboxylic acid, 1-(pyridin-4-yl) propyl ester or (S)-(p-toluenesulfanilamido)-3-phenyl-N-(2-pyridin-2-yl)methyl)propionamide; and provided that (i) when X is N, n is 0 and Y is H or alkyl; or (ii) when X is O n is 0; or (iii) when X is C-H, n is 0 and Y is H; then D is Ar, or optionally substituted alkyl, alkenyl or alkynyl, or cyclohexylmethyl, where any one of the CH2 groups of alkyl chains in D other than the one that is directly bound to the S(O)2 is optionally replaced by O, S, S(O), S(O)2 OR N(R).
Patent NZ-505865-A (NZ)
Title: Method for cell lysis continuously producing a mixture of nucleated cells and lysing agent , the mixture flows in a steady stream through a tube having a diameter of 1cm or less
Inventor: CHEVALIER MICHEL
IPC: C12M1/00
Filed: 1999-01-20
Abstract: A method and a device for cell lysis which continuously produces a liquid mixture of bacteria or erkaryiotic cells and a lysis agent, and in immediately caused said mixture to flow in a constant flux inside a pipe (7), the flow rate of said flux being adapted , according to the pipe (7) length and diameter, so as to obtain a substantially homogenous lysate at said pipe (7) outlet.
Patent NZ-506221-A (NZ)
Title: HIV proteins with similarity to chemokines
Inventor: LUDWIG LINDA B
IPC: C07K14/16
Filed: 1999-02-12
Abstract: A gene is provided comprising an open reading frame encoded on the plus strand of the pro-viral DNA, and located in the region of HIV-1 long terminal repeat. The gene encodes a protein that is related to, and has a structural motif resembling that of chemokine proteins. Depending upon the ribosomal frame shift, a plurality of proteins may be translated from the antisense RNA. The protein has similarity with chemokine SDF-1 and may play a role as a cofactor with gp120 in the binding to and entry of HIV to a target cell.
Patent NZ-512792-A (NZ)
Title: Stable liquid interferon beta formulations
Inventor: DIBIASI MARY D
IPC: A61K47/18
Filed: 2001-07-05
Abstract: A liquid pharmaceutical composition comprising (a) an interferon, (b) an acetate and (c) arginine; where the composition has a pH within the range of 4.0 to 6.0. A process for stabilizing interferon in liquid pharmaceutical composition comprising admixing: (a) interferon; (b) an acetate buffer; and (c) arginine, where the composition has a pH within the range of 4.0 to 6.0.
Patent NZ-515146-A (NZ)
Title: Method and device for forming particles
Inventor: BOISSIER CATHERINE
IPC: B01F5/06
Filed: 2000-05-04
Abstract: A method for forming particles of a substance, comprising the step of introducing into a mixing chamber (8), in which the temperature and pressure are controlled, a fluid gas (4) and at least one vehicle system (1) comprising at least one substance in solution or suspension such that droplet formation and extraction of the vehicle occur substantially simultaneously by the action of the fluid gas (4).  Turbulence is induced in at least one of said fluid gas (4) and said vehicle system (1) so as to create a controlled disorder in the flow of the at least one of the fluid gas (4) or the vehicle system (1) in order to control the particle formation in said mixing chamber (8), said controlled disorder being created by at least one flow perturbation means (11).  The invention also relates to a mixing chamber having at least one flow perturbation means (11) that is disposed for interacting with at least one of a fluid gas (4) or vehicle system (1) supplied by the at least one supply member (4, 5) so as to induce turbulence or limited disorder in the at least one of the fluid gas (4) or vehicle system (1).
Patent NZ-517901-A (NZ)
Title: Adjuvant comprising a polyxyethylene alkyl ether or ester and at least one non-ionic surfactant
Inventor: FRIEDE MARTIN
IPC: A61P37/08
Filed: 2000-09-22
Abstract: An adjuvant composition comprising a)polyoxyethylene alkyl ether or ester of general formula (I): HO(CH2CH2O)n-A-R, wherein n is 1-50, A is a bond or-C(O)-, R is C1-50 alkyl or phenyl C1-50 alkyl; and b) at least one additional non-ionic surfactant, wherein additional non-ionic surfactant is an octoxynol. Also described is a vaccine containing the adjuvant composition and a process for making it.
Patent NZ-523049-A (NZ)
Title: A bed absorption system
Inventor: HUBBUCH JURGEN
IPC: B01J8/18
Filed: 2001-05-10
Abstract: Disclosed is an expanded fluid bed system for use in treating a fluid by contacting the fluid with a solid phase medium which system is operating under plug flow conditions, wherein the system comprises a reactor chamber adapted to contain the solid phase media and at least one rotating fluid distribution means adapted to distribute and deliver the fluid to be treated among the particles of the medium in a substantially uniform manner over a cross-sectional area of the bed.
Patent NZ-523088-A (NZ)
Title: Process for the preparation of substituted octanoyl amides, the compounds and intermediates thereof
Inventor: HEROLD PETER
IPC: C07D303/40
Filed: 2001-06-26
Abstract: A process for the preparation of 2 (S),4 (S),5 (S),7(S)-2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoyl amides of formula (I) and their physiologically acceptable salts, and the new compounds used as intermediates in the multistage process is disclosed, wherein the double bond of 2,7dialkyl-8-aryl-4-octenic acid or 2,7-dialkyl-8-aryl-4-octenic acid ester of formula (II) is simultaneously halogenated in the 5 position and hydroxylated in the 4 position under lactonization, the halolactone is converted to a hydroxylactone and then the hydroxy group is converted to a leaving group, the leaving group substituted with azide, the lactone amidated and then the azide converted to the amine group, in order to obtain octanoyl amide compounds of formula (I), and wherein: wherein: R1 and R2 are, independently of one another, H, C1-C6alkyl, C1-C6halogenalkyl, C1-C6alkoxy, C1-C6alkoxy-C1-C6alkyl, or C1-C6alkoxy-C1-C6alkyloxy; R3 is C1-C6alkyl; R4 is C1-C6alkyl; and R5 is C1-C6alkyl, C1-C6hydroxyalkyl, C1-C6alkoxy-C1-C6-alkyl, C1-C6alkanoyloxy-C1-C6alkyl, C1-C6aminoalkyl, C1-C6alkylamino-C1-C6-alkyl, C1-C6-dialkylamino-C1-C6-alkyl, C1-C6alkanoylamido-C1-C6-alkyl, HO(O)C-C1-C6-alkyl, C1-C6alkyl-O(O)-C-C1-C6alkyl, H2N-C(O)-C1-C6alkyl, C1-C6alkyl-HN-C(O)-C1-C6alkyl or (C1-C6alkyl)2N-C(O)-C1-C6-alkyl.
Patent NZ-523125-A (NZ)
Title: Alternator testing method and system using ripple detection
Inventor: THIBEDEAU DENNIS G
IPC: G01R31/34
Filed: 2001-06-26
Abstract: To provide and indication of the correct operation of an alternator and in particular the functioning of the diode rectifiers, the ripple frequency of the alternator rectified output is compared with a threshold frequency (as determined by the engine speed) and if the ripple frequency does not exceed the threshold frequency this indicates a malfunction of the alternator.
Patent NZ-523254-A (NZ)
Title: Method of delivering a large therapeutic mass aerosol to the pulmonary system
Inventor: EDWARDS DAVID A
IPC: A61K38/27
Filed: 2001-06-08
Abstract: Respirable compositions that may be suitable for delivery to the pulmonary system comprising carrier particles having a tap density of less than 0.4 g/cm3 and a composition comprising an agent are disclosed, wherein an agent can be delivered to the pulmonary system, in a single, breath-activated step or a single breath, that may be administer from a receptacle enclosing a mass of particles, particles which have a tap density of less than 0.4 g/cm3, and deliver at least about 50 % but not less than 5mg of the mass of particles to a subject's respiratory tract. These particles are capable of carrying agents. The agent may be: 1) part of the spray-drying pre-mixture and thereby incorporated into the particles; 2) added to separately-prepared particles so that the agent is in chemical association with the particles; or 3) blended so that the agent is mixed with, and co-delivered with the particles.
Patent NZ-529137-A (NZ)
Title: Vehicle with retractable wheel
Inventor: ROYLE DAVID ALBERT CYRIL
IPC: B60G17/02
Filed: 2002-04-29
Abstract: A vehicle having a wheel which is movable between a lower position and a raised position by a wheel retraction and lowering mechanism is described, the mechanism including a guide to determine the path of the wheel during retraction, said guide being in the form of a pillar, and characterised in that a lower portion (c;16) of which is slidable relative to an upper portion (B;14) whereby the length of the pillar is less when the wheel is in its retracted position than when it is in its lowered position.
Patent NZ-540123-A (NZ)
Title: Retractable mooring cleat having members extending from surface on divergent paths
Inventor: STRONG NATHAN PAUL
Filed: 2005-05-18
Abstract: A mooring cleat that is able to automatically retract into the deck or other surface of a boat is disclosed. The cleat includes a frame with an upper surface 3 from which first and second members 1, 2 extend along diverging paths. The members are driven by an actuation mechanism 5, 22, 23 and in the retracted position are either below or flush with the upper surface. A mooring line tied around the extended members will automatically be released when the members move to the retracted position.
Patent NZ-550501-A (NZ)
Title: Use of a fermentation product of propionic acid bacterium for treating inflammatory bowel diseases
Inventor: UCHIDA MASAYUKI
IPC: A23L1/30
Filed: 2005-04-13
Abstract: Disclosed is the use of a fermentation product of a propionic acid bacterium belonging to the genus Propionibacterium, for the manufacture of a medicament for treating an inflammatory bowel disease.
Patent NZ-550610-A (NZ)
Title: Method and auxiliary device for the underwater disassembly/assembly of a tunnel thruster
Inventor: ANDERSSON LARS-GORAN
IPC: B63H25/42
Filed: 2005-04-12
Abstract: A method in connection with disassembly and/or assembly of a tunnel thruster unit 2 by using an auxiliary device 1 for guiding the thruster unit 2 and its movement during disassembly/ assembly inside the tunnel, the method comprising transporting the thruster unit 2 through the tunnel, and irremovably fixing the auxiliary device 1 at the thruster unit 2 before final disassembly/assembly, such that the auxiliary device 1 controls the movement during disassembly/assembly, mainly by compressive forces.
Patent NZ-553580-A (NZ)
Title: Three rotating circular floating solar platforms that follow the sun
Inventor: LAING NIKOLAUS JOHANNES
IPC: F24J2/52
Filed: 2005-09-07
Abstract: A system for generating solar electricity has three platforms (5, 6, 7), which float on water and rotate to follow the sun. The platforms (5, 6, 7) include troughs (9) which have lenses that focus light on their photocells and can pivot on their horizontal axis. Each platform (5, 6, 7) is surrounded by a ring (10) which is held between three rollers (12). One roller (12) is driven by a motor, which turns the rings (10) and the other rollers (12). At least one roller (12) rolls the inner surface of each ring (10) and at least one roller (12) rolls the outer surface. The troughs (9) pivot and the platforms (5, 6, 7) rotate so the sunlight stays focused on the photocells.