baber/WOPTO huggingface dataset:
Patent EA-201992326-A1 (EA)
Title: Композиции и способы оказания направленного воздействия на альфа-v бета-3-положительные раковые стволовые клетки (csc) и лечения (avb3) лекарственно-устойчивых видов рака
IPC: C07K14/435
Filed: 2018-03-30
Abstract: Предоставлены композиции и способы лечения или ослабления рака путем направленного воздействия на экспрессируемые на клеточной поверхности полипептиды v3 (avb3) в раковых стволовых клетках (CSC) для уничтожения CSC, таким образом, для лечения, ослабления или замедления развития рака, вызванного, или инициированного, или поддерживаемого раковыми или опухолевыми клетками или раковыми стволовыми клетками (CSC), экспрессирующими полипептиды v3 на своих клеточных поверхностях. Предоставлены композиции и способы для осуществления направленного воздействия и уничтожения v3-положительных раковых стволовых клеток (CSC) и лечения лекарственно-устойчивых форм рака. В альтернативных вариантах осуществления в композициях и способах, предлагаемых в настоящей заявке, используют антитело, которое может специфически связываться с человеческим v3 и которое содержит Fc-участок, способный опосредовать антителозависимую клеточно-опосредованную цитотоксичность (ADCC), уничтожающую раковые или опухолевые клетки посредством макрофагов; например, используют гуманизированное анти-v3 антитело, которое модифицировано путем включения сконструированного Fc-участка, специфически связывающегося с макрофагами человека.
Patent EA-201992522-A1 (EA)
Title: КОМБИНАЦИЯ БИСПЕЦИФИЧЕСКОГО АНТИТЕЛА К ErbB-2/ErbB-3 С ЭНДОКРИННОЙ ТЕРАПИЕЙ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ
IPC: C07K16/32
Filed: 2018-05-17
Abstract: Настоящее изобретение относится к способам лечения субъекта, страдающего от рака молочной железы или подверженного риску развития указанного рака, включающим введение субъекту, нуждающемуся в этом, комбинации терапевтически эффективного количества биспецифического антитела к ErbB-2/ErbB-3 и терапевтически эффективного количества лекарственного средства для эндокринной терапии, причем указанное биспецифическое антитело имеет антигенсвязывающий сайт, который может связывать внеклеточную часть ErbB-2, и антигенсвязывающий сайт, который может связывать внеклеточную часть ErbB-3; а также к средствам для применения в указанном способе.
Patent EA-202190765-A1 (EA)
Title: Растворы золпидема или его фармацевтически приемлемых солей для оромукозного введения
IPC: A61K31/437
Filed: 2019-10-04
Abstract: Настоящее изобретение относится к составам на основе золпидема или его фармацевтически приемлемой соли для трансбуккального или подъязычного введения. Составы минимизируют количество способствующих проникновению средств и также обеспечивают быстрое трансмукозное проникновение лекарственного средства. Эти составы не только обеспечивают требуемую концентрацию (0,5-10% вес./об.) лекарственного средства в форме прозрачного раствора, но также обеспечивают стабильные составы в течение всего срока годности, составляющего по меньшей мере приблизительно 2 года. рН стабильных неводных растворов по настоящему изобретению находится в диапазоне 5-9, предпочтительно 6-9, более предпочтительно 7-9.
Patent ES-2172412-A1 (ES)
Title: Process for preparing cutting lubricant fluids
Inventor: OCCHIENA GIANCARLO
IPC: C10M177/00
Filed: 2000-07-21
Abstract: The process starts from A) an oil phase B) an aqueous phase C) a bactericidal fungicide and D) high pressure components, proceeding in situ by successively mixing said components with water, at the site of use, the proportions of the components varying in accordance with the type of machining and metal to be machined. The basic components are divided into composition sub-groups for their allocation to different machining states. It allows mixing of the components to be carried out in the appropriate lubricant reservoir of the cutting machine.
Patent ES-2166339-A1 (ES)
Title: Fruit harvester mounted on a tractor
Inventor: PAVONE OSVALDO
IPC: A01D46/26
Filed: 2000-07-31
Abstract: Fruit harvester mounted on a tractor that has a main frame that can be raised pivotally on a tractor to carry out an ascending and descending movement with relation to it, a hydraulic activator connectable between the tractor the main frame upwards and downwards in relation to the tractor, the activator being controllable manually of the main frame by a tractor driver. A pair of attached collector portions are mounted pivotally on the main frame to produce a lateral opening and closing movement to allow the fruit harvester to be moved by the tractor when the collector portions are in the open position, in order to place the collector portions on opposite sides of the tree, so that the collector portions can eventually be made to pivot as far as the closed position in which the collector portions remain surrounding the tree.
Patent ES-2185467-A1 (ES)
Title: Hydrogenation of conjugated diene polymers employs catalyst composition comprising titanium compound(s), silyl hydride compound(s) and (organo)metallic compound(s)
Inventor: TSAI JING-CHERNG
IPC: B01J31/38
Filed: 2000-12-20
Abstract: Conjugated diene polymers are hydrogenated in the presence of hydrogen and a hydrogenation catalyst composition comprising: (A) bis(cyclopentadienyl) titanium compound(s) (B) monomeric, polymeric and/or cyclic silyl hydride and/or silazane and (C) organoaluminum compound, organolithium compound, organozinc compound, lithium hydride and/or lithium alkyl oxide. Hydrogenation of conjugated diene polymers comprises hydrogenating the polymer in the presence of hydrogen and a hydrogenation catalyst composition. The catalyst composition comprises: (A) titanium compound(s) of formula (a) (B) monomeric silyl hydride of formula (i), polymeric silyl hydride of formula (ii), cyclic silyl hydride of formula (iii) and/or silazane of formula (iv) or (v) and (C) organoaluminum compound, organomagnesium compound, organolithium compound, organozinc compound, lithium hydride and/or LiOR3. R1, R2 = halo, alkyl, aryl, aralkyl, cycloalkyl, aryloxy, alkoxy or carbonyl Cp asterisk = cyclopentadienyl of formula C5R5 R5 = H, alkyl, aralkyl or aryl X1-X3 = H, halo, alkyl, aryl, aralkyl, cycloalkyl, aryloxy, alkoxy, acyloxy or carboxylate R, Ra-Rc = H, halo, alkyl, aryl, aralkyl, cycloalkyl, aryloxy or alkoxy n = at least 0 (for ii) and 2-5 (for (iii) and R3 = alkyl, aryl, aralkyl or cycloalkyl.
Patent ES-2188361-A1 (ES)
Title: Machine for cutting slate in irregular shapes.
Inventor: LOPEZ VIDAL ANA ISABEL
IPC: B28D1/32
Filed: 2001-04-04
Abstract: Machine for cutting slate in irregular shapes that includes a rotating table (1) activated by a motor (2) with several arms (3) radially, that along the end mount plates (4) supporting a piece of slate said table performs a circular trajectory, and stops at fixed positions that correspond to an initial load, another expulsion final load and various intermediate workstations.
Patent ES-2199018-A1 (ES)
Title: Needlepunched und thermal bonded nonwoven fabric, process and use
Inventor: PERMANYER ROCA XAVIER
IPC: B32B5/06
Filed: 2001-04-19
Abstract: A textile sheet material and process and corresponding use are disclosed. The textile sheet material comprises a layer of needle punched textile material having two fibre types (7, 9), with different melting points, having at least one physical property with different values, in such a way that these different values allow at least partial lamination of the fibre types (7, 9). The process comprises the following steps: ÄaÜ blending the types of fibres (7, 9) ÄbÜ carding the blend of fibres until a sheet is obtained ÄcÜ lamination ÄdÜ heating of the hidden face (5) of the sheet and ÄeÜ forming the sheet. The preferred uses are for the production of automobile components such as floor carpets, trunk carpets and wheel arch carpets.
Patent ES-2208128-A1 (ES)
Title: Apparatus for making a food product
Inventor: MORITO TOSHIMITSU
IPC: A21D8/00
Filed: 2001-11-13
Abstract: Confectionery, such as a tart and pie, is sequentially made. A generally rectangular mold is filled with food dough. The food dough is baked and taken out of the mold. The food dough is cut and divided in a zigzag pattern into generally triangularly-shaped food dough, so that a tart or a pie is made.
Patent ES-2246623-A1 (ES)
Title: Expository support element for cutlery piece, has groove extended throughout surface of complete or incomplete form with section in form of tail, where cutlery piece is held in exhibitors
Inventor: BLEDA PARADA VICTORIANO JOSE
IPC: A47F7/00
Filed: 2003-02-12
Abstract: The element has a groove extended throughout a surface of complete or incomplete form with a section in form of a tail. A cutlery piece is held in exhibitors.
Patent ES-2229888-A1 (ES)
Title: Volumetric dispenser of bakery dough includes dispensing chamber volume selector with two control pistons
Inventor: LAREDO ALVAREZ ANGEL FRANCISCO
IPC: A21C5/02
Filed: 2003-04-10
Abstract: The volumetric dispenser of bakery dough has a telescopic second piston (6) on the dispensing piston (5) in the chamber (4) of the oscillating drum (1) under the dispensing funnel (2). A separator (3) selects the individual chamber volumes for the required dough volumes.
Patent ES-2253030-A1 (ES)
Title: Opening device for automatic metering system has cable guide for facilitating backward movement of cable to initial position
Inventor: ROCA ROCA JOSEP
IPC: A01K5/02
Filed: 2003-06-13
Abstract: A compressible ball reduces in volume for the ball to ascend. A cable running along the interior of an inner wharf crosses an internal cover that acts as a counterbalance. A cable guide in the inner wharf facilitates the exit of the cable to prevent friction with the cable during displacement of the cable. The cable guide facilitates the backward movement of the cable to an initial position.
Patent ES-2238909-A1 (ES)
Title: Portable information device
Inventor: RODRIGUEZ MARTINEZ ALFONSO
IPC: G06F1/16
Filed: 2003-08-07
Abstract: The invention relates to a portable information device. The inventive device consists of a screen comprising a base structure (1) which is adequately dimensioned such as to house a power source, said source rendering the assembly autonomous, a transmitter/receiver, a connection unit with computer keyboard and the necessary hardware in order to power an information display screen (5) which is separate from the base structure (1). The aforementioned display screen (5) is disposed in a support structure (6) which is suitably raised in relation to the base structure and which is connected to said base by means of a tubular column (4) housing the power wiring for the screen (5). In addition, the assembly is supported by a rolling platform (2) which enables the position of the portable information screen to be changed easily and conveniently. In this way, the information supplied by the device is dynamic and alterable in real time and, in addition, the physical position thereof can be changed.
Patent ES-2257910-A1 (ES)
Title: Advanced telescopic prop for vehicle bodywork, has safety device that prevents assembly of canvas or sailcloth of truck when latch of prop is not working, anchored or fixed
Inventor: GONZALVO BORGE PASCUAL
IPC: B62D33/02
Filed: 2004-02-12
Abstract: The prop is used to set a bodywork vertically upright on a panel or lateral wall of a box or container of a loading vehicle or truck. The telescopic prop has safety device that prevents the assembly of the canvas or sailcloth of the truck when the latch of the prop is not working, anchored or fixed.
Patent ES-2277482-A1 (ES)
Title: Revolving piece for steering wheels of vehicles e.g. cars, buses includes activating mechanism having ball cushions, ball bearings, gears, devices with central axis, pulleys, straps or hydraulic devices
Inventor: ARTEAGA GONZALEZ CANDIDO
IPC: B62D1/04
Filed: 2004-06-22
Abstract: A support point and a lever are provided to a conductor to turn the steering wheel left and right, to maneuver for parking, and to maneuver at low speed. A contact or visible portion has a circular form and adheres to the palm of the hand. An activating mechanism includes ball cushions, ball bearings, gears, devices with a central axis, pulleys, straps or hydraulic devices.
Patent ES-2255834-A1 (ES)
Title: New 1,2,4-triazole-3-carboxamide derivatives
Inventor: HOLENZ JORG
IPC: A61K31/4196
Filed: 2004-09-14
Abstract: The invention relates to new 1,2,4-triazole-3-carboxamide derivatives, as well as to their use for the treatment of diseases in which cannabinoid receptors are involved.
Patent ES-2251317-A1 (ES)
Title: New fused pyrazole derivatives, useful for treatment of psychosis and pain, are sigma receptor inhibitors
Inventor: CORBERA ARJONA JORDI
IPC: C07D231/54
Filed: 2004-10-14
Abstract: Fused pyrazole derivatives (I) are new. Fused pyrazole derivatives of formula (I) and their salts, isomers, prodrugs or solvates are new. R 1, R 5, R 6 = H, alkyl, cycloalkyl, heterocyclyl, aryl, arylalkyl or heterocyclylalkyl (all optionally substituted) R 2 = H, alkyl, cycloalkyl, alkoxy, aryl, heterocyclyl, arylalkyl or heterocyclylalkyl (all optionally substituted) R 3, R 4 = H, alkyl, cycloalkyl, heterocyclyl, aryl, arylalkyl or heterocyclylalkyl (all optionally substituted) or CR 3R 4 = 3-6 membered ring (optionally substituted) and/or NR 5R 6 = 3-7 membered ring (optionally substituted) dotted line = single or double bond n = 0-2 m = 0-4. provided that when R 1 = phenyl, R 2 = H, dotted line = double bond, m = 1 and NR 5R 6 = 2,5-dioxopyrrolidino or 5-ethoxy-2-oxo-pyrrolidino, then R 3 and R 4 are not both H or methyl. An independent claim is also included for preparation of (I). [Image] ACTIVITY : Antidiarrheic Antilipemic Anorectic Antimigraine Antiarthritic Hypotensive Antiarrhythmic Antiulcer Ophthalmological Nootropic Tranquilizer Neuroprotective Antiaddictive Antismoking Alcoholism Cerebroprotective Vasotropic Anticonvulsant Analgesic Cytostatic Antidepressant Neuroleptic Antiinflammatory Immunosuppressive. MECHANISM OF ACTION : Sigma (sigma-1 and sigma-2) receptor inhibitor. Brain membrane preparation and binding assays for the sigma-1 receptor (as described by DeHaven-Hudkins et.al., 1992) and for the sigma-2 receptor (as described by Radesca et.al., 1991) were performed using 4,5,6,7-tetrahydro-4-(2-(isoindolin-2-yl)ethyl)-1-phenyl-1H-indazole oxalate (A). The K i of (A) for 0.3 nM and 1.4 nM for sigma-1 and sigma-2 binding respectively.
Patent ES-2255440-A1 (ES)
Title: Fabrication of polyurethane doors simulating wood consists of production of a flexible mould from a grained wood prototype, with matched graining or the poured polyurethane
Inventor: ANGUIANO MARTINEZ JACINTO JAVI
IPC: B29K75/00
Filed: 2004-12-01
Abstract: The fabrication of polyurethane doors simulating wood comprises fabrication of a flexible mould on a selected prototype of grained wood. The door is fabricated on the mould and includes a structural element (5) embedded in the polyurethane. EMBODIMENT - The outside of the door is grained, matching the prototype.
Patent ES-2310144-A1 (ES)
Title: Intermediates for preparation of an inhibitor of phosphodiesterase type 5
Inventor: CANTOS LLOPAT CARME
IPC: C07F5/02
Filed: 2007-06-15
Abstract: Boronic compounds of formula II and the process for their preparation, wherein Y 1 and Y 2 are selected from hydroxyl, (C 1 -C 4 )alcoxyl and phenoxyl optionally substituted with one or two radicals independently selected from (C 1 -C 4 )alkyl and (C 1 -C 4 )alcoxyl or alternatively Y 1 and Y 2 together with the boron atom can form a cyclic system. Process for the preparation of Sildenafil by reaction of a intermediate of formula II with a intermediate of formula III, wherein X 3 is a leaving group and R 1 is selected from H and (C 1 -C 4 )alkyl.
Patent ES-2399036-A1 (ES)
Title: Heat exchanger for gas, in particular for the exhaust gas of an engine
Inventor: TOMAS HERRERO EVA
IPC: F02M25/07
Filed: 2010-06-28
Abstract: The exchanger (1) has a casing (2) for allowing circulation of exhaust gas to exchange heat with a coolant. A coupler (6) and a duct are connected to a coolant circuit and integrated to a gas reservoir forming piece (7) that is coupled with an end of the casing. The reservoir forming piece integrates a lug (9) fixed to an engine block, and another coupler (4) is coupled with an exhaust gas circuit. The reservoir forming piece is made from stainless steel or aluminum.
Patent ES-2369186-A1 (ES)
Title: Automatic olive classification system
Inventor: SANCHEZ SOLANA ANTONIO MIGUEL
IPC: A01D46/26
Filed: 2008-02-28
Abstract: The invention relates to a system that has been specially designed to be used in olive oil mills, said system comprising the use of a plurality of RFID tags (1-1') which can be placed among the olives or secured to the various trailers (2) used to transport same to the olive oil mill and which contain recorded information relating to the olive harvest type. Antennas (3) are provided at the oil mill entrance in order to read the tags which are associated with an information-storage and -management database (4), thereby identifying the type of olives entering the facility and assigning the corresponding trailer with the correct discharge hopper. The facility includes a series of collection hoppers (6-6'-6"-6''") having a second antenna (7) positioned nearby, for checking the container type. The invention is characterised in that when the tags (1-1') are mixed with the olives the outlets of the discharge hoppers (8-8'-8") of the olive containers (9) are provided with a series of conveyor belts (11-11'-11"), each having an associated read antenna (10) which is used to check the tag information relating to the olives and, upon detection of a tag that does not correspond to the allocated line, the system is stopped and switched to another belt (12), such that the belts (11-11'-12) are communicated respectively with the storage hoppers (13-13'-13") of each perfectly classified olive type, each having a corresponding production line (14-14'-14") at the outlet thereof.
Patent SG-119336-A1 (SG)
Title: Use of a chemically modified starch product
Inventor: BROWN IAN
IPC: A23L7/109
Filed: 2005-07-27
Abstract: The present invention relates to the use of a chemically modified starch to control and/or regulate the blood glucose level of mammals and post-prandial absorption. Such chemically modified starches, when properly formulated into foods, may be used to provide the consumer with glucose over an extended time period and more constant glucose levels.
Patent WO-2015154105-A1 (WO)
Title: Dispositif de détermination non invasive de la concentration de glucose dans un organisme humain
Inventor: MARGARYAN HAKOB
IPC: A61B3/10
Filed: 2014-04-18
Abstract: La présente invention concerne un équipement médical, en particulier, le développement d'un dispositif optique pour la détermination non invasive de la concentration de glucose dans un organisme humain, et qui peut être appliqué dans l'industrie des équipements médicaux. L'invention concerne un dispositif simple pour la détermination non invasive de la concentration de glucose, dans lequel seuls les éléments optiques sont utilisés. Le dispositif enregistre la modification du vecteur de polarisation du faisceau de lumière monochromatique (4) réfléchi par l'œil, et déterminée par la biréfringence de l'œil, qui est provoquée par la teneur en glucose dans un liquide oculaire. Des éléments optiques de nouvelle génération - réseau de diffraction de polarisation à cristaux liquides (6) et retardateur de phase à cristaux liquides (5) à symétrie axiale - sont utilisés dans le dispositif de l'invention, lesquels conduisent à une simplification de la détermination de l'angle de rotation du vecteur de polarisation de faisceau de lumière monochromatique et à l'amélioration de la précision. De plus, au lieu d'un faisceau de lumière polarisée linéairement, habituellement utilisé dans de tels dispositifs, le faisceau laser à semi-conducteur à polarisation arbitraire est utilisé.
Patent AR-023445-A1 (AR)
Title: Unidad purificadora y refrescante destinada a la suspension de un reborde de la taza de un inodoro
IPC: E03D9/03
Filed: 2000-04-11
Abstract: Una unidad purificadora y refrescante que tiene una finalidad doble de difundir una fragancia fresca en un cuarto de bano e introducir substancias activasen cada agua de lavado pasante, comprendiendo la unidad un soporte con elementos de suspension flexibles no plegables para suspender la unidad del reborde deuna taza de inodoro, un deposito para substancia activa, tal como un líquido que contenga agente purificador y refrescante de aire, conectado de formadesvinculable al soporte, y una masa porosa que está dispuesta en el soporte de modo que sea ubicada en una trayectoria del agua de lavado pasante, cuando launidad está suspendida del reborde de la taza de inodoro, comunicando dicha masa porosa con la sustancia activa contenida en el deposito. El soporte estáprovisto de una boquilla de conexion adecuada para conexion a una abertura de descarga del deposito, de modo que cuando la unidad está suspendida del borde dela taza de inodoro, la abertura de descarga esté dirigida hacia abajo,y con una parte de proyeccion de una longitud que sustancialmente se corresponde alancho de los elementos de suspension desplegados, más menos el espesor del casco de la taza de inodoro.
Patent AR-023838-A1 (AR)
Title: Procedimiento para cristalizar clorhidrato de (r)-fluoxetina
IPC: C07C213/10
Filed: 2000-05-03
Abstract: La presente se refiere a procedimientos para cristalizar clorhidrato de (R)-fluoxetina de formula (1).
Patent AR-029750-A1 (AR)
Title: Un procedimiento de polimerizacion de olefinas de fase gaseosa o de suspension, un metodo para producir una pelicula, un metodo para preparar un compuesto metalico y un aducto de metal, un producto de reaccion y una composicion de catalizador
IPC: C08F4/44
Filed: 2000-05-15
Abstract: Un procedimiento de polimerizacion que comprende combinar una olefina en la fase gaseosa o de suspension, con un activador, un soporte y un compuesto representado por la formula (1) donde: M es un grupo de 3 a 14 metales; cada X es independientemente un grupo anionico saliente; n es el estado de oxidacion de M; m es la carga formal del ligando YZL; Y es un grupo de 15 elementos; Z es un grupo de 15 elementos; L es un grupo de 15 a 16 elementos; R1 y R2 son independientemente un grupo hidrocarbonado C1-20, un heteroátomo que contiene un grupo silicio, germanio, estano, plomo, fosforo, halogeno; R1 y R2 pueden estar también interconectados entre sí; R3 está ausente o es hidrogeno, un grupo que contienen 14 átomos, un halogeno, un grupo que contiene un heteroátomo; R4 y R5 son independientemente un grupo arilo, un grupo arilo substituido, un grupo alquilo cíclico, un grupo alquilo cíclico substituido, o un sistema de multiples anillos; y R6 y R7 están independientemente ausentes o son hidrogeno, halogeno, heteroátomos o un grupo hidrocarbilo o un grupo que contiene un heteroátomo; un método para producir una película, un método para preparar un compuesto metálico y un aducto de metal, un producto de reaccion y una composicion de catalizador.