Patent CA-3090027-A1 (CA)
Title: Activatable antibodies and methods of making and using thereof
Inventor: LUO PETER PEIZHI
IPC: A61K39/395
Filed: 2019-02-02
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY  (PCT) (19) World Intellectual Property Organization International Bureau                             (10) International Publication Number (43) International Publication Date                WO 2019/149282 Al 08 August 2019 (08.08.2019)    WIPO I PCT (51) International Patent Classification:    TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, C07K 1,1/00 (2006.01)    A 61P 35/00 (2006.01)    KM, ML, MR, NE, SN, TD, TG). A 61K 39/395 (2006.01) Published: (21) International Application Number: .ti h PCT/CN2019/074581    nternational search report (Art. 21 (3)) ¨                                            with sequence listing part of description (Rule 5.2(a)) (22) International Filing Date: 02 February 2019 (02.02.2019) (25) Filing Language:                   English (26) Publication Language:              English (30) Priority Data:   02 February 2018 (02.02.2018) CN (71) Applicant: ADAGENE INC. [GB/GB]; Harbour Place, 103 South Church Street, P.O. Box 2582, Grand Cayman, KY1-1103 (KY). (72) Inventor; and (71) Applicant (fir MN only): LUO, Peter Peizhi [US/CNI;  4F, Building C14, 218 Xinghu St., Suzhou Industrial Park, Suzhou, Jiangsu 215123 (CN). = (72) Inventor: DU, Fangyong; C/o ADAGENE INC., 4F, Building C14, 218 Xinghu St., Suzhou Industrial Park, Suzhou, Jiangsu 215123 (CN). (74) Agent: WU, FENG & ZHANG; 3 FL, Building 2, Yard 3, FengXiuZhongLu Road, Haidian District, Beijing 100094 (CN). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CIL CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. ______________________________________  (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, IIR, HU, IE, IS, IT, LT, LU, LV, 44                                      MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, OC   71'  _________________________________________________________________________ (54) Title: ACTIVATABLE ANTIBODIES AND METHODS OF MAKING AND USING THEREOF (57) Abstract: Provided herein are libraries containing synthetic polynucleotides that encode activatable binding polypeptides. Further 0 provided herein are activatable binding polypeptides and polypeptide libraries containing such activatable binding polypeptides. Also " provided herein are vectors, vector libraries, cells, kits, and methods of making and using activatable polypeptide libraries.