baber/WOPTO huggingface dataset:
Patent DK-1257295-T3 (DK)
Inventor: BORNAES CLAUS
IPC: A61P31/04
Filed: 2001-02-12
Granted: 2009-08-10
Abstract: The present application relates to factor VII (FVII) or Factor VIIa (FVIIa) polypeptide conjugates, to their preparation and use in therapy, in particular for the treatment of a variety of coagulation-related disorders. These polypeptide conjugates comprise at least one non-polypeptide moiety covalently attached to a polypeptide, wherein the amino acid sequence of the polypeptide differs from that of wild-type FVII or FVIIa in that at least one amino acid residue comprising an attachment group for said non-polypeptide moiety has been introduced or removed. The conjugates of the present application have one or more improved properties as compared to commercially available rFVIIa, including increased functional in vivo half-life and/or increased plasma half-life, and/or increased bioavailability and/or reduced sensitivity to proteolytic degradation.
Patent DK-1313508-T3 (DK)
Inventor: NIYIKIZA CLET
IPC: A61K31/714
Filed: 2001-06-15
Granted: 2007-08-06
Abstract: A method of administering an antifolate to a mammal in need thereof, comprising administering an effective amount of said antifolate in combination with a methylmalonic acid lowering agent.
Patent DK-1230582-T3 (DK)
Inventor: SCHMIDT-SACHT WULF
IPC: G03D15/00
Filed: 2001-07-14
Granted: 2003-07-21
Abstract: The invention concerns a method of archiving and transmitting image data of a customer to a development laboratory (20), wherein the customer inputs the image data at an input device (1) and there selects at least one image product (15) to be produced by the development laboratory (20) as an order, from which order data are produced by the input device (1). In order in that respect to provide a possible way of archiving image data, it is provided in accordance with the invention that the image data and the order data of the customer after the selection of the at least one image product (15) are stored on a separate data carrier (9) and that on the basis of said data carrier (9) which is transmitted to the development laboratory (20) the at least one selected image product (15) is produced and delivered with the data carrier (9) to the customer. The invention also concerns a corresponding device and a corresponding data carrier for archiving and transmitting image data.
Patent DK-1379235-T3 (DK)
Inventor: THAKKER DHIREN R
IPC: A61P25/00
Filed: 2001-10-10
Granted: 2007-01-29
Abstract: Compositions and methods for enhancing paracellular permeability at an absorption site in a subject are disclosed. The method includes: (a) administering an effective amount of a phospholipase C inhibitor to a subject at a time in which enhanced paracellular permeability is desired; and (b) enhancing paracellular permeability in the subject at the absorption site through the administering of the effective amount of the phospholipase C inhibitor. The disclosed compositions and methods provide enhanced absorption of a hydrophilic drug in a subject.
Patent DK-1361815-T3 (DK)
Inventor: DYSON JAMES
IPC: B04C5/24
Filed: 2002-01-28
Granted: 2006-09-25
Abstract: A vacuum cleaner with an external surface incorporates a cyclonic separating apparatus that includes a plurality of cyclones arranged in parallel with one another. The cyclones each have a tapered body with an outside wall and are arranged so that at least a part of each outside wall forms part of the external surface of the vacuum cleaner.
Patent DK-1361890-T3 (DK)
Inventor: GARCON NATHALIE
IPC: A61K47/24
Filed: 2002-02-21
Granted: 2011-06-27
Abstract: The invention relates to the use of non-live influenza antigen preparations, particularly a split influenza preparation, in the manufacture of one-dose influenza vaccines for intradermal delivery.
Patent DK-1381611-T3 (DK)
Inventor: RONCUCCI GABRIO
IPC: A61P13/08
Filed: 2002-03-20
Granted: 2005-10-24
Abstract: Phthalocyanine analogues having an active group able to link the phthalocyanine t carriers molecules and phthalocyanine to carriers molecules and phthalocyanine analogues as phthalocyanine-carrier conjugates showing enhanced photodynamic properties, red shifted absorption characteristic, all useful for photodynamic therapy, are described. Photosensitizers themselves or the photosensitizers-carriers conjugates are useful compounds either for treatment of various infectious diseases, the in vivo eradication of micro-organisms as well as diseases characterized by cellular hyperproliferation, in particular tumours psoriasis, actinic keratosis, atheromas, endoarterial hyperplasia and prostate hyperplasia. The above compounds can be also useful for blood and blood derivatives sterilization and in vivo/vitro diagnostics.
Patent DK-1438053-T3 (DK)
Inventor: DAHMANN GEORG
IPC: C07D487/04
Filed: 2002-10-14
Granted: 2008-12-08
Abstract: 5-Substituted 2,4-diamino-pyrimidine derivatives (I) are new. Pyrimidines of formula (I) (including tautomers, racemates, enantiomers, diastereomers and their mixtures) and their acid addition salts are new. [Image] R aH or T; T : 1-4C alkyl; R b-T-Ar (optionally substituted (os)) or substituted phenyl; R a + R 1 (in the o-position to the N substituted by R a) : 2-4C n-alkylene (os by 1 or 2 T); R 5H, T (os by halo), Ar or -T-Ar; m, n : 1 - 3; or m : 0; and n : 2 - 4; NR cR doptionally substituted alkylene imino group, substituted 3-thiazolidino, optionally substituted pyrrolidino, optionally substituted piperidino, optionally substituted homopiperidino, azetidino (os by T) or an optionally substituted heterobicyclic group; or R cH, 1-8C alkyl, optionally substituted cycloalkyl, optionally substituted -T-(3-7C) cycloalkyl, optionally substituted -T-Ar, 3-5C alkenyl (os by Ar) or 3-5C alkynyl (os by Ar); and R dsubstituted 1-16C alkyl, substituted 4-7C cycloalkyl, dihaloaryl-(1-6C) alkyl (ring-substituted by OH or NH 2), 2- or 3-quinuclidinyl or -T-(2, 3 or 4)-quinuclidinyl; or R cH or T; and R dOH or OT; R ehalo, CN, NO 2, T, OT, NHT, NT 2, COT, ST, SOT, SO 2T, -T-OY, -T-N(T)COT, -T-NHCOT, -T-NHSO 2T, CONH 2, CONHT, CONT 2, -T-NH 2, -T-NHT or -T-NT 2; Me, OMe or SMe substituted by 1-3 F; T', OT' or ST' substituted by 1-5 F; (3-6C) cycloalkyl-(1-3) alkyl (os by 1-6 F); 2-5C alkenyl, 3-5C alkenyloxy, 2-6C alkynyl or 3-6C alkynyloxy (provided unsaturated carbons are not bonded to O); or 4-7 membered alkylene imino group or -T-(4-7 membered alkylene imino group) (os by 1-4 T), where in 6-7 membered AIM the CH 2 in the 4-position is optionally replaced by O, S, SO, SO 2, NH, NT, N-COT, N-SO 2T, NAr or N-T-Ar; T' : 2-4C alkyl; Ar : phenyl (optionally having 1 or 2 C replaced by N and os by up to 5 substituents); Provided that C-atoms of alkyl, alkylene or cycloalkylene moieties bonded to O, S or N are not bonded to a further halo, O, N or S (unless specifically stated otherwise). An independent claim is included for the preparation of (I). ACTIVITY : Virucide; Anti-HIV; Antibacterial; Fungicide; Antiparasitic; Dermatological; Antipsoriatic; Osteopathic; Cardiant; Vasotropic; Cytostatic; Immunosuppressive; Antiinflammatory; Antiarthritic; Neuroprotective; Nootropic; Nephrotropic; Vulnerary. MECHANISM OF ACTION : Protein-Kinase-Inhibitor; SRC-Kinase-Inhibitor; PLK-Kinase-Inhibitor; Aurora-Inhibitor-A; Cyclin-Dependent-Kinase-Inhibitor. 2-(2-Naphthylamino)-4-(3-(2-oxo-pyrrolidin-1-yl)-propylamino)-5-trifluoromethyl-pyrimidine (Ia) had an IC 5 0 value of below 100 nM for inhibition of CDK1/cyclin B1.
Patent DK-1474426-T3 (DK)
Inventor: WENSLOW ROBERT
IPC: C07D487/04
Filed: 2002-09-20
Granted: 2011-11-21
Abstract: The present invention relates to a process for reducing the levels of organic solvents to pharmaceutically acceptable levels in thermally unstable crystalline carbapenem solids represented by formula I: or a salt thereof, wherein R<SUB>1 </SUB>and R<SUB>2</SUB>, are the same or different, and are selected from H, alkyl, aryl, and heteroaryl, comprising washing a carbapenem solid containing organic solvent with an organic solvent containing water; and using vacuum and/or inert gas (hydrated or dry) at low temperature to produce a compound of formula I containing pharmaceutically acceptable levels of organic solvents, wherein the water content of the crystalline carbapenem solid, correcting for organic solvents, is maintained at about 13% to about 25% during the process.
Patent DK-1438146-T3 (DK)
Inventor: FERY PETER
IPC: B07C3/00
Filed: 2002-10-15
Granted: 2006-05-29
Abstract: The information processing method detects and analyses the graphic information on the postal item. The information is detected in several processing stations. The information is then transmitted to the image processing unit where it is processed. Preferably it is determined whether the detected information differs from expected graphic information. The items to be posted can then be sorted according to the information analysis. Independent claims also cover an apparatus for carrying out the method.
Patent DK-1389891-T3 (DK)
Inventor: NIEDERDRAENK TORSTEN DR
IPC: H04R25/00
Filed: 2003-07-30
Granted: 2009-03-23
Abstract: The device has a microphone (10) to acquire an acoustic input signal and to transduce it into an electrical signal. A signal processing and control unit (12) processes the electrical signal. A receiver (14A) transduces the electrical signal into an acoustic signal. An antenna coil (14B) is wound around the receiver or the microphone. The coil implements the wireless transmission of data.
Patent DK-1359357-T3 (DK)
Inventor: CHOPP JR JOSEPH A
IPC: B65D63/02
Filed: 2003-05-02
Granted: 2006-10-02
Abstract: A metal cable tie (22) is disclosed. The cable tie (22) includes an elongate metallic strap (28), a metallic locking head (24), and metallic roller means (32). The strap (28) has a first end and a second end opposite the first end. The head (24) is secured to the first end of the strap (28) for receiving the second end of the strap (28). The head (24) comprises a strap entry face (44), a strap exit face (46), and a strap-receiving aperture (48) extending therebetween. The head (24) further comprises a floor (50) and a roof (36) which diverge in the direction of the exit face (46). The metallic roller means (32) lockingly engages the strap (28), and the head (24) comprises retention means (52) disposed adjacent the exit face (46) for captively holding the roller means (32) within the head (24). The roller means (32) is movable between a threading position wherein the roller means (32) is disposed adjacent the exit face (46) and the retention means (52), and a locking position wherein the roller means (32) is closer the entry face (44). The ratio of the distance from a point along a ceiling to the centre of the roller means (32) in the threading position to the diameter of the roller means (32) is less than 1.7. <IMAGE>
Patent DK-1388867-T3 (DK)
Inventor: DAENEKAS FRANZ
IPC: H01B3/44
Filed: 2003-06-08
Granted: 2007-10-29
Abstract: Between the first inner layer (2a) (PE) and the second outer layer (2b) (ethylene copolymer) there is a third layer (2c) of bonding agent. This includes little or no filler. The third layer is less than 0.2 mm thick. The outer, highly-filled second layer is extruded onto the uncooled, still-hot third layer. The third layer, comprising a film of bonding agent, is applied onto the first layer. The cable is run into the film longitudinally, or wrapped by winding it on. The second layer is extruded over it. The bonding agent melts at 70-100[deg]C. An independent claim is included for the method of making the cable, by co-extrusion and over-extrusion.
Patent DK-1485495-T3 (DK)
Inventor: DONALDSON JENNIFER
IPC: C12P19/14
Filed: 2003-03-05
Granted: 2010-11-22
Abstract: The present invention pertains to a method of converting cellulose to glucose by treating a pretreated lignocellulosic substrate with an enzyme mixture comprising cellulase enzyme and endoglucanase core proteins, wherein the endoglucanase core proteins are present in the enzyme mixture at an amount relative to all endoglucanases from about 35 wt. % to about 100 wt. % and wherein the endoglucanase cellulase enzymes are present in the enzyme mixture at an amount relative to the amount of CBH and EG enzymes from about 2 wt. % to about 50 wt. %. The pretreated lignocellulosic substrate is selected from the group consisting of agricultural residues, residues after starch or sugar removal, dedicated ethanol crops, forestry products, and pulp and paper products, or combinations thereof.
Patent DK-1539352-T3 (DK)
Inventor: MASSARO PETER
IPC: G01N35/10
Filed: 2003-07-18
Granted: 2010-04-19
Abstract: A robotically manipulable sample handling tool, such as a colony picking head or robotic pipetting tool, includes needles arranged on the tool. Actuators are associated with each needle to control flow for the needle. A plurality of plungers are each associated with a needle, and movement of the plungers can actuate a corresponding needle. Each of the plungers has a passageway that may be opened or closed, e.g., to move the corresponding needle and/or draw fluid into/expel fluid from the needle when the plunger is moved in the tool body. The actuators are arranged so that plunger passageways may be individually controlled by a controller.
Patent DK-1578703-T3 (DK)
Inventor: GUINOT DOMINIQUE
IPC: C04B22/06
Filed: 2003-12-24
Granted: 2007-07-30
Abstract: The invention relates to a setting accelerator for a composition comprising Portland cement, in the form of a slurry comprising at least one calcium aluminate, 0.5 4%, preferably 0.6 2.3% of an aluminous cement setting inhibitor by weight in relation to the overall weight of the calcium alumnate, and an anti-sedimentation agent.
Patent DK-1614334-T3 (DK)
Inventor: WILLI AUF DER LANDWEHR
IPC: A01B29/04
Filed: 2004-12-09
Granted: 2008-07-14
Abstract: The roll for breaking up pieces of soil incorporates smooth rings (12) which are constituted as circumferential beads on a continuous carrier shaft (10) of rotatable working rings (16, 18).
Patent DK-1670729-T3 (DK)
Inventor: SIMONS DENNIS ROBERT
IPC: C03B37/014
Filed: 2004-10-05
Granted: 2011-08-29
Abstract: The present invention relates to a method for manufacturing a preform for optical fibers, wherein deposition of glass-forming compounds on the substrate takes place. The present invention furthermore relates to a method for manufacturing optical fibers, wherein one end of a solid preform is heated, after which an optical fiber is drawn from said heated end.
Patent DK-1647587-T3 (DK)
Inventor: RAMALINGAM BALASUBRAMANIAM
IPC: C09J175/04
Filed: 2005-10-05
Granted: 2009-01-12
Abstract: The curing rate of a two component laminating adhesive is effectively accelerated by incorporating in at least one component a microencapsulated catalyst. When the laminating adhesive is subjected to an effective amount of pressure (for example, the pressure applied when laminating flexible films together using nip rollers), the catalyst (which may be, for example, a dialkyl tin dicarboxylate) is released from encapsulation and is made available to catalyze the polyurethane-forming reaction between the isocyanate groups and the active hydrogen-functionalized groups in the adhesive mixture.
Patent DK-1814451-T3 (DK)
Inventor: KWEK TAI CHUAN ALFRED
IPC: A61B5/366
Filed: 2005-10-25
Granted: 2018-04-23
Abstract: There is provided a system, method and apparatus for detecting a cardiac event in a subject, including: at least one electrode attached to the subject for obtaining an electrocardiogram of the subject's heart; and means for determining a size of an area under a QRS complex of the electrocardiogram. The at least one electrode may be attached to the subject's skin or to the subject's heart. Preferably, the means for determining the size of the area under the QRS complex of the electrocardiogram is either visual or quantitative. The subject may be a human being or an animal. It is advantageous that the size of the area under the QRS complex of the electrocardiogram is directly proportional to the mass of viable myocardium in the subject's heart. The cardiac event that may be detected may be degenerative cardiomyopathy, acute myocardial infarction, arrhythmia, myocardial ischaemia, or compromised ventricular function.
Patent DK-1698226-T3 (DK)
Inventor: EHLERT HELMUT
IPC: A01K3/00
Filed: 2006-02-18
Granted: 2008-05-19
Abstract: Protective fence comprises an upper flange (3) bent from a guiding profile (1) below a determined radius. The fence is convex and has a shoulder piece (5) on one side of the guiding profile of the upper flange to interact with the upper flange of a further guiding profile. The joined profiles are connected together using screw elements to a post (6). Preferred Features: The shoulder piece consists of a straight bulge part and an inclined bulge part. A plastic cover is formed on the upper side of a lower flange (4).
Patent DK-2024610-T3 (DK)
Inventor: KALINA ALEXANDER I
IPC: F01K25/06
Filed: 2007-04-05
Granted: 2011-12-05
Abstract: A condensation system is disclosed where a multi-component fluid is condensed to form a condensate, a portion of which is sub-cooled and mixed with non-condensable vapor in the system to reduce the accumulation of non-condensable vapor and to improve the stability and efficiency of the condensation system.
Patent DK-2151133-T3 (DK)
Inventor: MURTAGH PADRAIG
IPC: H04W4/14
Filed: 2008-05-14
Granted: 2012-04-02
Abstract: A message service entity of a first mobile operator network receives an SMS message and inspects delivery trail information associated with the received message. The message service entity controls invocation of a message-handling service for the received message based on the inspected delivery trail information. The delivery trail information can be carried with the message and the step of inspecting delivery trail information associated with the received message can comprise inspecting the delivery trail information carried with the message. Alternatively, the message service entity stores delivery trail information for messages previously processed by the message service entity, and the step of inspecting delivery trail information associated with the received message comprises using an identifier in the received message, or derived from the received message, to access the stored delivery trail information.
Patent DK-2272362-T3 (DK)
Inventor: FEUCHT DIETER
IPC: B60K17/16
Filed: 2002-09-10
Granted: 2012-07-23
Abstract: Composition contains an active agent combination of at least one 1-(thienyl-3-yl-sulfonylamino-(thio)carbonyl)-1,2,4-triazoline-5-(4H) -(thi)one derivative (I) (A), at least one other specific herbicides (B) and optionally a safener (C). Composition contains an active agent combination of at least one 1-(thienyl-3-yl-sulfonylamino-(thio)carbonyl)-1,2,4-triazoline-5-(4H) -(thi)one derivative if formula (I) (A), at least one other specific herbicides (B) and optionally a safener (C). [Image] Q 1, Q 2O or S; R 1alkyl (optionally substituted (os) by CN, halo or OT); alkenyl or alkynyl (both os by CN or halo); cycloalkyl or cycloalkyl-(1-4C) alkyl (both os by CN, halo or T); aryl or aryl-(1-4C) alkyl (both os by NO 2, CN, halo, T or OT); or Het or Het-(1-4C) alkyl (both os by CN, halo or T); T : 1-4C alkyl; Het : heterocyclyl containing up to 6C plus 1-4 N and/or 1 or 2 O or S; R 2H, CN, NO 2 or halo; alkyl, alkoxy, alkoxycarbonyl, alkylthio, alkylsulfinyl or alkylsulfonyl (all os by CN, halo or OT); or alkenyl, alkynyl, alkenyloxy or alkynyloxy (all os by CN or halo); R 3H, OH, SH, NH 2, CN or halo; alkyl (os by F, Cl, Br, CN, OT, COT or COOT); alkenyl or alkynyl (both os by F, Cl and/or Br); alkoxy, alkylthio, alkylamino or alkylcarbonylamino (all os by F, Cl, CN, OT or COOT); 3-6C alkenyloxy, 3-6C alkynyloxy, 3-6C alkenyloxy, 3-6C alkynyloxy, 3-6C alkenylamino or 3-6C alkynylamino; NT 2; aziridino, pyrrolidino, piperidino or morpholino (all os by Me and/or Et); cycloalkyl, cycloalkenyl, cycloalkoxy, cycloalkylthio, cycloalkylamino, cycloalkyl-(1-4C) alkyl, cycloalkyl-(1-4C) alkoxy, cycloalkyl-(1-4C) alkylthio or cycloalkyl-(1-4C) alkylamino (all os by F, Cl, Br, CN and/or T); or aryl, aryl-(1-4C) alkyl, aryloxy, aryl-(1-4C) alkoxy, arylthio, aryl-(1-4C) alkylthio, arylamino or aryl-(1-4C) alkylamino (all os by F, Cl, Br, CN, NO 2, T, CF 3, OT and/or COOT); R 4H, OH, NH 2, CN or 2-10C alkylideneamino; alkyl (os by F, Cl, Br, CN, OT, COT or COOT); alkenyl or alkynyl (both os by F, Cl and/or Br); alkoxy, alkylamino or alkylcarbonylamino (all os by F, Cl, Br, CN, OT or COOT); 3-6C alkenyloxy; NT 2; cycloalkyl, cycloalkylamino or cycloalkyl-(1-4C) alkyl (all os by F, Cl, Br, CN and/or T); or aryl or aryl-(1-4C) alkyl (both os by F, Cl, Br, CN, NO 2, T, CF 3 and/or OT); or R 3 + R 4optionally branched 3-6C alkanediyl; unless specified otherwise alkyl moieties have 1-6C, alkenyl or alkynyl moieties 2-6C, cycloalkyl or cycloalkenyl moieties 3-6C and aryl moieties 6-10C. - ACTIVITY : Herbicide; Defoliant. In post-emergence tests against Chenopodium album, the herbicidal rating was 70% for 8 g/ha of 1-(4-methoxycarbonyl-2-methyl-thienyl-3-yl-sulfonylaminocarbonyl)-3-m ethoxy-4-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazole (Ia), 80% for 250 g/ha of bromoxynil (B') and 100% (compared with a predicted value of 94%) for a combination of 8 g/ha of (Ia) and 250 g/ha of (B'). - MECHANISM OF ACTION : None given.
Patent DK-2931710-T3 (DK)
Inventor: FARNABY WILLIAM
IPC: C07D237/22
Filed: 2013-12-17
Granted: 2018-03-26
Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
Patent DK-3074707-T3 (DK)
Inventor: JO CARDOSO ENRIQUE
IPC: F26B5/06
Filed: 2014-11-26
Granted: 2018-04-16
Abstract: Method for controlling the quality of a freeze-drying process includes the steps of defining a set of experiments by statistical design of experiments; performing freeze-drying processes of a product for each one of the experiments; obtaining a dataset of pressures and temperatures from the freeze dryer, the dataset comprising at least one combined parameter; removing noise intrinsic to the measurements; performing a PCA to obtain a fingerprint of the lyophilization process for each one of the experiments; and selecting a range of fingerprints in which a specific product batch will be within specifications. Also provided is a process for controlling the quality of a freeze-drying process which comprises: performing the freeze-drying process at the temperature and pressure set points of the optimal process; obtaining a fingerprint of the process; and using the range of fingerprints obtained above to assess whether the product batch is within specifications.
Patent DK-0399866-T3 (DK)
Inventor: SCHIRMANN JEAN-PIERRE
IPC: C07C249/16
Filed: 1990-05-09
Granted: 1995-06-26
Abstract: Continuous process for the synthesis of azines from aqueous hydrogen peroxide, ammonia and a reactant containing a CO group, (i) a working solution circulating in a loop between the azine reactor and a treatment device and (ii) the introduction of a product preferably chosen from acetic acid, ammonium acetate and acetonitrile. The azines are hydrolysed to obtain hydrazine hydrate.
Patent DK-0437143-T3 (DK)
Inventor: PERCHERON JEAN-CLAUDE
IPC: E01D19/14
Filed: 1990-12-26
Granted: 1994-04-25
Abstract: In a cable-stayed bridge comprising a deck (1), at least one concrete pillar (2) and cables (3) in inverted V formation comprising multiple strands (4) each resting on a saddle (5), the strands extend individually from one foot to the other of the inverted V and there is provided, in order to maintain each strand under tension, on the one hand, two end anchoring devices (7,8), disposed at the two lower ends of the strand and each capable of anchoring one of these ends in the deck and, on the other hand, two intermediate anchoring devices (9, 10) traversed by the strand and respectively bearing on the two opposing vertical faces (F, G) of the pillar, these latter devices being arranged in such a way as to maintain the curved section of strand which rests on the saddle in its state of maximum tension.