baber/WOPTO huggingface dataset:
Patent IT-MI952517-A1 (IT)
Title: Dispositivo elettroluminescente a supporto flessibile migliorato e  procedimento per realizzare tale dispositivo
Inventor: ANTONINI LIVIO
IPC: H05B/
Filed: 1995-11-30
Abstract: Viene descritto un dispositivo elettroluminescente (10), sostanzialmente sottile, flessibile e pieghevole, comprendente un primo strato (11) di pellicola di materiale plastico, avente funzioni di substrato, un secondo strato (14) di materiale conduttore trasparente, avente funzioni di primo elettrodo, un terzo strato (15) costituito da materiale elettroluminescente disperso in matrice polimerica, un quarto strato (16) di materiale ceramico disperso in matrice polimerica, un quinto strato (13) di materiale conduttore, avente funzioni di secondo elettrodo ed un sesto strato (17) di materiale plastico, avente funzioni protettive e di rivestimento.Il dispositivo (10), realizzato secondo l'invenzione, presenta caratteristiche migliorative, rispetto allo stato dell'aria, quali un'elevata semplicità di lavorazione, con conseguente riduzione dei costi, migliori prestazioni meccaniche ed elettriche.
Patent IT-MI960244-A1 (IT)
Title: Derivati di 1-/e-(vinilsostituite)/-5h-2,3-benzodiazepine
Inventor: VAGO' PAL
IPC: C07D/
Filed: 1996-02-09
Abstract: La presente invenzione riguarda originali derivati delle 1-[2-(vinilsostituite)]-5H-2, 3-benzodiazepine, un procedimento per la loro preparazione, composizioni farmaceutiche che li comprendono, l'impiego di detti derivati benzodiazepinici per il trattamento di malattie e per la preparazione di composizioni farmaceutiche adatte per il trattamento di malattie.I composti secondo la presente invenzione corrispondono alla formula generale (I), in cui A e B assieme formano un gruppo =C=N- o =CH-NH-; R1 rappresenta fenile facoltativamente portante due o tre idrossigruppi oppure da uno a tre sostituenti identici o differenti scelti dal gruppo consistente in alogeno, trifluorometile, nitro, ciano, amino, C1-3, alchilamino, di-(C1-3 alchil)-amino, C1-4, alcanoilamino, C1-4 alchile, C1-4 alcossi, carbossi, (C1-4 alcossi)-carbonile, C1-4 alcossi carbonilossi e metilendiossi; naftile facoltativamente portante un sostituente scelto dal gruppo consistente in idrossi, C1-4 alcossi e C1-4 acilossi; furile, tienile od indolile; R1 sta per idrogeno o C1-4 alchile; R3 ed R4 sono indipendentemente C1-4 alcossi attaccati alle posizioni 7 ed 8 dell'anello benzodiazepinico, oppure R1 ed R4 assieme formano un gruppo 7, 8 od 8, 9-metilendiossi, e posseggono valide attività sul sistema nervoso centrale.
Patent IT-MI972806-A1 (IT)
Inventor: NAPOLETANO MAURO
IPC: A61K31/502
Filed: 1997-12-19
Abstract: A process for preparing a compound of formula I: wherein G is methylene, ethylene, CONH, amino or a bond; R is H, phenyl or a (C1-4)alkyl group optionally substituted by phenyl; Cy is phenyl or a 5- or 6-membered heterocycle of the group consisting of pyrrole, imidazole, pyrazole, pyrrolidine, pyrroline, imidazoline, imidazolidine, pyrazolidine, pyrazoline, pyridine, pyrazine, pyrimidine, pyridazine, piperazine, piperidine, and triazine, the Cy residue being optionally substituted by one or more substituent(s) selected from the group consisting of keto, nitro, carboxy, fluorine, chlorine, bromine, or iodine; R1 is a (C1-6)alkyl or polyfluoro(C1-6)alkyl group; and R2 is aryl, aryl-(C1-10)-alkyl, (C4-7)cycloalkyl or (C4-7)heterocycle wherein the heteroatom is an oxygen atom.
Patent IT-MI991083-A1 (IT)
Inventor: MORONE ALFIO
IPC: F16D13/68
Filed: 1999-05-18
Abstract: Clutch comprising a housing (10) connected to a driving shaft and provided with axial seats (11) for coupling to the outer toothing (31) of friction plates (30), a hub (40; 140; 240) solidary with a driven shaft (50, 51) and provided with radial means (41; 141; 241) of coupling to corresponding means (31; 80; 280) for transmitting the motion to plates (30) provided with internal toothing (31) for coupling to the said transmission means, and means (70; 71; 72; 73) for pushing the plates (20, 30) in the axial direction, the clutch comprising means (11; 80; 81; 280; 281) of helical shape for the transmission of the motion between the housing (10) and the hub (40; 140; 240). <IMAGE>   <IMAGE>
Patent IT-PI940019-A1 (IT)
Title: Sistema per la copertura esterna del parabrezza e del tettino di  un'auto e per la loro protezione dal gelo e/o dal sole.
Inventor: BENINCASA MAURO
Filed: 1994-07-05
Abstract: Trattasi di un sistema per la protezione esterna dei vetri, anteriore e posteriore, e del tettino dell'auto, costituito da un sistema di canalette contenenti dei teli riavvolti al loro interno e che, una volta distesi, vanno a proteggere le parti desiderate. Detto sistema consente di poter coprire i vetri ed il tettino dell'auto in modo semplice e rapido, con una facile operazione che consiste nello stendere i teli sulla superficie da proteggere fermando i relativi agganci nei punti prestabiliti.Il sistema in oggetto ha il vantaggio di essere di facile applicazione, fisso ma amovibile, e di rapida utilizzazione.Il suo scopo è di proteggere i vetri dal gelo e/o dal sole e da tutto ciò che potrebbe sporcarli cadendovi sopra.
Patent IT-RE950043-A1 (IT)
Inventor: MARCHESI FERNANDO
IPC: F24F1/02
Filed: 1995-07-27
Abstract: Internal air-conditioning unit (1) to be installed at the top of a wall (7), in which suction of the air (A) introduced in the room is performed in the top part of the casing, the evaporation set being provided in the vicinity of the rear wall thereof. The invention solves the problem of introducing into the room fresh external air (E), without having to use other external air-driving means.
Patent NO-20171272-A1 (NO)
Inventor: BARDEN ANDREW
IPC: F16L55/46
Filed: 2017-08-01
Abstract: Methods of remotely facilitating the transition between flooding and hydrotesting a Subsea pipeline include a control unit of a subsea valve actuation system closing off fluid flow out of the pipeline at the receiving end thereof based at least partially upon one or more signals emitted by at least one intelligent pig that has passed through the pipeline during flooding and without the involvement of an external source at the surface, or a UV, at the pig receiving end of the pipeline.
Patent NO-20180800-A1 (NO)
Inventor: RAVI KRISHNA
IPC: E21B47/12
Filed: 2018-06-08
Abstract: A disclosed subsurface detection system includes a first communication Device positioned in a borehole and configured to scan a plurality of frequencies in at least a portion of an annulus surrounding an exterior of a tubing including the casing string in the borehole or an interior of the tubing including the casing string. The plurality of frequencies include a first frequency corresponding to a first type of RFID tag and a second frequency corresponding to a second type of RFID tag. The first communication device is further configured to detecta response to the scan from an RFID tag of the first type or the second type in the portion of the annulus or the interior of the tubing. The system further includes a processor configured to receive communication of the detected response from the first communication device, and based on the detected response, determine one or more characteristics of an environment around the corresponding RFID a tag (e.g. an intrinsic impedance of a fluid material in the environment).
Patent PE-20001258-A1 (PE)
Title: Poliacrilamidas glioxalatadas como agentes fortalecedores de papel
Inventor: BOONE STEVEN R
IPC: D21H21/28
Filed: 1999-11-24
Abstract: SE REFIERE A UN METODO DE ELABORAR PRODUCTO DE PAPEL QUE COMPRENDA AGREGAR A LA PULPA HUMEDA: a) UNA POLIACRILAMIDA GLIOXALATADA, TAL COMO POLIACRILAMIDA CATIONICA, ANIONICA O ANFOTERICA GLIOXALATADA; Y b) UN OPACIFICADOR, TAL COMO ARCILLA, CARBONATO DE CALCIO PRECIPITADO, TiO2 Y SILICATO DE ALUMINIO. ASI SE FORMA UNA MEZCLA DE PULPA HUMEDA Y UN PRODUCTO DE PAPEL DE LA MEZCLA DE PULPA HUMEDA. SE PUEDE ELABORAR UN PRODUCTO DE PAPEL, PAPEL PERIODICO O PAPEL QUE CONTIENE MADERA CON UNA OPACIDAD DE POR LO MENOS 85%
Patent PE-20001103-A1 (PE)
Title: Procedimiento para producir un liquido presurizado con alto contenido de metano, a partir de un gas con alto contenido de metano
Inventor: STONE JOHN B
IPC: C10L3/06
Filed: 1999-12-16
Abstract: QUE COMPRENDE: 1) UNA PRIMERA ETAPA QUE CONSISTE EN EL SUMINISTRO DE UN LIQUIDO CON ALTO CONTENIDO DE METANO; 2) EL SUMINISTRO DE UN GAS PRESURIZADO CON ALTO CONTENIDO DE METANO, EL CUAL ES ENFRIADO PARA LUEGO INTRODUCIRLO EN EL LIQUIDO PRESURIZADO CON ALTO CONTENIDO DE METANO A UNA VELOCIDAD TAL QUE PRODUCE UNA CORRIENTE LIQUIDA CON ALTO CONTENIDO DE METANO. EL LIQUIDO PRESURIZADO CON ALTO CONTENIDO DE METANO Y EL GAS PRESURIZADO CON ALTO CONTENIDO DE METANO SE PASAN A TRAVES DE UN TERMOPERMUTADOR PARA CALENTAR EL LIQUIDO PRESURIZADO Y A SU VEZ ENFRIAR EL GAS PRESURIZADO; 3) LA ELIMINACION EN UNA ETAPA DE PRETRATAMIENTO, DE AQUELLOS COMPONENTES GASEOSOS EN EL GAS PRESURIZADO QUE PODRIAN FORMAR SOLIDOS A LA TEMPERATURA DE LA CORRIENTE DEL PRODUCTO LIQUIDO QUE ESTA SOBRE -112°C Y UNA PRESION NO MAYOR QUE LA DE SU PUNTO DE BURBUJEO; Y 4) LA CORRIENTE DE PRODUCTO PRESURIZADO CON ALTO CONTENIDO DE METANO ES CONDUCIDA A UN SEPARADOR DE FASE PARA PRODUCIR UNA CORRIENTE GASEOSA Y UNA CORRIENTE LIQUIDA, DICHA CORRIENTE LIQUIDA ES CONDUCIDA HACIA UN DISPOSITIVO DE ALMACENAMIENTO, EN EL CUAL EL LIQUIDO SE CONSERVA A UNA TEMPERATURA SOBRE -112°C Y A UNA PRESION QUE ES ESENCIALMENTE LA DE SU PUNTO DE EBULLICION
Patent PL-216660-A1 (PL)
IPC: B25B11/02
Filed: 1979-06-25
Abstract: In the manufacture of frames, particularly wooden frames, the glued faces have to be pressed together along the bevelled cuts. For this purpose a clamping frame is suggested which comprises a closed rectangular clamping frame consisting of a first frame portion (10) consisting of two limbs (10a, 10b) at right-angles to each other and a second frame portion (16) consisting of two limbs (16a, 16b) at right-angles to each other. The second frame portion (16) is displaceable relatively to the first frame portion (10) and the limbs (16a, 16b) of the second frame portion (16) project outwardly beyond the limbs (10a, 10b) of the first frame portion (10). On the outside of the limbs (10a, 10b) of the first frame portion and parallel thereto there are pull rods (18) which intersect at the corner of the first frame portion (10) and engage the projecting limb sections of the second frame portion (16). Clamps (22) can be applied to the sections of the limbs of the second frame portion (16) that project beyond the limbs of the first frame portion (10) as well as to the pull rods (18), which clamps are supported on the outside of the limbs of the first frame portion (10) and with which the second frame portion (16) can be tightened to the first frame portion (10). By means of such a clamping frame, frames of different size can be clamped simply and conveniently.
Patent PL-246384-A1 (PL)
Title: Method of obtaining new substituted quanidinoheterocyclophenyloamidines
IPC: C07D263/48
Filed: 1983-03-23
Abstract: The object of the present invention are new pharmacologically active substituted guanidino heterocyclicphenylamidines of the following formula 
<CHEM>
 in which R, R1 and R2 which may be the same or different, each represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, R3 represents a linear or branched alkyl group containing optionally heteroatoms such as oxygen, sulfur or nitrogen atom, a linear or branched alkenyl group, an alkynyl group, a cyano group, a cycloalkyl or cycloaliphatic alkyl group, a bicyclic group, an aryl group, a heterocyclic group or R3 and R2 together with the adiacent nitrogen atom represent a heterocyclic group, R4 represents a hydrogen atom, an alkyl or alkoxy group having 1 to 4 carbon atoms or a halogen atom, Het represents a substituted or unsubstituted heterocyclic group containing two or three heteroatoms and tautomers thereof and acid addition salts of the aforesaid compound. Processes for the preparation of the compounds of formula (I) as well as pharmaceutical compositions containing them are also object of this invention. The new compounds are H2- receptor blocking agents which inhibit gastric acid secretion, and are useful antiulcer agents.
Patent PL-301534-A1 (PL)
Title: Fixing device
Inventor: HOFLE SIEGFRIED
IPC: F16B37/04
Filed: 1993-12-17
Abstract: The fastening device serves to fit components on a fastening rail (32) which exhibits a slot-like opening (34). For better handling, the fastening device exhibits a spring element (27) which can be sprung in both the axial and the radial directions. By virtue of an outer contour of a region (31) which can be sprung radially in a compressed manner and is larger than a width of the slot-like opening (34), a snap-like fixing of the fastening device on the fastening rail (32) is achieved. The axially elastic region (28) of the spring element (27) produces axial bracing between the basic body (21) and the intermediate body (29). <IMAGE>
Patent PL-313622-A1 (PL)
Title: Novel urethane containing aminosteroid compounds
Inventor: YU CHIA-NIEN
IPC: A61P9/00
Filed: 1994-09-23
Abstract: Urethane-containing amino steroids having the general chemical formula: wherein a, b, R1, R2, R3, R4, R14 and Z are as defined in the specification. Also disclosed are pharmaceutical composition and the use of the compounds/composition in the treatment of congestive heart failure.
Patent PL-318215-A1 (PL)
Title: Method of and apparatus for obtaining foamed fibre or paper fabric
Inventor: REINER LENNART
IPC: D21F11/00
Filed: 1995-07-12
Abstract: PCT No. PCT/SE93/00848 Sec. 371 Date Jan. 15, 1997 Sec. 102(e) Date Jan. 15, 1997 PCT Filed Jul. 12, 1995 PCT Pub. No. WO96/02702 PCT Pub. Date Feb. 1, 1996Method of producing a foam-formed fibre or paper web, whereby a foamed fibre dispersion is formed by dispersing natural and/or synthetic fibres in a foamable liquid comprising water and a tenside in a dispersion vessel (111) and by conveying the foamed fibre dispersion to a wire (118) on a paper machine. The foamed liquid which is removed through the wire (118) is conveyed to a closed foam tank (128) in which a draining of the liquid to the bottom of the tank occurs, whilst the lighter foam is collected in the top of the foam tank. Liquid from the bottom of the foam tank is led to the dispersion vessel (111) via a first pipeline (129), whilst foam passes to the dispersion vessel via a second pipeline (130) in the top of the foam tank where the fibres are added and dispersed in the foamable liquid.
Patent PL-322379-A1 (PL)
Title: Method of producing a web of material
Inventor: GASS MICHAEL DR-ING
IPC: D21F1/00
Filed: 1997-01-17
Abstract: A process for manufacture of a web of material (1) entails producing a plastic layer (5, 6) on at least one side of a carrier (2) from a mixture of plastic material and granular soluble pieces, and afterwards dissolving out at least some of the pieces by a solvent against which the plastic is resistant while forming permeable channels. Plastic powder is prepared, mixed with the small soluble pieces and applied to the carrier. The plastic layer (5, 6) is formed from the mixture by heat and pressure treatment before dissolving at least some of the pieces.
Patent PL-322735-A1 (PL)
Title: Fence post
Inventor: LECHTENBOEHMER HANS NORBERT
IPC: E04H17/16
Filed: 1996-04-10
Abstract: PCT No. PCT/DE96/00624 Sec. 371 Date Oct. 14, 1997 Sec. 102(e) Date Oct. 14, 1997 PCT Filed Apr. 10, 1996 PCT Pub. No. WO96/33327 PCT Pub. Date Oct. 24, 1996Fence post (50) of a fence (100) of grid boards (20) comprising narrow, upright grid boards with upright rods (11, 12) and brackets (10) connecting these rods, which brackets project over the front side (13) of the fence post (50) with their free ends (3'). The grid boards (20) lie with horizontal rods (2, 2) on the projecting ends (3'). The projecting ends (3') form retaining elements (3) in the form of hooks that fasten the grid boards (20) at the front side (13) of the fence posts (50).
Patent PL-329551-A1 (PL)
Title: Method of conducting an intermolecular etherification and etherolysis processes
Inventor: MORAWIETZ MARCUS
IPC: C07C29/10
Filed: 1998-11-05
Abstract: Intermolecular etherification of mono- or multivalent alcohols is carried out in the presence of an additional acid-stable hydrogenation catalyst in a hydrogen atmosphere. Process for the intermolecular etherification of mono- or multivalent alcohols and ether splitting comprises treating the alcohol in the case of etherification or the ether in the case of ether splitting in the aqueous phase in the presence of an acid catalyst at at least 100 degrees C and then treatment is carried out using an acid-stable hydrogenation catalyst in a hydrogen atmosphere.
Patent PL-337508-A1 (PL)
Title: Laundry washing method
Inventor: MERZ THOMAS
IPC: C11D3/08
Filed: 1998-06-12
Abstract: A process for washing laundry is provided in which a washing alkali component and a surfactant component are combined with water to form a wash liquor, the wash liquor is combined with laundry in a standard washing machine for institutional laundries, and the wastewater from the wash is treated by membrane filtration, where the throughflow rate is reduced by less than 10 percent over an operating time of 120 hours. The washing alkali component is composed of an anionic surfactant and a water-soluble silicate; an alkali metal hydroxide and a complexing agent; or an anionic surfactant and water-soluble silicate and an alkali metal hydroxide, a complexing agent, or a mixture of an alkali metal hydroxide and a complexing agent. The surfactant component is composed of a nonionic surfactant selected from the group consisting of C8-18 fatty alcohol alkoxylates containing at least 5 alkoxy groups, C8-18 fatty alcohol ethoxylates containing at least 7 ethoxy groups, C8-18 fatty alcohol ethoxylate/propoxylates containing at least 4 ethoxy groups and at least 2 propoxy groups in the molecule, and mixtures thereof.
Patent PL-345689-A1 (PL)
Title: Skin and tissue care and/or treatment agent
Inventor: SCHLACHTER HERBERT
IPC: A23L1/304
Filed: 1999-07-15
Abstract: A composition (I) containing (a) at least one salt selected from alkali metal salts, alkaline earth metal salts and other minerals, additionally contains (b) at least one aminoacid and (c) zinc oxide and/or an inorganic peroxide. ACTIVITY : Dermatological; antipsoriatic; antirheumatic; cytostatic; gastrointestinal. MECHANISM OF ACTION : (I) promotes diffusion of ions through ion channels into the intracellular space to improve microcirculation.
Patent PL-350769-A1 (PL)
Title: Substituted aniline compounds
Inventor: HAMPRECHT GERHARD
IPC: C07C229/56
Filed: 2000-03-31
Abstract: The present invention relates to substituted aniline compounds of the formula 1in which R<21>, R<22 >and R<23 >have the meanings indicated in the description. The compounds according to the invention are intermediates for the preparation of herbicidally active pyridinedicarboxamide compounds.
Patent PL-353952-A1 (PL)
Title: 1,4-dioxacycloalkane-2-one and 1,4-dioxacycloalkene-2-one
Inventor: EH MARCUS
IPC: C11B9/00
Filed: 2000-09-14
Abstract: The present invention relates to novel macrocyclic compounds, and to their preparation and use in perfumes. Specifically, the present invention relates to novel 1,4-dioxacycloalkan-2ones and 1,4-dioxzcycloaken-2-ones.
Patent PL-361357-A1 (PL)
Title: Double-rotatable spindle head for machine tools
Inventor: PICCOLO GABRIELE
IPC: B23Q1/54
Filed: 2001-04-11
Abstract: A double rotatable spindle head of non-perpendicular axis type has a first half head and a second half head. The first half head is connected to the machine structure and rotates about a first axis. The second half head is coupled to the first half head on a flat surface and rotates about a second axis perpendicular to the flat surface. The rotation of the first and second half heads is achieved by a first and second direct motor, respectively.
Patent PL-362482-A1 (PL)
Title: An emanator device
Inventor: JONES STUART MICHAEL RUAN
IPC: A61L9/12
Filed: 2001-10-19
Abstract: An emanator for emanating a composition into its surroundings, the emanator comprising: a container for containing a volatile liquid comprising a composition to be emanated; an emanation surface from which the volatile liquid evaporates; a wick for transporting the volatile liquid from the container to the emanation surface, characterized in that the transport of the liquid through both the wick and the emanator occurs at the surface of both the wick and the emanator and in that transport of the liquid through the wick occurs only at the surface of the wick by capillary action. In a preferred embodiment the wick and the emanation system are integrally formed from a material formed with microgrooves.
Patent PL-362803-A1 (PL)
Title: Novel method and compositions for local treatment of meniere's disease, tinnitus and/or hearing loss
Inventor: RASK-ANDERSEN HELGE
IPC: A61K31/5575
Filed: 2002-01-15
Abstract: A novel method and compositions for the local treatment of Meniere's disease, tinnitus and hearing loss are described. The treatment is based on the administration of a therapeutically effective amount of a prostaglandin of the F-type to the inner ear. The treatment can be either continuous or intermittent and may involve the use of pumps, gels, or slow release drug inserts.
Patent PL-363081-A1 (PL)
Title: Growth hormone secretagogues
Inventor: MARTINEZ JEAN
IPC: A61P3/02
Filed: 2001-06-13
Abstract: The invention relates to compounds of formula I which are useful for elevating the plasma level of growth hormone in a mammal as well as for the treatment of growth hormone secretion deficiency, growth retardation in child and metabolic disorders associated with growth hormone secretion deficiency.
Patent PL-372568-A1 (PL)
Title: Barrier laminate structure for packaging beverages
Inventor: CLEVELAND CHRISTOPHER S
IPC: B32B27/10
Filed: 2003-05-02
Abstract: A barrier laminate packaging material comprising from its outermost surface to the innermost surface contacting the contents of the container to be prepared therefrom, a first exterior layer of a low density polyethylene polymer, a paperboard substrate, a first interior layer laminate coating of nylon with a tie resin layer, a blown film layer comprising a first low density polyethylene polymer layer, a tie layer, a first interior layer of EVOH, a second tie layer, a second interior layer of EVOH, a third tie layer and a second interior layer of low density polyethylene polymer, and an innermost product contacting layer of low density polyethylene.
Patent PL-377732-A1 (PL)
Title: New synergistic combination comprising roflumilast and formoterol
Inventor: BEUME ROLF
IPC: A61K31/44
Filed: 2003-11-26
Abstract: The invention relates to the combined administration of roflumilast and formoterol for the treatment of respiratory tract disorders.
Patent PL-399352-A1 (PL)
Title: Methods for producing hyalouronan in the host recombinant cell
Inventor: SLOMA ALAN
IPC: C12N15/52
Filed: 2002-12-20
Abstract: The present invention relates to methods for producing a hyaluronic acid, comprising: (a) cultivating a Bacillus host cell under conditions suitable for production of the hyaluronic acid, wherein the Bacillus host cell comprises a nucleic acid construct comprising a hyaluronan synthase encoding sequence operably linked to a promoter sequence foreign to the hyaluronan synthase encoding sequence; and (b) recovering the hyaluronic acid from the cultivation medium. The present invention also relates to an isolated nucleic acid sequence encoding a hyaluronan synthase operon comprising a hyaluronan synthase gene and a UDP-glucose 6-dehydrogenase gene, and optionally one or more genes selected from the group consisting of a UDP-glucose pyrophosphorylase gene, UDP-N-acetylglucosamine pyrophosphorylase gene, and glucose-6-phosphate isomerase gene. The present invention also relates to isolated nucleic acid sequences encoding a UDP-glucose 6-dehydrogenase, UDP-glucose pyrophosphorylase, and UDP-N-acetylglucosamine pyrophosphorylase