baber/WOPTO huggingface dataset:
Patent AU-2003282877-B9 (AU)
Title: In Vivo gene silencing by chemically modified and stable siRNA
Inventor: RANA TARIQ M
IPC: C12N15/113
Filed: 2003-09-25
Granted: 2011-05-12
Abstract: The present invention provides compositions for RNA interference and methods of use thereof. In particular, the invention provides small interfering RNAs (siRNAs) having modification that enhance the stability of the siRNA without a concomitant loss in the ability of the siRNA to participate in RNA interference (RNAi). The invention also provides siRNAs having modification that increase targeting efficiency. Modifications include chemical crosslinking between the two complementary strands of an siRNA and chemical modification of a 3′ terminus of a strand of an siRNA. Preferred modifications are internal modifications, for example, sugar modification, nucleobase modification and/or backbone modifications. Such modifications are also useful, e.g., to improve uptake of the siRNA by a cell. Functional and genomic and proteomic methods are featured. Therapeutic methods are also featured.
Patent AU-2015334886-B9 (AU)
Title: Treatment of cancers using anti-NKG2A agents
Inventor: ANDRE PASCALE
IPC: A61P35/00
Filed: 2015-10-23
Granted: 2021-07-08
Abstract: The present disclosure relates to HLA-E as a tumor escape mechanism in head and neck cancer. The disclosure relates to methods for the treatment of head and neck cancer, notably HLA-E expressing head and neck squamous cell carcinoma, using antibodies that specifically bind and inhibit human NKG2A.
Patent DE-3232161-C1 (DE)
Title: Cutting device
IPC: B26B5/00
Filed: 1982-08-30
Granted: 1984-03-15
Abstract: A cutting device comprises a housing, in which a lever is centrically mounted, which lever carries a cutting blade at one free end. The lever is under the pressure of a spring which guides the blade into the housing. To exchange the blade simply and safely, mutually opposite openings are provided in the housing in the region of the pin-shaped blade fixtures. The lever is permanently mounted inside the housing.
Patent DE-3525153-C1 (DE)
Title: Measuring mandrel arrangement for an inductive sensor for determining the wall thickness of plastics pipes during extrusion
Inventor: MUELLER GUENTER
IPC: B29C48/92
Filed: 1985-07-13
Granted: 1986-09-11
Abstract: A measuring mandrel arrangement for an inductive sensor for determining the wall thickness of plastics pipes during extrusion is described, which sensor consists of a plurality of iron bars connected movably to one another and lying one behind the other and of a measuring mandrel connected to the iron bars so as to be movable over a relatively large distance by means of a non-magnetic material. The iron bars are hollow in design and fastened on a continuous flexible non-magnetic core which bears at a relatively large distance from the iron bars an end piece made of non-magnetic material on which the measuring mandrel is fastened by means of a swivel. In order to improve the sliding behaviour, the transitions between the iron bars or the end piece and the continuous flexible core are designed as a constant taper. The swivel serves as a fulcrum and permits a rotation or movement of the measuring mandrel with respect to the end piece. The core used is preferably a mixed fibre core, for example of a polyamide-cotton multifilament, on which the iron mandrels and the end piece are fastened by means of a flexible adhesive.
Patent DE-3535114-C1 (DE)
Title: Photographic bust
Inventor: SCHUHR WALTER DR-ING
IPC: B44F7/00
Filed: 1985-10-02
Granted: 1987-04-23
Abstract: Coloured transparent stereoscopic images with or without glass frames are to be cast together with simple stereoscopes (see drawing) or reflective stereoscopes into an independent transparent block or are alternatively to decorate a wall, such as a "celebrities gallery". This latter situation, in particular, justifies the use of the term "photographic bust". Additional applications, such as constructing a "memorial" (photographic bust) for anyone during his lifetime in the memorial or stonemasonry trade or even decorating gravestones, and in the interior decoration of houses, rooms and flats, are quite impossible to predict in their entirety as yet.
Patent DE-3535773-C1 (DE)
Title: Method for producing rigid-flexible multilayer circuits
Inventor: GRANDL HEINZ
IPC: H05K3/00
Filed: 1985-10-07
Granted: 1987-04-23
Abstract: In the case of a method for producing rigid-flexible multilayer circuits, using rigid printed circuit boards and flexible metal-plastic laminates, both the rigid and the flexible regions of the multilayer circuit initially containing rigid printed circuit board parts, and the latter being removed in the flexible regions once processing has been carried out, the mutually adjacent printed circuit board parts are connected, such that they are completely separated from one another by continuous joints, in a flat manner to the flexible laminate, under the influence of pressure and heat. An isolating film, a thermoplastic pressure compensation film and a reinforcing film are applied onto the outer surfaces of the printed circuit board parts, so that the material of the pressure compensating film penetrates into the joints between the printed circuit board parts and connects and seals them. After removal of the three attached films and further processing of the rigid regions, those printed circuit board parts which lie over the flexible regions can be removed.
Patent DE-3826514-C1 (DE)
Title: Profile arrangement for spanning a settlement joint
IPC: E04B1/68
Filed: 1988-08-04
Granted: 1989-12-07
Abstract: Taken as departure point in order to span a settlement joint is a profile combination comprising two anchorage profiles (1) which are arranged in a mirror-inverted manner with respect to one another. These retain a spanning profile (2) which is made up of two profile parts (3, 4). The profile parts (3, 4) are configured in the form of lengths, connected to one another at an upper border strip via an articulation and are likewise mounted in an articulated manner, by means of their lower border strips, in the anchorage profiles (1). Covering strips (15, 16) integrally formed on the common upper articulation rest, with concave undersides, on convex upper sides of carrying mouldings (17) which are integrally formed on the vertical legs (8) of the anchorage profiles (1). The centre axes of the concave and convex undersides and upper sides of the covering mouldings (15, 16) and carrying mouldings (17), respectively, coincide with the centre axes of the lower pivot axes of the profile parts (3, 4). <IMAGE>
Patent DE-3832214-C1 (DE)
Title: Process for exchanging a buried pipeline, and apparatus for carrying out the process
IPC: E21B7/28
Filed: 1988-09-22
Granted: 1989-12-28
Abstract: The invention relates to a process for exchanging a buried pipeline (16), in particular a seepage-water line for renovating recycling dumps, and to an apparatus for carrying out the process. The invention proposes to advance a high-strength assembly pipe (2) over and along the pipeline (16) which is to be exchanged, an apparatus breaking the pipeline up into fragments (19). Advancement proceeds, with the aid of a centring element, in the pipeline (16) which is to be exchanged. The pipeline pieces (19) are removed from the assembly pipe (2), and a new pipeline (21) is introduced under the protection of the assembly pipe (2). The assembly pipe (2) is then removed again. By means of this process, large pipeline portions can be exchanged in one piece, it being virtually impossible for the new pipeline (21) to be subjected to loading or damaged by the operating procedure. <IMAGE>
Patent DE-3902595-C1 (DE)
Title: Fibre-reinforced shaped body
IPC: C04B28/02
Filed: 1989-01-28
Granted: 1990-05-03
Abstract: Shaped bodies (mouldings) containing reinforcing fibres, in particular structural boards, comprising a hydraulic binder, such as cement, are to be provided, in which bodies the reinforcing fibres can be all natural organic fibres, such as cellulose, paper, flax, hemp, jute etc. and/or cellulose derivatives such as cellulose acetate and/or organic synthetic fibres such as polyacrylonitrile fibres and/or inorganic fibres, namely glass fibres and rock wool and/or further synthetic mineral fibres, with the shaped bodies being supposed to have, despite the use of the specified fibres, a long lifetime during which the strength values should, at the most, decrease only slightly. For this purpose, it is provided according to the invention for the finished shaped bodies or structural boards to contain a water-soluble proportion of sodium (Na2O) which is less than 10 mg/10 g of solid and/or for the finished shaped bodies or structural boards to contain a water-soluble proportion of potassium (K2O) which is less than 15 mg/10 g of solid.
Patent DE-3911489-C1 (DE)
Title: Apparatus for filling racking-off bags with bulk material to be compacted and consisting especially of bark mulch or peat
IPC: B30B9/30
Filed: 1989-04-08
Granted: 1990-10-18
Abstract: A conventional apparatus for filling racking-off bags requires a considerable constructional space. As a result of the complex design, the costs for the construction and maintenance of an apparatus of this type are likewise considerable. In order, in contrast to this, to provide an apparatus of comparatively simple design, in which cubic pressing is possible even in the case of different bulk materials to be compacted, provision is made for designing the apparatus as a stationary apparatus executing at least two work cycles from the same workstation. The compacting ram (3) is always guided in the vertical filling shaft (1). In its upper filling position, it exposes a lower loading window (7), via which the filling material can be supplied. The apparatus is especially suitable for the filling and compaction of bark mulch or peat. <IMAGE>
Patent DE-3935840-C1 (DE)
Title: Drive belt etc. tensioner with spring-loaded tension roller - has prestressing bimetal spring for friction damping
IPC: F16H7/08
Filed: 1989-10-27
Granted: 1991-05-02
Abstract: The drive belt tensioner includes a location spigot (2) for an eccentric flange sleeve (5), whose angular movement on the spigot produces the belt tensioning force. A bimetal spring washer (11), which is in axial friction contact with another washer (9), and a retaining collar (10) on the spigot, produces temp. related torsional damping between the location spigot and the eccentric flange sleeve. ADVANTAGE - Swivel motion damping at all operating conditions.
Patent DE-3939398-C1 (DE)
Title: Protective circuit for electroacoustic transducer - has autotransformer with prim. winding connected to reference potential via cold conductor only during transmit mode
IPC: H04R3/00
Filed: 1989-11-29
Granted: 1991-01-24
Abstract: The overload protection circuit uses a cold conductor (i.e.  positive temp. coefft. resistor element against thermal overloading.  An electro-acoustic transducer, working either as a transmitter or a receiver, is connected to the cold conductor (PTC) and the winding (W2) of an autotransformer in series. The circuit, feeding the transducer during transmission and fed by it during reception, is connected in series with the prim, winding (W1) of the transformer and the cold conductor. USE/ADVANTAGE - Simple circuit protecting transducer, selectively working as either a transmitting or receiving transducer, against thermal or current overloading. In receiving mode, i.e. at low signal amplitudes, characteristics remain unaffected.
Patent DE-4137019-C1 (DE)
Title: Canula bore non-return valve - has two spring closed valves to control supply of medicament
IPC: A61M39/26
Filed: 1991-11-11
Granted: 1992-11-12
Abstract: Retention canula bore nonreturn valve comprises two pre-spring closed valves in the bore which bear against one another when closed and are forced open by the cone part of a connection line thrust into the canula bore. The two valves (5) should be block shaped and arranged in guide holes in the main housing, the valves close under springs (6) which sit at the valve end furthest from the canula bore (2). The valve endfaces (8) are angled towards the patient relative the axis of the bore. USE/ADVANTAGE - Medical treatment, infusion, medicament supply etc. Low cost twin valve canula bore opens/closes under strict control of springs.
Patent DE-4204629-C1 (DE)
IPC: D03C7/06
Filed: 1992-02-15
Granted: 1993-03-04
Abstract: In the device proposed, the frame is designed as a guide element (3) for the yarn guide (4), the yarn guide (4) having a recess (3a) designed to accommodate the guide element (3).
Patent DE-4212336-C1 (DE)
IPC: F23J15/00
Filed: 1992-04-13
Granted: 1993-09-02
Abstract: The system comprises a rotating heat-transmission installation (3), in which the waste gas (AG) leaving the boiler (1) fired with brown coal is cooled, and the heat extracted in this connection from the waste gas (AG) serves for regulating the temperature of the combustion air (VL) introduced into the boiler (1). Provided parallel to the heat-transmission installation (3) is a heat displacement unit (5), with the aid of which primary air (PL) is preheated with the heat of the waste gas (AG1) leaving the heat-transmission installation (3). The heat-transmission installation (3) is bridged by a bypass (13) with a heat exchanger (14) which can be acted upon by waste gas (AG). Boiler feed water (KSW) flows in the heat exchanger (14). This water is heated with the waste gas (AG). It is possible to connect at least indirectly to the heat-displacement unit (5) a further heat exchanger (18), with the aid of which the waste gas (AG4) leaving a smoke-gas desulphurisation installation (21) can be brought to a sufficiently high temperature for charging a fireplace (22). 
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Patent DE-4223538-C1 (DE)
Title: Device to damp effect of  exploding munition on window - comprises optically transparent, UV-resistant screen plate with no tendency to splinter
Inventor: KLIER HERMANN
IPC: F41H5/04
Filed: 1992-07-17
Granted: 1993-11-04
Abstract: The screen plate (7) is made of plastic and is inclined against the window pane (1). The centre of the screen plate is arranged at a distance of 0.5 m to 1.0 metres in front of the window pane and can be rolled up. Behind the window pane is an inner plate (4) of optically transparent, UV-resistant plastic with no tendency to splinter. The screen plate and inner plate are pref. of polycarbonate or plexiglas (RTM). USE/ADVANTAGE - To protect a window against the effect of a munition explosion.
Patent DE-4244119-C1 (DE)
Title: Protecting relay contacts against overloading - using controlled switch with switching path in parallel with contacts and monitoring elements for load current circuit
Inventor: THIEMANN H-JOACHIM
IPC: H02H3/087
Filed: 1992-12-24
Granted: 1994-03-24
Abstract: An electric load (5) can be connected to a voltage supply (6) via relay contacts (2a). A controllable switch (4) is connected parallel with the contacts (2a). Control electronics (1) control the relay (2) and switch (4). Monitoring elements, including overcurrent (3) and voltage (7) sensors, monitor the load current loop (2a, 3, 5, 6). The current sensor (3) checks if the load current exceeds a given threshold and, if so, provides an over-load signal (U) to the control electronics (1). The latter (1) then switches both the relay (2) and the switch (4) off. After a short pause (c), the electronics (1) checks the load voltage through the voltage sensor (7). When a voltage above a given threshold is registered, the electronics (1) switches the switch (4) on for a short time. This continues as long as the overload signal (U) is applied. ADVANTAGE - Simple, inexpensive way to protect relay contacts from burning or damage even with very high loading.
Patent DE-4316310-C1 (DE)
Title: Display case for receiving advertising or information media
Inventor: TEGTMEIER DIETRICH DIPL ING
IPC: G09F19/12
Filed: 1993-05-14
Granted: 1994-12-01
Abstract: In order to provide a display case for receiving advertising or information media, comprising an upright frame made of metal having at least one transparent panel, behind which the information media are arranged, with electric components, installations and lighting means being installed in the interior of the display case, whereby excessively high temperatures of the inner space can be largely avoided, it is proposed that the frame be of a construction forming a hollow channel (4) running all the way round, the hollow channel (4) forming the lower frame side (5) having air outlet slots (7) to the inner space (6) of the display case, and another frame side, preferably the hollow channel (4) forming the upper frame side (8), having air inlet slots (9), and that in the region of the inlet slots (9) or outlet slots (7) there be arranged a blower (10) by means of which air circulation from the inner space (6) of the display case to the air inlet slots (9), through the hollow channel (4) and the air outlet slots (7) to the inner space (6) of the display case is brought about. <IMAGE>
Patent DE-4318950-C1 (DE)
Title: Tissue spreading device
Inventor: JANCOVICI RENE PROF
IPC: A61B17/00
Filed: 1993-05-25
Granted: 1994-09-29
Abstract: The invention relates to an endoscopic tissue spreading device (1) which can be employed to spread cavities in the body with a spherical cage consisting of individual leaves (2). <IMAGE>
Patent DE-4410048-C1 (DE)
Title: Synchronisation of a forward gear by user of a reverse gear
Inventor: HAAS HERBERT DIPL ING
IPC: F16H63/30
Filed: 1994-03-23
Granted: 1995-05-18
Abstract: Catch link (17) is connected with a gear shift arrangement, to move the shift rod (23) through engagement of the contoured catch stub (32) with the eccentric rolling actuator (20). The latter swings on a pivot (21), moving the contoured cam (22) on the shaft (25), pressing first to synchronise the forward gear, then relieving the load on the gear shift before the end position is reached.
Patent DE-4411560-C1 (DE)
Title: Chemical oxygen@ supply equipment
Inventor: SCHWICHTENBERG MICHAEL DR
IPC: A62B18/08
Filed: 1994-04-02
Granted: 1995-08-03
Abstract: One or more chemical cartridges (2) in a housing (1) absorb carbon dioxide and give off oxygen gas. An exhalation bag (3) is contained in an inhalation bag (7), and inhalation (4) and exhalation (5) valves are included, together with a particle filter (6). A power source (10) for the fan (8) may be connected to the evaluator (9) and can be accommodated in the housing. The cartridges can consist of double-skinned vessels accommodating a coolant and containing ignition equipment (2) connected to the evaluator. A pressure-relief valve (11) can be mounted in the exhalation valve.
Patent DE-4423066-C1 (DE)
Title: System with mobile data carriers for wireless data transfer
Inventor: ANSORGE ULRICH DIPL ING
IPC: G06K7/08
Filed: 1994-07-01
Granted: 1995-12-07
Abstract: The system data carriers (1), each contg. an esp. electrically erasable programmable read-only memory chip (2) and microprocessor (3), are coupled either galvanically, inductively or capacitively for signal transmission to a separate module (14). The memory contains data related to e.g. the type, colour and other characteristics of an object (11) to which the data carrier is attached. The module contains a receiving antenna (15) connected to a bridge rectifier (17). The transmitting antenna (22) is fed (24) from a tri-state driver (9) for communication with a more distant transmission and/or interrogation unit (12) including a modulated data transceiver (13).
Patent DE-4424768-C1 (DE)
Inventor: KOPPE KURT PROF DR ING
IPC: B05D3/08
Filed: 1994-07-05
Granted: 1995-11-09
Abstract: A process and device are disclosed for coating elongated or slightly curved metallic substrates with a preferably powdery, plastic-based coating agent. An effective, energy saving coating process that avoids the danger of dust explosion has the following steps: (a) the substrate to be coated is fixed; (b) the substrate to be coated and/or the coating device are moved in a working direction; (c) the substrate to be coated is heated in a localised area by means of a gas flame up to a temperature from 80  DEG C to 900 DEG C; (d) at a defined distance behind the gas flame, the working area located between the gas flame and the following area, in which the coating agent is applied, is sealed by a partition and by a blocking layer made of a non-flammable, gaseous medium and formed between the partition and the surface of the substrate to be coated in order to prevent powder-loaded air from igniting; (e) the coating agent is applied on the hot metallic surface of the substrate to be coated in a manner known per se; and (f) when the coating process is finished, the coated substrate is released. This process is the first that allows metallic substrates to be coated by localised heating of the substrate by means of a gas flame.
Patent NL-1017747-C1 (NL)
Title: Simulator for working environment of anaesthetist, has expert system forming interface between medical model and medical data input unit
Inventor: MIJZEN GERBRAND JURRIAAN
IPC: G06F19/00
Filed: 2001-03-30
Granted: 2002-10-01
Abstract: The computer system comprises an expert system (12) which during use forms an interface between the medical model and the input/output unit (4).  The simulator is used to simulate e.g. a patient undergoing medical treatment and includes a computer system with a relational databse (10) and an input/output unit for inputting medical treatment data (6.1) and/or patient parameters or characteristics (6.2). The relational database comprises a medical model of a medical condition of the patient, the condition including prim. effects such as the level of consciousness and level of pain suppression. The prim. effects are a function of the medical treatment data and/or patient parameters. During use, the computer system calculates the prim. effects for the patient as a function of the inputted medical treatment data and/or patient parameters.
Patent NL-1018038-C1 (NL)
Title: Very large beam swing for children is suspended between beams and not posts and has no small board, but children must put on safety strap with which they are fixed to swing rope
Inventor: HUYGEN PETER-PAUL
IPC: A63G9/00
Filed: 2001-05-10
Granted: 2002-06-11
Abstract: Very large beam swing for children is suspended between beams and not posts and has no small board, but children must put on a safety strap, with which they are fixed to the swing rope. The components of the swing comprise 176 meter, thick manilla natural rope with 2 centimeter cross-section, 6 meter thin manilla natural rope, 1 centimeter cross-section with breaking strength 635 kilograms, 3 large wooden cat rollers (7,8,9), 5 harp connections with breaking strength 3.25 ton (see 10), 3 iron rings cross-section 8.5 centimeter, thickness 12 millimeter, 3 screw snap links (12), breaking strength 25 kilonewton, and at least one integral strap, child format. The ropes are divided into pieces, (1) is 22 meter lonng, (2,3) are 42 meter long, (4,5) are 12 meter long. It is possible to select ropes which are 6, 8, 10 and 12 meter long (6,8,10,12), (13,15) are 5 meter long and 4 reserve ropes each of 5 meter are provided. The thin rope (6) is divided into 3 pieces of 2 meter.
Patent NL-1021618-C1 (NL)
Title: Door handle cover, made from serviette paper and used to prevent hands from getting dirty
Inventor: PETERS KARIM
IPC: E05B1/00
Filed: 2002-10-10
Granted: 2002-11-05
Abstract: The cover is a disposible one made from strong serviette paper and is optionally treated with a disinfectant. The cover has an opening (1) so that it can be slid over the handle.
Patent NL-1026764-C1 (NL)
Title: Protective case for books, comprises two parts which are slid together and contain openings for elastic band
Inventor: WIJNEN CHARLES GODEFRIDUS JOHA
IPC: B42D3/04
Filed: 2004-08-02
Granted: 2005-09-05
Abstract: The case comprises two separate parts (4) which are slid together. Each part contains a small opening (2) and a large opening (1) so that an elastic band can be passed through each opening and around the book(s) inside the case. The case has one open side.