Patent SG-11201901937W-A (SG)
Title: Pyridine compound
Inventor: INAGAKI HIROAKI
IPC: C07D413/14
Filed: 2017-09-28
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD HIM 0 11101 HOE HI 1 0 011101 RIM 010 HI HI Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\"1 WO 2018/060714 Al 05 April 2018 (05.04.2018) WIP0 I PCT (51) International Patent Classification: HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, CO7D 401/14 (2006.01) A61K 31/4709 (2006.01) KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, CO7D 413/14 (2006.01) A61P 35/00 (2006.01) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (21) International Application Number: OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, PCT/GB2017/052913 SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (22) International Filing Date: (84) Designated States (unless otherwise indicated, for every 28 September 2017 (28.09.2017) kind of regional protection available): ARIPO (BW, GH, (25) Filing Language: English GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (26) Publication Language: English UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (30) Priority Data: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 2016-191725 29 September 2016 (29.09.2016) JP MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (71) Applicant: DAIICHI SANKYO COMPANY, LIMIT- KM, ML, MR, NE, SN, TD, TG). ED [JP/JP]; 3-5-1, Nihonbashi Honcho, Chuo-ku, Tokyo, 103-8426 (JP). Declarations under Rule 4.17: (72) Inventors: INAGAKI, Hiroaki; c/o Daiichi Sankyo — of inventorship (Rule 4.17(iv)) Company, Limited, 3-5-1, Nihonbashi Honcho, Chuo-ku, Published: Tokyo, 103-8426 (JP). SHIBATA, Yoshihiro; c/o Dai- — with international search report (Art. 21(3)) ichi Sankyo Company, Limited, 3-5-1, Nihonbashi Honcho, = Chuo-ku, Tokyo, 103-8426 (JP). NAMIKI, Hidenori; c/o _ Daiichi Sankyo Company, Limited, 3-5-1, Nihonbashi Hon- =_ cho, Chuo-ku, Tokyo, 103-8426 (JP). KAGEJI, Hideaki; c/o Daiichi Sankyo Company, Limited, 3-5-1, Nihonbashi — Honcho, Chuo-ku, Tokyo, 103-8426 (JP). NAKAYAMA, = Kiyoshi; c/o Daiichi Sankyo Company, Limited, 3-5-1, Ni- - _ honbashi Honcho, Tokyo, 103-8426 KANE- Chuo-ku, (JP). TA, Yasuyuki; c/o Daiichi Sankyo Company, Limited, = — 3-5-1, Nihonbashi Honcho, Chuo-ku, Tokyo, 103-8426 = (JP). = (74) Agent: HGF LIMITED; 4th Floor, Merchant Exchange, 17-19 Whitworth Street West, Manchester Ml 5WG (GB). = = (81) Designated States (unless otherwise indicated, for every = kind AE, AG, AL, AM, of national protection available): = AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, = DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, = = = (54) Title: PYRIDINE COMPOUND = _ - CH3 i 0 7r H3 01 „ C Il IN © V::+ 0 (I) --.... 00 1-1 © (57) : The present invention relates to a compound having RET kinase inhibiting action or a pharmaceutically acceptable salt el thereof, useful in the treatment of diseases such as cancer. In particular a compound represented by the following general formula (I) C as defined herein: (I) or a pharmaceutically acceptable salt thereof.