Patent SG-11201810359P-A (SG)
Title: (2s)-1-[4-(3,4-dichlorophenyl)piperidin-l-yl]-3-[2-(5-methyl-l,3,4-oxadiazol-2-yl)benzo[b]furan-4-yloxy]propan-2-ol or its metabolite for treating anxiety disorders
Inventor: LUTHRINGER REMY
IPC: A61K31/454
Filed: 2017-05-23
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111 01110111101111111101111111 01111111110110011101110111110 MIMI Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\"1 WO 2017/205399 Al 30 November 2017 (30.11.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 31/454 (2006.01) A61P 25/22 (2006.01) kind of national protection available): AE, AG, AL, AM, (21) International Application Number: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, PCT/US2017/034036 CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (22) International Filing Date: HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, 23 May 2017 (23.05.2017) KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (25) Filing Language: English PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (26) Publication Language: English SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, (30) Priority Data: TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 62/341,517 25 May 2016 (25.05.2016) US (84) Designated States (unless otherwise indicated, for every 62/373,720 11 August 2016 (11.08.2016) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (71) Applicant: MINERVA NEUROSCIENCES, INC. UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, [US/US]; 1601 Trapelo Road, Suite 284, Waltham, Massa-TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, chusetts 02451 (US). EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (72) Inventor: LUTHRINGER, Remy; 2 me de Jargonnant, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 1207 Geneva (CH). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (74) Agent: ERLACHER, Heidi A. et al.; Cooley LLP, 1299 Pennsylvania Avenue, NW, Suite 700, Washington, District Declarations under Rule 4.17: of Columbia 20004 (US). — as to applicant's entitlement to apply for and be granted a = = patent (Rule 4.1700) = = Title: (2 S)-1 44-(3,4-DICHLOROPHENYL)PIPERIDIN-L-YL]-342 -(5 -METHYL-L,3,4 -OXADIAZOL-2 -YL)BENZO [ (54) B]FURAN-4-YLOXY]PROPAN-2-OL OR ITS METABOLITE FOR TREATING ANXIETY DISORDERS (57) : The present disclosure describes compositions and methods for treating at least one symptom of an anxiety disorder in a human subject. ge from Baseline (Obsered Data) by Treatment Arm The compositions and methods employ a therapeutically effective amount = — — = = Week 1 Week 2 Week 4 Week of a compound of formula I (Compound I) or formula II (Compound II, or a pharmaceutically acceptable salt, hydrate or solvate of Compound I or II. = = 6 = = _,0 = Pigure I_ = = = ( 1 ) or 11 4 V : M in -1 0 ei i i FI (ii) N ,-1 . H OH © ei C [Continued on next page] WO 2017/205399 Al MIDEDIMOMMIDIRMEM001010111101110HOHOMEMOIMIE Published: — with international search report (Art. 21(3))