Patent EA-000189-B1 (EA)
Title: Composition based on alcaloids having an eburnamenine nucleus for stimulation of cerebral activity
Inventor: LAZARO FLORES CONSUELO
IPC: A23L27/20
Filed: 1996-04-10
Abstract: 1. Composition for oral administration to stimulate cerebral activity, characterized in that it comprises a compound containing a) alcaloids of the eburnamenine type of general formula I:   wherein R represents H or -OH; or between C-14 and C-15 exists double bond, R' represents -OH or CO2R'', and R'' comprises from 1 to 6 carbon atoms R' '' represents H, halogen (such as bromine or chlorine) or nitro group, having natural origin and being in a free form or in an extract, or having synthetic or semi-synthetic origin; b) xantine bases of general formula II   wherein R represents H, CH3 or -(CH2)4-CO-CH3, R' represents CH3 or -CH2-CH2-CH3, having natural origin and being in a free form or in an extract, or having synthetic or semi-synthetic origin; such as xantine bases which can be (1) in beverages of cola, lemon, cocoa, ginseng, tonic water, coffee or any other beverage or in (2) in dry, semi-dry or wet, granulated, powder-like, flowing, viscous or semi-viscous extracts of coffee, cola, cocoa, tea, ginseng, lemon, tonic water or in other similar extracts; wherein said composition contains quantities comprised between 0.5 and 10 mg of alcaloids or extract of alcaloids of the eburnamenine type per 100 ml (b), (1) or in quantities comprised between 0.4 and 30 mg of alcaloids or extracts, of alcaloids of the eburnamenine type per each 5-20 g (b), (2). 2. Composition according to Claim 1, characterized in that said alkaloid of the eburnamenine type represents vinpocetine or any other pharmaceutically acceptable salt of addition, which are either of natural origin and obtained from plants extracts or synthetic/semi-synthetic origin. 3. Composition according to Claim 1, characterized in that said alkaloid of the eburnamenine type represents vincamine or any other pharmaceutically acceptable salt of addition, which are either of natural origin and obtained from plants extracts or synthetic/semi-synthetic origin. 4. Composition according to Claims 1-3, characterized in that said xantine represents caffeine either of natural origin, found in extracts of plants, containing it, or of synthetic/semi-synthetic origin. 5. Composition according to Claims 1-3, characterized in that said xantine represents teobromine or any other pharmaceutically acceptable salt of addition, which are either of natural origin and obtained from plants extracts or synthetic/semi-synthetic origin. 6. Composition according to Claims 1-5, characterized in that it contains aerated or non aerated water or not toxic liquid, used in food industry. 7. Composition according to Claims 1-4 or 6, characterized in that said extract represents instant coffee with different caffeine content. 8. Composition according to Claims 1-4 or 6, characterized in that said extract is obtained from tea. 9. Composition according to Claims 1-4, characterized in that said extract is obtained from instant cocoa. 10. Composition according to Claims 1-4, characterized in that said extract is obtained from soluble ginseng roots. 11. Composition according to Claims 1-4, characterized in that said extract is obtained from mate herb. 12. Composition according to Claims 1-4, characterized in that said extract is obtained from cola. 13. Composition according to Claims 1-4, characterized in that said added fluid represents a fruit juice or its substitute. 14. Composition according to Claims 1-4, characterized in that said added fluid represents a beverage, usually named "tonic water" and which usually contains quinine. 15. Composition according to Claims 1-4, characterized in that said added fluid represents the so called in food industry "bitter refreshing beverage", "bitter" or "amaro or amaretto" 16. Composition according to any of the preceding Claims characterized in that it is in a concentrated form. 17. Composition according to Claims 1-15, characterized in that it is in a deluted form.