baber/WOPTO huggingface dataset:
Patent CO-6331372-A2 (CO)
Title: Inhibidor de parp 4-yodo-3-nitrobenzamida o un metabolito de la misma
Inventor: OSSOVSKAYA VALERIA S
IPC: C12Q1/68
Filed: 2010-08-27
Abstract: Se describen métodos para la identificación de una enfermedad tratable con moduladores de genes expresados de manera diferencial en una enfermedad, incluyendo al menos moduladores PARP, por identificación del nivel de expresión de genes expresados de manera diferencial, incluyendo al menos PARP, en una pluralidad de muestras de una población, tomándose una decisión con respecto a la identificación de la enfermedad tratable mediante moduladores para los genes expresados de manera diferencial, en los que la decisión se toma basándose en el nivel de expresión de los genes expresados de manera diferencial. El método puede comprender además tratar la enfermedad en una población de individuos con moduladores de genes expresados de manera diferencial identificados. Los métodos se refieren a la identificación de expresión regulada de manera ascendente de genes expresados de manera diferencial identificados en una enfermedad y a la toma de una decisión respecto al tratamiento de la enfermedad. El nivel de expresión de los genes expresados de manera diferencial en una enfermedad también puede ayudar a determinar la eficacia del tratamiento con moduladores para los genes expresados de manera diferencial.
Patent CO-6331368-A2 (CO)
Title: Factores modificados de polipeptidos vii (fvii)
Inventor: MADISON EDWIN L
IPC: C12N9/64
Filed: 2010-10-13
Abstract: Se proporcionan polipéptidos del factor VII modificados y usos de los mismos. Tales polipéptidos FVII incluyen el Factor Vila y otras formas de Factor VII. Entre los polipéptidos FVII codificados proporcionados están aquellos que tienen actividades alteradas típicamente actividad procoagulante alterada, incluyendo actividades procoagulantes incrementadas. Por lo tanto, tales polipéptidos son terapéuticos.
Patent CO-6531414-A2 (CO)
Title: Aptámeros del inhibidor de la vía del factor tisular y sus usos como tratamiento de trastornos hemorrágicos
Inventor: SCHAUB ROBERT G
IPC: A61K48/00
Filed: 2012-03-16
Abstract: La invención se refiere en términos generales al campo de los ácidos nucleicos, y particularmente a los aptámeros que se ligan a TFPI, que son útiles en la terapia y diagnóstico de los trastornos de sangrado y/o de otras enfermedades o trastornos en los que se ha involucrado el TFPI. Además, los aptámeros de TFPI pueden ser utilizados antes, durante o después de procedimiento médicos a efectos de reducir las complicaciones efectos colaterales de los mismos. La invención se refiere además a métodos y materiales para la administración de los aptámeros que se ligan a TFPI.
Patent CO-6640233-A2 (CO)
Title: Sistema de electrolización
Inventor: SWARTZ GREGORY JOHN
IPC: C25B9/23
Filed: 2012-11-21
Abstract: Se proporciona un sistema de electrolización para electrolizar una solución de salmuera de agua y una sal álcali para producir agua electrolizada acídica y agua electrolizada alcalina; el sistema incluye una cámara interna para recibir la solución de salmuera y dos celdas de electrolizador sumergidas en un baño de salmuera; cada celda de electrolizador incluye un electrodo, al menos una membrana permeable a los iones soportada con relación al electrodo para definir un espacio que se comunica entre un suministro de agua dulce y una salida de producto químico dentro de la cual entra la salmuera solamente a través de la membrana; uno de los electrodos está acoplado a un suministro eléctrico de carga positiva y el otro a un suministro eléctrico de carga negativa.
Patent CO-7160067-A2 (CO)
Title: Formulaciones de agonistas del receptor de somatostatina
Inventor: NISTOR CATALIN
IPC: A61K47/24
Filed: 2014-12-18
Abstract: Intermediarios y procesos útiles para la síntesis sencilla de moléculasbiológicamente activas.
Patent EP-1041279-A2 (EP)
Inventor: MOYA JUAN
IPC: F04B1/20
Filed: 2000-03-08
Abstract: The actuator part (5) is supported on a bearing face and has two pressure channels (40,41). One of the channels is connected a relief channel (30,31) opening on a counter face (35) of the actuator part opposite to the bearing face and/or to a lubricant channel (32,33). Relief and/or lubricant channel open into an area (56) opposite to the associated pressure channel. The lubrica channel has a throttle element (58,60) and an auxiliary channel (63,64) branching off a main channel downstream of the throttle. lubricant channel simultaniously acts as relief channel.
Patent EP-1052124-A2 (EP)
Inventor: HIROTA HISATOSHI
IPC: B60H1/32
Filed: 2000-04-05
Abstract: A vehicular refrigerating cycle with a by-pass line 55 is provided, whereby even in an
environment of extremely low temperature with the refrigerating cycle left at rest after
being operated in cooling mode, refrigerant accumulated in a condenser can be driven
out of said condenser 52 to provide subsequent heating functions by an evaporator 54 in
a prescribed manner. 
     Capacity control means 20 can be set such that the capacity of a compressor 10 only is
allowed to start to decrease from a maximum capacity when a compressor suction
pressure Ps has dropped to a value of 2 atmospheres (absolute pressure) or less in a
state in which refrigerant flows through condenser 52 without passing through by-pass
line 55.
Patent EP-1060952-A2 (EP)
Inventor: WILLNER WILFRIED DIPL-ING
IPC: B60Q3/06
Filed: 2000-06-03
Abstract: The movement damper (1) has a stationary housing (2) enclosing a relatively sliding coupling element (6) attached to the movable component. A push-button switch (7) with a pair of electrical contacts is attached to the stationary housing, the switch operating element (11) attached to the coupling element, for pressing the switch contacts together dependent on the position of the movable component, e.g. for closure of an illumination light source circuit.
Patent EP-1063381-A2 (EP)
IPC: E05G1/00
Filed: 2000-06-23
Abstract: The locking unit (2) is entirely fixed beneath the cover (1) of the security box together with operating means and control system. Touch switches (3) are accessed through holes (5) and an evaluation unit (4) checks the code and releases the bolt (7) by motorized or magnetic means.
Patent EP-1074306-A2 (EP)
Inventor: EICKMEYER DIETMAR DR
IPC: B05B12/00
Filed: 2000-07-14
Abstract: Electrostatically sprayed paint parameters suitable as input values for a paint spraying device are determined via at least one artificial neuronal network where each parameter is available as out output of the network. Initially, a learning phase involves inputting a number of realistic measured values into the network or into several networks to provide a paint thickness distribution and the associated realistic spray parameters. User phase input values are applied to the network or networks and result from an analysis of the paint thickness distribution of a specified spray result.
Patent EP-1081327-A2 (EP)
Inventor: PROSCH DIETER
IPC: E06B9/322
Filed: 2000-07-20
Abstract: The cord to be wound is guided onto the core (30) and its axial position depends upon the angle position of the core. The roller incorporates an eccentric disk (20) located rotatably movably coaxially to the winding core (30) and which has a cylinder surface (23) coaxial to the winding core. In the cylinder surface is an all-round guide groove (24) inclined to the axis of the winding core.   A step gear is available, which converts the continuous rotary movement of the winding core into a staged linear movement of the cord guide member. The winding core has a bearing (33) for a driver component movable between rest and engagement positions, preferably an axially movable pin. The eccentric disk has at least one recess (12) in which the driver component secures in the engagement position.
Patent EP-1071099-A2 (EP)
Inventor: ISHIDA YOSHIHIKO
IPC: H01C7/02
Filed: 2000-03-30
Abstract: An inorganic-metal composite body exhibiting PTC behavior at a trip point
temperature ranging from 40°C - 300°C, including an electrically insulating inorganic
matrix having a room temperature resistivity of at least 1 x 10 6  Ω·cm, and electrically
conductive particles uniformly dispersed in the matrix and forming a three-dimensional
conductive network extending from a first surface of said body to an opposed second
surface thereof wherein the composite body has a room temperature resistivity of no more
than 10 Ω·cm and a high temperature resistivity of at least 100 Ω·cm. Preferably, the
electrically conductive particles are made of a Bi-based alloy containing at least 50 wt %
Bi, and have an average diameter,  ave , of 5-50µm and a 3σ particle size distribution of 0.5
 ave -2.0  ave . Also disclosed is an inorganic PTC device including an intermediate
electrode layer to insure adhesion of outer termination electrodes to the PTC composite
body, and a method of forming the composite body, which method effectively deals with
the volatility of the electrically conductive particles.
Patent EP-1109242-A2 (EP)
Inventor: KNEIDEL KURT E
IPC: H01M8/24
Filed: 2000-11-16
Abstract: A fuel cell manifold arrangement (5) includes a fuel cell stack (103) and
a manifold enclosure (10) connected to and sealed to an inlet side of the fuel
cell stack (103) and defining with the stack a gas plenum (21) for receiving a
fuel gas (14) for the fuel cell stack (103). A catalyst screen (15) is connected
to the manifold enclosure (10) for defining a gas passage for passing fuel gas
(14) and for containing a catalyst (13) that is bounded by the screen (15). The
manifold enclosure (10) has a gas inlet for receiving fuel gas (14), the gas inlet
communicating with the screen (15) for passing fuel gas (14) through the
screen (15) and past the catalyst (13). A plate (12) in the manifold enclosure
(10) separates the catalyst (13) from the plenum (21), and heat insulation (23)
is provided on at least part of the manifold enclosure (10) and on at least part
of the plate (12) for insulating the manifold enclosure (10) from the fuel cell
stack (103) and from an exterior of the manifold enclosure (10). A passage
(24) in the manifold enclosure (10) connects the screen (15) to the plenum (21)
for passing fuel gas (14) from the catalyst (13) to the plenum (21).
Patent EP-1112752-A2 (EP)
Inventor: SAITOU AKIKO
IPC: A61L9/20
Filed: 2000-12-20
Abstract: An odor removing apparatus 10. 
     An ultraviolet ray source 3 radiates ultraviolet
rays on a plurality of photocatalytic beads 4. An
enclosure 1 allows an airflow and accommodates the
light source 3 and the photocatalytic beads 4.
Patent EP-1043835-A2 (EP)
Inventor: KADOTA MICHIO
IPC: H03H9/02
Filed: 2000-04-07
Abstract: An edge reflection type surface acoustic wave device (1) includes a
surface acoustic wave substrate (2) made of a piezoelectric single crystal
and having first and second opposite edges (2a,2b), and at least one
interdigital transducer (3,4) disposed on the surface acoustic wave
substrate. The surface acoustic wave device (1) is constructed such that
a Shear Horizontal type surface acoustic wave is reflected between the
first and second opposite edges (2a,2b). The surface acoustic wave
substrate (2) is made of an ion-implanted piezoelectric single crystal
substrate.
Patent EP-1063309-A2 (EP)
Inventor: BHARGAVA ASHOK K
IPC: C22F1/00
Filed: 2000-05-30
Abstract: The present invention relates to copper-magnesium-phosphorous
alloys. In a first embodiment, copper-magnesium-phosphorous
alloys in accordance with the present invention
contain magnesium in an amount from about 0.01 to about 0.25% by
weight, phosphorous in an amount from about 0.01 to about 0.2% by
weight, silver in an amount from about 0.001 to about 0.1% by
weight, iron in an amount from about 0.01 to about 0.25% by
weight, and the balance copper and inevitable impurities.
Preferably, the magnesium to phosphorous ratio is greater than
1.0. In a second embodiment, copper-magnesium-phosphorous alloys
in accordance with the present invention contain magnesium in an
amount from about 0.01 to about 0.25% by weight, phosphorous in
an amount from about 0.01 to about 0.2% by weight, optionally
silver in an amount from about 0.001 to about 0.1% by weight, at
least one element selected from the group consisting of nickel,
cobalt, and mixtures thereof in an amount from about 0.05 to
about 0.2% by weight, and the balance copper and inevitable
impurities.
Patent EP-1083579-A2 (EP)
Title: Arrester
Inventor: SCHMIDT WALTER
IPC: H01C7/12
Filed: 2000-08-15
Abstract: The overvoltage diverter has an earthed cylindrical housing (10) receiving a HV terminal (5) and enclosing an active part (8) extending along its longitudinal axis, provided with at least one varistor element (9), held in contact with opposing end terminations (1,2) via a tensioning loop passed around the latter. The active part is insulated from the cylindrical housing via an insulation sleeve (13), with a current conductor (3) fitting through a necked section of the housing between one of the end terminations and the HV terminal.
Patent EP-1144368-A2 (EP)
Inventor: LEVIN JEREMY IAN
IPC: A61P1/00
Filed: 2000-01-27
Abstract: Cette invention concerne des composés correspondant à la formule (B) qui sont utiles dans le traitement d'états maladifs induits par le facteur de nécrose tumorale α, tels que l'arthrite rhumatoïde, l'arthrose, la septicémie, le SIDA, la colite ulcéreuse, la sclérose en plaques, la maladie de Crohn et la perte de cartilage dégénérative.
Patent EP-1146853-A2 (EP)
Inventor: MUELLER ANGELA
IPC: A61K8/30
Filed: 2000-01-21
Abstract: The invention relates to an antioxidant combination from tocopherol and/or tocopherol ester, a gallic acid ester and a tea plant extract. The inventive combination is characterized by a much more potent antioxidant effect as compared to the individual components. The antioxidant combination is excellent for use in the production of skin care products which prevent oxidative damages to the skin or which improve the appearance of aged skin.
Patent EP-1165504-A2 (EP)
Inventor: FOWLER KERRY
IPC: C07D295/12
Filed: 2000-04-03
Abstract: The present invention is directed to compounds that bind to a novel regulatory site in the I domain of LFA-1, and thereby inhibit LFA-1 binding to ICAMs that bind LFA-1. The present invention therefore also provides methods to regulate leukocyte adhesion to endothelial cells. Compounds of the ivnention are useful for the treatment of pathologies, such as those associated inflammatory diseases, autoimmune diseases, tumor metastasis, allograft rejection and reperfusion injury. In particular, the present invention is directed to diaryl sulfides of general structural formula (I), a pharmaceutically acceptable salt, or prodrug thereof, and to the use of diaryl sulfides, and particularly compounds of formula (I), to inhibit LFA-1 binding to an ICAM that binds LFA-1 wherein A and B, independently, are aryl groups selected from the group consisting of 5- and 6-membered aromatic rings, including, but not limited to, phenyl, thienyl, furyl, pyrimidinyl, imidazolyl, pyrazolyl, pyridyl, pyrazinyl, pyrrolyl, and pyridazinyl.
Patent EP-1212868-A2 (EP)
Inventor: BERGENWALL MARTIN
IPC: H04L29/06
Filed: 2000-04-17
Abstract: L'invention concerne plusieurs paquets de données reçus et acheminés par un routeur (1) dans un réseau de données. Ce routeur (1) comporte des moyens de stockage (11) afin de stocker une liste préétablie de règles, en vue de détecter des paquets de données spéciaux, des moyens de détection (12) permettant de déceler des paquets de données spéciaux parmi les paquets de données reçus, en fonction de la liste préétablie de règles conservée dans lesdits moyens de stockage (11), et enfin des moyens d'acheminement (13) afin de demander des instructions concernant les paquets de données spéciaux détectés par lesdits moyens de détection (12) et pour acheminer ces paquets de données spéciaux conformément aux instructions reçues sur demande. La présente invention propose une architecture de service perfectionnée pour la nouvelle génération de réseau. Dans cette architecture de service, les fonctions des moyens de détection (12) et des moyens d'acheminement (13) peuvent être réalisés grâce à un déclencheur de service et une logique de service, de manière respective.
Patent EP-1178804-A2 (EP)
Title: Use of topical azathioprine to treat inflammatory bowel disorders
Inventor: SANBORN WILLIAM J
IPC: A61K9/12
Filed: 2000-04-27
Abstract: A method is provided to treat inflammatory bowel disease or to prevent the recurrence of colorectal adenomas following endoscopic removal by topically administering to the colon an effective amount of azathioprine or a pharmaceutically acceptable salt thereof, preferably via formulations adapted for delayed-release oral or rectal administration.
Patent EP-1173725-A2 (EP)
Inventor: TEUCHERT WOLF D DR
IPC: G01C11/02
Filed: 2000-04-14
Abstract: Bei einem Verfahren zur Bildaufnahme eines überflogenen Geländes (2), wobei von einem überflogenen Geländebereich (6a; 6b; 6c) zeitlich nacheinander mehrere Einzelbilder elektro optisch aufgenommen und digital gespeichert werden, die zu einem Gesamtbild des Geländebereiches (6a; 6b; 6c) zusammengesetzt werden, nehmen die Einzelbilder den aufzunehmenden Geländebereich (6a; 6b; 6c) jeweils vollflächig aber mit unterschiedlichen Lücken (8) behaftet auf und werden für das Gesamtbild des Geländebereichs (6a; 6b; 6c) mindestens zwei Einzelbilder anhand übereinstimmender Bildabschnitte (11) digital überlagert. Dazu wird eine photogrammetrische Kamera (1) mit mindestens einer Detektorgruppe (4a; 4b; 4c) eingesetzt, die mehrere voneinander jeweils beabstandete Detektoren (7) aufweist, wobei, gesehen in Flugrichtung (3), mindestens ein Detektor (7) die Lücke (8) zwischen zwei in Querrichtung beabstandeten, benachbarten Detektoren (7) zumindest teilweise abdeckt.
Patent EP-1206276-A2 (EP)
Inventor: INGENITO EDWARD P
IPC: A61M31/00
Filed: 2000-08-23
Abstract: The invention provides use of a physiologically acceptable composition comprising one or more polypeptide growth factors or one or more biologically active fragments thereof for the manufacture of a medicament for use in promoting fibrosis in a portion of a collapsed region of a lung in the course of a non-surgical lung volume reduction procedure. The invention also provides a physiologically acceptable composition comprising a polypeptide growth factor and (a) fibrinogen or (b) a fibrin monomer or (c) a fibrinogen activator.
Patent EP-1303844-A2 (EP)
Inventor: TALANIS THOMAS
IPC: G06F9/46
Filed: 2000-06-28
Abstract: A system and a method for transmitting data between a local data processing system and a remote data processing system through an asynchronous transmission channel. To ensure synchronization between a local and a remote data processing device, it is proposed that when a first program of the local data processing device sends a call, such as a RPC (Remote Procedure Call) to a second program of the remote data processing device, at least one predefinable parameter of the data to be transmitted is stored in the local data processing device. When the remote data processing device sends a response to the local data processing device, the predefinable parameter is provided to identify and/or synchronize the response in the first program.
Patent EP-1144303-A2 (EP)
Inventor: KHATCHATRIAN ROBERT G
IPC: A46B15/00
Filed: 2000-09-15
Abstract: La présente invention concerne des formes variées de générateur d'ozone comportant des moyens de décharge et un écran réflecteur, ainsi que des méthodes relatives à leurs applications. Les moyens de décharge sont constitués d'un élément diélectrique de surface rugueuse, avec une ouverture centrale de section rectangulaire, inséré entre des première et seconde électrodes. La première électrode est constituée de plusieurs enroulements hélicoïdaux en contact avec plusieurs rebords de l'élément diélectrique et la seconde électrode est constituée d'un revêtement électriquement conducteur qui recouvre la surface rugueuse de l'élément diélectrique. Une des formes du générateur d'ozone possède une unité centrale et deux unités latérales, les deux unités latérales pouvant être tournées afin de prendre différentes formes. On peut utiliser les formes variées du générateur d'ozone aux fins de désodorisation de locaux, de rafraîchissement de vêtements et de désodorisation de chaussures. D'autres applications de ces formes variées de générateur d'ozone comprennent le traitement et le maintien du cheveu et du poil d'animaux, la désodorisation de locaux et de chaussures. Dans ces formes variées de générateur d'ozone, il est possible d'utiliser d'autres formes d'électrodes, y comprises des électrodes en forme d'anneau et de plaque avec un bout pointu et des électrodes en forme de filament et de plaque avec une fente allongée.
Patent EP-1221956-A2 (EP)
Title: Transplantation de cellules souches (msc) de moelle osseuse autologues en vue de la regeneration myocardique
Inventor: CHIU RAY C J
IPC: A61K35/28
Filed: 2000-09-28
Abstract: La présente invention concerne un procédé permettant d'améliorer la fonction cardiaque d'un patient souffrant d'insuffisance cardiaque sans provoquer de réponse immunitaire et sans sacrifier le muscle squelettique du patient. Ce procédé consiste à transplanter des cellules souches de moelle osseuse (MSC) autologues dans le myocarde du patient pour faire croître de nouvelles fibres musculaires. En outre, ce procédé peut consister à utiliser une technique de marquage cellulaire pour confirmer la survie et la différentiation des cellules MSC implantées, et pour identifier le phénotype de ces cellules MSC par à la fois des marqueurs morphologiques et moléculaires. Par ailleurs, ce procédé peut consister à examiner les effets du micro-environnement des cellules MSC implantées sur leur différentiation et sur l'expression du phénotype. Enfin, ce procédé peut consister à examiner la contribution fonctionnelle des cellules MSC implantées dans un segment ischémique du myocarde.
Patent EP-1218840-A2 (EP)
Title: Computerized auction system using multiple purchase media
Inventor: JACK JOHN M
IPC: G06Q10/08
Filed: 2000-09-21
Abstract: Systems and methods create and maintain an auction server operative to receive requests for displaying auction items. The bid values are displayed and received in units that are specific to a particular program in which the user is participating. Bid values can be displayed and received in differing units depending on the particular program. Thus, participants in different programs can bid on the same items using different media types or different currencies. The system automatically converts between the different media types in order to determine highest bidders and bid amounts.
Patent EP-1242582-A2 (EP)
Inventor: VON LINTIG JOHANNES
IPC: A61P35/00
Filed: 2000-12-27
Abstract: La présente invention concerne des moyens et des procédés permettant de transformer des bactéries, des champignons y compris des levures, des cellules animales et végétales, des graines, des tissus et des plantes entières afin d'obtenir des transformants capables d'exprimer de nouvelles β-carotène dioxygénases et d'accumuler des métabolites importants de la voie carotène/rétinoïde tels que l'aldéhyde de la vitamine A et l'acide rétinoïque.  L'invention se rapporte également à des moyens et à des procédés permettant de produire des rétinoïdes par la biotechnique à l'aide de cellules, tissus, organes ou organismes entiers qui, sans transformation ou après transformation, accumulent la β-carotène ou absorbent la β-carotène du milieu.  L'invention se rapporte à des molécules d'ADN qui codent symétriquement et coupent asymétriquement les β-carotène dioxygénases dérivées de différentes sources, à des groupes taxonomiques d'organismes vivants conçus pour permettre la mise en oeuvre du procédé de l'invention, et à des plasmides ou des systèmes vecteurs comprenant les molécules précitées.  L'invention concerne enfin des bactéries, des champignons y compris des levures, des cellules animales et végétales, des graines, des tissus et des plantes entières transgéniques dotés d'une qualité nutritionnelle ou d'un état physiologique amélioré et qui contiennent les molécules d'ADN précitées et/ou qui ont été produits par utilisation des procédés de l'invention.