Patent RU-2418800-C2 (RU)
Title: Pyrrolo[2,3-b]pyridine derivative as protein kinase inhibitors
Inventor: IBRAKHIM PRABKHA N
IPC: C07D209/08
Filed: 2006-06-21
Granted: 2011-05-20
Abstract: FIELD: chemistry. 
     SUBSTANCE: invention describes a compound of structural formula IIIm:   or pharmaceutically acceptable salt thereof, where: R 81  is selected from a group comprising hydrogen, halogen, possibly substituted C 1 - 6 alkyl, possibly substituted C 2 - 6 alkenyl, possibly substituted C 2 - 6 alkynyl, possibly substituted cycloalkyl, possibly substituted heterocycloalkyl, possibly substituted aryl, possibly substituted heteroaryl, -OH, -NH 2 , -CN, -NO 2 , -C(O)OH, -S(O) 2 NH 2 , -C(O)NH 2 , -C(S)NH 2 , -NHC(O)NH 2 , -NHC(S)NH 2 , -NHS(O) 2 NH 2 , -OR 68 , -SR 68 , -NR 69 R 68 , -C(O)R 68 , -C(S)R 68 , -C(O)OR 68 , -C(O)NR 69 R 68 , -C(S)NR 69 R 68 , -S(O) 2 NR 69 R 68   ;  -NR 69 C(O)R 68 , -NR 69 C(S)R 68 , -NR 69 S(O) 2 R 68 , -NR 69 C(O)NH 2 , -NR 69 C(O)NR 69 R 68 , -NR 69 C(S)NH 2 , -NR 69 C(S)NR 69 R 68 , -NR 69 S(O) 2 NH 2 , -NR 69 S(O) 2 NR 69 R 68 , -S(O)R 68  and -S(O) 2 R 68 , R 83  is selected from a group comprising hydrogen, fluro and chloro; R 112  is selected from a group comprising possibly substituted C 2-6 alkyl, possibly substituted aryl, possibly substituted heteroaryl and -NR 79  R 80 ; R 68  is selected from a group comprising possibly substituted C 1-6 alkyl, possibly substituted C 2-6 alkenyl, but provided that when R 68  is possibly substituted C 2-6 alkenyl, then one of its alkene carbons is not bonded with N, S, O, S(O), S(O) 2 , C(O) or C(S) from -OR 68 , -SR 68 , -NR 69 R 68 , -C(O)R 68 , -C(S)R 68 , -C(O)OR 68 , -C(O)NR 69 R 68 , -C(S)NR 69 R 68 , -S(O) 2 NR 69 R 68 , -NR 69 C(O)R 68 , -NR 69 C(S)R 68 , -NR 69 S(O) 2 R 68 , -NR 69 C(O)NH 2 , -NR 69 C(O)NR 69 R 68 , -NR 69 C(S)NH 2 , -NR 69 C(S)NR 69 R 68 , -NR 69 S(O) 2 NH 2 , -NR 69 S(O) 2 NR 69 R 68 , -S(O)R 68  or -S(O) 2 R 68 , possibly substituted C 2-6 alkynyl, but provided that when R 68  is possibly substituted C 2-6 alkynyl, then one of its alkyne carbons is not bonded with N, S, O, S(O), S(O) 2 , C(O) or C(S) from -OR 68 , -SR 68 , -NR 69 R 68 , -C(O)R 68 , -C(S)R 68 , -C(O)OR 68 , -C(O)NR 69 R 68 , -C(S)NR 69 R 68 , -S(O) 2 NR 69 R 68 , -NR 69 C(O)R 68 , -NR 69 C(S)R 68 , -NR 69 S(O) 2 R 68 , -NR 69 C(O)NH 2 , -NR 69 C(O)NR 69 R 68 , -NR 69 C(S)NH 2 , -NR 69 C(S)NR 69 R 68 , -NR 69 S(O) 2 NH 2 , -NR 69 S(O) 2 NR 69 R 68 , -S(O)R 68  or -S(O) 2 R 68 , possibly substituted cycloalkyl, possibly substituted heterocycloalkyl, possibly substituted aryl and possibly substituted heteroaryl; R 69  is selected from a group comprising hydrogen and possibly substituted C 1-6 alkyl; and R 79  and R 80  independently denote hydrogen or possibly substituted C 1-6 alkyl or R 79  and R 80  together with the nitrogen atom to which they are bonded form a possibly substituted 5-7-member heterocycloalkyl. Described also is a composition and a set for modulating protein kinase based on said compounds and use of said compounds in preparing a medicinal agent. 
     EFFECT: novel compounds which are active towards protein kinase are obtained and described. 
     71 cl, 59 ex