Patent SG-11201909368T-A (SG)
Title: Compositions and systems for renal function determination
Inventor: DEBRECZENY MARTIN P
IPC: A61K49/00
Filed: 2018-10-26
Abstract: WO 19/08 4475 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 02 May 2019 (02.05.2019) WIPO I PCT 11111111111111011111111111111110111110101111111111111111111111111111111111111011110111111 (10) International Publication Number WO 2019/084475 Al (51) International Patent Classification: A 61K 49/00 (2006.01) CO7D 241/20 (2006.01) A61P 13/12 (2006.01) (21) International Application Number: PCT/US2018/057820 (22) International Filing Date: 26 October 2018 (26.10.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/577,962 27 October 2017 (27.10.2017) US (71) Applicant: MEDIBEACON INC. [US/US]; 1100 Como- rate Square Drive, Helix Center, Suite 175, St. Louis, Mis- souri 63132 (US). (72) Inventors: DEBRECZENY, Martin P.; 1100 Corporate Square Drive, Helix Center, Suite 175, St. Louis, Missouri 63132 (US). RAJAGOPALAN, Raghavan; 5097 Neptune Drive, Solon, Ohio 44139 (US). DORSHOW, Richard B.; 11077 Niehaus Lane, St. Louis, Missouri 63146 (US). NEUMANN, William L.; 1100 Corporate Square Drive, Helix Center, Suite 175, St. Louis, Missouri 63132 (US). ROGERS, Thomas E.; 1100 Corporate Square Drive, He- lix Center, Suite 175, St. Louis, Missouri 63132 (US). (74) Agent: FLOREK, Erin M. et al.; Armstrong Teas- dale LLP, 7700 Forsyth Boulevard, St. Louis, Missouri 63105-1847 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, 1E, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (54) Title: COMPOSITIONS AND SYSTEMS FOR RENAL FUNCTION DETERMINATION (57) : The present disclosure relates to systems and methods for de- termining the renal glomerular filtration rate or assessing the renal function in a patient in need thereof. The system includes a computing device, a pow- 10 er supply, one or more sensors, and at least one tracer agent that fluoresces _,\ when exposed to electromagnetic radiation. The electromagnetic radiation is detected using the sensors, and the rate in which the fluorescence decreases in the patient is used to calculate the renal glomerular filtration rate in the patient. 10 FIG. 2 [Continued on next page] 20 _\ ,12 WO 2019/084475 Al I 0111 111111110111111 0111 11111 111 1101 II III 11111 VIII VIII VIII VIII EH 1111111111111111 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h))