Patent SG-11201907298W-A (SG)
Title: Methods and compositions for gene transfer across the vasculature
Inventor: ASOKAN ARAVIND
IPC: C12N15/861
Filed: 2018-02-15
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) CORRECTED VERSION (19) World Intellectual Property Organization International Bureau (43) International Publication Date 111111111111011010101111101111010 110111010111101110110011101110111 (10) International Publication Number WO 2018/152333 A9 23 August 2018 (23.08.2018) W 1 PO I PCT (51) International Patent Classification: C12N 15/861 (2006.01) C12N 7/04 (2006.01) C12N 15/34 (2006.01) 9618 48/00 (2006.01) C12N 7/00 (2006.01) C07K 14/00 (2006.01) C12N 7/02 (2006.01) (21) International Application Number: PCT/US2018/018381 (22) International Filing Date: 15 February 2018 (15.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/459,286 15 February 2017 (15.02.2017) US (71) Applicant: THE UNIVERSITY OF NORTH CAROLI- NA AT CHAPEL HILL [US/US]; 109 Church Street, Chapel Hill, North Carolina 27516 (US). (72) Inventors: ASOKAN, Aravind; 133 South Fields Circle, Chapel Hill, North Carolina 27516 (US). MURLIDHA- RAN, Giridhar; 23 Chestnut Way, Apartment 204, Quin- cy, Massachusetts 02169 (US). ALBRIGHT, Blake; 605 Jones Ferry Road, Apartment TT12, Carrboro, North Car- olina 27510 (US). (74) Agent: MILLER, Mary, L.; MYERS BIGEL, P.A., P.O. Box 37428, Raleigh, North Carolina 27627 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, — (54) Title: METHODS AND COMPOSITIONS FOR GENE TRANSFER ACROSS THE VASCULATURE Q ntification of Cortical Neuron Transduction 8 FIG. I (57) : The present disclosure provides AAV capsid proteins comprising a modification in the amino acid sequence and virus capsids and virus vectors comprising the modified AAV capsid protein. The disclosure also provides methods of administering the virus vectors and virus capsids of the disclosure to a cell or to a subject in vivo. [Continued on next page] WO 2018/152333 A9 IMEDIMOM0101011MOHOIOMOHIMMIIHOOMEICIO# MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) (48) Date of publication of this corrected version: 24 January 2019 (24.01.2019) (15) Information about Correction: see Notice of 24 January 2019 (24.01.2019)