baber/WOPTO huggingface dataset:
Patent CA-3135124-A1 (CA)
Inventor: MIHRANYAN ALBERT
IPC: C07K1/34
Filed: 2020-03-30
Abstract: The present invention provides method of removing particles from a feed fluid, the method comprising: passing the fluid through a first filtration medium having a thickness of from 5 to 20 µm, wherein passing the feed fluid through the first filtration medium provides a particle removal probability log10 reduction value (LRV) of greater than or equal to 1 for particles having a diameter of from about 10 to about 40 nm and a particle removal probability log10 reduction value (LRV) of greater than or equal to 3 for particles greater than about 40 nm in diameter; and passing the fluid through a second filtration medium having a thickness of from 20 to 70 µm (e.g. 20 to 45 µm)20 to 45 pm, wherein passing the feed fluid through the second filtration medium provides a particle removal probability log10 reduction value (LRV) of greater than or equal to 3 for particles having a diameter of from about 10 to about 40 nm and a particle removal probability log10 reduction value (LRV) of greater than or equal to 3 for particles having a diameter of greater than or equal to about 40 nm; so as to retain at least a portion of the particles on each medium to produce a filtrate containing a lower concentration of the particles than the feed fluid.
Patent CA-3135246-A1 (CA)
Inventor: TOOLAN DANIEL PATRICK
IPC: B66F11/00
Filed: 2021-10-21
Abstract: Il est décrit un appareil de levage de véhicule comprenant une base de levage, une tour de levage amovible et une plate-forme amovible. Un premier rail est configuré pour permettre le déplacement de la tour de levage à lhorizontale et comprend un rail extérieur extrudé fixé à la base de levage, des rails centraux extrudés se déplaçant en fonction des rails extérieurs extrudés et des rails intérieurs extrudés fixés à la tour de levage et se déplaçant en fonction des rails centraux extrudés. Un deuxième assemblage de rail est fixé à la tour de levage et peut permettre le déplacement à la verticale de la plate-forme par rapport à la tour de levage. Cet assemblage comprend un rail extérieur extrudé fixé à la tour de levage, des rails centraux extrudés se déplaçant en fonction des rails extérieurs extrudés et des rails intérieurs extrudés fixés à la tour de levage et se déplaçant par rapport aux rails centraux extrudés.
Patent CA-3135446-A1 (CA)
Inventor: ZHANG YU
IPC: G06Q20/22
Filed: 2021-10-22
Abstract: The present invention discloses to a payment code, relating to mobile application technology field, solving the problems of slow code scanning or unsuccessful code scanning, the method comprises:  accepting payment request, displaying payment code 1 in a preset position on the screen of first terminal, and at the same time activating front camera of the first terminal to obtain code scanning device image 1;  determining position 1 of the center of the code scanning device's camera in the image 1, wherein the center point of the image 1 coincides with the center point of the front camera of the first terminal; calculating position 2 in the first terminal's plane, wherein the plane is projected by position 1; displaying payment code 2 in the first terminal screen according to position 2.
Patent CA-3136404-A1 (CA)
Inventor: BRAUN ROLAND
IPC: G05B19/418
Filed: 2020-04-08
Abstract: The invention relates to an aggregating server (100) comprising a remote node input interface (103) configured to receive node images representing nodes in a remote address space (140); an address space description interface (101) configured to import node description information of nodes (150, 152, 154, 156) in the remote address space (140) to be aggregated; an aggregation module (107), configured to instantiate proxy nodes (104, 106, 108) based on the received node data of nodes in the remote address space (140); and a node filter (102) located between the remote node input interface (103) and the aggregation module (107), configured to filter the received node images from the remote node input interface (103) according to the imported node description information of nodes in the remote address space (140) to be aggregated.
Patent CA-3137811-A1 (CA)
Title: Codon optimized synthetic nucleotide sequences encoding cry2ai protein and uses thereof
Inventor: MANGENA GEETHA LAKSHMI
IPC: C07K14/325
Filed: 2020-04-20
Abstract: The present disclosure provides codon optimized synthetic nucleotide sequences encoding Bacillus thuringiensis (Bt) insecticidal crystal Cry2Ai protein having insecticidal activity against insect pests including, but not limited to insect pests belonging to the order Lepidoptera. The present disclosure also relates to expression of these sequences in plants. The disclosure further provides a DNA construct, a vector, and a host cell comprising the codon optimized synthetic nucleotide sequences of the invention. Also it provides use of the codon optimized synthetic nucleotide sequences for production of insect resistant transgenic plants, and a composition comprising Bacillus thuringiensis comprising the codon optimized synthetic nucleotide sequence of the present invention.
Patent CA-3139967-A1 (CA)
Inventor: INGLIS PETER DW
IPC: E21B19/086
Filed: 2019-07-31
Abstract: La présente invention concerne un outil de fond de trou ayant un appareil d'indexation destiné à actionner l'outil de fond de trou à partir de la surface en appliquant un nombre prédéterminé de signaux de pression hydraulique à l'outil de fond de trou. Le fond de trou a un tubage externe qui a une surface externe et une surface interne, la surface interne définissant une région interne du tubage externe. L'outil de fond de trou comprend un manchon coulissant positionné à l'intérieur de la région interne du tubage externe, le manchon coulissant pouvant coulisser par rapport au tubage externe. Le manchon coulissant comprend un premier aimant et un deuxième aimant qui sont positionnés dans une orientation opposée l'un par rapport à l'autre destinés à fournir un point de référence détectable par l'intermédiaire d'un magnétomètre au niveau d'une surface d'un puits de forage. Une position d'indexation de l'outil de fond de trou est déterminée en comparant un emplacement du point de référence sur le manchon coulissant avec un emplacement d'un point fixe sur le tubage externe.
Patent CA-3140333-A1 (CA)
Inventor: ZHAI XIAOQING
IPC: G06F9/44
Filed: 2021-11-24
Abstract: A microservice rate limiting method and apparatus, which provide finer granularity in complex query scenarios and involve: configuring rate-limiting priority levels for microservices provided by a microservice system; receiving an access application from a caller system, acquiring therefrom concurrency expectation and TPS expectation, for matching the corresponding rate-limiting priority level in the microservice; acquiring a microservice request from the caller system for pre-occupation determination, initiating formal pre-occupation, and returning a pre-occupation code to the caller system; determining, on the basis of the matched TPS threshold of the rate-limiting priority level as well as the pre-occupation code and the TPS pre-occupation counts, whether to apply TPS rate limiting to the current microservice request; and/or determining, on the basis of the matched concurrency threshold of the rate-limiting priority level and the concurrency counts of the current microservice request, whether to apply concurrency rate limiting to the current microservice request.
Patent CA-3143599-A1 (CA)
Title: Allogeneic t-cell-based hiv vaccine to induce cellular and humoral immunity
Inventor: GUMRUKCU SERHAT
IPC: A61K39/12
Filed: 2020-06-17
Abstract: Provided herein are methods for treating a patient with human immunodeficiency virus (HIV), comprising administering cellular compositions comprising recombinant allogeneic cells, such as CD4+ T cells. The present invention further relates to compositions and methods for making an allogeneic T-cell-based protective HIV vaccine that induces both cellular and humoral immunity.
Patent CA-3145613-A1 (CA)
Title: Composition for lowering blood glucose level, reducing blood hemoglobin a1c content, or increasing blood hdl-cholesterol content
Inventor: UCHIO Ryusei
IPC: A61P3/06
Filed: 2020-06-29
Abstract: One or more embodiments of the present invention provide a composition for improving lipid metabolism or carbohydrate metabolism, said composition containing a component derived from turmeric. One or more embodiments of the present invention pertain to a composition for lowering blood glucose level, reducing blood hemoglobin A1c content or increasing blood HDL-cholesterol content, a composition for treating or preventing metabolic syndrome or a composition for improving lipid metabolism or carbohydrate metabolism, said composition containing at least one selected from turmeronol A, turmeronol B and bisacurone as an active ingredient. The aforesaid composition can contain turmeronol A and turmeronol B in a total amount of 20 µg or more per daily intake, turmeronol A in an amount of 17 µg or more per daily intake, turmeronol B in an amount of 5 µg or more per daily intake, and bisacurone in an amount of 80 µg or more per daily intake.
Patent CA-3145924-A1 (CA)
Title: Extracellular vesicle linked to molecules and uses thereof
Inventor: ZHANG YI
IPC: A61K47/69
Filed: 2020-08-14
Abstract: The present disclosure relates to extracellular vesicles (e.g., exosomes) comprising a biologically active molecule covalently linked to the extracellular vesicle via an anchoring moiety, which may be useful as an agent for the prophylaxis or treatment of cancer or other diseases. Also provided herein are methods for producing the extracellular vesicles and methods for using the extracellular vesicles to treat diseases or disorders.
Patent CA-3149148-A1 (CA)
Inventor: KOBAYASHI YOSHIKAZU
IPC: B01J23/89
Filed: 2020-07-02
Abstract: Provided are a metal-supported catalyst that achieves both exceptional catalytic activity and exceptional durability, a battery electrode, and a battery. This metal-supported catalyst includes a carbon support, and platinum particles serving as catalyst metal particles supported on the carbon support. The platinum particles include pure platinum particles and platinum alloy particles. The proportion of the weight of the pure platinum particles relative to the total of the weight of the pure platinum particles and the weight of the platinum alloy particles is 15-61% inclusive. The ratio of the proportion of the nitrogen atom content relative to the carbon atom content measured according to elemental analysis in which a combustion method is used, and the proportion of the nitrogen atom content relative to the carbon atom content measured according to X-ray photoelectron spectroscopy, is 1.05 or higher.
Patent CA-3149324-A1 (CA)
Title: Polytherapie anticancereuse d'anticorps anti-galectine-9 et d'agents chimiotherapeutiques
Inventor: KOIDE SHOHEI
IPC: A61P37/02
Filed: 2020-08-03
Abstract: L'invention concerne une polythérapie contre une tumeur solide, comprenant un anticorps qui se lie à la galectine-9 humaine (anticorps anti-Gal9, par exemple, G9,2-17), et un ou plusieurs agents chimiothérapeutiques, par exemple la gemcitabine, le paclitaxel ou une combinaison de ceux-ci.
Patent CA-3150641-A1 (CA)
Title: Wire installation tool
Inventor: HUNTLEY THOMAS
IPC: H02G1/00
Filed: 2022-03-02
Abstract: An in-ground wire installation tool including a body having a concave-shaped side with a pointed edge; an opposing side including a channel configured to dispense a wire, the concave-shaped side and the opposing side being connected via a top portion and a bottom portion, the top portion including an attachment portion configured to house a shaft; and the bottom portion connecting the concave-shaped side and the channel, the bottom portion including a blade.
Patent CA-3151462-A1 (CA)
Title: Corps de gaine malleable
Inventor: KORKUCH CHRISTOPHER NASON
IPC: A61M60/00
Filed: 2020-09-28
Abstract: La présente invention concerne un ensemble pompe à sang qui comprend une gaine d'introduction (100) ayant une extrémité proximale et une extrémité distale, un corps de pompe (120) qui s'étend à l'intérieur de la gaine d'introduction, et un cathéter (121) qui est relié avec le corps de pompe et s'étend de manière proximale à travers la gaine d'introduction. Dans un état de repos, la gaine d'introduction forme une section transversale ovale dimensionnée pour englober le cathéter et un dispositif médical. Dans un état contraint, lorsque le corps de pompe est à l'intérieur de la gaine d'introduction, la section transversale de la gaine d'introduction est circulaire. La malléabilité de la gaine d'introduction permet de faire passer des dispositifs médicaux plus grands à travers la gaine d'introduction tout en permettant d'introduire d'autres dispositifs à travers la gaine d'introduction après que la pompe a été guidée. Le périmètre de section transversale ovale de la gaine d'introduction est égal au périmètre de la section transversale circulaire de la gaine d'introduction.
Patent CA-3154912-A1 (CA)
Title: Ligands selectifs pour agregats de proteine tau
Inventor: SOHN DANIEL DUNGAN
IPC: A61P25/28
Filed: 2020-10-15
Abstract: La présente invention concerne un composé de formule (I) et des compositions comprenant un composé de formule (I) ou un sel, ester, amide ou carbamate pharmaceutiquement acceptable de celui-ci, ou un sel d'un tel ester, amide ou carbamate. La présente invention concerne également un composé de formule (X) et des compositions comprenant un composé de formule (X) ou un sel, ester, amide ou carbamate pharmaceutiquement acceptable de celui-ci, ou un sel d'un tel ester, amide ou carbamate. La présente invention concerne en outre des utilisations des composés de formule (I) et (X) et des compositions comprenant des composés de formule (I) et (X), comprenant l'utilisation de tels composés et compositions pour le diagnostic et le traitement de maladies neurodégénératives, et en particulier des tauopathies telles que la maladie d'Alzheimer.
Patent CA-3158575-A1 (CA)
Inventor: BEN-ARI YEHEZKEL
IPC: A61K47/20
Filed: 2020-10-31
Abstract: The invention relates to a liquid oral formulation of bumetanide for the treatment of autism, more particularly for the improvement of the Autism Spectrum Disorder (ASD) core symptoms, tuberous sclerosis complex, fragile X syndrome, Rett syndrome, Down syndrome, cancer and particularly gliomas, spinal cord lesions, chronic pain, brain trauma, cerebrovascular infarcts, various types of epilepsies, and also acute lung injury such as pneumonias or Severe Acute Respiratory Disease due to Coronavirus-2 (SARS-CoV-2). Said formulation is especially designed for paediatric populations. The invention relates also to a posology for the administration of said liquid oral formulation.
Patent CA-3159260-A1 (CA)
Title: Prosthetic heart valve
Inventor: LEVI TAMIR S
IPC: A61F2/95
Filed: 2015-05-07
Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. The prosthetic valve can comprise an annular frame, leaflets, an inner skirt, and an outer skirt. The outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack that buckles outward radially when the valve is in the expanded configuration and which lies flat when the valve is in the collapsed configuration. In some embodiments, the outer skirt is stiffer in the axial direction of the valve than in the circumferential direction of the valve. In additional embodiments, the outer skirt comprises a self-expandable fabric comprising fibers made of a shape memory material having a shape memory set to enhance the radially outward buckling of the outer skirt. Methods of crimping such valves to a collapsed or partially collapsed configuration are also disclosed.
Patent CA-3164592-A1 (CA)
Inventor: DIAZ LUIS ALBERTO
IPC: A61P37/04
Filed: 2021-01-13
Abstract: Dans certains modes de réalisation, la présente invention concerne des méthodes utiles pour le traitement de cancers avec MMR fonctionnelle et/ou stabilité microsatellitaire (MSS) et également utiles pour améliorer l'immunogénicité de cellules cancéreuses avec MMR fonctionnelle et/ou stabilité microsatellitaire (MSS), améliorer la sensibilité de cellules cancéreuses avec MMR fonctionnelle et/ou stabilité microsatellitaire (MSS) au blocage des points de contrôle immunitaires, induire une signature mutationnelle de MMR déficiente dans des cellules cancéreuses avec MMR fonctionnelle et/ou stabilité microsatellitaire (MSS), et/ou accroître la fréquence des mutations faux-sens et InDel dans des cellules cancéreuses avec MMR fonctionnelle et/ou stabilité microsatellitaire (MSS). Dans certains modes de réalisation, ces méthodes impliquent l'administration d'une combinaison de témozolomide et de cisplatine, ou une combinaison de témozolomide, de cisplatine et d'un inhibiteur des points de contrôle immunitaires, à un sujet en ayant besoin.
Patent CA-3170113-A1 (CA)
Inventor: CAMERON-DONALD KATE ELIZABETH
IPC: B64D11/00
Filed: 2021-02-18
Abstract: A multi-layer sleeping compartment for an aircraft is provided in order to more comfortable accommodate passengers to recline and sleep. The multilayer compartment houses a plurality of sleeping pods arranged either side of an entrance, and the sleeping compartment is generally aligned with a longitudinal axis of the aircraft. Further the pods may be booked for session times during the normal flight of an aircraft.
Patent CA-3170920-A1 (CA)
Inventor: ROBERTSON BRIAN
IPC: A01F12/28
Filed: 2021-04-27
Abstract: The invention comprises an automated, dynamic cover plate system, which may be quickly attached, detached and adjusted to the exterior of a concave grate of a combine harvester in order to adjust the flow characteristics of the concave or separator grate assemblies. The automated, dynamic cover plate system improves the threshing capability of the rasp bar threshing cylinder while simultaneously capturing additional threshed grain. The automated, dynamic cover plate system of the present invention is designed to be controlled, either manually or automatically, by the operator of the combine harvester or by a computerized or automated intelligence system.
Patent CA-3172835-A1 (CA)
Inventor: ZWEIG ANDREW MICHAEL
IPC: C08G59/22
Filed: 2021-03-05
Abstract: Aspects of the present disclosure relate to Schiff base oligomers and uses thereof. In at least one aspect, an oligomer is represented by Formula (I) wherein each instance of R4, R5, R6, R7, R8, R10, R11, R12, R13, and R14 is independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkoxyl, aryloxyl, ether, and heterocyclyl. Each instance of R9 of Formula (I) is independently selected from the group consisting of alkyl, cycloalkyl, aryl, heterocyclyl, and ether. Each instance of R28 and R29 of Formula (I) is independently selected from the group consisting of hydrogen, alkyl, and aryl. Each instance of R33 of Formula (I) is independently selected from the group consisting of alkyl, cycloalkyl, aryl, heterocyclyl, and a bond. Each instance of R41 of Formula (I) is independently -NH- or a bond and each instance of R40 is independently -NH- or -NH-NH-.
Patent CA-3173443-A1 (CA)
Inventor: TWESTEN CHRISTOPH
IPC: G16H50/70
Filed: 2021-04-16
Abstract: La présente invention concerne un procédé de détermination d'une ligne de base dans une courbe de glycémie, un procédé de détermination d'une réponse à la glycémie d'un individu à au moins un facteur d'impact, un procédé de prédiction du nutritype d'un individu, un procédé de prédiction de la réponse à la glycémie d'un individu à au moins un facteur d'impact, un procédé pour déterminer des recommandations de style de vie personnalisées pour un individu, ainsi qu'un procédé pour déterminer la composition d'un régime personnalisé et son procédé de préparation.
Patent CA-3174486-A1 (CA)
Inventor: BOTHMER ANNE HELEN
IPC: C12N15/90
Filed: 2021-03-04
Abstract: Methods and compositions for modulating a target genome are disclosed.
Patent CA-3179025-A1 (CA)
Inventor: LARSEN NIKOLAS A
IPC: C10G75/00
Filed: 2022-10-11
Abstract: Systems and methods for enhancing the processing of hydrocarbons in a FCC unit by introduction of the coked FCC catalyst from the FCC reactor and a renewable feedstock to the FCC regenerator to facilitate regeneration of the coked FCC catalyst. The renewable feedstock can contain biomass-derived pyrolysis oil. The biomass-derived pyrolysis oil and coke from the coked FCC catalyst are oxidized by oxygen to provide a regenerated catalyst that is recycled to the FCC reactor.
Patent CA-3183434-A1 (CA)
Title: Tki du egfr destines a etre utilises dans le traitement du cancer du poumon non a petites cellules
Inventor: RUKAZENKOV YURI
IPC: A61P35/00
Filed: 2021-05-26
Abstract: L'invention concerne des inhibiteurs de tyrosine kinase (TKI) du récepteur du facteur de croissance épidermique (EGFR), destinés à être utilisés dans le traitement adjuvant après résection tumorale de patients atteints d'un cancer du poumon non à petites cellules (CPNPC) positif aux mutations du récepteur du facteur de croissance épidermique (EGFRm).
Patent CA-3184170-A1 (CA)
Title: Process for the preparation of ticagrelor
Inventor: SZEPINSKI EMIL
IPC: C07D487/04
Filed: 2021-06-04
Abstract: The present invention relates to a process for the preparation of ticagrelor, which provides a product of high purity, in particular, with no detectable levels of Nnitrosmine impurities. The process comprises a first step of treating 2- [[(3aR,4S,6R,6aS)-6-[[5-amino-6-chloro-2-(propylthio)-4-pyrimidinyl]amino]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol starting material with sodium nitrite, followed by acidic washing; in a second step, the 2-[[(3aR,4S,6R,6aS)-6-[7-chloro-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H- cyclopenta-1,3-dioxol-4-yl]oxy]ethanol obtained in the previous step is coupled with trans-(1 fl,2S)-2-(3,4-difluorophenyl)cyclopropylamine, and the reaction is followed by a first washing at basic pH a second washing at acidic pH; and in an third step, the compound obtained in the previous step is deprotected by treatment with mineral acid, followed by acidic washing.
Patent CA-3184200-A1 (CA)
Title: Reformage a la vapeur
Inventor: BABOVIC MILETA
IPC: C01B3/38
Filed: 2021-07-22
Abstract: L'invention concerne un procédé de reformage à la vapeur d'une charge d'hydrocarbures contenant un ou plusieurs composés azotés, consistant à faire passer un mélange de la charge d'hydrocarbures et de la vapeur d'eau à travers un lit de catalyseur constitué d'un ou plusieurs catalyseurs de reformage à la vapeur de nickel disposés à l'intérieur d'une pluralité de tubes chauffés de l'extérieur dans un reformeur à la vapeur tubulaire, chaque tube comprenant une entrée à travers laquelle est introduit le mélange d'hydrocarbure et de vapeur d'eau, une sortie à partir de laquelle est récupéré un gaz reformé contenant de l'hydrogène, du monoxyde de carbone, du dioxyde de carbone, de la vapeur d'eau, de l'ammoniac et du méthane, et le catalyseur de reformage à la vapeur au moins à la sortie des tubes étant un catalyseur de reformage à la vapeur de type coquille d'?uf particulaire comprenant de 2,5 à 9,5 % en poids de nickel, sous la forme de NiO, le nickel étant présent dans une couche à la surface du catalyseur et l'épaisseur de la couche étant située dans la plage allant de 100 à 1 000 µm.