baber/WOPTO huggingface dataset:
Patent CR-20110623-A (CR)
Title: Moduladores de gpr 119
Inventor: MASCITTI VINCENT
IPC: A61K31/4545
Filed: 2011-11-24
Abstract: En la presente memoria se describen compuestos de Fórmula I que modulan la actividad del receptor acoplado a proteína G GPR119 y sus usos en el tratamiento de enfermedades ligadas a la modulación del receptor acoplado a proteína G GPR119 en animales.
Patent CR-20160276-A (CR)
Title: "piperidiniltetrahidroquinolinas sustituidas y su uso como antagonistas de los adenoreceptores alpha-2c"
Inventor: KAST RAIMUND;
IPC: C07D417/14
Filed: 2014-12-16
Abstract: La presente solicitud se relaciona con nuevas piperidiniltetrahidroquinolinas sustituidas, con procesos para su preparación, con su uso para el tratamiento y/o prevención de enfermedades y con su uso para preparar medicamentos para el tratamiento y/o prevención de enfermedades, en particular para el tratamiento y/o prevención de microangiopatías diabéticas, úlceras diabéticas de las extremidades, en particular para promover el curado de heridas de úlceras de pie diabético, falla cardiaca diabética, trastornos cardiacos microvasculares coronarios diabéticos, trastornos vasculares periféricos y cardiacos, trastornos tromboembolíticos e isquemias, trastornos de la circulación periférica, fenómeno de Raynaud, síndrome de CREST, trastornos microcirculatorios, claudicación intermitente, y neuropatías periféricas y autónomas.
Patent CR-20160600-A (CR)
Title: Quinolizione derivados como inhibidores pi3k
Inventor: KUJLKARNI SANJEEV ANANT
IPC: C07D519/00
Filed: 2015-07-01
Abstract: Se divulgan compuestos de la fórmula I, sus formas tautoméricas, estereoisómeros y sales farmacéuticamente aceptables de los mismos, en donde R1-R4 y n son como se define en la descripción, las composiciones farmacéuticas incluyen un compuesto, tautómero, estereoisómero o sal del mismo, y métodos para el tratamiento o prevención de enfermedades o trastornos, por ejemplo, cáncer, que son susceptibles de tratamiento o prevención inhibiendo la enzima PI3K de un sujeto
Patent CR-20170236-A (CR)
Title: Método para producir sistema de administración farmacéutica, uso de carbonato de calcio y sistema de administración farmacéutica obtenido por método
Inventor: PUCHKOV MAXIM
IPC: A61K31/167
Filed: 2015-12-16
Abstract: La presente invención se refiere a un método para la producción de un sistema de administración farmacéutica, al uso de un carbonato de calcio reaccionado en superficie para mejorar la friabilidad de un sistema de administración farmacéutica al igual que para mejorar la capacidad de flujo de un sistema de administración farmacéutica, y a un sistema de administración farmacéutica obtenido por el método
Patent CR-20170542-A (CR)
Title: ALCOHOLES TRIFLUMETÍLICOS COMO MODULADORES DE RORyT (Divisional 2017-0166)
Inventor: KINZEL OLAF
IPC: C07D487/08
Filed: 2015-10-30
Abstract: La presente invención comprende compuestos de la Fórmula I, en donde: X, A1, A2, A3, A4, R1, R2 y R3 se definen en la especificación. La invención comprende, además, un método para tratar o mejorar un síndrome, un trastorno o una enfermedad, en donde el síndrome, el trastorno o la enfermedad son artritis reumatoide o soriasis. La invención comprende, además, un método para modular la actividad de ROR¿t en un mamífero por medio de la administración de una cantidad terapéuticamente eficaz de al menos un compuesto de acuerdo con la reivindicación 1.
Patent CR-20190593-A (CR)
Title: Antibody molecules to cd73 and uses thereof
Inventor: SABATOS-PEYTON CATHERINE ANNE
IPC: A61K39/40
Filed: 2018-06-21
Abstract: Antibody molecules that bind to CD73 are disclosed. The anti-CD73 antibody molecules can be used to treat, prevent and/or diagnose cancer.
Patent CR-20200601-A (CR)
Title: Dll3-cd3 bispecific antibodies
Inventor: SCHEER JUSTIN
IPC: C07K16/28
Filed: 2019-06-07
Abstract: <p>The present disclosure relates to DLL3-CD3 bispecific antibodies, characterized by their sequences. The application further relates to uses of the antibodies and their compositions, in particular for therapeutic purposes in the field of cancer diseases.</p>
Patent EC-SP055742-A (EC)
Title: Nuevo método para la síntesis industrial de diéster de metilo del ácido 5-amino-3-carboximetil-4-ciano-2-tiofencarboxílico y aplicación para la síntesis de sales bivalentes de ácido ranélico y sus hidratos
Inventor: LECOUVE JEAN-PIERRE
IPC: C07D333/40
Filed: 2005-04-22
Abstract: Proceso para la síntesis industrial del compuesto de fórmula (I): Aplicación a la síntesis de sales bivalentes de ácido ranélico y más específicamente de ranelato de estroncio y sus hidratos.
Patent EC-SP066584-A (EC)
Title: Procedimiento para la producción de una composición farmacéutica sólida de administración oral
Inventor: BENKE KLAUS
IPC: A61K31/5377
Filed: 2006-05-25
Abstract: La presente invención trata de un procedimiento para la producción de una composición farmacéutica sólida de administración oral que contiene 5-cloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morfolinil)-fenil]-1,3-oxazolidin-5-il}-metil)-2-tiofencarboxamida en forma hidrofilizada, así como de su uso para prevenir y/o tratar enfermedades.
Patent EC-SP930896-A (EC)
Title: Aparato de control remoto automatizado y metodo para esmerilar bandas de caucho usadas para compactar papel y otros materiales de tejido
Inventor: HEIM ALBERT
IPC: B24B21/04
Filed: 1993-01-05
Abstract: El presente invento es aplicable a aparatos de esmerilado para remover irregularidades, nivelar la superficie de trabajo de bandas de caucho gruesas, de gran ancho usadas para compactar papel o (en el caso de tela, pre-encoger) tejidos fibrosos; y el control de dichos aparatos de esmerilado. El presente invento permite el esmerilado durante el uso en producción de una banda cuando el ambiente cercano a (encima de) la banda es contrario al control de esmerilado visual por personal debido a la alta temperatura y vapor. Medios censores y de control colocados remotamente desde la superficie de trabajo de la banda permiten a un operador el controlar más precisamente que si se hiciera visualmente y sin exponer al operador a adversamente peligrosas condiciones de trabajo.
Patent EC-SP972259-A (EC)
Title: Procedimientos e intermedios para preparar derivados decromanol sustituidos
Inventor: PISCOPIO ANTHONY DANIEL
IPC: C07D311/04
Filed: 1997-09-16
Abstract: La invención se refiere a procedimientos para preparar un compuesto de la fórmula: (gráfico), y el enantiómero de dicho compuesto, en la que el radical de ácido benzoico está unido a la posición 6 ó 7 del anillo de cromano y R1, R2 y R3 son como se define en este documento. La invención se refiere además a intermedios que son útiles en la preparación del compuesto de fórmula X anterior.
Patent FI-20001488-A (FI)
Inventor: VATANEN HARRI
IPC: H04L12/56
Filed: 2000-06-21
Abstract: A method and system for the handling of a transaction request sent to a server from a terminal device over a telecommunication network, where the transaction request includes identifying data of the requester, identifying data of a utilized network component, and the digital signature of the requester. In response to the transaction request, a transaction message is sent from the server to the terminal device and/or to identified utilized network component. Message-type data and subscriber data are appended to the transaction message before it is sent by the server. The appended message-type data and subscriber data are then extracted from the transaction message in the telecommunication network and are used as handling data for carrying out and otherwise in connection with the transaction.
Patent FI-20136094-A (FI)
Inventor: ETEMAD KAMRAN
IPC: H04W4/90
Filed: 2013-11-06
Abstract: Embodiments of user equipment (UE) and method for handover enhancement using reference signal received quality (RSRQ) in a wireless network are generally described herein. In some embodiments, a UE adaptively selects handover initiation parameters based, at least in part, on a velocity of the UE. The UE may determine an RSRQ of a serving cell and an RSRQ of a target cell and may transmit a measurement report to a serving eNB for handover from the serving cell to the target cell when the target cell RSRQ exceeds the serving cell RSRQ in accordance with the selected handover initiation parameters. In some of these embodiments, the handover initiation parameters may include an offset value, such as an A3offset value, and a time-to-trigger (TTT) that comprise an A3offset-TTT pair.
Patent GB-1050563-A (GB)
IPC: F24F7/02
Abstract: 1,050,563. Ventilators. WESTERN ENGINEERING & MANUFACTURING CO. Jan. 11, 1965, No. 1251/65. Heading F4V. A roof ventilator 10 comprises a pair of doors 16 hinged to a base 12 and further connected to a cross-member 38 of the base by pairs of telescopic hinge arms 18 and 20, and thrust arms 22 and pistons 52 biased by springs 24 to open the doors when released from engagement with release arms 26. For each door the piston 52 moves within arm 18 and a roller 56 on the thrust arm is adapted to engage a hooked portion 54 of the release arm. The door may be opened by manual action on the door itself and the arrangement is such that when the door reaches a partially open position the hinge arms are at such an angle that the roller 56 is released from the hook 54 so that the action of spring 24 fully opens the door. In the event of an explosion inside the building the pressure of expanding gases acts on the door to open the ventilator in similar manner. The door may also be opened manually by pulling on a chain 80 attached to the release arm 26 to free the thrust arm. In the event of a fire inside the building a fusible link 100, Fig. 1 (not shown), melts, allowing a spring-loaded plate 84 to fall and operate the release arms 26.
Patent GB-1052054-A (GB)
IPC: B29C70/68
Abstract: 1,052,054. Encapsulating electrical units. CONSOLIDATED ELECTRODYNAMICS CORPORATION. May 28, 1963, No. 32562/66. Divided out of 1,052,052. Heading B5A. In a method of forming an encapsulated electrical unit, a plurality of electrical components are assembled on a printed circuit board; a plurality of terminals are mounted on, and projecting from, the board; the terminals are fastened to a plate of moulding die; encapsulating compound is cast in the die around the whole assembly except the portions of the terminals which abut the die plate; and the encapsulated unit is removed from the die, the said portions of the terminals being exposed at the surface of the unit. As shown, Fig. 7, a printed circuit board 41 has components 40 mounted on one side thereof, and on the other side terminals 43 in the form of knurled studs having planar end faces remote from the board and internal threaded bores by means of which the assembly is fixed by bolts 50 to a die plate 47. A two-piece box-shaped portion 53 co-operates with plate 47 to form a die 52, through an opening 61 in which a casting compound is admitted. When the die is removed terminals 43 lie flush at the surface of the encapsulated unit. In another embodiment, Figs. 9-13 (not shown), two toroidal transformer cores 75, 76, each carrying a primary winding, are partially embedded, together with a plurality of terminals 43 and two potentiometers 72, 73, in a front panel 64 in a first casting step. A printed circuit board assembly 92 comprising a plurality of components and further terminals is mounted on panel 64, the whole assembly then being placed in a mould 95, Figs. 14-16 (not shown), and covered with a plate 101 which is bolted to adjacent terminals. In order to provide a passageway through the cores 75, 76, pins 103 on the body of the mould 95 extend inwardly through the cores and are contacted by removable casting bars 105 introduced through rectangular apertures in panel 64. Encapsulating compound is poured into casting cavity 106 of the mould to produce an encapsulated assembly (Fig. 19, not shown) having a passage through each transformer core to permit adjustment of the number of secondary turns. Polyester resin containing a mineral filler such as ground silica powder, and a hardening agent, is a suitable encapsulating compound.
Patent GB-1226035-A (GB)
IPC: B65D6/10
Filed: 1968-09-18
Abstract: 1,226,035. Liquefied gas storage containers. CONCH OCEAN Ltd. 18 Sept., 1968 [12 Oct., 1967], No. 44324/68. Heading F4P. A non-self supporting fluid-tight cold-resistant flexible membrane tank 6 right hand side of Fig. 1, is supported against internal loads by a surrounding solid thermal insulation 5 which is itself supported by a rigid shell 2, e.g. the inner hull of a tanker and the membrane tank 6 is anchored to the insulation by rigid anglesectioned members 19, Fig. 5, which extend along and are secured to the junction of adjacent side top and bottom walls of tank 6 and referred to as corners, and members 19 are also rigidly secured to the corners of the insulation 5. The membrane tank is formed of nickel-steel corrugated sheets 16 and corrugated dihedral corner-pieces 17 and trihedral corner-pieces 17<SP>1</SP>, Fig. 4, to which are welded the angled anchor members 19 along regularly spaced intervals along the lengths of the corners of the membrane tank. Members 19 are bolted to spaced hardwood blocks 21, 22, adhesively secured to insulation panels 8 constructed as described in Specification 951,923. The spaces between adjacent hardwood blocks is occupied by balsa wood blocks 23. A modified membrane tank 41, Fig. 10, has stepped top and side walls providing internal entrant corners a and external re-entrant corners b.
Patent GB-1228542-A (GB)
IPC: B65G39/16
Filed: 1969-04-16
Abstract: 1,228,542. Endless conveyers. CINCINNATI MILLING MACHINE CO. 16 April, 1969 [5 Aug., 1968], No. 19518/69. Heading B8A. [Also in Division F2] To improve the tracking of a conveyer endless band supported on two end rollers, means are provided to produce a bow in at least one of the rollers, extending away from the other roller, when the endless band is not under tension. As shown, an endless band 10 is supported on end rollers 11 and 12, the roller 12 and an adjacent roller 32 being caused to bow away from each other by roller units 33 when rollers 36 and 37 of these units are moved towards each other. When, by means of screws 48, tension is applied to the band 10, the roller 12 returns to its unbowed condition and improved tracking results. The roller 32 takes up a curve twice that originally imparted to it. A similar arrangement is provided for bowing the end roller 11 which may or may not be adjustably mounted for tensioning purposes. The rollers 11, 12 are preferably tapered at their ends and include end portions 28, 29; 30, 31 rotatable in supports 25, 27. Roller 11 is driven. The band 10 is also supported by idler rollers 14, 15..
Patent GB-1228955-A (GB)
IPC: A01K1/06
Filed: 1968-04-05
Abstract: 1,228,955. Animal stalls. J. J. OHIER. 5 April, 1968 [5 April, 1967], No. 16557/68. Heading A1M. [Also in Division E2] A horizontally pivoting barrier for an animal stall is overbalanced after an initial pivoting movement by movment of liquid across its pivotal axis, making further pivoting in the same direction automatic. The barrier is preferably a hollow U-shaped tube, having two limbs 19 and a curved central portion 11, and pivoting on a cross-bar 10. In the closed position, the portion 11 of the barrier abuts against a stop 2 on the lintel 16 of the stall, and the portion 19 is filled with liquid 7. When the portion 19 is lifted by the animal leaving the stall the liquid flows into the portion 11, causing the barrier to rotate until it is upside down. Another animal may then enter the stall by pushing against the portion 11 until the barrier is horizontal after which transfer of liquid again effects pivoting of the barrier. The crossbar 10 is hung from rocking levers 8 pivoting on the cross-bar 9 of the stall (bounded by posts 3 and 5) so that animals of different heights can operate the barrier. The limbs 19 are preferably cranked out of the plane of the U.
Patent GB-1229788-A (GB)
IPC: D04B11/24
Filed: 1967-09-01
Abstract: 1,229,788. Knitting-machines. WILLIAM COTTON Ltd. 26 Aug., 1968 [1 Sept., 1967], No. 39997/67. Heading D1C. A straight-bar knitting machine has a transfer point bar which transfers several successively knitted welts, e.g. rib welts, to a magazine point bar above the needle beds, that is replacable when full. Magazine units are provided on each division. Transfer of welt from needles to point bar. The point bar 38-Figs.1, 10- is pivotally mounted between arms 38, 45 movable via lever systems by means of cams 44, 51 on the main cam shaft 52 to raise the bar. Before the welt RW is raised the selvedge yarn is cut and trapped by a hook-end cutter 85 and trapper 87 of unit 54. The unit is first displaced inwards from the selvedge, then out again for the cutter to search for the yarn as it is retracted to draw it to the trapper and fixed blade 88. The machine needle bar 5 is retracted to permit these movements. The point bar engages the needles to remove the loops and arms 45 are swung upwards by rotating shaft 74 by means of an auxiliary motor. The upward movement is interrupted to allow disengagement of the draw hooks 53. The interruption is timed depending on the length of the welt, and so a lever arm 78- Fig. 14-having a cam profile 83 fixed thereto is rotated by a flexible member 77a attached to the take up shaft 77. The two levers 75, 76 are normally urged into engagement as shaft 74 rotates to maintain contacts C1-C2, but when arm 75 strikes the profile the contact is broken to interrupt the rise. The draw hooks are advanced to project between the needles by a rack and pinion and the knocking over bits 8 rise to remove the welt. Transfer of welt to magazine. The movement of the transfer means is controlled from an upper cam shaft 24 extending across all the machine divisions and driven from the main shaft via a clutch engaged for transfer only. The clutch comprises a hub 132a driven from the main cam shaft 52 and freely rotatable on shaft 135, and a pivoted arm 132b on a hub fixed to shaft 135. The arm is urged by a spring into engagement with a slot in the first hub when the contraining lever 150 is pivoted by means of lever arm 153 following cam 154.  Transfer of the welt is carried out by knocking over bits 16-Figs. 1, 6-mounted in a bar on arms 18 movable longitudinally along arms 25 by linkage 20-22 controlled by cam shaft 24. The arms 25 may be swung by follower arm 27 to move the bits transversely. Transfer is further assisted by a tray 29 also swung by cam shaft 24. The bits are swung above and behind the loops on the points, and then lowered to engage and push the loops onto the magazine 15. The tray is swung forwards to catch the end of the welt and prevent it fouling the transfer points when they are lowered. When sufficient welts have accumulated on the magazine it is replaced by an empty one.
Patent GB-1230272-A (GB)
IPC: B63B21/66
Filed: 1969-11-28
Abstract: 1,230,272. Rope fairings. FLEET MFG. Ltd. 28 Nov., 1969 [29 Nov., 1968], No. 58260/ 69. Heading D1T. Each of the fairings 20 has at least one end piece 26 of deformable resilient material so that when the cable 10 flexes abutting fairings are not displaced along the cable. The fairings may be interconnected by elastic link members 60. The leading edge of the nose 27 of the fairing may be so shaped as to conform closely to the curvature of a wind-up drum. The nose 27 may be U-shaped in cross-section and be secured to the trailing section by rivets 141.
Patent GB-1233639-A (GB)
IPC: F02D41/12
Filed: 1969-09-19
Abstract: 1,233,639. Fuel injection systems. ROBERT BOSCH G.m.b.H. Sept. 19, 1969 [Sept. 21, 1968], No. 46258/69. Heading G1N. [Also in Division H3] In an I. C. engine fuel injection control system, fuel supply to the engine is cut-off when the butterfly valve is in its idling position and the engine speed is a predetermined amount in excess of the idling speed, i.e. when the engine is being driven by the vehicle, fuel supply being restored when the engine speed decreases to a predetermined speed below the cut-off speed but above the idling speed. Opening pulses are supplied to the valves 4 by a monostable multi-vibrator 40 triggered on synchronism with the engine speed by switches 31, 32 in a bi-stable multi-vibrator 20. The pulses from the output transistor 42 of the monostable multi-vibrator 40 are applied to block a transistor 60 which in turn renders a transistor 67 conductive, the transistor 67 being connected to respective AND transisters 16, 17 for respective groups of valves 4. The AND transistors are also connected to the outputs of the bi-stable multivibrator 20. In between opening pulses, i.e. when transistor 42 is blocked, capacitors 73, 76 arranged in a network 71, are charged, the charging voltage of 73, which is effected with short time constant, being dependent upon the temperature of the engine as sensed by N. T. C. resistor 93 but independent of engine speed, the charging voltage of 76, which is effected with long time constant, being dependent upon the engine speed. When transister 42 becomes conductive to produce an opening pulse, capacitors 73, 76 are discharged. When the butterfly valve is in its idling position, a switch S is closed, and if the engine speed is low, the charge stored in a capacitor 90 (which is charged between pulses when transistors 42, 70 are non-conductive) is discharged to apply a blocking pulse to transistor 60, the opening pulse then being applied to a group of valves 4 and transistor 70 being rendered conductive by feedback resistor 86. However, if the engine speed is so high that a negative potential appears at P at the commencement of the next following opening pulse as a result of the incomplete discharge of capacitor 73, transistor 70 can only become conductive during the discharge time of capacitor 90 and then transistor 60 is blocked only during this time which is insufficient to cause opening of the valves 4. Thus when the engine speed reaches a speed no, which is higher for laver temperatures, the fuel supply to the engine is blocked. The supply is unblocked when the engine speed is reduced to a speed n, which is also dependent upon the engine temperature. In an alternative arrangement, Fig.3 (not shown), two such networks 71 are connected in parallel to operate in the transistor 70, the one being temperature dependent as shown in Fig. 1, the other being independent of temperature. When the engine speed increases when the switch S is closed, the fuel supply is cut off by the network which is set to the lower cut-off speed, and the fuel supply is also restored by the network which is set to the lower restoring speed.
Patent GB-1233647-A (GB)
IPC: F24D19/10
Filed: 1969-06-13
Abstract: 1,233,647. Valves. H. A. TROESCH. 13 June, 1969 [15 June, 1968; 22 May, 1969], No. 30068/69. Heading F2V. [Also in Divisions F3-F4] A three-way mixing valve 19 in a central heating system comprises a diaphragm 20 the position of which relative to a seat 18 of the boiler output pipe 3 or inlet of a by-pass pipe 15 is controlled by a regulating diaphragm 27 which is dependent on the pressure differential across a pump 7 in the system as determined via pipes 24, 26. In a modification, the outlets of pipes 3, 15, Fig. 2, into the mixing valve are regulated by diaphragms 59, 60 mounted on a common shaft 56 having one end adjacent the pump formed as a piston 65 and a spring 63 attached to an inner casing 54 of the valve and the shaft exerts returning force. In a further modification, Fig. 3, the piston 65 is replaced by a diaphragm which together with the pump subdivides the valve casing into suction and pressure chambers.