Patent SG-11201808949S-A (SG)
Title: Combinations and methods comprising a capsid assembly inhibitor
Inventor: HARTMAN GEORGE
IPC: A61P31/14
Filed: 2017-04-14
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 111111101111 0 DOI 01011111010111101110ER301011111011111110 MINE Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/181141 A3 19 October 2017 (19.10.2017) WIPO I PCT (51) International Patent Classification: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, A61K 31/40 (2006.01) A61K 31/7072 (2006.01) KM, ML, MR, NE, SN, TD, TG). A61K 31/445 (2006.01) A61P 31/12 (2006.01) A61K 31/522 (2006.01) A61P 31/14 (2006.01) Published: A61K 31/675 (2006.01) — with international search report (Art. 21(3)) (21) International Application Number: — before the expiration of the time limit for amending the PCT/US2017/027802 claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (22) International Filing Date: 14 April 2017 (14.04.2017) (88) Date of publication of the international search report: 11 January 2018 (11.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/323,251 15 April 2016 (15.04.2016) US 62/421,035 11 November 2016 (11.11.2016) US (71) Applicants: NOVIRA THERAPEUTICS, INC. [US/US]; 3805 Old Easton Rd, Doylestown, PA 18902 (US). JANSSEN SCIENCES IRELAND UC [IE/IE]; Eastgate Village, Eastgate, Little Island Co Cork (IE). Inventors: HARTMAN, George; 1529 Tennis Circle, Lansdale, PA 19446 (US). FLORES, Osvaldo; c/o Novira (72) Therapeutics, Inc., 3805 Old Easton Rd., Doylestown, PA = 18902 (US). KLUMPP, Klaus; c/o Novira Therapeutics, — Inc., 3805 Old Easton Rd., Doylestown, PA 18902 (US). = LAM, Man, Lu; c/o Novira Therapeutics, Inc., 3805 Old = Easton Rd., Doylestown, PA 18902 (US). BERKE, Jan, Martin; c/o Janssen Pharmaceutica NV, Turnhoutseweg = 30, 2340 Beerse (BE). Agent: TRINQUE, Brian, C. et al.; Lathrop & Gage, LLP, 28 State Street, Boston, MA 02109 (US). (74) = Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, = (81) = = CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, = = KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, = — MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, = PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = Designated States (unless otherwise indicated, for every — (84) M 1-1 71' kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 1-1 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 1-1 GC MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 1-1 IN 1-1 (54) Title: COMBINATIONS AND METHODS COMPRISING A CAPSID ASSEMBLY INHIBITOR 0 ei (57) : The present disclosure is directed to capsid assembly inhibitor compositions and methods for use in the treatment of 0 hepatitis B virus infection.