Patent SG-11201804225P-A (SG)
Title: Inhibitors of influenza virus replication, application methods and uses thereof
Inventor: ZHANG YINGJUN
IPC: C07D519/00
Filed: 2016-12-08
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau (43) International Publication Date ..... ..sr.1 15 June 2017(15.06.2017) WIPO I PCT ID Hit (10) 1111111111111111111 WO International Ell 2017/097234 Publication 11111111111111111111111111111RIIIIIIIIIIIIIII Al Number (51) International Patent Classification: Dongyangguang Hi-tech Park, Zhen An Road No. 368, CO7D 471/04 (2006.01) A61K 31/522 (2006.01) Shang Sha, Chang An Town, Dongguan, Guangdong CO7D 519/00 (2006.01) A61K 31/519 (2006.01) 523871 (CN). A61K 31/52 (2006.01) A61K 31/517 (2006.01) A61K 31/437 (2006.01) A61K 31/5377 (2006.01) (74) Agent: TSINGYIHUA INTELLECTUAL PROPERTY A61K 31/506 (2006.01) A61P 31/16 (2006.01) LLC; Room 301 Trade Building, Zhaolanyuan, Tsinghua University, Qinghuayuan,Haidian District, Beijing 100084 (21) International Application Number: (CN). PCT/CN2016/109079 (81) Designated States (unless otherwise indicated, for every (22) International Filing Date: kind of national protection available): AE, AG, AL, AM, 8 December 2016 (08.12.2016) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (26) Publication Language: English HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (30) Priority Data: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 201510908329.2 9 December 2015 (09.12.2015) CN NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (71) Applicant: SUNSHINE LAKE PHARMA CO., LTD. RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, [CN/CN]; Northern Industrial Area, Songshan Lake, Dong- TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, guan, Guangdong 523000 (CN). ZA, ZM, ZW. (72) Inventors . ZHANG, Yingjun; Dongyangguang Hi-tech (84) Designated States (unless otherwise indicated, for every kind of regional available): ARIPO (BW, GH, Park, Zhen An Road No. 368, Shang Sha, Chang An protection Town, Dongguan, Guangdong 523871 REN, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (CN). Qingy- Dongyangguang Hi-tech Park, Zhen An Road No. 368, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, un; TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Shang Sha, Chang An Town, Dongguan, Guangdong DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, 523871 (CN). TANG, Changhua; Dongyangguang Hi- LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, tech Park, Zhen An Road No. 368, Shang Sha, Chang An SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Town, Dongguan, Guangdong 523871 (CN). LIN, Xiao- hong; Dongyangguang HiPark, Zhen An Road No. GW, KM, ML, MR, NE, SN, TD, TG). -tech 368, Shang Sha, Chang An Town, Dongguan, Guangdong Published: 523871 (CN). YIN, Junjun; Dongyangguang Hi-tech with international search report (Art 21(3)) Park, Zhen An Road No. 368, Shang Sha, Chang An Town, Dongguan, Guangdong 523871 (CN). YI, Kai; 1-1 .4t i t M ei t--- cr\ O N 1-1 0 (54) Title: INHIBITORS OF INFLUENZA VIRUS REPLICATION, APPLICATION METHODS AND USES THEREOF ei : The invention provides a novel class of compounds as inhibitors of influenza virus replication, preparation methods 0 (57) thereof, pharmaceutical compositions containing these compounds, and uses of these compounds and pharmaceutical compositions thereof in the treatment of influenza.