Patent SG-11201906681P-A (SG)
Title: N1 -(4-(5-(cyclopropylmethyl)-1 -methyl-1 h-pyrazol-4-yl)pyridin-2-yl)cyclohexane-1,4-diamine derivatives and related compounds as ck1 and/or iraki inhibitors for treating cancer
Inventor: LI DANSU
IPC: A61K31/506
Filed: 2018-01-30
Abstract: International Patent Classification: CO7D 401/04 (2006.01) A61K 31/506 (2006.01) CO7D 403/04 (2006.01) A61K 31/4155 (2006.01) C07D 417/04 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 09 August 2018 (09.08.2018) WIPO I PCT omit °nolo milli offi onion° oimIE (10) International Publication Number WO 2018/142393 Al PCT/IL2018/050100 (22) International Filing Date: 30 January 2018 (30.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/453,192 01 February 2017 (01.02.2017) US (71) Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW [IL/IL]; Hi Tech Park, Edmond J. Safra Campus, Givat Ram, 9139002 Jerusalem (IL). (72) Inventors: LI, Dansu; 2690 Fawn Lane, Warrington, Pennsylvania 18976 (US). SNIR-ALKALAY, Irit; 63/3 Habosem St., 9076901 Mevasseret Zion (IL). VACCA, Joseph; 733 Indian Creek Road, Telford, Pennsylvania 18969 (US). BEN-NERIAH, Yinon; 5 Mevo Duvdevan St., POB 1691, 9071923 Mevasseret Zion (IL). VENKAT- AC-IALAM, Avanthika; Jerusalem (IL). (74) Agent: VOLMAN, Gail; Dr. Shlomo Cohen & Co., B. S. R Tower 3, 5 Kineret St., 5126237 Bnei Brak (IL). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) (54) Title: N1 -(4-(5-(CYCLOPROPYLMETHYL)-1 -METHYL-1 H-PYRAZOL-4-YL)PYRIDIN-2-YL)CYCLOHEXANE-1,4- DIAMINE DERIVATIVES AND RELATED COMPOUNDS AS CK1 AND/OR IRAKI INHIBITORS FOR TREATING CANCER W O 20 18/ 142393 Al R2 (57) : The present invention provides pyra- zole derivatives of Formula (I), and in par- ticular N1 -(4-(5-(cyclopropylmethyl)-1 -methy1-1H-pyrazol-4-y1) pyridin-2-yl)cyclohexane-1,4-diamine derivatives and related com- pounds as casein kinase 1 (CK1) and/or interleukin 1 receptor asso- ciated kinase 1 (IRAKI) inhibitors for treating cancer, inflammatory and immune related disorders. (I)