Patent SG-11201811316Y-A (SG)
Title: Phosphoramidates for the treatment of hepatitis b virus
Inventor: DE LA ROSA ABEL
IPC: A61K31/7068
Filed: 2017-06-23
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\"1 WO 2017/223421 Al 28 December 2017 (28.12.2017) WIP0 I PCT (51) International Patent Classification: A61K 31/7068 (2006.01) C07H 19/10 (2006.01) Published: — with international search report (Art. 21(3)) (21) International Application Number: — before the expiration of the time limit for amending the PCT/US2017/038963 claims and to be republished in the event of receipt of (22) International Filing Date: amendments (Rule 48.2(h)) 23 June 2017 (23.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/354,471 24 June 2016 (24.06.2016) US (71) Applicant: EMORY UNIVERSITY [US/US]; 1599 Clifton Road NE, 4th Floor, Atlanta, Georgia 30322 (US). (72) Inventors: DE LA ROSA, Abel; 6580 Ridgefield Drive, Alpharetta, Georgia 30005 (US). PAINTER, George; 1599 Clifton Road NE, 4th Floor, Atlanta, Georgia 30322 (US). BLUEMLING, Gregory R.; 3131 North Druid Hills Road, Apt 8101, Decatur, Georgia 30033 (US). Agent: JACKSON BECKFORD, Shirlene et al.; Meunier (74) _ Carlin & Curfman LLC, 999 Peachtree Street, NE, Suite — 1300, Atlanta, Georgia 30309 (US). = Designated States (unless otherwise indicated, for every (81) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, = — DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, _= HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, = — KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, = = = SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, = = TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = Designated States (unless otherwise indicated, for every (84) _ _ kind of regional protection available): ARIPO (BW, GH, = GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, = TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, — MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). = 1-1 11 ei - N ii el (54) Title: PHOSPHORAMIDATES FOR THE TREATMENT OF HEPATITIS B VIRUS ei ---- (57) : Disclosed are compounds and compositions to the treatment of infectious diseases and methods of treating such diseases. IN The compounds and compositions include derivatives of clevudine. The compounds and compositions include derivatives of clevudine C::::) in combination with another antiviral agent. The compounds and compositions include derivatives of clevudine in combination with a N phosphoramidate of lamivudine, adefovir, tenofovir, telbivudine, entecavir, or combinations thereof. C