baber/WOPTO huggingface dataset:
Patent EP-3982991-A2 (EP)
Title: Nrp-1 binding inhibitory peptides and uses thereof
Inventor: LEPELLETIER YVES
IPC: C07K7/02
Filed: 2020-06-10
Abstract: A number of anti-angiogenic strategies connected with the VEGF signalling pathway are used in current clinical treatment or trial phase, but they either cause adverse effects or are not specific. Various strategies were aimed at identifying peptides inhibiting the VEGF-A 165 /NRP-1 interaction. A well-known antiangiogenic peptide is the heptapeptide termed "A7R" having the amino acid sequence ATWLPPR, for which various derivatives have been synthesized, which include peptides having the general sequence Lys(hArg)-AA 2 -AA 3 -Arg. However, the ability of the known peptides to inhibit the VEGF-A 165 /NRP-1 interaction was too low for their use as candidate drugs for inhibiting angiogenesis in subjects in need thereof. The present inventors have now conceived a family of novel peptide-like compounds having a nanomolar affinity for NRP-1, which are thus endowed with a powerful capacity to inhibit the VEGF-A 165 /NRP-1 interaction. These novel peptide-like compounds may be relevantly used as antiangiogenic compounds, especially in subjects affected with cancer.
Patent EP-4061274-A2 (EP)
Inventor: FORST PETER
IPC: B25B23/14
Filed: 2020-11-19
Abstract: A head stabilization device includes a stabilization assembly and an applicator to control an amount of force that a stabilization feature applies to the head of the patient. The applicator includes a torque control feature that ensures a desired torque setting is not exceeding during use. The applicator can be detached from the remainder of the system such that the head stabilization device is usable without having a connected torque controlling feature or structures. The applicator in one version controls torque by adjusting a bending length of a pair of arms that extend within the applicator.
Patent EP-3922965-A2 (EP)
Title: Hand-held micro-raman based detection instrument and method of detection
Inventor: AUNER GREGORY WILLIAM
IPC: G01J3/28
Filed: 2014-08-07
Abstract: A Raman spectroscopy based system and method for examination and interrogation provides a method for rapid and cost effective screening of various protein-based compounds such as bacteria, virus, drugs, and tissue abnormalities. A hand-held spectroscope includes a laser and optical train for generating a Raman-shifting sample signal, signal processing and identification algorithms for signal conditioning and target detection with combinations of ultra-high resolution micro-filters and an imaging detector array to provide specific analysis of target spectral peaks within discrete spectral bands associated with a target pathogen.
Patent EP-4020975-A2 (EP)
Title: Time-resolving computational image sensor architecture for time-of-flight, high-dynamic-range, and high-speed imaging
Inventor: WANG YIBING MICHELLE
IPC: H04N5/3745
Filed: 2021-09-20
Abstract: A pixel for an image sensor includes a photon sensor, a memory, and an accumulator. The photon sensor element portion outputs a signal to an accumulator, which then may add value stored in memory together and may transfer the result to the memory of another pixel. The pixel may be analog or digital and may be used in a pixel array for compressed sensing imaging. During imaging, a pseudo-random mask may also be used. The data collected during imaging may be used in compressed sensing and may be sent to an offline storage to be processed.
Patent EP-4088919-A2 (EP)
Inventor: BAKOS STEFAN
IPC: B29D30/00
Filed: 2022-05-09
Abstract: A method comprises the steps of: i) moving the clamping unit (1) to the stacking point A (6); ii) overhead clamping of the first bead (3) stored on the stack by the clamping unit (1), if one or more separators (2) are on top, the clamping is performed by vertical entry of the jaws of the clamping unit through a radial holes (2.1) of the separators (2); iii) transfer of the clamping unit (1) with the clamped beads and any separators placed on the beads (3) to the transfer point B (8) and release of the beads to the mobile unit, if one or more separators are mounted on the transferred bead, the lowermost separator (2) is clamped; iv) moving the clamping unit (1) with the separator (2) or the separators to the stacking point A, and releasing the separators onto the tray. The present invention also relates to the equipment for this method.
Patent EP-4241700-A2 (EP)
Inventor: DIXON ERIC R
IPC: A61B17/12
Filed: 2018-04-18
Abstract: An implantable prosthetic device includes a coaption portion, paddles, and clasps. The paddles are moveable from a closed position to an open position. The clasps are also moveable from an open position to a closed position. The implantable prosthetic device can be used to repair a naitive valve, such as a native mitral valve.
Patent EP-4250628-A2 (EP)
Title: Subframe type notification and determination methods and device
Inventor: XUEJUAN GAO
IPC: H04L5/14
Filed: 2017-05-19
Abstract: Disclosed are a subframe type notification and determination methods and device. The invention enables a terminal to dynamically determine a subframe type, such that a subframe type can be flexibly changed to adapt to different service transmission requirements, thereby increasing system transmission efficiency. The subframe type determination method of the invention comprises: detecting, in a preset resource, indication information for determining a subframe type; and determining, according to a detection result, the subframe type.
Patent EP-4257170-A2 (EP)
Inventor: SHOULDICE REDMOND
IPC: A61M16/16
Filed: 2020-10-30
Abstract: Disclosed are devices, methods, and systems for providing a personalized humidification level. A humidifier device is configured to operate in conjunction with a respiratory therapy system configured to provide, via a user interface, an airflow to airways of a user for respiratory treatment, the respiratory therapy system comprising a humidifier unit configured to output moisture into the airflow. The humidifier device comprises a humidifier module configured to output moisture for changing humidity in an environment of the humidifier unit; memory storing machine readable instructions; and a control system with one or more processors, the one or more processors configured to execute the machine readable instructions to: receive from the respiratory therapy system information on operation of the humidifier unit of the respiratory therapy system; receive, from a first sensor, one or more environmental parameters regarding conditions of the environment of the humidifier unit; and adjust one or more operation parameters of the humidifier unit or the humidifier device, based, at least in part, on the information on operation of the humidifier unit and the one or more environmental parameters.
Patent EP-4272580-A2 (EP)
Inventor: HSIEH YI-HSIEN
IPC: A23L33/175
Filed: 2022-06-22
Abstract: Disclosed herein is a method for alleviating a kidney disease or fibrosis of an organ in a subject, which includes administering to the subject a composition containing a ferrous amino acid chelate which includes ferrous ions and an amino acid.
Patent EP-4275604-A2 (EP)
Title: Blood collection system including a baffle
Inventor: MA YIPING
IPC: A61B5/155
Filed: 2020-01-16
Abstract: A blood sample collection system, may include a housing, the housing including a blood collection port; and a baffle chamber; a needle formed through the housing and into the blood collection port; and a baffle formed within the baffle chamber to counteract a vacuum within a blood collection tube when pierced by the needle.
Patent EP-4295755-A2 (EP)
Inventor: BROWN RICHARD L
IPC: A61B5/00
Filed: 2015-08-05
Abstract: A nerve integrity monitoring device includes a control module and a physical layer module. The control module is configured to generate a payload request. The payload request (i) requests a data payload from a sensor in a wireless nerve integrity monitoring network, and (ii) indicates whether a stimulation probe device is to generate a stimulation pulse. The physical layer module is configured to (i) wirelessly transmit the payload request to the sensor and the stimulation probe device, or (ii) transmit the payload request to a console interface module. The physical layer module is also configured to, in response to the payload request, (i) receive the data payload from the sensor, and (ii) receive stimulation pulse information from the stimulation probe device. The data payload includes data corresponding to an evoked response of a patient. The evoked response is generated based on the stimulation pulse.
Patent EP-4300462-A2 (EP)
Inventor: PFAU LARS
IPC: G08G1/16
Filed: 2021-06-11
Abstract: The present invention provides a controller capable of handling special travel made by a straddle-type vehicle. The present invention also obtains a rider-assistance system including such a controller. The present invention further obtains a control method capable of handling special travel made by a straddle-type vehicle. 
     Left target information and right target information are acquired on the basis of output of at least one surrounding environment detector (11c, 11d). The left target information is information on a target (T1) located on a left side of a travel line (DL) of a straddle-type vehicle (100). The right target information is information on a target (T2) located on a right side of the travel line (DL). A travel state of the straddle-type vehicle (100) is analyzed on the basis of at least one of the left target information and the right target information, and rider-assistance operation corresponding to an analysis result thereof is executed.
Patent EP-0013303-A2 (EP)
Inventor: BERGER FRITZ
IPC: A63B71/14
Filed: 1979-11-02
Abstract: Bei einem Handschutz für Karatesportler aus einem einstückigen, weichelastischen Schutzpolster besteht dieses aus einem Polyurethan-Integralschaum-Formteil, wobei der rohrförmige Unterarmbereich auf der Arm-Innenseite über seine ganze Länge mit einem schmalen Schlitz versehen und der Handbereich nach einer geschlossenen Faust ballonförmig geformt ist, der im Bereich der Fingerspitzen um etwa 180° gegenüber dem Handrückenbereich zurückgebogen ist und als Fingerhalterung einen innenliegenden angeformten Steg aufweist, und der mit einer seitlichen, schwach angewinkelten und am vorderen Ende geschlossenen Daumenschutzhülle versehen ist.
Patent EP-0021135-A2 (EP)
Inventor: HEMPEL MATTHIAS DR
IPC: A61Q1/00
Filed: 1980-06-03
Abstract: Mit der Erfindung wird ein kosmetisches Erzeugnis in Form eines festen Körpers, vorzugsweise Stiftes, zur Verfügung gestellt; der von seiner Zusammensetzung her als Creme verwendet werden kann. Das Erzeugnis wird aus einem Gemisch von Fettstoffen, Emulgatoren und wasserlöslichen Bindemitteln hergestellt, dem soviel Wasser zugesetzt wird, daß eine Masse von formbarer Konsistenz entsteht. Hieraus werden durch Kaltverformung vorzugsweise stiftförmig ausgebildete Formstücke hergestellt, denen anschließend das Wasser soweit entzogen wird, daß eine feste Struktur entsteht.
Patent EP-0026438-A2 (EP)
Inventor: BITTNER HARRY
IPC: E21D11/40
Filed: 1980-09-24
Abstract: A propping aid (1) is guided with its carrying part (2) on a monorail conveyor (15) in such a way that the supporting part (3) projects freely into the rill (4). The propping aid (1) is rotatably mounted at its rear supporting point (5). To apply the propping sections, the propping aid is lowered at the front supporting point by a lifting appliance (12). Carrying part (2) and supporting part (3) are connected by an intermediate part (13) and are offset parallel to one another so that the propping sections can be moved into position height after the propping aid (1) is lifted and advanced. A means (8) for safeguarding the face breast is provided at the supporting part (3), which means (8) can be extended and uncoupled as soon as the height of the won minerals permits it. <IMAGE>
Patent EP-0035125-A2 (EP)
Inventor: HOHL ROLF DR
IPC: A23K20/195
Filed: 1981-02-05
Abstract: What are disclosed are a method for recovering solid matter from a salinomycin culture broth by spray drying a low-fat culture broth in the presence of a physiologically acceptable solid agent preventing agglomeration, and a solid product so prepared.
Patent EP-0037538-A2 (EP)
Inventor: SCHIWECK REINHARD
IPC: B02C17/16
Filed: 1981-03-28
Abstract: Device for grinding solid-containing liquid dispersions by means of fine grinding bodies having a closed upright vessel with a square plan and rounded-off inner corners, a shaft, which is over-mounted on the upper end of the vessel by two bearings and is driven in suspended fashion coaxially into the vessel, having grinding discs, the radius of the rounded-off corners (2a) of the vessel (2) or, with angled-off corners, the cathetus length of the corners (2b) being in a ratio of 1:5 to 1:20 to the side length of the vessel, the height (V) of the vessel (2) being in a ratio of 1:4 to 1:6 to its side length (U), the two bearings (7 and 8) being arranged far apart from one another and the seal (10) on the breakthrough of the shaft into the vessel being a rotating mechanical seal with a single sliding ring. <IMAGE>
Patent EP-0043937-A2 (EP)
Inventor: ROLF MEINHARD DR
IPC: C09B29/42
Filed: 1981-06-19
Abstract: 1. Anthraquinone-azo compounds which, in one of their tautomeric structures, correspond to the formula (I)  see diagramm : EP0043937,P20,F3  wherein A designates an alpha-anthraquinone radical which is free from sulphonic acid groups and is optionally further substituted, or a heterocyclic anthraquinone radical which is free from sulphonic acid groups and is optionally further substituted and which preferably consists of at most 5 fused ring, R1 designates hydrogen, alkyl, aryl or hydroxyl, R2 designates hydrogen, halogen, nitro, cyano, optionally substituted carbamoyl, optionally substituted sulphamoyl, alkylcarbonyl, alkoxycarbonyl, alkanesulphonyl, optionally substituted benzenesulphonyl or a hetero-aromatic radical and, it not being possible for R1 and R2 to simultaneously designate hydrogen, R3 designates a C1 -C6 -alkyl radical which is optionally substituted by hydroxyl, C1 -C4 -alkoxy, phenyl, carbamoyl or C1 -C4 -alkylcarbamoyl, an optionally substituted cycloalkyl radical, an optionally substituted aralkyl radical or an optionally substituted aryl radical.
Patent EP-0034028-A2 (EP)
Inventor: WILSON ALEXANDER JOHN
IPC: B60T8/42
Filed: 1981-01-30
Abstract: An hydraulically-operated anti-skid braking system includes a pump (3) rotatable with a wheel to be braked and of the type which, once a predetermined minimum wheel speed is attained, produces a constant output flow irrespective of any further increase in the wheel speed, and a fixed orifice (40) through which the output flow from the pump (3) is circulated to provide a back pressure which is utilised to control the application of a brake. Since the pump (3) is rotatable with a wheel to be braked by the brake, the wheel is automatically prevented for locking.
Patent EP-0036705-A2 (EP)
Inventor: ROBINSON JOSEPH GORDON
IPC: C08G14/04
Filed: 1981-02-13
Abstract: This invention relates to a novel varnish for use in preparing glasscloth laminates which are stable at high temperatures. 
     The varnish comprises a phenolated naphthalene formaldehyde resin having a molecular weight from 350 to 500 and a combined phenol content from 37 to 54%, a curing agent for the resin, and a lower secondary alcohol as the solvent, the varnish containing about 50% w/w of the resin. 
     The varnish can be used to form glasscloth laminates for the production of printed circuit boards, copper clad laminates and blading for turbines.
Patent EP-0055885-A2 (EP)
Inventor: DAVIES DOUGLAS MORGAN
IPC: A61K38/28
Filed: 1981-09-15
Abstract: Disclosed are compositions suitable for pharmaceutical administration which comprise human insulin and accompanying adjuvants in a sterile aqueous diluent.
Patent EP-0056895-A2 (EP)
Inventor: LLOYD RAYMOND ALLEN
IPC: G08C15/06
Filed: 1981-09-16
Abstract: An automatic test system controlled by a general purpose digital central processor (20) is disclosed. The central processor accepts test programs in a high level compiler language such as Atlas. The Atlas program is compacted into a simplified language which is utilized to communicate with test devices (24,26,30) via a standard IEEE 488 data bus. Each of the test devices includes a programmable interface digital processor (44) which performs any translation that may be necessary in order to permit specific test instruments coupled to the central processor via the interface processor to perform the tests specified by the high level test programs. A switching matrix (28) also communicates with the digital processor (20) to connect the appropriate test device to the unit under test.
Patent EP-0053429-A2 (EP)
Inventor: HANSEN HOWARD CLAIR
IPC: B62D5/09
Filed: 1981-10-05
Abstract: © A power steering system, particularly advantageous for use on electric powered vehicles, in which the hydraulic pump (14) operates only when steering commands are given. Torque applied to the steering shaft (20) by rotation of a steering wheel (not shown) is translated to axial stress on a thin walled tube (88), the direction and intensity of which depend on the direction and amount of steer angle change commanded. The axial stresses are detected by strain gauges (130, 132, 134, 136), and the motor which powers the hydraulic pump (14) is activated only when stress is detected. Manual steering inputs enter the pump (14) on one side, and the powered servo motor (12) inputs enter on the opposite side, thus permitting the vehicle to be steered by manual input alone if the powered input fails. The components of the system are arranged in coaxial alignment, providing a compact system with improved heat dissipation qualities.
Patent EP-0053002-A2 (EP)
Inventor: ALLEN CHRISTOPHER MACLAREN
IPC: C08K5/49
Filed: 1981-11-19
Abstract: The specification describes and claims substantially odourless compositions having a pot life after mixing acceptable for use in manufacture and repair of aircraft and which cure at room temperature to provide a mass of heat and aircraft fuel resistant elastomeric material. The compositions comprise components which are at least substantially free of thiol and comprise a fluorocarbon copolymer, organic solvent, metallic oxide, epoxy compound and as crosslinking agent a diamino silane according to the general formula (i) namely
     Examples disclose compositions formed from admixture of two components comprising Viton A, methyl ethyl ketone, magnesium oxide, Epikote 828 and N-beta(aminoethyl) gamma-aminopropyl-trimethoxysilane. The compositions are suitable for forming coatings, adhesive bonds and seals, to metal parts of titanium and aluminium alloys which have resistance to aviation fuels and high temperatures. A primer composition for promoting adhesion especially to titanium alloys is described and comprises organic material having isocyanate and hydrolysable silane groups available for reaction e.g. a mixture of polyfunctional isocyanate and a hydrolysable silane of the general formula (ii) namely
     A preferred example primer comprises liquid MDI and gamma-glycidoxy propyl-trimethoxy-silane.
Patent EP-0035462-A2 (EP)
Inventor: FITZPATRICK DONALD CHARLES
IPC: B26D5/38
Filed: 1981-01-30
Abstract: A paper cutting machine and method including a double rotary knife consisting of two cylinders geared together each containing a knife which mates with another to form a scissor action to cut a web including a sensor for detecting the speed of the web and including a motor for driving the two cylinders wherein the sheet size can be set to a desired size to provide an input to a microprocessor which is connected to the sheet speed sensor and to a position feedback from the drive motor and which generates a modulated signal for the motor so as to cause the knives to travel at the web speed at the instant of cutting and to modulate the cylinder speed to obtain larger or smaller sheets. Novel rotary drums and drive train system having low inertia are provided to allow the rapid acceleration necessary for the invention. Also, the knives are mounted in a novel manner.
Patent EP-0057444-A2 (EP)
Inventor: POGANY STEFANO A
IPC: A01N37/44
Filed: 1982-01-29
Abstract: Dichloroamino acid derivatives having the formula:whereinH<sup>1</sup> and R<sup>2</sup> are independently(a) lower alkyl;(b) lower cycloalkyl;(c) lower (cycloalkyl-alkyl);(d) phenyl or lower alkyl-substituted phenyl;(e) halosubstituted phenyl;(f) lower alkoxy-substituted phenyl;(g) phenyl (lower alkyl); orR<sup>1</sup> and R<sup>2</sup> joined together form lower alkylene; and Z is(a) lower alkylene;(b) -(CH<sub>2</sub>)<sub>n</sub>-phenylene-(CH<sub>2</sub>)<sub>m</sub>- wherein n and m independently are integers from 0 to 5; (c)(d)(e) -(CH<sub>2</sub>)<sub>n+1</sub>-O-(CH<sub>2</sub>)<sub>m</sub>-; wherein n is an integer from 0 to 3 and m an 0-20; (f)or(g)-or a pharmaceutically acceptable salt thereof are prepared from chlorination of corresponding amino acids, and are found to be potent germicidal and fungicidal agents.
Patent EP-0075819-A2 (EP)
Inventor: FROMM DIETER DR
IPC: C07D251/60
Filed: 1982-09-18
Abstract: Die Melaminqualität kann verbessert werden, wenn man Katalysatoren, die bei der Synthese von Melamin, bei der Harnstoff in einer Wirbelschicht des Katalysators umgesetzt wird, eingesetzt werden, dadurch reaktiviert, daß man die Katalysatoren in der Wirbelschicht mit wasserdampfhaltigen Gasen in Abwesenheit von Sauerstoff bei Temperaturen von 250 bis 450°C behandelt.
Patent EP-0079515-A2 (EP)
Inventor: SCHWENDEMANN VOLKER DR
IPC: C07C273/18
Filed: 1982-11-02
Abstract: N,N'-disubstituted allophanic acid esters are prepared by reacting aromatic chloroformic acid esters with N,N'-disubstituted ureas at 20 to 160 DEG C without the addition of acid-binding agents. The N,N'-disubstituted allophanic acid esters which can be prepared by the process of the invention are valuable starting materials for the preparation of crop protection agents, pesticides, colouring matters, synthetic resins and plastics, waterproofing agents for textiles, washing agents, bleaches and adhesives.
Patent EP-0079516-A2 (EP)
Inventor: ELLENDT GUNTHER DR
IPC: C07C241/00
Filed: 1982-11-02
Abstract: Ein neues Verfahren zur Herstellung von hochreinem 4,4'-Diisocyanatodiphenylmethan, bei welchem aus Phosgenierungsprodukten von Anilin/Formaldehyd-Kondensaten destillativ gewonnene Diisocyanatodiphenylmethan-Isomere zunächst unter Einhaltung bestimmter Destillationsbedingungen von 2,2'- und 2,4'-Isomeren befreit und anschließend weiter destillativ aufgearbeitet werden, indem aus dem, von 2,2' und 2,4'-Isomeren befreiten Diisocyanat in einer ersten Endstufe 50 bis 90 Gew.-% in Form von reinem 4,4'-Diisocyanatodiphenylmethan als Kopfprodukt isoliert werden und aus dem Sumpf der ersten Endstufe in einer zweiten Endstufe ein weiterer Anteil an reinem 4,4'-Diisocyanatodiphenylmethan als Kopfprodukt abgetrennt wird.
Patent EP-0082477-A2 (EP)
Inventor: NAZARENKO NICHOLAS
IPC: C09D5/24
Filed: 1982-12-15
Abstract: Screen-printable conductor composition comprising (a) a conductive phase containing silver and base metal powders dispersed in a solution of (b) a multipolymer prepared by copolymerization of vinyl acetate, vinyl chloride, and an ethylenically unsaturated dicarboxylic acid and a linear aromatic polyester resin dissolved in (c) volatile nonhydrocarbon solvent.