Patent SG-11201803794Y-A (SG)
Title: Method for preventing or treating nosocomial pneumonia
Inventor: JAFRI HASAN
IPC: C12P21/08
Filed: 2016-11-28
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau ires.. 00) (43) International Publication Date ..... ..sr ,„,„. 8 June 2017 (08.06.2017) W I P0 1 PCT (10) WO International 111111111111311111111111111111111111111111111111111111111111111111111111111111111111111111 2017/095744 Publication Al Number (51) International Patent Classification: (74) Agents: MARTIN, Cynthia, Lan et al.; Medlmmune, CO7H 21/04 (2006.01) A61K 39/104 (2006.01) LLC, One MedImmune Way, Gaithersburg, MD 20878 C12P 21/08 (2006.01) C07K 16/00 (2006.01) (US). A61K 39/00 (2006.01) (81) Designated States (unless otherwise indicated, for every (21) International Application Number: kind of national protection available): AE, AG, AL, AM, PCT/US2016/063865 AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (22) International Filing Date: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, 28 November 2016 (28.11.2016) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, (25) Filing Language: English KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (26) Publication Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (30) Priority Data: SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, 62/260,935 30 November 2015 (30.11.2015) US TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: MEDIMMUNE, LLC [US/US]; One Medlm- mune Way, Gaithersburg, MD 20878 (US). (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (72) Inventors: JAFRI, Hasan; MedImmune, LLC, One GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Medlmmune Way, Gaithersburg, MD 20878 (US). DIGI- TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, ANDOMENICO, Anthony; Medlmmune, LLC, One TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Medlmmune Way, Gaithersburg, MD 20878 (US). MC- DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, CARTHY, Michael; MedImmune, LLC, One MedImmune LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, MD 20878 YU, Xiang-Qing; Way, Gaithersburg, (US). SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Medlmmune, LLC, One Medlmmune Way, Gaithersburg, GW, KM, ML, MR, NE, SN, TD, TG). MD 20878 (US). STOVER, Charles, K.; MedImmune, Declarations under Rule 4.17: LLC, One Medlmmune Way, Gaithersburg, MD 20878 (US). BISHOP, Brian; MedImmune, LLC, One Medlm- — as to applicant's entitlement to apply for and be a granted mune Way, Gaithersburg, MD 20878 (US). patent (Rule 4.170) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) [Continued on next page] Title: METHOD FOR PREVENTING OR TREATING NOSOCOMIAL PNEUMONIA (54) FIG.1 Study Day 12 4 8 15 22 29 50 4 )9 )9 )9 4^ - 19 Predose N -= 143 Day -7 to Day -1 Da 1 Treatment Arm 2: single IV dose of 1500 mg or 3000 mg MEIN3902 H Z LEI (/) Z Z 0 9-) N = 286 D ----49 LEP 0 0 (.t co ,.l LE_ 7 1 2 4 8 15 22 29 50 1\" i 1 1\" 1 N = 143 .4t — — * Treatment Arm single IV dose of placebo ll• Legend ll• ], It\"-- MED13902/piacebo administration in ii 01 Post-dose follow-up C:: , IN Il (57) : A method for preventing or treating nosocomial diseases, e.g., diseases caused by Pseudomonas aeruginosa, is O provided. The method includes administering to a susceptible human a specified dose of a bispecific antibody that that specifically \" binds Pseudomonas aeruginosa Psl and PcrV. WO 2017/095744 Al MIDEDIMOMMIDIIMMEHMOMINEMOIMINVOIMIE • \"\"\"°\"\"`' — with sequence listing part of description (Rule 5.2(a)) — with international search report (Art. 21(3))