Patent SG-11201803817P-A (SG)
Title: Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof
Inventor: WANG CHANGYU
IPC: C07K16/28
Filed: 2016-11-17
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property - Organization International Bureau (43) International Publication Date .... ....r .....1 26 May 2017(26.05.2017) WIPO I PCT ID Hit (10) WO International 2017/087678 111111111111111111111111111111111111111111111111111111111111R111111111111111 Publication A3 Number (51) International Patent Classification: V.; Route 206 & Province Line Rd., Princeton, NJ 08543 C07K 16/28 (2006.01) A61K 39/00 (2006.01) (US). RAJPAL, Arvind; 700 Bay Road, Redwood City, (21) International Application Number: CA 94063 (US). PCT/US2016/062540 (74) Agents: REMILLARD, Jane, E. et al.; Nelson Mullins Riley & Scarborough LLP, One Post Office Square, Bo- (22) International Filing Date: 17 November 2016 (17.11.2016) stop, MA 02109-2127 (US). (25) Filing Language: English (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (26) Publication Language: English AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (30) Priority Data: DO, DZ, EC, EE, EG, ES, I, GB, GD, GE, GH, GM, GT, 62/257,599 19 November 2015 (19.11.2015) US HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 62/303,990 4 March 2016 (04.03.2016) US KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (71) Applicant: BRISTOL-MYERS SQUIBB COMPANY MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, [US/US]; Route 206 & Province Line Road, Princeton, NJ OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, 08543 (US). SC, SD, SE, SG, SK, SL, SM, ST, S , SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (72) Inventors: WANG, Changyu; 32264 Ashley Way, Union ZW. City, CA 94587 (US). LONBERG, Nils; 700 Bay Road, Redwood City, CA 94063 (US). KORMAN, Alan, J.; 700 (84) Designated States (unless otherwise indicated, for every Bay Road, Redwood City, CA 94063 (US). SELBY, kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Mark, J.; 700 Bay Road, Redwood City, CA 94063 (US). TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, SRINIVASAN, Mohan; 10358 Glenview Avenue, Cuper- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, tiro, CA 95014 HENNING, Karla, A.; 7000 Bay (US). DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Road, Redwood City, CA 94063 (US). HAN, Michelle, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Minhua; 700 Bay Road, Redwood City, CA 94063 (US). SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Route 206 Province Line Rd., Prin- CHEN, Guodong; & GW, KM, ML, MR, NE, SN, TD, TG). ceton, NJ 08543 (US). HUANG, Richard; Route 206 & Province Line Rd., Princeton, NJ 08543 (US). Published: CHAKRABORTY, Indrani; 700 Bay Road, Redwood with international search report (Art 21(3)) City, CA 94063 HUANG, Haichun; 700 Bay Road, (US). — before the the time limit the Redwood City, CA 94063 (US). WONG, Susan, Chi- expiration of for amending en-Szu; 700 Bay Road, Redwood City, CA 94063 (US). claims and to be republished in the event of receipt of LI, Huiming; 100 Beaver Street, Waltham, MA 02453 amendments (Rule 48.2(h)) (US). BARNHART, Bryan, C.; 700 Bay Road, Redwood _ with sequence listing part of description (Rule 5.2(a)) City, CA 94063 (US). YAMNIUK, Aaron, P.; Route 206 (88) Date of of the international search report: & Province Line Road, Princeton, NJ 08543 (US). LEI, publication 3 August 2017 Ming; Route 206 & Province Line Rd., Princeton, NJ 08543 SCHWEIZER, Liang; Beijing West Rd, 758 (US). Long #15-1802, Shanphai PR (CN). HATCHER, Sandra, M .4t Ge IN It\"-- GO 0 ir.., (54) Title: ANTIBODIES AGAINST GLUCOCORTICOID-INDUCED TUMOR NECROSIS FACTOR RECEPTOR (GITR) AND Il USES THEREOF 0 N (57) : Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF recept - ega ) or (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.