baber/WOPTO huggingface dataset:
Patent DE-69416601-T2 (DE)
Inventor: KOREN EUGEN
IPC: C07K16/06
Filed: 1994-10-12
Granted: 1999-07-22
Abstract: Antibodies directed against idiotypes on naturally occurring human anti-animal antibodies are disclosed for use in inhibiting xenograft rejection in human patients. An effective quantity of these anti-idiotypic antibodies is injected into the actual or potential xenograft recipient in order to bind to the idiotypes expressed on anti-animal antibodies as well as subpopulations of B lymphocytes, to inhibit hyperacute rejection of transplanted animal tissues or organs by the human patient. Alternatively, anti-idiotypic antibodies are used in the form of immunoaffinity columns to deplete anti-animal antibodies from the recipient's serum. Methods of making mouse monoclonal, mouse recombinant, and human recombinant anti-idiotypic antibodies are described, as well as immunoaffinity columns containing immobilized anti-idiotypic antibodies. A method and means for assessing the expected character and severity of a patient's rejection response to transplanted animal tissues is described, as well as methods of identification, isolation and suppression of lymphocytes bearing anti-animal idiotypes.
Patent DE-69422999-T2 (DE)
Inventor: OUELLETTE ROBERT
IPC: A61F5/44
Filed: 1994-11-14
Granted: 2000-08-17
Abstract: A fluid pervious topsheet suitable for use on an absorbent article is disclosed. The topsheet includes an apertured, three-dimensional, macroscopically expanded, fluid pervious web having a textured wearer-contacting surface. The composite web permits liquids to penetrate while providing an improved, less plastic-like feel and visual aesthetics. The process of the present invention, in one embodiment, comprises extruding a polymeric film onto a forming structure, applying a pneumatic pressure to the film to cause the film to be urged into substantial conformance with the forming structure, and depositing a particulate material on said film while the film is in a semi-molten state. In another embodiment, the process of the present invention comprises extruding a polymeric film onto a forming structure, depositing a particulate material on the film while the film is in a semi-molten state to form a composite web, and applying a pneumatic pressure to the film to cause the film to be urged into substantial conformance with the forming structure.
Patent DE-69430863-T2 (DE)
Inventor: LOOK F
IPC: B41J2/325
Filed: 1994-02-02
Granted: 2002-11-21
Abstract: A portable system and method for printing variable information indicia on a reflective sign comprises providing a first polymeric sign component having a surface suitable for receiving a printed image. A definition of an image to be printed on the first sign component is provided to a portable computer. Indicia in the form of images is then rapidly transferred to the surface of the first sign component. <IMAGE>
Patent DE-69505095-T2 (DE)
Inventor: CANTORO AMALIO
IPC: C08B37/08
Filed: 1995-12-04
Granted: 1999-04-15
Abstract: Sodium hyaluronate viscous aqueous solutions of molecular weight from 1,200,000 to 2,200,000 Daltons at concentrations from 0.10% to 0.40% by weight are proposed for use as masking fluid in therapeutic photokeratectomy by means of excimer laser (PTK), which realizes the ablation of superficial layers of corneal tissue for the elimination of uneveness and macula derived from different traumatic or pathological conditions. Preferably, the proposed solutions also contain one or more cationic species selected from the group consisting of sodium, potassium, calcium and magnesium ion and one or more anionic species selected from the group consisting of chloride, phosphate and citrate ion and, preferably, glucose. The solutions according to the invention wet the cornea and protect its areas which remain distressed after surgery, enabling the obtainment of uniform and smooth ablated surfaces. Further, they enable the execution of intraoperative corneal topographic tests. <IMAGE>
Patent DE-69507600-T2 (DE)
Inventor: VARILA ELIAS
IPC: C11B1/04
Filed: 1995-02-28
Granted: 1999-06-24
Abstract: PCT No. PCT/FI95/00107 Sec. 371 Date Nov. 29, 1996 Sec. 102(e) Date Nov. 29, 1996 PCT Filed Feb. 28, 1995 PCT Pub. No. WO95/23837 PCT Pub. Date Sep. 8, 1995The invention relates to a method for improving the separation of water in a tall oil preparation process which comprises: a neutralization stage in which a mixture of soap and water is neutralized with carbon dioxide, a water separation stage in which the aqueous phase containing bicarbonate is separated from the soap, and a cooking stage in which the soap obtained from the preceding stage is cooked with sulfuric acid to form tall oil, the improvement comprising the procedure that, after the neutralization with carbon dioxide but before the water separation stage, a second neutralization with sulfuric acid is carried out. The invention also relates to a process comprising the stages presented above for the preparation of tall oil.
Patent DE-69513057-T2 (DE)
Inventor: GALEY JEAN-BAPTISTE
IPC: A61K8/00
Filed: 1995-01-20
Granted: 2000-07-20
Abstract: Mono- and di-esters of cinnamic acid (or one of its derivs.) and vitamin C, of formula (I), are new.  R1, R2, R3 = H, OH, alkoxy, fluoroalkoxy or alkylcarbonyloxy; R4 = H or -COR5; R5 = 1-20C alkyl or a gp. of formula (i).
Patent DE-69517331-T2 (DE)
Inventor: CATTERALL A
IPC: G01N33/566
Filed: 1995-11-09
Granted: 2001-01-04
Abstract: Methods and compositions related to the identification of compounds that block neurotransmitter release are disclosed. Using the methods of the present invention, candidate compounds may be screened for the ability to bind to presynaptic calcium channels such that the docking of presynaptic vesicles to presynaptic calcium channels will be inhibited. The present invention also discloses peptides useful in the screening methods.
Patent DE-69521925-T2 (DE)
Inventor: ARTER THOMAS C
IPC: C12Q1/26
Filed: 1995-03-24
Granted: 2002-03-28
Abstract: A multilayer analytical element comprising a support coated in the following order, top down to the support:     a) a spreading layer, b) a dye layer having a pH greater than 6.5 and comprising tyrosinase and a water-insoluble hydrazone coupling agent, c) a barrier layer that prevents passage of molecules having a molecular weight in excess of 5,000, and d) a reagent layer comprising salicylate hydroxylase and nictotinamide adenine dinucleotide (NADH), characterized in that the spreading layer comprises a compound selected from the group consisting of valproic acid, 8-anilino-1-naphthalenesulfonic acid (ANS) and the magnesium salt of 8-anilino-1-naphthalenesulfonic acid.
Patent DE-69523941-T2 (DE)
Inventor: BROEDERS WILHELMUS
IPC: B21D22/10
Filed: 1995-08-18
Granted: 2002-04-11
Abstract: A sweeping member (5), together with a plate (2) which is to be worked and lies on a layer (4) of resilient material of a table leaf (3), is pressed over a certain distance, the depth of impression, into the resilient layer (4). Subsequently the sweeping member (5) is slid substantially parallel to the supporting leaf (3) over the plate (2) in the direction of the arrow P1, the resilient layer (4) being continuously impressed, thereby causing the plate material (2) to deform at the site of the zone of impression. By moving the sweeping member (5) continuously over the plate (2), that portion of the plate (2) which has already been swept will begin to display a curvature having a certain radius R. By varying the depth of impression, the plate material (2) can be provided locally with different radii of curvature.
Patent DE-69524457-T2 (DE)
Inventor: BENOIT GORDON LEON
IPC: B32B7/02
Filed: 1995-06-28
Granted: 2002-08-01
Abstract: A laminated multi-layer film substrate comprises layers (a) and (b) each comprising at least 50 wt. % HDPE with density of at least 0.94 and oriented in 1 direction at least 3 times more than in the direction normal to the first and laminated so that the directions of major orientation are aligned. - Pref., both (a) and (b) comprise propylene polymer skin(s), pref. on both the inner and outer sides, and pref. comprising 10-20 wt. % LDPE. (b) is thermally laminated to (a). A laminating adhesive (c), pref. LDPE and/or LLDPE is used between (a) and (b), pref. with a primer between (a)/(b) and (c), the latter esp. being of ABA construction with a core layer (B) of LLDPE and layers (A) of LDPE. The substrate pref. further comprises a security device (d) between (a) and (b), esp. between the primer coatings on the inner sides of (a) and (b).
Patent DE-69609902-T2 (DE)
Inventor: UEMURA KAMON
IPC: G11B7/135
Filed: 1996-06-12
Granted: 2001-03-22
Abstract: An optical pickup includes a light source (21) for radiating a light beam, a diffraction element (22) for separating a light beam radiated from the light source into at least three beams, namely a main beam and two side beams, an objective lens (25) for converging the light beams separated by the diffraction element onto a signal recording surface of an optical recording medium (11), a light receiving unit (24) having a four-segment first light receiving portion (71) for receiving the main beam reflected by the recording surface of the optical recording medium and second and third light receiving portions (72, 73) arranged on respective sides of the first light receiving portion (71) for receiving the side beams reflected by the recording surface of the optical recording medium, and a calculation unit (26) for generating one tracking signal based on respective outputs of the first light receiving portion and for generating another tracking signal based on outputs of the second and third light receiving portions. In preferred emodiments of the apparatus, a disc discrimination unit sends a detection output of the optical disc both to the changeover switch selecting the desired tracking error signal and to an aperture ratio variable control unit.
Patent DE-69614808-T2 (DE)
Inventor: CARMES FRANCIS
IPC: B61L5/02
Filed: 1996-11-18
Granted: 2002-04-04
Abstract: The locking system (DV) for a point blade (16) comprises a runner (1) and a locking plate (2) adjoining the runner. A control bar (3) and a parallel locking bar (4) are next to each other. The external casing formed by the control and locking bars and the internal casing of the runner have complementary shapes so as to allow the bars to slide in the runner. First and second movable pegs (5,6) are freely held in first (7) and second (8) notches on the same side of the control and locking bars. The pegs can be driven longitudinally by the notches. The pegs are perpendicular to the longitudinal axes of the control and the operating bars.
Patent DE-69619591-T2 (DE)
Inventor: MONDIE GEORGE R
IPC: G01B11/04
Filed: 1996-06-06
Granted: 2002-10-24
Abstract: Apparatus and method for detection of leading and trailing edges of objects moving along a defined path. A light radiation source directs a light beam toward a beamspot on the path. Light reflected from the beamspot is received by two light sensors. An edge of an object moving along the defined path substantially blocks the light from being received by one light sensor. Circuitry is provided for distinguishing the difference in reflected light received at each light sensor and determining whether the leading edge or trailing edge of the object is blocking the reflected light. Length of detections (leading and trailing edges) and time interval between the detections of the leading and trailing edge are processed to provide information about the object such as height of the leading and trailing edges of the object and length of the object. Further processing or leading and trailing edge detections can detect overlapped objects having relatively uniform surfaces. <IMAGE>
Patent DE-69622098-T2 (DE)
Inventor: LEBLANC JACOBUS JOHANNES JOSEP
IPC: F15B11/20
Filed: 1996-08-05
Granted: 2003-02-27
Abstract: Hydraulic operating device for a plough which can be turned and whose width can be adjusted, comprising a width-adjustment cylinder for adjusting the operating width of the plough, a turning cylinder for turning the plough between a first and a second turned position, and a hydraulic turning circuit for turning the plough. The device furthermore comprises a hydraulic sequencing circuit, which is designed such that, when pressurized hydraulic fluid is fed to the pressure port thereof, the plough moves to its narrowest position, so that, when a narrow position of the plough which is suitable for turning the plough is reached, the fluid flows to the pressure port of the turning circuit and, from there, to the turning cylinder, so that the plough moves from its one turned position to its other turned position, and so that, when the position of the turning cylinder which is associated with the desired turned position of the plough is reached, the fluid flows to the other connection port of the width-adjustment cylinder, so that the plough moves to its widest position. <IMAGE>
Patent DE-69633236-T2 (DE)
Inventor: MARTUZA L
IPC: C07K14/035
Filed: 1996-06-06
Granted: 2005-09-15
Abstract: A method for killing tumor cells in vivo entails providing replication competent herpes simplex virus vectors to tumor cells. A replication competent herpes simplex virus vector, with an essential herpes simplex virus gene which is driven by a tumor-specific or cell-specific promoter that specifically destroys tumor cells and is not neurovirulent. Also, a method for producing an animal model, by ablating a specific cell type in vivo, entails providing replication competent herpes simplex virus vectors to the animal. Such a vector, with an essential herpes simplex virus gene driven by a cell- or tissue-specific promoter, specifically destroys the target cell type. This method of viral-mediated gene therapy employs cell-specific viral replication, where viral replication and associated cytotoxicity are limited to a specific cell-type by the regulated expression of an essential immediate-early (IE) viral gene product.
Patent DE-69637136-T2 (DE)
Inventor: BUETTNER JOSEPH A
IPC: G01N33/543
Filed: 1996-04-29
Granted: 2008-02-21
Abstract: Ligands that interact with a target can be more easily identified if false positive interactions (either specific or non-specific) from the detecting system are differentiated from the target-specific interaction. An improved method of identifying peptides which bind with a target protein is presented. The steps are: binding a random library of peptides to a support material, allowing detection reagents to contact the peptides and the support material then identifying these interactions, then allowing the target protein to selectively bind to the peptides, allowing detection reagents to contact the bound target protein, and characterizing the peptide bound to the identified support material. Interaction of a ligand or the support material with the detection reagents will cause a distinct color change which distinguishes those ligands which selectively bind to target protein. The characterized peptide can then be used in affinity purification of the target protein. In one embodiment, automation of the assay is demonstrated by flowing all immunoreagents through the beads in a column format ensuring highly efficient washing. In the preferred embodiment, a resin for peptide synthesis which is hydrophilic, contains spacers and may exhibit less nonspecific background than other resins permits synthesis and direct evaluation of combinatorial peptide libraries for binding to target proteins is utilized. Examples for the use of this new resin and methodology for identifying peptide-ligands for purification of proteins are presented.
Patent DE-69701666-T2 (DE)
Inventor: BOLELLI EMILIO
IPC: A61J3/07
Filed: 1997-10-08
Granted: 2000-11-23
Abstract: The dispensing device comprises a powder feeding container (1), an intermittently rotating body (7) provided with a circular channel (6) which receives the powder from the container (1) and is provided in its base with groups (X) of holes (9, 9A) alternately alignable with holes (12, 12A) present in an underlying intermittently rotating forming cylinder, a stationary closure member (10) lying below the rotating body (7) and comprising a series of holes (10B), a movable multiple pusher means (15, 16, 17, 18, 18A) which, when a group (X) of holes of the rotating body (7) become aligned with the holes (10B) of the closure member (10) and with a corresponding number of holes (12, 12A) of the forming cylinder (11), traverses the circular channel (6) and said aligned holes to feed into and compress within the holes (12, 12A) of the forming cylinder (11) given quantities of powder, which said forming cylinder conveys, compressed, into a position coinciding with a capsule base (2) which is aligned with a hole (12) of said forming cylinder (11) and where the multiple pusher means transfers a compacted measure of powder into the capsule base (2), the multiple pusher means comprising three presser members (15, 16, 17) for transferring and compressing the powder, and an expulsion member (18) for transferring the compressed powder mass into the capsule base (2). <IMAGE>
Patent DE-69717080-T2 (DE)
Inventor: SONERUD AKE
IPC: E02F3/36
Filed: 1997-02-17
Granted: 2003-07-17
Abstract: A coupling arrangement for coupling a working implement to a working machine and being of the kind in which the two coupling parts are mutually connected both mechanically and hydraulically with no manual handling of the coupling arrangement. The machine-mounted coupling part has a drive means for moving associated hydraulic coupling connection means into coupling engagement with hydraulic coupling means on the implement-mounted coupling part, when coupling the machine and implement. The hydraulic coupling connection on the implement-mounted coupling part is movable in the direction of maneuvering movement of the hydraulic coupling, and is moved by the drive means via the hydraulic coupling connection on the machine-mounted coupling part until coming into abutment with an abutment means on the machine-mounted coupling part. The arrangement includes springs that function to exert a pressure that is opposed to this movement. The arrangement ensures that the clearance required for this mechanical coupling will not prevent effective and positive connection of the hydraulic couplings.
Patent DE-69727680-T2 (DE)
Inventor: SCOTT L
IPC: C07H15/18
Filed: 1997-05-20
Granted: 2004-12-02
Abstract: A process of preparing mannosylated alcohols or phenols in high chemical yield and purity using tetra-+E,uns O+EE -pivaloylmannosylfluoride and a Lewis acid catalyst.
Patent DE-69729995-T2 (DE)
Inventor: LEIKAUF BERNHARD
IPC: C04B24/32
Filed: 1997-04-08
Granted: 2005-07-21
Abstract: PCT No. PCT/EP97/01730 Sec. 371 Date May 22, 1998 Sec. 102(e) Date May 22, 1998 PCT Filed Apr. 8, 1997 PCT Pub. No. WO97/39037 PCT Pub. Date Oct. 23, 1997The invention relates to a random styrene-maleic anhydride (SMA) copolymer in free acid or salt form wherein the copolymer has the following types and numbers of monomer units in which M is selected from hydrogen, a cation and a residue of a hydrophobic polyalkylene glycol or polysiloxane, R is the residue of methylpoly(ethylene)glycol of molecular weight (weight-average) 900-2000, x=0.35-0.75 and y=0.25-0.65. These copolymers are particularly useful as superplasticizers in cementitious compositions such as concretes and mortars.
Patent DE-69802808-T2 (DE)
Inventor: GASSER GERARD
IPC: G03C5/00
Filed: 1998-06-12
Granted: 2002-08-01
Abstract: A method for separating metal ions absorbed on a resin includes: suspending or percolating a cationic exchange resin charged with a polar solvent containing an eluting agent or a mixture of eluting agents containing at least an organic or mineral ligand complexing the metal ions to be separated; circulating a direct electric current, whether constant or not, in the charged eluting solution forming an electrolyte so as to recuperate at least a metal by deposition; and finally optionally repeating the last step by setting up one or several cathode(s) made of another metal and by re-adjusting the cathode potential and the anode/cathode potential difference to new values, depending on the new type of metal to be recuperated. An installation for treating/recycling photographic bath waste includes an exchanger connected to a tank for waste bath to be treated, to a treated waste bath tank, to a regenerating solution tank and to an electrolysis vessel.
Patent DE-69806051-T2 (DE)
Inventor: NICULESCU FLORIN
IPC: B62M11/06
Filed: 1998-12-09
Granted: 2003-02-06
Abstract: The crankset with no dead center position includes a single crankshaft (108), fitted with a left crank (11) and a support hub (119) provided with a lever (20). This hub is mounted by a roller bearing (28) in a stationary eccentric member (26) which supports a rotatable chain wheel carrier (15). The hub also supports the right crank (13) via pre-stressed bearings (62, 63). The lever (20) and said crank (13) drive the chain wheel carrier by means of two articulated connecting rods (21 and 23). An indexing ring (30) is provided on the fixed crankset tube (2) to prevent the eccentric member (26) from rotating. These means can include a force sensor allowing a measuring device to calculate the energy and the power transmitted through the crankset. Such a crankset can be used for driving bicycles and other muscle-powered vehicles or machines.
Patent DE-69814381-T2 (DE)
Inventor: MATSUI HIROSHI
IPC: A61K31/4025
Filed: 1998-02-02
Granted: 2003-12-04
Abstract: A carbapenem compound of the formula (I) <CHEM> wherein each symbol is as defined in the specification, and a pharmaceutically acceptable salt thereof. The carbapenem compound (I) and a pharmaceutically acceptable salt thereof of the present invention show superior absorption from digestive tract by oral administration, and sufficient antibacterial activity against a wide variety of bacterial species. Thus, they are extremely useful as agents for the prophylaxis and treatment of infectious diseases, particularly bacterial infectious diseases. Said agents for the prophylaxis and treatment of infectious diseases can be used as agents for the prophylaxis and treatment of the diseases caused by bacteria (e.g., suppurative diseases, respiratory infectious diseases, inflammatory diseases of biliary tract, urinary tract infection and the like) in warm-blooded animals inclusive of human (e.g., dog, cat, cow, horse, rat, mouse and the like).
Patent DE-69819369-T2 (DE)
Inventor: HALLUNDBAEK JOERGEN
IPC: E21B17/046
Filed: 1998-04-14
Granted: 2004-06-24
Abstract: In an assembly for cylindrical drill pipes made for the transport of different kinds of fluids, a combined flange assembly can combine the functions and can be assembled under low time consumption and at low cost. Drill rods are connected by axially directed bolts inserted in the outer wall of a first drill rod (1) and extending axially past the end of the first drill rod (1) into internally threaded blind holes (21, 22) in the next drill rod to be connected to the first drill rod. Each terminal surface of a drill rod is made with arrangements (13-17, 23-27) for at least one coupling plug (31, 33) for the transport of different kinds of fluids in the drill string.
Patent DE-69820933-T2 (DE)
Inventor: SAU ARJUN CHANDRA
IPC: C09D103/00
Filed: 1998-07-28
Granted: 2004-11-04
Abstract: Water-borne paints containing reduced molecular weight polysaccharide derivatives that are resistant to enzyme hydrolysis. The water-borne paints are biostable, retaining at least about 80% of their initial viscosity 24 hours after they are inoculated with polysaccharide hydrolysis enzyme. A process for making the biostable water-borne paints has the steps: a) treating precursor polysaccharide derivative with polysaccharide hydrolysis enzyme in aqueous medium for a time sufficient to obtain reduced molecular weight polysaccharide derivative; and b) mixing the reduced molecular weight polysaccharide derivative with an effective amount of at least one other water-borne paint ingredient to obtain a water-borne paint.