baber/WOPTO huggingface dataset:
Patent DO-P2020000019-A (DO)
Title: Amidas heterocíclicas útiles como moduladores de proteínas
Inventor: JOSEPH J ROMANO
IPC: C07F9/09
Filed: 2020-01-30
Abstract: Se describen compuestos que tienen la fórmula: (I-N) en donde q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, y R17, son como se definen en la presente memoria, o un tautómero de los mismos, o una sal, en particular una sal farmacéuticamente aceptable de los mismos.
Patent EC-SP13013001-A (EC)
Title: Moléculas de unión biespecíficas que se unen a vegf y ang2.
Inventor: GSCHWIND ANDREAS
IPC: C07K16/26
Filed: 2013-10-28
Abstract: Se describen moléculas de unión biespecíficas que se unen tanto a VEGF como a Ang2, preferiblemente en forma de dominios variables individuales de inmunoglobulina tales como VHH y anticuerpos de dominio, composiciones farmacéuticas que las contienen y su uso en el tratamiento de enfermedades que están asociadas con los efectos mediados por VEGF y/o Ang2 sobre la angiogénesis. Además, también se describen ácidos nucleicos que codifican moléculas de unión biespecíficas, células hospedadoras y métodos para prepararlos.
Patent EC-SP14013316-A (EC)
Title: ANTICUERPOS CAPACES DE NEUTRALIZAR LAS PRINCIPALES EXOTOXINAS TcdA y TcdB de Clostridium difficile
Inventor: COX MATTHEW
IPC: C07K16/12
Filed: 2014-04-16
Abstract: La presente invención describe la derivación y selección de anticuerpos capaces de neutralizar las principales exotoxinas; TcdA y TcdB de Clostridium difficile. La invención también describe nuevas propiedades de neutralización y de unión de antígeno de Mabs individuales y mezclas de los mismos.
Patent EE-200000691-A (EE)
Inventor: BUTLIN ROGER JOHN
IPC: A61K31/5375
Filed: 1999-05-26
Abstract: The use of compounds of formula (I), and salts thereof; and pharmaceutically acceptable in vivo cleavable prodrugs of said compound of formula (I); and pharmaceutically acceptable salts of said compound or said prodrugs; in formula (I), Ring C is phenyl or a carbon linked heteroaryl ring substituted as defined within; R<SUP>1 </SUP>is an ortho substituent as defined within; n is 1 or 2; A-B is a linking group as defined within; R<SUP>2 </SUP>and R<SUP>3 </SUP>are as defined within; R<SUP>4 </SUP>is hydroxy, hydrogen, halo, amino or methyl; in the manufacture of a medicament for use in the elevation of PDH activity in warm-blooded animals such as humans is described. Pharmaceutical compositions, methods and processes for preparation of compounds of formula (I) are also described
Patent EG-25443-A (EG)
Title: Reduction process and plant
Inventor: MARTINIS ALESSANDRO
IPC: C21B13/02
Filed: 2008-07-29
Granted: 2012-01-08
Abstract: Reduction process and relative plant for the production of metallic iron by means of the direct reduction of iron ore, in which a reduction shaft is connected to a source of reducing gas obtained from the gasification of coal. The process advantageously comprises a step in which a portion or all of the synthesis gas entering the plant circuit is processed to separate the methane from the rest of the components of said synthesis gas. The advantageous management of the extracted methane enables the entire reduction process to be optimized, making the efficiency of the process independent of the methane content in the original synthesis gas and making it possible to control the carbon content of the product more accurately and more easily.
Patent GB-189705300-A (GB)
Title: Certain Improvements in Gear Wheels.
Inventor: RICHARDSON SAM THOMAS
Filed: 1897-02-27
Granted: 1898-01-08
Abstract: 5300. Richardson, S. T. Feb. 27. Toothed wheels.-The rims of the wheels each have holes and rounded metal studs arranged in rows, the studs on the one wheel engaging with the holes in the other.
Patent GB-189707940-A (GB)
Title: Improved Appliance to be Attached to Domestic Fire-ranges for Economising Fuel.
Inventor: WILKINSON ASHWORTH
Filed: 1897-03-27
Granted: 1898-02-12
Abstract: 7940. Wilkinson, A. March 27. Fuel-economizers. -A pair of similar castings D having lugs F, G, through which pass loosely the bars or rods E w h i c h constitute the fuel-economizer, are held in place on the front bars A of the grate by means of the pin or cottar H.
Patent GB-189707972-A (GB)
Title: Improvements in Instantaneous Steam Generators.
Inventor: DAGNALL ELLS
Filed: 1897-03-27
Granted: 1898-02-19
Abstract: 7972. Dagnall, E., and Southey, A. W. March 27. Instantaneous generators.-A series of close-ended tubes a, lying horizontally in the combustion space of the furnace, are connected to one another in series through the medium of the header d. Each tube a contains an inner tube b surrounded by a loosely-fitting anti-incrustating helical sleeve h. The course of the water for steam generation is by way of the inner tube b to its extreme open end, and back through the helical sleeve h and the passage e which communicates with the next inner tube. In a modification, an inner tube only is used for steam generation, its annular jacket being filled with water. By means of a three-way cock, water for steam generation may enter the tubular system at two points, thereby securing a mixture of superheated and saturated steam.
Patent GB-189709567-A (GB)
Title: Improvements in or relating to Luggage Carriers for Cycles.
Inventor: HENEAGE EVELINE MARY
Filed: 1897-04-14
Granted: 1898-02-26
Abstract: 9567. Heneage, E. M. April 14. Luggagecarriers. - Relates to devices for enabling articles such as sticks, umbrellas, golf clubs, guns, &c. to be readily attached and carried on bicycles and similar vehicles. A boot or socket A made of leather or other suitable material is secured to the lower part of the machine frame by a strap B, and forms a rest for the lower portion of the umbrella &c., the upper portion of which is connected to the cycle frame by means of a strap C carried by another strap D encircling the frame. Instead of a strap and buckle fastening, a metal clip or the like may be used, or the holders may be permanently attached to the cycle.
Patent GB-189711284-A (GB)
Title: Improvements in Stone Dressing Machinery.
Inventor: ANDERSON GEORGE
Filed: 1897-05-06
Granted: 1897-06-12
Abstract: 11,284. Anderson, G. May 6. Dressing stone.-The cross-slide is pivoted at 10, and is turned over at the end of the stroke by a horizontal lever 12. The -tools are secured in the slides by screws 17 in the cover-plate bolted to the slide. The belt shifter 23 is worked through a bell crank 24 by striking-plates 25 fixed to the table. Extensions 26 of the plates strike a removable roller 27 carried by an arm 28 on the shaft 29 on which the lever 12 is mounted.
Patent GB-189714165-A (GB)
Title: Improvements in Internal Combustion Engines using Hydrocarbon as Fuel.
Inventor: BARNES CHARLES
Filed: 1897-06-10
Granted: 1898-03-12
Abstract: 14,165. Barnes, C. June 10. Vapour burners.-A lamp for heating the igniting-tube and carburetter of an oil engine at starting comprises an oil vessel 1 with a blast pipe 2 in the middle surrounded by closely-packed wire gauze. A cover 4 with a handle 5 and holes for the escape of the flame is placed on after the oil in the gauze wick has been ignited. -
Patent GB-189718652-A (GB)
Title: Improvements in Mattresses.
Inventor: JUNGE CHARLES
Filed: 1897-08-11
Granted: 1897-09-11
Abstract: 18,652. Junge, C., [Steiner, O.]. Aug. 11. Mattresses.-A number of springs e are supported on a frame d, to which is pivoted a lever c<1>, c<2>, pivoted at b and connected at a<2> to an adjustable stay h, pivoted to the head - rest g, which is pivoted at g'. By adjusting the stay h, and the connection of the strap k the angle of the headrest can be varied. Figs. 7 and 8 show modifications ; in that shown in Fig. 7 the bar B<1> which forms the pivot can be placed in any of the grooves o, o<1>. The springs e can be connected by springs l.
Patent GB-189725278-A (GB)
Title: Improvements in and relating to Stands for Reels of Cotton or Thread.
Inventor: CLAYTON FRED
Filed: 1897-11-01
Granted: 1898-03-19
Abstract: 25,278. Clayton, F. Nov. 1. Pincushions.- A bobbin holder g is recessed on the top to receive pins, needles, thimbles, &c., and on the top of the support c is a cup b to receive a pincushion a.
Patent GB-189804738-A (GB)
Title: An Improved Method of and Apparatus for Obtaining a High Vacuum.
Inventor: MAXIM HIRAM STEVENS
Filed: 1898-02-25
Granted: 1899-05-25
Abstract: 4738. Maxim, H. S. Feb 25. Pumps for mercury have hard steel pistons m<14>, Fig. 14, which are weighted to keep the rods in tension, and are without stuffing-boxes, to prevent contamination of the mercury by grease. The weight may take the form of a cap m<x>, which slides over the pump barrel ; it has a stuffing-box m<4> that carries a piece of absorbent material m<6>, which dips into an oil cup at the end of the down-stroke. An air valve, Fig. 15, is opened by a lug m<3> on the connecting-rod m<10> during every down-stroke.
Patent GB-189805071-A (GB)
Title: Improvements in Boots, Shoes, and the like.
Inventor: NEWTON JOSEPH
Filed: 1898-03-01
Granted: 1898-12-10
Abstract: 5071. Newton, J. March 1. Heels; soles ; clogs ; slippers.-To the leather soles and heels are attached rubber treads, having boundary ribs c<3>, and set-back portions c<5>, c<6> at their middles. and sides. These treads may be attached by screws &c. and strips of wood m, or by dovetailing into the soles and heels proper, or by cement. The Provisional Specification states that strips of felt and wood may be similarly attached to slippers and clogs respectively.
Patent GB-189807165-A (GB)
Title: Improvements in or connected with Air Propellers.
Inventor: PICKARD FRED HATTERSLEY
Filed: 1898-03-24
Granted: 1899-01-14
Abstract: 7165. Pickard, F. H. March 24. Fans, screw. The boss A, pulley E or its equivalent, and bearings C are constructed so as to form a continuous surface that will not obstruct the passage of air. The blades G are set back at their peripheries, where they are attached to a ring K, have a delivery edge G<2> in the form of an arc, and increase in pitch from the inlet to the delivery edge.
Patent GB-189811514-A (GB)
Title: Improvements in or relating to Maps, Charts and the like.
Inventor: BOULT ALFRED JULIUS
Filed: 1898-05-20
Granted: 1899-03-18
Abstract: 11,514. Boult, A. J., [Mittelbach, R.]. May 20. Maps and charts.-Vertical projections of the roads &c. are indicated on maps and plans by showing the vertical sections between pairs of selected points. The colour employed for the vertical sections is such as to contrast with the general colour of the map. The elevations of the selected terminal points may be indicated by figures.
Patent GB-189811516-A (GB)
Title: An Improved Spray or Shower Bath.
Inventor: HUGHES WILLIAM CHARLES
Filed: 1898-05-20
Granted: 1898-08-20
Abstract: 11,516. Hughes, W. C. May 20. Baths.-Fig. 1 shows in section, and Fig. 2 in elevation, a spray or shower bath, which is preferably cylindrical and is supported on feet B to enable a heating-burner S<1> or S<2> to be placed beneath. The bather enters through an opening closed by a hinged or other door N, and stands on a wooden grating s supported by the perforated plate C forming the top of the water tank E. From this tank the water is raised by pumps L, L' to a higher one K, from which it passes to the shower rose r and to spraying-nozzles or rosettes. Those on the door N are supplied through a flexible pipe as shown in Fig. 2. Light is admitted through glazed panels, and air through perforations. If desired, the water may be pumped directly to the nozzles.
Patent GB-189811521-A (GB)
Title: Improvements in Stands for Bicycles.
Inventor: RIGBY GEORGE EDWIN
Filed: 1898-05-20
Granted: 1899-03-04
Abstract: 11,521. Rigby, G. E. May 20. Stands, folding, for bicycles. Fig. 1 shows a perspective view of the stand opened out. The support B is hinged to the bar A, and is fitted with legs D hinged to a sliding piece e and provided with links F. The bar A carries a block G for receiving the bottom bracket of the bicycle, a clip H for the front tube, and a strap K which can be fixed by a stud. A projection g on the block G enters between the rear forks. A wire frame L, with cross-piece M, is hinged to a plate l and serves to hold the front wheel. The legs D may be hinged directly to the support B, or can be fitted to the bar A. In a modification, T-shaped feet are hinged or rigidly fixed to one or both of the parts A, B.
Patent GB-189814588-A (GB)
Title: Improvements in Adjusting the Chains of Cycles and other Vehicles.
Inventor: BINKS CHARLES
Filed: 1898-07-02
Granted: 1899-07-01
Abstract: 14,588. Binks, C. July 2. Motor road vehicles.-The ends of the driving- wheel axle are cranked as shown at D in Fig. 1, the portions C being mounted in holes in the fork ends. The axle can be rotated so as to adjust the tension of the chain by means of a worm J mounted in the fork end and engaging a worm-wheel G secured on a squared portion of the axle end C. The worm J is rotated by means of a key adapted to engage its squared end K. Nuts H mounted on the axle ends C lock the axle in position as usual.
Patent GB-189814885-A (GB)
Title: An Improved Method of and Machine for Labelling and Wrapping Tins and other Vessels.
Inventor: FYFE SAMUEL
Filed: 1898-07-06
Granted: 1898-08-06
Abstract: 14,885. Fyfe, S., and Peacock, W. C. July 6. Parcelling cans and canisters.-In a machine for affixing labels and applying wrappers to meat tins, jam tins, or other vessels, the tins are tipped from a tray into an inclined shoot L, from which they are picked up by an elevator M and discharged at the top of an incline A. In rolling down the incline A, the tins pass over a gumming or pasting roller B, which is pivoted on arms at b<3> so as to dip into a paste box b each time a tin passes. The labels are piled on a support D, which is held up by a weighted cord d<3>. The pasted part of the tin comes into contact with the end of the label, which forthwith rolls up on the tin. The other end of the label is held down by a transverse wire E, so as to give it an inward curve before it is finally lifted. A wire F, actuated by the aforementioned roller B, supplies paste from a box to the end of the label. The label first hangs loosely from the tin, and is moistened by being dragged through a vessel G containing water. It is then rolled closely round the tin. The moistened part then picks up a wrapper from a support H, which is arranged similarly to D. The wrapper is rolled round the tin, and the extending edges are folded down by wires J and blades K.
Patent GB-189817134-A (GB)
Title: Improved Plaster Boards or Slabs for Walls, Ceilings, and the like.
Inventor: ALLISON CHARLES ARTHUR
Filed: 1898-08-09
Granted: 1898-10-22
Abstract: 17,134. Allison, C. A., [Schwartz, B. F.]. Aug. 9. Slabs or boards for walls &c. Plaster of Paris or the like a is applied to a backing or core of woven wire fabric b to form slotted or openwork slabs in which the fabric is exposed through the slots. The slabs may be made rigid, or the plaster may be divided along the lines a<2> between the slots, so that the board or slab can be rolled up, or applied to a curved surface as indicated in Fig. 8. The slabs are secured to the wall or support by the projecting wire selvages b<1>, which may overlap one another as shown in Fig. 6. Plaster is applied to the outer surface of the slabs, and forced through the slots a<1> and between the edges so as to form keys. Grooves a<3> are made in the back of the slab between the slots to receive keys of plaster. In a modification, strips of wire network are embedded in the edges of the slab only, and do not extend the whole width.
Patent GB-189822784-A (GB)
Title: Improvements in or relating to the Manufacture of Water Gas.
Inventor: LAFOND JEAN BAPTISTE
Filed: 1898-10-29
Granted: 1898-12-03
Abstract: 22,784. Lafond, J. B. Oct. 29. Gas-producers.-A water-gas generator is arranged to receive a mass of fuel in a chamber A, the combustion area being limited by supplying mixed air and steam at E and withdrawing the gases through the flue 0 in which the pipes 1 ... 8 are placed for heating the water. The steam passes by the pipe u to the mixing-chamber, from which the steam and air pass by pipe G to the furnace. The air supply is heated in the concentric pipes T, U, through which one or more pipes W convey the gases from the generator. The water supply is regulated by a valve rod n attached to the diaphragm m in the base of the air intake R, or a valve in the air-supply chamber may operate a cock in the water-supply pipe by a lever. Clinkers may be removed from the generator through the door F.
Patent GB-189822897-A (GB)
Title: An Improved Brake for Cycles.
Inventor: BUSCHMANN ERNST
Filed: 1898-10-31
Granted: 1899-02-18
Abstract: 22,897. Buschmann, E. Oct. 31. Brakes.-Figs. 1 and 3 show the application of the invention to a bicycle. The brake block b is suspended by means of levers or wires d carried by a clamp c upon the frame member a. An auxiliary lever f is pivoted to clamps g on the stay tubes e. One end of the lever f is provided with a plate which is adapted to press against the block b, and the other end is connected by a chain &c. k, passing over guide-pulleys, to the end of a lever l, Fig. 3, pivoted to a clamp m. The opposite end of the lever l is pivoted to a hand-lever n. A torsion spring keeps the lever f normally out of contact with the block b. By operating the lever n the brake is applied.
Patent GB-189824908-A (GB)
Title: An Improved Method of and Means for Attaching in Position Gas and other Bracket Blocks and the like.
Inventor: LEWIS JOHN
Filed: 1898-11-25
Granted: 1899-01-07
Abstract: 24,908. Lewis, J. Nov. 25. Brackets.-The wooden blocks i of gas and other brackets are secured by screws at d to the squared end c or to the arms e<2> of a spike or holdfast a, which has been driven into the wall g until the end c or the arms e<2> are flush with the plaster h. The arms e' may be made triangular in crosssection, to facilitate their entrance into the plaster.
Patent GB-189825856-A (GB)
Title: Improved Collapsable Tube for containing Liquid, Pasty, or Solid Substances.
Inventor: STOHR FRANZ
Filed: 1898-12-07
Granted: 1899-02-04
Abstract: 25,856. Stohr, F. Dec. 7. Drawings to Specification. Stoppers.-Collapsable tubes for containing liquids &c. are made of gelatine, and are closed by a gelatine plate which has to be perforated to empty the tube. A capsule or a clip on the neck serve to close the tube after a portion of its contents has been removed.
Patent GB-189901759-A (GB)
Title: An Improved Automatic Feed for Oil-cake Presses.
Inventor: TUCKER FRANK
Filed: 1899-01-25
Granted: 1899-02-25
Abstract: 1759. Tucker, F. Jan. 25. Moulding f o o d for animals.- Relates to means, in oilcake-making machinery, for mechanically operating the feed - box which carries the meal from the kettle to the mould. A hydraulic valve to regulate the supply of water under pressure to the mechanism for operating the feedbox is arranged so that it is actuated by gearing from the main driving- shaft. The valve, Fig. 6, consists of a rod E having a shoulder thereon and carrying a slide E'. Water under pressure is supplied by a pipe F, and leaves the valve box by a port d and pipe d<1> to actuate the feed-box. The pressure of the water on the shoulders nf the rod E tends to draw the rod downwards. The rod E is forced upwards, to uncover the port d, by a cam driven by suitable gearing from the main shaft and engaging a bowl on the top of the rod E.
Patent GB-189902188-A (GB)
Title: Improvements in and relating to Flutes.
Inventor: KLUSSMANN HENRY
Filed: 1899-01-31
Granted: 1900-01-31
Abstract: 2188. Klussmann, H., George, M. S., and Zambra, J. J. G., [trading as Rudall, Carte, & Co.]. Jan. 31. Flutes.-A flute adaptable for use as a sharp or flat pitched instrument consists of an outer tube made up of three parts with apertures, and an inner tube with two sets of holes. An open or flat flute is shown in Fig. 2, the back of the inner tube c having the small or sharp holes c<2> being shown in Fig. 3. The flute closed or sharp is shown in Fig. 4. In a slightly-modified form, the flute is provided with three extra holes.
Patent GB-189911524-A (GB)
Title: Improvements in Heels for Boots and Shoes.
Filed: 1899-06-02
Granted: 1899-07-08
Abstract: 11,524. Lake, H. H., [McKay Neverslip Sole Co.]. June 2. Heels; heel protectors; slipping, preventing.-The outer lift B of india-rubber or elastic material has embedded washers D through central apertures in which the securing-nails C are driven. The nails are entered through holes E, which are central to the wear-resisting nipples G, one of which is arranged at the back of the lift to form a solid ridge F.
Patent GB-189911646-A (GB)
Title: Improvements in Devices for Securing Incandescent Electric Lamps in their Sockets.
Inventor: RAVENE WILHELM
Filed: 1899-06-05
Granted: 1899-10-28
Abstract: 11,646. RavenÚ, W. June 5. Incandescent lamps. - A lamp bulb is made with two depressions to receive the ends of supporting- fingers a, which are pivoted on a base, and are operated by an interposed spring b. Two pins c, c<1> slide on the base and each other, and have projections engaging the fingers a, to free the lamp when they are pressed inward. The leading - in wires of the lamp terminate in knobs on the surface of the glass. Contact with these is maintained by two metal pieces fixed on an ebonite plate o, which is supported on two vertical guide-screws by springs. The guide-screws pass down to plates i, to which the supply wires are connected.
Patent GB-189912740-A (GB)
Title: Improvements in Devices for Locking the Driving Mechanism of Bicycles or Tricycles to Prevent Theft.
Inventor: TROMMER ERNST ALBIN
Filed: 1899-06-19
Granted: 1899-07-29
Abstract: 12,740. Trommer, E. A. June 19. Locks, key -Relates to locking - apparatus to prevent the theft of bicycles, tricycles, &c. The chain - wheel is loosely mounted on the crank axle, and is locked thereto by bolts which can be withdrawn by a key. Fig. 2 shows the chain-wheel disconnected from the axle. The face of the chainwheel is recessed to receive the locking-mechanism, which is carried on a disc c fixed to the axle. Two bolts d, connected by a link k, are operated by a key inserted at g, so that they can be caused to protrude through a flange c' on the disc and engage recesses f in the chain-wheel. A tumbler h with a projection i engaging slots in one of the bolts holds the bolts in place when shot or withdrawn. In a modification, the bolts are forced outwards by a spring when the tumbler is released. The number of bolts &c. may be varied.