Patent GB-878363-A (GB)
Title: Improvements relating to non-actinic preparations for the human skin
Filed: 1957-12-13
Abstract: Compounds of the general formula <FORM:0878363/IV (b)/1> in which A and B represent aromatic radicals consisting of at most 2 fused rings which can further be substituted by halogens and by groups not having dyeing characteristics such groups being bound to the aromatic rings by means of a carbon, oxygen or sulphur atom and any further aromatic radicals being linked direct or by means of saturated bridging members to A and B, and in which A is bound to the nitrogen atoms at adjacent carbon atoms, are prepared by methods known per se, for example, by coupling aryl diazonium compounds with azo compounds of the benzene and napthalene series coupling in the o-position to a primary amino group, and oxidising the o-amino-azo dyestuffs thus formed to the corresponding 1.2.3-triazole compound.  Alternatively they may be produced by coupling o-nitro aryl diazonium compounds with phenols or naphthols coupling in the o-or p-position or with amines of the benzene or naphthalene series coupling in the p-position to a primary amine group and then reducing the o-nitro-azo dyestuffs by usual methods.  The aromatic rings can be further substituted as defined and in the product free hydroxyl groups may also be alkylated or acylated.  Primary amino groups must be removed by diazotising and replacing by the usual methods with, for example, hydrogen, halogen or cyano or hydroxyl groups.  Products referred to include 2-(21-acetoxy-51-methylphenyl) - 5 - methylbenztriazole, 2 - (21-acetoxy-51-methylphenyl)-benztriazole, 2 - (21-stearoyloxy-51-methylphenyl) - benztriazole, 2-(21-benzoyloxy-51-methylphenyl) - benztriazole, 2-(21-p-tosyloxy-51-methylphenyl) - benztriazole, 2-(21-methyl-41-hydroxyphenyl)-benztriazole, 2-(21-methoxy-51-methylphenyl)-benztriazole and 2-(21-methoxy - 51 - chlorophenyl) - benztriazole.  Th products may be incorporated in nonactinic preparations for the human skin (see Group VI).ALSO:Non-actinic preparations for the human skin comprise a cosmetic base and a minor proportion of a compound of the general formula <FORM:0878363/VI/1> in which A and B represent aromatic radicals consisting of at most 2 fused rings which can be further substituted by halogen and by groups not having dyeing characteristics such groups being bound to the aromatic rings by means of a carbon, oxygen or sulphur atom and when aromatic being linked direct or by saturated bridging members to A and B, and in which A is bound to the nitrogen atoms at two adjacent carbon atoms. Examples are given of preparations containing as cosmetic bases (a) a mixture of ceresin wax, petrolatum, white mineral oil, lanolin, water and perfume; and (b) a mixture of ricinoleic acid methyl ester, oleyl alcohol and ethanol, with a minor proportion of one of the following active ingredients: (a) 2 - (21 - acetoxy - 51 - methylphenyl) - 5-methylbenztriazole; (b) 2 - (21 - acetoxy - 51-methyl phenyl) - benztriazole; (c) 2 - (21-stearoyloxy - 51 - methylphenyl) - benztriazole; (d) 2 - (21 - benzoyloxy - 51 - methyl phenyl)-benztriazole; (c) 2 - (21 - p - tosyloxy - 51-methylphenyl) - benztriazole; (f) 2 - (21 - methyl - 41 - hydroxyphenyl) - benztriazole; (g) 2 - (21 - methoxy - 51 - methyl phenyl) - benztriazole; and (h) 2 - (21 - methoxy - 51 - chlorphenyl)-benztriazole.