baber/WOPTO huggingface dataset:
Patent NZ-509966-A (NZ)
Title: Recombinant vector comprising a cassette with TET-ON under the control of a heat shock promoter, a cassette with a cloning site for a therapeutic gene, a cassette comprising antisense TET-ON and cassette with a dominative negative TET-ON and its use for metastatic prostate, breast and ovarian cancer
Inventor: FUNG YUEN KAI
IPC: A61K35/76
Filed: 1999-08-18
Abstract: A recombinant vector pDATH-X (Dominant negative, Antisense, TET-ON controllable Heat shock promoter plasmid) comprises 4 cassettes.  Cassette 1 comprises TET-ON expressed under the control of a heat shock promoter and a tet operator. The TET-ON consists of a fusion of the coding sequence for amino acids 1-207 of tetracycline repressor and the C-terminus last 130 amino acid transcription activation domain of VP1 protein of the herpes simplex virus. The heat shock promote consists of heat shock response elements (-260 to 30) of the human heat shock 70 gene promoter linked to a minimal cytomegalovirus promoter (pCMV) and the tet operator consists of 19bp inverted repeats of O2 of TN10 to which the tet repressor and TET-ON bind. Cassette 2 comprises a cloning site for a therapeutic gene downstream of a tetp-CMV promoter consisting of a tet operator linked to a minimal cytomegalovirus promoter (pCMV). The tet operator consists of 19bp inverted repeats of operator of TN10 to which the tet repressor and TET-ON bind. Cassette 3 comprises antisense TET-ON under the control of a pCMV promoter. The TET-ON is an antisense sequence complementary to the first 80 nucleotides of the TET-ON sequence. Cassette 4 comprises a dominant negative TET-ON under the control of pCMV promoter. The dominant negative TET-ON consists of tet repressor without a VP16 transactivation domain. The vector can be used in achieve localized, temporal expression of a gene that has been inserted into the vector so is under the control of a heat inducible promoter. The vector is inserted into the non-human host organism and the heat energy applier to a location of the organism where the expression of the gene is desired. Also described is a recombinant pDATE-X vector (Dominant negative, Antisense, TET-ON controllable EGR promoter expression plasmid), recombinant pRIBs-X (Radiation-Inducible Breast-specific Promoter) expression vector, recombinant pRIPs-X (Radiation-Inducible Prostate-specific Promoter) expression vector, recombinant pHIBs-X (Heat-Inducible Breast-specific Promoter) expression vector and a recombinant pHIBs-X (Heat Inducible Prostate-specific Promoter) expression vector. These vectors can be used for treating local and metastatic breast, ovarian and prostate cancer. Preferably the therapeutic gene is tumor necrosis alpha.
Patent NZ-509986-A (NZ)
Title: Immunogenic beta-propionamido-linked polysaccharide and oligosaccharide protein conjugates as vaccines
Inventor: MICHON FRANCIS
IPC: A61K47/48
Filed: 1999-08-18
Abstract: Described are immunogenic beta -propionamido-linked polysaccharide- and N-propionamido-linked oligosaccharide- protein conjugates as well as method of producing the conjugates. The conjugation procedure is applicable to a variety of polysaccharides or oligosaccharides derived from bacterial species, yeast, cancer cells or those that are synthesised chemically. Vaccines and methods of immunisation against infection or cancer using the immunogenic beta -propionamido-linked polysaccharide- and beta -propionamido-linked oligosaccharide-protein conjugates are also disclosed.
Patent NZ-510065-A (NZ)
Title: Providing two metallized holographic images on tissue, visible respectively by only coherent and non-coherent light, by laminating and delaminating
Inventor: STEPANEK MICHAEL J
IPC: G02B27/00
Filed: 2001-02-20
Abstract: The holographic element including the tissue support having at least two metallized holographic images adhered to the tissue support is provided. One of the metallized holographic images is visible by non-coherent (for example, white) light and another one of the metallized holographic images is visible only by the coherent (for example, laser) light. The metallized holographic images are transferred under heating and pressurizing the tissue support and the metallized segments of the holographic images are transferred to the tissue support. The holographic images are made to remain on a high-polymer support for recycling.
Patent NZ-510401-A (NZ)
Title: A cloned human rectal tumor cell and use thereof in a method for growing BRCV or BECV to a high antigenic mass
Inventor: STINE LISA
IPC: C12N5/06
Filed: 1998-03-04
Abstract: The cloned human rectal tumour cell, HRT-E6, designated as ATCC CRL 12478, may be used to propagate BRCV or BECV to high antigenic mass.
Patent NZ-516903-A (NZ)
Title: Composition and method for controlling biological growth using stabilized sodium hypobromite in synergistic combinations
Inventor: COOPER ANDREW J
IPC: A01N33/24
Filed: 2000-08-01
Abstract: A composition for controlling biological growth in industrial fluids comprising effective amounts of stabilized sodium hypobromite and at least one compound selected from the group consisting of coco alkyldimethylamine oxide, n-coco alkyltrimethylenediamine, tetra-alky phosphonium chloride, 7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid and 4,5-dichloro-2-n-octyl-4-isothiazoline-3-one; and a method of controlling biological growth in an industrial fluid using the said composition.
Patent NZ-518004-A (NZ)
Title: Novel phenol oxidizing enzymes
Inventor: WANG HUAMING
IPC: C12N1/21
Filed: 2000-09-11
Abstract: Phenol oxidizing enzymes naturally-produced by strains of the species Stachybotrys are disclosed. These enzymes possess pH optima in the alkaline range and are useful in modifying the colour associated with dyes and coloured compounds, as well as in anti-dye transfer applications. Also disclosed herein are biologically-pure cultures of strains of the genus Stachybotrys, designated herein Stachybotrys parvispora MUCL 38996 and Stachybotrys chartarum MUCL 38898, which are capable of naturally-producing the novel phenol oxidizing enzymes. The amino acid and nucleic acid sequence for Stachybotrys phenol oxidizing enzymes B as well as expression vectors and host cells comprising the nucleic acid are also disclosed. Methods for producing the phenol oxidizing enzyme and methods for constructing expression hosts are also discussed.
Patent NZ-518318-A (NZ)
Title: Method for distinguishing 5-position methylation changes of cytosine bases and cytosine-to-thymine mutations
Inventor: BERLIN KURT
IPC: C12Q1/6827
Filed: 2000-10-13
Abstract: Described is a method for distinguishing 5-position methylation changes of cytosine bases and cytosine-to- thymine mutations and for detecting single nucleotide polymorphisms (SNPs) or point mutations in genomic DNA, comprising the following steps: a) treating a genomic DNA-sample with sulphite or disulphite in such a way that all of the cytosine bases not methylated in the 5-position of the base are changed in such a way so as to produce a different base according to the base pairing behaviour while the cytosines which are methylated in the 5-position remain unchanged; b) quantitatively methylating an aliquot of the same genomic DNA sample before chemical treatment according to a) with Sss1 or another methyltransferase; c) testing the two DNA samples treated in this way for the presence of cytosine using the same analytical methods; and d) comparing the cytosine positions that are detected with a reference DNA-sequence.
Patent NZ-518413-A (NZ)
Title: Novel enzyme
Inventor: SQUIRRELL DAVID JAMES
IPC: C12N9/02
Filed: 2000-10-26
Abstract: A recombinant protein having luciferase activity and at least 70% similarity to a wild-type luciferase wherein in the sequence of the enzyme, the amino acid residue corresponding to residue 357 in Photinus pyralis luciferase is mutated as compared to the corresponding wild-type luciferase, such that the luciferase enzyme is able to emit light at a different wavelength as compared to the corresponding wild-type luciferase and/or has enhanced thermostability as compared to the corresponding wild-type luciferase and wherein the recombinant luciferase is other than Luc78-OB10, Luc90-1B5, disclosed in Figures 36 and 43 of WO 99/14336 as published on 25 March 1999.
Patent NZ-519256-A (NZ)
Title: A two-wire controlling and monitoring system for irrigation of localised areas of soil
Inventor: CHRISTIANSEN TOM NOHR
IPC: A01G25/16
Filed: 2000-11-15
Abstract: A two-wire controlling and monitoring system (10) for irrigation of localised areas of soil according to a aspect of the invention comprises a water pipeline (16), a first plurality of controllable irrigation valves, a second plurality of field sensors measuring specific irrigation parameters, and a third plurality of localised irrigation control units (18). The third plurality of localised irrigation control units (18) each comprises a sensor decoder connected to a specific field sensor of the second plurality of field sensors and/or a line decoder connected to a specific controllable irrigation valve of the first plurality of controllable irrigation valves. The two-wire controlling and monitoring system (10) further comprises a controller and power supply unit (30) having a set of schedules of instructions and supplying power by applying a first alternating DC voltage signal to a two-wire cable interconnecting the controller and power supply unit (30) and the third plurality of localised irrigation control units (18). The two-wire cable provides the power from the controller and power supply unit (30) to each of the third plurality of localised irrigation control units (18). The controller and power supply unit (30) transmits the schedules of instructions to the third plurality of localised irrigation control units (18) through the two- wire cable and receives the specific irrigation parameters from the third plurality of localised irrigation control units (18) through the two-wire cable.
Patent NZ-519318-A (NZ)
Title: Vascular grafts and methods for bridging a vessel side branch
Inventor: DEHDASHTIAN MARK
IPC: A61F2/06
Filed: 2000-01-19
Abstract: A vascular graft for a primary vessel adapted to bridge a side branch. The graft is especially useful for providing a support tube for a primary graft in the primary vessel on one side of the side branch. The graft includes first and second tubular sections separated by a gap. A bridging member connects the first and second tubular sections across the gap and may include a relatively rigid strut to prohibit relative axial movement of the two sections. There may be one, two or more bridging members to define one, two or more apertures through which blood can flow from within the graft through to the vessel side branch. The graft may include a flexible, desirably fabric, body supported by a wireform stent that is either self- or balloon-expandable. The graft may be deployed within the abdominal aorta on both sides of the renal arteries and have two apertures for blood to flow from the aorta to the renals. The infra-renal section provides a uniform tubular anchoring surface for a trunk portion of a bifurcated graft used to repair an abdominal aneurysm extending to the iliac arteries.
Patent NZ-520597-A (NZ)
Title: Heater assembly for blow molding plastic preforms where heater elements are at the focus of parabolic reflectors associated with each element
Inventor: SCAGLOTTI RONALD L
IPC: B29C35/08
Filed: 2001-02-06
Abstract: A heater assembly (20) for heating blow molding plastic preforms (14) includes a plurality of elongated heaters (26) mounted by a housing (24) and extending along a path of conveyance of the preforms in a parallel relationship to each other, and each heater includes an elongated parabolic reflector (44) that reflects radiation from an adjacent elongated bulb (36) to irradiate the conveyed preforms. The heater assembly (20) also includes a quartz window (58) located between the elongated heaters (26) and the conveyed preforms (14) to transmit infrared radiation while blocking longer wavelength radiation so as to provide uniform heating of the conveyed preforms
Patent NZ-522089-A (NZ)
Title: Magnetic thin film interference device or pigment and method of making it, printing ink or coating composition, security document and use of such a magnetic thin film interference device
Inventor: SETO MYRON
IPC: B32B7/00
Filed: 2002-02-14
Abstract: A magnetic thin film interference device consisting of thin-layer flakes having a basic metal-dielectric-metal structure, resulting in a viewing-angle dependent colour appearance, is disclosed. The device includes a multi-layer stack that includes at least one light reflecting layer 3, 3', at least one light transmitting dielectric layer 2, 2', at least one light absorbing layer 1, 1', and at least one magnetic layer 4. A magnetic layer 4 is separated from a dielectric layer by a reflector layer. The invention also discloses methods for obtaining optically variable pigments from the interference device and the use of these pigments as security elements in inks, coatings and articles.
Patent NZ-522181-A (NZ)
Title: 3-nitrogen-6,7-dioxygen steroids and uses related thereto
Inventor: SHEN YAPING
IPC: A61P17/02
Filed: 2001-04-30
Abstract: 3-nitrogen-6,7-dioxygen steroids of formula (I) and pharmaceutical acceptable salts, solvates, stereoisomers and prodrugs thereof, in isolation or in mixture are disclosed, wherein, independently at each occurrence: R1 and R2 are selected from hydrogen, oxygen so as to form nitro or oxime, amino, sulfate, and sulfonic acid, and organic groups having 1-30 carbons and optionally containing 1-6 heteroatoms selected from nitrogen, oxygen, phosphorous, silicon, and sulfur, where R1 and R2 may, together with the N to which they are both bonded, form a heterocyclic structure that may be part of an organic group having 1-30 carbons and optionally containing 1-6 heteroatoms selected from nitrogen, oxygen and silicon, and where R1 may be a 2, or 3 atom chain to numeral 2 so that -N-R1- forms part of a fused bicyclic structure to ring A; R3 and R4 are selected from direct bonds to 6 and 7 respectively so as to form carbonyl groups, hydrogen, or a protecting group such that R3 and/or R4 is part of hydroxyl or carbonyl protecting group; numerals 1 through 17 each represent a carbon having substitution as defined in the specification. These compounds may be formulated into pharmaceutical compositions, and used in the treatment and/or prevention of various conditions, including inflammation, asthma, an allergic disease, chronic obstructive pulmonary disease, atopic dermatitis, solid tumors, AIDS, ischemia, and cardiac arrhythmias.
Patent NZ-522217-A (NZ)
Title: Cyclic compounds
Inventor: YAMADA KOICHIRO
IPC: C07D401/12
Filed: 2001-03-15
Abstract: A cyclic compound of formula (I) exhibiting a cGMB specific phosphodiesterase (PDE) inhibitory activity (PDE V inhibitory activity) and being useful as a medicament for treating erectile dysfunction.
Patent NZ-524433-A (NZ)
Title: Xanthine phosphodiesterase V inhibitors
Inventor: CHACKALAMANNIL SAMUEL
IPC: A61P37/06
Filed: 2001-09-17
Abstract: Disclosed are xanthine compounds of formula (I) for which the substituents are defined herein. The compounds are used in the manufacture of medicaments for the treatment of diseases mediated by the inhibition of phosphodiesterase V (PDE V), such as erectile dysfunction.
Patent NZ-525439-A (NZ)
Title: Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors
Inventor: WATKINS CLARE J
IPC: C07D209/88
Filed: 2001-09-27
Abstract: A compound of formula:  A-Q1-J-Q2-CO-NH-OH pertaining to certain active carbamic acid compounds which inhibit HDAC activity where: - A is an aryl group; - Q1 is a covalent bond or an aryl leader group; - J is a sulfonamide linkage selected from: -S(O)2NR1-; - R1 is a sulfonamido substituent; and, - Q2 is an acid leader group; - A, is a C5-20aryl group, and is optionally substituted; - the aryl leader group, if present, is: - a C1-7 alkylene group and is optionally substituted; - the sulfonamido substituent, R1 is hydrogen, C1-7alkyl, C3-20heterocyclyl, or C5-20aryl ; - the acid leader group, Q2, is phenylene C1-7alkylene; or C1-7alkylene-phenylene; and is optionally substituted. The phenylene linkage is meta. Compounds of formula (1) may inhibit HDAC and proliferative conditions, such as cancer and psoriasis.
Patent NZ-526890-A (NZ)
Title: Transparent paramagnetic polymer for labels that cannot be detected optically
Inventor: DEAN DAVID M
IPC: C08F2/46
Filed: 2002-01-16
Abstract: A transparent, paramagnetic polymer composition is disclosed, in which a polymer is complexed with sufficient rare earth ions, particularly ions selected from ions in the group of elements 64 - 69, to provide a polymer with a magnetic mass susceptibility greater than 20 x 10-6 emu/g measured at 298 DEG K. Also disclosed are optically responsive devices that employ these transparent, paramagnetic polymers as an element that is responsive to a magnetic field and a means for providing magnetic field. This transparent, paramagnetic polymer composition is used for making transparent labels or markings that cannot be optically detected by a person with 20/20 vision from a distance of 3 feet or more.
Patent NZ-526917-A (NZ)
Title: Method of protecting ink and providing enhanced bonding during molding of lenticular lens sheets in plastic objects
Inventor: GUEST RICHARD
IPC: G02B30/27
Filed: 2001-06-13
Abstract: A method of fabricating plastic products with an integrated Lenticular lens material that thermally protects the ink layer and outer lens surfaces of the Lenticular insert. A Lenticular lens material is provided with a Lenticular lens layer with an outer surface of optical ridges (22) and an ink layer (28) bonded to a transparent lens layer (24). A thermal protective substrate (30) comprising opaque flexographic ink is applied to the ink layer. The application of the thermal protective substrate is completed using a coating unit of a lithographic press. A Lenticular insert is formed from the coated Lenticular lens material and the insert is positioned within a mold cavity. The thermal protective substrate insulates the ink layer. Concurrently, the portion of the mold adjacent the insert is cooled to a temperature below the deformation temperature of the optical ridges.
Patent NZ-527277-A (NZ)
Title: Hydrogel wound dressing, preparation and use thereof
Inventor: MCGHEE DIANE
IPC: A61P17/02
Filed: 2002-01-30
Abstract: Described is a hydrogel composition comprising from 5 to 30 percent by weight of a polyurethane prepolymer, from 3 to 45 percent by weight of one or more alcohols selected from the group consisting of polyethylene glycol, polypropylene glycol and polypropylene glycol, and the balance water, accelerator and an additive, characterized in that said additive is one or more of the following: -an anti-microbial agent selected from the group consisting of chlorhexidene acetate, chlorhexideine gluconate, chlorhexidene hydrochloride, chlorhexidine sulfate, silver, silver acetate, silver benzoate, silver carbonate, silver iodate, silver iodide, silver lactate, silver laurate, silver nitrate, silver oxide, silver palmitate, silver protein, polymyxin, tetracycline, tobramycin, gentamicin, rifampician, neomycin, chloramphenicol, oxolinic acid, norfloxacin, nalidix acid, pefloxacin, enoxacin, ciprofloxacin, ampioillin, amoxicillin, piracil, cephalosporins, and vancomycin -an anti-fungal agent selected from the group consisting of Tolnaftate, Miconazole, Fluconazole, Econazole, Ketoconazole, Itraconazole, Terbinafine, Amphotericin, Nystatin and Natamycin -an organic additive agent selected from the group consisting of Grapefruit Seed Extract, Tea Tree Oil, Myrtle Oil, and Lemon grass extract. A method of producing the hydrogel composition is also disclosed.
Patent NZ-529780-A (NZ)
Title: A coated nicotine-containing chewing gum, manufacture and use thereof
Inventor: LINDELL KATARINA
IPC: A61P25/28
Filed: 2002-06-14
Abstract: Described is a coated chewing gum product for the delivering of nicotine in any form to a subject by a rapid transmucosal uptake in the oral cavity comprising at least one gum core, nicotine in any form and/or a nicotine mimicking agent, at least one coating layer and optionally at least one or more other additive, wherein the coating layer is buffered. Also contemplated is a method for the delivering of nicotine in any form, a method for the reduction of the urge to smoke or use tobacco as well as a method for producing the coated chewing gum and the use of the same form obtaining a quick transmucosal uptake of the nicotine in the oral cavity of a subject.
Patent NZ-531587-A (NZ)
Title: A lamp and method of producing a lamp
Inventor: JEGANATHAN BALU
IPC: F21K99/00
Filed: 2003-06-11
Abstract: A lamp and a method of producing a lamp is disclosed. The method includes the steps of (a) mounting light emitting junctions in respective electrically conductive receptacles (2); (b) mounting the receptacles with light emitting junctions mounted therein on a portion of a lead frame so as to form a three-dimensional array of receptacles (2) in electrical connection with the lead frame; and (c) forming electrical connections between the light emitting junctions and the lead frame.
Patent NZ-533786-A (NZ)
Title: Fluoro substituted cycloalkanoindoles, compositions containing such compounds and methods of treatment
Inventor: BERTHELETTE CARL
IPC: A61P37/08
Filed: 2003-01-22
Abstract: Disclosed are compounds of formula I, wherein: n is 0 or 1, m is 1, R1 is H, C1-3alkyl, halogenated C1-3alkyl, or cyclopropyl, R2 is 4-chlorophenyl or 2,4,6-trichlorophenyl. The compounds are used for the manufacture of medicaments for the treatment of prostaglandin D2 mediated diseases, such as nasal congestion, allergic asthma, or allergic rhinitis.
Patent NZ-535381-A (NZ)
Title: 5HT2c receptor modulators to treat obesity in a mammal
Inventor: SMITH BRIAN
IPC: C07D223/14
Filed: 2003-04-11
Abstract: Disclosed herein are compounds of formula (I) which act as 5HT2C receptor modulators, wherein the variables are as defined in the specification. These compounds are useful in pharmaceutical compositions whose use includes the treatment of obesity.
Patent NZ-537388-A (NZ)
Title: Grate structure for solid fuel burners
Inventor: WILLIAMS PAUL DOUGLAS
Filed: 2001-12-21
Abstract: A solid fuel gasifier includes a grate structure 22, 24 within the gasifier chamber 14. The grates include fixed grate plates 30 and reciprocating grate plates 32 supported to be aligned at an angle to the vertical and horizontal. The plates 32 are reciprocated by the drive mechanism 62, 63. A deep burden of solid fuel (see profile 70) from the fuel inlet 9, 21 accumulates on the grate structure and the reciprocation of the grate plates moves the fuel burden in an overall horizontal flow along the grate structure whilst "stirring" the solid fuel to assure efficient combustion and gasification of the fuel.
Patent NZ-537532-A (NZ)
Title: Testing device
Inventor: PICTON DAVID JOHN
Filed: 2004-12-24
Abstract: A testing device comprising a substantially hollow tube having a thread at both ends; an inner end being provided with a male thread and a flange supporting a seal so that when the male thread is inserted into a female wingback in use the flange compresses the seal against the wingback with the objective of preventing any fluid leakage at the junction; and at the outer end there is an internal or external thread with an internal sealing chamfer at its tip; and there are grip means provided between the two threaded ends.