baber/WOPTO huggingface dataset:
Patent CR-20110202-A (CR)
Title: Antagonistas de la via hedgehog de ftalazina disustituida
Inventor: BASTIAN JOLIE ANNE
IPC: A61K31/502
Filed: 2011-04-15
Abstract: La presente invención provee antagonistas de la vía hedgehog de ftalizina 1,4-disustituida novedosos útiles en el tratamiento de cáncer.
Patent CR-20150665-A (CR)
Title: Complemento de hierro
Inventor: BORTZ JONATHAN DAVID
IPC: A61P39/04
Filed: 2015-12-17
Abstract: Un sistema de dosis suministrable oralmente comprende (a) hierro en una forma de uno o más compuestos y/o complejos, grado de hierro aceptable fisiológicamente; y (b) un agente para mitigar uno o más efectos adversos gastrointestinales de hierro no absorbido, el agente que comprende uno o tanto el componente de zinc y un componente quelante, el componente de zinc si está presente comprende uno o más compuestos y/o complejos de zinc aceptables fisiológicamente y el componente quelante si está presente comprende un compuesto quelante de hierro formulado para liberación distal al sitio primario de absorción de hierro en el duodeno.
Patent CR-20180229-A (CR)
Title: Conjugados de anticuerpos que comprenden un agonista del receptor tipo toll
Inventor: GEIERSTANGER BERNHARD HUBERT;
IPC: C07D473/34
Filed: 2016-10-25
Abstract: Se proporcionan en la presente, conjugados de anticuerpos que comprenden agonistas del receptor tipo toll y el uso de tales conjugados para el tratamiento de cáncer. En algunas modalidades, los conjugados comprenden anticuerpos anti-HER2.
Patent CR-20190101-A (CR)
Inventor: Tang Kim
IPC: C07D487/04
Filed: 2017-09-01
Abstract: La presente descripción hace referencia a estimuladores de la guanilato ciclasa soluble (sGC), formulaciones farmacéuticas que los comprenden y sus usos, en solitario o en combinación con uno o más agentes adicionales, para el tratamiento de diversas enfermedades, donde sea conveniente un aumento de la concentración de óxido nítrico (NO) y/o un aumento de la concentración de guanosín monofosfato cíclico (cGMP), o una regulación positiva de la vía de NO. Los compuestos son de Fórmula IThe present disclosure relates to stimulators of soluble guanylate cyclase (sGC), pharmaceutical formulations comprising them and their uses thereof, alone or in combination with one or more additional agents, for treating various diseases, wherein an increase in the concentration of nitric oxide (NO) or an increase in the concentration of cyclic Guanosine Monophosphate (cGMP), or both, or an upregulation of the NO pathway is desirable. The compounds are of Formula (I).
Patent DK-8600213-A (DK)
IPC: G21C19/19
Abstract: A ball-bed (pebble-bed) nuclear reactor, instead of having fuel elements more or less continuously withdrawn and new or reconstituted fuel elements more or less continuously reintroducted, is initially partly filled with fuel balls of which two-thirds have a fissionable material content 12% below and the upper third 24% higher than the average content. This filling meets the requirements of criticality in order to begin operation. Thereafter, fuel balls are added slowly, a few hundred per day, having 150 to 250% of the average fissionable material content of the initial loading, thus preserving the criticality requirments, while keeping the temperature within safe limits until the reactor cavern is filled. Thereafter, the reactor is shut down, cooled off, pressure relieved and emptied, the last step typically from above. An ordered array of the fuel balls in regular layers avoids excess pressure loads on the reflector over the life time of the filling. For a random packing of the balls a cross-section of the cavern that increases somewhat from the bottom upwards also avoids the excess pressure loads on the reflector.
Patent EC-SP056148-A (EC)
Title: Compuestos inmunosupresores y composiciones
Inventor: PAN SHIFENG
IPC: B29C65/50
Filed: 2005-11-10
Abstract: La presente invención se refiere a inmunosupresores, a procesos para su producción, a sus usos y a composiciones farmacéuticas que los contienen. La invención proporciona una clase novedosa de compuestos útiles en el tratamiento o en la prevención de enfermedades o trastornos mediados por las interacciones de los linfocitos, en particular las enfermedades asociadas con la transducción de señal mediada por el receptor de EDG
Patent EC-SP931014-A (EC)
Title: Vidrio laminado curvo de mayor seguridad y metodo para producirlo
Inventor: MANNHEIM JOSE RICARDO
IPC: B32B/
Filed: 1993-12-22
Abstract: Un método de fabricación de una laminado curvo de mayor seguridad el cual comprende los siguientes pasos: Proporcionar un laminado por capas que comprende por lo menos una capa de vidrio curvo seleccionado del grupo consistente de vidrio templado, semitemplado, o recocido y por lo menos una capa curva de material plástico laminada con una capa de material adhesivo, ensamblar un molde curvo rígido duro, estructuralmente estable, formado de un material que no se adhiera al laminado y con la misma curvatura y topografía que la capa de vidrio curvo, sujetada a presión contra la capa plástica curva, para proteger la capa plástica contra la deformación y prevenir la formación de aire atrapado en el adhesivo durante el calor subsecuente, durante el material del molde se selecciona de un grupo consistente de plástico y metal; someter el laminado ensamblado y el molde a un vacío, calor y presión para formar el laminado; enfriar el laminado y el molde bajo dicha presión; y remover el molde del laminado.
Patent EC-SP972243-A (EC)
Title: Radiotelefono portatil con tapa deslizable y extension de antena automatica
Inventor: PENLAND JOE E
IPC: H04M1/03
Filed: 1997-08-29
Abstract: De acuerdo con un aspecto, un radioteléfono portátil que comprende una caja, una tapa unida en forma deslizable a la caja y alternable en forma selectiva en relación con la caja entre una primera posición, en la que el radioteléfono portátil se encuentra colgado y en forma alternativa, una segunda posición, en la que el teléfono se encuentra descolgado. De acuerdo con otro aspecto, el radioteléfono portátil comprende una caja, una tapa unida en forma deslizable a la caja y alternable en forma selectiva en relación con la caja entre una primera posición y, en forma alternativa, una segunda posisción en la que por lo menos una parte de la tapa se extiende hacia afuera más alla de la caja, y una antena fija a la tapa y que se extiende a lo largo de este, y por lo menos una parte de la antena se extiende hacia afuera más alla de la caja cuando la tapa se encuentra en la segunda posición. El radioteléfono portátil evita la pulsación accidental de teclas y la desconexión accidental de llamadas telefónicas al contestar y permite con mayor facilidad lograr el máximo desempeño del telefono celular durante las llamadas.
Patent FI-20002311-A (FI)
Inventor: MATTILA MIKA I
IPC: H04L12/24
Filed: 2000-10-19
Abstract: The invention relates to a method of managing network element (NE) settings in a communications network. The invention comprises defining a proxy (AC) for the network element (NE) to be managed; loading information on the present settings of said network element (NE) to said proxy (AC); loading information on the new settings of said network element (NE) to said proxy (AC); comparing the new settings of the network element (NE) with its present settings in the proxy (AC); and if the new settings of the network element (NE) differ from its present settings, generating management operations in the proxy (AC) for replacing the present settings with the new settings in the network element (NE); and updating the new settings to the network element (NE) by means of said management operations at the moment determined by the network management element.
Patent GB-1047420-A (GB)
IPC: A01N47/04
Abstract: 1,047,420. Sulphenic acid derivatives. FARBENFABRIKEN BAYER A.G. Oct. 13, 1965 [Nov. 17, 1964], No. 43405/65. Heading C2C. [Also in Division A5] The invention comprises the sulphuric acid derivative of the formula and a process for the preparation thereof wherein N - trifluoromethyl - (2 - methyl - 5 - nitro - aniline) is reacted with fluorodichloromethane-sulphenyl chloride in the presence of a tertiary amine. An example is furnished. The product is employed as active principle in fungicidal compositions (see Division A5).
Patent GB-1051898-A (GB)
IPC: H01F27/26
Abstract: 1,051,898. Transformers. LICENTIA PATENT-VERWALTUNGS-G.m.b.H. July 10. 1964 [July 11, 1963], No. 28557/64. Heading HIT. A coil clamping member 1 for a transformer or reactor is anchored by a pin or pins to a limb clampi ng plate 4. A spacing plate or cooling passage strips 6 allow room for adjustment of the yoke 7. An alternative construction is described (Fig. 3. not shown).
Patent GB-1230206-A (GB)
IPC: H02H9/04
Filed: 1968-11-12
Abstract: 1,230,206. Protective arrangements. ROBAND ELECTRONICS Ltd. 21 May, 1969 [12 Nov., 1968], No. 53571/68. Headings H2H and H2K. When the voltage across D.C. supply lines 2, 3 exceeds a first predetermined value a first current path, e.g. a transistor 15, is rendered conductive to limit the rise in voltage and should the voltage remain above the predetermined value for a predetermined time then a second current path, e.g. an SCR 20, conducts to cause a larger current to flow to effect the operation of an overcurrent protective device, e.g. the blowing of a fuse 4. In the arrangement shown, when the voltage at the junction of resistors 5, 6 sufficiently exceeds a voltage determined by a Zener diode 8, a transistor 7 conducts and causes a transistor 11 to conduct, so that the transistor 15 is rendered conductive and a capacitor 18 commences to charge. At the end of the predetermined time, the voltage across the capacitor is sufficient to turn on the SCR 20. Should however a sudden large increase in the voltage occur, a Zener diode 22 breaks down to turn on the SCR 20 without delay.
Patent GB-1230492-A (GB)
IPC: B27B5/24
Filed: 1969-02-17
Abstract: 1,230,492. Circular saw bench. DODD MACHINE TOOLS Ltd. 17 Feb., 1970 [17 Feb., 1969], No. 8452/69. Heading B5L. A saw bench comprises a table 2, a vertically adjustable slide 8 below the table and carrying a motor 15 and circular saw 3, lever actuated means for adjusting the vertical position of the slide to vary the area of the saw projecting above the table, and means for locking the slide in any desired position. As described the table 2 forms the top of a housing 1 which supports a casting 10 on which the slide 8 is vertically slidable. A lever 6 and a crank 19 are secured to a shaft 5 pivotable about a fixed horizontal axis, and the crank is connected to the slide 8 by a link or links 20 so that pivoting of the lever adjusts the vertical position of the slide. A shaft 11 threaded in the casting 10 passes through a slot 12 in the slide 8 and carries at one end a handle 7 and at the other nuts 13, 13<SP>1</SP>. Rotation of the shaft 11 by the handle 7 causes the nuts 13, 13<SP>1</SP> to clamp the slide 8 against the casting 10 to lock it in position. A helical torsion spring on the shaft 5 may serve to carry at least some of the weight of the slide, saw, and motor. The table 2 may carry a rip fence, mitre attachment, and saw guard.
Patent GB-1233375-A (GB)
IPC: C07D487/04
Filed: 1967-10-26
Abstract: 1,233,375. Phenazine derivatives. MAY & BAKER Ltd. 12 Sept., 1968 [26 Oct., 1967], No. 48797/67. Heading C2C. [Also in Division A5] Novel phenazine derivatives of Formula I in which (a) R<SP>1</SP> is isopropyl or phenyl, R<SP>2</SP> is 8- methoxy and R<SP>3</SP> is phenyl; or (b) R<SP>1</SP> is isopropyl or cyclohexyl, R<SP>2</SP> is 8-chloro and R<SP>3</SP> is phenyl; or (c) R1 is phenyl, R<SP>2</SP> is 7-methoxy and R<SP>3</SP> is phenyl or p-chlorophenyl, are prepared (i) when R<SP>1</SP> is phenyl, by reacting an ophenylene-diamine of Formula II in which R<SP>21</SP> is 4- or 5-methoxy, and R<SP>3</SP> is i phenyl or, when R<SP>2</SP> is 5-methoxy, p-chlorophenyl, with 4,5-dianilino-o-benzoquinone; or (ii) when R<SP>3</SP> is phenyl and R<SP>1</SP> is isopropyl or cyclohexyl, by oxidizing a phenazine of Formula III in which R<SP>1#1</SP> is isopropyl or cyclohexyl, and R<SP>2#11</SP>  is Cl or, when R<SP>11</SP> is isopropyl, methoxy; or (iii) when R<SP>1</SP> and R<SP>3</SP> are phenyl, by reacting aniline with a phenazine of Formula IV   in which R<SP>2#111</SP> is 7- or 8-methoxy. Imidazophenazines of Formula V in which R<SP>4</SP> and R<SP>5</SP> are methyl or, together with the carbon atom to which they are attached,   form a cyclohexyl group and R<SP>2#11</SP> is chlorine or, when R<SP>4</SP> and R<SP>5</SP> are methyl, methoxy, are prepared by oxidizing a salt of an o-phenylenediamine of Formula II, e.g. with benzoquinone, in the presence of a ketone of formula R<SP>4</SP>R<SP>5</SP> C = O. 4 - Methoxy -, 5 - methoxy -, 4 - chloro - and 41 - chloro - 5 - methoxy - diphenylamine hydrochlorides are prepared by reduction of the corresponding nitro compounds, followed by salification. 5 - Methoxy - 2 - nitrodiphenylamine is prepared by reacting 5-chloro-2-nitrodiphenylamine with sodium methoxide.
Patent GB-1233476-A (GB)
IPC: H03K19/09
Filed: 1969-08-14
Abstract: 1,233,476. Transistor logic circuits. INTERNATIONAL BUSINESS MACHINES CORP. 14 Aug., 1969 [11 Sept., 1968], No. 40725/69. Heading H3T. A circuit for producing an output when up to M out of N signals are present (M#0) comprises means (1OA-10N) for producing a first output having an amplitude representing the number of signals present, means (18) for producing main output in response to the first output, threshold means (16) having one terminal connected to the first output and another to further means 20 responsive when the threshold is exceeded by a number of signals exceeds N to remove the main output. Thus as shown the sum of the input signals is passed to the output until the threshold of the Zener diode is exceeded whereupon the output is shorted to earth by the transistor. In a two input circuit the exclusive e OR function is performed (Fig. 1, not shown).
Patent GB-1233764-A (GB)
IPC: B03C7/00
Filed: 1968-07-30
Abstract: 1,233,764. Electrostatic separation of solid particles. SOC. DE PRODUITS CHIMIQUES D'AUBY. 30 July, 1968 [8 Aug., 1967], No. 36353/68. Heading C1A. Solid mineral particles are separated by treating the particles with a cationic surfaceactive substance, fluidizing the treated particles and submitting the fluidized particles to the action of an electrostatic field-type separator. The cationic substance is an amine, a polyamine, an amine or polyamine derivative or a mixture of any of these. The cationic substances are incorporated in an amount between 20-100 grams per ton of solid material. Examples of amine derivatives which may be used are salts, amino acids, quaternary salts, oxyethylated amines and derivatives obtained by the condensation of a fatty acid and a short chained polyamine, the short chained polyamine being an amido amine or an imidazolone.
Patent GB-1234413-A (GB)
IPC: B01D46/24
Filed: 1968-08-07
Abstract: 1,234,413. Gas filter. UNITED FILTRATION CORP. 7 Aug., 1968 [10 Aug., 1967], No. 37754/68. Heading B1T. Air to be filtered is directed from an inlet 12 partly onto the outer surface of an outer tubular filter element 58 and partly onto the inner surface of an inner tubular filter element 60, for flow in parallel to an outlet 30. As described, air flows in tangentially at 12 and some dust is deposited centrifugally onto the housing wall, whereby it can be discharged periodically at 44. A shield 46 protects part of element 58 to promote uniform flow distribution. One stream of air passes directly to outlet 30 through element 58 and annular chamber 61; the other passes through annular chamber 59, through holes 50 in a tube 48, into the central bore 100, through element 60 and chamber 61 to outlet 30. One end cap 14 is removable (being secured by latches 32) to permit removal of the composite filter element. The ends of elements 58, 60 are bonded to caps 52, 64 by a plastisol. The outer element 58 is sealed to member 18 by gasket 62. The filter is suitable for use with an internal combustion engine air intake.
Patent GB-1250706-A (GB)
IPC: H01R24/52
Filed: 1969-04-10
Abstract: 1,250,706. Two-part couplings. V-M CORP. 10 April, 1969 [6 May, 1968], No. 18547/69. Heading H2E. Two bosses 12, 12<SP>1</SP>, integral with a plate 10, have, on their outsides, interconnected earthng surfaces, at least one of the bosses containing an electrical connector. As shown, both bosses are formed in the same metal plate and the boss 12 contains an insulating sleeve 20 located by projections 28 extending through slots in the boss. Alternatively, (Fig. 3, not shown) the boss may be open-topped, the sleeve having projections engaging both ends. The sleeve contains a contact 38 treated by lances 40 for connection with a pin 48 of a connector having earth contacts 52 engaging the outside of the boss. The plate 10 and the integral bosses may be of insulating material (Figs. 6-8, not shown), a separate earthing contact common to the adjacent surfaces of both bosses being provided on the outsides thereof, each boss containing a connector contact. Again, an insulating plate may be formed with a boss containing a connector contact and an adjacent solid boss interconnected earth coatings being provided on the facing surfaces of the two bosses (Fig. 9, not shown).
Patent GB-1251444-A (GB)
IPC: F24D3/10
Filed: 1969-02-26
Abstract: 1,251,444. Hot water tanks. E. K. M. ELORANTA, and A. A. ELORANTA, [trading as MATTI ELORANTA & CO.]. 26 Feb., 1969 [26 Feb., 1968], No. 10291/69. Heading F4A. A storage tank 5 for a central heating system which also supplies warm utility water is divided by a flexible membrane 6 into a water compartment 9 and a gas compartment 8, the water compartment containing a calorifier 4 and the gas compartment being filled with gas, e.g. nitrogen, under pressure to enable the storage tank to act also as an expansion tank. Hot water rises from the boiler 1 to the storage tank 5 through a pipe 7 which is bent away from the membrane 6 to give the membrane room to move, and the water cooled by the calorifier 4 returns to the boiler through a pipe 2.
Patent GB-1252024-A (GB)
IPC: F16L3/12
Filed: 1969-01-13
Abstract: 1,252,024. Clamps. W. P. SCHMITT. 13 Jan., 1969 [14 March, 1968], No. 1952/69. Heading E2B. A band clamp comprises a body part 51 adapted to be fixed to a support 54 by means of a pin or screw 53 passed through an opening 52 in the body part 51, and a flexible tie 50 having one end fixed to the body part and a free end provided with a fastening element 57 for engagement with a complementary element 58 on the body part, the opening 52 in the body part being provided in a central portion 62 connected to an outer portion 63 through a collar forming a relatively thin membrane 64. As shown the membrane 64 allows the portion 62 to follow any misalignment due to the pin or screw being driven in askew.
Patent GB-1256530-A (GB)
IPC: C07D277/80
Filed: 1968-12-30
Abstract: 1,256,530. Benzothiazole sulphenamides. AMERICAN CYANAMID CO. 30 Dec., 1968 [2 Jan., 1968], No. 61736/68. Heading C2C. Sulphenamides of the formula in which R is hydrogen, C 1-8  alkyl or C 1-8  hydroxyalkyl, R<SP>1</SP> is C 1-8  alkyl, C 1-8  hydroxyalkyl or cycloalkyl or R and R<SP>1</SP> together complete a heterocyclic ring, are prepared by reacting, in the absence of free ammonia, equimolar amounts of 2-mercaptobenzothiazole or 2,2<SP>1</SP>- dithio-bis-benzothiazole and an N-chloroamine ClNRR<SP>1</SP> in the presence of an inert solvent and sufficient of the free amine HNRR<SP>1</SP> to neutralize HC1 evolved during the reaction, the N- chloroamine being added to the benzothiazolyl reactant while maintaining an excess of said benzothiazole in the reaction mixture. It is preferred to conduct the reaction in the presence of an anhydrous alkali metal or alkaline earth metal compound at 0-80‹ C. Examples describe the preparation of 2-(morpholinothio)- benzothiazole, N - cyclohexyl - 2 - benzothiazole - sulphenamide and N - (t - butyl) - 2- benzothiazole-sulphenamide.
Patent GB-1258092-A (GB)
IPC: B29C55/00
Filed: 1969-01-14
Abstract: 1,258,092. Preserving food &c. UNION CARBIDE CORP. 14 Jan., 1969 [18 Jan., 1968], No. 2214/69. Heading A2D. [Also in Divisions B5, B8 and C3] A plastics film capable of withstanding the temperature of liquid nitrogen (e.g. as low as -195.8‹C) enables viable and perishable materials to be packaged in such film and to be preserved and stored at very low temperatures. Perishable materials referred to are blood, blood platelets, other components of human and animal organs, semen, tissues and cultures; fresh fruits, vegetables and meats are also mentioned. The film is obtained from a polymer composition containing at least 50% by weight of polyethylene or polypropylene, the remainder of the composition being acrylic acid, methacrylic acid, vinyl acetate, ethyl acetate, butylene or neohexene, copolymerised with the olefin, or a polymer thereof blended with the polyolefin, said polymer composition having an intrinsic viscosity in decalin at 130‹C of at least 1.2, the film having been biaxially oriented to such an extent that it has been stretched to a minimum stretch ratio of 3:1 in both the longitudinal and transverse directions.
Patent GB-1258815-A (GB)
IPC: E02F3/92
Filed: 1969-04-11
Abstract: 1,258,815. Sub-aqueous mining. B. A. BOYLE and L. W. BOYLE. 11 April, 1969 [2 May, 1968], No. 18673/69. Heading E1F. Apparatus for sub-aqueous mining comprises a suction head, a source of high pressure air connected via a supply hose to a suction pump in the head and a product hose to transmit particulate material in a slurry from the head to the shore or to a floating barge or ship. The pump may be of the type disclosed in Specification No. 1,258,814. The air source may be an air compressor mounted on a barge above the head, and may also power jet pumps in the head to scan the head over the seabed. One or more television cameras and lamps may be mounted on the head.
Patent GB-1265077-A (GB)
IPC: A63F7/00
Filed: 1969-06-20
Abstract: 1,265,077. Apparatus for playing an indoor game. COLLON CO. Ltd. and R. H. WOTTON. 8 May, 1970 [20 June, 1969], No. 31283/ 69. Heading A6H. Apparatus for use in playing a game comprises a striker 8 which is manually operated to propel a ball 13 along a spiral track 4 and simultaneously rotates a random selection disc 10 which indicates a chance or hazard for example to indicate a possible modification of the position indicated by the ball. The spiral track 4 is mounted on a transparent support 2 which forms the upper wall of a pocket into which cards may be inserted. The disc is rotated by means of a resilient tyre 12 on its outer edge which engages a projection 9 on the striker.
Patent GB-1265698-A (GB)
IPC: B22F3/00
Filed: 1969-09-30
Abstract: 1,265,698. Filling press dies. MANNESMANN-MEER A.G. 30 Sept., 1969 [2 Oct., 1968], No. 47898/69. Heading B5A. [Also in Division F2] A die in a platen 1 of a powder compacting press, is filled from an open bottom filling shoe 23 which linearly reciprocates in sliding contact over the upper platen surface between positions displaced from, and over the die, whereat the shoe 23 then moves in an elliptical filling orbit whilst in filling communication with the die. The elliptical movement of the shoe 23 in the filling position is obtained from a crank-pin 16 of an arm 14, which rotates on a shaft 12 carried by a support 7, and the connecting-rod 19 whereof carries the shoe 23 at its other end and is mounted intermediate its end at a pivot pin 25 which is linearly slidingly displaceable in the support 7. The shaft 12 is rotated by a motor 9 attached to a housing 6 fixed to the support 7 The linear reciprocating movement of the shoe 23 into and out of its filling position is obtained from a cylinder 3, the piston-rod 5 whereof is connected to the housing 6 to slidingly displace the support 7 within guides 8 mounted to the platen 1. The pin 16 is positionally adjustable within a slot 15 of the arm 14. The shoe 23 is carried by a yoke 22 pivotally supported at 21 by the rod 19, whereby the shoe 23 is freely movable about perpendicularly related horizontal axes to follow irregularities in the platen surface over which it slides and against which it is urged by a spring 32 mounted on the pivot-pin 25.