baber/WOPTO huggingface dataset:
Patent NZ-527768-A (NZ)
Title: CCR5 antagonists useful for treating AIDS
Inventor: MILLER MICHAEL W
IPC: A61P31/18
Filed: 2002-03-27
Abstract: Compounds of the formula (I) or a pharmaceutically acceptable salt or isomer thereof, pharmaceutical compositions and combinations with antiviral or anti-inflammatory agents that are suitable for the treatment of HIV, solid organ transplant rejection, graft v. host disease, inflammatory diseases, atopic dermatitis, asthma, allergies or multiple sclerosis are disclosed, wherein: Q, X and Z are CH or N; R, R4-R7 and R13 are H or alkyl; R1 is H, alkyl, fluoroalkyl, R9-arylalkyl, R9-heteroarylalkyl, alkyl-SO2-, cycloalkyl-SO2-, fluoroalkyl-SO2-, R9-aryl-SO2-, R9-heteroaryl-SO2-, N(R22)(R23)-SO2-, alkyl-C(O)-, cycloalkyl-C(O)-, fluoroalkyl-C(O)-, R9-aryl-C(O)-, NH-alkyl-C(O)- or R9-aryl-NH-C(O)-; R2 is H and R3 is H, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, R9-aryl, R9-arylalkyl, R9-heteroaryl, or R9- heteroarylalkyl, and when X and Z are each CH, R3 is alkoxy, R9-aryloxy, R9-heteroaryloxy, alkyl-C(O)O-, alkylamino- C(O)O-, alkyl-C(O)NR13-, alkyl-OC(O)NR13- or alkylamino-C(O)NR13-; or R2 and R3 together are =O, =NOR10, =N- NR11R12 or =CH-alkyl; R8 is substituted phenyl, substituted heteroaryl, naphthyl, fluorenyl, diphenymethyl, alpha- substituted benzyl or alpha-substituted heteroarylmethyl; R9, R22 and R23 are as defined in the specification.
Patent NZ-529924-A (NZ)
Title: In vivo model system for an allergic condition that has been subjected to allergic sensitisation with an antigen that is not a helminth parasite
Inventor: MEEUSEN ELZA NICOLE THERESIA
IPC: A01K67/027
Filed: 2002-06-04
Abstract: Described are model systems for allergic conditions, and in particular to in vivo model systems in a large animal. The model systems described are especially useful for providing large numbers of activated or non-activated eosinophils, for the discovery and evaluation of anti-inflammatory drug targets and for providing a model for the in vivo study of asthma and the effects of allergy treatments. In a preferred embodiment the animal is a sheep. In one embodiment, repeated infusion of house dust mite allergen (HDM) into the mammary gland is used to induce a specific allergic response, which is characterised by the recruitment of inflammatory cells, particularly eosinophils, into the mammary lumen; these cells can be harvested from peripheral blood and mammary lavage (MAL). In a second embodiment, the mammal is immunised with soluble antigen, for example by repeated subcutaneous immunisation, and then subjected to a single challenge with the same antigen administered directly to the lung.
Patent NZ-532816-A (NZ)
Title: A2B adenosine receptor antagonists
Inventor: KALLA RAO
IPC: A61P11/06
Filed: 2002-11-08
Abstract: Disclosed are compounds of formula (I) and formula (II) that are A2B adenosine receptor antagonists, useful for treating various disease states, including asthma and diarrhea, wherein the substituents for the variables shown in formula (I) and formula (II) are as defined in the specification.
Patent NZ-540409-A (NZ)
Title: End portions for a flexible fluid containment vessel and a method of making the same
Inventor: EAGLES DANA
IPC: B63B25/08
Filed: 2002-04-05
Abstract: A flexible fluid containment vessel fabricated out of fabric for transporting and containing a large volume of fluid, particularly fresh water, having tapered front and/or rear portions formed out of the intermediate tubular structure, including a method of making the same. (62) Divided out of 528769
Patent NZ-541218-A (NZ)
Title: Thienopyrimidinediones and their use in modulation of autoimmune disease
Inventor: GUILE SIMON DAVID
IPC: A61P37/02
Filed: 2004-01-15
Abstract: Disclosed is a compound of formula (I), wherein the substituents are as defined in the specification. The compounds are inhibitors of T-cell proliferation and are useful in the modulation of autoimmune disease.
Patent NZ-543611-A (NZ)
Title: Arrangement for anchoring a floating structure
Inventor: HENRIKSEN SVEIN D
IPC: B63B21/50
Filed: 2004-05-18
Abstract: An arrangement for anchoring a floating structure comprising a mooring boom 650a, b pivotally arranged at either end, wherein each mooring boom at its free end has a bushing 654a, b through which anchor chains or wires can run. The anchor chain that runs through one of the bushings is fastened to the opposite end of the structure. In addition, for reasons of stability there may be tensioned lines which connect the free ends of both mooring booms to the structure.
Patent NZ-543926-A (NZ)
Title: Beverage additive mixture of trehalose and protein
Inventor: ZOERB HANS
IPC: A23L27/30
Filed: 2004-06-04
Abstract: Disclosed is an additive for a beverage. The additive comprises a mixture containing whey or casein proteins and trehalose. Also described is a method for simplifying the processing and storing the mixture in dehydrated form. The mixture is dehydrated, and then rehydrated before or during its addition to a beverage. The dehydration and subsequent rehydration permits processing, preserving, handling, and storing benefits-with substantially no damage to the protein or to the additive. Disclosed are the additive and beverages containing the additive. In addition provided are methods for preparing the additive and methods for preparing a flavoured beverage.
Patent NZ-544696-A (NZ)
Title: Composition for releasing rosiglitazone for an extended period of time
Inventor: HOKE JOHN FRANCIS
IPC: A61K9/20
Filed: 2004-08-06
Abstract: Disclosed is an oral dosage comprising an immediate release composition of 5-[4-[2-(N-methyl-N-(2 pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione or a pharmaceutically acceptable salt or solvate thereof, a modified release composition of the same compound, and an enteric composition with openings which expose the first two compositions to the environment of use.
Patent NZ-545536-A (NZ)
Title: TLR7 ligands for the treatment of hepatitis C
Inventor: AVERETT DEVRON R
IPC: A61K31/4745
Filed: 2004-09-01
Abstract: Disclosed is the use of a TLR7 ligand for the manufacture of a medicament for treating a hepatitis C virus infection in a patient, wherein the TLR7 ligand is selected from formulas 1a - 1h wherein the substituents are defined in the specification or a pharmaceutically acceptable salt, hydrate or stereoisomer thereof or a pharmaceutically acceptable salt or hydrate of said stereoisomer
Patent NZ-546042-A (NZ)
Title: Methods for improving growth and crop productivity of plants using an auxin and boron
Inventor: STOLLER JERRY H
IPC: A01N43/90
Filed: 2004-08-18
Abstract: Disclosed are methods for altering plant growth, e.g. limiting excessive growth, controlling internode length, controlling top growth, or controlling flower set, comprising: applying an aqueous solution of (a) an auxin selected from the group consisting of indole-3-acetic acid, indole-3-butyric acid and mixtures thereof at a rate of 0.0002 to 0.06 gram auxin per hectare per day and in an amount effective to alter growth, but wherein said amount is insufficient to negatively effect growth of said plant, together with (b) boron in an amount sufficient to extend the life of said auxin, said solution comprising 0.001 to 10.0 percent-by-weight boron in a form selected from the group consisting of boron, boron-containing compounds and mixtures thereof.
Patent NZ-547302-A (NZ)
Title: Apparatus and methods for assessing metabolic substrate utilization
Inventor: POLIDORI DAVID
IPC: G06F19/00
Filed: 2004-11-19
Abstract: A processor-readable medium includes code to receive data indicative of a plasma glucose concentration, a plasma free fatty acid concentration, and a respiratory quotient of a subject. The processor-readable medium also includes code to calculate, based on the data, respective values of a set of metabolic parameters. The set of metabolic parameters includes a first metabolic parameter and a second metabolic parameter. The value of the first metabolic parameter is indicative of whether the subject has a predisposition towards oxidation of a first type of metabolic substrate or a second type of metabolic substrate, and the value of the second metabolic parameter is indicative of the subject's responsiveness to a change in availability of the first type of metabolic substrate or the second type of metabolic substrate. Methods for assessing metabolic substrate utilization are also described.
Patent NZ-551960-A (NZ)
Title: Nozzle protector cap
Inventor: MORGAN STUART
IPC: B05B15/50
Filed: 2005-05-20
Abstract: A blow off cap and nozzle 10 for use in fire suppression systems includes a nozzle 30 with a tip having an aperture 16 through the tip and a cap formed from a sealing membrane 20 attached to the nozzle by a retainer 40 which retains and seals the membrane to the nozzle tip. The membrane 20 in conjunction with a plug 50 prevents entry of contaminants into the nozzle and dripping from the nozzle but the membrane is perforated and the plug is ejected once mains pressure is applied to the pipe to which the nozzle is connected so that the nozzle sprays water in the usual way.
Patent NZ-554388-A (NZ)
Title: VLP-Antigen conjugates and their uses as vaccines
Inventor: BACHMANN MARTIN
IPC: A61K39/00
Filed: 2005-10-05
Abstract: Disclosed is a composition comprising: (a) a virus-like particle (VLP) comprising coat proteins, mutants or fragments thereof, of an RNA-bacteriophage with at least one first attachment site, wherein said VLP is recombinantly produced by a host, and said VLP is essentially free of host RNA, and wherein said mutant or said fragment of said coat protein of said RNA-bacteriophage is capable of assembling into a VLP, and wherein said mutant of said coat protein of said RNA-bacteriophage has an amino acid sequence identity of at least 80% with the amino acid sequence of said coat protein, and wherein said fragment of said coat protein of said RNA-bacteriophage is a polypeptide of at least 70% of the length of said coat protein (b) at least one antigen with at least one second attachment site; wherein said at least one antigen (b) is linked to said VLP (a) through said at least one first attachment site and said at least one second attachment site, and wherein said composition further comprises at least one polyanionic macromolecule packaged inside said VLP, and wherein said polyanionic macromolecule is selected from the group consisting of: (a) polyanionic polypeptides; (b) polyanionic saccharides; (c) polyanionic organic polymers; and (d) nucleic acids, wherein said nucleic acid is not a toll-like receptor ligand.
Patent NZ-561322-A (NZ)
Title: Parallel indentification of antibacterial targets and inhibitors
Inventor: SCHMIDT FRANCIS J
IPC: C40B40/02
Filed: 2006-02-10
Abstract: Disclosed is a method for the parallel identification of (1) an antibacterial compound from an extract comprising a complex mixture of compounds one or more of which shows antibacterial activity and (2) a gene that encodes a protein essential for cell viability or required for cell infectivity that is a target for that antibacterial compound, the method comprising contacting bacterial cells comprising a genomic library with the extract on a plating medium and identifying cells that are resistant or sensitive to the extract, selecting cells that are resistant to the extract and identifying the target gene that confers resistance to the extract and, in parallel, guiding fractionation of the extract by exposing the sensitive and resistant cells to the various fractions, and thereby identifying the antibacterial compound in the extract.
Patent NZ-562413-A (NZ)
Title: Headgear assembly for nasal pillows mask
Inventor: GUNARATNAM MICHAEL KASSIPILLAI
IPC: A61M16/08
Filed: 2004-02-20
Abstract: A headgear assembly for securing a nozzle arrangement of a nasal pillows mask including a base portion and a pair of nasal pillows projecting from the base portion in a desired adjusted position on the face of a patient's head, includes a rear portion 599 formed from a soft and flexible strap material and including an adjustable top strap arrangement structured to pass over a top portion of the patient's head and a rear strap arrangement structured to pass over a rear portion of the patient's head, and a pair of side portions, each side portion 580, 592 being structured to extend from the rear portion towards the nozzle assembly. The adjustable top strap arrangement includes first and second top strap portions 598 structured to pass over the top of the patient's head and a top strap buckle arrangement 570 adjustably coupling together the top strap portions, the top strap buckle arrangement being structured to allow symmetrical adjustment of the headgear assembly, by allowing the tension in the first and second top strap portions to be symmetrically altered, the top strap buckle arrangement being configured to be centrally located on the head of the patient.
Patent NZ-563332-A (NZ)
Title: Wall assembly using corrugated panels snapped in place to a supporting rail on the floor or ceiling by a plug
Inventor: PERRIN JONATHON GILBERT FRANCIS
IPC: E04B1/66
Filed: 2006-05-22
Abstract: A securing cap (43) used in the wall (40) of a building is disclosed. The cap (43) fills the gap in a single space formed between two adjacent corrugations (44) in the wall (40) and a floor or ceiling mounting (42). The cap (43) has a cover portion and one or more legs extending downwardly from the cover portion. The cap also has one or more protrusions to engage with the corrugated wall (40) and the floor or ceiling mounting (42). The protrusions snap fit into openings in the wall (40) and engage a lip on the floor or ceiling mounting (42) to enclose the single space and facilitate fixing of the wall (40) to the floor or ceiling mounting (42).
Patent NZ-563652-A (NZ)
Title: A padlock having a removable shackle when the retaining means is not accessible when the padlock is closed
Inventor: TONG H W
IPC: E05B67/06
Filed: 2006-08-17
Abstract: A padlock with a removable shackle is disclosed. The present invention discloses a padlock having a body (12), a shackle (14) and a shackle retaining element. The padlock has an unlocked condition wherein the padlock is said to be open and the locked condition wherein it is said to be locked. The shackle (14) has leg members (16 and 18) and the body (12) has an aperture (20 and 22) for accommodating each leg member (16 and 18). Additionally, the body has an opening which communicates between one leg member of the shackle and an exterior of the body (12). The shackle retaining element is accessible through the opening when the padlock is open. The one leg member has an aperture for receiving the shackle retaining element in a selectively protrudable manner. When the shackle retaining element protrudes from the aperture of the one leg member, the shackle (14) cannot be entirely removed from the body (12) whereas, when the shackle retaining element does not protrude from the one leg member and the padlock is open, the shackle (14) can be entirely removed from the body (12).
Patent NZ-564847-A (NZ)
Title: Method for detection of microorganism and kit for detection of microorganism
Inventor: YOSHIDA SHINICHI
IPC: C12N15/09
Filed: 2006-02-17
Abstract: Provided is a method for detecting live cells by distinguishing live uninjured cells from dead cells and injured cells of a microorganism in a test sample, which comprises the following steps: a) the step of treating the test sample with a topoisomerase poison and/or a DNA gyrase poison, b) the step of extracting DNA from the test sample, and amplifying a target region of the extracted DNA by PCR wherein the length of the target region is 100 to 3000 nucleotides, and c) the step of analyzing an amplification product.
Patent NZ-565494-A (NZ)
Title: Xanthine derivatives as selective HM74A agonists
Inventor: HATLEY RICHARD JONATHAN DANIEL
IPC: A61K31/495
Filed: 2006-08-08
Abstract: Disclosed is a xanthine derivative of formula (I), or a salt thereof, there R1 is -(alkylene)m-X-(alkylene)n-Y, X is heteroaryl or heterocyclyl, Y is aryl, heteroaryl, and O-aryl, and wherein the other variables and substituents are as defined in the specification. Also described is the use of the compound to treat diabetic dyslipidaemia, mixed dyslipidaemia, hyperlipoproteinaemia, inflammatory diseases or conditions, heart failure, hypercholesteraemia, cardiovascular disease atherosclerosis, arteriosclerosis, hypertriglyceridaemia, type II diabetes mellitus, type I diabetes, insulin resistance, hyperlipidaemia, anorexia nervosa, obesity, coronary artery disease, thrombosis, angina, chronic renal failure, peripheral vascular disease or stroke.
Patent NZ-567331-A (NZ)
Title: Load support mountable body for helicopters
Inventor: MACKINNON GRANT
IPC: B64C1/20
Filed: 2006-09-12
Abstract: A mounting body for attachment to a floor of a helicopter, where the mounting body is oriented transversely to a longitudinal axis of the helicopter and extends between opposed doorways of the helicopter, is disclosed. The mounting body has securing members on each side which extend outwardly therefrom in plan view. The mounting points are to be secured to securing locations in the floor of the cabin which are helicopter "hard points" or certified securing points set by authorities for supporting loads or safety apparatus. Each of the securing points are located externally of each of the opposed sides of the mounting body and spaced therefrom. The mounting body has releasable attachment means for attachment to a counterweight locatable at one end of the mounting body or to a support platform locatable at another end of the mounting body,
Patent NZ-568577-A (NZ)
Title: Chimeric, hybrid and tandem polypeptides of nisserial meningococcal NMB1870
Inventor: MASIGNANI VEGA
IPC: C07K14/22
Filed: 2006-11-27
Abstract: A Neisseria meningitidis polypeptide NMB1870 that has at least 85% identity to SEQ ID NO: 57. The polypeptide also has at least one of the following residues substituted or deleted: T16, Q18, Q20, D21, S22, E23, H24, S25, G26, K27, Q33, R35, I36, G37, I39, K48, E51, G52, R54, T56, A67, K70, A78, A79, K85, D97, P105, S114, S116, L118, N120, Q121, A122, T147, N149, G150, I151, R152 or H153. The polypeptide can be used in an immunogenic composition to prevent or treat infection caused by N. meningitidis serogroup B in any of the families I, II or III.
Patent NZ-573375-A (NZ)
Title: Visceral fat accumulation inhibitor, and agent for promoting the increase in and/or inhibiting the decrease in blood adiponectin level
Inventor: KAWAKAMI HIROSHI
IPC: A23L2/52
Filed: 2007-05-30
Abstract: Disclosed is the use of a milk fat globule component in the manufacture of a medicament for treating metabolic syndrome.
Patent NZ-574851-A (NZ)
Title: Improved boom arrangement
Inventor: WEBB DANIEL
IPC: E02F3/42
Filed: 2007-07-17
Abstract: A lift assembly 10 for a front end loader bucket or similar implement includes a boom arm 46 and a linkage system for tilting the bucket (mountable on bracket 70) relative to the loader vehicle (connected to bracket 14). The linkage system includes a crank such as a bell crank 80, a top link 32 and an implement-side link 78,84. The top link 32 is substantially housed and concealed within the boom arm and is pivotally mounted to the crank 80 at a location 106 that falls between a pivot 102 which pivotally mounts the crank to the boom arm and a pivot 82 which pivotally mounts the implement-side link to the crank.
Patent NZ-576834-A (NZ)
Title: A connector for a tank that is fastened using a graity bias toggle against the inside wall of the tank
Inventor: MAROTTA PETER
IPC: F16L19/06
Filed: 2009-05-08
Abstract: A tank connector (1) for mounting in a hole in a wall of a tank (3) is disclosed. The connector (1) includes a main body and a securing assembly for securing the main body to the tank (3). The securing assembly in made up of a fastener (8) and a retaining member (15). The retaining member (15) has at least one pivotally mounted abutment member for abutting with an interior wall surface of the tank (3). To fit the connector (1), the retaining member (15) is inserted through an aperture in the tank (3). The retaining member (15) then pivots though gravity into a position in which it can be moved into abutment with the interior wall surface of the tank (3). As the fastener (8) is tightened the retaining member (15) is drawn towards the tank wall (3), trapping the tank wall (3) in between the retaining member (15) and the main body of the connector.
Patent NZ-581097-A (NZ)
Title: Amino acid sequences directed against rank-l and polypeptides comprising the same for the treatment of bone diseases and disorders
Inventor: BEIRNAERT ELS
IPC: C07K16/22
Filed: 2008-05-23
Abstract: Disclosed are amino acid sequences that are directed against RANK-L, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides; to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes.
Patent NZ-585830-A (NZ)
Title: Electric fence tester and method of testing an electric fence
Inventor: WOODHEAD ROBERT CHARLES BRYAN
IPC: G01R31/02
Filed: 2010-06-01
Abstract: 585830 Disclosed is an electric fence tester. The tester includes a line probe (1) for forming an electrical connection with an electric fence (2) and a ground probe (6) for forming an electrical ground connection in soil. An ammeter (4) in series with impedance (5) is electrically connected between the line probe (1) and the ground probe (6). The ammeter (4) is suitable for measuring pulse currents within the electric fense.
Patent NZ-587598-A (NZ)
Title: Methods of increasing proliferation of a cell by administering a low magnitude, high frequency mechanical signal
Inventor: RUBIN CLINTON
IPC: C12N5/0775
Filed: 2009-03-02
Abstract: Disclosed is a method of increasing the proliferation of a cell, the method comprising administering to the cell in vitro a mechanical signal on a periodic basis and for a time sufficient to enhance or increase the proliferation of the cell to an extent greater than would be expected in the absence of the mechanical signal, wherein the frequency of the mechanical signal is 5-1000 Hz and the magnitude of the mechanical signal causes the cell to accelerate at a particular acceleration rate, with the proviso that human totipotent cells are excluded. Also disclosed is the use of a cell that has been treated according to the method in the manufacture of a medicament for treating a patient, wherein the cell is not a human totipotent cell.
Patent NZ-591430-A (NZ)
Title: Apparatus with flexibly mounted spud carriage through tensioned spring and hydraulic arrangement to limit rotation on the horizontal axis for a dredging vessel
Inventor: CLYMANS ETIENNE
IPC: E02F3/04
Filed: 2006-06-02
Abstract: Apparatus for accommodating a substantially vertical spud (3) of a dredging vessel with a longitudinal direction is disclosed. The apparatus comprises a spud carriage (6) which is mounted for limited rotation around a horizontal transverse axis, wherein-at least a first and a second spring means (Fig. 3) is arranged under bias between vessel and spud in the longitudinal direction for the purpose of absorbing a moment (M) on the spud carriage. First and second spring means compensate each other in the non-loaded situation of the spud. At least one spring means is provided with a spring force limiting means for limiting the tension in the spring element from a determined maximum moment on the spud carriage. First and second spring devices are connected respectively via a first and second hydraulic cylinder (95) to the vessel.