baber/WOPTO huggingface dataset:
Patent IL-146916-A0 (IL)
Title: Nitrobenzene and aminobenzene derivatives and a process utilizing the same
IPC: C07D417/12
Filed: 2000-06-27
Abstract: This invention provides a process for the preparation of a benzimidazole derivative (9) or a pharmaceutically acceptable salt thereof, by condensation of a compound of formula (6) with a compound of formula (7) in the presence of a condensing agent to afford a compound of formula (8), followed by, if necessary removal of the amino protecting group of compound (8), and then cyclization of compound (8) in the presence of an acid, <CHEM> wherein R<1e>, R<2e>, R<3e> and R<4e> are each independently hydrogen, hydroxyl, alkyl, alkoxy, benzyloxy, acetoxy, trifluoromethyl or halogen, R<7e> is alkyl and R<8e> is hydrogen or an amino protecting group, <CHEM> wherein R<1e>, R<2e>, R<3e>, R<4e>, R<7e> and R<8e> are as defined above, <CHEM> wherein R<1e>, R<2e>, R<3e>, R<4e>, and R<7e> are as defined above.
Patent IL-147184-A0 (IL)
Title: Substituted benzimidazole
IPC: A61K31/44
Filed: 2000-06-09
Abstract: Compounds of formula Iare suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of NFkappaB is involved.
Patent IL-156774-A0 (IL)
Title: Inhibitors of cruzipain and other cysteine proteases
IPC: A61K31/407
Filed: 2002-01-17
Abstract: Compounds of general formula (I) or general formula (II):- wherein R1, P1, P2, Q, Y, (X)o, (W)n, (V)m, Z and U are as defined in the specification, are inhibitors of cruzipain and other cysteine protease inhibitors and are useful as therapeutic agents, for example in Chagas' disease, or for validating therapeutic target compounds.
Patent IL-157179-A0 (IL)
Title: Fused heterocyclic compounds
IPC: C07D217/24
Filed: 2002-02-01
Abstract: The present invention provides a compound of the formula: wherein ring A is an optionally substituted 5 to 10-membered aromatic ring; R<SUP>1 </SUP>and R<SUP>2 </SUP>are the same or different and each is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is a bond and the like; and L is a divalent hydrocarbon group, and a salt thereof, except 3-(aminomethyl)-2,6,7-trimethyl-4-phenyl-1(2H)-isoquinolinone, 3-(aminomethyl)-2-methyl-4-phenyl-1(2H)-isoquinolinone, 3-(aminomethyl)-6-chloro-2-methyl-4-phenyl-1(2H)-isoquinolinone and 3-(aminomethyl)-2-isopropyl-4-phenyl-1(2H)-isoquinolinone. The compound shows a superior peptidase-inhibitory activity and is useful as an agent for the prophylaxis or treatment of diabetes and the like.
Patent IL-162142-A0 (IL)
Title: A system for sealing the secondary flow at the inlet to a nozzle of a turbomachine having post-combustion chamber
IPC: F02C7/24
Filed: 2004-05-24
Abstract: An aviation turbomachine comprising, downstream from the turbine, a post-combustion chamber extended by at least one nozzle, said chamber being defined radially by a thermal protection lining dispsoed inside a casing, said casing and said lining together defining an annular channel in which, in operation, there flows a secondary flow, an annular diaphragm secured to said casing being disposed at the downstream end of said channel, said nozzle comprising a plurality of flaps hinged to the upstream end of said casing, each flap being fitted on its inside face with a thermal protection plate co-operating with said flap to define a passage for being fed with cooling air delivered by said diaphragm, wherein the feed of cooling air to said passages is provided by an annular duct defined on the outside by a first flexible annular gasket retained, in operation, pressed in sliding contact against the downstream inside face of the casing and against the upstream inside faces of the flaps under urging from the pressure of the secondary flow, and defined on the inside by a second flexible annular gasket whose upstream end is fixed to the radially inner zone of the diaphragm, and whose downstream end is pressed in sliding contact against the upstream inside face of the protection plates.
Patent IL-164459-A0 (IL)
Title: Apparatus and method to generate and control optical traps to manipulate small particles
IPC: B01J19/12
Filed: 2003-04-10
Abstract: The present invention relates generally to an apparatus and method to generate and control optical traps ( 1000, 1002 ) for manipulation of small particles. An upstream modification of an input laser beam ( 12, 22 ) provides a beam with a square or other preselected, cross section of intensity which can be used to form optical traps ( 1000, 1002 ) with a corresponding cross section of intensity.
Patent IL-166357-A0 (IL)
Title: An apparatus for dispensing pills
IPC: B65D47/20
Filed: 1999-08-16
Abstract: In a pocket dispenser (1) for dispensing pills from a blister pack (2) to be placed in a ring shape, cavities (3) containing pills (P) are so distributed that the openings of the cavities therein are directed outwardly. The dispenser comprises a first part (5) for receiving the blister pack (2) in a ring shape, and a second part (6) fitting on said first part (5), which envelops the blister pack (2) together with the first part (5). The first part (5) and/or second part (6) comprise(s) at least one passage opening (7) with which a pill (P) to be dispensed can be aligned. A push-out means (8) includes an operating element (9), which can be positioned in line with the respective pills in the blister pack and with the passage opening (7) and which can be operated by said operating element (9) to move in at least substantially radial direction for pushing out the pill (P) to be dispensed through the passage opening (7). The operating element (9) is in the form of a pivoted push button, which is drivingly connected to the push-out means (8) which is slidably accommodated in a guide. The part (5) of the dispenser (1) that supports the operating element (9) includes means (20, 29) for imposing the pivoting movement. The push-out means (8) includes an ejector nose (32) having a sloping ejection surface (33), such that each cavity (3) is loaded off-center upon ejection of a pill (P). The blister pack (2) comprises means which are visible through said passage opening (7) for providing an indication as to the contents of the cavity in the blister pack that is positioned in line with the passage opening (7).
Patent IL-185361-A0 (IL)
Title: Switch matrix system with plural bus arbitrations per cycle via higher-frequency arbiter
Filed: 2007-08-19
Abstract: An arbiter in a bus system arbitrates multiple bus transaction requests in a single bus frequency clock cycle, by operating at a frequency greater than the bus frequency. This allows for two or more arbitration operations in a single bus frequency clock cycle with one instance of arbitration logic. The arbiter may arbitrate for two or more slave devices, or may arbitrate multiple master device requests directed to the same slave device. The arbiter frequency may be variable, and may be predicted based on, e.g., prior bus activity. If only one bus transaction request is pending, the arbiter frequency may equal the bus frequency. The results of an earlier arbitration decision may be utilized to more intelligently make subsequent arbitration decisions in the same bus frequency clock cycle.
Patent IL-205696-A0 (IL)
Title: Heterocyclic derivatives, compositions comprising the same and uses thereof
Filed: 2010-05-11
Abstract: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Patent RO-130700-A0 (RO)
Title: Boiler having solid and gaseous fuel supplied firing chamber
Inventor: INVENTATORI NEDECLARAŢI
IPC: F24H1/22
Filed: 2015-06-04
Abstract: The invention relates to a boiler having the firing chamber supply based on solid and gaseous fuel. According to the invention, the boiler consists of a sheet-metal protecting jacket (7) over which a layer of mineral wool is placed, the noxious substances and gases resulted after burning are discharged by means of a smoke flue (2) which has a regulation valve (19) for regulating the air flow towards the exterior, the draft regulation being performed by means of the valve placed in a connection (3), which makes a direct connection with the boiler inside, being in direct contact with the heating medium, this allowing the direct mechanical control of a regulation valve (8), by means of a mechanical connection, the boiler supply with various fuels being performed by means of a gate (4) which may be changed depending on the type of fuel, and the residues resulting after burning in a firing place (21) may be discharged by using a gate (5), where, in order to prevent a direct contact between the boiler and the ground, the boiler is mounted on a metallic platform (6), and the protection against overheating is carried out by means of a coil (9) placed at the upper part of the space between the boiler walls, to which the boiler protecting thermal valve may be connected, the boiler turn line is represented by a connection (1), this being the boiler heating medium exit place, and the inlet is made through a return line (10), the boiler emptying being performed by a connection (11) placed at the lower part of the boiler, and the residues resulting after burning being collected in an ash-pan (12); the heating medium has a direct circuit under the firing place, through a series of pipes (13), covered by a metallic grate, and the heating medium circuit has, in its turn, three zones (14, 16 and 17) inside the boiler through which the heat exchange is carried out, their order depending on the temperatures of the burnt gases passing through them.
Patent IE-20020409-A1 (IE)
Title: Use of sertraline to treat social phobia
Inventor: HACKETT ELIZABETH
IPC: A61P25/20
Filed: 1990-11-01
Abstract: The use of the compound (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine or a pharmaceutically acceptable salt thereof for the manufacture of a medicament to treat or prevent social phobia and the symptoms associated with such a disorder.
Patent LU-87162-A1 (LU)
Inventor: BURGHARDT HARTMUT DR
IPC: G02F1/29
Filed: 1988-03-16
Abstract: A bidirectional light waveguide communication system that has a light source preferably formed by a laser at one end of the light waveguide and a reflex transmitter at the other end of the waveguide with the reflex transmitter formed by a halved controllable optical directional coupler which has two strip waveguides that are terminated by a partially reflecting mirror and which has control electrodes which receive a transmission signal. An opto-electrical transducer receives the received light signal from both strip waveguides after the partially reflecting mirror.
Patent MA-18812-A1 (MA)
Inventor: BERNARD MARTINOT
IPC: C08F2/34
Filed: 1980-04-18
Abstract: An apparatus for evacuating the gases resulting from the decomposition of industrial process gases, such as ethylene, contained in a vessel under high pressure is adjacent to the vessel. The apparatus comprises: (1) at least one safety means separating the apparatus from the vessel; (2) a reservoir with a volume which is 2 to 100 times that of the vessel; (3) at least one connecting pipe between the vessel and the reservoir; and (4) at least one chimney between the reservoir and the atmosphere. The apparatus is useful for the recovery of decomposition gases for the purpose of preventing atmospheric pollution. The risk of explosion is reduced by evacuating decomposition gases through the apparatus.
Patent MA-19638-A1 (MA)
IPC: C07D501/36
Filed: 1982-11-03
Abstract: A crystalline water soluble disodium salt of 7- beta -[2-(2-aminothiazol-4-yl)-2-syn-methoximinoacetamido]-3-(5-carboxymeth yl-4-methyl-1,3-thiazol-2-ylthiomethyl)ceph-3-em-4-carboxylic acid (cefodizim), or an adduct or solvate thereof with water and/or an organic solvent.
Patent MA-19764-A1 (MA)
IPC: A61K31/435
Filed: 1983-03-31
Abstract: Salicylic acid derivatives of the formula I   <IMAGE>   wherein R1, W, X, Y and Z have the meanings indicated or a physiologically tolerated salt thereof, processes for their preparation, pharmaceutical formulations based on these compounds and their use as antidiabetic agents.
Patent MA-27093-A1 (MA)
Title: Derives de sulfonamides, leur preparation et leur application comme medicaments.
Inventor: MARCE-VIDAL RAMON
IPC: C07D409/12
Filed: 2004-06-07
Abstract: DERIVES DE SULFONAMIDES, LEUR PREPARATION ET LEUR APPLICATION COMME MEDICAMENTS La présente invention concerne de nouveaux dérivés de sulfonamides, de formule générale (I), ainsi que leurs sels physiologiquement acceptables, les procédés pour leur préparation, leur application comme médicaments en thérapeutique humaine et/ou vétérinaire et les compositions pharmaceutiques qui les contiennent.
Patent MA-28190-A1 (MA)
Title: Centrale  de broyage et de filtration du soja  pour fabrication de pollen de substitution
Inventor: MARIGOT ROBERT
Filed: 2005-03-15
Abstract: CENTRALE DE BROYAGE ET DE FILTRATION DU SOJA POUR FABRICATION DE POLLEN DE SUBSTITUTION Dispositif mécanique de broyage et de filtration par aspiration de l'air permettant une micronisation du soja à 800 u. La poussière de soja en suspension est compressée dans des sacs spéciaux à maille inférieure à 800 u. Le produit final est de granulométrie assimilable par l'abeille.
Patent MA-27412-A1 (MA)
Title: Nouveaux pyrimidine-4,6-dicarboxamides pour l'inhibition selective de collagenases
Inventor: KLINGLER OTMAR
IPC: A61P19/00
Filed: 2005-04-29
Abstract: L'invention concerne de nouveaux diamides d'acide pyrimidine-4,6-dicarboxylique correspondant à la formule (I), lesquels peuvent être utilisés pour l'inhibition sélective de la collagénase (MMP 13). Ces composés peuvent donc être utilisés pour le traitement de maladies dégénératives des articulations.
Patent MA-38532-A1 (MA)
Title: Suivi et controle des performances de vente d'une entreprise pharmaceutique
Inventor: CHAROUB ABDELLAH
IPC: G06Q30/00
Filed: 2015-10-21
Abstract: Un système informatique de suivi et de control des performances de vente d'une entreprise pharmaceutique composé de modules distribués. Certains modules sont installés sous forme d'applications mobiles natives sur des appareils mobiles et pouvant fonctionner en mode hors ligne. D'autres modules sont installés au niveau de serveurs et accessibles depuis des interfaces web à accès restreint.
Patent MA-38928-A1 (MA)
Title: Protéines de liaison à l'antigène gitr pour son utilisation dans le traitement du cancer
Inventor: FOLTZ IAN
IPC: A61K39/395
Filed: 2016-03-25
Abstract: L'invention concerne des protéines de liaison à l'antigène qui activent gitr. Des acides nucléiques codant pour ces protéines de liaison à l'antigène et des vecteurs et des cellules contenant lesdits acides nucléiques sont en outre décrits. Les protéines de liaison à l'antigène selon l'invention sont des protéines de valeur dans les méthodes thérapeutiques dans lesquelles il est utile de stimuler la signalisation gitr, pour induire ou améliorer ainsi une réponse immunitaire chez un sujet. Par conséquent, ces protéines de liaison à l'antigène ont une utilité dans divers traitements immunothérapiques, comprenant le traitement de divers cancers et infections.
Patent MA-39575-A1 (MA)
Title: Antenne micro cellulaire intelligente dans les bandes gsm 3g et 4g pour lutter contre la tricherie par téléphonie mobile aux centres des examens
Inventor: ER REGUIG Zakaria
IPC: H01Q1/38
Filed: 2016-12-26
Abstract: La présente invention concerne un réseau d'antenne microcellulaire intelligente à cinq patchs en technologie microruban miniature, couvrant les bandes de fréquences gsm 3g et 4g. La modélisation et la simulation du modèle de base sont effectuées avec la méthode des éléments finis. Cette étude nous permettra de déterminer le coefficient de réflexion, le taux d'onde stationnaire, le gain, la bande passante èt le rayonnement directionnel. Notre idée originale consiste à concevoir un nouveau dispositif anti-triche par téléphonie mobile en prenant l'avantage du fait que les mobiles scrutent la bande gsm 3g et 4g. Avec la solution proposée, nous pouvons utiliser une station de base miniaturisée en mouvement sur un drone qui se déplace de manière autonome à l'intérieur des salles d'examen pour détecter les téléphones portables en communication. Ceci va résoudre la grande préoccupation des enseignants et des responsables du système éducatif à l'échelle nationale. Dans cet objectif, une nouvelle antenne réseau microcellulaire intelligente en technologie microruban miniaturisée installée dans un drone en mouvement automatique destinée à l'application anti-triche dans les salles d'examen. Ce qui permettra d'améliorer les conditions d'examen à l'échelle nationale. Le dispositif selon l'invention est un réseau d'antenne intelligent en technologie microruban 3g, 4g et wimax adapté aux applications anti-triches par téléphonie mobile aux centres des examens.
Patent UY-23643-A1 (UY)
Title: Perfeccionamiento del proceso para mejorar el vacio en el interior de ampollas de vidrio para botellas termicas
Inventor: SOBRAL JOAO FERNANDO
IPC: F17C13/00
Filed: 1993-09-07
Abstract: Según la presente invención, en el espacio (1) existente entre las paredes dobles (2) y (2') de la ampolla de vidrio (3), y después de su azogamiento y secado, se introducen uno o mas "getters" (4) a través de un tubo (5), despues de lo cual, en caso de que la ampolla se efectúe por debajo y el tubo (5) esté colocado en la parte inferior central de la ampolla, se introduce una pieza (6) en dicho tubo, que se aloja en la abertura inferior (7) de la pared externa (2) configurando una barrera o filtro que impide la salida de los "getters" (4) del espacio (1), y que está dotada de aberturas (6A) así como patas inferiores (6B) y superiores (6C), con un efecto de muelle; la pieza (6) no es necesaria si el bombeo es efectuado por encima o por el costado, ni tampoco si el propio "getter" tiene en su composición elementos físicos, químicos o mecánicos que hacen que el mismo me dilate o expanda a dimensiones mayores que el diámetro interno del tubo (5); la pieza (6) tampoco es necesaria si, después de la introducción del "getter" por el tubo, éste sufre un estrechamiento de su diámetro por medio del ablandamiento y estiramiento del vidrio. La figura 1 es un corte longitudinal esquemático de una ampolla de vidrio en la que se ha introducido el presente perfeccionamiento.
Patent UY-23876-A1 (UY)
Title: Pelicula / tela tejida permeable al aire, similar a genero
Inventor: MCCORMACK ANN LOUISE
IPC: A61L15/00
Filed: 1994-12-19
Abstract: Se describe en la presente una película respirable o que respira y un compuesto de película / tela no tejida respirable, similar a género, hecho de la película respirable que es adelgazada por estiramiento y está unida o adherida a una tela no tejida fibrosa de poliolefina. Ciertas películas termoplásticas de polietileno lineal de baja densidad son difíciles de unir térmicamente a telas no tejidas de polipropileno, debido a la incompatibilidad de los polímeros. La presente invención incorpora un agente de unión o ligado en una o en ambas de las dos capas, facilitando así la unión térmica de las dos capas. También se describen procedimientos para formar los diversos compuestos.
Patent UY-24254-A1 (UY)
Title: Metodo de produccion de revestimiento en sustrato de madera reconstituida
Inventor: HSU OSCAR HSIEN-HSIANG
IPC: B05D7/24
Filed: 1996-06-07
Abstract: La presente invención esta dirigida a producir un revestimiento duro y suave en sustrato de madera. Una capa de emulsión de látex polimerizada se aplica en la superficie del sustrato de madera, tales como la tabla de filamento orientado. La capa se seca, comprime y luego se cura para formar una capa. Si se desea, la capa curada puede proveerse con un tratamiento de calor de poscuración para mejorar su dureza. La invención esta dirigida también a aplicar y secar la capa de una emulsión de látex polimerizada en una estera de fibras o virutas de madera y luego a comprimir y curar la capa comprimida y la estera en el tablón duro que posee un revestimiento duro y suave. El revestimiento de la presente invención es útil como capa de sellador en un sustrato de madera. Al agregar un pigmento a la emulsión polimerizada, la capa de sellador puede utilizarse para proveer una capa de terminación en el sustrato de madera.
Patent UY-24387-A1 (UY)
Title: Dihidrato del (2r,3s)-3-ter-butoxicarbonilamino-2-hidroxi-3-fenilpropionato de 4,10beta-diacetoxi-2alfa-benzoiloxi-5beta, 20-epoxi-1-hidroxi-9-oxo-19-norciclopro-pa(g)tax-11-eno-13-alfa-ilo y su procedimiento de preparación.
IPC: A61K31/335
Filed: 1996-12-02
Abstract: Nuevo compuesto caracterizado porque es el dihidrato de (2R,3S)-3-ter-butoxicarbonilamino-2-hidroxi-3-fenilpropionato de 4,10beta-diacetoxi-2alfa-benzoiloxi-5beta, 20-epoxi-1-hidroxi-9-oxo-19-norciclopropa(g)tax-11-eno-13alfa-ilo; que presenta propiedades anticancerosas y antileucémicas.
Patent UY-25040-A1 (UY)
Title: Derivados de 9-desoxo-9a-aza-9a-homoeritromicina a c-4' sustituidos
Inventor: GLAZER EDWARD ALAN
IPC: A61K31/70
Filed: 1998-06-11
Abstract: Esta invención se refiere a derivados de 9-desoxo-9a-aza-9a-homoeritromicina A C-4" sustituidos, compuestos de fórmula (I) y a sales farmacéuticamente aceptables de los mismos. Tales antibióticos macrólidos incluyen varios derivados de la eritromicina A como la azitromicina. Los compuestos de fórmula (I) son agentes antibacterianos que pueden usarse para tratar diversas infecciones bacterianas y protozoarias. La invención también se refiere a composiciones farmacéuticas que los contienen y a procedimientos para tratar las infecciones bacterianas y protozoarias mediante la administración los mismos. La invención también se refiere a procedimientos y a los intermedios útiles para dicha preparación. Compuestos de fórmula (I), en la que: R1 es H, hidroxi o metoxi; R2 es hidroxi; R3 es alquilo, alquenilo, alquinilo, ciano, CH2S(O)nR8, en el que n es un número entero entre 0 y 2, CH2OR8, CH2N(OR9)R8, CH2NR8R15, (CH2)m-arilo, ó (CH2)m-heteroarilo, en el que m es un número entero entre 0 y 4 y en los que los anteriores grupos R3 están opcionalmente sustituidos en 1 a 3 grupos R16; ó R2 y R3 están unidos formando un anillo oxazolilo; R4 es H, C(O)R9, C(O)OR9, C(O)NR9R10 ó un grupo protector de hidroxi. Útiles para trastornos relacionados con dichas infecciones que incluyen: neumonía, otitis media, sinusitis, bronquitis, tonsilitis y mastoiditis; faringitis, fiebre reumática y glomerulonefritis; infecciones del tracto respiratorio; infecciones de la piel y del tejido blando, abscesos y osteomielitis y fiebre puerperal; infecciones del tracto urinario agudas sin complicaciones; uretritis y cervicitis, y enfermedades de trasmisión sexual, entre otras.