Patent GB-1391801-A (GB)
Title: Compositions based on derivatives or homologues of cysteamine  for counteracting the greasy appearance of the head of hair and  of the skin
IPC: C07D213/70
Filed: 1972-04-21
Abstract: 1391801 Cosmetic compositions L'OREAL 21 April 1972 [23 April 1971] 18605/72 Heading A5B A composition, suitable for application to the head of hair and/or the skin, contains in an appropriate vehicle for said application, at least one active compound (or a salt thereof) corresponding to the following formula: in which: 1) n is 0; in which case, R 1  and R 2  each independently represents a hydrogen atom or CH 3  or n is 1; in which case, R 1  and R 2  each represents a hydrogen atom, 2) A is chosen: Either from the group of meanings (a), in which A represents a hydrogen atom, a nicotinoyl radical, a radical of the formula -COR 3  or -SO 2 R 3 , in which: R 3  represents an alkyl radical with 1 to 6 carbon atoms or a radical of the formula: in which R, represents a hydrogen, a methyl radical, an acetamido radical or an alkoxy radical with 1 to 4 carbon atoms, or from the group of meanings (b) in which A represents -CONH 2 , a glutamyl radical, a picolinoyl radical, an isonicotinoyl radical or a radical of the formula -COR 5  or -SO 2 R' 5  in which: R 5  represents H, an alkyl radical with 7 to 18 carbon atoms, an alkenyl radical with 2 to 18 carbon atoms, a -CH 2 Cl radical, a -CF 3  radical, a group of the formula: a group of the formula: a -CH 2 -CH 2 -COOH radical, a radical of the formula: or its N-oxide derivative, a radical of the formula: a radical of the formula V: wherein R 6  represents an alkyl radical with 2 to 4 carbon atoms, or a halogen atom, a radical of the formula: wherein R' 6  represents a hydrogen, an alkyl radical with 1 to 4 carbon atoms, an alkoxy radical with 1 to 4 carbon atoms, a halogen or an acetamido radical, and R' 5  represents either a radical of the formula V above or a radical of the formula: C 6 H 5 -CO-CH 2 - 3) t is 1 or 2 If t=1, R is chosen: Either from the group of meanings (a') in which R represents a linear or branched alkyl radical with up to 18 carbon atoms, an alkenyl radical with 3 to 18 carbon atoms, an alkyl radical with 2 to 4 carbon atoms substituted by one or two hydroxyl radicals, a prop-2-ynyl radical, a -C(C 6 H 5 ) 3  radical, a -C(CH 3 ) 3  radical, a -CH(C 6 H 5 ) 2  radical, a radical of the formula: -CH 2 -(CH 2 ) p -CH 2 -NH 2 , in which p is 0 or 1, a radical of the formula: in which R 7  represents OH or an alkoxy radical with 1 to 5 carbon atoms, a radical of the formula: -(CH 2 ) w -COR 7  in which w is 1 to 5 and R 7  is as defined above, and a radical of the formula: -(CH 2 ) v -R 8 , in which v is 0, 1 or 2 such that if v=1 R 8  represents -C 6 H 5 , a 2-thienyl radical or a 2-pyridyl-N- oxide radical and if v=0 or 2 R 8  represents a 2-pyridyl-N-oxide radical; or from the group of meanings (b') in which R represents a radical of the formula: wherein R' represents an alkyl radical with 1 to 4 carbon atoms and m is 1 or 2; a radical of the formula: in which m is as defined above and B is a divalent radical of the formula: and or R is a radical of the formula: -(CH 2 ) x - CH 2 -NHA in which x is I or 2 and A is as defined above but cannot represent H; a radical of the formula: in which x is I or 2 and R 9  represents a glucosamino radical; -NH-NH 2 -NHOH; a radical of the formula: a radical of the formula: wherein r" represents a hydrogen atom or an alkyl radical with 1 to 3 carbon atoms; a radical of the formula: in which R"' and R"" each independently represents an alkyl radical with 1 to 3 carbon atoms, or r"' and r"" together with the nitrogen atom, form a morpholino, piperidino, pyrrolidino or N'-methyl-piperazino radical; a radical of the formula: in which R 10  is as defined under R 7  and R 9 , and A and x are as defined above, but A cannot represent H; or a radical of the formula: -(CH 2 ) z -R 11  in which z is 0, 1 or 2, and if z=0 R 11  represents a 1-naphthyl radical, a 2-naphthyl radical, a 2-pyridyl radical, a 2-pyridyl radical substituted by a nitro group or an alkyl radical with 1 to 4 carbon atoms, if z=1 R 11  represents a 1-naphthyl radical, a 2-naphthyl radical, a 2-tetrahydrofuryl radical, a 2-furyl radical, a 2-pyridyl radical, a 2-pyridyl radical substituted by a nitro group or an alkyl radical with 1 to 4 carbon atoms, if z=2 R 11  represents a 2- pyridyl radical or a 2-pyridyl radical substituted by a nitro group or an alkyl radical with 1 to 4 carbon atoms; or R is a radical of the formula: in which y is 0 or 1 such that if y is 0 or 1 and q is either 2 or 3 R 12  represents an alkoxy radical with 1 to 5 carbon atoms or a branched or unbranched alkyl radical with up to 4 carbon atoms or if q is 1 R 12  represents an alkylsulphonyl radical, an acetamido radical, an amino radical, a dialkylamino radical, a phenoxy radical, a cyclohexyl radical, a methylene-dioxy radical, a nitro radical, a phenyl radical, a trifluoromethyl radical, an alkylthio radical or an alkyl-sulphinyl radical, the alkyl groups of which have 1 to 5 carbon atoms, or if y is 1 and q is 1 R 12  represents a halogen atom, an alkoxy radical with 1 to 5 carbon atoms or a branched or unbranched alkyl radical with up to 4 carbon atoms, a radical of the formula -(CH 2 ) r -COR 14  in which r is 1, 2, 3, 4 or 5 and R 14  is as defined under R 9 ; a 1, 2-dichloro-vinyl radical, a -CO-NH 2  radical a -CH(C 6 H 4 -p-OCH 3 ) 2  radical or a -C(CH 3 ) 2 -(C 6 H 4 -p-OCH 3 ) radical if t=2 R represents an alkylene radical with 2 to 4 carbon atoms or an alkylene radical substituted by 1 or 2 hydroxyl radicals, or a butenylene radical or a radical of the formula: -(CH 2 ) 2 -SO 2 -(CH 2 ) 2 -, with the proviso that in any single compound A cannot be as defined in 2 (a) when R (with t=1) is as defined in 3 (a'). The compositions may be in conventional forms for topical or oral application including lacquers, wavesetting lotions, creams, gels, orally ingestible preparations and permanent waving preparations.