Patent SG-11201406977T-A (SG)
Title: Combination therapy involving antibodies against claudin 18.2 for treatment of cancer
Inventor: SAHIN UGUR
IPC: A61K45/06
Filed: 2013-05-21
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 28 November 2013 (28.11.2013) WIPOIPCT (10) International Publication Number WO 2013/174510 A1 (51) International Patent Classification: A61K39/395 (2006.01) A61K 45/06 (2006.01) C07K16/30 (2006.01) (21) International Application Number: (22) International Filing Date: PCT/EP2013/001504 21 May 2013 (21.05.2013) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: PCT/EP2012/002210 23 May 2012 (23.05.2012) EP (71) Applicants: GANYMED PHARMACEUTICALS AG [DE/DE]; Freiligrathstrasse 12, 55131 Mainz (DE). TRON - Translationale Onkologie an der Johannes Gutenberg- Universitat Mainz gemeinnutzige GmbH [DE/DE]; Lan- genbeckstrasse 1, 55131 Mainz (DE). (72) Inventors: SAHIN, Ugur; Philipp-von-Zabern-Platz 1, 55116 Mainz (DE). TURECI, Ozlem; Philipp-von-Za- bern-Platz 1, 55116 Mainz (DE). MITNACHT-KRAUS, Rita; Taunusstrasse 45, 61169 Friedberg (DE). JACOBS, Stefan, Denis; Friedenstrasse 7, 55252 Mainz-Kastel (DE). UTSCH, Magdalena, Jadwiga; Fingerkrautweg 30b, — 55262 Heidesheim am Rhein (DE). HEINZ, Cornelia, Ad- riana, Maria; Auf den Elfmorgen 22, 55278 Dalheim (DE). STADLER, Christiane, Regina; Darmstadter Strasse 76, 64625 Bensheim (DE). (74) Agents: SCHNAPPAUF, Georg et al.; ZSP Patentan- walte, Partnerschaftsgesellschaft, Radlkoferstrasse 2, 81373 Munchen (DE). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) with (an) indication(s) in relation to deposited biological material furnished under Rule 13bis separately from the description (Rules 13bis.4(d)(i) and 48.2(a)(viii)) — with sequence listing part of description (Rule 5.2(a)) © i-H •t i> i-H o CJ (54) Title: COMBINATION THERAPY INVOLVING ANTIBODIES AGAINST CLAUDIN 18.2 FOR TREATMENT OF CAN­ CER (57) Abstract: The present invention provides combination a therapy for effectively treating and/or preventing diseases associated with cells expressing CLDN18.2, including cancer diseases such as gastric cancer, esophageal cancer, pancreatic cancer, lung cancer, ovarian cancer, colon cancer, hepatic cancer, head-neck cancer, and cancer of the gallbladder and metastases thereof.