baber/WOPTO huggingface dataset:
Patent AU-2019407063-A1 (AU)
Title: Protein solution formulation containing high concentration of an anti-VEGF antibody
Inventor: SIGG JUERGEN
IPC: A61K39/395
Filed: 2019-12-16
Abstract: The present disclosure provides anti-VEGF antibodies formulated as high concentration, aqueous pharmaceutical compositions, suitable for an injection, preferably an intravitreal injection. The aqueous pharmaceutical compositions are useful for delivery of a high concentration of the antibody active ingredient to a patient without high levels of antibody aggregation and without a high level of sub-visible particulate matter. An aqueous composition of the disclosure comprises an antibody having a concentration of at least 50 mg/ml. An aqueous pharmaceutical composition of the disclosure includes a sugar, a buffering agent, and a surfactant.
Patent AU-2019427102-A1 (AU)
Title: Heat transfer prevention method for wellbore heating system
Inventor: HANSEN HENNING
IPC: E21B43/24
Filed: 2019-11-20
Abstract: A method for thermally insulating a power cable (9) or other temperature sensitive equipment from a wellbore tool comprising a heater (1). The wellbore tool is deployed at an end of the power cable (9) in a well. A flow restrictor (4) is deployed in an annular space between the heater (1) and a wellbore tubular (2). The heater (1) is axially spaced apart from the power cable (9) such that the heater (1) is disposed on one side of the flow restrictor (4) and a connection to the power cable (9) is disposed on another side of the flow restrictor (4). A thermal insulator is introduced into the annular space on the one side of the flow restrictor (4) and the heater (1) is operated.
Patent AU-2019473645-A1 (AU)
Title: System and method for multiple discontinuous receptions for one cell group
Inventor: DONG FEI
IPC: H04W76/28
Filed: 2019-11-06
Abstract: In one embodiment, a method performed by a wireless communication device includes receiving a first discontinuous reception (DRX) configuration corresponding to a first DRX group including a first subset of cells (e.g., a first cDRX group) in a cell group and receiving a second, different DRX configuration corresponding to a second DRX group including a second subset of cells (e.g., a second cDRX group) in the cell group.
Patent WO-2021030875-A1 (WO)
Title: Moving-bed particle heat exchanger
Inventor: SOO TOO YEN CHEAN
IPC: F28D7/16
Filed: 2020-08-21
Abstract: A particle heat exchanger comprising: a housing including an inlet located at the top of the housing, and an outlet located below the inlet, the housing configured to enclose a flow of heat transfer particles which flows downwardly from the inlet to the outlet within the housing; at least one heat transfer tube enclosed in the housing and in contact with the flow of heat transfer particles therein, each heat transfer tube extending substantially parallel to an axis extending between the inlet and outlet of the housing; and at least one divider located between the inlet and outlet of the housing, the at least one heat transfer tube extending through each divider, each divider including at least one opening configured to form at least one flow constriction in the flow of heat transfer particles between the inlet and outlet of the housing.
Patent WO-2021097521-A1 (WO)
Title: Procédé de fourniture de cellules immunitaires à fonction améliorée
Inventor: SHU RUNZHE
IPC: C12N5/078
Filed: 2020-11-18
Abstract: La présente invention concerne des procédés de production de cellules immunitaires à fonction améliorée. Plus particulièrement, la présente invention concerne un procédé d'amélioration de la fonction d'une cellule immunitaire comprenant la modification d'une cellule immunitaire pour inhiber la fonction d'au moins un gène choisi dans le groupe constitué par RC3H1, RC3H2, A2AR, FAS, TGFBR1 et TGFBR2. L'invention concerne également un procédé comprenant la modification d'une cellule souche ou progénitrice capable de se différencier en une cellule immunitaire pour inhiber la fonction d'au moins un gène choisi dans le groupe constitué par RC3H1, RC3H2, A2AR, FAS, TGFBR1 et TGFBR2. L'invention concerne également des cellules immunitaires ou des cellules souches fabriquées par les présents procédés, ainsi que l'utilisation de cellules immunitaires dans un traitement thérapeutique.
Patent AU-2020201429-A1 (AU)
Title: Human FcRn-binding modified antibodies and methods of use
Inventor: HARTMANN GUIDO
IPC: C07K16/22
Filed: 2020-02-27
Abstract: Herein is reported the use of an antibody comprising an Fc-region with abolished FcRn binding for the transport of a soluble receptor ligand from the eye over the blood-ocular-barrier into the blood circulation.
Patent AU-2020203671-A1 (AU)
Title: Resource Crew Management
Inventor: GRAFTON DARRIN JOHN
IPC: G06Q50/14
Filed: 2020-06-04
Abstract: An online booking system caters for the corporate booking of the travel of a number of people to a single destination or multiple destinations by providing a file with details of the trip destination, the people involved and the criteria which override the normal corporate travel criteria. The booking system then merges this with the normal corporate travel criteria and any external profile criteria of the individuals and books individuals to the destination before issuing the bookings.
Patent AU-2020206760-A1 (AU)
Title: Improved bone anchor and related devices, systems, and methods
Inventor: DIAZ ROBERTO
IPC: A61F2/00
Filed: 2020-01-08
Abstract: Disclosed herein are various attachment devices for anchoring tendons within bone and associated methods and systems. Disclosed is a device for repairing/reconstructing a ligament rupture via compression and grasping. The device includes first and second elongate body portions, where each elongate body portion includes at least one elongate member having a first end and a second end and a plurality of bands coupled to the at least one elongate member. The device further includes a connection structure disposed at a distal end of the at least one elongate member connecting the first and second elongate body portions such the first and second elongate body portions are movable in relation to each other. The device also includes an lumen defined by the first and second elongate body portions for insertion of a tendon graft.
Patent AU-2020211900-A1 (AU)
Title: Systems and methods for instillation purging
Inventor: MOORE BRETT L
IPC: A61M1/00
Filed: 2020-01-20
Abstract: An apparatus for treating a tissue site comprising a negative-pressure source configured to be fluidly coupled to the tissue site; an instillation source configured to be fluidly coupled to the tissue site; and a controller operatively coupled to the negative-pressure source and to the instillation source. The controller can be configured to operate the negative-pressure source and the instillation source to intermittently deliver negative pressure to the tissue site for a negative-pressure interval and deliver instillation fluid to the tissue site for an instillation interval. A purge volume of instillation fluid may be delivered to the tissue site at a purge frequency. In some examples, the purge volume may be delivered through the second fluid conductor and removed through the first fluid conductor during a negative- pressure interval.
Patent AU-2020219814-A1 (AU)
Title: Computing system providing blockchain-facilitated semantic interoperability between multiple disparate systems of record (SORs) and related methods
Inventor: CALCO BOB
IPC: G06F16/25
Filed: 2020-02-03
Abstract: A system for propagating an identity state change set about shared identities may include a plurality of systems of record (SORs), and a management server cooperating with the plurality of SORs and configured to: detect discrete Create-Retrieve-Update-Delete (CRUD) operations on a given SOR related to at least one shared identity to generate an identity state change set corresponding to a current state of the at least one shared identity; transact the identity state change set, with associated metadata, to a distributed immutable long-term storage as a current transaction; propagate the identity state change set and associated metadata to replicate a current state of the at least one shared identity as of the current transaction to at least one domain cache instance, and; synchronize the current state of the at least one shared identity across the plurality of SORs from the at least one domain cache instance.
Patent AU-2020220963-A1 (AU)
Title: Salivary biomarkers of brain injury
Inventor: BELLI ANTONIO
IPC: C12Q1/6883
Filed: 2020-02-14
Abstract: Methods of diagnosing, monitoring, treating, and predicting the course of traumatic brain injury (TBI), including mild traumatic brain injury (mTBI), include determining a level of at least one RNA biomarker (e.g., miRNA) in a saliva sample from a subject. Also described are sensor elements, detection systems, compositions, and kits for diagnosing, monitoring, treating, and predicting the course of TBI.
Patent AU-2020224136-A1 (AU)
Title: Methods of treating ocular cancer using anti-MET antibodies and bispecific antigen binding molecules that bind MET
Inventor: SCHWARTZ GARY
IPC: A61P35/00
Filed: 2020-02-20
Abstract: Provided herein are methods of treating ocular cancer such as uveal melanoma, orbital lymphoma, retinoblastoma, and medulloepithelioma using antibodies and bispecific antigen-binding molecules that bind MET or antibody-drug conjugates (ADCs) comprising the antibodies or bispecific antigen-binding molecules. The bispecific antigen-binding molecules comprise a first and a second antigen-binding domain, wherein the first and second antigen-binding domains bind to two different epitopes of the extracellular domain of human MET. The ADCs comprise the antibodies or bispecific antigen-binding molecules provided herein linked to a cytotoxic agent, radionuclide, or other moiety. The antibodies and bispecific antigen-binding molecules are capable of blocking the interaction between human MET and its ligand HGF. A subject having ocular cancer, for example, an uveal melanoma expressing c-Met, can be treated by administering to the subject an antibody, a bispecific antigen-binding molecule, or an ADC thereof.
Patent AU-2020231160-A1 (AU)
Title: Marine motor with a dual-flow exhaust gas recirculation system
Inventor: CORNWELL RICHARD
IPC: B63H20/00
Filed: 2020-03-05
Abstract: There is provided a marine motor (2) having an internal combustion engine (100) having an engine block (110) with at least one cylinder, an air intake (120), an exhaust conduit (130) configured to direct a flow of exhaust gas from the at least one cylinder, and an exhaust gas recirculation system (140) configured to recirculate a portion of the flow of exhaust gas from the exhaust conduit to the air intake. The exhaust gas recirculation system (140) includes a first exhaust gas recirculation circuit (141) with at least one first EGR cooler (151) having a first overall conductance, and includes a second exhaust gas recirculation circuit (145) with at least one second EGR cooler (152) having a second overall conductance which is greater than the first overall conductance. The exhaust gas recirculation system (140) also includes flow control means (143, 147) configured to selectively vary the relative proportions of first and second flows of recirculated exhaust gas through the first and second exhaust gas recirculation circuits to allow the amount of exhaust gas cooling to be varied.
Patent AU-2020239719-A1 (AU)
Title: Sweetener composition and food containing same
Inventor: MORITA TOYOSHIGE
IPC: A23L27/00
Filed: 2020-09-24
Abstract: ] 
The present invention provides a sweetener composition 
that can be used for food as a sugar substitute sweetener.  
Specifically, the sweetener composition contains 
5 rebaudioside 0 and rebaudioside N as active ingredients, or 
contains at least one of rebaudioside D and rebaudioside M 
and at least one of rebaudioside 0 and rebaudioside N as 
active ingredients. In addition, the sweetener composition 
is used in combination with an additional sweetener.
Patent AU-2020242361-A1 (AU)
Title: A method to improve the agronomic characteristics of plants
Inventor: REINHEIMER RENATA
IPC: C12N15/29
Filed: 2020-03-18
Abstract: The present invention describes a method to improve the agronomic characteristics of plants that comprises genetically transforming said plant with a nucleic acid sequence encoding RAMOSA1 transcription factor, where said plant is selected from the group consisting of gramineous monocotyledons of the BOP clade, monocotyledons-non-grasses and dicotyledons. In addition, sequences of DNA, cDNA, protein, cells, uses, genetic transformation method of plants and transformed plants are described.
Patent AU-2020245415-A1 (AU)
Title: Combination of nasal gene delivery and oral cinnamic acid, oleamide or gemfibrozil for lysosomal stoarge disorders
Inventor: PAHAN KALIPADA
IPC: A61K48/00
Filed: 2020-03-20
Abstract: Provided herein are methods for the treatment of lysosomal storage disease comprising administration of genes encoding for a lysosomal enzyme and a pharmaceutical agent. Combining gene therapy with pharmaceutical compositions by co-administration not only further enhances the effects of each individual therapy, but also provides a multi-faceted approach to treatment because of the varying mechanism of action of each individual composition.
Patent AU-2020260388-A1 (AU)
Title: System for detachably coupling an unmanned aerial vehicle within a launch tube
Inventor: ANDRYUKOV OLEKSANDR
IPC: B64C39/00
Filed: 2020-10-26
Abstract: An unmanned aerial vehicle (UAV) launch tube (100) that has at least one layer of prepeg 
substrate disposed about an aperture (106) to form a tube, a sabot (110) disposed in an 
5 interior of said tube (100), said sabot (110) having a first clasp tab (126), and a clasp (124) 
detachably coupled to said first clasp tab and contacting an inner circumferential wall (102) 
of said tube (100) so that said clasp (124) is rotationally constrained by the inner 
circumferential wall (102) and said first clasp tab (126).  
0 Figure 1 
18
1/6 
106 
102 
104 
FIG. 1 
100 
108 
120 -122 
130 5 -124 
110 
140 128 
114 
*4 136 --
413 
138 
- 132 
116 112 
100 
102 102 
20020 
1401114 
136 
138-- 138 
132132 
136 
300 
FIG. 2 FIG. 3
Patent AU-2020262159-A1 (AU)
Title: Apparatus, method or computer program for generating an output downmix representation
Inventor: REUTELHUBER FRANZ
IPC: H04S1/00
Filed: 2020-04-22
Abstract: An apparatus for generating an output downmix representation from an input downmix representation, wherein at least a portion of the input downmix representation is in accordance with a first downmixing scheme, comprises: an upmixer (200) for upmixing at least the portion of the input downmix representation using an upmixing scheme corresponding to the first downmixing scheme to obtain at least one upmixed portion; and a downmixer (300) for downmixing the at least one upmixed portion in accordance with a second downmixing scheme different from the first downmixing scheme.
Patent AU-2020269125-A1 (AU)
Title: Substituted 3,4,12,12a-tetrahydro-1h-(1,4)oxazino(3,4-c)pyrido(2,1-f)(1,2,4)triazine-6,8-dione, pharmaceutical composition, and methods for preparing and using same
Inventor: IVACHTCHENKO ALEXANDRE VASILIEVICH
IPC: A61P31/16
Filed: 2020-03-27
Abstract: Influenza is an acute respiratory tract infection caused by the influenza virus. In light of the fact that influenza presents a serious threat to public health, the search for new anti-influenza drugs with improved characteristics is expedient. The authors have found that a previously unknown compound of general formula 1, a stereoisomer thereof, a prodrug, a pharmaceutically acceptable salt, a solvate hydrate thereof and a crystalline or polycrystalline form thereof are an effective means for the prevention and treatment of viral diseases, including influenza. The compound is represented by formula 1: (I) where R
Patent AU-2020277640-A1 (AU)
Title: Haptoglobin for use in treating an adverse secondary neurological outcome following a haemorrhagic stroke
Inventor: HUGELSHOFER MICHAEL
IPC: A61K38/42
Filed: 2020-05-15
Abstract: The present invention relates generally to methods for treating or preventing an adverse secondary neurological outcome in a subject following a haemorrhagic stroke accompanied by extravascular erythrolysis and release of cell-free haemoglobin (Hb) into a cerebral spinal fluid (CSF) comprising exposing the CSF of a subject in need thereof to a therapeutically effective amount of haptoglobin (Hp) and for a period of time sufficient to allow the Hp, or the functional analogue thereof, to form a complex with, and thereby neutralise, the cell-free Hb. Aspects of the invention further relate to compositions and kits of an artificial CSF comprising Hp.
Patent AU-2020284169-A1 (AU)
Title: MCT-based nutrition blend for providing health benefits in animals
Inventor: PAN YUANLONG
IPC: A23K10/00
Filed: 2020-05-29
Abstract: A method for treating sarcopenia or muscle atrophy in an animal and a method of increasing weight gain, increasing fat gain, or maintaining lean body mass in an animal in need thereof, is provided. The methods can comprise orally administering a composition comprising a therapeutically effective amount of medium chain triglycerides to the animal.
Patent AU-2020286993-A1 (AU)
Title: Indicator material comprising a polymeric gel carrier and polymeric indicator
Inventor: IVÁN BÉLA
IPC: G01N21/77
Filed: 2020-06-03
Abstract: The invention relates to a polymeric indicator fixed in a polymeric gel carrier, wherein the polymeric gel carrier comprises a hydrophilic polymer, wherein the polymeric indicator and the hydrophilic polymer are present together in the form of a combined cross-linked hydrogel network fixed by chemical bonds. The invention further relates to a method for preparing a polymeric indicator fixed in a polymeric gel carrier and to a sensor for measuring pH, which comprises the polymeric indicator fixed in a polymeric gel carrier.
Patent AU-2020295064-A1 (AU)
Title: A method and device eor monitoring the status of a high-level disinfection device
Inventor: LIU TONG
IPC: H05B45/44
Filed: 2020-06-21
Abstract: There is disclosed a method of monitoring the functionality of individual irradiation emitters within a UVC irradiation disinfecting device comprising: supplying a constant current supply to at least one irradiation emitter; sensing the voltage across the at least one irradiation emitter; sensing the current drawn by the at least one irradiation emitter; analysing the sensed voltage and the sensed current against predetermined values; and determining a failure state of the at least one irradiation emitter based on said analysis.
Patent AU-2020302837-A1 (AU)
Title: Combined light and electrical stimulation of light-sensitive neural tissue
Inventor: SCOTT-YOUNG RACHAEL
IPC: A61N5/06
Filed: 2020-06-26
Abstract: Disclosed is a method for stimulating neural tissue, where the neural tissue includes one or more neurons genetically modified to express a light-sensitive protein. The method comprises applying a light stimulus and an electrical stimulus to the neural tissue, thereby triggering membrane depolarisation in at least one of the neurons. Also disclosed is an apparatus for applying the disclosed method. The apparatus includes a light-stimulation device for selectively applying a light stimulus and an electrical-stimulation device for selectively applying an electrical stimulus to the neural tissue.
Patent AU-2020303219-A1 (AU)
Title: Pipe clip
Inventor: NEWTON IAN ROY
IPC: F16L3/123
Filed: 2020-06-23
Abstract: A pipe clip (2) operable to be fixed to a mounting position, the pipe clip comprising a pipe receiving portion and a mounting portion (4) connected by a base portion (12), the base portion (12) configured to allow the pipe clip to be seated on the mounting position.
Patent AU-2020315579-A1 (AU)
Title: Method of manufacturing high packing composite adsorbent bed, adsorber including the same, and adsorption based gas separation using the adsorber
Inventor: COIGNET PHILIPPE A
IPC: B01D53/047
Filed: 2020-07-11
Abstract: An adsorbent bed, including at least one elementary composite structure that includes adsorbent particles in a polymer matrix, wherein the adsorbent bed has a bed packing, ρ
Patent AU-2020331330-A1 (AU)
Title: Fused ring heteroaryl compounds as ripk1 inhibitors
Inventor: YOON CHEOLHWAN
IPC: A61P35/00
Filed: 2020-08-09
Abstract: The invention provides novel substituted heterocyclic compounds represented by Formula I, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of RIPK1 and the therapeutic methods.
Patent AU-2020354631-A1 (AU)
Title: Plant supplement delivery assemblies, plant supplement delivery assembly inserts, and methods for delivering plant supplements
Inventor: SIMMONS KEVIN L
IPC: A01C15/16
Filed: 2020-09-24
Abstract: Plant supplement delivery assemblies are provided that can include an insert having collapsible insert sidewalls complimentary to the exterior sidewalls of the assembly housing, the collapsible insert sidewalls defining at least a portion of a container configured to house a plant supplement. Plant supplement delivery inserts are also provided that can include collapsible sidewalls extending between a discharge end and a butt end to define a container configured to house plant supplement. The butt end can be configured to operably engage a biased member, and the insert can further include a stem extending from the discharge end. The stem can define a conduit in fluid communication with the container. Methods for providing plant supplements include operably engaging a biased member with a butt end of a container to collapse sidewalls of the container and provide plant supplement from the container through a stem into a plant.
Patent AU-2020357178-A1 (AU)
Title: Biomarker-based treatment of focal segmental glomerulosclerosis and diabetic kidney disease
Inventor: REILLY JOHN FRANCIS
IPC: C07D235/04
Filed: 2020-10-05
Abstract: Disclosed are compounds having structural formulas (I)-(XI), and related pharmaceutical compositions. Also disclosed are methods of selecting and treating human subjects suffering from a kidney disease, using the compounds of formulas (I)-(XI), and methods of determining the efficacy of TRPC5 inhibitor therapies using the same.
Patent AU-2020366209-A1 (AU)
Title: mRNA encoding granulocyte-macrophage colony stimulating factor for treating Parkinson's disease
Inventor: HUANG ERIC YI-CHUN
IPC: A61K31/7115
Filed: 2020-10-15
Abstract: The disclosure features lipid nanoparticle (LNP) compositions comprising mRNA molecules encoding human granulocyte macrophage colony stimulating factor (GM-CSF) polypeptides and uses thereof in the treatment of Parkinson's Disease. The LNP compositions of the present disclosure comprise mRNA therapeutics encoding human GM-CSF for use in such treatment.
Patent AU-2020383192-A1 (AU)
Title: Beverage preparation systems with enhanced disposition of motorized actuation
Inventor: NABEIRO RUI MIGUEL
IPC: A47J31/44
Filed: 2020-11-10
Abstract: The present invention discloses beverage preparation systems, for preparing in particular espresso coffee and similar aromatic beverages, based upon a beverage preparation apparatus (1) that comprises a beverage preparation device (2) designed so that it can be driven between open and closed positions by an actuation arrangement (3) that includes an electric motor (31), the operation of which is regulated by control means (4), and thereby collect an individual portion (5) of beverage ingredients, whereby the actuation arrangement (3) is arranged in an advantageous position inside the apparatus (1) and has an enhanced configuration and a smaller construction volume.