Patent AU-2015215843-A1 (AU)
Title: Nanoscale platinum compounds and methods of use thereof
Inventor: SENGUPTA SHILADITYA
IPC: C08F222/06
Filed: 2015-08-18
Abstract: (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date H(10) International Publication Number 12 August 2010 (12.08.2010) PCT W O 2010/091192 A2 (51) International Patent Classification: PARASKAR, Abhimanyu [IN/US]; 43 White Street, C08F 222/06 (2006.01) A61K47/48 (2006.01) Belmont, MA 02478 (US). C08F 22/06 (2006.01) A6JP 35/00 (2006.01) (74) Agents: RESNICK, David, S. et al.; Nixon Peabody C08F 8/42 (2006.01) LLP, 100 Summer Street, Boston, MA 02110-2131 (US). (21) International Application Number:PCT/US2010/023217 (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, 4 February 2010 (04.02.20 10) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, Fl, GB, GD, GE, GH, GM, GT, (25) Filing Language: English HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, (26) Publication Language: English KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, (30) Priority Data: NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, 61/149,725 4 February 2009 (04.02.2009) US SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, 61/240,007 4 September 2009 (04.09.2009) US TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant (for all designated States except US): T H E (84) Designated States (unless otherwise indicated, for every BRIGHAM AND WOMEN'S HOSPITAL, INC. [US/ kind of regional protection available): ARIPO (BW, GH, US]; 75 Francis Street, Boston, MA 02115 (US). GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, (72) Inventors; and ZW), Eurasian (AM, AZ, BY, KG, KZ, MD, RU, TJ, (75) Inventors/Applicants (for US only): SENGUPTA, Shi- TM), European (AT, BE, BG, CH, CY, CZ, DE, DK, EE, laditya [IN/US]; 4613 Steams Hill Road, Waltham, MA ES, Fl, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 02451 (US). SONI, Shivani [IN/US]; 127 Washington MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, Street, Apartment 47, Brighton, MA 02135 (US). TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). [Continued on next page] (54) Title: NANOSCALE PLATINUM COMPOUNDS AND METHODS OF USE THEREOF (57) Abstract: The invention is directed to biocompatible conjugated 15 polymer nanoparticles including a copolymer backbone, a plurality of sidechains covalently linked to said backbone, and a plurality of platinum 1Lum 1i0n 100m compounds dissociably linked to said backbone. The invention is also di -20 rected to dicarbonyl-lipid compounds wherein a platinum compound is dissociably linked to the dicarbonyl compound. The invention is also di 10 rected to methods of treating cancer or metastasis. The methods includes L om i selecting a subject in need of treatment for cancer or metastasis and admin 2 loo 10nm 10m' istering to the subject an effective amount of any of the nanoparticles, compounds, or compositions of the invention. 1:20 1oom lonm 1000mn h30 1, lom 100am 1000am Gl.m 1Bmm boom ON FIG. lB