baber/WOPTO huggingface dataset:
Patent WO-2021207310-A1 (WO)
Title: Menin inhibitors and methods of use for treating cancer
Inventor: LIU TAO
IPC: A61K31/4523
Filed: 2021-04-07
Abstract: The present disclosure provides compounds represented by Formula (I): or a pharmaceutically acceptable salt thereof, wherein R a , R b , R c , R d , L 1 , R 2  B, Q and E are as defined as set forth in the specification. The present disclosure also provides compounds of Formula (I) for use to treat cancer or any other disease, condition, or disorder that is responsive to inhibition of menin. :
Patent WO-2021222105-A1 (WO)
Inventor: MONROE EMILY
IPC: A61F13/15
Filed: 2021-04-26
Abstract: An absorbent article, such as, for example, a diaper (400), that is toxin-free and made from plant-based, biobased, all natural, clean ingredients. In one embodiment, the absorbent article is a diaper (400) made from plant-based resin, comprising: (i) a first layer (110, 410), wherein the first layer (110, 410) is a cotton top sheet with a wax-based coating deposited on an exterior surface of the first layer (adjacent to the wearer's skin, or "user-facing"); and (ii) a second layer (120, 420), wherein the second layer (120, 420) is an acquisition/distribution layer (ADL), and wherein the ADL is comprised of two sub-layers of different materials, a first sublayer (210) comprising an apertured film acquisition sub-layer disposed on top of, and laminated to, a second sub-layer (220) comprising a non-woven acquisition layer.
Patent WO-2022182375-A1 (WO)
Inventor: POMEROY JAMES W
IPC: F01N13/18
Filed: 2021-05-04
Abstract: La présente invention concerne un élément de soufflet (10) destiné à être utilisé pour relier deux interfaces de plomberie l'une à l'autre. L'élément de soufflet est une conception généralement creuse ayant des extrémités de manchon (12, 14), chacune d'elles étant reliée à une extrémité d'une autre interface. L'élément de soufflet présente une section centrale de corps de soufflet flexible qui se déplace pour s'adapter à un mauvais alignement hors axe opérationnel, tout en pouvant absorber le vide et des différentiels de pression. Le soufflet selon l'invention résiste à une implosion sous vide et à une mise sous pression interne. La section centrale flexible est pourvue d'une pluralité de spires (34, 36, 38) orientées radialement vers l'extérieur sur un axe horizontal. Le soufflet fonctionne pour s'adapter à un mauvais alignement entre les deux interfaces de plomberie.
Patent WO-2021226180-A1 (WO)
Inventor: ARAVA LEELA
IPC: H01M50/417
Filed: 2021-05-05
Abstract: L'invention concerne un dispositif électrochimique donné à titre d'exemple qui peut comprendre une anode, une cathode et une structure bipolaire disposée entre l'anode et la cathode. Le séparateur peut être au moins partiellement revêtu d'une membrane poreuse sous-nanométrique. La batterie peut être une batterie classique dans laquelle l'anode et la cathode sont au moins partiellement immergées dans une solution électrolytique. En variante, la batterie peut être une batterie à semi-conducteur disposée entre l'anode et la cathode et ayant un électrolyte à semi-conducteur, qui peut servir de séparateur.
Patent WO-2021236642-A1 (WO)
Title: Retrieving a stuck downhole component
Inventor: AL YAHYA HANY
IPC: E21B31/113
Filed: 2021-05-18
Abstract: A wellbore assembly including a cable disposed within a wellbore and a fishing jar assembly coupled to the cable. The fishing jar assembly includes a housing assembly, a mandrel assembly, a fishing assembly, and an actuator. The housing assembly has an inwardly projecting shoulder defining an anvil surface and a hydraulic fluid chamber housing hydraulic fluid. The mandrel is movable along a central axis of the housing assembly and has an outwardly projecting shoulder that defines a hammering surface to strike the anvil surface. The mandrel assembly defines a piston disposed within the hydraulic fluid chamber. The fishing assembly engages a component stuck within the wellbore. The actuator moves the piston of the mandrel assembly along the longitudinal axis to pressurize the hydraulic fluid until the hydraulic fluid bleeds past a fluid port allowing the mandrel assembly to trip to strike the anvil surface with the hammering surface.
Patent WO-2021252199-A1 (WO)
Title: Surgical robotic system instrument engagement and failure detection
Inventor: WELLS BRIAN K
IPC: A61B34/30
Filed: 2021-05-27
Abstract: A surgical robotic arm includes an instrument having a coupler rotatable about a longitudinal axis, the coupler including: a drive screw; a drive nut threadably coupled to the drive screw, the drive nut movable along the longitudinal axis in response to rotation of the drive screw; and a drive member coupled to the drive nut and movable in response to movement of the drive nut. The surgical robotic arm also includes an instrument drive unit having: a motor configured to engage the coupler and rotate about the longitudinal axis to rotate the coupler and the drive screw; one or more sensors configured to measure one or more properties of the motor; and a controller coupled to the sensor(s) and the motor. The controller is configured to control the motor based on the property of the motor.
Patent WO-2022005714-A1 (WO)
Title: Coiled vascular access instrument and related systems
Inventor: BURKHOLZ JONATHAN KARL
IPC: A61M25/06
Filed: 2021-06-09
Abstract: A vascular access instrument configured to be inserted through a vascular access device, such as a catheter assembly. The vascular access instrument includes a wire (42), which is monolithically formed as a single unit. The wire (42) includes a coil portion (44), which includes multiple loops (46) wound around a central coil axis (48). The wire (42) includes a core portion (50) extending through the coil portion (44) and aligned with the central axis (48). The wire (42) includes a bent portion (52) connecting a distal end of the coil portion (44) with a distal end of the core portion (50). The bent portion (52) may be blunt and atraumatic.
Patent WO-2021257890-A1 (WO)
Inventor: RAUE ANDREAS
IPC: C12Q1/6851
Filed: 2021-06-17
Abstract: L'invention concerne un procédé d'identification de biomarqueurs de réponse prédictive (PRB) pour un régime thérapeutique. Les PRB peuvent être utilisés pour identifier une population de patients appropriés ou inappropriés pour le régime thérapeutique.
Patent WO-2021257936-A1 (WO)
Title: Cannabinoid syrup and methods for making and using same
Inventor: SEIDEL ERIC
IPC: A61K47/44
Filed: 2021-06-18
Abstract: Provided are water-soluble and/or alcohol-soluble cannabinoid syrups recovered from a dispersion comprising a sugar, sugar alcohol, or sugar substitute; water (e.g., fruit or plant water); and a cannabinoid, the dispersion comprising less than about 10% by weight of alcohol. Also provided are products comprising the cannabinoid syrup prepared by the disclosed method, including a variety of comestible products.
Patent WO-2022006491-A1 (WO)
Inventor: ANDINO-PAVLOVSKY RAUL
IPC: C12N15/41
Filed: 2021-07-02
Abstract: La présente divulgation concerne d'une manière générale, entre autres, des constructions d'acides nucléiques codant pour un génome d'entérovirus modifié qui est exempt de séquences partielles ou complètes d'acides nucléiques codant pour des protéines structurales virales. La divulgation concerne également des compositions et des procédés utiles pour produire des particules interférentes défectueuses d'entérovirus et utiles pour la prévention et/ou le traitement de divers états de santé tels que des maladies immunitaires et des infections virales.
Patent WO-2022031612-A1 (WO)
Inventor: DEBLASIO NICHOLAS
IPC: A47L11/30
Filed: 2021-08-02
Abstract: La présente invention concerne un appareil de nettoyage des sols (10) alimenté par batterie. L'appareil de nettoyage des sols (10) peut fonctionner dans divers modes en fonction de la capacité de la batterie (22), tel qu'un mode de fonctionnement normal (40) et un mode basse consommation (42).
Patent WO-2022040228-A1 (WO)
Inventor: DEVILLIERS ANTON J
IPC: G03F7/20
Filed: 2021-08-17
Abstract: A method of pattern alignment is provided. The method includes identifying a reference pattern positioned below a working surface of a wafer. The wafer is exposed to a first pattern of actinic radiation. The first pattern is a first component of a composite pattern. The first pattern of actinic radiation is aligned using the reference pattern. The wafer is exposed to a second pattern of actinic radiation. The second pattern is a second component of the composite pattern and exposed adjacent to the first pattern. The second pattern of actinic radiation is aligned with the first pattern of actinic radiation using the reference pattern.
Patent WO-2022046512-A1 (WO)
Title: Visualization of non-conformance of objects via heat maps
Inventor: Stone Kristen
IPC: G06T17/00
Filed: 2021-08-19
Abstract: An image of an object is received into an augmented reality (AR) device. Information is received for identifying the object or a component associated with the object. A database is accessed to retrieve data relating to the object or the component associated with the object, and a heat map is created as a function of the data relating to the object or the component associated with the object. The heat map is displayed on a computer display device.
Patent WO-2022047127-A1 (WO)
Title: Compositions and methods for detection of coronavirus
Inventor: CHIU CHARLES
IPC: C12Q1/70
Filed: 2021-08-27
Abstract: The disclosure provides for primers that can detect SARS-CoV-2 nucleic acids in a highly specific and efficient manner using loop-mediated isothermal amplification.
Patent WO-2022240434-A1 (WO)
Inventor: LIND AMANDA
IPC: G01S15/86
Filed: 2021-08-31
Abstract: An autonomous vehicle includes a first ultrasonic sensor and a second ultrasonic sensor that is included in a daisy chain with the first ultrasonic sensor, wherein the first ultrasonic sensor is electrically connected to the second ultrasonic sensor in the daisy chain by way of a twisted pair wire. The autonomous vehicle further includes an electronic control unit (ECU) for the first ultrasonic sensor and the second ultrasonic sensor, the ECU is included in the daisy chain with the first ultrasonic sensor and the second ultrasonic sensor, wherein the ECU is electrically connected to the first ultrasonic sensor and the second ultrasonic sensor by way of the twisted pair wire, and further wherein the ECU is in bidirectional communication with the first ultrasonic sensor and the second ultrasonic sensor by way of differential signaling over the twisted pair wire.
Patent WO-2022056384-A1 (WO)
Inventor: FARRIS JEFFERY A
IPC: A61L27/56
Filed: 2021-09-13
Abstract: A method for forming a thermoplastic body having regions with varied material composition and/or porosity. Powder blends comprising a thermoplastic polymer, a sacrificial porogen and an inorganic reinforcement or filler are molded to form complementary parts with closely toleranced mating surfaces. The parts are formed discretely, assembled and compression molded to provide a unitary article that is free from discernible boundaries between the assembled parts. Each part in the assembly has differences in composition and/or porosity, and the assembly has accurate physical features throughout the sections of the formed article, without distortion and nonuniformities caused by variable compaction and densification rates in methods that involve compression molding powder blends in a single step.
Patent WO-2022060678-A1 (WO)
Inventor: HEALY JANE ANNE
IPC: A61K39/395
Filed: 2021-09-14
Abstract: La présente divulgation concerne des polythérapies comprenant un antagoniste du récepteur de mort programmée 1 (PD-1), un antagoniste du gène d'activation des lymphocytes 3 (LAG3) et du lenvatinib ou un sel pharmaceutiquement acceptable de celui-ci, ainsi que l'utilisation de ces polythérapies dans le traitement du cancer.
Patent WO-2022061171-A1 (WO)
Title: Combination therapies with disulfiram
Inventor: JACOBSON RACHEL
IPC: A61P19/06
Filed: 2021-09-17
Abstract: Disclosed herein are methods and compositions for inhibiting and/or reducing pyroptotic cell death in a cell, the composition comprising disulfiram as an active agent and a potentiating ingredient (e.g., tert-Butylhydroquinone (TBHQ)). Also disclosed are methods and compositions for limiting the progression of acute respiratory distress syndrome (ARDS) in patients with or without acute lung injury (ALI), the method comprising administrating a composition comprising disulfiram and a potentiating ingredient (e.g., TBHQ).
Patent WO-2022086666-A1 (WO)
Title: Flow cytometers including tilted beam shaping optical components, and methods of using the same
Inventor: CONROY BRIANNA
IPC: G01N1/00
Filed: 2021-09-22
Abstract: Flow cytometers including tilted beam shaping optical components are provided. In certain embodiments, the subject flow cytometers include a flow cell, a light source configured to produce a beam for irradiating particles in the flow cell at an interrogation point, and a tilted beam shaping optical component positioned between the light source and the flow cell. In such embodiments, the tilted beam shaping optical component is configured to generate beam ellipticity by creating astigmatism in the beam. In some embodiments, the tilted beam shaping optical component is a lens. In other embodiments, the tilted beam shaping optical component is a concave mirror. Methods of analyzing a sample using a flow cytometer including a tilted beam shaping optical component are also provided.
Patent WO-2022072749-A1 (WO)
Inventor: LOZHKO ANDRIY
IPC: B65D75/58
Filed: 2021-09-30
Abstract: A packaging arrangement for a bundle of cable includes a planar packaging blank extending in a longitudinal direction from a first end to a second end. The blank includes a middle region extending from the first end to the second end between a first fold line and a second fold line, a first side extending from the first end to the second end and including a plurality of first flaps extending from the first fold line in a direction away from the second side in a direction perpendicular to the longitudinal direction, and a second side extending from the first end to the second end and including a plurality of second flaps extending from the second fold line in a direction away from the first side in a direction perpendicular to the longitudinal direction. The blank is configured to be rolled into a cylindrical shape such that the first end overlaps the second end. The plurality of first flaps are configured to be folded radially inward relative to the cylindrical blank, and the plurality of second flaps are configured to be folded radially inward relative to the cylindrical blank.
Patent WO-2022081889-A1 (WO)
Title: Procédé et systèmes d'analyse de phytothérapie permettant l'optimisation de la recherche à l'échelle
Inventor: SMALL-HOWARD ANDREA
IPC: G06F19/10
Filed: 2021-10-14
Abstract: Sont divulguées par les présentes des analyses de phytothérapies destinées à un procédé d'optimisation de la recherche à l'échelle (PhAROS) permettant de découvrir et/ou d'optimiser des thérapies polypharmaceutiques, le procédé PhAROS consistant : à analyser, dans un seul espace de calcul, des données provenant d'une pluralité de systèmes de thérapies classiques (TMS), l'analyse faisant appel à des dictionnaires transculturels pour permettre des recherches dans des ensembles de données TMS distincts mettant en œuvre différents types d'épistémologies et de terminologies, l'analyse utilisant des données renvoyées par une interrogation pour identifier de nouvelles compositions polypharmaceutiques et/ou polypharmaceutiques optimisées.
Patent WO-2023063963-A1 (WO)
Title: System and computer-implemented method for seamless consumption of automations
Inventor: VISAN SORIN
IPC: G06Q10/10
Filed: 2021-10-29
Abstract: A system and a method for accessing at least one automation from an automation store are provided. The method comprises receiving a user input indicative of selection of at least one automation for accessing from a plurality of automations displayed in the automation store, and automatically uploading, in response to receiving the user input, the selected automation to a personal workspace of the user from the automation store. The automations are accessed via one or more Application Programming Interface (API) calls directed to an automation cloud server. Further, the method comprises generating a notification indicative of upload of the selected automation for accessing the automation. The uploaded automation is displayed in a software robot assistant associated with the user. Furthermore, the method comprises displaying the generated notification in an application interface associated with the automation store and displaying the selected automation in the personal workspace in the application interface.
Patent WO-2022109292-A1 (WO)
Inventor: CHEN BEIBEI
IPC: A61K31/4709
Filed: 2021-11-19
Abstract: Cette invention porte sur des composés pouvant inhiber l'activité de CB1 chez un mammifère (par ex., un être humain), ainsi que les méthodes d'utilisation de tels composés pour le traitement de maladies, de troubles et d'états tels que l'obésité, la peur, les troubles métaboliques, le diabète, la dyslipidémie et l'athérosclérose.
Patent WO-2022115376-A1 (WO)
Title: Bolt assembly
Inventor: BALLARD NICK
IPC: F41A3/72
Filed: 2021-11-22
Abstract: A method of assembling a bolt handle to a bolt assembly of a firearm includes inserting the bolt handle through a handle opening defined by a bolt body, A distal end of the bolt handle is inserted through the handle opening until the distal end extends past an outer perimeter of the bolt body. At least a portion of a bolt shroud is inserted through a first portion of an aperture defined by the bolt handle. A force is applied to the bolt shroud while the bolt handle is retracted within the handle opening of the bolt body so that the bolt shroud is positioned within a second portion of the aperture. The bolt shroud is held in connection with the bolt handle when the bolt shroud is positioned within the second portion of the aperture to secure the bolt handle to the bolt body.
Patent WO-2022125430-A1 (WO)
Inventor: SMIDERLE MARK
IPC: A47C21/04
Filed: 2021-12-06
Abstract: Warming devices and related methods are disclosed. The warming devices include a plurality of layers, which include an infrared radiation absorption layer and at least two additional layers, which include an infrared radiation reflection layer and a thermal insulation layer. The infrared radiation absorption layer is configured to absorb at least 50% of incident infrared radiation within the range of 6-18 μm. The infrared radiation reflection layer comprises a reflectivity of at least 0.5 to incident infrared radiation within the range of 6-18 μm. The thermal insulation layer comprises a clo value of at least 0.5 clo. The infrared radiation absorption layer is configured to be more proximate to the user than the at least two additional layers. The infrared radiation reflection is configured to reflect the incident infrared radiation within the range of 6-18 μm in a direction that extends toward the infrared radiation absorption layer and the user.
Patent WO-2023113833-A1 (WO)
Inventor: LUO YAN
IPC: E21B47/10
Filed: 2021-12-21
Abstract: A method of managing an influx encountered during a drilling operation conducted with respect to a wellbore includes drilling a wellbore into a subterranean formation. Drilling the wellbore includes circulating a drilling fluid through a wellbore while operating a drill bit and monitoring one or more parameters associated with the drilling operation for indicia of the influx within the wellbore. The method also includes, upon detecting the indicia of the influx, determining, via an influx management model, an initial influx volume.
Patent WO-2022115830-A1 (WO)
Inventor: CLARKE COLIN
IPC: C02F1/00
Filed: 2021-11-16
Abstract: L'invention concerne un système de gestion d'utilisation d'eau pouvant être installé selon un réglage qui comprend une infrastructure primaire d'utilisation d'eau pour fournir une infrastructure modulaire alternative pour l'utilisation d'eau. L'eau douce utilisée en divers points d'utilisation, telle qu'une douche ou un évier, peut être déviée dans l'infrastructure modulaire avant le drainage dans l'infrastructure primaire. Une fois déviée, l'eau précédemment utilisée est reçue au niveau d'un système de réservoir où elle est traitée pour une utilisation ultérieure. Le traitement peut comprendre une filtration et/ou un traitement chimique, et peut être basé sur une rétroaction de capteur venant du système de réservoir. Une fois traitée, l'eau est prête à être ultérieurement utilisée et peut s'écouler du système de réservoir, par l'intermédiaire de l'infrastructure modulaire, à un point d'utilisation ultérieur, tel qu'une toilette.
Patent WO-2022150639-A1 (WO)
Inventor: ERLEBACHER JONAH D
IPC: B01J19/00
Filed: 2022-01-07
Abstract: A method of producing hydrogen includes subliming a metal salt comprising a metal and a halide to yield a gas phase metal salt comprising the metal and the halide, and contacting the gas phase metal salt with a gas phase hydrocarbon to yield the metal in elemental form, carbon in elemental form, hydrogen gas, and a hydrogen halide comprising the halide.
Patent WO-2022164673-A1 (WO)
Inventor: HORMIS RAJU
IPC: H04B7/08
Filed: 2022-01-18
Abstract: Aspects of the disclosure relate to a node using at least one lens antenna for efficient, effective, and simultaneous multiple beam routing. The node may include a switch matrix communicatively coupling the first antenna with the second antenna. The first antenna may receive and/or transmit one or more directional beams. The second antenna may transmit and/or receive other one or more directional beams. The node may further include a controller configured to control the switch matrix for the coupling. Other aspects, embodiments, and features are also claimed and described.
Patent WO-2022165222-A1 (WO)
Inventor: QUITOVIERA NEIL A
IPC: B01L3/00
Filed: 2022-01-28
Abstract: Des aspects de la présente invention comprennent un bloc tampon permettant de distribuer un tampon pour la préparation d'échantillon à l'aide d'une cartouche de préparation d'échantillon. L'invention concerne également une plaque d'étanchéité configurée pour maintenir le bloc tampon et un capuchon pour actionner le bloc tampon dans la cartouche de préparation d'échantillon. Des aspects de la présente invention comprennent une cartouche de préparation d'échantillon qui comprend le bloc tampon et la plaque d'étanchéité. Des aspects de la présente invention comprennent également une cartouche de préparation d'échantillon qui comprend le bloc tampon, la plaque d'étanchéité et le capuchon. L'invention concerne également des procédés de remplissage du bloc tampon, d'assemblage d'une cartouche destinée à être utilisée dans la préparation d'échantillon, et d'utilisation de la cartouche pour préparer un échantillon.
Patent WO-2022178085-A1 (WO)
Inventor: PARKER BENJAMIN PHILIP
IPC: A01K89/015
Filed: 2022-02-17
Abstract: A fishing reel including a housing, a shaft supported in the housing and configured to rotate relative to the housing around a shaft axis extended in a longitudinal direction of the shaft, and a spool fixed with the shaft to rotate with the shaft around the shaft axis for winding and unwinding a fishing line. The fishing reel also includes a stator fixed with the housing, where the spool is configured to rotate with the shaft relative to the stator and the housing, a stator magnet that is an electromagnet fixed with the stator, a rotor including a first rotor plate fixed with the shaft to rotate with the shaft around the shaft axis, and a first rotor magnet fixed with the first rotor plate. The stator magnet is configured to receive an electrical current and generate a magnetic field from the stator to the first rotor magnet.