baber/WOPTO huggingface dataset:
Patent DE-19843316-C5 (DE)
Title: Kraftübertragungsglied
Inventor: HUBBERT HEINZ-JUERGEN
IPC: F16C11/06
Filed: 1998-09-22
Granted: 2008-05-15
Abstract: Kraftübertragungsglied
bestehend aus einer in einem Kugelkopf (10) endenden Druckstange (9)
und aus einer Kolbenstange (1), die mit einer mit dem Kugelkopf
(10) korrespondierenden Lagerpfanne (4) versehen ist, sowie aus
einer Einrichtung zum Halten des Kugelkopfes (10) in der Lagerpfanne
(4) mit einer hinter dem Kugelkopf (10) koaxial zur Druckstange
(9) in einer Sackbohrung (3) der Kolbenstange (1) angeordneten Hülse (11), wobei
die Hülse
(11) an ihrem der Lagerpfanne (4) zugewandten Ende mit nach innen
gerichteten und nach außen federnd
nachgiebigen Zungen (12) versehen ist, die an eine dem Schaft der
Druckstange (9) zugewandte Fläche (13)
des Kugelkopfes (10) angelegt sind, und wobei der Innendurchmesser
der Hülse
(11) größer ist
als der Durchmesser des Kugelkopfes (10), so dass dieser durch die Hülse (11)
hindurchgeführt
werden kann, dadurch gekennzeichnet, dass die Fläche (13) als schräg zur Achse
der Druckstange (9) verlaufende Ringflächeam hinteren Ende des Kugelkopfes
(10) ausgebildet ist, wobei die...
Patent DE-69825642-C5 (DE)
Title: Andockvorrichtung für ein selbstfahrendes arbeitendes Werkzeug
Inventor: PETERSSON ULF
IPC: A47L9/28
Filed: 1998-12-30
Granted: 2017-07-06
Abstract: nichtig
Patent DE-102008061688-C5 (DE)
Title: Vorsatzoptik für eine Lichtquelle
Inventor: GEBAUER MATTHIAS DR
IPC: F21V3/02
Filed: 2008-12-11
Granted: 2016-12-29
Abstract: Vorsatzoptik (1'') für eine Lichtquelle (5), umfassend einen zentralen Linsenabschnitt (9) mit einer der Lichtquelle (5) zugewandten Lichteintrittsfläche (2) und einer von der Lichtquelle (5) abgewandten Lichtaustrittsfläche (6) und weiter umfassend einen den zentralen Linsenabschnitt (9) umgebenden äußeren Reflexionsabschnitt (10) mit mindestens einer der Lichtquelle (5) zugewandten Lichteinkoppelfläche (3a, 3b), über die von der Lichtquelle (5) ausgesandtes Licht in den Reflexionsabschnitt (10) eintritt, mit mindestens einer von der Lichtquelle (5) abgewandten Lichtauskoppelfläche (7), über die eingekoppeltes Licht aus dem Reflexionsabschnitt (10) austritt, und mit zwischen der mindestens einen Lichteinkoppelfläche (3a, 3b) und der mindestens einen Lichtauskoppelfläche (7) angeordneten Reflexionsflächen (8a, 8b), die in den Reflexionsabschnitt (10) eingekoppeltes Licht reflektieren, wobei die Vorsatzoptik (1'') in einer orthogonal zu einer optischen Achse (4) der Vorsatzoptik (1'') angeordneten Ebene eine größere Längserstreckung als Quererstreckung aufweist, und wobei die Lichteintrittsfläche (2) des zentralen Linsenabschnitts (9) die Form einer Sattelfläche (21) aufweist, wobei die Sattelfläche (21) in Längserstreckung konkav gekrümmt ist, dadurch gekennzeichnet, dass in Richtung der Längserstreckung der Vorsatzoptik (1'') neben der Lichteintrittsfläche (2) des zentralen Linsenabschnitts (9) zusätzliche lichteintrittsseitig optisch wirksame Elemente (17) angeordnet sind, die von der Lichtquelle (5) ausgesandte Lichtstrahlen in einen Bereich einer von der Vorsatzoptik (1'') erzeugten Lichtverteilung lenken, der zwischen dem von dem zentralen Linsenabschnitt (9) ohne die lichteintrittsseitigen optisch wirksamen Elemente (17) ausgeleuchteten Bereich und dem von dem Reflexionsabschnitt (10) ohne die lichteintrittsseitigen optisch wirksamen Elemente (17) ausgeleuchteten Bereich liegt, wobei die lichteintrittsseitig optisch wirksamen Elemente (17) als Fresnellinsen (25) ausgebildet sind.
Patent DE-102014200946-C5 (DE)
Title: Überlast-Überwachungsvorrichtung und Verfahren zur Überlast-Überwachung
Inventor: SCHIEMANN WERNER
IPC: H02H3/08
Filed: 2014-01-20
Granted: 2020-06-10
Abstract: Überlast-Überwachungsvorrichtung für ein elektrisches System (2) mit einer Messeinrichtung (6) für Strom und/oder Spannung, wobei die Überlast-Überwachungsvorrichtung eine Zeitmesseinrichtung (7) und eine mit der Messeinrichtung (6) und der Zeitmesseinrichtung (7) verbundene Auswerteeinrichtung (8) umfasst, die eingerichtet ist, aus Messwerten der Messeinrichtung (6) Kenngrößen zu generieren und anhand der Kenngrößen unter Verwendung von Zeitdaten der Zeitmesseinrichtung (7) eine Überlastsituation zu detektieren, wobei ein mit der Auswerteeinrichtung (8) in Verbindung stehendes Trennelement (5) in einer Zuleitung (3) des elektrischen Systems (2) angeordnet ist, welches von der Auswerteeinrichtung (8) bei einer detektierten Überlastsituation zum Auftrennen der Zuleitung (3) aktivierbar ist, dadurch gekennzeichnet, dass die Kenngröße mindestens einen Wert aus der Gruppe Anstiegsgeschwindigkeit der Leistung und Mittelwert der Leistung umfasst.
Patent RU-2581822-C9 (RU)
Title: Noninvasive bandage
Inventor: Yudanova Tatyana Nikolaevna
IPC: A61P17/02
Filed: 2015-04-03
Granted: 2020-01-28
Abstract: FIELD: medicine. 
     SUBSTANCE: invention relates to production of medical products, in particular noninvasive primarily in contact with wound agents. Disclosed is bandage on textile base, impregnated with composition. Latter is disperse system, in which drug is in aqueous phase, of following composition, wt parts: paraffin 54.0-82.0, Vaseline oil 1-30, water 10.0-15.0, drug 0.01-0.10, glyceryl mono stearate 2-5. Used is paraffin with density of 765 ± 15 kg/m 3 . As medicinal agent can be used antimicrobial agents, local anesthetic agents, proteolytic enzymes. 
     EFFECT: invention provides improved desorption of medicinal agents in wound cavity, which optimizes process of wound healing. 
     3 cl, 1 tbl, 10 ex
Patent RU-2680826-C9 (RU)
Title: Новая соль 3-[(3-{ [4-(4-морфолинилметил)-1н-пиррол-2-ил]метилен} -2-оксо-2,3-дигидро-1н-индол-5-ил)метил]-1,3-тиазолидин-2,4-диона, ее получение и содержащие ее композиции
Inventor: LE-FLOIK Aleksandr
IPC: A61K31/427
Filed: 2014-07-11
Granted: 2019-03-01
Abstract: Изобретение относится к метансульфонату 3-[(3-{[4-(4-морфолинилметил)-1H-пиррол-2-ил]метилен}-2-оксо-2,3-дигидро-1H-индол-5-ил)метил]-1,3-тиазолидин-2,4-диона формулы (II), где обозначениеозначает, что двойная связь имеет конфигурацию Z или Е. Соединение по изобретению, являющееся Z-изомером метансульфоната 3-[(3-{[4-(4-морфолинилметил)-1H-пиррол-2-ил]метилен}-2-оксо-2,3-дигидро-1H-индол-5-ил)метил]-1,3-тиазолидин-2,4-диона, характеризуется рентгеновской порошковой дифрактограммой с углами Брэгга 2 тета (выражаемых в °±0,2) 12,86; 15,13; 15,50; 17,70; 18,25; 18,71; 20,11; 21,46; 21,67; 21,89; 22,29; 22,58; 24,57; 25,82; 26,33. Соединения формулы (II) получают путем применения в качестве исходного материала 3-[(3-{[4-(4-морфолинилметил)-1H-пиррол-2-ил]метилен}-2-оксо-2,3-дигидро-1H-индол-5-ил)метил]-1,3-тиазолидин-2,4-дион, который растворяют в бинарной системе растворителя/воды, а затем добавляют от 1 до 2 молярных эквивалентов метансульфоновой кислоты, перемешивают до выпадения в осадок метансульфоната, который отфильтровывают. Метансульфонат 3-[(3-{[4-(4-морфолинилметил)-1H-пиррол-2-ил]метилен}-2-оксо-2,3-дигидро-1H-индол-5-ил)метил]-1,3-тиазолидин-2,4-диона формулы (II) предназначен для применения в производстве медикаментов для применения в лечении рака и обладает улучшенной растворимостью. 3 н. и 5 з.п. ф-лы, 2 ил., 2 табл., 5 пр.
Patent RU-2670775-C9 (RU)
Title: Терминал, базовая станция, способ передачи и способ приема
Inventor: YAMAMOTO TETSUYA
IPC: H04W72/04
Filed: 2014-06-24
Granted: 2018-12-19
Abstract: Изобретение относится к технологиям сетевой связи. Технический результат заключается в повышении надежности и эффективности сети. Терминал для приема или передачи данных содержит: приемник, который, при эксплуатации, принимает управляющую информацию нисходящей линии связи и данные нисходящей линии связи; схему, которая, при эксплуатации, определяет, на основании управляющей информации нисходящей линии связи и смещения, ресурс канала управления восходящей линии связи, используемый для передачи сигнала ответа для данных нисходящей линии связи; и передатчик, который, при эксплуатации, передает сигнал ответа с использованием определенного ресурса канала управления восходящей линии связи, при этом: первое смещение используется как смещение, когда терминал выполнен в режиме улучшения покрытия, в котором допускается передача сигнала ответа N раз, многократно охватывая множество субкадров, где N – положительное целое число, и первое смещение выполнено для каждого положительного целого значения N; и первое смещение отлично от второго смещения, которое используется, когда терминал не выполнен в режиме улучшения покрытия. 4 н. 18 з.п. ф-лы, 18 ил.
Patent DK-69991-D0 (DK)
Inventor: MOON MALCOLM
IPC: C07D239/10
Filed: 1991-04-18
Abstract: Compounds of formula I <CHEM> have cholinergic agonist or antagonist activity useful in the treatment of mental disorders, extrapyramidal motor disorders, disorders of the parasympathetic nervous system and glaucoma or as analgesics for the treatment of pain. Typical central nervous system disorders for which the subject compounds can be used include cognitive disorders of all ages, including senile dementia, Alzheimer's disease and other related disorders. The compounds are particularly developed to improve mental performance when a mental deficiency is diagnosed.
Patent DK-71291-D0 (DK)
IPC: B28B21/06
Filed: 1991-04-19
Abstract: A slip-form machine serves to cast hollow bodies, in particular pipes of concrete or a similar material, substantially vertically by means of successively progressing zonewise vibration compression. The machine comprises inner and outer slip-form mould parts (9, 10), respectively, which are displaced axially with respect to each other during the casting process. The inner mould part (10) is divided into at least two sections (17, 18) interconnected via one or more elastic spacers, and the uppermost one (17) of these contains at least one vibrator. The natural frequencies of the outer mould part (9) are significantly different from the frequency of the vibrations which are generated by the vibrator. By means of the above-mentioned structure it is now possible to cast e.g. concrete pipes in a faster working cycle, with much smaller investments in moulds, and with a smaller energy consumption than known before. The pipe moreover has a completely uniform quality in the longitudinal direction as well as along the periphery and can be cast with much narrower longitudinal and diameter tolerances than before.
Patent DK-72391-D0 (DK)
Inventor: BISCONTE JEAN-CLAUDE
IPC: B01L3/00
Filed: 1991-04-19
Abstract: PCT No. PCT/FR89/00545 Sec. 371 Date May 31, 1991 Sec. 102(e) Date May 31, 1991 PCT Filed Nov. 20, 1989 PCT Pub. No. WO90/04802 PCT Pub. Date May 3, 1990.A stage (1) for fixing at least one porous or non-porous medium (27) that carries one or more samples to be observed and to be analyzed by means of a microscope. The stage includes a hole (10) for receiving a plate (20; 28) for supporting the medium (27) and thus for observing the samples carried thereby. The stage is designed for pressing the medium (27) against the support plate (20; 28) by suction. The invention is applicable to the biological industry for rapid and indexed analysis under a microscope of filters and other media carrying multiple samples.
Patent DK-172587-D0 (DK)
Inventor: SOUPPE JEROME
IPC: C12P13/00
Filed: 1987-04-03
Abstract: Process of purification of carnitine, in which the aqueous medium containing the carnitine is first acidified, in order to cause the proteins present to precipitate, and, after their separation, the water of the medium is replaced by a lower alcohol which dissolves carnitine, at least hot, while the mineral substances separate out.
Patent DK-231285-D0 (DK)
Inventor: HERRMANN HANS
IPC: B60K23/08
Filed: 1985-05-23
Abstract: A mechanical four wheel drive tractor having a solenoid valve which is de-energized to effect engagement of drive to the front wheels in a predetermined operational mode. Normally, the valve is controlled by an operator switch but when the engine is overloaded and exhaust gas temperature rises, a thermal sensor breaks the circuit to the solenoid valve so that four wheel drive is automatically engaged. This action is restricted to a low gear range by a switch linked to the mechanism selecting between the low range and a high range. Restriction to a low gear range prevents unwanted automatic four wheel drive engagement from occuring in other gear ranges without regard to vehicle speed. Automatic engagement of four wheel drive reduces the overload on the transmission.
Patent DK-393389-D0 (DK)
Inventor: OHLENDORF DIETER
IPC: F15D1/00
Filed: 1989-08-10
Abstract: Mixtures of organic ammonium salts composed of 20 to 80% of a quaternary ammonium salt of the formula   <IMAGE>   and 80 to 20% by weight of an amine salt of the formula   <IMAGE>   where in both formulae R1 denotes C12-C26-alkyl, C12-C26-alkenyl, C12-C26-fluoroalkyl, C12-C26-fluoroalkenyl or a group of the formula   <IMAGE>    <IMAGE>   or  Rf(CH2)yB(CH2)x,  R2 and R3 denote C1-C3-alkyl, preferably methyl, R4 denotes C1-C4-alkyl and, for the case where R1=alkyl or alkenyl, also a group of the formula -(C2H4O)zH, Rf denotes C8-C20-fluoroalkyl or C8-C20-fluoroalkenyl, R5 denotes hydrogen, methyl or ethyl, B denotes oxygen or sulfur, x denotes an integer from 2 to 6, y denotes 0, 1 or 2, and z denotes numbers from 1 to 4, and additionally 30-70 mole %, preferably 40-60 mole %, particularly preferably 50 mol %, of alkali-metal salicylate calculated on the basis of the total amount of  beta -hydroxynaphthoic acid.
Patent DK-442488-D0 (DK)
Inventor: ETZEL MARK R
IPC: B41M5/385
Filed: 1988-08-08
Abstract: A high resolution thermal imaging medium including a support web having an image forming surface of a material which may be temporarily liquified by heat and upon which is deposited a particulate or porous layer of an image forming substance which is wettable by the material during its liquified state.
Patent DK-481387-D0 (DK)
Inventor: NADKARNI SADASHIV K
IPC: C04B35/65
Filed: 1987-09-15
Abstract: Production of composite ceramic articles by infiltration of a particulate, permeable bed or permeable preform with a polycrystalline matrix produced as a metal-oxidant reaction product, wherein the bed or preform is comprised of dross.
Patent DK-494888-D0 (DK)
Inventor: UMIKER HANS
IPC: B65D1/38
Filed: 1988-09-06
Abstract: In a crate, in particular a plastic bottle crate for wine bottles, having side walls and end walls (1, 2 or 3, 4 respectively) and a bottom or bottom grid (5), a structure (6) runs through the interior of the bottle crate, which structure, together with parts of the side walls and end walls (1, 2 and 3, 4 respectively), forms insertion compartments (10) for bottles (11) or similar containers. In this case, elements (26, 31, 32) are to be provided in the insertion compartments (10), on which elements each bottle (11) in each insertion compartment (10) rests with the bottle crate (R) lying on one side wall (1 or 2) with the longitudinal axis (F) of the bottle extending at an angle (v) to said side wall (1 or 2). <IMAGE>
Patent DK-512686-D0 (DK)
Inventor: SILBERING STEVEN B
IPC: A61K47/12
Filed: 1986-10-27
Abstract: A thrombin preparation which has enhanced stability is disclosed. In addition to the thrombin, the preparation comprises a buffer in an amount sufficient to stabilise the thrombin and to buffer the preparation at a pH in the range of from 5.0 to 8.0. The preparation may also include saline and a polyol/polyalkylene polyol. 
<??>A method for making the preparation is also disclosed.
Patent DK-579388-D0 (DK)
Inventor: CASTIGLIONI GIOVANNI PIETRO
IPC: B21D43/09
Filed: 1988-10-18
Abstract: An apparatus for the correct feeding of continuous strips (11) with a shaped side outline to blanking or pressing machines, such as presses, by means of which the continuous strip, unwinding from a roll, can be feed in a position of perfect trueing under the die of the blanking machine, thanks to the presence of a control and of a continuous correction of the positioning errors caused by stresses, or a non-perfect axiality in the fed strip. The strip (11) is fed by a pair of rolls (24,27) one being motor-driven and operatively connected to sensor elements (23) detecting the change in the shaped side outline of the strip.
Patent DK-582987-D0 (DK)
Inventor: REIME GERD
IPC: H04N9/87
Filed: 1987-11-06
Abstract: To reduce the noise signals of a video signal generated at the output (16) of a video head amplifier (3), the frequency response of a video replay head (1) preceding the video head amplifier is lifted by means of the parallel connection of a suitably dimensioned capacitor (10) by a resonant point in the area of the upper frequency limit of the frequency band reproducing the luminance of the video signal and the frequency response of the video head amplifier (3) is lowered in the same frequency band in such a manner that the resultant frequency response of the video replay head (1) and of the video head amplifier (3) is approximately linear up to this upper cut-off frequency and then drops steeply. For lowering the frequency response of the video head amplifier (3), a correspondingly dimensioned frequency-dependent feedback branch (17) from the output (16) of the video head amplifier to its signal input (18) is advantageously used. <IMAGE>
Patent DK-642287-D0 (DK)
Inventor: HANSEN HOLGER CLAUS
IPC: C07D471/14
Filed: 1987-12-08
Abstract: New imidazoquinoxaline compounds having the formula <CHEM>  wherein X is CH, Chalogen or N; and R<3> is <CHEM>  or CO2R min wherein R min  is C1-6 alkyl, C3-7 cycloalkyl or (C1-6 alkoxy)methyl are useful in psychopharmaceutical preparations as anticonvulsants, anxiolytics and hypnotics, and in improving the cognitive function of the brain of mammals.
Patent DK-644889-D0 (DK)
Inventor: GLEASON JOHN GERALD
IPC: C07C323/22
Filed: 1989-12-19
Abstract: Compounds of structure (I) <CHEM> in which, inter alia, R is (CH2)mCO2H, (CH2)mCO2R3, (CH2)mCONHSO2R3, CH2CH(NH2)COR4 or a phenyl(alkyl) or tetrazoyl ring; one of R<1> and R<2> is C8-13alkyl, C7-12alkoxy, phenyl C4-10alkyl or phenyl C4-10alkoxy and the other is H, Br, Cl, CH3, CF3, CF3, OH, NO2 or C1-4alkoxy; R<3> is alkyl, aryl or substituted aryl, R<4> is OH or gly; R<5> is OH, C1-6alkoxy or NHSO2R3; m is 0 to 6; Y is ( @H)n(CH2)pCONHSO2R3, ( @H)n(CH2)p-T,    ( @H)n(CH2)pCO2H   or (CH)n(CH2)pCOR3, where T is tetrazoyl; A is H, OH, alkyl alkoxy OAc or F, n is 0 of 1 and p is 0 or 1; processes for their preparation, compositions containing them and their use in therapy as leukotriene antagonists.
Patent HU-912408-D0 (HU)
Title: Process for producing o-methyl derivatives of azithromycine a and pharmaceutical preparatives containing said compounds
Inventor: KOBREHEL GABRIJELA
IPC: A61K31/7042
Filed: 1991-07-18
Abstract: Derivs. of azithromycin A of formula (I) and salts are new. (Ia) : R1 = R2 = CO2CH2C6H5; R3 = CH3; R4 = R5 = H; (Ib) : R1 = R2 = CO2CH2C6H5; R3 = R4 = CH3; R5 = H; (Ic) : R1 = R2 = CO2CH2C6H5; R3 = R5 = H; R4 = CH3; (Id) : R1 = R2 = CO2CH2C6H5; R3 = R4 = R5 = CH3; (Ie) : R1 = R2 = R4 = R5 = H; R3 = CH3; (If) : R1 = R2 = R5 = H; R3 = R5 = CH3; (Ig) : R1 = R2 = R5 = H; R4 = CH3; (Ih) : R1 = R2 = H; R3 = R4 = R5 = CH3; (Ii) : R1 = R4 = R5 = H; R2 = R3 = CH3; (Ij) : R1 = R5 = H; R2 = R3 = R4 = CH3; (Ik) : R1 = R3 = R5 = H; R2 = R4 = CH3; (Il) : R1 = H; R2 = R3 = R4 = R5 = CH3.
Patent HU-912455-D0 (HU)
Title: Lubricants
Inventor: CARTER BEIAN HOWELL
IPC: C10M105/32
Filed: 1991-07-22
Abstract: The use of mixtures of 1,1,1,2-tetrafluoroethane and an ester having a molecular weight of greater than 250 as retrofill working fluid/lubricant combinations for mechanical vapor recompression heat transfer devices. Despite the presence of residual lubricant, e.g. hydrocarbon lubricants, from working fluid/lubricant combinations in which working fluids such as R12, R22, R502 or R511 are used, anticipated problems resulting from immiscibility such as excessive wear have not been observed.
Patent HU-894041-D0 (HU)
Title: Phase control circuit
Inventor: STORZ DIETER
IPC: G11B19/28
Filed: 1989-05-26
Abstract: PCT No. PCT/EP89/00590 Sec. 371 Date Feb. 12, 1990 Sec. 102(e) Date Feb. 12, 1990 PCT Filed May 26, 1989 PCT Pub. No. WO89/12932 PCT Pub. Date Dec. 18, 1989.A phase control circuit in which a first phase comparator compares an input frequency with a reference frequency. The output of the first phase comparator is connected to a controlled oscillator through a control stage. A second control stage is also connected to the input of the controlled oscillator which has an output connected to a second phase comparator which receives also the reference frequency at an input. The output of the second phase comparator is connected to an input of the second control stage. The first control stage is separated from the controlled oscillator to compensate the circuit automatically. The second control stage varies its output until the frequency at the controlled oscillator output equals the reference frequency. The second control stage maintains this level subsequent to compensation independent of the output from the second phase comparator, and the first control stage is reconnected to the input terminal of the controlled oscillator.
Patent IT-8903446-D0 (IT)
Inventor: TREVISANI DAVIDE
IPC: E21C25/22
Filed: 1989-04-28
Abstract: The method for boring a tunnel consists in placing an excavation tool (6) at a point of the extrados of the tunnel and in excavating a cavity (13) by imparting the tool an advancement movement having divergent direction with respect to the axis (A) of the tunnel. While the cavity is being filled with concrete, a further cavity is excavated in another point of the extrados and is then also filled with concrete. These operations are repeated until a plurality of voussoirs (14) is obtained which are arranged adjacent to one another along the extrados and give rise to a frustum-shaped vault (15). The soil inside the vault is then excavated for a depth which is smaller than the axial extension of the vault itself, and a subsequent vault (15 min ) is formed having a narrower initial portion internal to the wider terminal portion of the previously executed vault (15).
Patent NO-863493-D0 (NO)
Inventor: BORGHI ANGELO
IPC: G01N33/545
Filed: 1986-09-01
Abstract: The present invention relates to a method for determining a substance capable of actual binding to a D-Alanyl-D-Alanine dipeptide, in particular the glycopeptidic antibiotics of the vancomycin class and their derivatives and aglycons and to an antibody raised against the substance. Further objects of the present invention are compositions of matter (kits) and means for exploiting the method of the invention.
Patent NO-910902-D0 (NO)
Inventor: KACIAN DANIEL LOUIS
IPC: C12Q/
Filed: 1991-03-07
Abstract: Oligonucleotide probes for HIV nucleic acid are disclosed. Also disclosed are: methods of synthesizing multiple copies of a target nucleic acid sequence autocatalytically under conditions of substantially constant temperature, ionic strength, and pH are provided in which multiple RNA copies of the target sequence autocatalytically generate additional copies. These methods are useful for generating copies of a nucleic acid target sequence for purposes which include assays to quantitate specific nucleic acid sequences in clinical, environmental, forensic and similar samples, cloning and generating probes.