baber/WOPTO huggingface dataset:
Patent CA-2761696-A1 (CA)
Inventor: LI MEI
IPC: C07K16/18
Filed: 2010-05-10
Abstract: The present invention provides antibodies and fragments thereof that bind to Dkk-1 and, in particular, to humanized antibodies and fragments thereof that bind to Dkk-1 and, even more particularly to fully humanized antibodies and immunologically functional fragments that bind to Dkk-1. Also provided are antibodies and fragments thereof which compete with the binding of an anti-mouse Dkk-1 monoclonal antibody for binding to Dkk-1+  cells. Also provided are nucleic acids encoding anti-Dkk-1 antibodies or fragments thereof, as well as expression vectors and host cells incorporating these nucleic acids for the recombinant expression of anti-Dkk-1 antibodies and fragments thereof. Also provided are methods of preparing the antibodies and fragments thereof of the invention. Also provided are bone anabolic agents.  Pharmaceutical compositions comprising the antibodies or fragments thereof of the invention are also provided. Further provided are methods of treating diseases, conditions and disorders, such as bone disorders, which result in a loss of bone. Methods of treating or preventing a loss of bone mass, methods of inducing increased bone mass, and methods of inducing Wnt activity are also provided.
Patent CA-2762174-A1 (CA)
Inventor: RODGERS JAMES D
IPC: C07D487/04
Filed: 2010-05-21
Abstract: The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of Formula (I): which are JAK inhibitors, such as selective JAK1 inhibitors, useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.
Patent CA-2765109-A1 (CA)
Title: Folder notebooks
Inventor: SADA DENISE E
IPC: B42F13/00
Filed: 2010-06-22
Abstract: A bound component has a front cover attached to a spine attached to a rear cover, a binding mechanism, and a binder extension attached to either cover. The binder extension folds inwardly in its closed position and has pockets. Also disclosed is a bound component having a front cover attached to a spine attached to a rear cover, a binding mechanism and one or more pockets attached to either cover. The pocket may have one or more closure flaps and may be expandable. Also disclosed is a folder having one or more bound edges and one or more free edges, one or more folder tabs extending from one or more free edges, and a plurality of pages bound to the folder. The pages may be bound to the folder using adhesive, string, staples or other attachment mechanisms. The folder may fit within a traditional file drawer.
Patent CA-2765823-A1 (CA)
Title: Tricyclic heterocyclic compounds as mediators of p13k activity
Inventor: CUSHING TIMOTHY D
IPC: C07D407/14
Filed: 2010-06-25
Abstract: Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia ( T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.
Patent CA-2766505-A1 (CA)
Inventor: JAKOBSEN BENT KARSTEN
IPC: C07K14/705
Filed: 2010-07-01
Abstract: A T cell receptor (TCR) having the property of binding to the gp100 YLEPGPVTA peptide-HLA-A2 complex and comprising a TCR alpha variable domain and/or a TCR beta variable domain, characterized in that: (i) said TCR is mutated relative to a TCR having the extracellular alpha and beta chain sequences SEQ ID Nos: 2 and 3 in its alpha chain variable domain amino acids 1 to 109 of SEQ ID No: 2 and/or its beta chain variable domain amino acids 1 to 112 of SEQ ID No: 3; and (ii) said alpha variable domain has at least 90% sequence identity to the amino acid sequence 1 to 109 of SEQ ID No: 2, and/or said beta variable domain has at least 90% sequence identity to the amino acid sequence 1 to 1 12 of SEQ ID No: 3; and (iii) said TCR has a binding affinity for, and/or a binding half-life for, the YLEPGPVTA-HLA-A2 complex at least double that of a reference TCR, the said reference TCR having the extracellular alpha chain sequence SEQ ID No: 45 and the extracellular beta chain sequence SEQ ID No: 46. The use of such TCRs in adoptive therapy, and fusions of such TCRs with therapeutic agents are also described.
Patent CA-2769832-A1 (CA)
Title: Dental apparatus
Inventor: MAYCHER DAVID JOHN
IPC: A61C17/06
Filed: 2010-08-04
Abstract: A dental apparatus for removing fluid from a patient's mouth during a dental procedure, the dental apparatus includes an intraoral tip having a wall defining a cavity, the wall having a plurality of apertures and at least one opening, the apertures being distributed over the wall; and a hollow tube coupled to the intraoral tip, the hollow tube for connecting the opening of the intraoral tip to a suction device. The intraoral tip is continuously within the patient's mouth during the dental procedure and the dental apparatus removes fluid from the patient's mouth through the apertures of said intraoral tip. In one embodiment, the dental apparatus further includes a valve for modulating the rate of fluid removal from the patient's mouth. In another embodiment, the dental apparatus further includes a fastener for securing the intraoral tip within the patient's mouth.
Patent CA-2771651-A1 (CA)
Inventor: PORTILLO SALIDO ENRIQUE
IPC: A61K31/135
Filed: 2010-10-15
Abstract: The present invention relates to pharmaceutical compositions comprising tramadol and celecoxib and their uses as medicaments or analgesics, more particularly for the treatment of severe to moderate pain with an inflammation component.
Patent CA-2773379-A1 (CA)
Title: Method and apparatus for conversion of multiple analyte cation types to a single analyte anion type via ion/ion charge inversion
Inventor: HASSELL KERRY MARIE
IPC: G01N30/72
Filed: 2010-09-07
Abstract: An apparatus and method for a sample using a mass spectrometer is described, including, generating ions of a first polarity from an analyte using electrospray ionization; generating ions of a second polarity from a reagent; injecting the ions of the first polarity and ions of the second polarity in sequence into a chamber of the mass spectrometer such that the ions of the first polarity and the ions of the second polarity interact in the chamber to form analyte ions having the second polarity; and, analyzing the mass spectrum of the analyte ions of the second polarity. A reagent such as a polyamidomine is selected to preferentially yield analyte ions of the second polarity having a desired mass-to-charge ratio.
Patent CA-2773665-A1 (CA)
Title: Exotoxine a pseudomonias amelioree a immunogenicite reduite
Inventor: PASTAN IRA H
IPC: A61K47/48
Filed: 2010-09-10
Abstract: La présente invention concerne des molécules d'Exotoxine A de Pseudomonas présentant une cytotoxicité élevée et une immunogénicité réduite, des compositions contenant ladite d'Exotoxine A de Pseudomonas améliorée, et des procédés d'utilisation.
Patent CA-2773886-A1 (CA)
Inventor: HUNG GENE
IPC: C07H21/04
Filed: 2010-09-10
Abstract: Provided herein are methods, compounds, and compositions for reducing expression of huntingtin mRNA and protein in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate Huntington's disease, or a symptom thereof.
Patent CA-2775360-A1 (CA)
Title: Planetary gear retrieval system
Inventor: JEDNEAK ALLAN RAY
IPC: F16H7/18
Filed: 2012-04-24
Abstract: A planetary gear retrieval system for pulling a sled at a constant velocity along an interior of a pipe. The system includes a network of gears, one of the gears powered by a gear motor, which is in operable communication with a variable speed microcontroller. A chain is threaded through the network of gears and an end of the chain is connected to the sled.
Patent CA-2776883-A1 (CA)
Title: Antimicrobial and antibiofilm activity of cathelicidins
Inventor: DE LATOUR FRANK
IPC: A61P1/02
Filed: 2010-06-16
Abstract: The present disclosure relates to peptides, and fragments thereof, conferring antimicrobial and/or antibiofilm growth, as well as products and methodology for using same.
Patent CA-2777859-A1 (CA)
Inventor: BANERJEE DWIJEN K
IPC: E21B43/24
Filed: 2012-05-22
Abstract: A process for utilizing microwaves to heat solvent within a subterranean region wherein the heated solvent, vapor, contacts heavy oil in the subterranean region to lower the viscosity of the heavy oil and improve production of the heavy oil.
Patent CA-2784412-A1 (CA)
Inventor: MAESAKA MASAYUKI
IPC: C08K7/24
Filed: 2010-12-14
Abstract: Pneumatique hiver à adhérence améliorée sur glace fondante, dont la bande de roulement comporte une composition comportant au moins un élastomère diénique tel que du caoutchouc naturel et/ou un polybutadiène, plus de 30 pce d'un agent plastifiant liquide, entre 50 et 150 pce d'une charge renforçante telle que silice et/ou noir de carbone, et 35 à 50 pce de microparticules creuses d'au moins un oxyde métallique tel qu'un aluminosilicate, ayant une taille médiane en poids comprise entre 2 et 500 µm.
Patent CA-2784493-A1 (CA)
Title: Elastomeric plow edge
Inventor: WINTER KENT
IPC: A01B15/02
Filed: 2012-08-03
Abstract: A plow edge having improved durability and performance is provided which can comprise an elastomeric material, for example, a styrene elastomeric material. The present disclosure provides a plow blade edge system for mounting to a mold board of a plow comprising an adapter blade, at least two elastomeric blade segments wherein each segment is selectively reversible to present first and second edges; a clamp bar wherein the clamp bar is mounted to the adapter blade with the at least two elastomeric blade segments secured therebetween; and, each of the at least two elastomeric blade segments secured selectively in a first position or a second position.
Patent CA-2784596-A1 (CA)
Inventor: ANNES JUSTIN P
IPC: A61P3/10
Filed: 2010-12-17
Abstract: In the invention provides for a method of stimulating or increasing ß-cell replication or growth, by contacting a ß-cell with an inhibitor of adenosine kinase (ADK), an inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) or an activator of AMP activated protein kinase (AMPK).
Patent CA-2784885-A1 (CA)
Title: Seismic clip
Inventor: TEDESCO LEE M
IPC: E04B9/30
Filed: 2010-12-20
Abstract: A seismic clip for suspended ceiling grid tees that offers high strength, rigidity, versatility and ease of assembly while improving the ability of a clip to self-align with a grid tee. The clip includes a lanced tab that serves to establish and maintain alignment of the clip body and the tee to which it is assembled whereby a tendency of a clip to be tilted upwardly relative to the tee is eliminated or greatly reduced. The alignment tab serves to initially align the clip and tee either when it is assembled by snapping it over the tee or by sliding the tee endwise into the clip. The tab is configured so that it does not unduly add to the assembly force level when the clip is snapped over the tee or when the tee and clip are slipped endwise together.
Patent CA-2785313-A1 (CA)
Inventor: ES ANTON VAN
IPC: E04H17/14
Filed: 2012-08-14
Abstract: A fence rail and picket assembly includes a retainer for joining a picket upright to a fence rail. The retainer includes a forward portion including locking heads and a tongue portion. A picket upright formed of sheet material including rear flanges and defining a retainer cavity for receiving the forward portion of the retainer therein. The picket upright includes apertures along rear flanges for receiving the retainer heads there through. A fence rail receives the tongue portion of the retainer there on for operably securing the tongue to the rail.
Patent CA-2785632-A1 (CA)
Inventor: HUGHES BARRY J
IPC: B25B23/00
Filed: 2010-09-15
Abstract: Various embodiments described herein provide a fastener system having straight walled driving surfaces that provides a reliable stick fit feature, while also improving stability of engagement between the system components. A feature of the new system is to allow engagement of existing standard straight walled drivers in the new system.
Patent CA-2787900-A1 (CA)
Title: Quantitative analysis of vitamin d3, vitamin d2, and metabolites thereof
Inventor: DEY SUBHAKAR
IPC: A61K31/59
Filed: 2011-01-25
Abstract: Quantification of vitamin D2, vitamin D3, and the monohydroxy and diihydroxy metabolites of vitamin D2 and vitamin D3, can comprise labeling analytes with mass spectrometry (MS) tagging reagents and performing LC-MSMS analysis of the labeled analytes. The labeled analytes can include a labeled standard and can have distinct retention times on a reversed phase column, as well as distinct masses. Under high energy collisions, reporter groups can be generated. The intensity or the peak area detected for each reporter group can be used for quantitation. In some embodiments, a one-step tagging reagent is used that is a dienophile-containing, labeled Diels Alder reagent.
Patent CA-2788256-A1 (CA)
Title: Apparatus including powered tool configured to fasten fastener to assembly
Inventor: MACARTHUR BENJAMIN
IPC: B23P19/06
Filed: 2012-08-31
Abstract: An apparatus includes a powered tool configured to fasten a fastener to an assembly.  The powered tool includes a fastener-driving assembly configured to selectively operatively engage the fastener. The fastener-driving assembly is also configured to selectively transmit a fastening force to the fastener. The powered tool also includes a fastener-engagement assembly configured to permit operative engageable access between the fastener-driving assembly and the fastener. For a case where the fastener-engagement assembly permits operative engageable access between the fastener-driving assembly and the fastener, the fastener-driving assembly may operatively engage the fastener, and the fastener-driving assembly may transmit the fastening force to the fastener.
Patent CA-2788394-A1 (CA)
Inventor: BENN CHRISTOPHER CHARLES
IPC: A61B18/14
Filed: 2011-01-21
Abstract: An electrosurgical instrument is provided for the treatment of tissue, the instrument comprising an instrument shaft (10) having a longitudinal axis, and an electrode assembly at one end of the shaft. The electrode assembly comprises first and second active electrodes (11, 14) and at least one return electrode (25). The first and second active electrodes (11, 14) each have an exposed surface to treat tissue disposed laterally of the longitudinal axis at a first radial an a second radial position with respect to the instrument shaft. The instrument has a first set of connections by which the first active electrode (11) can be placed in circuit with the return electrode (25), and a second set of connections by which the second active electrode (14) can be placed in circuit with the return electrode (25).
Patent CA-2790030-A1 (CA)
Inventor: MISTRY NIMISHA
IPC: A23F5/24
Filed: 2012-09-14
Abstract: The present invention provides a coffee filter pod containing roast and ground coffee, wherein the roast and ground coffee has a plurimodal volume distribution density with a first peak of from 30 to 60 microns and a second peak of from 260 to microns, wherein the ratio of the volume of the particles in the first peak relative to the volume of the particles in the second peak is from 2:1 to 1:2.
Patent CA-2790564-A1 (CA)
Inventor: SMITH MERRILL BROOKS
IPC: G06Q20/00
Filed: 2010-12-20
Abstract: The invention is generally directed to a method of managing the activation and use of a specific merchandise, facilitated between at least a retailer that sells the specific merchandise, a customer that purchases the specific merchandise, and a central processor that authorizes activation and use of the specific merchandise. The method includes the steps of receiving an indicia that uniquely identifies the specific merchandise, and an activation code associated with the merchandise that will allow the merchandise to properly function, storing the indicia of the specific merchandise and the activation code, receiving a confirmation of a valid purchase transaction of the specific merchandise, the confirmation of valid sale comprising the indicia of the specific merchandise, determining the activation code associated with the specific merchandise, and providing the activation code associated with the specific merchandise to the customer.
Patent CA-2790767-A1 (CA)
Title: Bldc motor for a hair dryer
Inventor: KWON HYUK TAE
IPC: H02K7/14
Filed: 2010-03-15
Abstract: The present invention relates to a BLDC motor for a hairdryer, and particularly, to a BLDC motor for a hairdryer comprising high-strength integrated injection-molded components so as to reduce the number of components, reduce manufacturing costs, and achieve a lighter weight, and applying a coupling method in which a sirocco fan mounted onto the motor is coupled directly to the outer periphery of a rotor housing so as to optimize the coupling structure of the fan to achieve a stable rotating operation, remove unwanted vibrations and noise generated from rotation, and maximize the inflow of air. To achieve these aims, the BLDC motor of the present invention comprises: a rotor housing including a plurality of permanent magnets on the inner surface thereof, and in the center of which a shaft hole is defined through which a shaft is inserted, and having a sirocco fan for generating airflow coupled to the outside thereof; a rotor frame for connecting and coupling the shaft to the rotor housing such that the shaft and the rotor housing rotate together; a stator core having a coil wound thereon to generate rotational force by means of the interaction with magnetic fields formed by the permanent magnets; a PCB substrate coupled to the lower portion of the stator core by means of screws; a base bracket having a supporting ledge formed at the upper outer portion thereof to support the stator core; and a bearing housing coupled to an upper portion of the base bracket to support a ball bearing, and including an anti-disengagement ledge at the lower outside portion thereof to prevent the disengagement of the stator core.
Patent CA-2791825-A1 (CA)
Inventor: MIKKELSEN RENE
IPC: C12Q1/44
Filed: 2011-04-06
Abstract: The present invention provides a method for detecting a phytol-free chlorophyll derivative in a sample, comprising a step of detecting a fluorescent signal associated with the phytol-free chlorophyll derivative, wherein a fluorescent signal associated with chlorophyll or a phytol-containing chlorophyll derivative in the sample is quenched. The method may be used for quantifying activity of chlorophyllases and related enzymes in a sample without solvent fractionation of substrate and product.
Patent CA-2792731-A1 (CA)
Title: Fuel cell system with multiple cooling circuits
Inventor: CHERCHI PIERPAOLO
IPC: H01M8/18
Filed: 2011-03-15
Abstract: The invention relates to an electric power generator (1) comprising a plurality of fuel cells stacked in a stack (5) and configured to supply an electric load (6), the generator (1) comprising means (2) for generating a gas fuel to be supplied to the stack (5), and means (7, 10) for removing at least part of a heat flow generated in the stack (5) as a consequence of the consumption of said, gas fuel; characterized in that it comprises heating means (8, 9) configured to maintain said means (2) for generating gas fuel within a predetermined temperature range and comprising means (9) for transferring at least part of said removed part of the heat flow generated in the stack (5) from said removing means (7) to said means (2) for generating gas fuel.
Patent CA-2793497-A1 (CA)
Inventor: WATKISS JASON
IPC: F01D25/00
Filed: 2012-10-29
Abstract: A gas turbine engine has an electrical harness formed from a flexible printed circuit board which provides a plurality of spaced conductive tracks. The conductive tracks are grouped into plural layers of tracks, the track layers being spaced apart and extending substantially parallel to each other. The tracks of each track layer form respective circuits which all have impedances lying within a respective range for that track layer. The impedances ranges are non-overlapping. The highest voltage differentials between tracks produced during indirect lightning strikes will thus tend to be between tracks of different track layers rather than between tracks of the same track layer.
Patent CA-2795328-A1 (CA)
Inventor: HOFMANN THOMAS
IPC: F21V15/01
Filed: 2011-04-04
Abstract: The invention relates to a lamp housing (100, 200, 300, 400, 500) having an upper region and a lower region as well as a channel (110, 210, 310, 410, 415, 510), wherein in the upper region the channel is connected to an air outlet opening (120, 220, 225, 320, 325, 420, 425) and in the lower region the channel is connected to an air inlet opening (130, 230, 330, 430, 435, 530), and wherein the lamp housing further comprises a receiving chamber for a lighting module (250, 550) which is disposed so that in the installed state the lighting module is located on the channel.
Patent CA-2797577-A1 (CA)
Inventor: PANOZZO TONY
IPC: A47C7/18
Filed: 2011-04-26
Abstract: An improved attachment structure is provided for securing a cover (22) in overlying covering relation to a seat cushion (25). In the chair, the chair comprises a seat/back assembly (14) having a seat assembly (17) and back assembly (16) which are supported upon a load-bearing base adapted for support upon a floor. The attachment structure provides an improved method of securing a cover (27) about its peripheral edge to an outer (40) and inner (32) shell on a seat assembly (17), wherein cooperating rib(50)s and channel sections form convolutions in the fabric edge and hold the fabric edge between the inner and outer shells.
Patent CA-2800879-A1 (CA)
Inventor: MOSTOWFI FARSHID
IPC: G01N21/35
Filed: 2011-04-30
Abstract: A system for determining the asphaltene content of crude oil includes a first opticai flow cell, a first spectrometer operably associated with the first optical flow cell, and a mixer in fluid communication with the first optical flow cell. The system further includes a crude oil injection/metering device configured to receive the crude oil, the crude oil injection/metering device being in fluid communication with the first optical flow cell; a titrant injection/metering device in fluid communication with the mixer, the titrant injection/metering device configured to receive a titrant; and a filtration unit in fluid communication with the mixer. The system further includes a second optical flow cell in fluid communication with the filtration unit, and a second spectrometer operably associated with the second optical flow ceil.