Patent GB-696912-A (GB)
Title: Germicidal complex compounds and preparations containing them
IPC: C07F1/00
Filed: 1951-01-26
Abstract: The invention comprises a water-soluble complex of a mono-alkylol amine and a silver salt, the empirical formula of which corresponds to one equivalent of the silver salt to at least two molecular proportions of the alkylol amine and comprises the preparation thereof by dissolving a silver salt in a substantially anhydrous monohydroxy - monoamino - alkane, preferably maintaining the liquid at 10-50 DEG  C. for at least five minutes. Suitable alkylolamines are mono-ethanolamine, b -hydroxy isopropylamine, b -amino-n-propanol and monobutylolamine. Suitable silver salts are the chloride, bromide iodide, acetate, lactate, benzoate, nitrate, succinate, phosphate and sulphate. The products are used as germicides.  The preparation of the complexes between monoethanolamine and silver chloride, bromide, iodide, nitrate, sulphate, phosphate, acetate and lactate is described in examples.ALSO:In the manufacture of germicidal soap compositions, use is made of solutions obtained by dissolving a silver salt in a substantially anhydrous monohydroxy-monoamino-alkane (see Groups IV(b) and VI) and diluting with water to form a clear solution.  A water insoluble silver compound is precipitated when the solution is treated with an acid or salt.  In an example, powdered talc is treated with a solution of silver chloride in ethanolamine, washed with aqueous sodium chloride, filtered, washed with water and dried, and is then incorporated into a soap powder.  Also a soap is made by reacting stearic acid with a solution of silver chloride in excess ethanolamine.ALSO:The invention comprises aqueous germicidal solutions obtained by dissolving a silver salt in a substantially anhydrous monohydroxy-monoamino-alkane, preferably maintaining the liquid at 10-50 DEG  C. for at least five minutes to produce a water soluble complex (see Group IV (b)) and diluting with water to form a clear solution.  It comprises also a method of rendering articles self sterilizing by wetting with the aqueous germicidal solution and subsequently precipitating a water-insoluble silver compound by diluting the solution, or by treating the solution with an acid or salt.  In examples, germicidal solutions comprising complexes of monoethanolamine with silver chloride, bromide, iodide, nitrate, lactate, sulphate, phosphate and acetate are described; (1) surgical gauze treated with an aqueous solution of a silver chloride-monoethanolamine complex is washed with water, bleached with sodium hypochlorite, rinsed and dried and is found to be sterile and antiseptic; (2) a herringbone twill cloth is treated by the method of (1); (6) powdered calcium carbonate is treated with an aqueous solution of a silver chloride-monoethanolamine complex, aqueous sodium chloride is added, the mixture is filtered and washed with water and the dried product is incorporated into a toothpaste; (7) powdered magnesium oxide is used in place of calcium carbonate in (6); (8) talc treated by the method of (6) is used in the preparation of face powder; (9) diaper cloth is treated as in (1); and (12) zinc oxide treated as in (6) is mixed with phosphoric acid and aluminium phosphate to give a sterile and antiseptic dental filling.