Patent SG-11201810947P-A (SG)
Title: Compositions and methods for the treatment of cancer
Inventor: KANDULA MAHESH
IPC: A61K31/505
Filed: 2017-05-12
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 04 January 2018 (04.01.2018) W I PO I PCT omit VIII °nolo III IIIII 110101001110111 110111110m oimIE (10) International Publication Number WO 2018/002739 Al (51) International Patent Classification: A61K 31/505 (2006.01) C07H 19/06 (2006.01) A61K 31/506 (2006.01) CO7H 19/067 (2006.01) A61P 31/00 (2006.01) (21) International Application Number: PCT/IB2017/052814 (22) International Filing Date: 12 May 2017 (12.05.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 201641022026 28 June 2016 (28.06.2016) IN 201641025259 22 July 2016 (22.07.2016) IN 201741006185 21 February 2017 (21.02.2017) IN (71) Applicant: CELLIX BIO PRIVATE LIMITED [IN/IN]; Plot No. 1177 B, Road No. 56, Jubilee Hills, Hyderabad 500 033 (IN). (72) Inventor: KANDULA, Mahesh; 11-61, G.MEDAPADU, Andhra Pradesh 533434 (IN). (74) Agent: BHATTACHARYYA, Goutam et al.; K&S Part- ners, 101, Ivy Terrace, Plot No-119, Kavuri Hills, Road no-44, Madhapur, Hyderabad 500 033 (IN). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) - before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) 1-1 t:T N N O O GC O 1-1 N C (54) Title: COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER (57) : The invention relates to the compounds or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoiso- mers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II, formula III, formula IV, formula V, formula VI, formula VII and formula VIII and, the methods for the treatment of cancer and infec- tious diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, lozenge, spray, intravenous, oral solution, buccal mucosal layer tablet, parenteral administration, syrup, or injection. Such compositions may be used to treatment of cancer, neo- plasm, infections and skin diseases.