Patent SG-11201810697Q-A (SG)
Title: Chimeric antigen receptor and car-t cells that bind bcma
Inventor: REHM ARMIN
IPC: C07K16/28
Filed: 2017-06-07
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111111111111111111111111111111111111111111111111111111111111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\"\" WO 2017/211900 Al 14 December 2017 (14.12.2017) WIP0 I PCT (51) International Patent Classification: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, A61K 35/17 (2015.01) C07K 16/28 (2006.01) MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, (21) International Application Number: TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, PCT/EP2017/063862 KM, ML, MR, NE, SN, TD, TG). (22) International Filing Date: Published: 07 June 2017 (07.06.2017) — with international search report (Art. 21(3)) — (25) Filing Language: English with sequence listing part of description (Rule 5.2(a)) (26) Publication Language: English (30) Priority Data: 16173401.7 07 June 2016 (07.06.2016) EP (71) Applicants: MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZIN [DE/DE]; Robert- Rossle-Str. 10, 13125 Berlin (DE). HUM- BOLDT-UNIVERSITAT ZU BERLIN [DE/DE]; Unter den Linden 6, 10099 Berlin (DE). (72) Inventors: REHM, Armin; Suarerstr. 41, 14057 Berlin (DE). HOPKEN, Uta Elisabeth; SuarerstraBe 41, 14057 Berlin (DE). BLUHM, Julia; HilbnerstraBe 4, 10247 Berlin (DE). UCKERT, Wolfgang; StraBe 45, Nr. 28, 13125 Berlin (DE). KIEBACK, Elisa; Winsstr. 61, 10405 Berlin (DE). MARINO, Stephen; Katzbachstrasse 3, 10965 Berlin (DE). (74) Agent: HERTIN UND PARTNER RECHTS- UND PATENTANWALTE PARTG MBB; Kurftirstendamm 54/55, 10707 Berlin (DE). (81) Designated States (unless otherwise indicated, for every — kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every = kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 1-1 C (54) Title: CHIMERIC ANTIGEN RECEPTOR AND CAR-T CELLS THAT BIND BCMA c : N (57) : The invention relates to an isolated chimeric antigen receptor polypeptide (CAR), wherein the CAR comprises an 1-1 extracellular antigen-binding domain, comprising an antibody or antibody fragment that binds a B Cell Maturation Antigen (BCMA) N polypeptide. The CAR preferably binds an epitope comprising one or more amino acids of residues 13 to 32 of the N-terminus of human ---. BCMA. The invention further relates to a nucleic acid molecule encoding the CAR of the invention, a genetically modified immune I N cell ' preferably a T cell, expressing the CAR of the invention and the use of said cell in the treatment of a medical disorder associated 1-1 c;;;;) with the presence of pathogenic B cells, such as a disease of plasma cells, memory B cells and/or mature B cells, in particular multiple ei myeloma, non-Hodgkin's lymphoma or autoantibody- dependent autoimmune diseases. C