Patent EP-2674162-A1 (EP)
Inventor: KRUSZEWSKA DANUTA
IPC: A61K35/747
Filed: 2013-05-29
Abstract: The invention relates to a use of  Lactobacillus reuteri  DAN080 strain with deposit number DSM 15693 as an active component for manufacturing a dermaceutic effective in skin infections in vertebrate, in particular human being, other mammal or bird, and for manufacturing a medical device in the form of a dressing or hygienic materials for use in a wound care and personal hygiene - respectively, to avoid skin infections in vertebrate, in particular human being, other mammal or bird, as well as for manufacturing a medical device in the form of plastic protector sheet and fire-blankets intended for rescue units, including fire-brigades, specifically for patients with extensive skin bums and for victims of communication accidents with serious body surface injuries, to avoid skin infections in vertebrate, in particular human being, other mammal or bird. 
     The  Lactobacillus reuteri  DAN080 strain with deposit number DSM 15693 is used in form of the  L. reuteri  DAN080 strain culture, partially inactivated  L. reuteri  DAN080 strain culture; liquid supernatant of  L. reuteri  DAN080 strain culture, concentrated supernatant of  L. reuteri  DAN080 strain culture and dried supernatant of  L. reuteri  DAN080 strain culture for prophylaxis and treatment of medical conditions developing as a result of infections caused by bacteria, fungi, and other pathogens of the body surface in vertebrate, and alternatively in form selected from the group comprising the whole  L .  reuteri  DAN080 strain culture; liquid, concentrated and dried supernatants obtained from  L. reuteri  DAN080 strain cultures and from mixed bacterial cultures containing  L. reuteri  DAN080 strain and liquid, concentrated and dried supernatants obtained from the cultures of prokaryotic and eukaryotic recombinants, and the whole cultures of prokaryotic and eukaryotic recombinants, in which and/or from which genes are utilized, which genes provide specific modulatory, inhibitory, and homeostatic activity with respect to  H. pylori  and other bacteria; proteins/oligopeptides/peptides of molecular weight of approximately: 150 and/or 141 and/or 115 and/or 95 and/or 90 and/or 86 and/or 83 and/or 77 and/or 71 and/or 63 and/or 59 and/or 56 and/or 49 and/or 46 and/or 43 and/or 39 and/or 34 and/or 32 and/or 30 and/or 22 kD and lower, purified/isolated from liquid/concentrated/dried supernatant obtained from  L. reuteri  DAN080 strain [cultures] and purified/isolated from the whole  L. reuteri  DAN080 strain cultures and from other mixed bacterial cultures, which include  L. reuteri  DAN080 strain and from purified or isolated cultures of prokaryotic and eukaryotic recombinants, in which and/or from which genes are utilized, which genes provide specific modulatory, inhibitory, homeostatic activity with respect to  Helicobacter pylori  and other bacteria or their mixtures for prophylaxis and treatment of medical conditions developing as a result of infections caused by bacteria, fungi, and other pathogens of the alimentary tract, body surface and other systems, such as urogenital, respiratory systems in vertebrates. 
     The present invention provides for a protection against medical conditions of body surface in vertebrates, including mammals and birds and for treatment of those conditions.