baber/WOPTO huggingface dataset:
Patent PT-705272-E (PT)
Inventor: TUBA ZOLTAN
IPC: C07J73/00
Filed: 1993-06-24
Abstract: The invention relates to a novel process for preparing 17 beta -substituted 4-azaandrostane derivatives of general formula (I) wherein R represents hydrogen or a C1-3alkyl group; R<1> represents a carboxamido group mono- or disubstituted by C1-8alkyl group(s); or a free carboxyl group; or a carboxyl group esterified with a C1-5 alcohol; and the - &cir& _- &cir& _- &cir& _- &cir& _ bond line represents a single or double bond; as well as their salts. The process comprises reacting a 17-halogeno-4-azaandrostene derivative of general formula (II) wherein R and the - &cir& _- &cir& _- &cir& _- &cir& _ bond line are as defined above, and X is chlorine, bromine or iodine, with a primary or secondary alkylamine or a C1-5 alcohol, in dimethylformamide or dimethylsulfoxide medium in the presence of a palladium(II) salt and phosphines or a palladium(II) complex and a tertiary amine base in carbon monoxide atmosphere at a temperature between 35  DEG C and 80  DEG C, then, if desired, transforming an obtained compound of general formula (I) to another compound of general formula (I) by hydrogenation, hydrolysis or salt forming reaction.
Patent PT-625354-E (PT)
Inventor: KURRLE ROLAND
IPC: C12N15/09
Filed: 1994-04-12
Abstract: The present invention relates to a medical preparation containing subunit p40 of interleukin 12. This medical preparation is particularly suitable for treating diseases associated with faulty regulation of the immune system.
Patent PT-730448-E (PT)
Inventor: GARFIELD ROBERT E
IPC: A61K38/095
Filed: 1994-11-17
Abstract: Dysmenorrhea, disfunctional uterine bleeding, preterm labor and postpartum labor in female mammals are treated by inhibiting uterine contractility by administering thereto a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in combination with one or more of a prostaglandin inhibitor, a prostacyclin-mimetic, a progestin, an oxytocin antagonist or a  beta -agonist in an amount effective to ameliorate the symptoms thereof; and inadequate menses treated and induction of abortion or stimulation of labor in a pregnant female is achieved by uterine contractility stimulation by administering thereto a nitric oxide inhibitor, either alone or in a combination of progesterone antagonist, an oxytocin or oxytocin analogue antagonist or prostaglandin.
Patent PT-744401-E (PT)
Inventor: RODUIT JEAN-PAUL
IPC: C07D241/04
Filed: 1996-05-22
Abstract: Prodn. of optically active piperazine-2-carboxylic acid derivs. of formula (I) comprises asymmetric hydrogenation of the corresp. 1,4,5,6-tetrahydropyrazine-2-carboxylic acid derivs. of formula (II) in the presence of an optically active rhodium, ruthenium and/or iridium complex catalyst: R<1>, R<2> = H, 1-4C alkyl, opt. substd. 1-6C alkanoyl, 2-6C perfluoroalkanoyl, aroyl, aralkyl, 2-7C alkoxycarbonyl, aryloxycarbonyl, CONH2 or N-protecting gps.; X = H, 1-6C alkoxy or NR<3>R<4>; R<3>, R<4> = H, 1-6C alkyl, 3-6C cycloalkyl, aryl or N-protecting gps.; or NR<3>R<4> = satd. 5- or 6-membered ring; or R<3> = H and R<4> = CH(R<5>)COOR<6>; R<5> = H or an amino acid side chain; R<6> = H, 1-4C alkyl or aryl. Also claimed are (a) optically active (I) where one of R<1> and R<2> is 1-6C alkanoyl or 2-6C perfluoroalkanoyl, and their enantiomer mixts.; and (b) (II) provided that R<1> and R<2> are not both H.
Patent PT-771759-E (PT)
Inventor: GIMENEZ JUAN CASADO
IPC: B01D53/32
Filed: 1996-03-28
Abstract: The process comprises the following steps: a) bringing into contact an oxygen containing gas with a gas diffusion cathode which does not contain a hydrogen peroxyde decomposition catalyst, b) providing a potential difference between the cathode and an anode, so that the oxygen is converted to peroxyde at the cathode, the peroxyde is diffused through an aqueous electrolyte up to the anode, and the peroxyde is converted to pure oxygen at the anode, the process is a new method capable of separating the oxygen through a bielectronic process. The equipment comprises a single compartment electrolytic cell (1) with at least one cathode (8) and one anode (9), an inlet (12) through the cathode for the introduction of a gas mixture which contains oxygen and an outlet (5) for pure oxygen produced in the cell. <IMAGE>
Patent PT-818274-E (PT)
Inventor: ALARY JEAN-ANDRE
IPC: B24C11/00
Filed: 1997-07-09
Abstract: The surfaces of components made of aluminium or their alloys are treated by sand blasting, using an abrasive powder projected against the surfaces in a jet of compressed air. The powder is prepared by electro-melting a mix of corundum and 20-45% by weight of zirconia.
Patent PT-957899-E (PT)
Inventor: SHIVANAND PADMAJA
IPC: A61K9/20
Filed: 1997-08-08
Abstract: A bilayer and trilayer tablet and a dosage form are disclosed for administering a controlled and increasing dose of drug over time. A method is disclosed also for administering an increasing dose of drug over time.
Patent PT-876103-E (PT)
Inventor: DITTRICH BERND
IPC: A21B3/07
Filed: 1997-11-14
Abstract: New system stores dough portions for a limited interval, before reaching the baking oven (1). It stores the dough portions in stacked, separated, levels (6). The portions rest on trays (2) and in any one level, the trays lie closely, side-by-side together. Moving a tray in the first cabinet section on the loading side, slides along all the other trays in the same level.
Patent PT-884244-E (PT)
Inventor: RELLO ROBERT M
IPC: B65C9/24
Filed: 1995-11-20
Abstract: A method and apparatus is disclosed for applying a label onto a substantially cylindrical article. The label drum (32) defines an article wrapping position. A thin layer, heat activated adhesive backed label (5) is fed onto a label receiving position of the drum. The label receiving positions of the drum are formed of a substantially smooth, resilient material, such as silicon. The label drum is rotated to move the label retained thereon into the article wrapping position. As the label is moved, the adhesive is heated so that the adhesive obtains a sufficient temperature to melt. A jet of air is blown onto the resilient surface for cooling the surface during subsequent label applying and ensuring rapid cooling of melted adhesive during labeling.
Patent PT-1044632-E (PT)
Inventor: BRIOSI ANTONELLO
IPC: A47B57/40
Filed: 1999-04-15
Abstract: The two ends (3) of the girders (1) utilised for the formation of modular shelves are provided with superposed double fasteners (4) wherein the inlet (4a) and outlet (4b) eyelets which circumscribe the passage slits, are perfectly equal and coaxial with each other. The couples of fasteners (4), located near the corners of the ends of the girders, engage in restrained relation and correct vertical alignment with as many superposed indentations (5), obtained along the vertical edges of uprights (6). Indentations (5) and couples of fasteners (4) have the same distance between centres and combine with each other, in stable and aligned restrained coupling, thanks to the equal and coaxial configuration of the sections of the passage slits of said fasteners. <IMAGE>
Patent SG-36992-G (SG)
Title: Interpolymers of vinyl chloride and polyimides
IPC: C08F283/04
Filed: 1992-04-01
Abstract: Interpolymers of vinyl chloride and polyimide in a weight ratio of from 49:1 to 1.5:1 are disclosed. The polyimide has substantially no active acid and/or anhydride functional groups. Interpolymers of the present invention may show improved heat distortion resistance and processing characteristics. A process for the preparation of the interpolymer is also disclosed.
Patent SG-32583-G (SG)
Title: 1-indolylalky-4-(substituted-pyridinyl) piperazines
Inventor: SMITH DAVID WILLIAM
IPC: C07D401/14
Filed: 1989-06-09
Abstract: A compound of Formula I and the pharmaceutically acceptable acid addition salts thereof, <CHEM>  wherein R<1> and R<2> are independently selected from lower, meaning C1-4, alkyl or hydrogen; R<3>, R<4>, R<8> and R<9> are independently selected from hydrogen, lower alkyl, lower alkoxy, carbamide, halogen, trifluoromethyl and thio-lower alkyl, with the proviso that R<8> and R<9> cannot both be hydrogen at the same time;  A is a C5-7 cycloalkanyl or cycloalkenyl ring, or  A is <CHEM> wherein n is an integer from 1 to 3 and R<5> is the same as R<1>; and R<6> and R<7> are independently selected from hydrogen, methyl or R<6> and R<7> can be taken together as a methylene bridge, useful as antidepressants.
Patent IE-42257-L (IE)
Title: Production of low-ash products derived from coal
IPC: C10G1/06
Filed: 1976-01-30
Abstract: Low-ash carbonaceous matls. are produced by extracting finely divided coal with a hydrocarbon extractant in the presence of H2 at 200-500 degrees C (pref. 375-425 degrees C) and 10-750 (pref. 90-130) bar, separating the extract from the residue, and distilling the extract to obtain a recyclable extractant with a boiling range of 135-550 degrees C (pref. 189-290 degrees C) the latter being obtained by starting up the extraction with a heavy oil having a boiling range of 135-550 degrees C (pref. 210-460 degrees C) and a high aromatics content (pref. 80 wt %). The extracted products can be used as non-polluting fuels, starting matls. for the petrochemical industry, and for the prodn. of electrode coke or carbon block. The extractant used represents a compromise between the need to extract a high proportion of the coal with a low H2 consumption and the need to recover the extractant for recycle. The extractant does not require hydrogenation before recycle, and the extract obtained is readily filtrable.
[FR2299393A1]
Patent IE-42501-L (IE)
Title: Seat for vehicle.
IPC: B60N2/75
Filed: 1976-03-03
Abstract: In the case of the seat (2) which is arranged along the central aisle in buses and bounds the said aisle, the armrest (3) is designed such that it can be pivoted out of an in-use position (G) into a stand-by position (B) in which it makes it possible for a person to sit on the seat and walk down the central aisle without being obstructed. The armrest (3) therefore has an angular leg (7), the length (L) of which corresponds approximately to half the distance (A) measured on the backrest (5) between the in-use position (G) and the stand-by position (B) located to the side of the sitting area (4). The free end of the leg (7) is mounted such that it can pivot about an axis (10) which runs parallel to the longitudinal direction of the horizontal part (8) of the armrest (3). On being pivoted through approximately 180 DEG the armrest (3) is transferred from the in-use position (G) into the stand-by position (B) or vice versa. In both positions (G or B) the armrest (3) is designed such that it can be locked automatically. <IMAGE>
[GB1541885A]
Patent IE-830450-L (IE)
Title: Preparation of polysaccharide-protein complexes
IPC: A61K39/095
Filed: 1983-03-03
Abstract: Process for the non-degrading preparation of polysaccharide-protein complexes from bacterial capsules; the so-obtained products which are useful as vaccines against infection by the same bacteria and method for protecting human beings against the same infection by administration of pharmaceutical composition containing the polysaccharide-protein complexes.
Patent IE-800609-L (IE)
Title: Thiazolinyl-pyrazine carboxamide
IPC: A61K31/54
Filed: 1980-03-25
Abstract: The case involves novel pyrazinecarboxamide compounds and processes for preparing same. The pyrazinecarboxamides are eukalemic agents possessing diuretic and natriuretic properties.
Patent IE-800806-L (IE)
Title: Inhibitors of testosterone 5-alpha-reductase
IPC: C07J31/00
Filed: 1980-04-22
Abstract: The title compounds are of formula <IMAGE> wherein R is =O, -OH, -OCO(C1-5 alkyl), -COOH, -CH2OH, -CHO, -COO(C1-6 alkyl), -COCH3, -CH(CH3)-COOH, -CH(CH3)- COO(C1-6 alkyl), beta -O-(CH2)3- alpha or a 20 beta -isomer of -CH(CH3-)- CH2OH, CH(CH3)-CHO, -CH(CH3)-COOH or -CH(CH3)- COO(C1-6 alkyl). These compounds have utility as inhibitors of the enzyme which converts testosterone to dihydrotestosterone, and may be made up into pharmaceutical compositions for treating acne and oily skin.
[GB2048888A]
Patent IE-860987-L (IE)
Title: Triazole derivatives
IPC: C07D471/04
Filed: 1986-04-16
Abstract: Triazole compounds of the formula:   <IMAGE>   in which: X and X', which are the same or different, each represents hydrogen, halogen, trifluoromethyl, C1-5alkyl, or C1-5 alkoxy, or X and X' together represent methylenedioxy, n is an integer of from 1 to 6, a is 0, 1 or 2; b is 0, 1, 2 or 3; c is 0, 1 or 2 and d is 2, 3, 4 or 5 such that a+b+c+d is equal to 4, 5, 6 or 7. These compounds and physiologically tolerable acid addition salts thereof may be used as medicines especially in the treatment of pain and anxiety.
Patent FI-824420-L (FI)
Inventor: GNEHM RENE
IPC: C07D209/28
Filed: 1982-12-22
Abstract: 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid carboxymethyl ester as known per se is obtainable by a novel and more simple method comprising mild acid hydrolysis of 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetoxyacetic tetrahydropyran-2-yl ester. The final product is a valuable drug having antiinflammatory activity.
Patent FI-830050-L (FI)
Inventor: ZAGEFKA HANS-DIETER
IPC: B27K3/15
Filed: 1983-01-07
Abstract: Wood and wooden materials are treated with aqueous treatment media. These media contain a water-soluble or water-dispersible, oxidatively drying, organic binder. The latter is a low-molecular weight, optionally modified 1,3-butadiene polymer which carries quaternary ammonium groups. This polymer is obtained by reacting an epoxy-group-containing polymer with a secondary and/or primary aliphatic amine and reacting the amination product with a low-molecular weight monoepoxide, during which process 0.05-0.5 mole of the quaternizable amino groups is quaternized per 100 g of the amination product. The treatment media preferably additionally contain wood preservatives and additives customary in the impregnating and varnishing field.
Patent FI-853132-L (FI)
Inventor: WEGMAN RICHARD WILLIAM
IPC: C07C69/14
Filed: 1985-08-15
Abstract: A process for the production of acetate esters by the catalytic reaction of an alcohol of the formula ROH and carbon monoxide in contact with a homogeneous catalyst system of rhodium metal atom, a phosphorus containing ligand in which there is present at least one oxo (=O) oxygen atom attached to a phosphorus atom or a carbon atom to form a Z group and the  @ or @   group in said Z group is located at least one carbon atom removed and preferably from 2-4 carbon atoms removed from the phosphorus atom of the molecules represented by the formulas <CHEM>  or <CHEM> and a halogen promoter, under mild reaction conditions, wherein R min is aryl, alkaryl, aralkyl or alkyl, and wherein 1 or more of said R min  groups can be substituted with a Z group but not more than 3 of said R min  groups in the molecule are so substituted: a is an integer from 0-4; b is an integer from 0-3; and Z is P(O)R min R min ; - C(O)OR sec  or C(O)R sec , wherein R sec  is R min  or -H; and wherein ROH is methanol or a mixture of methanol and at least one higher alcohol.
Patent IE-39294-L (IE)
Title: Acylureido cephalosporins
IPC: C07D501/28
Filed: 1974-05-29
Abstract: 1479711 Acylureido cephalosporins BEECHAM GROUP Ltd 4 June 1974 [12 June 1973 20 Oct 1973] 27970/73 and 48968/73 Heading C2C Novel cephalosporins of Formula (I) where Y is O or S, R<SP>1</SP> is an organic radical of up to 20C; R<SP>2</SP> is C 1-3 alkyl, or benzyl, or R<SP>1</SP> and R<SP>2</SP> together with the C and N atoms to which they are attached form a 5, 6 or 7-membered ring; R<SP>3</SP> is cyclohexadienyl, phenyl, phenyl substituted by one or more functional groups selected from hydroxy, halogen, nitro, C 1-3 alkoxy, amino, 2- or 3-thienyl, C 3-7 cycloalkyl, or C 1-4 alkyl; R<SP>4</SP> is acetoxy or a group of the formula or a pharmaceutically acceptable salt or ester thereof, may be obtained by (a) reacting a compound of Formula (II) or a salt, ester or silyl derivative thereof wherein the dotted line represents a bond in the 2- or 3-position, and n is 0 or 1, with a reactive N-acylating derivative of an acid of the Formula (III) R<SP>1</SP>C( =Y).N(R<SP>2</SP>).CONH.CH(R<SP>3</SP>).COOH and wherein any reactive groups may be blocked, or (b) reacting a compound (IV) or a salt, ester or silyl derivative thereof. wherein the dotted line represents a bond in the 2- or 3-position, with a compound of formula R<SP>1</SP>.C(=Y).N(R<SP>2</SP>)COCl or (c) in the case of compounds of Formula (I), where R<SP>4</SP> is other than acetoxy, reacting a compound of Formula (VI) or a salt, ester or silyl derivative thereof where the dotted line represents a bond in the 2 or 3 position, n is 0 or 1, and wherein any reactive groups may be blocked, with the appropriate nucleophile, and after reaction (a), (b) or (c) carrying out one or more of the following steps, if necessary; (i) converting a #<SP>2</SP> isomer to a #<SP>3</SP> isomer, (ii) removal of any silyl groups by alcoholysis or hydrolysis, (iii) reduction of a sulphoxide compound to form a desired sulphide compound, (iv) removal of any blocking groups in the acyl side chain R 1 , (v) conversion of an ester compound to a free acid compound or salt thereof.
[GB1479711A]
Patent IE-35778-L (IE)
Title: 4 - [4 -(ó - hydroxybenzyl) piperidino] - 4'¹fluorobutylprophenone derivatives
IPC: A61K31/445
Filed: 1971-10-27
Abstract: 1314955 Fluorobutyrophenone derivatives RICHARDSON-MERRELL Inc 27 Oct 1971 [27 Nov 1970] 49942/71 Heading C2C Novel compounds of the Formula I wherein R is hydrogen, chlorine, bromine, fluorine, C 1-4 alkyl or alkoxy, C 1-3 alkylthio, trifluoro methyl, phenyl, or phenoxy and salts thereof may be prepared by (a) condensing an appropriately substituted α-phenyl 4-piperidinemethanol with a 4-halo-4<SP>1</SP>-fluorobutyrophenone or (b) condensing an appropriately substituted 4-piperidylphenone with a 2-(3- halopropyl)-2-(p-fluorophenyl)-dioxolane to give an α-phenyl-1-{3-[2-(p-fluorophenyl) dioxolan- 2-yl]} propyl piperidyl ketone, followed by reduction of the keto group to give an α-phenyl- 1 - { 3 - [2 - (pfluorophenyl) dioxolan - 2 - yl]}- propyl-4-piperidinemethanol followed by hydrolysis of the dioxolane ring to form a keto group. The intermediate substituted α-phenyl-4- piperidine methanols may be prepared by (a) reduction of the corresponding ketone, (b) reacting a substituted phenyl Grignard reagent with 4-pyridine carboxaldehyde or 4-cyanopyridine followed by catalytic reduction of the intermediate. Pharmaceutical compositions of the compounds I show tranquillizing activity when administered orally or parenterally with the usual excipients.
[GB1314955A]
Patent IE-801392-L (IE)
Title: Phenoxy compounds.
IPC: C07D/
Filed: 1980-07-04
Abstract: The present invention concerns substituted heterocyclic phenoxyamines having the following formula: <IMAGE> their pharmacologically acceptable acid salts, their quaternary ammonium salts, their N-oxides, their levorotatory and dextrorotatory isomers and the processes for the preparation thereof. In the above formula: m=0 or 2 n=0 or 2 provided that m+n=2 A represents hydrogen, a lower alkoxy or lower alkenyloxy group, X represents a halogen, R represents hydrogen or a saturated or unsaturated aliphatic and/or cyclic hydrocarbon radical such as in particular lower alkyl, lower alkenyl, cycloalkyl and cycloalkyl-alkyl, cycloalkenyl and cycloalkenyl-alkyl. The compounds of the invention are useful as local anaesthetics.
[US4379161A]
Patent IE-38819-L (IE)
Title: Pivaloyloxymethyl penicillinate
IPC: C07D513/02
Filed: 1973-09-11
Abstract: 1413516 Medicines comprising penicillins LEO PHARMACEUTICAL PRODUCTS LTD AS (LOVENS KEMSKIE FABRIK PRODUKTIONS AS) 19 Sept 1973 [6 Oct 1972] 46317/72'Heading A5B [Also in Division C2] Pharmaceutical compositions having antibiotic activity comprise a novel crystalline form of pivaloyloxymethyl D-(-)-α-aminobenzylpenicillinate, characterised by I.R. absorption peaks at 3360, 3310, 1765-1745 and 1680 cm<SP>-1</SP> and a melting point of 115-117‹C, together with another antibiotically active penicillin or its salt and a pharmaceutical diluent or carrier. The other penicillin may be pivaloyloxymethyl 6-[(hexahydro-1-H-azepin-1-yl) methylamino] penicillinate. The compositions may be in forms suitable for oral administration.
[GB1413516A]
Patent IE-41756-L (IE)
Title: Self-extinguishing filaments
IPC: C08F220/44
Filed: 1975-10-17
Abstract: The invention relates to filaments and fibers the filament-forming substance of which is a copolymer of from 35 to 85 weight % of acrylonitrile, from 5 to 45 weight % of vinyl chloride, vinyl bromide and/or vinylidene chloride, from 5 to 30 weight % of carboxyphosphinic acid derivatives of the formula ##STR1## where R.sub.1 is lower alkyl having up to 8 carbon atoms, or CH.sub.2 Cl--, R.sub.2 is lower alkyl having up to 8 carbon atoms in which a hydrogen atom may be substituted by a halogen atom in case of R.sub.1 being CH.sub.2 Cl--, and R.sub.3 is hydrogen or methyl, and from 0 to 15 weight % of other unsaturated compounds having an activated double bond; the weight percentages being relative to the total amount of monomers, and a process for their manufacture. The filaments obtained are self-extinguishing and excel furthermore by their thermostability and their high degree of whiteness.[US4052551A]
Patent IE-812435-L (IE)
Title: Generating sequence of binary-weighted values
IPC: H03M1/00
Filed: 1981-10-16
Abstract: A device for generating a geometric sequence of values of an electrical quantity (charge or voltage) with the aid of switched capacitances. A switch control means operates a plurality of switches in a predetermined time pattern so as to distribute electric charges on a plurality of capacitors. A geometric sequence of electric charges is thus stored on the capacitors in which, first-order errors caused by inaccuracies in the capacitance values of the capacitors are eliminated. Furthermore, methods are proposed to minimize the influence of inevitable stray capacitances in the arrangement.
[US4471482A]
Patent IE-842963-L (IE)
Title: Electric circuit breaker with improved operating¹mechanism
IPC: H01H73/22
Filed: 1984-11-20
Abstract: A molded case circuit breaker includes a highly integrated operating mechanism having an over-center toggle mechanism for opening and closing a pair of electrical contacts and a trip mechanism for responding to overload and short circuit or fault current conditions to separate the pair of electrical contacts. A generally flat, intermediate latch plate includes an upper latch surface for latching with a movable cradle of the over-center toggle mechanism and a lower latch surface for latching with a trip bar of the trip mechanism and a pair of outwardly projecting pivot arms disposed between the upper and lower latch surfaces. The over-center toggle mechanism includes a pair of upper toggle links and a pair of lower toggle links interconnected by a toggle spring pin. To increase the speed of separation of the first and second electrical contacts during a trip operation, the cradle is physically configured to engage and upwardly propel the toggle spring pin and, also, the upper toggle links have projections for physically contacting a rigid stop.
[US4528531A]
Patent IE-852975-L (IE)
Title: Milking machine pulsation arrangement
IPC: A01J5/14
Filed: 1985-11-26
Abstract: A milking machine pulsation arrangement which includes a pulsation rate and ratio timing device in combination with a first coil and vacuum pulsator unit operated by the coil and at least one associated coil and vacuum pulsation unit controlled thereby, for controlling a plurality of milking machine pulsator units. A time delay device is connected to and associated with pulsation rate and ratio timing device and the at least one associated coil so that the time delay device is adapted to receive electrical current pulse of predetermined interval and duration and thereafter substantially reproduce the current pulse.
[US4690099A]