Patent SG-11201805442X-A (SG)
Title: Compositions and methods related to multimodal therapeutic cell systems for immune indications
Inventor: KAHVEJIAN AVAK
IPC: A61K35/18
Filed: 2017-01-11
Abstract: INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 11M1111101110101011111 HO 1111101110111011100110011101111111110111011# International Bureau .. .... ..Yejd (10) International Publication Number (43) International Publication Date ..... .....!;,' WO 2017/123644 Al 20 July 2017 (20.07.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 35/12 (2015.01) Cl 2N 5/10 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 35/18 (2015.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US2017/013033 HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, (22) International Filing Date: KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, 11 January 2017 (11.01.2017) MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (25) Filing Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (26) Publication Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 62/277,130 11 January 2016 (11.01.2016) US (84) Designated States (unless otherwise indicated, for every 62/359,448 7 July 2016 (07.07.2016) US kind of regional protection available): ARIPO (BW, GH, 62/370,915 4 August 2016 (04.08.2016) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, 62/420,973 11 November 2016 (11.11.2016) US TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, (71) Applicant: RUBIUS THERAPEUTICS, INC. [US/US]; DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, 620 Memorial Dr #100W, Cambridge, MA 02139 (US). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (72) Inventors: KAHVEJIAN, Avak; 1 Memorial Drive, 7th SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, _ Floor, Cambridge, MA 02142 (US). MATA-FINK, Jordi; GW, KM, ML, MR, NE, SN, TD, TG). — 8 Windsor Rd # 1, Somerville, MA 02144 (US). DEANS, Declarations under Rule 4.17: _ Robert, J.; 1609 Ramsgate Court, Riverside, CA 92506 — as to applicant's entitlement to apply for and be granted a (US). CHEN, Tiffany, F.; 91 Sidney St. Apt 207, Cam- 4.17(ii)) patent (Rule = bridge, MA 02139 ROUND, 1 Memorial (US). John; Drive, 7th Floor, Cambridge, MA 02142 AFEYAN, — as to the applicant's entitlement to claim the priority of the (US). Noubar, B.; 1 Sunset Ridge, Lexington, MA 02421 (US). earlier application (Rule 4.17(iii)) = STRAIGHT NISSEN, Torben; 68 Waban Hill Rd., Published: = Chestnut Hill, MA 02467 (US). DOWDEN, Nathan; 4 = — with international search report (Art. 21(3)) Goddu Ave., Winchester, MA 01890 (US). WICKHAM, = Tom; 20 Hickory Lane, Grodon, MA 01450 (US). —— before limit the expiration of the time for amending the to be in the event of receipt of (74) Agent: KOYFMAN, Hannah, R.; Lando & Anastasi, claims and republished LLP, Riverfront Office Park, One Main Street, Suite 1100, amendments (Rule 48.2(h)) = Cambridge, MA 02142 (US). — with sequence listing of description (Rule 5.2(a)) part = = = = = = 1-1 7r 7r cr) ei ,-1 IN 1-1 (54) Title: COMPOSITIONS AND METHODS RELATED TO MULTIMODAL THERAPEUTIC CELL SYSTEMS FOR IM- C:= ei MUNE INDICATIONS 0 (57) : The invention includes compositions and methods related to multimodal therapies, e.g., for treating immune condi- tions. A multimodal therapy described herein provides and/or administers a plurality of agents that function in a coordinated manner to provide a therapeutic benefit to a subject in need thereof, e.g., a subject having an autoimmune disease or inflammatory disease.