Claim: Officials release edited coronavirus reopening guidance.
Verdict: SUPPORTS

Retrieved passages:
title: 2012 Middle East respiratory syndrome coronavirus outbreak
text: said virus. The Evangelista Medical Hospital in San Pedro, Laguna, the facility where the patient was first admitted, was temporarily closed by DOH for fourteen days. On 17 February 2015, all those who had exposure or had contact with the said nurse were tested negative of the said virus. On 6 March 2015, The Department of Foreign Affairs confirmed three Filipino female healthcare workers in Saudi Arabia who were infected with MERS-CoV. On 6 July 2015, DOH confirmed the second detected case of MERS-CoV in the country. The patient who had contracted the virus was from the Middle East and

title: Bovine coronavirus
text: nasal washes – which identifies the viral antigen. The haemagglutination inhibition test can be used to establish the strain of coronavirus. Animals should be treated symptomatically. The disease can be controlled by vaccinating the dam with a live vaccine (ATCvet code QI02) whilst she is pregnant as this provides antibodies to the virus in the colostrum. Additional management factors such as ensuring adequate colostrum intake in newborn calves, using appropriate hygiene methods and ventilation of housing reduce disease incidence. Bovine coronavirus Bovine coronavirus (BCV) is as a member of the Coronaviridae family which are enveloped, single-stranded, positive-sense RNA viruses with

title: Human coronavirus OC43
text: cases occurring in the winter months. Human coronavirus OC43 Human coronavirus OC43 is an enveloped, positive-stranded RNA virus in the species "Betacoronavirus-1" (genus "Betacoronavirus", subfamily "Coronavirinae", family "Coronaviridae", order "Nidovirales"). Four HCoV-OC43 genotypes (A to D), have been identified with genotype D most likely arising from recombination. The complete genome sequencing of two genotype C and D strains and bootscan analysis shows recombination events between genotypes B and C in the generation of genotype D. Of 29 strains identified, none belong to the more ancient genotype A. Molecular clock analysis using spike and nucleocapsid genes dates the most recent common

title: Human coronavirus OC43
text: Human coronavirus OC43 Human coronavirus OC43 is an enveloped, positive-stranded RNA virus in the species "Betacoronavirus-1" (genus "Betacoronavirus", subfamily "Coronavirinae", family "Coronaviridae", order "Nidovirales"). Four HCoV-OC43 genotypes (A to D), have been identified with genotype D most likely arising from recombination. The complete genome sequencing of two genotype C and D strains and bootscan analysis shows recombination events between genotypes B and C in the generation of genotype D. Of 29 strains identified, none belong to the more ancient genotype A. Molecular clock analysis using spike and nucleocapsid genes dates the most recent common ancestor of all genotypes to the

title: Coronavirus
text: of a vaccine against the disease "since [the spike protein] appears to be recognized by the immune system of the host." Following the high-profile publicity of SARS outbreaks, there has been a renewed interest in coronaviruses among virologists. For many years, scientists knew about only two human coronaviruses (HCoV-229E and HCoV-OC43). The discovery of SARS-CoV added a third human coronavirus. By the end of 2004, three independent research labs reported the discovery of a fourth human coronavirus. It has been named NL63, NL, and the New Haven coronavirus by different research groups. The three labs are still arguing over which

title: Coronavirus frameshifting stimulation element
text: families identified in the coronavirus include the SL-III cis-acting replication element (CRE), the coronavirus 3' stem-loop II-like motif (s2m), the coronavirus packaging signal and the coronavirus 3' UTR pseudoknot. During protein synthesis, rapidly changing conditions in the cell can cause ribosomal pausing. In coronaviruses, this can affect growth rate and trigger translational abandonment. This releases the ribosome from the mRNA and the incomplete polypeptide is targeted for destruction. Coronavirus frameshifting stimulation element In molecular biology, the coronavirus frameshifting stimulation element is a conserved stem-loop of RNA found in coronaviruses that can promote ribosomal frameshifting. Such RNA molecules interact with a

title: Coronaviridae
text: selection and packaging is critical for developing antiviral strategies and viral expression vectors based on the coronavirus genome. Coronaviridae Coronaviridae is a family of enveloped, positive-sense, single-stranded RNA viruses. The viral genome is 26–32 kb in length. Virions are spherical, 120–160 nm across ("Coronavirinae"), bacilliform, 170–200 by 75–88 nm ("Bafinivirus") or found as a mixture of both, with bacilliform particles characteristically bent into crescents ("Torovirus"). The particles are typically decorated with large (~20 nm), club- or petal-shaped surface projections (the “peplomers” or “spikes”), which in electron micrographs of spherical particles create an image reminiscent of the solar corona. Members of

title: Coronavirus 3' stem-loop II-like motif (s2m)
text: recombination events. Other RNA families identified in the coronavirus include the SL-III cis-acting replication element (CRE), the coronavirus frameshifting stimulation element, the coronavirus packaging signal and the coronavirus 3' UTR pseudoknot. Functionally during host invasion by viral RNA, it appears that s2m first binds one or more proteins as a mechanism for the viral RNA to substitute host protein synthesis. This has also been seen in s2m RNA macromolecular substitution of ribosomal RNA folds. The s2m RNA element are also effective targets for the design of anti-viral drugs. Coronavirus 3' stem-loop II-like motif (s2m) The Coronavirus 3' stem-loop II-like motif

title: Coronavirus packaging signal
text: RNA to be specificity packaged into virions. Other RNA families identified in the coronavirus include the SL-III cis-acting replication element (CRE), the coronavirus frameshifting stimulation element, the coronavirus 3' stem-loop II-like motif (s2m) and the coronavirus 3' UTR pseudoknot. Coronavirus packaging signal The Coronavirus packaging signal is a conserved cis-regulatory element found in Coronavirus which has an important role in regulating the packaging of the viral genome into the capsid. As part of the viral life cycle, within the infected cell, the viral genome becomes associated with viral proteins and assembles into new infective progeny viruses This process is called

title: Middle East respiratory syndrome
text: pneumonia and acute renal failure. After routine diagnostics failed to identify the causative agent, Zaki contacted Ron Fouchier, a leading virologist at the Erasmus Medical Center (EMC) in Rotterdam, the Netherlands, for advice. Fouchier sequenced the virus from a sample sent by Zaki. Fouchier used a broad-spectrum "pan-coronavirus" real-time polymerase chain reaction (RT-PCR) method to test for distinguishing features of a number of known coronaviruses (such as OC43, 229R, NL63, and SARS-CoV), as well as for RNA-dependent RNA polymerase (RdRp), a gene conserved in all coronaviruses known to infect humans. While the screens for known coronaviruses were all negative, the

title: Alphacoronavirus
text: expressed from a 3'-coterminal nested set of subgenomic mRNAs. Alphacoronavirus Alphacoronaviruses are the first of the four genera, alpha-, beta-, gamma-, and delta-coronavirus in the subfamily "Coronavirinae" of the family "Coronaviridae". Coronaviruses are enveloped, positive-sense, single-stranded RNA viruses that include both human and zoonotic species. Within this subfamily, viruses have spherical virions with club-shaped surface projections and a core shell. The name is from the Latin corona, meaning crown, which describes the appearance of the projections seen under electron microscopy that resemble a solar corona. This genus contains what were previously considered phylogroup 1 coronaviruses. Both the alpha- and beta-coronavirus

title: 2012 Middle East respiratory syndrome coronavirus outbreak
text: coronavirus researcher at the Erasmus Medical Center (EMC) in Rotterdam, The Netherlands. The second laboratory-proven case was in London, confirmed by the UK Health Protection Agency (HPA). The HPA named the virus the London1_novel CoV 2012. On 8 November 2012, in an article published in the New England Journal of Medicine, Dr. Zaki and co-authors from the Erasmus Medical Center published more details, including a scientific name, Human Coronavirus-Erasmus Medical Center (HCoV-EMC), which was then used in scientific literature. In the article, they noted four respiratory human coronaviruses (HCoV) known to be endemic: 229E, OC43, NL63, and HKU1. In May

title: Alphacoronavirus
text: Alphacoronavirus Alphacoronaviruses are the first of the four genera, alpha-, beta-, gamma-, and delta-coronavirus in the subfamily "Coronavirinae" of the family "Coronaviridae". Coronaviruses are enveloped, positive-sense, single-stranded RNA viruses that include both human and zoonotic species. Within this subfamily, viruses have spherical virions with club-shaped surface projections and a core shell. The name is from the Latin corona, meaning crown, which describes the appearance of the projections seen under electron microscopy that resemble a solar corona. This genus contains what were previously considered phylogroup 1 coronaviruses. Both the alpha- and beta-coronavirus lineages descend from the bat gene pool. The virion

title: Coronavirus
text: 2013, a case of contamination from human to human in France was confirmed by the French Ministry of Social Affairs and Health. In addition, cases of person-to-person transmission have been reported by the Ministry of Health in Tunisia. Two confirmed cases seem to have caught the disease from their late father, who became ill after a visit to Qatar and Saudi Arabia. By Oct. 30 2013, there were 124 cases and 52 deaths in Saudi Arabia. After the Dutch Erasmus Medical Centre sequenced the virus, the virus was given a new name, Human Corona Virus-Erasmus Medical Centre (HCoV-EMC). The final

title: Coronavirus
text: Coronavirus Coronaviruses are species of virus belonging to the subfamily "Coronavirinae" in the family "Coronaviridae", in the order Nidovirales. Coronaviruses are enveloped viruses with a positive-sense single-stranded RNA genome and with a nucleocapsid of helical symmetry. The genomic size of coronaviruses ranges from approximately 26 to 32 kilobases, the largest for an RNA virus. The name "coronavirus" is derived from the Latin "corona", meaning crown or halo, and refers to the characteristic appearance of virions under electron microscopy (E.M.) with a fringe of large, bulbous surface projections creating an image reminiscent of a royal crown or of the solar corona.

title: Coronavirus
text: This morphology is created by the viral spike (S) peplomers, which are proteins that populate the surface of the virus and determine host tropism. Proteins that contribute to the overall structure of all coronaviruses are the spike (S), envelope (E), membrane (M) and nucleocapsid (N). In the specific case of the SARS coronavirus (see below), a defined receptor-binding domain on S mediates the attachment of the virus to its cellular receptor, angiotensin-converting enzyme 2 (ACE2). Some coronaviruses (specifically the members of Betacoronavirus subgroup A) also have a shorter spike-like protein called hemagglutinin esterase (HE). Coronaviruses were first described in the

title: Middle East respiratory syndrome coronavirus
text: and were therefore delaying the development of diagnostic tests. Erasmus MC responded that the patent application did not restrict public health research into MERS coronavirus, and that the virus and diagnostic tests were shipped—free of charge—to all that requested such reagents. There are a number of mapping efforts focused on tracking MERS coronavirus. On 2 May 2014, the Corona Map was launched to track the MERS coronavirus in realtime on the world map. The data is officially reported by WHO or the Ministry of Health of the respective country. HealthMap also tracks case reports with inclusion of news and social

title: 2012 Middle East respiratory syndrome coronavirus outbreak
text: of unknown origin. Of the six, two died. All the cases were reported to the European Centre for Disease Prevention and Control (ECDC). After the September identification of a novel CoV strain, a retroactive analysis of the hospital workers was performed. Epidemiologists discovered the Jordan cases. Using stored laboratory samples for all six, it was found that samples from the two patients who had died tested positive for nCoV. On 24 April 2014, a 25-year-old male was found positive for the coronavirus. He had history of exposure to camels and had consumed camel milk. The Ministry of Health and Medical

title: Transmissible gastroenteritis coronavirus
text: as an expression vector. The vector was constructed by replacing the nonessential 3a and 3b ORF, which is driven by the transcription-regulating sequences (TRS) with green fluorescent protein. The resulting construct was still enteropathogenic, but with reduced growth. The infection of cells with this altered virus elicits a specific lactogenic immune response against the heterologous protein. The application of this vector is in the development of a vaccine or even gene therapy. The motivation for engineering the TGEV genome is that coronaviruses have large genomes, so they have room for insertion of foreign genes. Coronaviruses also infect the respiratory tract,

title: Coronavirinae
text: Coronavirinae Coronavirinae is one of two subfamilies in the family Coronaviridae. It is subdivided into the genera alphacoronavirus, betacoronavirus, gammacoronavirus, and deltacoronavirus. These include phylogenetically compact genogroups of enveloped, positive-sense, single-stranded RNA and with a nucleocapsid of helical symmetry. The genomic size of coronaviruses ranges from approximately 26 to 32 kilobases, extraordinarily large for an RNA virus. Their numbers are growing rapidly with several novel coronaviruses being recently discovered including Middle East respiratory syndrome coronavirus MERS-CoV discovered in 2012. The genus alphacoronavirus (formerly known as Coronavirus group 1 (CoV-1)) includes subgroups 1a and 1b, which are prototyped by human coronavirus