With short-term and long-term use of alprazolam, patients may experience withdrawal symptoms including seizures. If you experience a seizure while taking alprazolam, it is considered a serious side effect and you should contact your doctor immediately. To minimize the possibilities of this serious side effect, alprazolam should be taken only as prescribed and not with any other drugs that affect brain chemicals unless they are prescribed by a doctor who is aware of all the medications a patient is taking.