If it's your first time. Some people can take Xanax and drink a few beers; others this will lead to a coma or death. I've known a few people who have died from 2 beers and a Xanax. Have fun and make sure your at home or a place you can crash and sleep ;. Weed will be fine to mix with it however. You don't wanna mix xanax and alcohol because they are both CNS depressants, and the combined effects of both can slow your breathing down enough to the point that if you fall asleep you will just stop breathing and die.