the prevalence of papillary thyroid microcarcinoma is increasing in recent years , and a large proportion of these patients are young women .
therefore , minimally invasive endoscopic thyroidectomy with central neck dissection ( cnd ) emerged and showed well - accepted results with improved cosmetic outcome , accelerated healing , and comforting the patients .
robotic thyroidectomy via a transaxillary approach was first described by kang et al . in 2009 .
thereafter , various operative approaches , including axillary - breast - anterior chest approach , transoral periosteal approach , and retroauricular approach , were introduced by many surgeons .
the aim of this prospective randomized study was to evaluate the safety and effectiveness of robotic total thyroidectomy with cnd via bilateral axillo - breast approach ( baba ) , compared to the conventional low - collar incision method for the treatment of papillary thyroid microcarcinoma .
the study was approved by the research ethics committee of jinan military general hospital of people 's liberation army ( pla ) .
the prospective randomized clinical study involved 100 patients with papillary thyroid microcarcinoma ( 17 males and 83 females ) , with an average age of 41.2 years ( range : 2163 years ) , from march 2014 to january 2015 , in jinan military general hospital of pla . before grouping
, we described the operative methods and relative complications between robotic thyroidectomy and open thyroidectomy to the patients .
then , the patients were randomly given a number and assigned to the corresponding group : 50 patients received robotic total thyroidectomy with cnd via baba ( using da vinci si surgical system , intuitive surgical inc . ,
sunnyvale , ca , usa ) , and 50 were operated with conventional low - collar incision approach .
the inclusion criteria for this prospective randomized study were as follows : ( 1 ) intrathyroidal papillary carcinoma smaller than 10 mm in diameter ; and ( 2 ) no evidence of central or lateral lymph node metastasis .
all patients were evaluated preoperatively via sonography , fine - needle aspiration cytology , thyroid function , and/or computed tomography ( ct ) .
the exclusion criteria included a history of thyroiditis , graves disease , previous neck or thyroid surgeries , irradiation history , obesity ( body mass index > 30 kg / m ) , enlarged thyroid gland detected by ultrasound examination ( one thyroid lobe volume > 40 ml ) , and a possible extrathyroidal extension or abutment on the thyroid capsule , especially when occurrence was near the tracheoesophageal groove detected by preoperative sonography or ct .
we analyzed the medical records and evaluated surgical outcomes including the total operative time , estimated intraoperative blood loss , numbers of lymph node removed , visual analog scale ( vas ) , postoperative hospital stay time , complications , and numerical scoring system ( nss ) in all patients .
the cosmetic results were recorded using a scoring system ranging from 1 to 4 levels ( 1 : extremely , 2 : fairly , 3 : normal , and 4 : not at all ) , and nss was used for patients self - assessment in the outpatient clinic at 1 month and 3 months after the operation to grade the cosmetic outcome between 0 and 10 .
all patients were followed up in outpatient clinic at 1 , 3 , and 6 months , and then every 6 months to detect thyroid function and thyroglobulin ( tg ) level .
robotic total thyroidectomy under general endotracheal anesthesia , patients were placed on the operating table in the supine position with the neck extended slightly and both arms slightly abducted to allow insertion of the axillary port . after draping , we draw the instrument arm trajectory lines and working area on patient 's chest and neck for reference [ figure 1 ] . using a 23-gauge spinal needle , we injected diluted epinephrine solutions ( 1:200,000 , 100 ml ) and ropivacaine hydrochloride ( 100 mg ) into the subcutaneous areas of both breasts and axilla , as well as the subplatysmal layer of the neck for easy dissection and less bleeding . drawing instrument arm trajectory lines and working area .
baba included 5 mm or 8 mm axillary crease incisions and two circumareolar incisions about 8 mm on the left side and 12 mm on the right side , respectively .
the 12-mm circumareolar incision was used as a camera port and can be moved to the left breast if the surgeon prefers .
blunt dissection was carefully performed with a vascular tunneler from the incision superiorly to the suprasternal fossa [ figure 1 , area a ] in trajectory lines and laterally to the medial border of the sternocleidomastoid muscle .
once the working space was found , the robotic column was placed parallel to the camera port and trocars were inserted into tunnels .
place the camera port first ( e port ) using a disposable 12 mm trocar .
place the instrument arm 2 or 3 port in the trocars of the axilla followed by docking the robot cart [ figure 2 ] .
following above procedures , the 30 endoscope was placed in the circumareolar area on the side of the lesion through a 12 mm trocar .
then , the harmonic scalpel was placed on the circumareolar area on the contralateral side through an 8 mm trocar .
furthermore , a 5 mm maryland dissector was placed in the axillary area ( same side as the lesion ) and 5 mm prograsp forceps ( intuitive inc . ,
sunnyvale , ca , usa ) were placed in the axillary area on the contralateral side , as shown in figure 2 .
the working space was extended superiorly , laterally , and inferiorly to the level of the thyroid cartilage , the medial border of each sternocleidomastoid muscle , and the anterior chest , respectively [ figure 1 , areas a and b ] .
after the sternocleidomastoid muscle and the strap muscle were identified , we cut through the linea alba cervicalis incision with a harmonic scalpel between the strap muscles from the suprasternal notch to thyroid cartilage .
the general principle of surgical procedures for robotic total thyroidectomy was the same as conventional open thyroidectomy .
we should identify the tracheal wall , expose it as a midline landmark , and dissect the lower pole of thyroid from the adipose tissue or trachea . during this procedure , we should avoid injuries to the tracheal wall .
with delicate blunt dissection , both thyroid lobes were exposed and examined for pathological changes , and with a strictly median orientation , the primary isthmus was removed using the harmonic scalpel .
the upper pole of the thyroid was drawn downward , and superior thyroid vessels were identified and individually divided close to the thyroid capsule to avoid injuring the external branch of the superior laryngeal nerve . during dissection , the superior parathyroid gland should be identified and left intact in situ [ figures 3 and 4 ] . identifying and protecting parathyroid glands and the recurrent laryngeal nerve .
robotic total thyroidectomy with central neck dissection showing the course of the ipsilateral ( right ) recurrent laryngeal nerve and the superior parathyroid gland .
the thyroid was retracted medially , and the middle thyroid vein was identified and coagulated off carefully .
careful dissection was performed to avoid the inferior thyroid artery and the recurrent laryngeal nerve ( rln )
. we can easily identify and preserve the rlns under magnified 1015 times surgical view [ figures 3 and 4 ] .
after the inferior thyroid vein and thyrothymic ligament had been recognized , the thyroid was retracted upward and medially .
finally , proper application of the harmonic scalpel can successfully remove the thyroid gland from the trachea .
circular resection is recognized as a safe and highly effective method in robotic thyroidectomy via baba for bilateral thyroid lesions .
particular attention should be paid to ensure sufficient distance of the heated harmonic scalpel from the rln and the visible parathyroids .
we dissected the level 4 lymph nodes ( delphian / prelaryngeal , pretracheal , and paratracheal lymph nodes ) using the robotic system . during
ipsilateral or bilateral cnd , the lymph nodes of the central compartment were carefully dissected to avoid injuries to the rln and parathyroids .
application of carbon nanoparticles suspensions injection can stain the lymph nodes of the center compartment while leaving the parathyroid glands unstained ( because of the negative development of parathyroid glands to carbon nanoparticles , chongqing lummy pharmaceuticals , china ) , thus helping to identify and protect parathyroid glands and the rln [ figures 3 and 4 ] , as well as facilitating the identification and clearance of lymph nodes .
the resected specimen was extracted through enlarging the axillary skin incision by a specimen pouch .
vacuum - assisted draining system should be placed in the operative area though the axilla tunnel .
the wounds were closed with 5 - 0 absorbable monofilament sutures using an atraumatic needle , followed by placement of steri - strips .
conventional open approach patients in the conventional open approach group underwent conventional open total thyroidectomy with central lymph node dissection in the supine position with neck extension under general endotracheal anesthesia .
the lower layer of the platysma was cut through , and subplatysmal flap dissection was performed from the sternal notch to the level of the thyroid cartilage superiorly .
the linea alba cervicalis of the strap muscles was divided vertically , and the thyroid gland was exposed .
dissection of the thyroid and central lymph nodes was performed with harmonic focus ( ethicon endo - surgery inc . ,
, every effort was made to identify and preserve all parathyroid glands and the rlns with the negative development of parathyroid glands by carbon nanoparticles [ figure 5 ] .
parathyroid glands were transplanted in the sternocleidomastoid muscle once we found that the blood supply to the glands was compromised .
then , the surgical field was douched by 500 ml sterile distilled water ( 42c ) .
the wounds were closed by an atraumatic needle with 5 - 0 absorbable sutures . identifying and exposing recurrent laryngeal nerve , the negative development of parathyroid glands by carbon nanoparticles .
patients with no complications were usually discharged on day 3 to day 5 after the surgery .
descriptive statistics of quantitative variables , mean  standard deviation ( sd ) and range were used to describe central tendency and dispersion .
fisher 's exact test was used if the assumptions of chi - square test were violated .
independent samples t - test was used to compare the level of quantitative variables between the two groups .
the study was approved by the research ethics committee of jinan military general hospital of people 's liberation army ( pla ) .
the prospective randomized clinical study involved 100 patients with papillary thyroid microcarcinoma ( 17 males and 83 females ) , with an average age of 41.2 years ( range : 2163 years ) , from march 2014 to january 2015 , in jinan military general hospital of pla . before grouping
, we described the operative methods and relative complications between robotic thyroidectomy and open thyroidectomy to the patients .
then , the patients were randomly given a number and assigned to the corresponding group : 50 patients received robotic total thyroidectomy with cnd via baba ( using da vinci si surgical system , intuitive surgical inc . ,
sunnyvale , ca , usa ) , and 50 were operated with conventional low - collar incision approach .
the inclusion criteria for this prospective randomized study were as follows : ( 1 ) intrathyroidal papillary carcinoma smaller than 10 mm in diameter ; and ( 2 ) no evidence of central or lateral lymph node metastasis .
all patients were evaluated preoperatively via sonography , fine - needle aspiration cytology , thyroid function , and/or computed tomography ( ct ) .
the exclusion criteria included a history of thyroiditis , graves disease , previous neck or thyroid surgeries , irradiation history , obesity ( body mass index > 30 kg / m ) , enlarged thyroid gland detected by ultrasound examination ( one thyroid lobe volume > 40 ml ) , and a possible extrathyroidal extension or abutment on the thyroid capsule , especially when occurrence was near the tracheoesophageal groove detected by preoperative sonography or ct .
we analyzed the medical records and evaluated surgical outcomes including the total operative time , estimated intraoperative blood loss , numbers of lymph node removed , visual analog scale ( vas ) , postoperative hospital stay time , complications , and numerical scoring system ( nss ) in all patients .
the cosmetic results were recorded using a scoring system ranging from 1 to 4 levels ( 1 : extremely , 2 : fairly , 3 : normal , and 4 : not at all ) , and nss was used for patients self - assessment in the outpatient clinic at 1 month and 3 months after the operation to grade the cosmetic outcome between 0 and 10 .
all patients were followed up in outpatient clinic at 1 , 3 , and 6 months , and then every 6 months to detect thyroid function and thyroglobulin ( tg ) level .
robotic total thyroidectomy under general endotracheal anesthesia , patients were placed on the operating table in the supine position with the neck extended slightly and both arms slightly abducted to allow insertion of the axillary port . after draping , we draw the instrument arm trajectory lines and working area on patient 's chest and neck for reference [ figure 1 ] . using a 23-gauge spinal needle , we injected diluted epinephrine solutions ( 1:200,000 , 100 ml ) and ropivacaine hydrochloride ( 100 mg ) into the subcutaneous areas of both breasts and axilla , as well as the subplatysmal layer of the neck for easy dissection and less bleeding . drawing instrument arm trajectory lines and working area .
baba included 5 mm or 8 mm axillary crease incisions and two circumareolar incisions about 8 mm on the left side and 12 mm on the right side , respectively .
the 12-mm circumareolar incision was used as a camera port and can be moved to the left breast if the surgeon prefers .
blunt dissection was carefully performed with a vascular tunneler from the incision superiorly to the suprasternal fossa [ figure 1 , area a ] in trajectory lines and laterally to the medial border of the sternocleidomastoid muscle .
once the working space was found , the robotic column was placed parallel to the camera port and trocars were inserted into tunnels .
place the camera port first ( e port ) using a disposable 12 mm trocar .
place the instrument arm 2 or 3 port in the trocars of the axilla followed by docking the robot cart [ figure 2 ] .
following above procedures , the 30 endoscope was placed in the circumareolar area on the side of the lesion through a 12 mm trocar .
then , the harmonic scalpel was placed on the circumareolar area on the contralateral side through an 8 mm trocar .
furthermore , a 5 mm maryland dissector was placed in the axillary area ( same side as the lesion ) and 5 mm prograsp forceps ( intuitive inc . ,
sunnyvale , ca , usa ) were placed in the axillary area on the contralateral side , as shown in figure 2 .
the working space was extended superiorly , laterally , and inferiorly to the level of the thyroid cartilage , the medial border of each sternocleidomastoid muscle , and the anterior chest , respectively [ figure 1 , areas a and b ] .
after the sternocleidomastoid muscle and the strap muscle were identified , we cut through the linea alba cervicalis incision with a harmonic scalpel between the strap muscles from the suprasternal notch to thyroid cartilage .
the general principle of surgical procedures for robotic total thyroidectomy was the same as conventional open thyroidectomy .
we should identify the tracheal wall , expose it as a midline landmark , and dissect the lower pole of thyroid from the adipose tissue or trachea . during this procedure
both thyroid lobes were exposed and examined for pathological changes , and with a strictly median orientation , the primary isthmus was removed using the harmonic scalpel .
the upper pole of the thyroid was drawn downward , and superior thyroid vessels were identified and individually divided close to the thyroid capsule to avoid injuring the external branch of the superior laryngeal nerve . during dissection , the superior parathyroid gland should be identified and left intact in situ [ figures 3 and 4 ] . identifying and protecting parathyroid glands and the recurrent laryngeal nerve .
robotic total thyroidectomy with central neck dissection showing the course of the ipsilateral ( right ) recurrent laryngeal nerve and the superior parathyroid gland .
the thyroid was retracted medially , and the middle thyroid vein was identified and coagulated off carefully .
careful dissection was performed to avoid the inferior thyroid artery and the recurrent laryngeal nerve ( rln ) .
we can easily identify and preserve the rlns under magnified 1015 times surgical view [ figures 3 and 4 ] .
after the inferior thyroid vein and thyrothymic ligament had been recognized , the thyroid was retracted upward and medially .
finally , proper application of the harmonic scalpel can successfully remove the thyroid gland from the trachea .
circular resection is recognized as a safe and highly effective method in robotic thyroidectomy via baba for bilateral thyroid lesions .
particular attention should be paid to ensure sufficient distance of the heated harmonic scalpel from the rln and the visible parathyroids .
we dissected the level 4 lymph nodes ( delphian / prelaryngeal , pretracheal , and paratracheal lymph nodes ) using the robotic system . during
ipsilateral or bilateral cnd , the lymph nodes of the central compartment were carefully dissected to avoid injuries to the rln and parathyroids .
application of carbon nanoparticles suspensions injection can stain the lymph nodes of the center compartment while leaving the parathyroid glands unstained ( because of the negative development of parathyroid glands to carbon nanoparticles , chongqing lummy pharmaceuticals , china ) , thus helping to identify and protect parathyroid glands and the rln [ figures 3 and 4 ] , as well as facilitating the identification and clearance of lymph nodes .
the resected specimen was extracted through enlarging the axillary skin incision by a specimen pouch .
vacuum - assisted draining system should be placed in the operative area though the axilla tunnel .
the wounds were closed with 5 - 0 absorbable monofilament sutures using an atraumatic needle , followed by placement of steri - strips .
conventional open approach patients in the conventional open approach group underwent conventional open total thyroidectomy with central lymph node dissection in the supine position with neck extension under general endotracheal anesthesia .
the lower layer of the platysma was cut through , and subplatysmal flap dissection was performed from the sternal notch to the level of the thyroid cartilage superiorly .
the linea alba cervicalis of the strap muscles was divided vertically , and the thyroid gland was exposed .
dissection of the thyroid and central lymph nodes was performed with harmonic focus ( ethicon endo - surgery inc . ,
, every effort was made to identify and preserve all parathyroid glands and the rlns with the negative development of parathyroid glands by carbon nanoparticles [ figure 5 ] .
parathyroid glands were transplanted in the sternocleidomastoid muscle once we found that the blood supply to the glands was compromised .
then , the surgical field was douched by 500 ml sterile distilled water ( 42c ) .
the wounds were closed by an atraumatic needle with 5 - 0 absorbable sutures . identifying and exposing recurrent laryngeal nerve , the negative development of parathyroid glands by carbon nanoparticles .
patients with no complications were usually discharged on day 3 to day 5 after the surgery .
for descriptive statistics of quantitative variables , mean  standard deviation ( sd ) and range were used to describe central tendency and dispersion . for analysis of the differences in proportions ,
fisher 's exact test was used if the assumptions of chi - square test were violated .
independent samples t - test was used to compare the level of quantitative variables between the two groups .
the clinicopathologic characteristics of 100 patients with papillary thyroid microcarcinoma are summarized in table 1 . the robotic total thyroidectomy with cnd
permanent pathological diagnosis showed that all 100 patients had papillary thyroid microcarcinoma . in the robotic group ,
mean time of creating workspace was 16.0  5.3 min , docking stage time was 10.5  3.2 min , and console stage time was 92.0  11.5 min .
the mean total operative time of the robotic group was longer than that of conventional open approach group ( 118.8  16.5 min vs. 90.7  10.3 min , p < 0.05 ) .
this study found the statistically significant differences between the two groups in terms of the vass for pain assessment ( 2.1  1.0 vs. 3.8  1.2 , p < 0.05 ) and nss ( 8.9  0.8 vs. 4.8  1.7 , p < 0.05 ) .
the differences of the two groups in the estimated intraoperative blood loss , postoperative hospital stay time , numbers of lymph node removed , primary tumor sizes , total drain volumes , mean draining days , and number of patients whose tumors showed multicentricity or multifocality were not statistically significant ( p > 0.05 ) . the complications in both groups , such as hypoparathyroidism ( temporary ) , rln paralysis ( temporary ) , seroma , skin burn , flap necrosis , hematoma , wound infection , chyle leakage , and postoperative tg levels , were not statistically different ( all p > 0.05 ) . among the 100 patients ,
35 ( 35% ) had subclinical central lymph node metastasis . the more patients ( 19 patients ) in robotic group had lymph node metastasis ( vs. 16 patients in conventional open approach group ) , but this did not influence the final results in the staging ( according to the american joint committee on cancer staging , 7 edition ) of both groups ( p > 0.05 ) . clinical data and postoperative outcomes between robotic and conventional open approach groups the data were shown as mean  standard deviation unless otherwise indicated .
bmi : body mass index ; cnd : central neck dissection ; rln : recurrent laryngeal nerve ; vas : visual analog scale ; nss : numerical score system ; tg : thyroglobulin .
postoperative cosmetic result was extremely satisfying in robotic group except one patient 's suprasternal fossa became shallow with minimal numbness and tingling [ figure 6 ] .
one patient in the robotic group experienced transient vocal cord palsy , but this resolved within 2 months without any treatment .
after the hoarseness had disappeared , we observed normal movement of the vocal cords by laryngoscope examination .
neither iatrogenic implantation nor metastasis occurred in punctured porous channel or chest wall was found by inspection or ultrasound during follow - up .
scar cosmesis 1 month after robotic total thyroidectomy with central neck dissection , which could be covered by bra .
the conventional surgical approach is to extend the incision into a large transverse incision to complete the required neck dissection . because the anterior neck is prominent and constantly exposed part of the body , an unsightly neck scars
furthermore , a majority of patients with papillary thyroid microcarcinoma are young women , who prefer no scar in the neck .
therefore , surgeons have made every effort to resolve the scar problem . in 1997 ,
the feasibility of robotic thyroidectomy with the transaxillary approach has been demonstrated by kang et al . in 2009 , which further improved the cosmesis .
the obvious advantage of the extracervical approach is the absence of visible scar in the neck or upper chest . according to anatomical access
, novel approaches such as postauricular and transoral approaches have been reported . to the best of our knowledge ,
some modified approaches have been reported in literature , which could be grouped into small cervical incisions , either the natural body orifice or the surface of the body ; the distant approaches such as the chest wall , periareolar , axillary , postauricular , and transoral ; and combined approaches .
all of the approaches have their own merits and drawbacks , such as the transaxillary approach is limited in arriving at the lymph nodes of the contralateral central compartment .
however , many reports have described the feasibility of thyroidectomy with robotic system for benign thyroid lesions .
some studies had reported that total thyroidectomy with prophylactic central lymph node dissection is necessary in patients with papillary thyroid microcarcinoma . for any new emerging technique ,
while tailoring the surgical approach to the patients concerns and desires is important , adhering to fundamental oncosurgical principles should always be a priority .
the subclinical central lymph node metastasis rate was 35% , and the rate of multicentricity or multifocality in papillary thyroid microcarcinoma was 15% .
this comparative study suggested that there were no significant differences regarding the oncological and the technical safeties between two groups .
robotic procedure uniquely provided a three - dimensional vision , the flexible robotic instruments with seven degree of freedom , and precise simulation - based technology .
these enabled surgeons to access deep , narrow spaces for a complete cnd and to identify and preserve the rln and parathyroid glands ( parathyroid gland autotransplantation : 10 in robotic group versus 16 in conventional open approach group , p > 0.05 ) .
however , robotic procedure is more invasive , more expensive , and more time - consuming than conventional open thyroidectomy .
however , the formation of visual thinking facilitated by robots can make up for the lack of tactile feedback .
robotic surgery could provide surgeons with the best opportunities to transform the thinking mode . in the future
, we intend to compare the long - term follow - up results and oncologic safety in a large sample size . according to the results of the study
the baba permits a full and symmetrical surgical view of important anatomic ( structures such as the superior and inferior thyroidal vessels , the rlns , the parathyroid glands , and the trachea ) , bilateral thyroid exploration , more workspace for instrument use , and the removal of larger nodules .
in terms of clinical safety and effectiveness , robotic total thyroidectomy with cnd was similar to open surgery .
however , some young women would refuse to receive this surgery since the baba would involve their breast .
further studies are needed to explore other better approaches to minimize this disadvantage . in conclusion ,
robotic total thyroidectomy with cnd via baba had same safety and effect as conventional open procedure for patients with papillary thyroid microcarcinoma , but its cosmetic effect was more satisfactory .
this study was supported by the grants from the third batch special foundation of china postdoctoral science foundation ( no .
201003759 ) , and the president funding of jinan military general hospital of pla ( no .
this study was supported by the grants from the third batch special foundation of china postdoctoral science foundation ( no .
201003759 ) , and the president funding of jinan military general hospital of pla ( no .
 background : a large proportion of the patients with papillary thyroid microcarcinoma are young women . 
 therefore , minimally invasive endoscopic thyroidectomy with central neck dissection ( cnd ) emerged and showed well - accepted results with improved cosmetic outcome , accelerated healing , and comforting the patients . 
 this study aimed to evaluate the safety and effectiveness of robotic total thyroidectomy with cnd via bilateral axillo - breast approach ( baba ) , compared with conventional open procedure in papillary thyroid microcarcinoma.methods:one-hundred patients with papillary thyroid microcarcinoma from march 2014 to january 2015 in jinan military general hospital of people 's liberation army ( pla ) were randomly assigned to robotic group or conventional open approach group ( n = 50 in each group ) . 
 the total operative time , estimated intraoperative blood loss , numbers of lymph node removed , visual analog scale ( vas ) , postoperative hospital stay time , complications , and numerical scoring system ( nss , used to assess cosmetic effect ) were analyzed.results:the robotic total thyroidectomy with cnd via baba was successfully performed in robotic group . 
 there were no conversion from the robotic surgeries to open or endoscopic surgery . 
 the subclinical central lymph node metastasis rate was 35% . 
 the mean operative time of the robotic group was longer than that of the conventional open approach group ( 118.8  16.5 min vs. 90.7  10.3 min , p < 0.05 ) . 
 the study showed significant differences between the two groups in terms of the vass ( 2.1  1.0 vs. 3.8  1.2 , p < 0.05 ) and nss ( 8.9  0.8 vs. 4.8  1.7 , p < 0.05 ) . the differences between the two groups in the estimated intraoperative blood loss , postoperative hospital stay time , numbers of lymph node removed , postoperative thyroglobulin levels , and complications were not statistically significant ( all p > 0.05 ) . 
 neither iatrogenic implantation nor metastasis occurred in punctured porous channel or chest wall in both groups . 
 postoperative cosmetic results were very satisfactory in the robotic group.conclusions:robotic total thyroidectomy with cnd via baba is safe and effective for chinese patients with papillary thyroid microcarcinoma who worry about the neck scars . 