ectopic thyroid tissue is a common abnormality and results from abnormal embryologic development and migration of the thyroid gland .
such tissue is usually found along the path of descent of the thyroid gland in the anterior midline of the neck .
a lingual thyroid is the most common presentation of thyroid ectopy   along with thyroglossal duct remnants .  
ectopic thyroid tissue has been described in other parts of the head and neck such as the submandibular [ 3 , 4 ] and parotid salivary glands .
there are case descriptions of thyroid tissue identified in diverse locations such as the axilla , trachea [ 710 ] , adrenal , small intestine , and porta hepatis .
the most frequent noncervical location for ectopic thyroid tissue is the thoracic cavity [ 1418 ] .
, the authors describe a case of ectopic anterosuperior mediastinal thyroid mass excised through a cervical incision and the subsequent investigation to exclude malignancy .
an 80-year - old nonsmoker female patient presented with an incidental finding of a mediastinal mass on mri scan for investigation of vertigo ( figures 1 and 2 ) .
thyroid stimulating hormone ( tsh ) and free thyroxine ( ft4 ) were within the normal range , and routine preoperative blood tests were normal .
an anteroposterior chest radiograph demonstrated deviation of the intrathoracic trachea around the mass ( figure 3 ) . a subsequent ultrasound scan demonstrated a superior mediastinal mass separate from the inferior pole of the right thyroid lobe measuring 4.8  cm in maximal diameter ( figure 4 ) .
the first sample was inadequate ( thy1 ) , the second sample demonstrated only colloid and a few follicular cells .
since malignancy could not be definitively ruled out , the mass was excised through a cervical incision .   under general anesthesia , the patient was placed in the supine position with the neck extended , prepared , and draped .
endotracheal laryngeal nerve monitoring was used with nim contact emg endotracheal tube and nim - response 2.0 monitor ( medtronic usa , inc.6743 southpoint drive north , jacksonville , florida , usa , 32216 - 0980 ) . through a standard 5  cm midline cervical incision
, the right thyroid lobe was dissected , found to be grossly normal , and excised .
the right recurrent laryngeal nerve was identified in the normal position , confirmed functioning with nerve stimulation at 2  ma , and preserved .  
separate and inferior to the right thyroid lobe a discrete encapsulated mass was identified in the superior , mediastinum .
this extended across the anterior surface of the trachea to the left side , adjacent to the thymus .
the mass was separated from the thyroid gland by fat , in the same tissue plane but with no identifiable connection to the cervical region .
the mass was excised through the cervical incision . during excision of the mass , a double vascular pedicle , arising from inferiorly in the mediastinum ,
histopathologic evaluation of the excised mediastinal specimen demonstrated a 5.3  cm by 2  cm thyroid tissue mass with large oedematous loose areas and foci of calcification and fibrosis ( figure 5 ) .
the excised right thyroid lobe had a nodular architecture composed of follicles of varying sizes with focal lymphoid aggregates.thyroid function tests at 3 months were normal .
further investigation with whole body radioiodine i123 scintigraphy demonstrated expected residual uptake in the remaining left thyroid lobe and surgical bed but no uptake suggestive of other ectopic thyroid tissue or metastatic disease .
ultrasound surveillance of a 9  mm nodule in the remaining left lobe demonstrated no change in size over 6 months .
in humans , the thyroid gland begins to develop at the 24th day of gestation .
the thyroid is the first endocrine gland to develop and originates from between the first and second branchial arches .
an invagination of endodermal epithelial cells begins at the midline of the developing pharyngeal floor forming a diverticulum .
this site , known as the foramen caecum , lies between the tuberculum impar ( median tongue bud ) and the hypobranchial eminence ( copula ) .
the foramen caecum can be observed in adults as a small pit at the base of the tongue where the tongue is divided into an oral anterior two - thirds and pharyngeal posterior third by the sulcus terminalis .
the initial path of descent of the bilobed thyroid diverticulum is anterior to the pharyngeal gut , the hyoid bone , and the laryngeal cartilages . at the same time
embryological studies have shown that the strap muscles pull downward on the hyoid bone during development causing a forward tilt .
this tilt pulls the tract posteriorly and causes it to be hooked up behind the hyoid bone .
this explains the importance of excision of the median portion of the hyoid bone in the sistrunk procedure to excise a thyroglossal duct cyst .  
the gland reaches its final location anterior to the trachea by the 7th week gestation . by this stage , it has acquired a median isthmus and two lateral lobes .
as it descends , it is joined by the ultimobranchial bodies which form the parafollicular c cells .
thyroid function begins at around the end of the 3rd month when the follicular cells commence production of colloid and follicles appear .   during migration , from the 5th week gestation
, the thyroid is still connected to the tongue by the thyroglossal duct . in normal development , this tubular structure subsequently obliterates entirely at approximately the 8 to 10th week . in some individuals , however , abnormalities in the embryologic development and migration of the thyroid gland can result in ectopic thyroid tissue .
these remnants can appear at any point along the migratory path and are always located at or near the midline .
the majority of remnants are found at , or just inferior to , the body of the hyoid bone as a thyroglossal cyst .
remnants can also be found in the tongue base as a lingual thyroid or close to the thyroid cartilage .
the inferior end of the thyroglossal duct may fail to obliterate , and in at least half of individuals , a pyramidal lobe of the thyroid can be seen to persist .
this pyramidal lobe itself may be attached to the hyoid bone or may be incorporated into a thyroglossal duct cyst .
ectopic thyroid tissue in other locations is rare and generally the subject of single case reports .
the most important diagnosis to exclude is metastatic lymph node deposits of well - differentiated thyroid carcinoma .
indeed , it is generally accepted that early reports of  lateral aberrant  thyroid tissue may represent papillary thyroid carcinoma metastases .
another hypothesis is that a thyroid nodule may become detached from the gland . in this case
, the vascular supply should come from branches of the superior or inferior thyroid artery .
there are reports of thyroid deposits in the soft tissues of the neck representing surgical implantation of thyroid neoplasms . in one case ,
infiltrating thyroid tissue in muscle and fibrous tissue presented 3 years after major blunt trauma to the neck .
the tissue resembled that in a disrupted thyroid nodule present in the gland itself and was regarded as traumatically implanted .
there are , however , a number of ectopic thyroid masses reported which do not have features consistent with these theories and are considered truly developmental .
animal studies suggest that ectopic location of thyroid tissue may be related to vascular development .
the normal arterial supply of the thyroid gland consists of paired superior and inferior thyroid arteries . the superior thyroid artery is generally considered to be present in 100% of cases , and its absence has only been reported once . an unusually large superior thyroid artery may replace the contralateral vessels or the inferior thyroid artery .
the inferior thyroid artery when unusually small or absent may be replaced or supplemented by a thyroidea i m a artery .
published reports place the incidence of a thyroidea i m a artery   between 2% and 12% .   in the case
the ectopic mass was separate from the thyroid gland but in the same anatomical plane .
careful histological examination of the mass and the excised ipsilateral thyroid lobe demonstrated no evidence of neoplasia , and exhaustive investigations showed no evidence of thyroid malignancy elsewhere .
the authors therefore conclude that this represents developmentally ectopic sequestered thyroid tissue in the anterior mediastinum . despite this
, the authors suggest that abnormally situated thyroid tissue , other than that in the central neck along the path of embryological descent of the thyroid gland , should be excised for careful histological analysis in order to exclude metastatic disease .
 an 80-year - old female presented with an incidental finding of a retrosternal mass on magnetic resonance imaging . 
 ultrasound demonstrated a mediastinal lesion adjacent to but separate from the inferior pole of the right thyroid lobe . 
 fine needle aspiration cytology demonstrated colloid and follicular cells . at surgery 
 , the right thyroid lobe was found to be normal . 
 a discrete 5 cm nodule was found in the anterior mediastinum separate from the thyroid and just anterior and to the right of the trachea and thymus . 
 the nodule had a vascular pedicle arising from the mediastinum . 
 the differential diagnosis included metastatic thyroid carcinoma . 
 histology was consistent with a benign ectopic sequestered thyroid nodule . 
 extensive investigations demonstrated no sign of a thyroid malignancy . 