atepeq/tico19 huggingface dataset:
The vaccine candidate was developed within 14 days of receiving the sequence from China.
K` cuu kvn w`l g1x ju1th in caa kuany t`th rvy n5n5 14 kv ksr k` m22 c5 kvn ku2y j55n5kv kvr7 jek k` Cvyna.
In late March, the Canadian government announced C$275 million in funding for 96 research projects on medical countermeasures against COVID-19, including numerous vaccine candidates at Canadian companies and universities, such as the Medicago and University of Saskatchewan initiatives.
Kv guut pay d5]k, cuu kuumv j5 Kvnvdv jv lat5 cv y57w t55 bathdssr5 t5 C$275 k1m p5rsjvkn5 g7r` x`c` t5 96 kv ku5c l`tn5 du2l w1l tin caa k1n kv g1x COVID-19, t5 te ksmpvn5n5 j5 Kvnvdv t5 xuan t5 caa kuany kv t1th w1l g1x ju1th th5n am`n5 Yun5b7rth5t5n5, cetkv Med5kag6 kvnv Yun5b7rth5t5 Saskatchewan min c5 rs kuany.
Around the same time, the Canadian government announced C$192 million specifically for developing a COVID-19 vaccine, with plans to establish a national "vaccine bank" of several new vaccines that could be used if another coronavirus outbreak occurs.
kv jvn gu11th vms cu kuumv Kvnvda jv lar 5 k5thn5 C$ 192, kv cu]]p w1l COVID-19, kv c1p l1t bvx` w1l tum` t5 pay l1t t5 g66l dee naath lv l`t kv kv ksrsnabayr`th d]divn in dee lv tusk.
On 2 April 2020, researchers at the University of Pittsburgh School of Medicine reported on testing of PittCoVacc, a possible COVID-19 vaccine in mice, stating that "MNA delivered SARS-CoV-2 S1 subunit vaccines elicited potent antigen-specific antibody responses [in the mice] that were evident beginning 2 weeks after immunization."
kv pay xuaan 2 2020, g66r x`c` k` Yunib5thvt5 Pttsburg dueelwal cua jv lar v kvn kv th2m PittsCoVacc, 5 w1k tum` COVID-19 k` kun, ku2nx jv piny 5 “MNA in n66x SARS-CoV-2 s1 jv min la pek pstvn antigene v civk kv antibody [k` kun] min la nyuuth tookv k` juskn5 2 kv ksr th7p` bum` pu11ny.
In Canada on 16 April 2020, the University of Waterloo School of Pharmacy announced design of a DNA-based vaccine candidate as a possible nasal spray.
K` Ksnsda kc c`x k` 6 pay xuaan 2020, Yun5b7thvt5 Waterloo duel t1th wal cuv jv lar 5 w`l m5 c``t DNA derv gsaa kv du`c wuum.
Using bacteriophages, the DNA will be designed to replicate inside human bacteria to produce harmless virus-like particles, which may stimulate the immune system to produce antibodies against the SARS-CoV-2 virus.
L1t kv bact5ri6pvjn5, vn DNA ba l1t bv bact5ria r0i ran we jak` xuan b5 b5 p1rt5ksl` bayr`th` m5 thil luex dieth, m5 b5 bu]m pu11ny jiac nhial kv l1tdv antibody n5 t5 nyieny kv bayr`th SARS-CoV-2.
In March 2020, the US government, industry, and three universities pooled resources to access supercomputers from IBM, combined with cloud computing resources from Hewlett Packard Enterprise, Amazon, Microsoft, and Google.
Kv pay di]k 2020, cu kuumv US, yind1tjhtvr5, kvn Yunvb7thvt5n5 di]k kuak k`m raar kv g6r ksmpi7tvr` min d55t IBM, in ca mat kvn kuak kslssd ksmpi7tvr k` Hewlett pakcard interp5raath, amdhsn, mayksr6thspt kvn g6gil.
Some vaccines have heterologous effects, also called non-specific effects.
Th11x wal tum` te kvn kv ciaax m5 gu1c, m5 csal kv b` 5 /ci ciaax kvl.
That means they can have benefits beyond the disease they prevent.
M5 lotn5 f66 dee kvn te kv gssy m5 b``l juey in ku kvnv lv gax.
A further randomized trial in Australia is seeking to enrol 4,170 healthcare workers.
F]]n d]divn k` Sthtrvr6lia g77rv g]r piny k5mn5 t5 4,170.
It is possible vaccines in development will not be safe or effective.
L1t w1lv min lot rs kv jv /cv b5 gsaa kiv l`t.
Early research to assess vaccine efficacy using COVID-19-specific animal models, such as ACE2-transgenic mice, other laboratory animals, and non-human primates, indicate a need for biosafety-level 3 containment measures for handling live viruses, and international coordination to ensure standardized safety procedures.
G6r x`c` m5 nhiam n5 wal kv jek w1l kv l1t COVID-19 kv c1p m5 cop ley, cet kv ACE2 kv g2r j55n` ku]n, th22mn5 lab k]kivn kv ley, kvn gsakn5 tin /c5 t] a naath, nyyoth g6r gssy` t22k` kv k1th m5 3 kv th2m tin ba l`t bayr`th m5 t2k, kvn l1t wec mu]]n kvvl kv g6r gssy` yithtandvrdaath` dupn5 tin l1t jv.
Vaccines against SARS and MERS have been tested in non-human animal models.
Wal tin nyieny kv SARS kvn MERS ca kv f]n kv ley t5 /c5 t] a naath.
As of 2020, there is no cure or protective vaccine for SARS that has been shown to be both safe and effective in humans.
Kv gu11th m5 cet kv 2020, thilv w1l m5 jooc kiv gax SARS m5 ca n5 nyoth 5 gsaa k` l`t k` ley.
According to research papers published in 2005 and 2006, the identification and development of novel vaccines and medicines to treat SARS was a priority for governments and public health agencies around the world.There is also no proven vaccine against MERS.
Wargak g7r` `x`c` m5 c5 ben raar kv 2005 kvn 2006, vn n2n kvn l1t w1l in rvl rs kv tu]m SARS cua jvn la nhiams k` kuumvn5 vkn gu1th pusl` pu11ny w55 mu]]n kvvliw. Thilv w`l m5 thu]k kv ku5c MERS.
When MERS became prevalent, it was believed that existing SARS research may provide a useful template for developing vaccines and therapeutics against a MERS-CoV infection.
M22 c5 MERS fsw kith, cua jv x`th 5 g6r x`c` min wen k` SARS d]x bv naath lu`k kv l1t w1l kv thvrapeutikn5 kv ku5c luex` MERS-CoV.
As of March 2020, there was one (DNA based) MERS vaccine which completed phase I clinical trials in humans, and three others in progress, all of which are viral-vectored vaccines, two adenoviral-vectored (ChAdOx1-MERS, BVRS-GamVac), and one MVA-vectored (MVA-MERS-S).
Kv pay di]k 2020, cuv te kv w1l MERS kvl m5 l1t kv DNA m5 cu f]]n kvl p11th kv l1t w1l k` naath, k` di]k k]kivn v dup, kvn diaal kv wal bvktsr bayrsl , adenobayrsl bvktsr (ChAdOx1-MERS, BVRS-GamVac), kvn kvl MVA-bvktsr (MVA-MERS-S).
Social media posts have promoted a conspiracy theory claiming the virus behind COVID-19 was known and that a vaccine was already available.
Gu11th l``r5 nath diaal tin pu1t kv ca c1p g66ny` kap nhial m5 laar f66 bayr`th in took COVID-19 x1c jv 5 k` te w`lv th5n n5 wen.
The patents cited by various social media posts reference existing patents for genetic sequences and vaccines for other strains of coronavirus such as the SARS coronavirus.
Tin lat kvn gu`th l``r5 diaal kv kv pu]tdivn kv min caar kvnv kv min lat kvnv kv tuk guur5 wal kv p6r rivm tin k]x k` bayr`th cet kv SARS ksrsnabayr`th.
b'Coronaviruses are a group of related viruses that cause diseases in mammals and birds.
b’Ksrsnabayr`thn5 kv bu]n m5 c``t t5 n66x juey k` ley caak kvn diit.
In humans, coronaviruses cause respiratory tract infections that can range from mild to lethal.
K` naath, ksrsnabayr`th n77xv luex ju1th l55k` m5 dee ku00 k` dee d5t.
Mild illnesses include some cases of the common cold (which has other possible causes, predominantly rhinoviruses), while more lethal varieties can cause SARS, MERS, and COVID-19.
Juey m5 tst kvvl kvn th11x thony-thony` (m5 te kv tuk d]divn , vl]x rin66bayr`th), k` min d55tdv derv SARS, MERS kvn COVID-19 n66x.
Symptoms in other species vary: in chickens, they cause an upper respiratory tract disease, while in cows and pigs they cause diarrhea.
Nyuuthn5 kv k` kuay tin k]x gu1c kv: k` manpal00k, n77xv juey nhial l55k`, k` f]k kvn kundhur5 n77x kvn c5th.
There are yet to be vaccines or antiviral drugs to prevent or treat human coronavirus infections.
Xot wal kiv antibayral5 tin d22 gaxv kiv d22 tom luex ksrsnabayr`th k` raan.
Coronaviruses constitute the subfamily Orthocoronavirinae, in the family Coronaviridae, order Nidovirales, and realm Riboviria.
Ksrsnabayr`thn5 kv dhsr Srthsksrsnabay5nia, rvi dhsaar Ksrsnabayr5dia, luey N5dobayralith kvn k1th Rayb6bayria.
They are enveloped viruses with a positive-sense single-stranded RNA genome and a nucleocapsid of helical symmetry.
Kvn kum bayr`thn5 kv kv RNAgensme kvl kvn nukvli6capthid hel5kal th5m5t5r5.
The genome size of coronaviruses ranges from approximately 26 to 32 kilobases, one of the largest among RNA viruses.
Vn pek gensme ksrsnabayr`th thi``xv kam 26 v we k` 32 k5l6bvth, kvl m5 d55t k` RNA bayr`thn5.
They have characteristic club-shaped spikes that project from their surface, which in electron micrographs create an image reminiscent of the solar corona from which their name derives.
Te kvn kv ciaax ks jsac luak` m5 jivn w55divn, m5 rvi mayk7r7g5r1pn5 tookv thurv m5 cet kv ksrsna c1x in b` ci66kivn th5n.
Coronaviruses were first discovered in the 1930s when an acute respiratory infection of domesticated chickens was shown to be caused by infectious bronchitis virus (IBV).
Ksrsnabayr`thn5 n0n kv kv nhiam kv 1930 m22 ca luex l55k` manpa00k m5 rup-rup nvn 5 n77xv luex bsrsxkayt5th bayr`th (IBV).
In the 1940s, two more animal coronaviruses, mouse hepatitis virus (MHV) and transmissible gastroenteritis virus (TGEV), were isolated.Human coronaviruses were discovered in the 1960s.
Kv 1940, rvw k` ley, bayr`th g7r` mieth k` kun (MHV) kvn bayr`th ji`c` m5 la dsap kv (TGEV), cua kv nvn. Ksrsnabayr`thn5 ran n0n kv kv kv 1960.
The earliest ones studied were from human patients with the common cold, which were later named human coronavirus 229E and human coronavirus OC43.
T22 nhiam t22 ksax guic kv k` naath t5 j5 ju1th t5 te kv thony-thony t22 ca ben csl 5 ksrsnabayr`th ran 229E kvn ksrsnabayr`th ran AC43.
They were first imaged by Scottish virologist June Almeida at St. Thomas Hospital in London.
Cua kv nvn kv nhiam v bayrslsj5th Yithkst n5 June Almeida du22lw1l thvnt Tsmvth k` London.
Other human coronaviruses have since been identified, including SARS-CoV in 2003, HCoV NL63 in 2004, HKU1 in 2005, MERS-CoV in 2012, and SARS-CoV-2 in 2019.
Bayr`thn5 ran tin k]x cua kv ku we kv m5 n0n kv kv, tin te rvidivn kv SARSCoV kv 2003, HCoV NL63 kv 2004, HKU1 kv 2005 MERS-CoV k 2012, kvn SARSCoV-2 kv 2019.
Most of these have involved serious respiratory tract infections.
R5wdivn kvn titi c5 luex ju1th l55k` n66x.
The name was first used in 1968 by an informal group of virologists in the journal Nature to designate the new family of viruses.
Vn ci6t lar kv nhiam k` 1968 v bu]n bayrslsj5th m5 nyun-nyun rvi wargak` n2cvr kv nyu]th dhsaar bayr`thn5.
The name refers to the characteristic appearance of virions (the infective form of the virus) by electron microscopy, which have a fringe of large, bulbous surface projections creating an image reminiscent of a crown or of a solar corona.
Vn ci6tdivn naxv rs ciaax bayri6n (kv t`` luex` bayr`th`) v ilvktsrsn mayksrsthksp5, m5 te kv bivvl t5 d5t, m5 rox-rox kv thurv thaac kiv ksrsna c1x.
This morphology is created by the viral spike peplomers, which are proteins on the surface of the virus.
Jsac vmv n77xv luak pepilsmvr5th bayrsl, t5 la psrstiin w55 bayr`th`.
Coronaviruses are large pleomorphic spherical particles with bulbous surface projections.
Ksrsnabayr`thn5 kv p1rt5ksl5 pili6msrpikn5 jsam t5 te kv w5c m5 rox-rox.
The envelope of the virus in electron micrographs appears as a distinct pair of electron dense shells.The viral envelope consists of a lipid bilayer where the membrane (M), envelope (E) and spike (S) structural proteins are anchored.
Vn kuumdv vn bayr`th rvi ilvktsrsn mayksr6g5r11pn5 jscv v la k7tn5 rvw t5 g66l k` cok. Vn kuum bayrsl t22 kv thisl kv keer5 rvw tin g6l m`mbvr1n (M), kuum (E), kvn psrstiin luak` min d55t (S).
The lipid bilayer envelope, membrane proteins, and nucleocapsid protect the virus when it is outside the host cell.
Vn kuumn5 thiaal d1x rvw, psrstiin m`mbvr1n, kv nukili6kapthid gax kvn bayr`th m5 cv ben raar rvi gu1th civvx`dv.
Coronaviruses contain a positive-sense, single-stranded RNA genome.
Ksrsnabayr`thn5 te kv kv RNA gensme kvl.
The genome size for coronaviruses ranges from 26.4 to 31.7 kilobases.
Vn pek gensme k` ksrsnabayr`thn5 naxv rs kam 26.4 v we k` 31.4 k5l6b`thn5.
The genome size is one of the largest among RNA viruses.
Vn pek gensme v kvl m5 d55t k` RNA bayr`thn5.
The open reading frames 1a and 1b, which occupy the first two-thirds of the genome, encode the replicase/transcriptase polyprotein.
Vn ku2n in f66x kv kex 1a kvn 1b, in thi``x kamin nhiam 2/3 k` gensnome, t]]wv r5pl5k22th/tiranithkiript`th psl5psrstiin.
The replicase/transcriptase polyprotein self cleaves to form nonstructural proteins.The later reading frames encode the four major structural proteins: spike, envelope, membrane, and nucleocapsid.
Kvn pu1ny r5pl5k22th/tiranithkiript`th psl5psrstiin la coxv v bv ben v la m5 thil psrstiin m5 n0n kv. %yss kuendv bv kex xuaan nyoth t5 jsc psrstiin: kuum luak`, m`mbvr1n, kvn nuk5l5kapthid.
Interspersed between these reading frames are the reading frames for the accessory proteins.
Min ku r6m kam ku2n5 d1x rvw titi kv kexkivn kv g22l5 psrstiin.
The number of accessory proteins and their function is unique depending on the specific coronavirus.
kvn pek g22l5 psrstiin kvn l1tkivn c``t kv k` ksrsnabayr`th kvl in ca bir.
Infection begins when the viral spike (S) glycoprotein attaches to its complementary host cell receptor.
Luex la tusskv min c5 luak bayrsl (S) g5layk6psrstiin rv dsap th0l l== in payv jek gu22r.
After attachment, a protease of the host cell cleaves and activates the receptor-attached spike protein.
Kv ksr k` min cv rs dsap th5n, b5 psrstiaath t0l l== indan rs cu ti11c k` bv thi22pdv jak` l5p bv c5 mat kvn psrstiin luak`.
Depending on the host cell protease available, cleavage and activation allows the virus to enter the host cell by endocytosis or direct fusion of the viral envelop with the host membrane.On entry into the host cell, the virus particle is uncoated, and its genome enters the cell cytoplasm.
K` t11 psrstiaath th0l` l== v thi`ks, thieek kvn l1t bv bayr`th cu jak` we rvi th0l` l== kv ind6thayt6thith kiv kv r6m m5 civk kvn kuum bayrsl kvn m`mbvr1n l==. Kv wedv rvc k` ley, vn p`rt5ksl bayrsl ba pusth, k` gensmednv bv cu coth k` th0l thayt6p5l1thdh5m.
The host ribosome translates the initial overlapping open reading frame of the virus genome and forms a long polyprotein.
Vn rayb6thsm l== bv mat kuen` kexn5 bayr`th` gensme min nhiam kvn k` bv psl5psrstiin m5 b``r cu l1t.
The polyprotein has its own proteases which cleave the polyprotein into multiple nonstructural proteins.
Vn psl5psrstiin t22 kv psrstiaathdv m5 la cox psl5psrstiin k` psrst55n5 t5 xuan t5 thil t11 m5 com.
A number of the nonstructural proteins coalesce to form a multi-protein replicase-transcriptase complex (RTC).
Pek psrstiin5 t5 thil t`` m5 com bv kv rs mat b5 kv psrstiin5 t5 xuan repl6k`th-transk5r5pt`th (RTC)m5 d55t cak.
The main replicase-transcriptase protein is the RNA-dependent RNA polymerase (RdRp).
Vn psrstiin repl6k`th-transk5r5pt`th` in d55t v cuxv jsk RNA RNA psl5mvr`th (RdRp).
It is directly involved in the replication and transcription of RNA from an RNA strand.
Jvn matv rs rvi lc` v civk kvn lu]c RNAk` ben RNA piny.
The other nonstructural proteins in the complex assist in the replication and transcription process.
Kvn psrstiin5 tin k]x tin thil nen m5 com rvi mat` ms d55ts lu`k kvn du]]p in loc xsak rs kv jv.
The exoribonuclease nonstructural protein, for instance, provides extra fidelity to replication by providing a proofreading function which the RNA-dependent RNA polymerase lacks.One of the main functions of the complex is to replicate the viral genome.
Vn ikdhraybsnuk5livth psrstiin in thil n2n mi com, jvn n77xv gssy luc` m5 d]x kv n77xdv kv l1t gssy` kuen` min cux RNA jskdv min thil RNA psl5mvr`th. Kvl k` l`t ksmp5l=k in d55t v lu]c gensme bayrsl`.
RdRp directly mediates the synthesis of negative-sense genomic RNA from the positive-sense genomic RNA.
RdRp v civk la c1k nvkvtip thvn RNA gensme v b77thv k` pu]thvtip thvn RNA gensme.
This is followed by the replication of positive-sense genomic RNA from the negative-sense genomic RNA.
Vnv ba jv gu]]r v lu]c pu]thvtip thvn RNA gensme k` nvkvtip thvn RNA gensme.
The other important function of the complex is to transcribe the viral genome.
Vn l1t d]x in bum k` min d55t v tu1nithkirip bayrsl gensme.
RdRp directly mediates the synthesis of negative-sense subgenomic RNA molecules from the positive-sense genomic RNA.
RdRpv civk la c1k nvkvtip thvn RNA gensme v b77thv k` th11x RNA gensme.
This is followed by the transcription of these negative-sense subgenomic RNA molecules to their corresponding positive-sense mRNAs.
Vn ba jv gu]]r v tu1nithkiripcin nvktip thvn th11x RNA mslski77l` v we k` pu]thvtip thvn mRNAn5.
The replicated positive-sense genomic RNA becomes the genome of the progeny viruses.
Vn lu]c pu]thvtip RNA gensme bv ben v la gensme psrsjen5 bayr`th`.
The mRNAs are gene transcripts of the last third of the virus genome after the initial overlapping reading frame.
Vn MRNAn5 kv tu1nithkirip j55n` min jsak in di]]k gensme bayr`th` kv ksr mat` kex` kuen` min nhiam.
These mRNAs are translated by the host's ribosomes into the structural proteins and a number of accessory proteins.
Kvn mRNAn5 titi la loc raybsn5 l== kv k` psrstiin m5 te kv pu]ny m5 com kvn pek g``xn5 psrstiin` t5 lvm.
RNA translation occurs inside the endoplasmic reticulum.
Lu]c RNA la tusskv rviind6pl1thmik rvkt5kul1m.
The viral structural proteins S, E, and M move along the secretory pathway into the Golgi intermediate compartment.
T11 pu11ny psrstiin bayrsl S, E, kvn M la j`l kv kvvl kv thuny du]p we kv rvi Gslg5 kam ca d11k k` bun.
There, the M proteins direct most protein-protein interactions required for assembly of viruses following its binding to the nucleocapsid.
Vn w5n5, vn psrstiin M bv l1t kvvl kam psrstiin5 b7th in g6r kv mat bayr`thn5 kv ksr li6mdivn kv nuk5li6kapthid.
Progeny viruses are then released from the host cell by exocytosis through secretory vesicles.
Bayr`thn5 psrsjvn5 ba kv j1k raar pu]]ny th0l5 l== v vkdhsthayt6thith kv dup thuny`.
The interaction of the coronavirus spike protein with its complement host cell receptor is central in determining the tissue tropism, infectivity, and species range of the virus.
L1t kvvl luak` ksrsnabayr`th kvn th0l5 l== in t22 pu]]nydv v jvn la min nhiams kv tsrp5dh5m` t5cuun5, luexdv, kvn xuan ku00n5 bayr`th`.
The SARS coronavirus, for example, infects human cells by attaching to the angiotensin-converting enzyme 2 (ACE2) receptor.
Vn SARS ksrsnabayr`th, c``t, la luvvxv th=l5 ran kv dspdv k` axji6tenthin in la r55t thieepn5 yindham 2 (ACE2).
The scientific name for coronavirus is Orthocoronavirinae or Coronavirinae.
Vn ci6t tanytith` ksrsnabayr`th v Srthksrsnbayr5naia kiv ksrsnbayr5naia.
Coronaviruses belong to the family of Coronaviridae, order Nidovirales, and realm Riboviria.
Ksrsnbayr`th t22 dhsr Ksrsnar5dia, k1th N5dsbayrslith, kvn kam Raybsbayria.
Genus Betacoronavirus; type species: Murine coronavirus
J5n`th Betaksrsnabayr`th, Kuay kv: Muriin ksrsnabayr`th
Species: Betacoronavirus 1 (Bovine Coronavirus, Human coronavirus OC43), Human coronavirus HKU1, Murine coronavirus, Pipistrellus bat coronavirus HKU5, Rousettus bat coronavirus HKU9, Severe acute respiratory syndrome-related coronavirus (SARS-CoV, SARS-CoV-2), Tylonycteris bat coronavirus HKU4, Middle East respiratory syndrome-related coronavirus, Hedgehog coronavirus 1 (EriCoV)
kuay kv: Betaksrsnabayr`th 1 (Bsbaan Ksrsnabayr`th, Ksrsnabayr`th ran OC43), Ksrsnabayr`th ran HKU1, Muriin ksrsnabayr`th, Pipithtvrvll1th ksrsnabayr`th xap` HKU5, Ruuthvt1th ksrsnabayr`th xap` HKU9, Ksrsnabayr`th l55k` min rup-rup (SARS-CoV, SARSCoV-2), Taylsn5tvrith ksrsnabayr`th xap` HKU4, Ksrsnabayr`th d11r cu22c fsaa in n77x juey l55k`, Hej5hsg Ksrsnabayr`th 1 (EriCoV).
Species: Beluga whale coronavirus SW1, Infectious bronchitis virus
Kuay kv: Begula ksrsnabayr`th Wvvl SW1, Bayr`th bsrskayt5th in pu]ny luex
The most recent common ancestor (MRCA) of all coronaviruses is estimated to have existed as recently as 8000 BCE, although some models place the common ancestor as far back as 55 million years or more, implying long term coevolution with bat and avian species.
Gu1ndssxdivn in pay jek (MRCA) kvn bayr`thn5 diaal ca jv diw 5 t22 th5n n5 kv gu11th thi1kv kv 8000BCE, c`x min l`th th11x guec jv 5 gu1ndssxdivn diaal t22 th5n n5 kv run t5 bathdssr5 t5 55 kiv v we nhiam, nyooth lu]c m5 c5 gu11th nax k` xap kvn kuay din.
The most recent common ancestor of the alphacoronavirus line has been placed at about 2400 BCE, the betacoronavirus line at 3300 BCE, the gammacoronavirus line at 2800 BCE, and the deltacoronavirus line at about 3000 BCE.
Keer gu1ndssx alphaksrsnabar`thn5 diaal ca jv l1th k` 2400 BCE, vn keet betaksrsnabayr`th t22 th5n kv 3300 BCE, vn keer gammaksrsnabayr`th t22 th5n kv 2800 BCE, k` keer deltaksrsnabayr`th t22 th5n kv 3000 BCE.
The large number of host bat and avian species, and their global range, has enabled extensive evolution and dissemination of coronaviruses.Many human coronavirus have their origin in bats.
Pek in d55t k` let tin civxv pu]nydivn xap kvn diit, kvn fsw in civk kvnv, cv kv lu`k kvn ksrsnabayr`thn5 kv lu]cdivn kv rs kv gu11th m5 b``r. Ksrsnabayr`thn5 ran t5 xuan tussk kvn k` xapn5.
More recently, alpaca coronavirus and human coronavirus 229E diverged sometime before 1960.
Kv gu11th m5 thi1k, alpa ksrsnabayr`th kvn ksrsnabayr`th ran 229E cuv d`k piny kv gu11th v xot 1960.
MERS-CoV emerged in humans from bats through the intermediate host of camels.
MERS-CoV tusskv k` raan b22 k` xap kv jamvl kvn ley in tusskv pu]]nydv.
MERS-CoV, although related to several bat coronavirus species, appears to have diverged from these several centuries ago.
MERS-CoV, c`x min c``tv kv kuay ksrsnabayr`thn5 xap` tin k]x, jscv 5 cv d`k piny kvk kv kv run t5 xuan t5 c5 we.
The most closely related bat coronavirus and SARS-CoV diverged in 1986.
Ksrsnabayr`th xap` min c``t kv SARS-CoV d`k kvn piny kv 1986.
A possible path of evolution, of SARS coronavirus and keen bat coronaviruses, suggests that SARS related coronaviruses coevolved in bats for a long time.
Du]]p ksrsnabayr`th SARS-CoV in lussc kv jv kvn kvvn ksrsnabayr`th xap`, nyyothv jv 5 ksrsnabayr`thn5 tin c``t kv SARS tussk lusscdivn kvvl kv 1986.
In the 1790s, equine coronavirus diverged from the bovine coronavirus after a cross-species jump.
Kv run 1970 n5, ksrsnabayr`th ciex man mu]l cuv d`k piny kvn ksrsnabayr`th ciex man yaax kv ksr kv me c5 kuay gu1c.
Later in the 1890s, human coronavirus OC43 diverged from bovine coronavirus after another cross-species spillover event.
Kv jsak kv 1890 n5, ksrsnabayr`th ran OC43 cuv d`k piny kkv ksrsnabayr`th ciex man yaax kv ksr gu1c` kuayn5 d]divn m5 c5 tussk.
It is speculated that the flu pandemic of 1890 may have been caused by this spillover event, and not by the influenza virus, because of the related timing, neurological symptoms, and unknown causative agent of the pandemic.
Cua jv diw 5 vn piluu e c5 fsw thi`x kv 1890 d]x n77xv jvn rarv fsaa vmv, k` /c5 ms a yinp5luvndha bayr`th, kv ku5c c`t` gu1th, nyuuthn5 r``l, kvn du]]r m5 ku1c kv min thi``x fsw.
Human coronavirus OC43 besides causing respiratory infections is also suspected of playing a role in neurological diseases.
Ksrsnabayr`th ran OC43 kvvl kv n77xdv kv luex l55k`, jvn b` ca diw 5 t22 kv tet k` gu11th r``l xith`.
In the 1950s, the human coronavirus OC43 began to diverge into its present genotypes.
Kv run 1950, vn ksrsnabayr`th ran OC43 cuv tok m5 d`kv piny w22 k` j55n6taap v t22 th5n v t`mv.
Phylogentically, mouse hepatitis virus (Murine coronavirus), which infects the mouse's liver and the central nervous system, is related to human coronavirus OC43 and bovine coronavirus.
Paylsjvtiksl5, bayr`th mieth ku]n (Muriin ksrsnabayr`th), min la luvvx cu`ny ku]n kvn r`l xith`dv, c``tv kvn ksrsnabayr`th ran OC43 kvn ksrsnabayr`th ciex man yaax.
Human coronavirus HKU1, like the aforementioned viruses, also has its origins in rodents.
Ksrsnabyr`th ran HKU1, cet kv bayr`thn5 tin ca lar n5 wen, tusskv k` r2l5 b`.
Coronaviruses vary significantly in risk factor.
Ksrsnabayr`thn5 gu1c kvn vl]x k` rik tin n77x kvn kv.
Some can kill more than 30% of those infected, such as MERS-CoV, and some are relatively harmless, such as the common cold.
Th11xkivn la n`k kvn 30% k` tin c5 kvn kv luvx, cet kv MERSCoV, k` th11xkivn kuiy rivkdivn cet kv thony-thony.
Coronaviruses can cause colds with major symptoms, such as fever, and a sore throat from swollen adenoids.
Ksrsnabayr`thn5 la kvn thony-thony v n77x kv nyuuthn5 t5 d5t, cet kv l2th pu11ny kiv kuuk l55k` k` tusrussx tin cv pu]t.
Coronaviruses can cause pneumonia (either direct viral pneumonia or secondary bacterial pneumonia) and bronchitis (either direct viral bronchitis or secondary bacterial bronchitis).
Ksrsnabayr`thn5 la n77x kvn pneumonia (d]x derv bayrsl pneumonia v civk kiv pneumonia bakt55rial in rvwdv) kv bsrskayth55th (d]x derv bayrsl bsrsxkayth55th v civk kiv bsrsxkayt55th bakt55rial in rvwdv).
The human coronavirus discovered in 2003, SARS-CoV, which causes severe acute respiratory syndrome (SARS), has a unique pathogenesis because it causes both upper and lower respiratory tract infections.Six species of human coronaviruses are known, with one species subdivided into two different strains, making seven strains of human coronaviruses altogether.
Vn ksrsnabayr`th ran 2 jekv kv 2003, SARS-CoV, min la n77x juey l55k` (SARS), tv pathsjvnvth5th d]divn kv f66 la luex l55k` a n77xv nhial k` n77xv jv piny. Kuay b1kvl k` ksrsnabayr`th ran x1c kv kv, kvl k`k kv ca jv d11k k` bun rvw k]kivn, m5 nyooth f66 ksrsnabayr`th ran v jic b1rsw.
Four of these coronaviruses continually circulate in the human population and produce the generally mild symptoms of the common cold in adults and children worldwide: -OC43, -HKU1, HCoV-229E, -NL63.
Xuaan k` lkv ksrsnabayr`thn5 titi j`l kv rvi nath ciax k` n77x kvn nyuuthn5 thony-thony` m5 tst k` naath tin d5t kvn gaat w55 mu]]n kvvliw: -OC43, -HKU1, HCoV-229E, -NL63.
Coronaviruses cause about 15% of commons colds.
Ksrsnabayr`thn5 n77x kv 15% thony-thonyn5.
The majority of colds are caused by rhinoviruses.
Thony-thonyn5 t5 xuan riwdivn n66xv rayn6bayr`th.
The four mild coronaviruses have a seasonal incidence occurring in the winter months in temperate climates.
Vn ksrsnabayr`thn5 xuaan tin kuiy rikdivkn la tusskv kv rvi p`thn5 jsam gu1thn5 tin ks1c-ks11c.
There is no preference towards a particular season in tropical climates.
Thilv m5 g77r tiit kv d``kn5 ruun` gu1thn5 tin l2th-l22th.
Four human coronaviruses produce symptoms that are generally mild:
Xuaan k` ksrsnabayr`thn5 ran la n77x kvn nyuuthn5 t5 tst.
The virus was officially named the SARS coronavirus (SARS-CoV).
Vn bayr`th cua csl v gsaa 5 SARS ksrsnabayr`th (SARS-CoV).
More than 8,000 people were infected, about ten percent of whom died.
Cuv naath t5 b``l 8000 luvx, k` cuv w`l pvrthvn n`k.
In September 2012, a new type of coronavirus was identified, initially called Novel Coronavirus 2012, and now officially named Middle East respiratory syndrome coronavirus (MERS-CoV).
Kv pay b1xuan 2012, cua ksrsnabayr`th m5 pay tussk jek, kv nhiam cua csl 5 ksrsnabayr`th m5 rvl rs 2012, k` vn t`mv ca ku csl v gsaa 5 ksrsnabayr`th d11r cu22c wec (MERS-CoV).
The World Health Organization issued a global alert soon after.
Cu mukt`p pusl` pu11ny wec mu]]n l``r th6p kv ksrv.
The WHO update on 28 September 2012 said the virus did not seem to pass easily from person to person.
Cu WHO l``r nysk kv th7p kv 28 pay b1xuan 2020 larv jv 5 bayr`th cetv kv m5 cv naath b5 mal dsp kv jivndv k` ram in d]x.
However, on 12 May 2013, a case of human-to-human transmission in France was confirmed by the French Ministry of Social Affairs and Health.
Kuv la f66 kv 12 pay xuaan 2013, cua jv nvn jivnv k` raan w22 k` ram in d]x k` Pvrvvny, nvvnv mukt`p kv ku5c ran kvn pual pu11ny.
In addition, cases of human-to-human transmission were reported by the Ministry of Health in Tunisia.
Nysk, dspdv k` radivn cua nvn cv tussk k` nyin xuan cua lar v mukt`p pusl` pu11ny k` Tunicia.
Two confirmed cases involved people who seemed to have caught the disease from their late father, who became ill after a visit to Qatar and Saudi Arabia.
Rvw k]kivn cua kv lar naath t5 cet m5 jek kvnv kv kivl k` gu1ndivn m5 pay luny jsk k` Katar kvn Thsdia Arab cua kv lar.
Despite this, it appears the virus had trouble spreading from human to human, as most individuals who are infected do not transmit the virus.
C`x v jvn 5ns, xotv vn bayr`th cetv kv m5 thilv jv lu1x kv jivndv k` raan we k` raan kv f66 th11x nath t5 cv k` /c5 kv naath dsp kv bayr`th.
The final name for the virus is Middle East respiratory syndrome coronavirus (MERS-CoV).
Ci6tdv min jsak vn bayr`th v ksrsnabayr`th d11r cu22c wec (MERS-CoV).
The only U.S. cases (both survived) were recorded in May 2014.In May 2015, an outbreak of MERS-CoV occurred in the Republic of Korea, when a man who had traveled to the Middle East, visited four hospitals in the Seoul area to treat his illness.
Kvl 2 c5 tussk k` U.S. (c5 jv kv t2k b`) cua jv gs1r piny kv 2014, Kv pay dhieec 2015,d`k fsaa MERS-CoV cuv tussk k` j5 Korea, m22 c5 wut m5 c5 we j1l k` d``r cu22c wec ben guel du2l5wal d1x xuaan kv g6r wal ju1thdv.
This caused one of the largest outbreaks of MERS-CoV outside the Middle East.
Vns cuv d` ju1th MERS-CoV jak` d55t raar wec M55d5lyith.
As of December 2019, 2,468 cases of MERS-CoV infection had been confirmed by laboratory tests, 851 of which were fatal, a mortality rate of approximately 34.5%.
Kv pay w`lrvw 2019, cua pek m5 2,468 t5 cv k`p kv MERS-CoV x`th kv th2m lab, 851 k` kv cu kv l5w, li11 m5 cet kv 34.5%.
In December 2019, a pneumonia outbreak was reported in Wuhan, China.
Kv pay w`lrvw 2019, cua d`k pneumonia lar 5 cv tussk rvi Wuhan, China.
On 31 December 2019, the outbreak was traced to a novel strain of coronavirus, which was given the interim name 2019-nCoV by the World Health Organization (WHO), later renamed SARS-CoV-2 by the International Committee on Taxonomy of Viruses.
Kv pay w`lrvw 31 2019, cua jv guic 5 vn d`kdv fsaa vmv n77xv ksrsnabayr`th in rvl rs, m22 cua moc ci6t kv nhiam 5 2019-nCoV v mukt`p pusla pu11ny wec mu]]n in d55t (WHO), kv ksrs cua jv nys kv ci6t 5 SARS-CoV-2 v ksmst55r wec mu]]n diaal kv min jsc k` bayr`th.
Some researchers have suggested the Huanan Seafood Wholesale Market may not be the original source of viral transmission to humans.As of 17 April 2020, there have been at least 153,822 confirmed deaths and more than 2,240,191 confirmed cases in the coronavirus pneumonia pandemic.
C5 th11x j5 g7r` x`c` jv kuan yi22r tin cam raan kv /c5 t] la kvn la tuk ju1th in dsp raam bayr`th th5n. Kv gu11th m5 cet kv 17 pay xuaan 2020, cuv te kv pek m5 253,822 t5 c5 l5w kv pek m5 b``l 2,240,191 t5 cv moc ksrsnabayr`th pneumonia in c5 fsw pac.
The Wuhan strain has been identified as a new strain of Betacoronavirus from group 2B with approximately 70% genetic similarity to the SARS-CoV.
Dux Wuhan cua jv nvn v la m5 paytussk k` ciex man betaksrsnabayr`th m5 be k` bu]n 2B cet kv pek m5 70% m5 c``t kv SARS-CoV.
The virus has a 96% similarity to a bat coronavirus, so it is widely suspected to originate from bats as well.
Vn bbayr`thv t22 kv c``th kv pek m5 96% kv ksrsnabayr`th xap, vns ca jv diw 5 tusskv kv xap b`.
The pandemic has resulted in travel restrictions and nationwide lockdowns in several countries.
Vn d`kdv fsaa cv cop k` f66 ca j`l xok kvn f66 ca wec g`k kvvliw rvi w55n5 diaal.
Coronaviruses have been recognized as causing pathological conditions in veterinary medicine since the 1930s.
Ksrsnabayr`th ca jv nvn n77xv ciaax pathsjvniksl rvi du22lwal leyn5 n5 kv run 1930.
Except for avian infectious bronchitis, the major related diseases have mainly an intestinal location.
Vn5 luex bsrsxkayt5th k`rsa, kvn ju1th diaal t5 xuan tin c``t la jekv kv rvi c55n.
Coronaviruses primarily infect the upper respiratory and gastrointestinal tract of mammals and birds.
Ksrsnabayr`thn5 kv nhiam kvn la luvvx kvn n5 nhial l55k` kvn ji1c leyn5 caak vn diit.
They also cause a range of diseases in farm animals and domesticated pets, some of which can be serious and are a threat to the farming industry.
L kvn ju1th t5 g66l a n77x b` k` ley tin yusp kv kvn ley du22l, th11xkivn la bvc kvn k` kv rivk k` yindutht5tr5 kak` leyn5.
In chickens, the infectious bronchitis virus (IBV), a coronavirus, targets not only the respiratory tract but also the urogenital tract.
K` ciex manp0l00k, Luex bayr`th bsrsxkayt55th (IBV), ksrsnabayr`th, /ca k``pv n5 l511k k`rsa la k``pv du]]p coown5 b`.
The virus can spread to different organs throughout the chicken.
Vn bayr`th bv cu]]x t5 xuan cu cop rvi pu11ny divvt.
Economically significant coronaviruses of farm animals include porcine coronavirus (transmissible gastroenteritis coronavirus, TGE) and bovine coronavirus, which both result in diarrhea in young animals.
V kuiy, ksrsnabayr`thn5 t5 xuan k` ley tin pivth kv te rvidivn k` psrthiin ksrsnabayr`th, (ksrsnabayr`th gathtvrstvrith in la dsap kv, TGE) kv ksrsnabayr`th ciex man mu]l, min la n77x c5th k` dvy leyn5.
Feline coronavirus: two forms, feline enteric coronavirus is a pathogen of minor clinical significance, but spontaneous mutation of this virus can result in feline infectious peritonitis (FIP), a disease associated with high mortality.
Ksrsnabayr`th ciax man nyaawn5: jic rvw, yintvrik ksrsnabayr`th nyaawn5 kuiy rivk in b` k` jv, duxdv f66 m5 cv cak nysk vn bayr`th vmv la luex per5tnit5th ksrsnabayr`th v n66xv (FIP), juey in d5t thi1k li`thdv.
Similarly, there are two types of coronavirus that infect ferrets: Ferret enteric coronavirus causes a gastrointestinal syndrome known as epizootic catarrhal enteritis (ECE), and a more lethal systemic version of the virus (like FIP in cats) known as ferret systemic coronavirus (FSC).
%ns b`, t22 kv bun ksrsnabayr`th d1x rvw t5 luvvx xaw: Yintvrik ksrsnabayr`th xaaw la n77xv nyuuthn5 rvi ji`c` m5 csal5 epidhuutik katvrhal Yintvrit5th (ECE),kvn bayr`th kvl m5 d]divn (cet FIP k` nyaawn5) m5 csal 5 ksrsnabayr`th c`p` xaaw (FSC).
There are two types of canine coronavirus (CCoV), one that causes mild gastrointestinal disease and one that has been found to cause respiratory disease.
Bun rvw k` ciex man ji66k kiv j5 k``pn5 (CCoV), kvl in n77x ju1th c55n t5 tst kvn kvl in ca ben jek n77x luex l55k`.
Mouse hepatitis virus (MHV) is a coronavirus that causes an epidemic murine illness with high mortality, especially among colonies of laboratory mice.
Bayr`th cu1ny ku]n (MHV) v ksrsnabayr`th m5 la d`k fsaa bv mur55n luvx kv li11 m5 d55t, v civk gu1thn5 tin te ku]]n lab th5n.
Sialodacryoadenitis virus (SDAV) is highly infectious coronavirus of laboratory rats, which can be transmitted between individuals by direct contact and indirectly by aerosol.
Bayr`th thialsdak5raysadvnti5th (SDAV) v ksrsnabayr`th m5 d5t luexdv vl]x k` ku]]n Lab, m5 la dsap kv kams kv gueer kvn jism.
Some strains of MHV cause a progressive demyelinating encephalitis in mice which has been used as a murine model for multiple sclerosis.
Th11x dussthn5 MHV n77x kvn demayelinvtix yinthvphlit5th k` ku]]n min ca lv ben k1n a la mur55n kv yithkvlsth5thn5 t5 xuan.
Significant research efforts have been focused on elucidating the viral pathogenesis of these animal coronaviruses, especially by virologists interested in veterinary and zoonotic diseases.
Dup g7r` x`c` t5 xuan c5 kvn diaal cooth kv g6r pathsjvnvthith bayrsl kv ku5c ksrsnabayr`thn5 leyn5 titi, v civk v bayrslsj5th tin cv lscdivn tusm k` ju1th leyn5.
Porcine coronavirus (transmissible gastroenteritis coronavirus of pigs, TGEV).
Psrthin ksrsnabayr`th (ksrsnabayr`th gathtvrsyintvrith5t kundhu]]r5 min la dsap kv kv TGEV).
Bovine coronavirus (BCV), responsible for severe profuse enteritis in of young calves.
Ksrsnabayr`th ciex man yaax (BCV), min la n77x dh6kdivn k` dvy tin ks11l.
Feline coronavirus (FCoV) causes mild enteritis in cats as well as severe Feline infectious peritonitis (other variants of the same virus).
Ksrsnabayr`th nyaawn5 (FCoV) la n77xv envtir5th m5 tst k` rvy nyaawn5 kvv luex pvr5tsnit5th m5 d55t b` (bu]n d]divn kv jvn bayr`th v kvls).
the two types of canine coronavirus (CCoV) (one causing enteritis, the other found in respiratory diseases).
Bu]n rvw k` ksrsnabayr`th ji66k (CCoV) (kvl la n77xv entvrit5th, min d]x jek vj rvi ju1th l55k`).
Turkey coronavirus (TCV) causes enteritis in turkeys.
Ksrsnabayr`th turk5 (TCV) la n77xv entvrit5th kv turk5n5.
Ferret enteric coronavirus causes epizootic catarrhal enteritis in ferrets.
Ksrsnabayr`th xaaw la n77xv epidhuutic katarhal entvrit5th kv xaawn5.
Ferret systemic coronavirus causes FIP-like systemic syndrome in ferrets.
Ksrsnabayr`th c`p` xaaw la n77xv nyuuth c`p` m5 cet kv nyuuth FIP k` xaaw.
Rabbit enteric coronavirus causes acute gastrointestinal disease and diarrhea in young European rabbits.
Ksrsnabayr`th p=lp==l la n77xv juey ji`c` m5 rup-rup kvn c5th kv dvy p=lp==l Yursp.
Porcine epidemic diarrhea virus (PED or PEDV), has emerged around the world.
Psrth5n ksrsnabayr`th (PED) kiv PEDV, cv tussk w55 mu]]n.
b'Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
b’Ksrsnabayr`th juey 2019 (COVID-19) v juey luex` m5 n66x kv v nyuuth ksrsnabar`th 2 l55k` m5 rup-rup (SARS-CoV-2).
Common symptoms include fever, cough, and shortness of breath.
Nyuuthn5 kv tin xuan kv leth pu11ny, kivl, kvl ci0k yieek`.
Other symptoms may include fatigue, muscle pain, diarrhea, sore throat, loss of smell, and abdominal pain.
Nyuuthn5 k]kivn dee kvn v cu]c, b0c r``l, c5th, kuuk l55k`, bath xu`c`, kvn b0c jivc.
The time from exposure to onset of symptoms is typically around five days but may range from two to fourteen days.
Gu11th in naxv kv jekdv kv tukdv pu]]ny vn nyuuthn5 kvv la malv n5n dhieec duxdv f66 la jv a tookv n5n rvw v we k` n5n w`lxuaan.
While the majority of cases result in mild symptoms, some progress to viral pneumonia and multi-organ failure.
C`x min la riw k` tin tussk v nyuuthn5 t5 tst, th11xkivn la r`th kv k` bayrsl pneumonia kvn p00n l1t cuxn5 pu11ny t5 xuan.
As of 17 April 2020, more than 2.24 million cases have been reported across 210 countries and territories, resulting in more than 153,000 deaths.
Kv 17 pay xuaan 2020, cua pek m5 b``l bathdssr5 t5 2.24 lar rvi w55n5 t5 210 kvn k2thn5, cu pek m5 153,000 l5`.
More than 568,000 people have recovered.The virus is primarily spread between people during close contact, often via small droplets produced by coughing, sneezing, or talking.
Naath t5 b``l 568000 cu kc x]]th. Vn bayr`th la copv ram in d]x kv gu11th in gueer naath rs jv, kv th11xdv we kv pusw-pussw kil` kvn thiam kiv ruac.
While these droplets are produced when breathing out, they usually fall to the ground or onto surfaces rather than being infectious over long distances.
C`x min kvn pusw-pussw titi la be kv raar min yi22 ran, la kvn a pvn piny kiv wu1thn5 kuakn5 v /c5 ms a 66 b5 kv r`th v b5 kv naath we luvx v n1n.
People may also become infected by touching a contaminated surface and then touching their eyes, nose, or mouth.
Naath ba d22 luex jek kv gueerivn kv wu`th kauakn5 tin c5 lu00x k` ba w`xkivn, wumkicvn kvn thukivn ben gueer kv kv.
The virus can survive on surfaces up to 72 hours.
Vn bayr`th la t2kv w55 k` du]]r in cv pvn th5n kv thaakn5 t5 75.
It is most contagious during the first three days after the onset of symptoms, although spread may be possible before symptoms appear and in later stages of the disease.The standard method of diagnosis is by real-time reverse transcription polymerase chain reaction (rRT-PCR) from a nasopharyngeal swab.
Jvn d5t rs1thdv kv naath kv n5n di]k ti n nhiam kv ksr k` min pay nyuuth kv tussk, c`x min derv naath dsp kv gu11th in xot nyuuthn5 kv /ken kv n5 jssc kvn gu11th in c5 jsak k` juey. The du]]p in thu]k in d22 gax jv v vn k0c psl5mvr`th (Rrt-ocr) kv bendv k` nathsp1r5nyjiaal yithwab.
The use of masks is recommended for those who suspect they have the virus and their caregivers.
L`th kuum` thus kvn wum gsaayv k` naath tin diiw f66 cv kv k`p kv bayr`th kvn naath tin yoop kv.
Recommendations for mask use by the general public vary, with some authorities recommending against their use, some recommending their use, and others requiring their use.
Min ca lar kv l`th kuum` tusk kvn rum gu1cv kv j5 lu`x` tin laar jv, l6k th11x j5 lu`x` l`thdv, th11xkivn v kvn 5 gsaa l`thdv, k` g77r th11xkivn l`thdv.
Currently, there is no vaccine or specific antiviral treatment for COVID-19.
T`mv thilv w`l kiv kvl m5 tusm kv bayral kv ku5c COVID-19.
Local transmission of the disease has been recorded in most countries across all six WHO regions.
Tin dsap kv juey ca kvn diaal gs1r piny rvi w55n5 t5 b1kvl diaal tin l`t WHO th5n.
Those infected with the virus may be asymptomatic or develop flu-like symptoms such as fever, cough, fatigue, and shortness of breath.
Naath tin ca k`p v bayr`th dee kvn thil nyuuthn5 kiv dee kvn te kv nyuuthn5 t5 cet kv nyuuthn5 p5luu cet leth pu11ny, kivl, b0c pu11ny, kvn ci0k yieek`.
Emergency symptoms include difficulty breathing, persistent chest pain or pressure, confusion, difficulty waking, and bluish face or lips; immediate medical attention is advised if these symptoms are present.
Nyuuthn5 tin ru]p-ru]]p kv kvn bvc civvx` yieek`, b0c kath kv gu11th m5 b``r kiv thiakdv, nyussn wec, b0c k2r` n5n kv nhiam m5 cv t]c kiv thok; gsaa f66 dee ran we dueelwal m5 cv kvn nyuuthn5 titi nvn.
Less commonly, upper respiratory symptoms such as sneezing, runny nose or sore throat may be seen.
Vdak, nyuuthn5 nhial l55k` cet kv thiam, lussr wu]m kv p5w kiv li``k.
Gastrointestinal symptoms such as nausea, vomiting and diarrhoea have been observed in varying percentages.
Nyuuthn5 livc cet kv jaal lsaac, x6k kvn c5th c5 kv tussk b` rvi pekn5 t5 g66l.
Some cases in China initially presented only with chest tightness and palpitations.
Th11x nath k` China cu kv ben kv root lsaac k`rsa kvn ku2t lsaac m5 gu00l.
In some, the disease may progress to pneumonia, multi-organ failure, and death.
K` th11xkivn, cuv r`th pneumonia vn juey, p00n l1t cu]]x5 puq11ny t5 xuan, kvn li11.
This is called the incubation period.
Vn nmv cua jv csl 5 gu11th in ttokv rs kv jv.
The incubation period for COVID-19 is typically five to six days but may range from two to 14 days.
Gu11th tuk`dv vn COVID-19 la malv a n5n dgieec v we k` b1kvl duxdv f66 derv tussk kam n5n5 d1x rvw v we k` n5n 14.
97.5% of people who develop symptoms will do so within 11.5 days of infection.Reports indicate that not all who are infected develop symptoms.
Pek m5 97.5% k` naath tin tussk nyuuthn5 la jvn v n5n t5 11.5 kv gu11th luex`. C5 l``rv lar 5/c5 kv kvn naath diaal tin cv k`p la te kv nyuuthn5 t].
The role of these asymptomatic carriers in transmission is not yet fully known; however, preliminary evidence suggests that they may contribute to the spread of the disease.
Min l`t kvnv kvn nyuuthn5 titi kv gu11th d6p ju1th ku1c kv jv; kuv la f66 nyooth m5 dux tti jv vn f66 kvn lu`k kvn juey kv f66 bv d``k rvi fsaa.
The proportion of infected people who do not display symptoms is currently unknown and being studied, with the Korea Centers for Disease Control and Prevention (KCDC) reporting that 20% of all confirmed cases remained asymptomatic during their hospital stay.
Pek in a thil nyuuthn5 titi rvi nath /ca jv x`c kvvliw t`mv, k` kua jv lv g7r, ca jv lar mukt`p g1x ju1th k` Koreaa (KDC) lar kv jv 5 20% k` pek in ca x`th 5 cvmoc juey te kv v la t5 thil nyuuthn5.
China's National Health Commission began including asymptomatic cases in its daily cases on 1 April; of the 166 infections on that day, 130 (78%) were asymptomatic at the time of testing.
Ksm55cin mukt`p` pusl` pu11ny k` China cv to kv m5 mat pek in thil nyuuthn5 rvi kuen`dv n5 kv 1 pay xuaan; k` rvi nvv5 t5 166 t5 cv moc juey kv jvn c`x vms 130 (78%) thil kv nyuuthn5 kv gu11th 2 th0m kv kv.
Both sputum and saliva can carry large viral loads.
Vn thuny kvvl kvn ruvy la te rvidivn kv bayr`th m5 d55t.
Loud talking releases more droplets than normal talking.
Ruac kc jsw m5 d55t la pusw=pussw ruvvn5 t5 xuan v jak` kac k` ruac v m``th.
A study in Singapore found that an uncovered cough can lead to droplets travelling up to 4.5 meters (15 feet).
G6r x`c` m5 ca l1t kc Thixgap77r nyoothv jv kivl m5 /k1n kum we pusw-pussw kv n5 k` th22mn5 t5 4.5 k11th ci6k` d1x (15).
Though the virus is not generally airborne, the National Academy of Science has suggested that bioaerosol transmission may be possible and air collectors positioned in the hallway outside of people's rooms yielded samples positive for viral RNA.
C`x n5 vn bayr`thvmv /cv rs dieth rvi jsams, c5 duelg]r` thaay 5 d6pdv kv rvi jsam b` t22 th5n v cu th``kn5 jsam t5 ca ku2x raar du22l jv ben nyoth 5 te kvn kv RNA bayrsl.
Some medical procedures such as intubation and cardiopulmonary resuscitation (CPR) may cause respiratory secretions to be aerosolised and thus result in airborne spread.
Th11x l`tn5 du22lwal cet kv cot dupiiw` pu]]ny ran kv tuanyn5 lsaac raam m5 c5 musn (CPR)la kvn li11k v jak` te kv l`k, derv li11k n6x f66 bv juey jak` dieeth rs rvi jsam.
While there are concerns it may spread via feces, this risk is believed to be low.The virus is most contagious when people are symptomatic; while spread may be possible before symptoms emerge, the risk is low.
C`x min cv lv tv divvw 5 d22 jv jek rvi civth, rivk vmv derv ku ku00. Vn bayr`th la r]thv kv d6p nath vl]x m5 tenaath tin cv k`p kv nyuuthn5; c`x min derv naath dsp b` min /ken nyuuthn5 n5 jssc, xotv kuiy rivkdv.
The European Centre for Disease Prevention and Control (ECDC) says while it is not entirely clear how easily the disease spreads, one person generally infects two to three others.The virus survives for hours to days on surfaces.
K` mukt`p g1x ju1th kvn pendv ben k` Yursp, (CDC) ca jv lar 5, c`x ms /kenv jssvs v gsaa vn du]]p in thi`x juey v piny, ram kvl m5 cv k`p la dspv nvy rvw k]kivn kiv di]k. Vn bayr`th la tekv wu]th5 kuakn5 tin cv nyuur th5n kv thaakn5 kv n5n.
Specifically, the virus was found to be detectable for one day on cardboard, for up to three days on plastic (polypropylene) and stainless steel (AISI 304), and for up to four hours on 99% copper.
V civk vn bayr`th cua jv nvn l5pv w55 thanduk` kv c`x kvl, kv n5n di]k w55 p5l11thik` (psl5psrspaylvnv) kvl yi22th r2t (AISI 304), kv thaakn5 xuaan w55 99% l`x`.
This, however, varies depending on the humidity and temperature.
Vns kuv lv te kv d``k kv ks1c wecs kvn l2thdv.
Soap and detergent are also effective if correctly used; soap products degrade the virus' fatty protective layer, deactivating it, as well as freeing them from skin and other surfaces.
Thaabuuny kvn d5tvrjvn gsw kv b` m5 ca kv nax kv gu11thdivn a gsaa; thaabuuny jvn la kuum jsak bayr`th` min thisl v lvvnyv, bv jak` thil l1t k` bv jak` /cv r7m kvn pu1ny kuakn5 tin k]x.
Other solutions, such as benzalkonium chloride and chlorhexidine gluconate (a surgical disinfectant), are less effective.In a Hong Kong study, saliva samples were taken a median of two days after the start of hospitalization.
Dup tin k]x cet kv bvndhalksni66m kslsraad kvn kslsrhekthidaad g5luksnvvd (g``x luex` gu11th r2t`), thil kv lu1x m5 d55t. K` x`c m5 ca l1t k` Hong Kong, cua ruvy k1n kv n5n rvw tin nhiam v xot gu11th tum`.
In five of six patients, the first sample showed the highest viral load, and the sixth patient showed the highest viral load on the second day tested.
K` ju1th d1x dhieec v we k` b1kvl, th2m in nhiam cuv bayr`th mi d55t nyoth, k` cu gu1n ju1th in b1kvnivn te kv bayr`th m5 d55t kv th2m in rvwdv.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel severe acute respiratory syndrome coronavirus, first isolated from three people with pneumonia connected to the cluster of acute respiratory illness cases in Wuhan.
Nyuuth ksrsnabayr`th 2 in d55t (SARSCoV-2) v nyuuth ksrsnabayr`th l55k`, m22 n0n kv kv nhiam k` naath di]k t5 te kv pneumonia m5 cv mat kv juey in l55k` min d55t k` Wuhan.
All features of the novel SARS-CoV-2 virus occur in related coronaviruses in nature.
Civx ksrsnabayr`th SARSCoV-2 in rvl rs diaal tussk kvn k` bayr`thn5 diaal tin c``t n5 c`k`divn.
Outside the human body, the virus is killed by household soap, which bursts its protective bubble.SARS-CoV-2 is closely related to the original SARS-CoV.
Raar pu11ny ran, vn bayr`th la thaabuuyn jv a n`k, min dhi`y kuumn5 kv. SARS-CoV-2 c``tv a thi1k vl]x kvn SARS-CoV.
The lungs are the organs most affected by COVID-19 because the virus accesses host cells via the enzyme angiotensin-converting enzyme 2 (ACE2), which is most abundant in the type II alveolar cells of the lungs.
Kvn pu]th kv kvn cu]]x in la luvvx COVID-19 jv vl]x kv f66 bayr`th la cop thvl5 l== in cv k`p kv endhaamaxgi6tvnthin in r55t endhaam 2 (ACE2), min c5 mat k` bu]n II k` albislsr thvl5 pu]]th.
The virus uses a special surface glycoprotein called a "spike" (peplomer) to connect to ACE2 and enter the host cell.
Vn bayr`th bv w5c m5 rvl rs m5 csal5 g5layk6protein in csal kv “yithpaak” (pep5lsmvr) jak` gu11thdv kv f66 bv we rs tusm k` ACE2 k` bv cu we rvc th0l5 l== in cv hap.