simply zap there's circulating tumor cells using a higher energy laser pulse that would be a Wang approach there are certain other pharmaceutical approaches you can think of I talked about histology right so how can we make standard histology now invasive in vivo and we can actually detect the cell nuclei directly by using photo cosa microscopy we get an image that looks almost like standard HD staining histology so this is the standard histology this is the same piece of tissue that we acquired using our native