this type of resolution in fact this is a form of reporter gene imaging or a form of molecular imaging again three colleagues receive the Nobel Prize in 2008 for their discovery of force and proteins you might have heard of you know this is a huge discovery that allows us to follow gene expressions but it's all fluorescence based by using standard optical imaging you cannot penetrate these so all of the applications are limited to cells or animals at a very shallow depth now we're talking about multiple centimeters