yeah so the final question is about these new anticoagulants and are they easier to regulate in the coumadin and they are definitely easier to regulate they were all tested all four of them in huge huge trials where one half took coumadin and had all the regulation issues and the other half took these new medicines with no regulation okay so you weren't upping and adjusting the dose like you have to do with coumadin and all four of these you know were either as good or better than coumadin in these big trials so they were as good or