formulate with deep learning then one of the things I am actually very excited about is that I can do end-to-end optimization so if I know what clinical measurements I want to make I can optimize the acquisition the reconstruction and the analysis for exactly that purpose and I think that's a very powerful paradigm especially because these scanners are effectively programmable there are piece of programmable hardware and you can optimize what they do and of course you can couple it with what Big Data and an multimodal data so I just want to finish