out these are all very very recent and it turns out that fungi produced the P chimeric acid related to the chloral chlorinated coumarins that Scott Franklin our fund their active against tuberculosis by the way and it turns out that the absence of P chimeric acid stops the up regulation of the cytochrome p450 pathway bees only have 47 cpy genes whereas most insects have 80 and the absence of P chimeric acid coming from fungi turns off their mono oxygenase pathway and so they can't detoxify this accumulation of all these