but here's the catch so when your body is septic it affects your kidneys it deteriorates your kidneys ability to filter out creatinine so creatinine level rises but there are many other things that can affect your kidneys ability to filter out creatinine for example if you have chronic kidney disease you're very likely to have high creatinine levels so now what truth has to do is to figure out is your creatinine high because of sepsis or because of chronic kidney disease or the numerous other factors that need to high