been studies that show that TPA actually works out to about four and a half or five hours and in Europe the equivalent of the FDA has approved it to four and a half hours so it's Stanford and many other stroke centers even though our FDA says three hours we'll go out to about four and a half five hours with TPA but we're doing this against the advice of the FDA because they say give it very very early but that means that only about 5% of stroke patients are going to get it because they don't come in soon enough we've done a study here at