  the purkinje fibers ( ) (purkyne tissue or subendocardial branches) are located in the inner ventricular walls of the heart, just beneath the endocardium in a space called the subendocardium. these fibers consist of specialized cardiomyocytes that are able to conduct cardiac action potentials more quickly and efficiently than any other cells in the heart. purkinje fibers allow the heart's conduction system to create synchronized contractions of its ventricles, and are, therefore, essential for maintaining a consistent heart rhythm. ==histology== purkinje fibers are a unique cardiac end-organ. further histologic examination reveals that these fibers are split in atria and ventricles walls. the electrical origin of atrial purkinje fibers arrives from the sinoatrial node. given no aberrant channels, the atrial and ventricular purkinje fibers are distinctly shielded from each other by collagen or the cardiac skeleton. the purkinje fibers are further specialized to rapidly conduct impulses (numerous fast voltage-gated sodium channels and mitochondria, fewer myofibrils than the surrounding muscle tissue). purkinje fibers take up stain differently from the surrounding muscle cells because of relatively fewer myofibrils than other cardiac cells and the presence of glycogen around the nucleus causes purkinje fibers to appear, on a slide, lighter and larger than their neighbors, arranged along the longitudinal direction (parallel to the cardiac vector) . they are often binucleated cells. ==function== heart rate is governed by many influences from the autonomic nervous system. the purkinje fibers do not have any known role in setting heart rate but are influenced by electrical discharge from the sinoatrial node. during the ventricular contraction portion of the cardiac cycle, the purkinje fibers carry the contraction impulse from both the left and right bundle branch to the myocardium of the ventricles. this causes the muscle tissue of the ventricles to contract and generate force to eject blood out of the heart, either to the pulmonary circulation from the right ventricle or to the systemic circulation from the left ventricle. purkinje fibers also have the ability of firing at a rate of 15-40 beats per minute if ups
Cardiac_anatomy Cardiac_electrophysiology