  neuropeptide y (npy) is a 36-amino acid neuropeptide that acts as a neurotransmitter in the brain and in the autonomic nervous system of humans; slight variations of the peptide are found in many other animals. in the autonomic system it is produced mainly by neurons of the sympathetic nervous system and serves as a strong vasoconstrictor and also causes growth of fat tissue. in the brain, it is produced in various locations including the hypothalamus, and is thought to have several functions, including: increasing food intake and storage of energy as fat, reducing anxiety and stress, reducing pain perception, affecting the circadian rhythm, reducing voluntary alcohol intake, lowering blood pressure, and controlling epileptic seizures. ==discovery== following the isolation of neuropeptide-y (npy) from the porcine hypothalamus in 1982, researchers began to speculate about the involvement of npy in hypothalamic-mediated functions. in a 1983 study, npy-ergic axon terminals were located in the paraventricular nucleus (pvn) of the hypothalamus, and the highest levels of npy immunoreactivity was found within the pvn of the hypothalamus. six years later, in 1989, morris et al. homed in on the location of npyergic nuclei in the brain. furthermore, [[i
Human_proteins Neuropeptides