 commerce is a mississippi river city in scott county, missouri, united states. the population was 67 at the 2010 census. ==history== in 1788, the present site of commerce was first occupied by french settlers, making commerce apparently the third-oldest present site settlement in missouri after st louis, missouri and st. charles, missouri. a trading post established in 1803 served as the center of commerce for the region, hence the name of the settlement.{{cite book | url=http://books
Cities_in_Scott_County,_Missouri Missouri_populated_places_on_the_Mississippi_River