     gamma-glutamyl transferase or gamma-glutamyl transpeptidase (also Î³-glutamyl transferase, ggt, ggtp, gamma-gt) () is an enzyme that transfers gamma-glutamyl functional groups. it is found in many tissues, the most notable one being the liver, and has significance in medicine as a diagnostic marker. ggt catalyzes the transfer of the gamma-glutamyl moiety of glutathione to an acceptor that may be an amino acid, a peptide or water (forming glutamate). ggt plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis and degradation of glutathione and drug and xenobiotic detoxification. other lines of evidence indicate that ggt can also exert a prooxidant role, with regulatory effects at various levels in cellular signal transduction and cellular pathophysiology. == function == ggt is present in the cell membranes of many tissues, including the kidneys, bile duct, pancreas, gallbladder, spleen, heart, brain, and seminal vesicles. it is involved in the transfer of amino acids across the cellular membrane and leukotriene metabolism. it is also involved in glutathione metabolism by trans
Chemical_pathology EC_2.3.2 Genes_on_chromosome_22