 in medicine (hematology), bleeding diathesis (or bleeding tendency or predisposition or h(a)emorrhagic diathesis) is an unusual susceptibility to bleeding (hemorrhage) mostly due to hypocoagulability, in turn caused by a coagulopathy (a defect in the system of coagulation). several types are distinguished, ranging from mild to lethal. also, bleeding diathesis can be caused by thinning of the skin or impaired wound healing. ==hypocoagulability== hypocoagulability is a bleeding diathesis caused by coagulopathy. ===causes=== while there are several possible causes, they generally result in excessive bleeding and a lack of clotting. ====acquired==== acquired causes of coagulopathy include anticoagulation with warfarin, liver failure, vitamin k deficiency and disseminated intravascular coagulation. additionally, the haemotoxic venom from certain species of snakes can cause this condition, for example bothrops, rattlesnakes and other species of viper. viral hemorrhagic fevers include dengue hemorrhagic fever and dengue shock syndrome leukemia may also cause coagulopathy. ====autoimmune causes of acquired coagulation disorders==== there are autoimmune causes of coagulation disorders. they include acquired antibodies to coagulation factors, termed inhibitors of coagulation. the main inhibitor is directed against clotting factor viii. another example is antiphospholipid syndrome an autoimmune, hypercoagulable state. ====genetic==== some people lack genes that typically produce the protein coagulation factors that allow normal clotting. various types of hemophilia and von willebrand disease are the major genetic disorders associated with coagulopathy. rare examples are bernard-soulier syndrome, wiskott-aldrich syndrome and glanzmann's thrombasthenia. generally, if one parent has a type of bleeding diathesis, there is a 95% chance of passing it onto their offspring, since most genetically acquired coagulopathies are sex-linked, x chromosome disorders. ===symptoms=== {|class="wikitable" ! symptom !! disorders |- |petechiae (red spots) | *wiskott-aldrich syndrome, where they may resemble a few bruiseswiskott-aldrich syndrome the international patient organisation for primary immunodeficiencies (ipopi). *acute leukemia disorders of thrombosis and hemostasis: clinical and laboratory practice. page  rodger l. bick. edition 3, illustrated. isbn 0-397-51690-8, isbn 9
Coagulopathies