Use of the mobile application was greater than in a previous trial and was associated with greater sun protection , especially among women .


Between-group effect sizes were 0.78 ( P < .001 ) in PE and 0.65 ( P = .001 ) in EMDR .


Future investigations on the efficacy and safety in larger samples over a longer follow-up period are needed before establishing management strategies for SB with BoNT-A .


GLP-1 and BNP were infused in incremental doses via brachial artery .


Women compared with men had higher ischemic stroke rates ( aspirin , 3.99 % versus 2.28 % ; apixaban , 1.55 % versus 0.82 % ) but similar bleeding rates ( aspirin , 1.29 % versus 1.22 % ; apixaban , 1.15 % versus 1.36 % ) .


A higher AZA dose at enrollment was an independent predictor for relapse ( p < 0.05 ) .


We examined whether chronic physical health problems moderated changes in depression and substance use among dual diagnosed individuals during and in the year following treatment .


A rigorously designed and executed sexual assault resistance program was successful in decreasing the occurrence of rape , attempted rape , and other forms of victimization among first-year university women .


YAM was effective in reducing the number of suicide attempts and severe suicidal ideation in school-based adolescents .


CID estimates ranged from 0.5 to 1.2 for the MENQOL domains and total score .


Non-randomized ( NR ) subjects ( never met stability criteria ) received monthly injections .


Thirty-four AEs were returned .


The degree of sedation was greater in X-IM only at 15 min when compared with X-Yintang group .


A total of 26 Department of Radiology physicians were randomized in a single-blind trial to either the SMART program or a wait-list control arm for 12 weeks .


Subjects in the LQG group received a LQG program consisting of four 45-minute sessions each week and daily walking for 30 minutes for 6 months .


The MILK diet had no significant effect on LDL-C , triglycerides , LDL size , CRP and cell adhesion molecule concentrations and on indicators of insulin sensitivity .


Nurse-derived office BP ( mean of 5 measurements according to guidelines ) and 24-h ambulatory BP were determined for 592 participants from 198 families ( 67 spouse pairs , 361 parent-child pairs , and 169 sibling-sibling pairs ) , with 12 families having three generations , from an urban developing community of black Africans .


Those using the tailored intervention received tailored content based on models of health behavior via the website and mobile fully automated text messages .


The study also uses EEG to confirm that improved driving performance is concurrent with improved driver alertness .


Non-inferiority was by seroconversion difference ( TTSCC-TTCTC ) < 5 % and ratio of GMCs ( TTSCC/TTCTC ) < 1.5 .


International Standard Randomised Controlled Trial Number Register : ISRCTN58396079 .


Twelve months of treatment with 500IR and 300IR sublingual tablets of HDM allergen extracts was efficacious and well tolerated .


This issue may play a role in the optimization of operating room management and raise interest about the usefulness of acupuncture on unconsciousness states of different nature .


Organizations delivering restorative home care services that include an exercise component should consider whether LiFE rather than the exercise program they are currently using could help their clients achieve better outcomes .


Little research has examined whether a two-sample FIT affects participant uptake , compared with a one-sample FIT .


Relatively little is known about the requirement of analgesia for this procedure .


Of note , mMRC scale scores were similar ( 1 point ) in 46 % of patients , worse in 36 % , and better in 18 % at 1 year .


Fifty-eight patients were randomly assigned to either the control group ( CG ) or the aerobic training group ( TG ) .


In the SSTS group , more patients and nurses responded `` good '' or `` excellent '' on the global assessments compared with placebo ( P < 0.001 ) .


There has not been sufficient data to evaluate the serial vascular healing pattern after everolimus-eluting stent ( EES ) implantation .


Medical nurses certified at the N to N2 level in a municipal hospital in Taipei City were enrolled as participants ( N = 78 ) and divided into an experimental group and control group using stratified purposive randomization .


At the end of 6 and 12 months , the ZOE and MPRCF success rates were 100 % both in clinical and radiographic evaluation .


The risks and benefits of initiating antiretroviral treatment ( ART ) at high CD4 cell counts have not been reliably quantified .


Three hundred and sixty university students randomly received an unlabelled vignette depicting one of six mental disorders to be evaluated on the four variables on a Likert-type scale .


Twenty-seven dentistry clinics in two Swedish counties were randomized to provide either a structured brief advice based on the 5 A 's model or usual care .


The QD and BID groups did not significantly differ in the following : percentages of patients with 25 % ( 63.41 % and 67.82 % , respectively ; P = .349 ) or 4-point improvement in total IPSS ( 65.85 % and 69.31 % , respectively ; P = .457 ) , maximum urinary flow rate improvement 30 % ( 47.32 % and 40.59 % , respectively ; P = .172 ) , changes in IPSS voiding subscore ( -4.42 4.93 and -4.65 4.77 ; P = .641 ) , IPSS storage subscore ( -2.05 3.07 and -2.52 2.97 ; P = .117 ) , quality of life ( -1.19 1.49 and -1.40 1.42 ; P = .136 ) , maximum urinary flow rate ( 3.55 5.93 and 3.74 6.79 mL/s ; P = .768 ) , International Continence Society male questionnaire score , Patient Goal Achievement Score , or Treatment Satisfaction Question .


High levels of IL-8 in STEMI patients complicated with HF were associated with less improvement in left ventricular function during the first 6 weeks after PCI , suggesting a possible role of IL-8 in the reperfusion-related injury of post-ischemic myocardium .


To observe the clinical effect and safety of Sulfasalazine ( SASP ) combined with ZHUANG medicine mediated thread moxibustion ( ZMMTM ) for patients with mild and moderate ulcerative colitis ( UC ) .


In the 905 patients who died postenrolment in the PLATO trial ( n = 18624 ) , reviewers , blinded to study treatment , subclassified direct causes of death and evaluated whether infection or bleeding events contributed to fatal events .


Midwives have a key role in preparing mothers to parent twins .


Furthermore , the possibility of delivering mental health care through the internet has not yet been explored in this population .


Prophylactic use of nonsteroidal anti-inflammatory drugs did not have an ergogenic effect on running performance after exercise-induced muscle damage in male long-distance runners .


Regarding feasibility , HD-tDCS treatment studies can be implemented when designed similarly to documented CS-tDCS studies .


Patients were required to continue maintenance treatment with stable medium-dose ICS for at least 4weeks prior to and during the treatment period .


We conducted a randomized controlled clinical trial comparing DFI and OS of 147 women with stage IIIB squamous cervical cancer who received either cisplatin plus RT ( CRT ) or RT alone ( 72 patients in the CRT group and 75 patients in the RT-only group ) .


Thirty-nine patients were allocated to the NE group , and 36 were allocated to the AS group .


To assess the efficacy of oral transmucosal meloxicam for pain relief in lambs at marking .


The trial was registered , ISRCTN38375681 .


In the case of screening positive in any of these tests , the women were followed up until a full diagnosis could be obtained .


A randomized controlled trial of ART versus an Attention Control ( AC ) regimen was conducted among 57 U.S. service members/veterans .


No significant changes were found between high - and low-output groups regarding seizure frequency .


Study results bring attention to disease management programs such as peer support networks that empower the patients that shift some of the responsibility to them .


Outcomes included hemoglobin A1c ( HbA1c ) levels , fasting blood glucose , lipid profiles , anthropometrics , and blood pressure .


Elevated sCD40L levels independently predict recurrent stroke in patients with minor stroke and transient ischemic attack .


At the end of the period of treatment with cinacalcet , for both variants of hyperparathyroidism , a statistically significant reduction in the overall number and in the diameter of renal stones was found .


Large follicles giving rise to good-quality embryos had significantly higher estradiol and progesterone levels and estradiol to T , estradiol to androstenedione , and progesterone to estradiol ratios , compared with small follicles , leading to poor-quality embryos .


In cross-sectional analysis , we found a moderating effect of adherence with alliance on treatment outcome , indicating that the better the therapeutic alliance , the stronger the effect of adherence on treatment outcome .


This study addresses the extent to which DSM-IV and DSM-5 definitions of acute stress disorder ( ASD ) predict subsequent posttraumatic stress disorder ( PTSD ) and related psychiatric disorders following trauma .


This prospective comparative study was done to evaluate the effectiveness of implants of different design ( titanium elastic intramedullary nail versus anatomical precontoured dynamic compression plate ) in treatment of displaced midshaft clavicular fractures .


When the simulated patient sustained ventricular fibrillation , the time required to report this arrhythmia was recorded .


The patients in one group had a HAL instillation before surgery , and they first had a white-light and after that a blue-light cystoscopy ( BL group ) and resection .


Weekly outcome measures included Clinical Global Impression Scale ( CGI ) , self-reported cocaine use , urine toxicology and the Hamilton Depression Scale ( Ham-D ) .


Ranibizumab treatment guided by disease activity was noninferior to VA stabilization-guided retreatment based on mean average BCVA change from baseline to month 1 through month 6 ( group II : +11.7 vs. group I : +11.9 ETDRS letters ; P < 0.00001 ) .


Serum phosphorus concentrations were maintained during the extension study .


Although limitation of pronation/supination following both-bone forearm fractures in children is often attributed to an angular malunion , no clinical study has compared pronation/supination and angular malalignment of the same child by analysis of prospectively collected clinical data .


In Study 2 , assessing the effect of N2 O itself , 23 volunteers consumed water saturated with N2 O or with CO2 10 min after a mini-drink ( 180 kcal ) .


Our objective was to demonstrate the superiority of pasireotide LAR over octreotide LAR in medically naive patients with acromegaly .


The duration of the masseter muscle rehypertrophy was significantly prolonged in Group 1 patients .


The usual care group received palliative care only if requested by the admitting physician .


While dry mouth was the most common adverse event ( group A : 28.4 % vs. B : 30.4 % , p = 0.783 ) , the severity of dry mouth was significantly less in the group A than B ( p = 0.042 ) There were no significant differences in other safety profiles .


In control group , placebo was given .


Thrombolysis in myocardial infarction ( TIMI ) flow , creatine kinase MB isoenzyme ( CK-MB ) levels , acute thrombus events , efficacy and safety endpoints at Day 7 , Day 30 , 6 months and 1 year ( efficacy endpoints : death , myocardial infarction , target vessel revascularization and ischemic stroke ; safety endpoints : bleeding and thrombocytopenia ) were observed and compared between the two groups .


One hundred thirty-five subjects were stratified by chronic pelvic pain or no chronic pelvic pain .


Intention-to-treat analyses revealed PFWD improved within group A ( 160 m to 204 m , p = .03 ) , but not group B ( 181 m to 188 m , p = .82 ) .


The primary outcome was child BMI percentile at 2-year follow up .


We evaluated 105 patients with nonalcoholic fatty liver disease ( NAFLD ) , 121 patients with biopsy-proven hepatitis C ( 61 patients with fatty liver and 60 patients without fatty liver ) , 50 patients with inflammatory bowel disease ( IBD ) , and 109 patients with dyspepsia .


Cost-effectiveness analysis , using cost and quality-of-life data gathered in a trial of SE for veterans with SCI .


The success rate was higher in the BMG than in the PSF group ( 89.5 % vs 83.3 % ) , but not statistically significant different .


When first approved in the European Union ( EU ) , the omalizumab dosing table had upper bodyweight and IgE limits of 150kg and 700IU/mL , respectively .


Secondary outcomes included number of needle redirections , procedure-related pain , patient satisfaction with the block , success rate , sensory and motor onset times , block duration , and complication rates .


Twenty-nine PFS events were assessed by independent review ( 16 with trabectedin ; 13 with DXCT ) .


This three arm pragmatic randomized trial will involve the recruitment of 261 patients from primary care clinics in metropolitan and regional areas of New South Wales , Australia .


The scores of NPQ and MPQ the acupuncture-moxibustion group were lower than that of the other two groups .


Presently , needle-knife sphincterotomy ( NKS ) is a commonly used precut technique .


Secondary endpoints were pain scores [ numeric rating scale ( NRS ) ] at rest and with coughing , severity of nausea and state of sedation .


The primary end point was time to first SRE , defined as radiation to bone , clinical fracture , spinal cord compression , surgery to bone , or death as a result of prostate cancer .


All patients showed fever and other symptoms , including rhinorrhea ( n = 38 ) , cough ( n = 50 ) , sore throat ( n = 39 ) , arthralgia or myalgia ( n = 46 ) , and general malaise ( n = 50 ) .


Analyses of covariance were conducted to examine changes in physical function between the two conditions at the end of the intervention to 6-month follow-up .


Thirty-day urgent TVR ( 1.1 % vs. 0.9 % , p = 1.0 ) , myocardial infarction ( 4.0 % vs. 6.4 % , p = 0.3 ) , and angiographic complication ( 11.2 % and 10.8 % , p = 0.9 ) rates were similar with pegnivacogin and heparin .


Lixisenatide provided a significant reduction in HbA1c at Week 24 versus placebo ( LS mean : -0.85 % vs. -0.10 % ; p < 0.0001 ) and more patients achieved HbA1c < 7.0 % ( 36.4 % vs. 13.5 % ; p < 0.0001 ) .


This was a randomized crossover pilot study in 19 preterm infants with gestational age between 28 and 34 weeks .


There was no significant difference among the three hypnosis conditions .


This will be done in all hospitals at baseline and after completion of the intervention period .


At baseline , both groups did not differ in neuropsychological test performance , clinical impairment , or functional disability .


Urology Department .


To investigate the impact and mechanisms of vitamin D deficiency ( VDD ) on the outcome of elderly patients with diffuse large B-cell lymphoma ( DLBCL ) .


Self-reported flossing was assessed longitudinally at 2 and 6 months .


In patients with baseline HbA1c 53mmol/mol ( 7.0 % ) , 32.4 % of patients in the linagliptin group and 13.8 % in the placebo group achieved HbA1c < 53mmol/mol ( 7.0 % ) ( odds ratio2 .94 ; P = 0.0033 ) .


Hazard ratios for mortality were 3.95 ( 95 % confidence interval , 1.46-10 .65 ) for high versus low and 1.92 ( 95 % confidence interval , 0.65-5 .65 ) for medium versus low dose ; however , multiple analyses raised uncertainty about the survival/dose relationship .


Approximately 1 in 5 pregnant women in the United Kingdom are obese .


There were no intergroup differences for catecholamines plasma levels ( adrenaline P = 0.123 ; noradrenaline P = 0.281 ; dopamine P = 0.173 ) , but there were for serotonin levels ( P = 0.045 ; F ( 1,38 ) = 4.296 ; R ( 2 ) = 0.10 ) .


Moreover , the study establishes the feasibility of using CSF biomarkers in proof-of-concept trials , allowing a low number of participants and short study duration .


The data suggests that once-daily IV ( or IV/PO ) moxifloxacin has a comparable efficacy and safety profile to antibiotic regimens approved previously in the subgroup of patients with secondary peritonitis of mild-to-moderate severity .


There was no significant difference between the mechanical method group and the pharmacological method group in CSR and change in Bishop Score .


To test the hypothesis that early fat supplement and FO increases post-resection protein absorption , intestinal RNA , protein without decreasing intestinal arachidonic acid ( AA ) in premature infants with an enterostomy .


The aim of this study was to determine the way of infection , pathohistological changes of the liver , virus genotype presence and sustained virological response after pegylated interferon and ribavirin therapy in prison inmates .


We recruited 148 participants .


Secondary self-report outcome measures include : the proportion of single and multiple fallers and time to first fall over a 12-month period ; Short Falls Efficacy Scale-International ; fear of falling in the past 4 weeks ; Frenchay Activities Index ; fracture rate ; Geriatric Depression Scale ; EuroQoL-five dimensional scale 3-L ; health service utilisation at 6 and 12 months .


Gestational weight gain , postpartum weight retention and breastfeeding .


Patients with lumbar radicular pain have a substantial pain reduction during 1-year follow-up , but Modic type I changes may imply a slower initial decrease in sensory pain .


Baseline characteristics were well balanced .


Preventive SLIT is safe in children 2-5 yr of age and induces regulatory mechanisms involving allergen-specific IgG and IL10 .


Eligible patients had head and neck cancers requiring palliative chemotherapy with ECOG PS 0-2 and adequate organ functions who could not afford cetuximab .


Adjusted linear regression coefficients indicated that household availability of ultra-processed products was positively associated with both the average BMI and the prevalence of excess weight and obesity , whereas processed products were not associated with these outcomes .


The primary outcome was recurrence of EV .


Therefore , 409 women in the intervention group and 408 controls were analysed for the primary outcome .


Subjects were assessed with measures of nicotine and gambling severity and followed for 3 months after treatment .


This study sought to examine the utility of hair testing as a research measure of drug use among individuals with moderate-risk drug use based on the internationally validated Alcohol , Smoking , and Substance Involvement Screening Test ( ASSIST ) .


Eighty-two patients ( aged 16-35 ) will be recruited for the study .


Parallel group randomized single institution trial , on gynaecologic malignancies patients conducted in Catholic University of Sacred Heart Rome , between April 2009 and November 2011 .


We tested the efficacy of a brief intervention to promote correct and consistent use of condoms among Black male youths attending sexually transmitted infection ( STI ) clinics in 3 southern US cities .


20 half-hour sTMS sessions were administered 5 days per week for 4 weeks .


The KOOS results were lower for patients with OA in all subscales , indicating that OA was symptomatic .


We studied effects of inorganic nitrate , in amounts that represented a diet rich in vegetables , on the RMR in healthy volunteers .


Secondary endpoint was change in plain radiographic damage scores .


We measured spasticity with Modified Ashworth Scale , related disability with Disability Assessment Scale , and fingers position at rest .


Haemodiafiltration ( HDF ) with high reinfusion volumes is the most effective technique for clearing uraemic toxins .


Both surgeries resulted in quick visual recovery as early as 1 week postoperatively .


WBV ( 50 Hz ) can augment cross-transfer in neuromuscular performance .


Cerebrospinal fluid leakage ( 9.7 % vs 17.2 % , OR 0.53 [ 95 % CI 0.23-1 .15 ] , p = 0.108 ) and infection ( OR 0.18 [ 95 % CI 0.01-1 .18 ] , p = 0.077 ) occurred less frequently in the study group than in the control group .


All original slides were requested , and a specialized central pathology review was performed by experienced gynecopathologists .


CaO2 , CcvO2 , ERO2 and Lac between the two groups were no significant difference ( P > 0.05 ) .


We evaluated the effect of pasireotide , a novel SA with high affinity for 4/5 human somatostatin receptors , on pathophysiological events and symptoms in dumping .


Participants with the lowest genetic risk of having long-term elevated homocysteine levels , but with higher measured homocysteine levels , had the highest PWV levels .


BC schools during efficacy trials , the BC government supported a provincial scale-up .


The supplementation group were daily assigned to 1 500 IU VA and 500 IU VD for 3 months .


Guesstimates of treatment group assignment were completed by site investigators , research coordinators and patients at the end of study follow-up .


We noted no statistical significant differences in eradication rates among four regimens .


Observationally lower testosterone is associated with an unhealthier cardiovascular ( CVD ) risk profile , but this association is open to confounding and reverse causality .


Furthermore , medical assistance and severe complications were assessed .


Nitrous oxide inhalation was the predictor variable , whereas the hemodynamic changes , amount and concentration of propofol , and adverse events were the outcome variables .


Clinical data were recorded to compare feeding condition , physical growth , blood biochemical indices , and major complications between different groups .


Participants received single doses of cinacalcet alone or in combination with either CaCO ( 3 ) , sevelamer HCl or pantoprazole .


We assessed the efficacy of palbociclib ( an inhibitor of CDK4 and CDK6 ) and fulvestrant in advanced breast cancer .


The primary outcome was defined as a 7-day point prevalence of self-reported no smoking verified by expired carbon monoxide level < 10 ppm at 12 weeks .


Compared to other groups , patients on antidepressants at both baseline and follow-up assessment showed the smallest improvement in mood symptoms and HRQoL .


Although R. rosea produced less antidepressant effect versus sertraline , it also resulted in significantly fewer adverse events and was better tolerated .


No consistent pattern of improvement in diastolic function at rest or during exercise was seen .


Chief Scientist Office ( Scottish Government ) , Breast Cancer Institute ( Western General Hospital , Edinburgh ) .


Using two-dimensional echocardiography , RV FAC was measured in the apical four-chamber view .


Vitamin E treatment was well-tolerated with no serious adverse events in the present study .


Radiation doses of flat-panel CT and MDCT were recorded using thermoluminescent dosimeters .


INTERVENTIONs included dietary advice , coaching , and exercise during pregnancy .


Similarly the mean total duration of anaesthesia for the volar subcutaneous group was 271.9 29.34 minutes while for the dorsal two injections group , it was 229.52 28.82 minutes ( p = 0.415 ) .


Neither patients nor investigators were masked .


Daytime sleepiness was assessed using the Epworth Sleepiness Scale ( ESS ) .


Selective factor Xa inhibitors , such as fondaparinux , which has a favourable benefit-risk profile in the prevention and treatment of venous thromboembolism and the management of acute coronary syndromes , have not been systematically evaluated in this setting .


NTR2344 , www.trialregister.nl .


The protocol was approved by the Institutional Review Board of each hospital .


Median follow-up time was 5.2 ( range : 3.8-6 .2 ) years .


The majority of recurrences occurred during the first year ( PVAC 79 % vs. CPVI 70 % , P = NS ) .


To investigate the efficacy of a proactive feeding regimen ( PFR ) in reducing hospital length of stay in a population of moderately preterm small for gestational age ( SGA ) infants .


More than 70 % of surgeons preferred the use of stents in unfit patients for palliation , and preferred surgery in fit patients with curable disease .


Mixed methods were used to evaluate the implementation process .


Among maintenance dialysis patients with hypertension and left ventricular hypertrophy , atenolol-based antihypertensive therapy may be superior to lisinopril-based therapy in preventing cardiovascular morbidity and all-cause hospitalizations .


Wood smoke exposure does not impair vascular vasomotor or fibrinolytic function , or increase thrombus formation in fire fighters .


The individuals with three polymorphisms in eNOS gene had increased concentration of serum folate and decreased concentration of p-tHcy after folic acid supplementation .


Results are discussed in the context of cumulative adversity and self-trauma theory .


The related clinical indicators of the two group were observed .


The limited use of a tourniquet in TKA provides the benefit of decreased limb swelling and knee joint pain while not compromising the operation time or blood loss and recovery .


Somatic EPM by heterotopic stimulation significantly decreased foot pain in controls ( p = 0.004 ) , but not in FD ( p = 0.80 ) .


Increased gastric volumes and delayed emptying are possible but unexplored mechanisms .


This analysis tests the effectiveness of HR-VG ( versus wait-list control ) for reducing sexual risk behavior among WLH and explores intervention satisfaction .


Significant correlations were observed among changes in perceived stress , sleep problems , mindfulness , and self-compassion .


While the experimental group had significantly lower ( P < .05 ) second post-test scores compared with the first post-test scores , no significant difference ( P = .94 ) was found between these two scores for the control group .


Albumin and RBP concentrations were within the age-specific reference range for all children .


The median time to prostate-specific antigen progression was 4.7 months ( 95 % confidence interval 3.7-8 .3 ) ; the median overall survival was 11.8 months .


Manipulations were performed at least 20 times per day and the stimulation of the newborn 's foot / feet byparent finger was performed at least 100 times per day .


Rifampicin and protease inhibitors are difficult to use concomitantly in patients with HIV-associated tuberculosis because of drug-drug interactions .


We counted any detected new hemorrhage ( catheter tract hemorrhage or any other distant hemorrhage ) on computed tomography scan within 30 days from the randomization .


To investigate the effectiveness of combining exercise and psychotherapy in improving acute depressive symptoms among older adults who were receiving treatment in an inpatient psychiatric unit .


Recurrent respiratory infections ( RRI ) constitute a social problem for both the pharmaco-economic impact and the burden for the family .


Further studies were therefore indicated .


At the end of follow up , the recurrence rates were 13.1 % in group A and 24.0 % in group B. No statistical significance was found between two groups regarding the recurrence rates at each time point ( P > 0.05 ) .


This high-energy , Q-switched Nd : YAG laser with a continuously variable spot-size safely and effectively removes tattoos , with greater removal when using a larger spot-size .


Patients in the UC arm will be followed up at the outpatient clinic , with management according to current heart failure guidelines .


The primary endpoint was the number of doses and amount of postoperative fentanyl administered postoperatively for rescue analgesia .


After adjusting for exposure , only higher levels of anti-EBA-175 IgG were significantly associated with reduced clinical malaria incidence ( IRR 0.67 , p = 0.0178 ) .


Next , we utilized the National Health Interview Survey ( NHIS ) , which inquired about smoking history and race/ethnicity , to analyze the demographic profiles of various high-risk smoking history categories .


Patients also received IV colistin in both arms .


In vivo multimodality in situ imaging was performed over a 3-week period using in vivo Optical Coherence Tomography ( OCT ) and Non-Linear Optical microscopy ( NLOM ) .


IFX detection was comparable between assays ( 82 % RIA , 76 % ELISA , 88 % HMSA , and 74 % RGA ) , and it correlated significantly ( Pearson 's r = 0.91-0 .97 , P < 0.0001 ) .


It took an average of 6 months for patients to reach their SBP target , sustained to the last follow-up .


AF is responsible for up to a quarter of all strokes and is often asymptomatic until a stroke occurs .


A portable ultrasound device , BladderScan BVI 6400 ( Verathon Inc , Bothell , WA ) , measured BVs at treatment planning computed tomography ( TPCT ) scan and 3 times per week during RT. .


We propose to test the effectiveness of a home-based intervention on infant feeding practices , nutrition and health outcomes of infants born in two slums in Nairobi , Kenya .


However , there is also evidence that lower extremity strength training might lead to such improvements .


Outcomes included total invasive cancer , breast cancer , and colorectal cancer , and cancer-specific and overall mortality .


Similarly , the 3-17 - androstenediol glucuronide serum levels were decreased by 34.8 % in patients with IH , and by 47.5 % in patients with PCOS ( P < .0001 , respectively ) .


Preventive arthroscopic DCR is not recommended in patients with radiological but asymptomatic ACJ arthritis .


The objective of this post hoc analysis of our randomized control trial was to determine whether rapid diagnosis and treatment of IS could limit the incidence of ASD while identifying risk factors related to ASD outcome .


The cross stability increases the pressure in the median ball area , prevents the unnatural inverted position of the forefoot and thus creating an effect which is comparable to walking barefoot .


Three out of twenty mini-implants in the RVG group showed root contact in the mandibular arch that may be attributed to the narrower interradicular space and reduced accessibility in the mandibular posterior region .


The positive electrode was placed on the second lumbar spinous process , and the negative electrodes were inside the middle and lower third of the junction between the posterior superior iliac spine and ischia node .


Trends toward transfusion differences between groups were not statistically significant .


We measured brachial BP ( bBP ) , central BP ( cBP ) , GFR , urinary output ( OU ) , free water clearance ( CH2O ) , fractional excretion of sodium ( FENa ) , urinary excretion of albumin ( UAER and UACR ) , AQP2 ( u-AQP2 ) and ENaC ( u-ENaC ) and plasma concentrations of vasoactive hormones : renin , angiotensin II , aldosterone , arginine vasopressin , endothelin-1 and brain natriuretic peptide .


In addition to assessing outcomes adjusted for the hierarchical design , mediation analyses will be used to deconstruct and confirm the program 's theoretical underpinnings and intervention processes .


The postoperative pain score and rescue fentanyl consumption were higher in SPI-guided group ( 7 [ 4.5 ; 9 ] vs. 3 [ 2 ; 6.75 ] ; P = 0.002 ; 0.50 0.34 vs. 0.29 0.30 g/kg ; P = 0.04 ) .


Ninety healthy male volunteers were enrolled ( n = 18 per arm ) .


Seventy aged edentulous patients with severe residual alveolar ridge resorption were recruited in this study and randomly assigned into two groups , thirty-five each .


Clinical Trials Registry of India ( CTRI/2010/091 / 002916 and CTRI/2011/04 / 001696 ) .


DDAVP can increase the level of von Willebrand factor and coagulation factor VIII , thus it may enhance PLT function and improve coagulation .


Daily number of bowel movements changed from a median of 7 ( interquartile range [ IQR ] , 5-10 ) the day prior to FMT to 2 ( IQR , 1-2 ) after the infusion .


After adjustment for baseline inflammatory biomarker concentrations , there were no significant differences between patients who received transfusion and those who did not .


It has displayed increased binding affinity and a longer dissociation time when compared to rituximab resulting in improved complement dependent cellular cytotoxicity ( CDCC ) ; a mechanism with the potential to overcome apoptosis-resistance in TP53 disruption .


The proportion of appropriate punctures , defined a priori as 030 from midline , was significantly higher : 20 ( 87 % ) of 23 versus 12 ( 50 % ) of 24 ( RR = 1.74 ; 95 % CI = 1.13 to 2.67 ; P = 0.006 ) .


Treatment intensification occurred in 52 % of group medical clinic patients , versus 37 % of usual care patients between study baseline and end ( P = .04 ) .


Following the walnut test meal , the incremental 5 hour area under the curve ( AUC ( 0-5h ) ) was reduced 7.4 % for MDA , increased 7.5 % for hydrophilic and 8.5 % for lipophilic ORAC and comparable for total phenols , FRAP and uric acid .


Adjusted for possible confounding factors , the SSC effect on complications remained significant with odds ratio 1.95 ( 95 % confidence interval , 1.59-2 .40 ) .


The objective of this study is to determine whether budesonide via MAD affects the hypothalamic-pituitary-adrenal ( HPA ) axis .


2 , 4 , 8 , 12 , 16 , 24 and 72 hours after the release of the tourniquet the level of pain was assessed by the visual analogue scale ( VAS ) .


Assess the steady-state pharmacokinetics , pharmacodynamics and safety of once-daily ( q.d. ) versus twice-daily ( b.i.d. ) dosing with canagliflozin at the same total daily doses of 100 and 300 mg in healthy participants .


Nested prospective cohort study .


The quality of the working alliance was positively associated with improvements in physical and psychological community integration and quality of life .


In this prospective , interventional case series , 30 toric , aspheric Bi-Flex T toric IOLs ( Medicontur Medical Engineering Ltd. , Inc. , Zsmbk , Hungary ) were implanted in 20 consecutive patients with topographic corneal astigmatism between 1.50 and 4.00 diopters ( D ) and evaluated within the first year after implantation .


The adjusted hazard ratio ( HR ) for group A2 versus A1 was 1.37 ( 95 % CI , 0.7 to 2.5 ; P = .311 ) .


For 8 % arginine on days 3 and 4 ( post-acid ) , the proportion was 78 % ( SD : 8 % , CI = 74 % to 82 % ) .


The present study included participants from 3 Nordic SYSDIET centers [ Kuopio ( n = 20 ) , Lund ( n = 18 ) , and Oulu ( n = 18 ) ] with a maximum weight change of 4 kg , highly sensitive C-reactive protein concentration < 10 mg/L at the beginning and the end of the intervention , and baseline body mass index ( in kg/m ) < 38 .


In the subgroup ( n = 131 ) with hand and/or foot psoriasis [ baseline 5-point hand/foot Investigator 's Global Assessment ( IGA ) score 2 ] , efficacy was assessed as percentage of subjects achieving an IGA response [ a score of 0 ( clear ) or 1 ( minimal ) and an improvement of 2 points on the 5-point hand/foot scale vs. baseline ] at Week 12 .


Participants from the ACCORD-MIND and ACCORD-Eye substudies were included in analyses of cognition ( n = 1,862 ) and MRI-derived brain variables ( n = 432 ) .


Researchers were not blinded to groups .


After 4 - to 12-week pharmacotherapy optimization , 39 patients with left ventricular ejection fraction ( LVEF ) of 45 % received injections of BMMC or vehicle intra-operatively into the myocardial infarction border area in a randomized , double-blind manner .


Leak pressure was lower with LMA-S ( 23.310.8 cm H2O , 95 % CI 20.2-26 .4 ) than with LTS-D ( 28.913.9 cmH2O , 95 % CI 24.4-33 .4 ; P = 0.047 ) .


3D LGE acquisitions were performed in 17 patients prior to radio frequency ablation of persistent AF both with and without dynamic-TI .


Relative to the CON , the PRO produced 100 % ( 95 % CI : 85 % , 115 % ) energy compensation , whereas the CAL produced significant overcompensation [ 118 % ( 95 % CI : 104 % , 133 % ) ] , which was significantly more positive than with the PRO ( P < 0.05 ) .


Women randomly assigned to ET had a significant reduction in the primary endpoint , ( hazard ratio : 0.74 ) compared with men ( hazard ratio : 0.99 ) randomly assigned to ET , with a significant treatment-by-sex interaction ( p = 0.027 ) .


Response rates of questionnaires were 84.4 % ( 168/199 ) after 3 months and 75.4 % ( 150/199 ) after 12 months .


A rat model of dexamethasone ( DEX ) induced muscle atrophy and a human 56-day bed rest study with and without vibration therapy were used to assess biological and clinical relevance .


This AK is presumed to have a diagnostic capability .


We randomly assigned 3,755 all-comers receiving PCI to PtCr-EES or CoCr-ZES .


Eleven patients ( 39 % ) had an in-field relapse , 7 patients ( 25 % ) relapsed outside the irradiated volume , and an additional 10 patients ( 36 % ) showed mixed in - and out-field relapses .


Control eyes received Maxidex ( ) ( dexamethasone ) .


Already 5 minutes into the treatment , the difference ( 1.9 points ) was significant ( P = .007 ) .


2 .


Dilation was successful in 69 patients ( 93.2 % ) , and the average periprocedural pain level was 3.2 ( scale of 0 to 10 ) .


Patients undergoing PD were randomized to receive either a duct-to-duct PJ or a double-layer invaginated PG .


However , self-limited diarrhoea was more frequent in LGG patients .


Reaching and maintaining a target weight between the 15th and 20th BMI percentile is favorable for the resumption of menses within 12 months .


Between Nov 1 , 2010 , and Dec 31 , 2011 , after exclusion of women who were ineligible , we enrolled and randomly allocated 515 women to methylation triage and 509 to cytology triage .


Pain score on postoperative day 1 and 2 was significantly higher in RIRS , but patients with SWL required significantly more analgesics afterward .


We developed a behavioral cessation program for willing-to-quit waterpipe users , and evaluated its feasibility and efficacy in a pilot , two arm , parallel group , randomized , open label trial in Aleppo , Syria .


Goal-directed fluid therapy during hip fracture repair under spinal anaesthesia does not result in a significant reduction in length of stay or postoperative complications .


3 .


Wnt-Tcf4 pathway genes were expressed in both epithelium and stroma but differed by subcellular location .


The mean annualised atrophy rate was significantly lower in patients in the simvastatin group ( 0288 % per year [ SD 0521 ] ) than in those in the placebo group ( 0584 % per year [ 0498 ] ) .


There was an improvement in oral hygiene , as measured by the OHI-S , and an increase in brushing frequency for all children , regardless of whether their parents were educated with or without a visual aid .


Normal-weight subjects showed significant blood oxygen level-dependent responses in the ventromedial prefrontal cortex ( vmPFC ) to food aromas compared with responses induced by the odor of an inedible object .


Significant improvement was found in all variables within group ( p < .05 ) in Rusie Dutton group , and a significant difference between groups was found ( p < .05 ) in all variables except BW and BMI .


The frequency of occurrence in a group of patients undergoing general anaesthesia for uncomplicated Caesarean section is not higher than for other procedures .


The presented model for testing cleansing preparations allows a highly controlled , practically relevant and reproducible irritancy assessment of occupational skin cleansers .


Quality-controlled fMRI data from 42 patients and 42 healthy subjects ( HS ) were obtained .


Among 425 chronically HCV-infected male veterans , 155 ( 37 % ) had advanced fibrosis and 180 ( 42 % ) had advanced inflammation .


In this prospective , randomized , double-blind study , 120 ASA I and II patients undergoing selective uvulopalatopharyngoplasty under general anesthesia were included .


In addition , lafutidine was superior to famotidine in clinical improvement ( 53.73 % vs. 39.55 % , P = 0.0200 ) .


The final model was developed by backward elimination , followed by exclusion of covariates determined not to be of clinical relevance to ipilimumab , and was rigorously validated against both internal and external datasets .


The participants were randomly divided into 3 groups based on the application of drops .


Body mass modified the relationship between time to fatigue and drink ingestion ( p = 0.02 for drink body mass ) , such that lower body mass was associated with increased time to fatigue when the players ingested CHO , but not placebo .


Previous observations have shown that this can lead to an increase of complications , such as an abnormally long labour , maternal and fetal exhaustion , instrumental delivery , severe perineal tears , and emergency caesarean section .


The week 8 mean change in HAM-A total score was not statistically significant for quetiapine XR ( 10.74 ; P = .079 ) vs placebo ( 9.61 ) .


In contrast to previous studies , we designed a pragmatic trial ( as opposed to explanatory trials ) to mimic real practice and obtain maximal external validity for the study .


At these sites , we continued to enrol infants younger than 7 days until March 29 , 2013 .


Repositioning failed in two ( 5.1 % ) patients .


Inclusion criteria were clinical and laboratory signs of ALF : serum total bilirubin level > 180 mkmol/L , 2-fold increasing serum aspartate aminotransferase ( AST ) and alanine aminotransferase ( ALT ) , low serum cholinesterase and high serum ammonia levels .


The Infant Aphakia Treatment Study is a randomized clinical trial with 5 years of follow-up that involved 114 infants with unilateral congenital cataracts at 12 sites .


Standardised checklists will be completed by group leaders and each training session will be videotaped to assess fidelity to model .


Follow-up continued until September 2013 .


The experiment was conducted from November 2011 to May 2012 at the University Hospital Basel ( Switzerland ) with 42 medical students in a master 's program .


Adherence to evidence-based cardiovascular ( CV ) medications after an acute myocardial infarction ( MI ) is low after the first 6 months .


Numerically comparable reductions were seen for central aortic systolic pressure ( CASP ) in aliskiren-based therapy ( baseline : 143.715.0 ; week 36 : -20.316.2 ) compared with ramipril-based therapy ( baseline : 147.911.9 ; week 36 : -20.714.6 ) .


Grade 4 acute genitourinary toxicity was reported for two patients , one ( < 1 % ) in each group .


E-mail invitations were sent to parents of children aged 5 to 8 years enrolled in the Interactive Autism Network .


Arthroscopic subacromial decompression may cause substantial postoperative pain .


Inclusion of bone replacement graft suppressed new bone formation during early healing .


We aimed to assess these attitudes via a survey .


Sixty male Wistar rats were randomly divided into six groups as sham ( n = 10 ) , ischemia-reperfusion ( n = 10 ) , exercise ( n = 10 ) , exercise plus ischemia-reperfusion ( n = 10 ) , ischemic preconditioning ( n = 10 ) , and ischemic preconditioning plus ischemia-reperfusion groups ( n = 10 ) .


Randomization will be done by the cluster randomization of wards .


Treatment response to rTMS was shown to be related to changes in SICI that might reflect modulation of GABAergic mechanisms directly or indirectly related to rTMS treatment effects .


Data collection and thematic analysis were guided by Normalisation Process Theory ( NPT ) .


Both control and high-stress scenarios triggered significant stress responses among participants ; however , stress responses were not significantly different between control and high-stress conditions .


These results demonstrate that topical unoprostone might have a therapeutic efficacy in patients with RP as a consequence of the macular bloodflow improvement as well as its direct neuroprotective effect .


A total of 407 children and adults with persistent asthma receiving first-time care in pulmonary and allergy practices at 4 urban medical centers were randomized to receive either written instructions ( n = 204 ) or no written instructions other than prescriptions ( n = 203 ) from physicians .


Inhalation of nebulized 5 % and 3 % hypertonic saline could decrease clinical symptoms of patient with acute bronchiolitis ; 5 % HS was superior to 3 % HS .


To assess the cardiorespiratory parametes , recovery , gastrointestinal motility and serum cortisol concentrations in horses anesthetized with isoflurane with or without a continuous rate infusion ( CRI ) of butorphanol for orchiectomy .


Data regarding BIS monitoring and recovery in an exclusively cardiac surgery population are consistent with recent effectiveness studies in the general surgical population .


This study examined whether telephone counselling for parents and subsequent parental smoking cessation affect smoking-related cognitions and smoking initiation among children of smoking parents .


French general practitioners ( GPs ) were invited to participate and were blinded to the study 's aim .


In 95 wrists , a second NCS was done 12 months post-treatment .


Stress-relieving effects of balneotherapy compared to progressive muscle relaxation ( PMR ) and to resting were investigated by measuring subjective relaxation and salivary cortisol .


( 2 ) The effective rates 20 min after the first treatment , after 5 weeks ' and 3 months ' treatment in the abdominal acupuncture group were better than those in the auricular point group [ 31.4 % ( 27/86 ) vs 0 % ( 0/82 ) .


Thirty patients were scanned with the new TRO-CTA protocol ; after the coronary scan with retrospective ECG-gating , non-ECG-gated whole-chest CTA was performed at 80 kVp to evaluate aortic arch ( AAr ) and pulmonary trunk ( PT ) .


Logistic regression was used to model prolonged abstinence from smoking ( ascertained by self-report and breath carbon monoxide testing ) as a function of treatment , baseline ADHD Rating Scale-IV ( ADHD-RS ) score , change in ADHD-RS score during treatment , and their interactions .


A 500 ml pre-load may not affect discharge but did not increase micturition problems for chloroprocaine .


Direct medical costs as well as indirect costs will be considered.Subjects are randomly allocated into two treatment arms : 1 ) Symptom-guided treatment ( patient controlled ) , receiving care when patients feel a need .


The complication rates decreased from 19.9 % to 11.5 % ( P < 0.001 ) , with absolute risk reduction 8.4 ( 95 % confidence interval , 6.3-10 .5 ) from the control to the SSC stages .


The aim of this prospective study was to compare the effect of administering lidocaine versus amiodarone before aortic declamping during elective coronary bypass grafting , paying close attention to when the initial effect of amiodarone sets in .


impact of NMS on : patients ' understanding of their medicines , pharmacovigilance , interprofessional and patient-professional relationships and experiences of service users and stakeholders.Economic analysis : Trial-based economic analysis ( cost per extra adherent patient ) and long-term modeling of costs and health effects ( cost per quality-adjusted-life-year ) will be conducted from the perspective of National Health Service ( NHS ) England , comparing NMS with current practice.Qualitative analysis : a qualitative study of NMS implementation in different community settings , how organizational influences affect NMS delivery , patterns of NMS consultations and experiences of professionals and patients participating in NMS , and patients receiving current practice .


A total of 134 participants were enrolled and randomized .


The motor therapy program incorporating the nonparetic side along with the affected side was found to be effective in enhancing balance and function in stroke .


The authors implemented a prospective , single-blinded , randomized clinical trial .


Watermelon supplementation reduced aortic BP and myocardial oxygen demand during CPT and the magnitude of the cold-induced increase in wave reflection in obese adults with hypertension .


The primary outcome of baseline-adjusted ISSI-2 at 48 weeks was higher in the liraglutide group than in the placebo group ( 339.8 27.8 vs. 229.3 28.4 , P = 0.008 ) .


We aimed to assess the efficacy , safety , and effective treatment duration of grazoprevir ( an HCV NS3/4A protease inhibitor ) combined with elbasvir ( an HCV NS5A inhibitor ) with or without ribavirin in patients with HCV genotype 1 infection with baseline characteristics of poor response .


To investigate the effectiveness of an intensive nursing care electronic followup system for cardiovascular risk management after percutaneous coronary intervention ( PCI ) .


The trial is designed to provide 90 % power for the primary end point .


Supplementing the OLT with both the ME intervention and the LC significantly improved attitudes and clinical proficiency in comparison to OLT alone .


Treatment-seeking cannabis-dependent adults ( n = 38 ) were admitted for 8days to an inpatient withdrawal unit and randomized to either oral lithium ( 500mg ) or placebo given twice a day under double-blind randomized controlled trial ( RCT ) conditions .


Therefore , novel evidence-based controlled interventions are necessary to evaluate models for prevention and treatment based on self-management .


The sensitivity analysis revealed that there is an 85.8 % probability that HL is cost-effective if decision-makers are willing to pay $ 50,000 .


Included implicit self-esteem measures were either popular or provided methodological improvements upon older methods .


Landmark analyses compared progressing patients with those who had not progressed .


The Model 's discriminating ability was assessed using receiver operating characteristic curve analysis , which showed that the area under the model curve ( standard error ) was 0.86 0.04 ( 95 % confidence interval , 0.77-0 .94 ) .


322 ( 62 % ) of 518 patients previously treated with docetaxel had grade 3-4 adverse events , compared with 205 ( 54 % ) of 383 patients without docetaxel .


Therefore , new protocols , including an improved anesthetic regimen , are required .


The percentage of persons with SA increased significantly with the symptom score after 1 year , and the duration of SA remained significantly longer after 2 years of follow-up between the multiple somatic symptoms groups .


Attributable costs and length of stay for each complication were calculated by multiplying the independent cost of each event by its frequency in the treatment group .


Cirrhosis of liver is the leading cause of portal hypertension in this part of the globe .


A score 3 ( in an improvement scale from -5 to +5 ) defined success .


After 1 year in the program and after adjustment for confounders , intervention group households proved more likely ( P 0.05 ) than control households to have undergone physical examinations , blood pressure monitoring , and cervical cytology screenings .


HPV-16 and HPV-33 have by far the highest risk of progression to CIN3 + , and HPV-16 and HPV-31 have the lowest chance of clearance .


37 pts were enrolled ( 18 to LAP+CAP , 19 to LAP ) .


Gadofosveset trisodium exhibited a larger T1c field and T1c tissue than did Gd-DTPA .


Subjects with a LH-MDD are susceptible to developing depressive symptoms during smoking cessation , regardless of pharmacologic aid .


After the consultation , both physicians and patients independently completed questionnaires based on the D-Option scale regarding SDM behaviors during the consultation .


Hierarchical linear models and multiple regression models assessed individual - and center-level changes in knowledge , policies , practices and age - and sex-specific standardized body mass index ( zBMI ) , controlling for state , parent education , and poverty level .


Thirty-six patients who underwent coronary bypass surgery were randomized into integrated ( Group In ) and nonintegrated arterial line filter ( Group NIn ) groups .


Statistical analysis of survey data did not identify significant post-program differences between groups .


There was no significant difference in perinatal mortality [ 19/28 vs. 19/28 ; relative risk ( RR ) 1.0 ; 95 % confidence interval ( CI ) 0.70 to 1.43 ] , maternal morbidity or neonatal morbidity .


Twenty-two post-stroke patients were randomly allocated to control or experimental groups .


Alcohol accelerates the course of hepatitis C ( HCV ) infection and liver damage .


In phase 2 , 12 doctors from specialties with high-volume prescribing of gentamicin were interviewed .


The time-course and magnitude of both placebo and varenicline craving response were characterized by a large degree of unexplained variability .


Workers potentially over-exposed to airborne respirable crystalline silica were identified at most of the worksites evaluated .


The frequency of objective VMS was also reduced to a greater degree in the SGB group than in the sham group ( event rate ratio , 0.71 ; 95 % CI , 0.64-0 .99 ; P < 0.05 ) .


These improvements were sustained to 36h post-dose .


Transition from epoprostenol with glycine and mannitol excipients to epoprostenol with arginine and sucrose excipients did not affect treatment efficacy , raised no new safety or tolerability concerns , and provided patients with an increased sense of treatment convenience .


Mobile health strategies could address this gap but lack evidence of therapeutic benefit .


There were no significant changes in moderate-to-vigorous physical activity , sedentary time , or functional performance .


Whether these impacted women 's behaviors and may have contributed to ineffective trial results warrants further investigation .


Primary end point was the incidence of malaria attacks during the follow up period .


We investigated the efficacy of adding once-daily rapid-acting insulin in Japanese diabetes patients treated with basal-supported oral therapy .


The purpose of this study was to examine the effect of a strategy of EG LV lead placement in each of ischemic ( ICM ) vs nonischemic ( NICM ) cardiomyopathy patients .


Increasing MPV values may reflect increased intraabdominal pressures , which may have a clinical implementation in intraabdominal hypertension .


In 2000 , an estimated 7.4 % ( 95 % confidence interval , 6.9-7 .9 ) of adult Americans were prescription opioid users compared with 11.8 % ( 95 % confidence interval , 11.2-12 .4 ) in 2010 .


If it is possible to confirm significant clinical benefit and/or cost-effectiveness , this would have direct implications for the management of this distressing and costly complication of diabetes


At 12 months after discharge , those who reported NM-PO ( odds ratio [ OR ] , 2.31 ; 95 % confidence interval [ CI ] , 1.28-4 .15 ) and drug use ( OR , 2.62 , 95 % CI , 1.70-4 .04 ) before admission had the highest odds for postdischarge NM-PO .


The aim was to compare the hemodynamic parameters , intubation times , upper airway trauma and postoperative sore throat scores of the patients with normal airway anatomy , intubated with the Airtraq , Macintosh laryngoscope and fiberoptic bronchoscope , by experienced anesthesiologists .


Compared with low-risk months , and 95 % confidence intervals ) of HF hospitalizations during medium-risk months was 2.9 ( 2.0-4 .4 ) and during high-risk months was 10.7 ( 6.9-16 .6 ) .


We performed a prospective economic evaluation comparing FFR vs. ANGIO in patients with multivessel disease based on original patient-level FAME data .


Groups were similar with respect to age , gender , weight , pre-existing renal dysfunction , hypertension , medication , and baseline serum creatinine and serum cystatin C , but diabetes mellitus was significantly less prevalent in group 1 .


Owners assessed visual analog scale ( VAS ) scores of pruritus on days 0 , 1 , 2 , 7 , 14 , 28 , 56 , 84 and 112 .


ETs had higher e ' lateral at rest ( 18.1 2.7 vs 16.3 3.3 cm/sec , P = .02 ) and higher mitral E ( 141 15 vs 132 15 cm/sec , P = .02 ) and e ' lateral ( 23.5 2.5 vs 21.4 3.0 cm/sec , P = .01 ) with exercise than NAs .


The purpose of this study is to evaluate the effectiveness of a multifactorial intervention program to modify frailty parameters , muscle strength , and physical and cognitive performance in people aged 65 years or more .


Preoperative therapy with chemotherapy and the HER2-targeted monoclonal antibody trastuzumab is valuable for patients with large or locally advanced HER2-positive ( HER2 + ) breast cancers but traditional methods of measuring HER2 expression do not accurately stratify patients for likelihood of response .


408 facial , high risk ( diameter at least 1cm , H-zone location or aggressive histological subtype ) primary BCCs ( pBCCs ) and 204 facial recurrent BCCs ( rBCCs ) were randomly allocated to treatment with either SE or MMS between 5th October 1999 and 27th February 2002 .


A prospective , open , randomized , controlled study was carried out on 595 cases of infants who exhibited wheezing after a respiratory syncytial virus infection .


Although the primary analysis did not show a significant difference in 10-year success rates comparing donor ages 12 to 65 years and 66 to 75 years , there was evidence of a donor age effect at the extremes of the age range .


This study included 86 infertile men with idiopathic oligoasthenozoospermia , who were randomized to a VD and a control group of equal number , the former given oral VD 200 IU/d and calcium 600 mg/d , qd , while the latter administered oral vitamin E 100 mg and vitamin C 100 mg , tid .


Each participant was assessed using a paediatric cancer coping scale and perceived symptom severity was evaluated at three time points ( baseline , 1 month and 3 months ) .


Supervision was more effective than SMS or routine surveillance in improving AEFI reporting rate .


Measurement of HAMD was repeated in 4-week interval .


A decreased ERN following ethanol administration is in line with previous work and offers further support for the impairing effects of alcohol intoxication on performance monitoring .


Red ginseng is prepared by steaming raw ginseng , a process believed to increase the pharmacological efficacy .


The objectives were to assess the suitability of the methodology , produce a sample size calculation for a full RCT , and to give an indication of cost-effectiveness for both pathways .


For early stage HCC , treatment options include surgical resection , liver transplantation , and percutaneous ablation .


Participants made less mistakes ( M ) overtime : M ( T0 ) = 3.2 and M ( T6 ) = 2.6 for the intervention group , and M ( T0 ) = 4 and M ( T6 ) = 2.40 for the control .


The aim of PREDNOS 2 is to evaluate the effectiveness of a 6-day course of daily prednisolone therapy during an URTI in reducing the development of a subsequent relapse in a developed nation .


Over 39 20 months , 140 of 447 ( 31.3 % ) patients met the RAFT primary end point ( death or HF hospitalization ) .


The QoL was assessed by the application of the WHOQOL-Bref , and the SF-36 was used to assess the HRQoL .


This study aimed to determine whether breathing helium-hyperoxia could increase the tolerance of a high-intensity exercise session achieved by 1-legged cycling .


clinicaltrials.gov Identifier : NCT00413946 .


In the IBGMS group , the A1C level decreased from 8.79 % 1.25 % to 7.96 % 1.30 % ( p < 0.05 ) .


Moreover , we evaluated inflammatory patterns in prostatic specimens at final pathology .


Fostering patients ' sense of meaning is an essential task for palliative care clinicians .


Geometric mean anti-HBs titres were similar for placebo ( 114.4 IU/L ) and vedolizumab ( 129.6 IU/L ) at day 74 .


Eighty patients with schizophrenia were randomly assigned to a music intervention group ( MIG ) or usual care group ( UCG ) .


The primary outcome was successful cannulation of the radial artery in 4 or less attempts .


In the acupuncture group , the filiform needles were inserted obliquely at 45 degrees and retained for 40 min in each treatment .


This finding suggests that the switch to a rilpivirine-based regimen should not be recommended .


Within treatment arms , changes in the level of HbA1c were compared by paired t-test .


Mean elimination half-life for total RCT-18 and free RCT-18 was 5.7-12 .8 days and 3.2-11 .3 days at 6-60mg , and 15.1-17 .5 days and 18.8-36 .8 days with 180-540mg RCT-18 .


LVEF was decreased along with the prolongation of chemotherapy in the experimental group and control group .


All patients had a self-expanding polymer stent placed prior to NAT .


A total of 480 completed all study .


The purpose of this study was to examine whether pioglitazone , given with insulin , preserved cell function in patients with new-onset T1DM .


The combination of active posture correction and trunk movements , muscle stretching , and proprioceptive stimulation may usefully impact PD axial symptoms .


The primary endpoint was late lumen loss ( LLL ) at nine months .


Total healthcare costs and healthcare utilisation data for both the primary and the secondary healthcare sector were retrieved from public registries from randomisation - September 2011 and compared between ( 1 ) the CT-screening group and the control group and , ( 2 ) the control group and each of the true-positive , false-positive and true-negative groups .


If confirmed in larger trials , emollient therapy from birth would be a simple and low-cost intervention that could reduce the global burden of allergic diseases .


Median follow-up was 17.2 years ( IQR 13.0-19 .0 ) .


PI3K/Akt inhibition eliminated the protective effects of exercise training and quercetin treatment .


The study aim was to determine the effect of age on CQ concentrations .


SP2 was the most cost-effective up to 39,800 / QALY .


After adjustment for cardiovascular risk factors and randomised treatment , annual incidence was 2.08 % , 2.10 % , 2.31 % and 2.96 % for participant groups defined by SBP reductions of 20 , 10-19 , 0-9 and < 0 mm Hg , respectively ( p = 0.0006 for trend ) .


Proportion of newborns needing endotracheal intubation .


This randomized , multicenter trial conducted from April 26 , 2012 , through April 9 , 2014 , in 8 countries consisted of 4 phases : 3-week screening phase , flexible-dose 17-week open-label transition phase , 12-week open-label maintenance phase , and open-ended double-blind ( DB ) phase .


Seventy-five liver transplant recipients were eligible , including 25 patients each in arm A , B and arm C.


The safety outcome ( all-cause mortality , occurrence of malignancy , or hospitalization due to infection ) was not significantly different between the groups ( relative risk , 1.46 ; 95 % confidence interval , 0.63-3 .38 ) , neither was all-cause mortality at 6 months with 5 % versus 6 % ( relative risk , 0.78 ; 95 % confidence interval , 0.22-2 .80 ) .


The results of these bioavailability studies indicate that the test formulation of losartan/hydrochlorothiazide 50 + 12.5 mg ( EPR0001 ) tablets is bioequivalent to marketed Preminent reference formulation in Asian Indian and Japanese volunteers , when administered under fasting conditions .


Endogenous pain modulation ( EPM ) is central to the processing of sensory information .


Despite depressive disorders being very common there has been little research to guide primary care physicians on the choice of treatment for patients with mild to moderate depression .


The accuracy of most CPCs in the diagnosis of AMI was low in women and men , with likelihood ratios close to 1 .


Patients aged 18 years or older with primary insomnia by DSM-IV-TR criteria were assigned using a computer-generated randomised allocation schedule to receive nightly suvorexant ( 40 mg for patients younger than 65 years , 30 mg for patients aged 65 years or older ) or placebo at a 2:1 ratio for 1 year with a subsequent 2-month randomised discontinuation phase in which patients on suvorexant either continued suvorexant or were abruptly switched to placebo while patients on placebo remained on placebo .


Following repeated administration , mean etamicastat AUC was 2 - to 3-fold greater in poor acetylators than in rapid acetylators .


Furthermore , in elderly patients , in the rivaroxaban group there was a trend to increase the principal safety outcome regardless of renal function .


We aimed to study the activity of LAP in HER2-amplified GC .


Continuing patients were randomized ( 2:2:1 ratio ) to alirocumab 75 mg self-administered via single 1 mL prefilled pen every 2 weeks or ezetimibe 10 mg/day or atorvastatin 20 mg/day ( statin rechallenge ) , for 24 weeks .


Sleep-related QoL was assessed using King 's Health Questionnaire Sleep/Energy domain .


Enrolled patients were randomized to either switching to LdT ( 600 mg/d orally ) plus ADV ( 10 mg/d orally ) ( LdT + ADV group ) or to continuation with LAM ( 100 mg/d orally ) plus ADV ( 10 mg/d orally ) ( LAM + ADV group ) , and were followed for 48 wk .


The rate of atherosclerosis progression was measured by B-mode ultrasonography as the increase in CIMT .


Since the introduction of breast-conserving treatment , various radiation doses after lumpectomy have been used .


Given the association between initial and 1-year weight loss , the first few months of treatment may be an opportune time to identify those who are unsuccessful and utilize rescue efforts .


Among the study variables , age , sex , administered dosage , history of previous GI complaints , and history of hyperemesis gravidarum in female patients were not statistically different among the groups ( p > 0.05 ) .


In the intent-to-treat analyses , topiramate neither improved treatment retention nor reduced cocaine and other substance use .


This prospective randomized trial aims to evaluate the surgical outcome of SSLS and CL appendectomy using CL equipment .


Effectiveness was compared statistically ( ANOVA/Tukey 's ) based on % area covered by deposited precipitate layer ( % DPL ) , % dye penetration inhibition ( % DPI ) and percentage of fully-open ( % FOT ) , partially-occluded ( % POT ) and completely-occluded ( % COT ) tubules in each block calculated relative to the number of tubules in their control blocks .


Two weeks following delivery , dyads were randomly assigned to the `` parenting '' or `` safety '' groups .


And the clinical efficacies of two groups were compared .


Students participated in a role-play practical facilitated either by clinicians , peer-teachers or non-clinical staff .


CT perfusion parameters before and after transarterial radioembolization for different response groups were compared .


A significant reduction in the primary endpoint without increased bleeding was observed in the EU-label cohort .


We assessed the impact of reamberin 1.5 % ( succinate-containing infusion solution ) on the level of metabolism and recovery after surgery in patients of main group ( n = 44 ) and control group ( n = 43 ) during different surgeries .


Urine cotinine-confirmed 7-day PPA at week 26 was 15.7 % ( n = 109 ) and 10.1 % ( n = 69 ) , respectively ; OR = 1.68 , 95 % CI 1.21-2 .33 ; p = 0.002 .


We assessed prevalence of tremor by questionnaire in 84 patients with CMT .


Main outcome measure was the change in the severity of OCD symptoms ( Yale-Brown Obsessive Compulsive Scale Self-Rating , Y-BOCS SR , and Obsessive-Compulsive Inventory-Revised , OCI-R ) .


The pharmacokinetics and tolerability of ticagrelor were broadly similar in Japanese and Caucasians , although exposure was slightly greater in Japanese volunteers .


Extreme hypo-fractionation induced a significant prostate swelling during treatment that was still present at the time of last treatment fraction .


We did a prespecified analysis of the ADRB2 polymorphisms Arg16Gly and Gln27Glu within the 1 year randomised , double-blind , double-dummy , parallel-group Prevention Of Exacerbations with Tiotropium in COPD ( POET-COPD ) trial , comparing the effects of treatment with tiotropium or salmeterol on exacerbations in 7376 patients with COPD .


From Jan 14 , 2011 , to Nov 14 , 2013 , 240 patients were assessed for eligibility and randomly assigned to treatment ( 120 in the cisplatin plus gemcitabine group and 120 in the paclitaxel plus gemcitabine group ) .


Depending on the extent of the outbreak , effectiveness of antibiotics and availability of vaccine , the full dose 0 , 28 or 0 , 14 , 28 schedules may have advantages .


A 10-day treatment may improve H. pylori eradication rate .


Better methods of risk stratification are required .


These data provide mechanistic evidence supporting the low intrinsic hypoglycaemic potential of albiglutide .


As part of a randomized trial , the first patients recruited in the intervention group were enrolled in a supervised exercise program of six week duration .


US and CT findings concurred in 67.5 % ( 27/40 ) of cases .


ClinicalTrials.gov Identifier : NCT01640782 .


The analysis included 1,137 patients .


Through 48 weeks , more than 90 % of patients given E/C/F / tenofovir alafenamide or E/C/F / tenofovir disoproxil fumarate had virological success .


Similarly , VPT increased by 16.5 % ( P = .021 ) in the WBV group and 23 % ( P = .078 ) in the LMV group immediately postintervention , but it did not increase in the control group .


There were no treatment-related serious adverse events ( SAEs ) , and the number of SAEs ( intervention 13.1 % [ 181/1 ,378 ] , control 12.7 % [ 174/1 ,374 ] , P = 0.712 ) and AEs ( intervention 10.5 % [ 144/1 ,378 ] , control 10.8 % [ 149/1 ,374 ] , P = 0.737 ) was similar .


The provision of audible breath sound/snoring replay permits more accurate quantification of snoring .


To assess the effect of the consumption of different types of protein ( whey protein , soy protein and egg white ) on a second meal postprandial glycaemia in normal weight and normoglycemic subjects .


Eligible nondiabetic subjects with T1-3 , N0-3 , M0 breast cancer who had completed surgery and ( neo ) adjuvant chemotherapy ( if given ) provided fasting plasma samples at random assignment and at six months .


For the control group , the average postoperative flatus time was ( 34 11 ) hours .


Parents received an introductory seminar with 2 sets of specially designed exercise for their overweight children .


Within Pretest 2 of the German National Cohort ( GNC ) we therefore investigated the acceptance and feasibility of extracting vaccination status from vaccination certificates provided by the participants of the study .


The initial positive changes may be the basis for obtaining better clinical results during long-term treatment .


Eligible adult patients had amyotrophic lateral sclerosis , a vital capacity of more than 60 % of that predicted for age and height , and symptom duration of less than 3 years .


Conditions did not differ significantly in the impact on manic symptoms or functional impairment .


The KT value obtained was greater with post-dilution OL-HDF [ 68 ( 8.1 ) compared to 64.9 ( 8.8 ) litres ] ( P = .009 ) when patients were dialysed at ST. This difference disappeared when dialysis was performed at ET .


A newly developed H-coil allows the stimulation of deeper brain regions .


It can be observed not only in terms of increased compensation claims but also costs due to absenteeism , loss of productivity at work and reduced psychological and physiological health and well-being .


Insertion was successful with one attempt in 35 cases each for the W and C groups .


Anchor - and distribution-based methods were used to identify an RD for the MSIS-29 .


Canagliflozin increased UGE dose-dependently ( 80-120 g/day with canagliflozin 100 mg ) , with increases maintained over the 14-day dosing period with each dose .


Pharmacokinetic parameters for both quetiapine and N-desalkyl quetiapine ( norquetiapine ) were determined .


A statistically significant improvement in nocturnal frequency was seen with tadalafil over placebo ; however , the treatment difference was small and not considered clinically meaningful .


The psychometric analysis supports the application of the self-regulation model to ageing perceptions , but also the existence of distinct `` physical decline '' and `` ongoing development '' dimensions of perceptions .


In a double-blinded study , patients with bilateral impacted mandibular third molars underwent surgical extractions , with one socket receiving PRF and the other one serving as a control .


In acute hypoxia , hypoxic training conferred no advantage on maximal oxygen uptake but tended to enhance time trial performance more than normoxic training ( 52 % vs 32 % , P = 0.09 ) .


Subjective ratings indicated deficits in up to 27 % of patients .


There were no differences in postoperative hemostasis procedures , transfusion and anesthesia duration .


Postoperative atrial fibrillation occurrence was monitored by biotelemetry .


Female Tibetan students show higher normal weight rate , but lower overweight and obesity rates , than male Tibetan students .


Five intervention patients ( 1.4 % ) experienced cardiovascular serious adverse events within 24 hours compared with none in the usual care group .


DADS and DAS were not detected in the urine samples at any time after garlic powder intake .


To evaluate the impact of remote ischemic preconditioning ( RIPC ) on clinical outcome , biological markers of myocardial injury , and its safety in patients undergoing on-pump coronary artery bypass grafting ( CABG ) .


Independent of randomization group , compared with no rejection , death-censored graft survival was significantly worse in 23 patients with acute rejection after randomization .


Patients ( n = 2757 ) were randomized to standard aromatase inhibitors ( AI ) alone ( group A ) or with EMs ( group B ) in a global , real-world setting .


UNICEF .


The clinical symptom scores , including diarrhea , abdominal distension and pain , were obviously reduced in two groups compared with those before the treatment ( all P < 0.05 ) .


Filter retrieval was planned at 3 months from placement .


No differences were seen at the hip or lumbar spine by dual-energy X-ray absorptiometry .


Patients were grouped into three categories according to the RT-ARD score ; 0-8 ( no RT-ARD ) , 9-23 ( minor RT-ARD ) , 24-45 ( major RT-ARD ) .


Participants in the referent group received standard care .


Propensity score matching was conducted with 26 parameters ( C-statics : 0.73 ) .


Older people ( N = 60 ) admitted to SSR .


In this phase 2 , multicentre , randomised , double-blind , parallel-group , placebo-controlled , dose-ranging study , we included Japanese patients with inadequately controlled type 2 diabetes despite diet and exercise treatment .


There was no difference between the 2 systems in terms of discrimination or adenoma detection .


Patients were followed for survival up to 12 years after completing baseline assessments .


Significantly more patients experienced side effects in the BOACT group compared to the BOTMO group ( 77.4 % vs 36.6 % , P < 0.01 ) .


The primary outcome measure is the rate of PTM until death or 12months ( whichever is sooner ) , as defined by the presence of a clinically palpable nodule of at least 1cm diameter felt within 7cm of the margins of the procedure site as confirmed by two assessors .


Of the 503 T2DM participants ( mean age , 62 years ) with successful baseline and 40-month brain MRI , 28 had at least one HA episode during the 40-month follow-up .


To evaluate the comparative cost-effectiveness of two strategies to promote work functioning among nurses by reducing symptoms of mental health complaints .


To compare the effects of alfaxalone and propofol on intraocular ( IOP ) pressure in the canine eye .


A total 430 children were included ( 215 matched pairs ) .


Mean age of patients was 59.64 3.84 years in group A and 60.56 4.12 years in group B ( p value = 0.92 ) .


These secondary analyses suggest that brief behavioral treatment of insomnia may be more efficacious in improving insomnia in participants without nocturia .


Application of NPPV for 102 patients was randomly observed in the conditions of a 2-hour spontaneous breathing trial ( SBT-2 ) and pulmonary infection control ( PIC ) window .


DIAMOS is composed of cognitive behavioral interventions aiming at the reduction of diabetes distress .


Patients examined with a 260-mAs low-dose were exposed to a statistically significantly lower dose ( 1.77 vs 2.33 mSv ; p < 0.01 ) .