Judul: The Effectiveness of Keji Beling (Strobilanthes crispus Blume)  Leaf Infusion as Antidiarrheal in Mice (Mus musculus)
Abstrak: Tanaman keji beling telah lama digunakan untuk pengobatan penyakit pada manusia, namun penelitian terkait manfaat tanaman keji beling sebagai antidiare masih sedikit. Tujuan penelitian ini adalah mengevaluasi secara ilmiah efek infusa daun keji beling sebagai antidiare dengan metode proteksi intestinal dan transit intestinal pada mencit. Penelitian ini menggunakan 36 ekor mencit yang dibagi menjadi enam kelompok terdiri dari kelompok kontrol negatif (Tween 80 [1%]), kontrol positif (suspensi loperamid HCl), dan empat kelompok perlakuan infusa daun keji beling dengan konsentrasi 12,5%, 25%, 50%, dan 100% yang diberikan secara oral. Parameter yang diamati yaitu frekuensi defekasi, konsistensi feses, dan rasio lintasan marker usus. Berdasarkan metode proteksi intestinal, infusa daun keji beling dengan konsentrasi 12,5%, 25%, dan 50% memiliki efek antidiare, sedangkan pada metode transit intestinal hanya infusa daun keji beling konsentrasi 50% yang memiliki efek antidiare. Berdasarkan kedua metode, infusa daun keji beling konsentrasi 50% menunjukkan efek antidiare yang paling efektif., Keji beling plant has long been used for the treatment of diseases in human, but research regarding the benefits of the keji beling plant as an antidiarrheal are still few. The purpose of this study was to evaluate scientifically the effect of keji beling leaf infusion as an antidiarrheal with intestinal protection and intestinal transit method in mice. This study used 36 mice which were divided into six groups consisting of a negative control group (Tween 80 [1%]), a positive control group (loperamide HCl suspension), and four groups of treatment with a keji beling leaf infusion concentration of 12,5%, 25%, 50%, and 100% given orally. The parameters observed were the frequency of defecation, the consistency of faeces, and the ratio of marker passages in the intestines of mice. Based on intestinal protection method, infusion of keji beling leaf with concentrations of 12.5%, 25%, and 50% has an antidiarrheal effect, while in the intestinal transit method only the infusion of keji beling leaf with concentration of 50% has an antidiarrheal effect. Based on the two methods, infusion of keji beling leaf at a concentration of 50% showed the most effective antidiarrheal effect.
Keyword: antidiarrhea, intestinal protection, intestinal transit, Strobilanthes crispus

Judul: Efektivitas Kombinasi Infusa Daun Keji Beling dan Daun Sembukan Sebagai Antidiare Pada Mencit
Abstrak: Diare merupakan satu di antara beberapa gangguan kesehatan yang sering terjadi pada hewan secara global dengan dampak kerugian ekonomi cukup besar. Pengobatan yang diberikan untuk mengatasi diare umumnya berasal dari bahan sintetik (farmasetik) yang dapat menimbulkan efek samping yang tidak diinginkan. Daun keji beling dan sembukan secara turun-temurun sudah digunakan sebagai pengobatan tradisional, namun belum ada penelitian farmakologis mengenai antidiare yang berasal dari kombinasi daun keji beling dan sembukan. Penelitian ini bertujuan menguji aktivitas serta mengetahui konsentrasi terbaik kombinasi infusa daun keji beling dan sembukan sebagai antidiare. Kelompok perlakuan terdiri atas kelompok kontrol negatif (suspensi Tween 80 [1%]), kontrol positif (suspensi loperamide HCl), dan kombinasi infusa (konsentrasi 12,5%, 25%, 50%, dan 100%). Metode yang digunakan adalah proteksi dan transit intestinal pada mencit. Hasil penelitian menunjukkan bahwa kombinasi infusa daun keji beling dan sembukan memiliki aktivitas antidiare yang bekerja dengan cara menurunkan frekuensi defekasi, memperbaiki konsistensi feses, dan dapat menekan motilitas usus. Kombinasi infusa daun keji beling dan sembukan dengan konsentrasi 50% memiliki aktifitas antidiare yang paling efektif., Diarrhea is one of several health problems that often occur in animals, globally with a large economic impact. Medications given to treat diarrhea generally come from synthetic (pharmaceutical) ingredients which can cause unwanted side effects. The leaves of keji beling and sembukan have been used for generations as traditional medicine, but there has been no pharmacological research on anti-diarrheal drugs derived from a combination of keji beling and sembukan leaves. This study aims to test the activity and find out the best concentration of the combination of keji beling and sembukan leaf infusion as an anti-diarrheal. The treatment group consisted of a negative control group (Tween 80 [1%] suspension), positive control (loperamide HCl suspension), and a combination of infusions (concentrations of 12.5%, 25%, 50%, and 100%). The method used is protection and intestinal transit in mice. The results showed that the combination of infusion of keji beling and sembukan leaves has an anti-diarrheal activity which works by reducing the frequency of defecation, improving stool consistency, and suppressing intestinal motility. The combination of infusion of keji beling and sembukan leaves with a concentration of 50% has the most effective antidiarrheal activity.
Keyword: diarrhea, intestinal protection, intestinal transit, keji beling, sembukan

Judul: Construction of Strongly Optimal Binary Linear Code with Minimum Distance 9 and 11
Abstrak: A binary linear code of length n over q F is a subspace of n q F . A code has three parameters that attached to it, namely length, dimension, and minimum distance. A code with length n, dimension k and minimum distance d is often called [n, k, d ]-code. Usually, when two parameters are given, then we want to find a code that has the best value for the last parameter. Based on Gilbert- Varshamov bound, if a [n, k, d ]-code exists and can not be expanded, we call it a strongly optimal code. In this paper, we construct strongly optimal code with minimum distance 9 and 11. In constructing the code, we created a theorem and algorithm based on Gilbert-Varshamov bound before we implement the algorithm to MAPLE programming language. Because of computational limitations, the program can only construct up to k = 10 for d = 9 and k = 12 for d = 11.
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