Judul: Gambaran histopatologi jaringan ateroma aorta potong beku dari kelinci New Zealand white (Oryctolagus curiculus) Hiperlipemik dengan dan tanpa antihiperlipidemia
Abstrak: The aim of the research is to investigate the histopathology of atheroma lesion within aorta wall from hyperlipemic rabbit (Oryctolagus cuniculus) with and without antihyperlipidemia drug treatment using Cryo-section method. The research use 12 New Zealand white rabbit (Oryctolagus cuniculuc;) devided into 3 groups, hyperlipemic rabbit group (H), hyperlipemic rabbit group with anti-hyperlipidemia drug treatment (HA) and control group (KN). The hyperlipemic condition of the animal was obtained by giving the rabbit 02g/day pure cholesterol for 3 months, and anti-hyperlipidemia drug of choice is statin dose 1.25glday for 2 month treatment. The examination of aorta wall revealed that the New Zealand white rabbit is responsive for the atherogenesis process, The atherogenesis observed inclllde lipid accumulation on the endothelial surface, lipid initiation in the intimal up to the medial layer of aorta wall and atheroma plaque formation. All the rabbits showed the athrogenesis process. The anti-hyperlipidemia drug could decrease the blood total cholesterol level and damaged the plaque structure. The cryo-section technique with Sudan Black staining could show lipid distribution on arterial wall and fragile atheroma lesion obviously.
Keyword: 

Judul: Lipid Peroxide Concentration in The Liver of Hyperlipidemic Rabbits Treated by Hypolipidemic Substance.
Abstrak: Degenerative disease has caused the highest mortality in the world. The disease may occur due to our life style which prefer fast food than traditional one and overeating resulted in hyperlipidemic. This condition will increase lipid peroxidation caused by free radicals in the body such as in the liver. The objective of this research is to determine the influence of hypolipidemic substance on lipid peroxide in the liver of hyperlipidemic rabbits. Twenty four male New Zealand White rabbits were divided into four group: group I (normal), group II (Hyperlipidemic), group III (mixture of Jati Belanda), and group IV (lovastatin). Lipid peroxide concentration was measured by TBA (thiobarbiturit acid) assay that measure malondyaldehida (MDA) as product of lipid peroxidation using spectrophotometer at λ = 532 nm (Yagi et al 1994). The result of the research showed that feeding rabbits with chow contains 0.5% cholesterol and 5% of palm oil caused hyperlipidemic. Lipid peroxide concentration of rabbit’s liver in group II increased two times compared with group I. Group III and IV had lower lipid peroxide concentration of rabbit’s liver compared with group II which is 58.83% and 49.06%. This data showed that Jati Belanda leave mixture and lovastatin decreased lipid peroxidation in the liver.
Keyword: 

Judul: Peranan Pemimpin Informal dalam Menggerakan Partisipasi Masyarakat  untuk Pembangunan Desa
Abstrak: Pendekatan pembangunan yang banyak diterima para ahli adalah pendekatan dari bawah ke atas (bottom up) yang berarti bahwa dalam pembangunan diperlukan keikutsertaan rakyat. Keikutsertaan tidak hanya pada tahap merencanakan pembangunan, akan tetapi juga ikut dalam melaksanakan, bahkan sampai pada menilai hasil-hasil pembangunan (Cohen dan Uphoe 1977; Dusseldorp, 1981; Slamet, 1993). Agar rakyat yang berhimpun dalam kelompok-kelompok dapat ikut serta, mereka harus memiliki sejumlah kualifikasi yang diperlukan untuk itu.
Keyword: