Judul: Physicochemical property and inhibition activity of Indonesian Honeys toward β-Secrtease Enzymes
Abstrak: Indonesia memiliki berbagai jenis madu lokal dengan karakteristik dan kualitas yang beragam. Madu-madu lokal tersebut bisa mengandung senyawa bioaktif yang bisa menghambat aktivitas enzim β-sekretase. Penelitian ini bertujuan untuk mengevaluasi karakteristik fisikokimia beberapa jenis madu lokal Indonesia dan menguji kemampuannya dalam menghambat aktivitas enzim β-sekretase. Tiga jenis madu lokal yang digunakan dalam penelitian ini adalah madu rambutan, kelengkeng dan multiflora. Kadar air dan viskositas ketiga madu tersebut secara statistic berbeda (P < 0.05). Kadar air madu rambutan (20,75%) lebih tinggi dibandingkan dengan kadar air madu kelengkeng (19,27%) dan madu multiflora (19,18%). Sementara itu, madu multiflora memiliki tingkat kekentalan paling tinggi (24,00 pascal second) dibandingkan dengan madu rambutan (18,33 pascal second) dan madu kelengkeng (19,67 pascal second). Di sisi lain, tingkat keasaman ketiga madu tersebut tidak berbeda secara signifikan dengan rentang 31,48 – 45,16 mL NaOH. Analisis penghambatan enzim β-sekretase dengan uji fluorometri menunjukan bahwa aktivitas enzim tersebut secara signifikan lebih rendah dengan penambahan salah satu madu lokal tersebut (P<0.05). Madu multiflora memiliki aktivitas penghambatan lebih tinggi (243,63 RFU) dibandingkan dengan madu rambutan (394,45 RFU) dan kelengkeng (401,17). Meskipin demikian, daya hambat tersebut masih lebih rendah dibandingkan dengan inhibitor komersial (132,82 RFU). Penelitian ini menunjukan ketiga madu tersebut sudah memenuhi standar SNI dan menunjukan bahwa ketiga madu tersebut mampu menghambat enzim β- sekretase., Indonesia is rich with the local honeys with different characteristics and qualities. The local honeys may contain various bioactive compounds exhibiting inhibitory properties against β-secretase enzyme. This enzyme is known to be the culprit behinds various neurodegenartive diseases, which is found to be one of publich health issue in Indonesia. This study aims to evaluate the physicochemical properties of several Indonesian local honeys and investigate their inhibitory properties against β-secretase. To address, three local honeys were used, including rambutan, kelengkeng and raw multifloral honey. Water content and viscosity of these honeys were found to be statistically different (P<0.05). Rambutan honey has the highest water content (20.75%) than the kelengkeng (19.27%) and raw multifloral (19.18%). Meanwhile, the raw multifloral honey was found to have the highest viscosity (24.00 pascal second) compared to rambutan (18.33 pascal second) and kelengkeng (19.67 pascal second). On the other hand, the acidity of those honey were statistically comparable (P>0.05), with the values ranging from 31.48 to 45.16 mL NaOH. Interestingly, inhibitory assay against β-secretase enzyme showed that the three madu were able to reduce the enzymatic activity (P<0.05). The raw multifloral honey exhibited highest inhibiton activity (243,63 RFU) than the rambutan (394,45 RFU) or the kelengkeng (401,17). Nevertheless, these activities were remarkably lower than the inhibition activity of the commercially available inhibitor for β-secretase enzyme (132.82 RFU). Altogether, this study showed that three honeys met the SNI standard and showed that the three honeys were able to inhibit the -secretase enzyme.
Keyword: madu, β-sekretase, fisikokimia madu, beta amyloid

Judul: Physicochemical Properties and Antioxidant Activities Multiflora Honey from Kerinci Regency Jambi
Abstrak: Madu merupakan cairan kental yang dihasilkan oleh lebah madu (Apis sp.) dari nektar bunga atau bagian tanaman lainnya. Penelitian ini bertujuan menganalisis sifat fisikokimia dan aktivitas antioksidan madu multiflora (madu hutan Apis dorsata) dan (madu budidaya Apis cerana) dari Kabupaten Kerinci, Jambi. Sifat fisikokimia yang dianalisis adalah warna, pH, viskositas, kadar air, kadar abu, kadar gula, kadar HMF, keasaman, dan aktivitas antioksidan. Hasil penelitian menunjukkan bahwa madu hutan berwarna Light Amber, sedangkan madu budidaya berwarna Extra Light Amber. Kualitas madu hutan yang memenuhi SNI 01-3545-2013 adalah pH, viskositas, kadar air, kadar gula, kadar HMF, dan keasaman, namun memiliki kadar abu yang melebihi batas SNI 01- 3545-2013. Madu budidaya memiliki pH, kadar gula, dan kadar HMF yang memenuhi SNI 01-3545-2013, namun memiliki viskositas, kadar air, kadar abu, dan keasaman yang belum memenuhi SNI 01-3545-2013. Madu hutan dan madu budidaya memiliki kapasitas antioksidan masing-masing sebesar 16,74 mgVCE/g dan 16,60 mgVCE/g, sedangkan aktivitas antioksidannya berturut-turut adalah 63,80% dan 63,28%, Honey is a thick liquid produced by honey bees (Apis sp.) from flower nectar or other parts of plants. This study aims to examine the physicochemical properties and antioxidant activities of multifloral honey (Apis dorsata forest honey) and (Apis cerana cultivated honey) from Kerinci, Jambi. The analysed physicochemical properties were colour, pH, viscosity, water content, ash content, sugar content, HMF content, acidity and antioxidant activity. The results showed that forest honey has Light Amber colour while cultivated honey has Extra Light Amber colour. The quality of forest honey that meet SNI 01-3545-2013 is pH, viscosity, water content, ash content, sugar content, HMF content, and acidity, however the ash content exceeded SNI 01-3545-2013. Cultivated honey has pH, sugar content, and HMF content is which meet the SNI 01-3545-2013, however the viscosity, water content, ash content, and acidity was that didn't meet SNI 01- 3545-2013. Forest honey and cultivated honey have antioxidant capacities of 16,74 mgVCE/g and 16,60 mgVCE/g, meanwhile the antioxidant activity were 63,80% and 63,28%.
Keyword: antioxidant activities, cultivated honey, forest honey, multifloral honey, physicochemical properties

Judul: Implementation of Spatio-Temporal Change Query in Relational Database.
Abstrak: Geographic object changes in various views. Object changes are recorded using a model of static storage. No historical connection between old version data and new version data has been built. For that, a storage model of spatio-temporal queries that can analyze spatio-temporal changes has been developed. The object changes the geometry are grouped according to the taxonomy of Spatio-Temporal Pattern Change. This research has been able to apply the query patterns change including born, expand, merge, contract, split, normal and die. This query based on geometric (area) changes. The implementation of spatio-temporal change queries represents an object changes continuously with easy, change detection is done by comparing two versions of data. Keyword: spatio-temporal change query, spatio-temporal change pattern.
Keyword: