Judul: Analisis nilai guna ekonomi dan dampak penambangan pasir di Kecamatan Tamansari Kabupaten Bogor
Abstrak: Barang tambang merupakan sumberdaya alam yang tidak dapat diperbaharui. Jumlah penduduk yang semakin tinggi mengakibatkan semakin meningkatnya kebutuhan manusia akan sandang, pangan, dan papan. Kegiatan pemanfaatan sumberdaya alam dalam sektor pertambangan merupakan salah satu usaha guna memenuhi kebutuhan tersebut. Stok lahan yang tetap, mengharuskan pemanfaatan untuk pertambangan akan terbatas jumlahnya. Interaksi antara aktivitas ekonomi manusia dan sumberdaya alam yang tidak seimbang menimbulkan masalah lingkungan.
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Judul: Dampak aktivitas pertambangan bahan galian golongan c terhadap kondisi kehidupan masyarakat desa (analisis sosio-ekonomi dan sosio-ekologi masyarakat Desa Cipinang, Kecamatan Rumpin, Kabupaten Bogor, Jawa Barat)
Abstrak: Mining activities is a natural resource mining dredging activities of contained in the soil. This mining activities in its implementation will give positive and negative impact on sosio-economic and sosio-ecological aspect for the local community. The purpose of this study is 1) to explain the sosio-economic impacts of mining activities and 2) to explain the sosio-ecological impacts of mining activities. This research metode uses a quantitative approach supported by the use of qualitative approach. Primary data obtained from the interviews and questionnaires, while secondary data obtained from the documentation and study of literature. The data generated using of cross tabulation and frequency tables and descriptive analysis. The selection of respondents using of cluster sampling techniques to select two different village is Kampung Joglo and Kampung Gunung Cabe. The choice of location is based on mining the large number of industrial plants to see an impact on the agricultural sector. The result of this research showed that in general, in Kampung Joglo and Kampung Gunung Cabe, mining activities gives a negative impacts on socio-economic and sosio-ecological aspects. On sosio-economic aspect are seen in the declining level of the employment in agriculture due to the limited area of agricultural land owned by the local community. Meanwhile, the level of non-agricultural employment opportunities have increased in line with the opening of employment opportunities in the mining sector. The occurens conflicts between local communities with the company caused by the changes of environmental conditions. On sosio-ecological aspect is the occurens changes of the air, a disturbance on the condition of water resources, noise pollution is caused by blasting activities and mineral transport trucks. In addition, still many community members who suffers from respiratory tract such as shortness of breath, caugh, colds and diarrhea.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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