Judul: Coastline Change Using Landsat Satellite Imagery on the North Coast of Java, Banten
Abstrak: Perubahan garis pantai yang disebabkan abrasi dan akresi akan menunjukkan kecenderungan perubahan garis pantai yang terkikis atau bertambah. Deteksi perubahan garis pantai menggunakan teknologi penginderaan jauh merupakan salah satu metode observasi yang dapat dilakukan secara multi temporal. Tujuan penelitian untuk mengetahui perubahan garis pantai dengan menggunakan citra satelit di Pantai Utara Jawa, Banten dengan metode Digital Shoreline Analysis System (DSAS). Proses analisis data meliputi empat tahapan, yaitu pengolahan citra awal, ekstraksi garis pantai, perhitungan perubahan garis pantai, dan pengolahan data pendukung. Kecepatan angin dominan berasal dari arah barat yang berkisar antara 3,60-5,70 m/s. Pergerakan arus di daerah kajian menunjukkan pergerakan arus bergerak dari timur menuju barat. Nilai tinggi gelombang mencapai 0,21 m dengan periode gelombang 0,01-3,09 m/s. Hasil perhitungan nilai bilangan formzhal menghasilkan nilai tipe pasang surut sebesar 4,05 yang termasuk ke dalam tipe pasang surut tunggal. Abrasi terbesar terjadi di Kecamatan Mauk dengan kemunduran garis pantai sebesar 928,55 m, sedangkan akresi terbesar terjadi di Kecamatan Kemiri dengan penambahan garis pantai sebesar 380,99 m. Kata Kunci : Abrasi, Akresi, DSAS, Ekstraksi, Penginderaan Jauh
Keyword: Abrasion, Accretion, DSAS, Extraction, Remote Sensing

Judul: Deteksi Perubahan Garis Pantai di Kabupaten Indramayu, Jawa Barat
Abstrak: Pesisir Kabupaten Indramayu memiliki kerentanan pesisir yang tinggi akibat interaksi darat dan laut sehingga mudah mengalami perubahan secara fisik seperti perubahan garis pantai. Deteksi perubahan garis pantai menggunakan teknologi penginderaan jauh merupakan salah satu metode observasi yang dapat dilakukan secara multi temporal. Penelitian ini bertujuan untuk memetakan dan mengetahui perubahan garis pantai di Kabupaten Indramayu, Jawa Barat menggunakan citra Sentinel-2A pada tahun 2016 dan 2022 dengan metode Digital Shoreline Analysis System (DSAS). Hasil dari metode DSAS didapatkan nilai perubahan garis pantai yang memiliki nilai positif dan negatif. Nilai positif berarti pantai mengalami akresi sedangkan nilai negatif pantai mengalami abrasi. Laju abrasi tertinggi terjadi di Desa Paben llir, sementara itu akresi tertinggi terjadi di Desa Krangkeng. Faktor–faktor terjadinya abrasi ialah gelombang, arus, pembukaan lahan seperti tambak sehingga terjadi kemunduran garis pantai. Faktor–faktor terjadinya akresi adalah proses sedimentasi oleh aliran sungai. Kata Kunci: Abrasi, Akresi, DSAS, Garis Pantai., The coast of Indramayu Regency had high coastal vulnerability due to the interaction of land and sea so it easily experiences physical changes such as changes in coastlines. Detection of coastline changes using remote sensing technology is an observation method that can be carried out multi-temporally. This research aims to map and determine coastline changes in Indramayu Regency, West Java using Sentinel-2A imagery in 2016 and 2022 using the Digital Shoreline Analysis System (DSAS) method. The results of the DSAS method show coastline change values with positive and negative values. A positive value means the beach is experiencing accretion while a negative value is that the beach is experiencing abrasion. The highest abrasion rate occurred in Paben Illir Village, meanwhile, the highest accretion occurred in Krangkeng Village. The factors for abrasion were waves, currents, and the conversion of mangroves into ponds resulting in a decline in the coastline. The factors that cause accretion were sedimentation processed by river flows. Keywords: Abrasion, Accretion, DSAS, Shoreline
Keyword: Abrasi, Akresi, DSAS, Garis Pantai

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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