Judul: Slum Settlement Area Arrengement Planning in Babakan Lio, Kelurahan Balumbang Jaya, Kecamatan Bogor Barat, Kota Bogor
Abstrak: Peningkatan jumlah penduduk dan perkembangan perkotaan menjadi faktor utama yang mendorong pertumbuhan pemukiman. Pertumbuhan cepat di daerah perkotaan berakibat pada peningkatan tempat tinggal yang tidak memadai, mulai dari sarana, prasarana hingga utilitasnya. Keterbatasan pemerintah dalam mengantisipasi kondisi seperti ini akhirnya menciptakan kawasan kumuh perkotaan. Daerah Babakan Lio termasuk salah satu kawasan permukiman yang memiliki masalah kekumuhan di Kelurahan Balumbang Jaya. Masalah kekumuhan yang dapat ditemukan di Babakan Lio di antaranya kepadatan bangunan, kualitas jalanan yang kurang baik, masalah saluran drainase, dan lain sebagainya. Penelitian ini bertujuan merencanakan penataan kawasan permukiman Babakan Lio yang berkelanjutan beserta sarana, prasarana dan utilitasnya. Penelitian ini dilakukan dengan meninjau dan mengidentifikasi kondisi eksisting permukiman. Perencanaan site plan penataan, bangunan hunian, sarana, dan prasana dibuat menggunakan standar acuan SNI 03-1733-2004 dan standar lainnya. Perencanaan sarana dan prasarana meliputi peremajaan jalan dan drainase, tempat pembuangan sementara, dan fasilitas umum seperti masjid, toko, lahan parkir, serta ruang terbuka hijau (RTH). Peremajaan kawasan babakan lio ini menghasilkan angka KDB sebesar 37,7% dari seluruh luas kawasan., The increase in population and urban development are the main factors driving residential growth. Rapid growth in urban areas results in an increase in inadequate housing, from facilities, infrastructure to utilities. The government's limitations in anticipating conditions like this ultimately create urban slum areas. The Babakan Lio area is one of the residential areas that has a slum problem in Balumbang Jaya Village. Slum problems that can be found in Babakan Lio include building density, poor quality roads, drainage problems, and so on. This research aims to plan a sustainable arrangement of the Babakan Lio residential area along with its facilities, infrastructure and utilities. This research was carried out by reviewing and identifying the conditions of existing settlements. Planning for site planning, residential buildings, facilities and infrastructure is made using the reference standard SNI 03-1733-2004 and other standards. Planning for facilities and infrastructure includes rejuvenation of roads and drainage, temporary dump sites, and public facilities such as mosques, shops, parking lots and green open spaces (RTH). The rejuvenation of the Babakan Lio area resulted in a KDB figure of 37,7% of the entire area.
Keyword: Area Arrangement, Residential Buildings, Infrastructure

Judul: Arrangement Strategy of Slum Settlement In Balumbang Jaya Sub-District, West Bogor District, Bogor City
Abstrak: Kelurahan Balumbang Jaya memiliki permukiman kumuh menurut surat keputusan wali kota Bogor Nomor 653.45 – 282 tahun 2019. Penelitian ini dilakukan di Kelurahan Balumbang Jaya, Kecamatan Bogor Barat, Kota Bogor dengan tujuan mengidentifikasi tingkat kekumuhan, merencanakan konsep penataan yang sesuai, dan mengukur prioritas pengendalian peningkatan kualitas sarana-prasarana lingkungan. Metode penelitian dilakukan dengan identifikasi analisis multikriteria untuk tingkat kekumuhan dan deskriptif kuantitatif untuk konsep penataan dan urutan prioritas. Parameter yang diidentifikasi berupa kondisi bangunan gedung, jalan lingkungan, penyediaan air bersih, drainase lingkungan, pengelolaan air limbah, pengelolaan persampahan, dan proteksi kebakaran. Diketahui kondisi eksisting permukiman kumuh terletak di RW 003, 004, 011, dan 012. Rencana peningkatan kualitas sarana-prasarana lingkungan diarahkan pada kegiatan peningkatan pelayanan PDAM, pembangunan tangki septik komunal, desain ulang tempat pembuangan sampah sementara, dan pembangunan hidran kebakaran. Urutan prioritas dari bobot karakteristik kumuh terbesar yaitu RW 003, RW 011, RW 004, dan RW 012.
Keyword: Balumbang Jaya, Permukiman Kumuh, Sarana dan Prasarana Lingkungan, Tingkat Kekumuhan

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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