Judul: Potensi Bioaktif Minyak Gaharu Budi Daya (Aquilaria malaccensis dan A. microcarpa) dan Decaying Log (Gyrinops).
Abstrak: Minyak gaharu sangat bermanfaat bagi kesehatan karena mengandung senyawa bioaktif, seperti alkaloid, saponin, steroid, terpenoid, tanin, flavonoid, fenolik, dan asam lemak. Pada penelitian ini dilakukan pemisahan minyak gaharu A. malaccensis (M1), A. microcarpa (M2), dan Gyrinops (M3) dengan metode distilasi uap air kemudian menguji potensinya terhadap aktivitas antijamur, antioksidan, dan sitotoksisitas terhadap sel kanker payudara (MCF-7) dengan metode 3-[4,5-dimetiltiazol-2-il]2,5-difeniltetrazolium bromida (MTT). Pemisahan minyak menghasilkan rendemen 0.079-0.084%. Aktivitas antioksidan tertinggi dimiliki M1 dengan nilai %inhibisi 16.25%. Sitotoksisitas M1 terhadap sel kanker MCF-7 memiliki %inhibisi tertinggi dengan nilai 15.19% pada konsentrasi 600 μg/mL. Minyak gaharu berpotensi sebagai antijamur dengan penghambatan tertinggi terhadap pertumbuhan Fusarium solani sebesar 58.73% yang dimiliki oleh M3. Identifikasi senyawa menggunakan kromatografi gas dengan perhitungan indeks retensi kovat menunjukkan adanya 70 senyawa yang terbagi menjadi 3 golongan, yaitu monoterpena, seskuiterpena, dan asam lemak.
Keyword: antijamur, antioksidan, kromatografi gas, minyak gaharu, sitotoksisitass

Judul: Sitotoksisitas Fraksi Teraktif Kemedangan Pohon Penghasil Gaharu Jenis Aquilaria microcarpa pada Sel Kanker Payudara MCF-7.
Abstrak: Gaharu mengandung senyawa metabolit sekunder dan secara tradisional dimanfaatkan sebagai obat antikanker. Penelitian ini bertujuan menentukan sitotoksisitas fraksi kemendangan pohon penghasil gaharu jenis Aquilaria microcarpa. Sampel dimaserasi menggunakan pelarut etil asetat untuk mengambil senyawa semipolar. Ekstrak difraksionasi menggunakan kromatografi kolom menghasilkan 15 fraksi. Penapisan menggunakan uji letalitas larva udang menunjukkan fraksi 6, 11, 12, dan 13 bersifat toksik. Sitotoksisitas ekstrak kasar etil asetat, 2 fraksi dengan LC50 terendah, yaitu fraksi 11 dan 13, serta doksorubisin sebagai kontrol positif diujikan pada sel lestari MCF-7. Dihasilkan nilai IC50 berturut-turut 0.81, 1.07, 3.44, dan 0.49 μg/mL. Berdasarkan hasil ini, kedua fraksi yang diuji memiliki aktivitas sitotoksik dan berpotensi antikanker. Kedua fraksi masih berupa campuran senyawa, maka diperlukan fraksionasi lebih lanjut untuk mendapatkan senyawa murni yang lebih aktif sebagai antikanker daripada doksorubisin.
Keyword: antikanker, fraksionasi, kemedangan, sitotoksisitas

Judul: Thermal Characteristics and Dynamics of Tropical Cyclone over Western North Pacific Ocean: A Case Study of Typhoon Songda (Chedeng) 2011
Abstrak: The frequent occasion of Tropical Cyclone (TC) over Western North Pacific (WNP) Ocean lies from 10˚N to 26˚N and 121˚E to 170˚E. Sources of TC development come from warm ocean temperature where latent heat is released during condensation processes and subsequently concentrated in the boundary layer. Relative humidity at 850-700 hPa is responsible to produce the most intense storm. Meanwhile, weak vertical wind shear between 850-200 hPa is one of the dynamical factors that lead to the development of TC. Pressure level of 850-200 hPa is chosen to minimize the thermodynamic effect in the lower troposphere. Typhoon Songda (Chedeng in the Philippines) or TSC lasted from May 18th to 30th, 2011 and strengthened into powerful Super Typhoon stage between May 24th and 27th. Long curving track and the exhibition of all sequences of TC life cycle, TSC is then considered as an ideal case of TC. The objective of the study with case of TSC is to investigate the role of thermal characteristics and dynamics on TC intensity. The research is carried out by using Advanced Research of Weather Research and Forecasting model (WRF ARW model) version 3.3. Two domains are employed in the model. The first domain situate from 02˚N to 40˚N and 118˚E to 149˚E and cover spatial resolution () of 33.1 km. The second domain situate from 09˚N to 27˚N and 119˚E to 132˚E with of 11 km. Timestep of the model () is 120 seconds. The model is supported by the following physical parameterization, i.e., Yonsei University Scheme (YSU) in the boundary layer, Kain-Fritsch scheme (KF) in the cumulus, and WRF Single-Moment 3-class scheme in the microphysics. Initial meteorological condition prior to the formation of the cyclone is generated using WRF ARW standard-release model. Sensitivity of the model output is obtained from a selected single-parameter change scenarios, namely, 10 % to 20 % decrease and increase of wind shear initial data at 850-200 hPa, and by 10 % to 20 % decrease of relative humidity initial data at 850-700 hPa. The result showed that the negative correlations between wind shear and intensity are found in wind shear scenarios. Wind shears of 10 ms-1 which lead to strengthening of the wind intensity in the early period of Typhoon development are found in wind shear scenarios. The effect of wind shear changes on wind intensity is statistically significant in the 20 % wind shear scenarios. During mature stage, weak wind intensity occurred when wind shear increase as given in the WRF standard-release and the 20 % decreasing scenario. Different situation is found in the 20 % increasing scenario where wind shear tend to weak and lead to strong wind intensity at this stage. Meanwhile, the reduction of moisture supply at 850-700 hPa resulting from 20 % decreasing relative humidity play a major role in the weakening of wind intensity and reduces mechanical energy of the cycle process as much as 300 J kg-1.
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