Judul: Perencanaan Penataan Kawasan Permukiman Kumuh di Babakan  Tengah, Desa Babakan, Kecamatan Dramaga, Kabupaten Bogor
Abstrak: Babakan Tengah merupakan kawasan yang terletak dekat dengan Kampus IPB Dramaga. Meskipun terletak di sekitar lingkungan kampus yang dinamis, keberadaan permukiman kumuh di Babakan Tengah tetap menjadi potensi masalah yang perlu diperhatikan. Masalah kekumuhan yang mengindikasikan wilayah Babakan Tengah merupakan permukiman kumuh adalah padatnya bangunan, jalan lingkungan yang rusak, ruang terbuka hijau yang minim, serta beberapa masalah lainnya. Penelitian ini bertujuan untuk merencanakan penataan kawasan kumuh di Babakan Tengah menjadi permukiman yang layak dan berkelanjutan. Perencanaan dilakukan dengan mengidentifikasi aspek struktur peniliaian kekumuhan serta pembuatan site plan yang mengacu pada PermenPUPR Nomor 14 Tahun 2018, RTRW Kabupaten Bogor serta SNI yang berlaku. Pembuatan perumahan, bangunan vertikal, TPS, dan taman serta peremajaan jalan dan saluran drainase merupakan hasil dari upaya penanganan masalah kekumuhan di Babakan Tengah. Hasil perencanaan penataan menunjukkan peningkatan kualitas kawasan yang ditunjukkan dengan kenaikan luasan jaringan jalan menjadi 20,3%, drainase menjadi 7,3%, dan RTH menjadi 32,8% serta menurunnya luas total bangunan menjadi 24,6%., Babakan Tengah, a neighborhood situated near the IPB Dramaga Campus. However, despite its proximity to the vibrant campus environment, the presence of slum areas in Babakan Tengah remains a potential issue that demands attention. The overcrowding of buildings, deteriorating neighborhood roads, the scarcity of green open spaces, and other issues all point to the fact that Babakan Tengah is a slum areas. This research aims to plan the revitalization of the slum areas in Babakan Tengah into a decent and sustainable living space. The planning process involves identifying the structural aspects of slum assessment and creating a site plan based on PermenPUPR No. 14/2018, the Bogor Regency Spatial Planning Master Plan (RTRW), and applicable SNI standards. The construction of housing, vertical buildings, TPS, and parks, along with the rejuvenation of roads and drainage channels, represent the efforts to address the slum issues in Babakan Tengah. The results of the revitalization planning show an improvement in the quality of the area, which is indicated by the increase in the area of the road network by 20.3%, drainage by 7.3%, and green space by 32.8%. Additionally, there is a decrease in the total area of buildings by 24.6%.
Keyword: Babakan Tengah, Slum areas, Revitalization

Judul: Slum Settlement Area Arrengement Planning in Babakan Lio, Kelurahan Balumbang Jaya, Kecamatan Bogor Barat, Kota Bogor
Abstrak: Peningkatan jumlah penduduk dan perkembangan perkotaan menjadi faktor utama yang mendorong pertumbuhan pemukiman. Pertumbuhan cepat di daerah perkotaan berakibat pada peningkatan tempat tinggal yang tidak memadai, mulai dari sarana, prasarana hingga utilitasnya. Keterbatasan pemerintah dalam mengantisipasi kondisi seperti ini akhirnya menciptakan kawasan kumuh perkotaan. Daerah Babakan Lio termasuk salah satu kawasan permukiman yang memiliki masalah kekumuhan di Kelurahan Balumbang Jaya. Masalah kekumuhan yang dapat ditemukan di Babakan Lio di antaranya kepadatan bangunan, kualitas jalanan yang kurang baik, masalah saluran drainase, dan lain sebagainya. Penelitian ini bertujuan merencanakan penataan kawasan permukiman Babakan Lio yang berkelanjutan beserta sarana, prasarana dan utilitasnya. Penelitian ini dilakukan dengan meninjau dan mengidentifikasi kondisi eksisting permukiman. Perencanaan site plan penataan, bangunan hunian, sarana, dan prasana dibuat menggunakan standar acuan SNI 03-1733-2004 dan standar lainnya. Perencanaan sarana dan prasarana meliputi peremajaan jalan dan drainase, tempat pembuangan sementara, dan fasilitas umum seperti masjid, toko, lahan parkir, serta ruang terbuka hijau (RTH). Peremajaan kawasan babakan lio ini menghasilkan angka KDB sebesar 37,7% dari seluruh luas kawasan., The increase in population and urban development are the main factors driving residential growth. Rapid growth in urban areas results in an increase in inadequate housing, from facilities, infrastructure to utilities. The government's limitations in anticipating conditions like this ultimately create urban slum areas. The Babakan Lio area is one of the residential areas that has a slum problem in Balumbang Jaya Village. Slum problems that can be found in Babakan Lio include building density, poor quality roads, drainage problems, and so on. This research aims to plan a sustainable arrangement of the Babakan Lio residential area along with its facilities, infrastructure and utilities. This research was carried out by reviewing and identifying the conditions of existing settlements. Planning for site planning, residential buildings, facilities and infrastructure is made using the reference standard SNI 03-1733-2004 and other standards. Planning for facilities and infrastructure includes rejuvenation of roads and drainage, temporary dump sites, and public facilities such as mosques, shops, parking lots and green open spaces (RTH). The rejuvenation of the Babakan Lio area resulted in a KDB figure of 37,7% of the entire area.
Keyword: Area Arrangement, Residential Buildings, Infrastructure

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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