Judul: Analyzing The Proteins of Indonesia Varian Chikungunya Virus for Antiviral Design from Bioactive Compounds of Indonesian Herbs
Abstrak: Chikungunya merupakan penyakit menular yang disebabkan oleh virus chikungunya (CHIKV) dan belum ditemukan obatnya. Penelitian ini bertujuan mengidentifikasi protein CHIKV yang berpotensi sebagai target obat serta memprediksi senyawa bioaktif dari tanaman herbal Indonesia sebagai kandidat obat anti-CHIKV. Sekuens protein CHIKV diperoleh dari publikasi terbaru mengenai endemik chikungunya pada tahun 2015. Selanjutnya, protein-protein tersebut dianalisis tingkat paraloginya satu sama lain, homologinya terhadap proteom manusia dan bakteri usus, serta interaksinya dengan protein manusia. Hasil beberapa analisis tersebut menunjukkan nsP2 merupakan protein paling potensial untuk dijadikan sebagai target obat. Kandidat obat dipilih dari ligan herbal yang telah dipublikasikan strukturnya sebanyak 5550 senyawa. Hasil penapisan virtual menunjukkan lima senyawa katekin yang berpotensi dikembangkan sebagai inhibitor nsP2 yaitu epigalokatekin 3-O-(3-O-metil)-galat (EGCMG), epigalokatekin 3-O-galat (EGCG), epikatekin 3-O-galat (ECG), epigalokatekin 3-O-kafeat (EGCC), dan galokatekin 3’-O-galat (GCG). Kelima senyawa tersebut memiliki afinitas pengikatan pada rentang -8,0 sampai -7,5 kcal/mol (AutoDock Vina) dan -9,19 sampai -9,88 kcal/mol (AutoDock 4)., Chikungunya is an infectious disease caused by CHIKV, and the drug for the disease has not been identified yet. This research aimed to identify the essential proteins of CHIKV as drug targets and predict bioactive compounds from Indonesian herbal plants as the drug candidates for CHIKV. The essential proteins of CHIKV were obtained from the recently published studies which were the data from the endemic happened in 2015. These proteins were analyzed by the level of paralogy within each other, the homology against proteomes of human and gut microbiome, and their interaction with the human proteins. The investigation shows that nsP2 was the most potent protein for the drug targets. In addition, the drug candidates were virtually screened from 5550 of the herbal compounds in which the structures had been published. Five compounds potentially to be investigated for the next study were EGCMG, EGCG, ECG, EGCC and GCG. The binding affinities are in range -8.0 to -7.5 kcal/mol (AutoDock Vina) and -9.19 to -9.88 kcal/mol (AutoDock 4).
Keyword: chikungunya virus, docking, epigallocatechin, nsP2, virtual screening

Judul: Virtual Screening of Potent Chikungunya Virus Envelope Protein Inhibitor from Ligands of Indonesian Herbs Using in Silico Approaches.
Abstrak: Chikungunya adalah penyakit menular yang disebabkan oleh virus chikungunya (CHIKV) melalui vektor nyamuk dan mulai meluas sejak adanya perubahan iklim selama satu dekade terakhir. Penyakit ini tidak menyebabkan kematian, tapi dapat bersifat kronis. Hingga saat ini, belum tersedia obat yang dapat menghambat CHIKV secara spesifik. Penelitian ini bertujuan menapiskan kandidat obat dari ligan herbal tanaman Indonesia yang berpotensi menghambat protein selubung CHIKV. Penapisan dilakukan secara virtual menggunakan AutoDock Vina. Dari hasil penapisan 5588 senyawa herbal dipilih lima ligan dengan energi afinitas ikatan paling tinggi adalah (E,Z)-Terrestribisamide (-8,0 kcal/mol), grevirobstol A (-8,0 kcal/mol), dehydropipernonaline (-7,9 kcal/mol), 7,8-Dihydroxy-4'-methoxyisoflavone (-7,8 kcal/mol), dan gingerenone A (-7,8 kcal/mol). Nilai energi afinitas tersebut lebih tinggi dibandingkan ligan pembanding, 1-[(1-Benzylpiperidin-4-yl)amino]-3-phenoxypropan-2-ol (-6,6 kcal/mol) yang telah teruji menghambat proliferasi CHIKV., Chikungunya is an infectious disease caused by the chikungunya virus (CHIKV) transmitted by mosquitoes, and began to expand since climate change over the past decade. The disease doesn’t cause death, but can be chronic. Thus far, there are no available drugs that can specifically inhibit CHIKV. This study was aimed to screen drug ligand candidates from Indonesian herbs that can potentially inhibit CHIKV envelope protein. The virtual screening approach was done using AutoDock Vina. From the screening of 5588 compounds, five best compounds with highest binding affinity energy are selected, namely (E,Z)- terrestribisamide (-8,0 kcal/mol), grevirobstol A (-8,0 kcal/mol), dehydropipernonaline (-7,9 kcal/mol), 7,8-Dihydroxy-4'-methoxyisoflavone (-7,8 kcal/mol), and gingerenone A (-7,8 kcal/mol). The binding affinity energy of selected ligands are higher than the comparative ligand, 1-[(1-Benzylpiperidin-4- yl)amino]-3-phenoxypropan-2-ol (-6,6 kcal/mol), which has demonstrated inhibition activity against CHIKV proliferation.
Keyword: chikungunya, envelope protein, virtual screening

Judul: Dampak Perceraian dan Hubungan Sosial terhadap Kesejahteraan Psikologis Ibu sebagai Orang Tua Tunggal
Abstrak: Family with a single mothers who came from divorced, often bring the impact such as problem or change on a single mothers well-being. The aim of this research to indentify characteristics of single mother and relations with psychological well-being and social relations, and also analyze impact divorce on psychological well-being and social relations. Descriptive analysis, regression, and Pearson correlation was used in this study. The respondents were sixty single mother who come from the length divorced more than six month. The result showed that compare with present condition, psychological well-being, impact of divorce and social relation respondent are more significant lower than the first six month after divorce. There was relationship between age of present and divorce, family’s income, and size of family with level of depression, social support, and economic impact. Based on regression analysis we found there was negative effect of impact of divorce to psychological well-being at the first six month after divorce and the present. Other wise, we found there was not significant effect of divorce to social relationship.
Keyword: economic impact, level of depression, social support