Judul: Effect Of Bee Venom To Cell Death And Spatial Memory In Mice (Mus Musculus)
Abstrak: Bee venom has been used as an alternative medicine as well as prevention of various diseases. It contains complex compounds and some of its content act as allergen and inflammation agents. It is expected to cause cell death in brain and to affect spatial memory. The objective of this study was to determine dose of bee venom that causes neuronal cell death in dentate gyrus, amygdala, and cerebral cortex as well as analyze the alteration of mice behaviour, particularly spatial memory. Fifteen male mice of Deutche Denken Yoken (DDY) were divided into control and treatment groups. Bee venom was injected six times for two weeks intraperitoneally with doses 1.88 mg/kg (P1), 3.76 mg/kg (P2), 5.6 mg/kg (P3), and 7.48 mg/kg (P4), respectively. Brain slices were made by paraffin method in 5 μm coronal section and stained by haematoxylin eosin. The Y maze method was used for behaviour assay. Parameters observed were the number of neuronal cell death in hippocampus, amygdala, and cerebral cortex, and percentage of alteration mice behaviour in Y maze. This study used complete randomized design method which consists of five treatments and three repetitions. Data was analyzed using one-way (ANOVA) in SPSS. The results showed differences in the mean of neuronal cells death in dentate gyrus, amygdala, and cerebral cortex. Mean of neuronal cells death varied in each treatment compared to control. The highest mean of dead neuron in dentate gyrus, amygdala, cortex upper layer (2-4), and cortex deep layer (5-6) was 1510 cell/mm2, 1754 cell/mm2, 1415 cell/mm2, and 1168 cell/mm2 while the lowest mean was 220 cell/mm2, 326 cell/mm2, 420 cell/mm2, and 365 cell/mm2, respectively. The highest mean of alteration after 24 h bee venom injection was 74.57 % and the lowest was 61.07 %. The highest mean of alteration after 72 h bee venom injection was 76.03 % and the lowest was 57.50 %. Analysis of variance (ANOVA) showed that effect of bee venom was significantly different in the number of neuronal cell death in dentate gyrus and amygdala, but no significant effect in cerebral cortex as well as mice behaviour. The Duncan’s Multiple Range Test (DMRT) results showed that P4 significantly different to neuronal cells death in dentate gyrus and amygdala compared to other treatments. Based on the study, bee venom induced neurotoxic effect because it caused neuronal cell death in dentate gyrus, amygdala, and cerebral cortex and tend to affect spatial memory.
Keyword: bee venom, neuronal cell death, mice behaviour

Judul: Effectiveness of Forest Honey Towards Analgesic and Stamina in Mice (Mus musculus Albinus)
Abstrak: Secara empiris, madu telah digunakan oleh masyarakat untuk memperbaiki kualitas kesehatan manusia. Penelitian ini bertujuan untuk mengetahui efek madu terhadap analgesik dan stimulator stamina. Pengujian analgesik dilakukan dengan metode tail immersion test, sedangkan stimulator stamina menggunakan metode ketahanan berenang. Penelitian ini menggunakan 20 ekor mencit yang diberi sari buah jeruk nipis dengan berbagai dosis, yaitu 0, 1, 2, dan 4 g/kg BB, dengankelompok 0 menjadikelompokkontrol. Setiap kelompok perlakuan terdiriatas 5 ekor mencit. Data yang diperoleh dianalisis menggunakan analisis varian (ANOVA) yang dilanjutkan dengan uji Tukey. Hasil penelitian ini menunjukkan bahwa pemberian madu pada mencit percobaan dosis 1 g/kg BB memiliki efektivitas terbaik sebagai analgesik dan stimulator stamina. Kesimpulan dari penelitian ini adalah bahwa madu memiliki potensi untuk dimanfaatkan sebagai sediaan sebagai analgesik dan stimulator stamina alami. Kata kunci: alami, analgesik, madu, mencit, stamina, Empirically, honey has been used by the community to improve the quality of human wellbeing. This study aims to determine the effect of honey on analgesics and stamina stimulators. Analgesic testing was done by the tail immersion test method, while stamina stimulatorwas tested by swimming endurance method. This study comprised of 20 mice that were given lime juice with various doses, namely 0, 1, 2, and 4 g / kg BW, with group 0 being the control group. Each treatment group consisted of 5 mice. The data obtained was analyzed using analysis of variance (ANOVA) followed by Tukey test. The results of this study indicated that the administration of honey in mice trial dose of 1 g / kg BW had the best effectiveness as an analgesic and stamina stimulator. It can be concluded that honey has the potential to be used as an analgesic and natural stamina stimulator.
Keyword: natural, analgesic, honey, mice, stamina

Judul: Peranan Pesantren dalam Pembangunan Pedesaan
Abstrak: Pesantren (pondok atau pondok pesantren) adalah suatu lembaga pendidikan keagamaan Islam yang pada umumnya tumbuh di kalangan masyarakat pedesaan. Pertumbuhannya merupakan hasil refleksi pimpinan pesantren dan masyarakat terhadap kebutuhan masyarakat sekitar. Disamping sebagai lembaga pendidikan keagamaan, diharapkan pesantren dapat berperan sebagai lembaga sosial kemasyarakatan yang dapat membantu pemerintah dalam menyebar luaskan inovasi pembangunan kepada masyarakat, dan menggerakkan masyarakat agar berperan serta dalam pembangunan.
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