Judul: Studi Kasus Echocardiography Normal pada Anjing Siberian Husky Dewasa
Abstrak: Echocardiography digunakan secara umum pada bidang kedokteran hewan untuk mengevaluasi struktur dan fungsi jantung pada anjing. Studi kasus ini bertujuan untuk mengevaluasi hasil echocardiography normal pada ras Siberian Husky. Pengukuran echocardiography diperoleh dengan teknik standar, yaitu B-Mode, M-Mode, dan Color Flow Doppler menggunakan Acclarix AX3 Vet USG dan probe microconvex dengan frekuensi 5-9 MHz. Pemeriksaan dilakukan pada posisi hewan right parasternal dan left apical. Hasil menunjukkan bahwa Siberian Husky berusia enam tahun dengan berat 32 kg dalam studi kasus ini memiliki jantung yang normal. Hasil perbandingan echocardiography M-Mode dengan nilai rentang referensi normal untuk anjing dengan ukuran, peran, dan berat yang serupa menunjukkan left ventricular internal dimension in diastole (LVIDd) di bawah rentang normal, sementara left ventricular posterior wall in diastole (LVWPd) dan left ventricular posterior wall in systole (LVPWs) lebih tinggi. Hasil ini menunjukkan perlunya interval referensi spesifik berdasarkan ras. Studi kasus ini menjelaskan hubungan antara nilai echocardiography normal dengan fungsi jantung anjing yang digambarkan melalui nilai ejection fraction (EF) 66,04% dan fractional shortening (FS) 35,52%. Hasil echocardiography normal pada Siberian Husky ini dapat dibandingkan dengan interval referensi ras serupa yang merupakan working dogs, sehingga menjadi nilai referensi yang penting untuk penelitian lanjut., Echocardiography is commonly used in veterinary medicine to assess cardiac structure and function in dogs. This case study evaluates normal echocardiography results in an adult Siberian Husky. Standard techniques, including B-Mode, M-Mode, and Color Flow Doppler, were employed using the Acclarix AX3 Vet USG and a microconvex probe (5-9 MHz). Examinations were conducted in the right parasternal and left apical positions. Results indicate that the six-year-old, 32 kg Siberian Husky in this study exhibited a normal heart. When comparing M-Mode echocardiography with the normal range for dogs of similar size, role, and weight, left ventricular internal dimension in diastole (LVIDd) was below the normal range, while left ventricular posterior wall in diastole (LVWPd) and left ventricular posterior wall in systole (LVPWs) were higher. These findings highlight the necessity for breed-specific reference intervals. This case study emphasizes the correlation between the normal echocardiography interpretation and canine cardiac function, as depicted by the value of ejection fraction (EF) 66,04% and fractional shortening (FS) 35,52%. The echocardiography results of the Siberian Husky in the study are comparable to reference interval values of similar breeds that are working dogs, making them valuable as reference values for future studies
Keyword: echocardiography, jantung, nilai referensi, Siberian Husky, echocardiography, heart, reference values, Siberian Husky

Judul: A Case Study of Hypertrophy Cardiomyopathy, Sinus Tachycardia, and Endocardiosis of Labrador Retriever Dog
Abstrak: Penyakit jantung sering menyerang anjing. Studi kasus ini bertujuan mengetahui peran pemeriksaan penunjang seperti elektrokardiografi (EKG), radiografi dan ultrasonografi (USG) dalam menegakkan diagnosis hipertrofi kardiomiopati (HCM), sinus takikardia, dan endokardiosis pada anjing Labrador retriever. Anamnesis yang diperoleh ialah anjing mengalami batuk intermiten. Pemeriksaan EKG tidak menunjukkan kelainan pada gelombang P, Q, R, S, dan T, namun terdeteksi adanya peningkatan detak jantung hingga 200 beats per minute. Temuan radiografi tampilan ventrodorsal ialah kondisi kardiomegali. Pemeriksaan USG brightness mode (B-mode) menunjukkan adanya penebalan pada muskulus papillaris dan endokadium. Pemeriksaan USG motion mode (M-mode) menunjukkan adanya peningkatan denyut jantung dan ketebalan left ventricle posterior wall-diastole (LVPWd), serta penurunan ejection time (ET), end diastolic volume (EDV), end systolic volume (ESV), dan stroke volume (SV). Pemeriksaan USG color flow Doppler (CFD) tidak menunjukkan adanya kelainan katup atrioventrikular dan katup semilunaris. Berdasarkan hasil pemeriksaan, hewan didiagnosis mengalami sinus takikardia, endokardiosis, dan HCM., Heart disease often affects dogs. This case study aims to determine the role of supporting examinations such as electrocardiography (ECG), radiography and ultrasonography (USG) to diagnose hypertrophy cardiomyopathy (HCM), sinus tachycardia, and endocardiosis in Labrador retrievers. The history obtained was that the dog had an intermittent cough. The electrocardiography did not showed any abnormalities in the P, Q, R, S, and T waves, but an increase in heart rate was detected up to 200 beats per minute. The radiographic finding on the ventrodorsal view was cardiomegaly. The Brightness mode (B-mode) ultrasound examination showed an increase in thickness of the papillary muscles and endocardium. Motion mode (M-mode) ultrasound examination showed an increase in heart rate and thickness of the left ventricle posterior wall-diastole (LVPWd), and decreased ejection time (ET), end diastolic volume (EDV), end systolic volume (ESV), and stroke volume (SV). Color flow Doppler (CFD) ultrasound examination did not show any abnormalities of the atrioventricular valve and semilunar valve. Based on the examination results mention above, the animal was diagnosed as/suffered from sinus tachycardia, endocardiosis, and HCM.
Keyword: electrocardiography, heart disease, Labrador retriever, radiography, ultrasonography

Judul: Sintesis Monobenzil Krisin dari Floroglusinol melalui Zat Antara Kalkon Pinosembrin Sebagai Prekursor Krisin
Abstrak: In this experiment, monobenzyl chrysin (7-benzyloxy5-hydroxyflavone) was synthesized from phloroglucinol as its starting material through oxidative cyclization route of pinocembrin chalcone. The synthesis was started with acetylation of phloroglucinol and benzylation of phloroacetophenone using 2 equivalents of benzyl bromide for 24 hours. The yield of those two steps were 70% and 21%, respectively. The condensation of 4’,6’-benzyloxy-2’- hydroxyacetophenone obtained with benzaldehyde produced a benzyl-protected chalcone which is then cyclisized oxidatively with 1 equivalent of I2 in dimethyl sulfoxide. About 9% of the product of this reaction was a monobenzyl chrysin according to characterization using proton nuclear magnetic resonance spectrum. The overall yield of this product was 1% with respect to phloroglucinol. The optimization of benzylation time of reaction and amount of added I2 should be studied further in order to increase the yield before the benzyl deprotection process conducted
Keyword: Bogor Agricultural University (IPB), flavonoids, flavones, chrysin, chalcone