Judul: Aktivitas Antioksidan Zat Ekstraktif Daun Mangium (Acacia mangiumWilld) Berdasar Uji secara In Vitro dan In Vivo.
Abstrak: Tujuan penelitian ini adalah menentukan rendemen dari ekstraksi daun mangium dengan pelarut air dan etanol, menganalisis kandungan total fenol, dan menetapkan aktivitas antioksidan secara in vitro pada ekstrak yang dihasilkan. Berdasar nilai rendemen dan aktivitas antioksidan tertinggi dipilih ekstrak paling prospektif kemudian diuji aktivitas antioksidan secara in vivo. Ekstraksi dilakukan menggunakan metode perebusan air dan sokletasi dengan etanol 30, 70, dan 100%. Aktivitas antioksidan in vitro diuji dengan metode 1,1-difenil-2-pikrilhidrazil (DPPH) dan secara in vivo dengan mengukur kadar malondialdehida (MDA) serum darah mencit. Rendemen ekstrak daun mangium tertinggi yaitu ekstrak etanol 30% diikuti ekstrak air, etanol 70, dan 100%. Aktivitas antioksidan yang dihasilkan dari keempat ekstrak tergolong sangat kuat. Aktivitas antioksidan ekstrak daun mangium etanol 30% tidak berbeda nyata dengan etanol 70% dan vitamin C. Ekstrak etanol 30% daun mangium dengan dosis 0.867 mg/kg/bb mencit/hari selama 7 hari mampu menurunkan kadar MDA serum dari 0.229±0.031 menjadi 0.090±0.055 μmol.
Keyword: difenil-2-pikrilhidrazil (DPPH), aktivitas antioksidan, ekstrak daun mangium, malondialdehida (MDA), mencit

Judul: Aktivitas Antidiabetes Ekstrak Kulit Mangium (Acacia mangium Willd.) Melalui Uji Penghambatan Enzim α-Glukosidase Secara In Vitro
Abstrak: Mangium (Acacia mangium Willd.) bark extract is categorized as active in inhibiting the activity of α-glucosidase enzyme by having IC50 ≤ 100 μg/mL. The purposes of this research are to determine mangium bark extract yield, determining its antidiabetic activity using in vitro α-glucosidase enzyme inhibition test, and analyze chemical components of the most active extract as α-glucosidase enzyme inhibitor. Extraction was conducted using boiling method with water and soxletation using various concentration of ethanol. Extraction of mangium using water, 30, 70, and 100% ethanol yielded 14.14, 11.72, 8.03, and 14.06% respectively. All extratcts are categorized as active in inhibiting the activity of α-glucosidase. Mangium bark extract with highest antidiabetic activity is ethanol 30% extract (IC50= 29.36 μg/mL), followed by 70% ethanol extract (IC50= 33.90 μg/mL), water extract (IC50= 35.14 μg/mL), and 100% ethanol extract (IC50= 35.49 μg/mL). Chemical component analysis results show that 30% ethanol extract contains dominant compound from phenolic group and alkaloids which inhibiting the activity of α-glucosidase enzyme.
Keyword: alkaloids., flavanoids, α-glucosidase, antidiabetic, mangium bark

Judul: Implementation of Spatio-Temporal Change Query in Relational Database.
Abstrak: Geographic object changes in various views. Object changes are recorded using a model of static storage. No historical connection between old version data and new version data has been built. For that, a storage model of spatio-temporal queries that can analyze spatio-temporal changes has been developed. The object changes the geometry are grouped according to the taxonomy of Spatio-Temporal Pattern Change. This research has been able to apply the query patterns change including born, expand, merge, contract, split, normal and die. This query based on geometric (area) changes. The implementation of spatio-temporal change queries represents an object changes continuously with easy, change detection is done by comparing two versions of data. Keyword: spatio-temporal change query, spatio-temporal change pattern.
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