Judul: Potensi Senyawa pada Biji Mahoni Berdaun Lebar (Swietenia macrophylla) sebagai Antipenuaan dengan Metode Penambatan Molekul
Abstrak: Munculnya flek kecokelatan dan keriput dapat menjadi tanda penuaan yang dapat meningkatkan risiko kanker. Senyawa pada biji mahoni berdaun lebar (Swietenia macrophylla) mengandung banyak senyawa dan diketahui memiliki aktivitas antikanker. Tujuan penelitian ini ialah menentukan senyawa pada biji tumbuhan tersebut yang berpotensi sebagai antipenuaan dengan menganalisis interaksi penambatan molekulnya pada enzim MMP-1 (matrix metalloproteinase), NEP (neprilysin), PPO3 (polyphenol oxidase), dan sebagai pendukung untuk mencari senyawa antikanker. Dua senyawa yang berpotensi sebagai inhibitor kuat terhadap enzim MMP-1 dan PPO3, ialah β-sitostenon dan 3β-hidroksistigmast-5- en-7-on yang merupakan golongan steroid, serta germakrena A dan germakrena D yang merupakan golongan terpenoid. Hanya senyawa 3β-hidroksistigmast-5-en-7- on yang berpotensi sebagai inhibitor kuat terhadap enzim NEP. Semua senyawa yang berpotensi sebagai inhibitor kuat memenuhi aturan Lipinski. Hanya senyawa yang berikatan dengan enzim PPO3 yang memiliki aktivitas yang lebih baik dari ligan alaminya berdasarkan nilai ΔG dan Binding Site Similarity (BSS).
Keyword: NEP, antipenuaan, MMP-1, NEP, penambatan molekul, PPO3

Judul: Bioaktivitas Biji Mahoni Berdaun Lebar (Swietenia macrophylla) sebagai Antikanker
Abstrak: There are three species of mahogany in Indonesia, namely small-leaf mahogany (Swietenia mahogany), broad-leaf mahogany (Swietenia macrophylla), and Swietenia sp. This study aimed to study the toxicity of bioactive compounds in fractions of ethyl acetate extract from broad-leaf mahogany seeds, which is potencial as anticancer, by using brine shrimp lethality test. The seeds were ground into powder and air-dried. The powder was then soxhletized with nhexane. The residue was macerated in 96% ethanol. The ethanol extract was evaporated and then extracted by using liquid-liquid extraction with 1:1 ethyl acetate-water. The ethyl acetate extract yield was 5.7% (w/w). The ethyl acetate extract was further fractionated by using column chromatography with gradien elution with chloroform and ethyl acetate. Four fractions were obtained with fraction 1 (Rf = 0.95 in 1:1 chloroform-ethyl acetate eluent) was the most active fraction with LC50 of 35.46 ppm and 12% (w/w) yield. This result showed that fraction 1 was potencial as anticancer. Phytochemical test of fraction 1 gave positive results for alkaloids, saponins, steroids, triterpenoids, and tannins.
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Judul: Pengembangan Model Quality of Experience untuk Televisi IPTV secara Empiris
Abstrak: Quality of Experience is closely related to expectations, customer experience and subjective perception of the performance of multimedia communications applications. Quality of Service is limited to the size of the network quality. The initial step in conducting the study is to prepare the IPTV network infrastructure consisting of a central station (headend), local transmission (core network) and a public transmission (access network). The next step is to do the Quality of Service measurement by flowing through IPTV network infrastructure a video format H.264 with a bit rate ranging from 1000 to 8000 kbps. Each node of the network is recording video packet data network (packet loss, delay and jitter). After that, map Quality of Service to Quality of Experience value using the ITU - T G1070. Transmission measurements at the central station (headend) show that the small values of QoS. Packet loss values lower than 0.10%, the value is lower than 32ms delay, and jitter values lower than 5ms. Video QoE value (VQ) ranged between 4 (Good). Stable QoE ensure good network performance. For transmission measurements on the local (core network), with a bit rate of ≥ 2000 kbps, shows that packet loss value is small (≤ 0.10%) and video QoE values ranged between 4 (Good). Average delay of RTP is approximately 60 ms and average jitter of RTP is 16.5 ms giving effect to the choppy video QoE. As for the TCP, it is relatively better because of the small value of QoS. Value of packet loss is approximately 0.0%, average delay is 5 ms and average jitter is 5.2 ms. Fluctuations QoE describe poor network performance to support IPTV services. For the measurement of the transmission to the public (access network) shows that the value of small packet loss (≤ 0.10%), the value of the RTP delay is around 60ms and jitter values of the RTP is 7.2ms. Video QoE value stable range between 4 (Good). Just as the headend, network performance has provided a good guarantee for IPTV services.
Keyword: Quality of Service, Quality of Experience, Mean Opinion Score, IPTV, video streaming, ITU-T G.1070.