Judul: Fungsi Hati Mencit pada Uji Toksisitas Subkronis Ekstrak Air Kulit Batang Mahoni (Swietenia macrophylla King)
Abstrak: Mahogany’s bark is industrial waste that can potentially be developed as herbal medicines. This research was performed to study the extract’s subchronic toxicity in the liver. Fourty mice consist of 20 males and 20 females were divided into 4 groups: normal, dosage 1 (D1), dosage 2 (D2), and dosage 3 (D3), each consisting of 5 males and 5 females. Normal group was administered with aquadest, whereas D1, D2, and D3 groups were orally gavaged with mahogany’s bark aqueous extract at concentration of 21, 200, and 400 mg/Kg BW for 56 days. Biochemical and histopathological parameters were observed at the end of experimental period. There were no difference in body weight, food intake, and liver enzymes. Range of ALT and AST activities were consecutively between 54.20±15.09 to 83.00±44.98 U/L and 83.80±21.73 to 164.33±99.28 U/L, and these values were normal. There was no toxic effect of mahogany’s bark aqueous extract to the liver, moreover according to histopathological examination the extract tended to protect female hepatocytes from nonspesific degeneration.
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Judul: Peroksidasi Lipid pada Tikus Hiperkolesterolemia selama Pemberian Ekstrak Kulit Batang Mahoni (Swietenia macrophylla)
Abstrak: Mahogany’s bark is known as wood industrial waste that contains potential secondary metabolites. However, its potency as an antioxidant, especially in rats which are subjected to hypercholesterolemic treatment, has not been carried out. The aim of this study was to test the effect of mahogany’s water extract consumption on the concentration of lipid peroxides in hypercholesterolemic rats. Thirty five male rats were divided into 5 groups (n=7) namely normal group fed with standard rat chow, hypercholesterolemic group (HK) fed with cholesterol chow (1,5%) and PTU (0,5 mg/KgBW), lovastatin group (HK+lovastatin 0,2857 mg/KgBW), E1 group (HK+ mahogany’s extract 4,2 mg/KgBW), and E2 group (HK+mahogany’s extract 21 mg/KgBW). Experiments were carried out for 8 consecutive weeks. The concentration of lipid peroxides in blood were measured with thiobarbituric acid assay at week 0, 2, 4, 6, and 8 using spectrophotometer. Cholesterol chow (0.86%) and PTU increased the lipid peroxides concentration of HK group by 20.92% compared to the normal group (3.380±0.436 nmol/mL). However, it is not statistically significant (p=0.239). The lipid peroxides concentration in E1 and E2 weren’t increased and relatively similar to normal group at concentration of 2.353±0.196 nmol/mL, 2.786±0.256 nmol/mL, and 2.673±0.279 nmol/mL, respectively. Although it is not statistically significant, both doses of extracts tend to prevent the lipid peroxidation in the rat’s blood.
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Judul: Query Expansion based on Bilingual Dictionary Using Conditional Probability
Abstrak: Query expansion is a technique that can be used to bridge vocabulary gaps between queries and documents in the collection. With query expansion, user will be helped to formulate queries well so that user will optimize the search result. In this study, the expansion term was resulted from the translation of bilingual dictionary. Subsequently, several terms of expansion were elected based on the closeness of its relationship with the original query. This research showed that conditional probability can be used to select expansion term in bilingual translation method query expansion. The result of 1000 documents was more than 97% relevan document can be retrieved by this system. The more expansion term used, the larger number relevan document was retrieved.
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