Judul: Infeksi alami virus rabies pada anjing: studi morfopatologi dan imunohistokimia
Abstrak: Rabies is a zoonotic disease that remains a big problem in public health sector in Indonesia. The pathomorphological and antigen distribution of street rabies virus infection of the dogs brain from endemic area in Indonesia need for further investigation. The aim of this study was to describe macroscopical, histopathological and antigen distribution of rabid dogs which is infected with rabies virus naturally. Fourteen brains of stray rabid dogs from Disease Investigation Centre Bukittinggi area were used as samples. Conformatory diagnosed based on direct fluorescence antibody technique test. Hyperemic meningeal blood vessels were consistently found in all samples, sometimes associated with multiple ptechie and cerebral edema. Histopathological changes showed mild non-suppuratif meningoencephalitis with perivascullar cuffing surrounded by lymphocyte cells, associated with gliosis. Negri bodies were found in neuron cytoplasms in all samples mainly localized in pyramidal cells of cornua ammons of hippocampus and cerebral cortex, while neuronal degeneration and necrosis were mild. Viral antigens localized in perikaryon extending along the dendrites and axon and mostly localized on pyramidal cells of hippocampus, talamus and frontal lobes of cerebral cortex. Rabies antigen were also detected in epithelial cells of mucogenic acini of mandibulary glands and mildly in granular of striated duct of luminal parotidal glands. This study suggested that frontal lobes of cerebral cortex and mandibulary glands could be used as samples for rabies test in laboratory besides hippocampus.
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Judul: Rabies Pada Hewan dan Pencegahannya di Indonesia
Abstrak: Rabies adalah penyakit menular yang akut dari susun- an syaraf pusat disebabkan oleh virus rabies yang dapat menyerang hewan berdarah panas (Hardjosworo, 1977). Rabies menyebabkan bahaya dan kerugian yang besar, sehingga memerlukan usaha pencegahan timbulnya penyakit tersebut. Pencegahan yang baik dan berkesinambungan akan mendapatkan harapan terbebasnya suatu wilayah terhadap penyakit rabies. Virus rabies dapat ditemukan pada jaringan syaraf dan sekresi kelenjar saliva hewan penderita (Belschner, 1974). Rabies yang ada di alam ditularkan oleh carnivora lewat gigitan. Semua hewan berdarah panas peka terhadap infeksi rabies (Tierkel, 1964). Menurut Keep (1982), Gejala klinis dari penyakit rabies dapat dibagi dalam tiga stadium atau fase yaitu stadium prodormal, stadium exitasi dan stadium paralitik. Dari ketiga fase ini, setelah melampaui fase prodormal akan didapatkan dua bentuk gejala, yaitu bentuk ganas (furious rabies) dan bentuk diam/dungu (dumb rabies). Diagnosa rabies memerlukan pemeriksaan riwayat hewan, tanda-tanda klinis, gambaran anatomis dan histo- phatologis serta pemeriksaan dari bahan/ specimen secara laboratorium. Pencegahan penyakit rabies pada hewan meliputi tindakan atau usaha untuk mencegah timbulnya penyakit rabies di suatu daerah, misalnya methode internal yang dilakukan terhadap vektor dan reservoir, dan usaha untuk mencegah meluasnya penyakit rabies dari suatu daerah ke daerah lain, misalnya dengan methode external yang dilakukan terhadap hewan-hewan yang berasal dari luar pembatasan….
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Judul: Metrik Einstein (Anti-) Self-Dual Berdimensi Empat dengan Metode Cartan
Abstrak: Gravitational field equation can be formulated in differential forms (differential geometry), which describes gravity as a manifestation of the curvature of space-time. Curvature of space-time is characterized by a metric that satisfies the gravitational field equation. With differential forms it can be formulated the (anti-) self-dual Einstein equation, which is a modification of the Cartan structure in (anti-) self-dual basis. Calculation of (anti-) self-dual metric with (anti-) self-dual Einstein equation is simpler than the calculation using Christoffel symbols.
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