Judul: Lipid Profiles and UCP-1 Expression in Cynomolgus Monkey with Atherogenic Risk AfterNicotine Intervention
Abstrak: Pola makan dengan tinggi kalori tanpa disertai dengan pengaturan keseimbangan energi antarakalori yang dikonsumsi dan kalori yang dikeluarkan merupakan penyebab dasarkelebihan berat badan yang mengarah ke obesitas. Kondisi ini sudah menjadi masalah global terutama di negara-negara berkembang dan di negara-negara maju olehkarena memiliki berbagai faktor resiko terhadap sindrom metabolik yang berkaitan dengan penyakit jantung koroner (PJK), diabetes melitus, dan hipertensi. Kelebihan berat badan pada sindrom metabolik dengan resiko tinggi aterosklerosis (atherogenetic process) diidentifikasi melalui adanya peningkatan indeks bobot badan (body mass index; BMI), lingkar pinggang atau rasio lingkar pinggang dan pinggul. Jaringan adipos dikenal sebagai tempat penyimpanan triglserida (TG), dan sebagai jaringan endokrin dinamik yang mengsekresikan free fatty acid (FAA) dan berbagai protein seperti adiponectin dan adipokin. Adapun profi lipid yang penting untuk mendiagnosis hiperlipoproteinemia yang mencakup ~lipidemia meliputi peubah kolesterol totai trigliserida, LDL-kolesterol dan HDL-kolesterol. Jaringan adipose diketahui pula sebagai organ endokrinaktif yang dapat mengsekresikan berbagai adipokin dan salah satunya adiponektin berperan dalam metabolisme lipid dan karbohidrat dalam sirkulasi darah dan berpotensi dalam sindrom metabolik., Obesityis an abnormal accumulation of body fat with increased risk of coroner heart disease atherosclerosis, indicated by hyperlipoproteinemia. There are many treatments to prevent metabolic syndrome related to obesity, particularly with atherosclerosis risk. The aims of this study were to obtain information of metabolic changes through lipid profile and body weight also to evaluate UCP-1 expression post nicotine intervention on cynomolgus monkey with atherogenic risk. Fifteen animals were divided into three groups, given isocaloric diets containing 1) beef tallow (as diet A); 2) beeftallow and egg yolk (as Diet B) and other primary materials, and 3) commercial monkey chow diet (as a control or as Diet C). These diets were given for one year to develop obesity, then continued for three months by additing nicotine in their diet at a dose of at least 0. 75 mg I kg body weight every 12 hours. Body weight and lipid profile were analyzed every months and brown adipose tissue was taken at necropsy for evaluating UCP-1 expression by using antibody fluoresence technique. This study used a complete randomized design (ANOV A) to analyzes body weight and lipid profile. There were significantly increased in total plasma cholesterolconcentration (p<0.01), especially for diet type B and triglyceride concentration was not significantly increased (p>0.01). Followed by significantly increased HDL and LDL level, however there was decreased in body weight. Evaluation of UCP expression in this study showed expression of UCP-1 in each diet group A, B and C. Group B showed to have higher expression of UCP-1 than the other groups.
Keyword: obesity, nicotine, hyperlipoprotenimia, UCP-1, cynomolgus monkey

Judul: Profil Bobot Badan, Indeks Massa Tubuh dan Glukosa Darah Monyet Ekor Panjang (Macaca fascicularis) yang Diberi Pakan Tinggi Energi dan Nikotin Cair
Abstrak: Nicotine with specific dose has been reported to have an affect to decreased appetite on rodents. Therefore, the objective of this study was to determine the effect of nicotine on body weight, body mass index and blood glucose levels of cynomolgus monkey (Macaca fascicularis) fed high energy diet given for three months. Ten adult males cynomolgus monkeys were randomly divided into two groups. The first group fed with main ingredient from beef tallow and the second group with commercial monkey chow. In both diets, nicotine liquid were added with final dosage consumed by monkeys of at least 0,75 mg/kg body weight. The design used in this study was complete randomized design in time. Data collected was analyzed to find correlation between time and treatment. Measurement was performed monthly on body weight, body mass index and blood glucose levels. Results showed that weight loss was not significant (P>0,05), however BMI and blood glucose level was decreased significantly in the first group (P<0,05). The conclusion of this study, nicotine intervention given for three months in adult male cynomolgus monkeys with high energy diet from beef tallow reduced blood glucose level and body mass index but not its body weigh
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Judul: Rancang Bangun Mekanisme Penggetar Untuk Bajak Subsoil Getar Dengan Dua Bilah Bajak
Abstrak: Bajak subsoil merupakan alat pengolahan tanah pertama yang sering digunakan sebelum pembajakan dengan bajak singkal atau bajak piring untuk memecah lapisan keras di lapisan bawah. Alat ini biasanya digunakan pada tanah yang telah mengalamli pemadatan akibat lalu lintas traktor. Alat ini memiliki tahanan tarik yang tinggi dan biasa ditarik traktor empat roda
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