Judul: Hubungan antara Populasi Penduduk dengan Deforestasi, Penggunaan Lahan , Erosi dan Penurunan Nutrisi Tanah
Abstrak: Tanah hutan tropika merupakan tanah yang rentan terhadap terjadinya degradasi tanah, ditandai dengan kondisi banjir saat musim hujan dan kekeringan cukup parah saat musim kemarau. Hal itu menunjukkan bahwa lahan kurang mampu lagi mengatur kelembaban, sehingga cepat mengering dan jenuh bila kondisi curah hujan berubah. Karena hal ini kemampuan tanah dalam memegang air menjadi berkurang sehingga laju aliran permukaan menjadi meningkat dan pada akhirnya kualitas air lahan menjadi menurun. Perubahan penggunaan lahan hutan menjadi lahan non hutan dianggap dapat meningkatkan laju erosi tanah. Permasalahan utama perubahan penggunaan lahan hutan menjadi bentuk lain adalah berupa penurunan kualitas lahan. Dalam hal ini campur tangan manusia dalam memanfaatkan sumberdaya alam memegang peranan penting terhadap degradasi lahan dan erosi. Laju pertumbuhan penduduk yang cepat pada gilirannya mendorong peningkatan pemanfaatan lahan untuk memenuhi kebutuhan dasar manusia yang berupa sandang, pangan dan papan. Hal Ini berimbas terhadap peningkatan pemanfaatan sumberdaya alam seperti tanah, hutan dan air. Penelitian ini bertujuan untuk mengkaji hubungan antara populasi penduduk dengan penggunaan lahan, deforestasi, erosi dan penurunan nutrisi tanah.
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Judul: Keterkaitan Pertumbuhan Penduduk dengan Perubahan Penggunaan Lahan Pertanian ke Non Pertanian dan Luas Lahan Kritis
Abstrak: Increasing population growth is one of factors affecting the use of a piece of land, where low-land-rent utilization tend to be converted into the higher-land-rent utilization. Land rent of non-agricultural uses which is higher than on-farm agriculture undeniably increase agricultural conversion, then could accelerate land degradation. Land degradation could be due to improper management which is not in accordance with its carrying capacity then initializing degraded land. The purpose of this research is: (1) to identify population growth and agricultural land use change to non-agricultural one, (2) to identify acreage of degraded land, (3) to compare agricultural land rent and non-agricultural uses, and (4) to understand the relationship among population growth, agricultural land use change and the acreage of degraded land. The analytical techniques utilized in this research include: (1) analysis of population growth and spatial technique to identify changes from agricultural land to non-agricultural ones, (2) spasial analysis to calculate hectarage of classified degraded land based on ministry of forestry, (3) descriptive analysis of land rent and the t test, and (4) correlation analysis to understand the relationship among population growth, land use changes and the acreage of degraded land. The results showed that population in Kecamatan Sukaraja grew at 7,6 % and Kecamatan Sukamakmur increased at 0,3 % in the period 2006-2009. The acreage of agricultural land use change to non-agricultural one in Kecamatan Sukaraja was 95,95 ha (4,5%) and in Kecamatan Sukamakmur was 232,74 ha (2 %). Kecamatan Sukaraja was comprised of 1.383,90 ha of non degraded land, 1.613,96 ha of potentially degraded land, 723,34 ha of somewhat degraded land, 166,78 ha of degraded land, and 0,16 ha of severe degraded land. Kecamatan Sukamakmur comprised of 984,07 ha non degraded land, 3.681,50 ha potentially degraded land, 4.330,52 ha somewhat degraded land, 7.658,94 ha degraded land and 44.08 ha severe degraded land. Comparison of the average value of agricultural land rent to non-agricultural one at CI 95 % indicates, that the non-farm business more lucrative than farming. Correlation coefficient of population growth and land use change in Kecamatan Sukaraja was 0,82 and in Kecamatan Sukamakmur was 0,92, the coefficient of population growth and acreage of degraded land of Kecamatan Sukaraja was 0,85 and of Kecamatan Sukamakmur was 0,91, while the coefficient of land use change acreage and degraded land in Kecamatan Sukaraja was 0,90 and in Kecamatan Sukamakmur was 0,98. These suggest positive relationship among all variables at 95% confidence level and implied that the higher population then more intensive changes from agricultural land uses to non-agricultural ones and the wider acreage of degraded land.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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