Judul: Aktivitas Inhibisi α -Glukosidase oleh Flavonoid pada Seduhan Daun Yakon (Smallanthus sonchifolius) untuk Pengendalian Kadar Glukosa Darah secara In Vitro
Abstrak: Smallanthus sonchifolius atau yang dikenal dengan nama yakon adalah tanaman herbal yang dikenal memiliki aktivitas hipoglikemik. Tujuan penelitian ini adalah mengetahui aktivitas inhibisi α-glukosidase dari seduhan daun yakon serta mengidentifikasi kandungan fitokimia dan kandungan total flavonoidnya. Daun yakon kering diseduh dalam 4 konsentrasi berbeda, yaitu, 2, 4, 6, dan 8 gram/100ml air. Uji aktivitas inhibisi α-glukosidase menunjukkan bahwa penggunaan keempat konsentrasi seduhan daun yakon tersebut dapat menghambat α-glukosidase secara signifikan (p = 0.000), dengan konsentrasi tertinggi (8 gram/100ml) menunjukan aktivitas inhibisi tertinggi yaitu sebesar 86%, dan aktivitas terendah ditunjukan oleh konsentrasi terendah (2 gram/100ml) yakni sebesar 56%. Berdasarkan uji fitokimia, komponen kimia yang terkandung dalam daun yakon adalah golongan flavonoid, tanin, steroid dan saponin. Kandungan total flavonoid tertinggi didapat dari seduhan daun yakon dengan konsentrasi 8 gram/100ml sebesar 0.101 mg QE/g.
Keyword: α-glukosidase, flavonoid, seduhan yakon

Judul: Aktivitas Ekstrak, Fraksi Pelarut, dan Senyawa Flavonoid Daun Sukun (Artocarpus altilis) terhadap Enzim α-Glukosidase sebagai Antidiabetes
Abstrak: Breadfruits plants is one of the herbal plants that its leaves has been reported to have biological properties, such as antioxidant, cytotoxic, antiinflammatory, antimicrobial, 5α-reductase enzyme inhibitors, tyrosinase enzyme inhibitors, and chatepsin K inhibitors. This study was conducted to investigate inhibitor activity of extracts and flavonoids compounds from breadfruit leaves against α-glucosidase enzyme using in vitro method. Extract and flavonoid compound are from Indonesian Science Intitute’s research. Inhibitor activity was determined by inhibition percentage and followed by determining the IC50 value. The results showed that extract ethanol, and three other solvent fraction (ethyl acetate, butanol, and hexane) has ability to inhibit α-glucosidase enzyme activity. Based on IC50 values and statistical tests, ethanol and ethyl acetate extracts which has a potential ability to inhibit α-glucosidase enzyme. Ethyl acetate fraction from breadfruit leaves (IC50=6,01 μg/mL) has a better to inhibit α-glucosidase activity than ethanol extracts (IC50=8,89 μg/mL). Based on fourth flavonoid derivative compounds results, which has the best active compound as an antidiabeticis (1-(2,4-dihydroxyphenyl)-3-[8-hydroxy-2-methil- 2-(4-methyl-3-pentenil)-2H-1-ben zopyran-5-yl]-1-propanon) with AC-31code (IC50=16,23 μM). This compound is a flavonoids derivatives compound in dihydrocalcon group.
Keyword: 

Judul: Implementasi Space Time Composite (STC) Data Model Menggunakan Model Data Relasional
Abstrak: The data model is a concept that describes the data stored in the database and the relationship between the data to the user in logic. Development of data models is very important in the design of the database as the basis of the stage of database design to be made. This study aims to apply the concept of Space Time Composite (STC) on the Model Data storage vector data types that can store enough information and describes the process of drafting objects and objects spatiotemporal evolution over time. From the results of the test queries on the data model that have been created, queries in a system are acquired that can help display the information preparation of objects from time to time and know the history of the object polygon and arc that has undergone changes in topology.
Keyword: