Judul: Strategi PenangananTurnover Intentionpada Generasi Z DiTop Three E-commerce Industry, The Strategy of Handling Turnover Intention of Z Generation on The Top Three E-commerce Industries
Abstrak: Dalam dunia kerja dibutuhkan sumber daya manusia yang berkualitas karena memiliki peran sentral sebagai keberhasilan dalam mencapai tujuan perusahaan dengan tepat dan memengaruhi efisiensi organisasi. Sumber daya manusia memiliki berbagai jenis tenaga kerja yang berasal dari generasi yang berbeda. Generasi muda merupakan generasi penerus dari generasi sebelumnya yang saat ini mulai mendominasi jumlah tenaga kerja di Jakarta hingga 70% salah satunya berasal dari generasi Z. Dunia kerja yang memiliki karyawan dari generasi Z salah satunya di sektor e-commerce khususnya ditop three e-commerce industry di Indonesia yaitu Tokopedia, Shopee, dan Lazada. Seiring dengan berkembangnya suatu perusahaan maka akan muncul berbagai permasalahan terkait dengan sumber daya manusia salah satunya berupaturnover intention.Dengan banyaknya kasus resign yang terjadi akan berpotensi timbulnyaturnoverdan menjadi dampak negatif terhadap perusahaan. Tujuan dari penelitian untuk mengidentifikasi banyaknya permasalahanturnover intentionberupa melakukan resign pada generasi Z ditop three e-commerce industry, menganalisis dampak dari beban kerja,work-life balance, dan antar generasi sehingga memengaruhi adanyaturnover intention berdasarkan perspektif generasi Z, dan merumuskan strategi alternatif pada industri e-commerce untuk generasi Z dalam meminimalkan terjadinyaturnover intention. Objek dari penelitian ini dibatasi pada kalangan generasi Z atau mereka yang tergolong lahir antara tahun 1997-2012 yang berdomisili di Jakarta. Jenis data yang digunakan adalah data primer dengan melakukan wawancara dan kuisioner. Teknik pengumpulan data yang digunakan menggunakan analisisStructural Equation Modeling Partial Least Squareuntuk mengidentifikasi permasalahturnover intentionyang terjadi dan pengaruh dari beban kerja,work-life balance, dan antar generasi sehingga terjadi adanyaturnover intentionserta analisisFuzzy Analytical Hierarchy Process untuk merumuskan penentuan strategi alternatif pada industri e-commerce untuk generasi Z terkati meminimalisir terjadinyaturnover intention. Hasil penelitian ini menyimpulkan dari analisis SEM-PLS bahwa adanya pengaruh beban kerja danwork-life balanceterhadapturnover intentionnamun tidak ada pengaruh antar generasi terhadapturnover intention. Dari analisisFuzzy Analytical Hierarchy Processmenunjukkan bahwawork-life balancememiliki nilai yang terpenting pada peringkat pertama dan beban kerja menjadi peringkat kedua. Strategi alternatif utama sebagai bahan pertimbangan dalam permasalahan ini yaitu dengan meningkatkan standar pekerjaan berupa beban kerja yang diselesaikan menggunakan harmoni waktu untuk meningkatkan kepuasan kerja., In the world of work, high-quality human resources are required because they play a central role in achieving a company's goals accurately and influencing organizational efficiency. Human resources consist of various types of workers from different generations. The younger generation is the successor to the previous generation and currently dominates the workforce in Jakarta, with up to 70% of it coming from Generation Z. The workforce in the e-commerce sector, especially in the top three e-commerce companies in Indonesia, such as Tokopedia, Shopee, and Lazada, includes Generation Z employees. As a company grows, various human resource-related issues arise, one of which is turnover intention. The high number of resignations can potentially lead to turnover and have a negative impact on the company. The research aims to identify the turnover intention issues, such as resignations, among Generation Z employees in the top three e-commerce companies, analyze the impact of workload, work-life balance, and intergenerational dynamics on turnover intention from the perspective of Generation Z, and formulate alternative strategies for the e-commerce industry to minimize turnover intention. This research is limited to Generation Z individuals born between 1997 and 2012 residing in Jakarta. The primary data
Keyword: Workload, Work-life Balance,Intergenerational, Turnover Intention,Generation Z

Judul: Analisis Pengaruh Kualitas Kehidupan Kerja terhadap Employee Turnover Intention: Perusahaan Teknologi di Indonesia dan Malaysia
Abstrak: Due to the global pandemic caused by Covid-19, many companies, including tech companies, were forced to hire their employees from home to comply with social constraints and the implementation of health protocols. The changes in the work environment, such as transitioning from working in an office to working from home have impacted the employees’ quality of life, particularly given the differences in characteristics for Generation Y. The impact on the quality of work-life, differences in characteristics for Generation Y, and new work environments in technology companies lead to other changes, such as the quality of working life, leading to employee turnover intentions. As a result, this research was aimed to examine the impact of work-life quality and its impact on employee turnover intention in each dominant generation in technology companies in Indonesia and Malaysia. The quality of Cascio's work-life theory and Olesegun's turnover intention theory were used to develop the indicators. The information was gathered through questionnaires and analyzed by using Second Order Partial Least Squares Structural Equation Modeling. The findings revealed that applying indicators of quality of work-life in Indonesia to technology companies in Indonesia and Malaysia significantly affected the employees’ turnover intention.
Keyword: quality of work-life, turnover intention, tech companies, generation characteristics, PLS-SEM

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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