Judul: Efek Hepatoprotektif Ekstrak Etanol Buah Bakau (Rhizophora mucronata Lamk.) pada Tikus Putih Galur Sprague Dawley Secara In Vivo
Abstrak: Imfflamation in liver tissue caused by free radical metabolism results of toxic compounds such as alcohol, paracetamol, and carbon tetrachloride (CCl4) cause prevalence of liver disease more increased. This research was conducted to investigate antioxidant activity of propagule mangrove (R.mucronata) as a hepatoprotector and determined the level effect of specific liver enzymes, liver MDA, and histopathological studies. Results showed ethanol extract of mangrove propagule has antioxidant activity about 0,72 ppm. Treatment of propagule mangrove extract had a hepatoprotective effect on liver tissue were illustrated by enzyme levels of AST, ALT, MDA, and histopathological studies. Results showed that the best dose showing optimum recovery effect in level AST enzyme was 1 mg/kg BW with activity about 23,6 U/L, in level ALT enzyme was 5 mg/kg BW activity 14,3 U/L, level of MDA was 5 mg/kg BB activity 62,12 U/L. Highest hepatoprotective activity in histopathological studies showed by 5 mg/kg BB dosing.
Keyword: hepatoprotective., propagule mangrove (R.mucronata), antioxidant

Judul: Aktivitas hepatoprotektor ekstrak metanol daun kari (Murraya koenigii .L.) pada tikus putih Sprague dawley, Activity of Curry Leaf (Muraya koenigii. L.) Methanol Extract as Hepatoprotector in Sprague dawley Rats
Abstrak: Curry leaf is being thought as hepatoprotector againts liver damage caused by hepatotoxic agent such as paracetamol. This study was assesing the activity of curry leaf extract in reducing the activity of ALT (alanine aminotransferase) and AST (aspartate aminotransferase) in rats were given high dose paracetamol. Total of 25 rats were used in this research which were divided into 5 experimental groups as follows: normal control group (N), negative control group (KN) (paracetamol dose 500 mg/Kg BW were given 21 days), positive control group (KP) (curliv dose 42.86 mg/Kg BW were given 21 days), dose 200 mg/Kg BW extract group (ED200), and dose 300 mg/Kg BW extract group (ED300). Extracts were given 7 days before paracetamol treatment and continous until end of experiment. Pytochemistry test results showed that curry leaf methanol extract contain alcaloids, tannins, saponins, and steroids. Extract group had not significantly reduced ALT and AST activity (p>0.05) compared to N group. Decreasing ALT and AST activity in ED200 group is 16.21% and 33.82%. Decreasing ALT and AST activity in ED300 group is 33.82% dan 62.60%. Methanol extract curry leaf had hepatoprotector activity although not significantly differences.
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Judul: Asymptotic Distribution of Estimator for the Intensity Function of a Doubly Periodic Poisson Process
Abstrak: In this manuscript, estimation of the intensity function of a doubly periodic Poisson process is discussed. It is assumed that only a single realization of the Poisson process is observed in a bounded window [0,n]. It is also assumed that the period of the intensity function is known. The rate of consistency and asymptotic normality of the estimator are formulated. Finally, a confidence interval for the local intensity function is also formulated.
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