Judul: Desain Taman Sekolah Pendidikan Anak Usia Dini (PAUD) Gema Imani Bogor
Abstrak: Early childhood education is the lowest level education for children of 0-6 years. In this phase, education influence child development. Therefore, educational facilities must support child development. Outdoor facilities are facilities that can made children to learn about nature. Outdoor facilities include a garden designed according to national and international standards to fulfill early childhood education curriculum. Garden design is divided into two main area, front garden and rear garden. Rear garden focused on children's games that use equipment such as swings, slides, balance beam, arch climbers, rope climbing, etc. The lawn in front garden accommodate free activity such as running, walking, jumping, etc
Keyword: Children growth, Curicculum, Design early-childhood school yard

Judul: Desain Taman Sekolah untuk Anak Berkebutuhan Khusus di Sekolah Alam Bogor.
Abstrak: Kondisi lanskap sekolah penting untuk diperhatikan karena sangat mempengaruhi kondisi proses belajar yang mampu membangkitkan peran serta anak didik. Sekolah alam merupakan salah satu bentuk sarana pendidikan yang memperhatikan lanskap sekolah dan bagaimana muridnya menghargai lingkungan. Salah satu sekolah alam terdapat di Tanah Baru, Kota Bogor. Sekolah alam ini memiliki program pendidikan inklusif untuk anak berkebutuhan khusus, dimana anak yang memiliki kebutuhan khusus dapat berinteraksi dengan teman sebayanya. Tujuan dari penelitian ini adalah untuk membuat konsep serta desain taman sekolah yang dapat memberikan fungsi pendidikan dan penyembuhan melalui program dan aktivitas yang dapat menstimulasi pertumbuhan dan perkembangan anak dengan kualitas lingkungan yang baik dan estetik. Metode yang digunakan dalam penelitian ini adalah menganalisis unsur kualitatif dan kuantitatif aspek fisik-biofisik, sosial, dan pendidikan untuk murid berkebutuhan khusus. Metode ini dilakukan melalui empat tahap yaitu: (1) tahap persiapan, (2) menganalisis kondisi eksisting (fisik-biofisik) dan proses pendidikan murid berkebutuhan khusus melalui pengamatan langsung dan studi pustaka, (3) tahap pengolahan data, serta (4) tahap mendesain. Konsep dasar dari taman sekolah ini adalah menciptakan taman sekolah yang edukatif, interaktif, dan dapat digunakan untuk terapi, dengan memadukan kegiatan terapi yang sudah ada sebelumnya. Konsep dasar dari taman ini berasal dari building blocks for learning yang terdiri dari beberapa keterampilan yang didapatkan melalui kegiatan terapi. Konsep desain yang diaplikasikan pada tapak merupakan pengembangan dari konsep building blocks, yaitu building blocks of life atau struktur penyusunan tubuh makhluk hidup dimana sel adalah tingkatan struktural terendah sama seperti sekolah dasar dalam sistem pendidikan. Penelitian ini dibatasi sampai tahap penyusunan desain lanskap dengan hasil akhir berupa site plan yang dilengkapi gambar detail.
Keyword: Desain Terapeutik, Taman Sensorik, Program Pendidikan Inklusif

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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