Judul: Potensi Antibakteri Kurkuminoid dan Nanokurkuminoid Temulawak (Curcuma xanthoriza) Secara In Silico dan In Vitro.
Abstrak: Kurkuminoid termasuk senyawa yang cepat dimetabolisme. Bentuk nanoemulsi dapat menjadi alternatif untuk mengatasi permasalahan tersebut. Antibakteri pada umumnya menghambat pembentukan dinding sel. Enzim MurA berperan penting dalam pembentukan dinding sel bakteri. Penelitian mengenai fungsi kurkuminoid sebagai antibakteri secara in silico serta potensi nanokurkuminoid sebagai antibakteri belum pernah dilakukan. Penelitian ini bertujuan menguji potensi kurkuminoid sebagai antibakteri melalui uji penghambatan enzim UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) secara penambatan molekuler serta mengukur aktivitas antibakteri dari nanokurkuminoid menggunakan uji difusi cakram. Senyawa kurkuminoid menunjukkan nilai energi bebas Gibs lebih kecil dibandingkan dengan ligan pembanding. Nanokurkuminoid memiliki nilai MIC 200 μg/mL untuk ekstrak kasar pada bakteri Escherichia coli serta 400 μg/mL untuk bakteri Bachillus subtilis. Zona bening nanokurkuminoid mendekati dengan senyawa ekstrak kasar dengan konsentrasi senyawa aktif yang kecil. Senyawa kurkuminoid mampu menunjukkan aktivitas antibakteri baik secara in silico maupun dalam bentuk nanokurkuminoid secara in vitro.
Keyword: antibakteri, diffusi cakram, docking, enzim MurA, nanokurkuminoid

Judul: Optimisasi dan Karakterisasi Nanokurkuminoid Tersalut Asam Palmitat
Abstrak: Kurkuminoid merupakan pigmen kuning yang berasal dari tanaman rhizoma Curcuma xanthorhiza Roxb. Bioavailabilitas kurkuminoid sangat rendah di dalam air, laju pelarutan yang lambat, dan ketidakstabilan di dalam pencernaan. Masalah ini dapat diatasi dengan penggabungan senyawa kurkuminoid ke dalam sistem koloid pembawa, seperti nanopartikel. Tujuan penelitian ini adalah membuat nanokurkuminoid sebagai bahan sediaan obat dengan tingkat kestabilan yang tinggi dalam kondisi penyimpanan pada jangka waktu tertentu dan menentukan nanokurkuminoid yang optimum dengan melakukan karakterisasi (ukuran partikel, zeta potensial, dan morfologi) nanokurkuminoid. Homogenisasi selama 5 menit menghasilkan nanokurkuminoid yang optimum dengan ukuran partikel sebesar 166.17 ± 39.64 nm dan indeks polidispersitas sebesar 0.20 ± 0.06. Efisiensi penjerapan kurkuminoid di dalam nanokurkuminoid yang didapatkan sebesar 86.02 %. Serbuk nanokurkuminoid mempunyai morfologi permukaan berongga-rongga kecil dan bentuknya tidak beraturan.
Keyword: kurkuminoid, nanopartikel lipid padat, SEM-EDS, stabilitas

Judul: Thermal Characteristics and Dynamics of Tropical Cyclone over Western North Pacific Ocean: A Case Study of Typhoon Songda (Chedeng) 2011
Abstrak: The frequent occasion of Tropical Cyclone (TC) over Western North Pacific (WNP) Ocean lies from 10˚N to 26˚N and 121˚E to 170˚E. Sources of TC development come from warm ocean temperature where latent heat is released during condensation processes and subsequently concentrated in the boundary layer. Relative humidity at 850-700 hPa is responsible to produce the most intense storm. Meanwhile, weak vertical wind shear between 850-200 hPa is one of the dynamical factors that lead to the development of TC. Pressure level of 850-200 hPa is chosen to minimize the thermodynamic effect in the lower troposphere. Typhoon Songda (Chedeng in the Philippines) or TSC lasted from May 18th to 30th, 2011 and strengthened into powerful Super Typhoon stage between May 24th and 27th. Long curving track and the exhibition of all sequences of TC life cycle, TSC is then considered as an ideal case of TC. The objective of the study with case of TSC is to investigate the role of thermal characteristics and dynamics on TC intensity. The research is carried out by using Advanced Research of Weather Research and Forecasting model (WRF ARW model) version 3.3. Two domains are employed in the model. The first domain situate from 02˚N to 40˚N and 118˚E to 149˚E and cover spatial resolution () of 33.1 km. The second domain situate from 09˚N to 27˚N and 119˚E to 132˚E with of 11 km. Timestep of the model () is 120 seconds. The model is supported by the following physical parameterization, i.e., Yonsei University Scheme (YSU) in the boundary layer, Kain-Fritsch scheme (KF) in the cumulus, and WRF Single-Moment 3-class scheme in the microphysics. Initial meteorological condition prior to the formation of the cyclone is generated using WRF ARW standard-release model. Sensitivity of the model output is obtained from a selected single-parameter change scenarios, namely, 10 % to 20 % decrease and increase of wind shear initial data at 850-200 hPa, and by 10 % to 20 % decrease of relative humidity initial data at 850-700 hPa. The result showed that the negative correlations between wind shear and intensity are found in wind shear scenarios. Wind shears of 10 ms-1 which lead to strengthening of the wind intensity in the early period of Typhoon development are found in wind shear scenarios. The effect of wind shear changes on wind intensity is statistically significant in the 20 % wind shear scenarios. During mature stage, weak wind intensity occurred when wind shear increase as given in the WRF standard-release and the 20 % decreasing scenario. Different situation is found in the 20 % increasing scenario where wind shear tend to weak and lead to strong wind intensity at this stage. Meanwhile, the reduction of moisture supply at 850-700 hPa resulting from 20 % decreasing relative humidity play a major role in the weakening of wind intensity and reduces mechanical energy of the cycle process as much as 300 J kg-1.
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