Judul: Penyelesaian Vehicle Routing Problem pada Pendistribusian Sayuran Dataran Tinggi Menggunakan Algoritme Genetika (Studi Kasus PT Saung Mirwan)
Abstrak: Vehicle routing problem (VRP) is an important issue on a transportation system that aims at minimizing the total vehicle mileage to reduce vehicle operating cost to a minimum. Vehicle routing problem belongs to the class of non-polynomial hard (NP-hard), which generally uses a heuristic approach to find a solution. In this time, Vehicle routing problem resolution will be applied to the distribution of highland vegetables from PT. Saung Mirwan as the vegetable distribution center. The problems that often arise in the distribution of highland plain vegetables is to how minimize the total of transportation costs without sacrificing the goal completion time to reduce the risk of the decline in the quality of vegetables during the trip. Issues will become increasingly complex if the vehicle routing problem is flexible to changes that occur in the limit or the value of decision variables. The problems encountered in this case include heterogeneous multi fleet VRP, single source, single trip, and multi-product. Therefore, this research used genetic algorithm optimization method (GA) to solve the problem. Genetic algorithm is one of the heuristic methods, which is analogous to the process of evolution by natural selection phase, crossover and mutation. In this paper a simulation is performed by searching the optimum solution to the location of the distribution as the destination points. Optimum solutions are obtained in the form of division of highland vegetable distribution channels that meet the existing constraints. As a solution, there was reduction of the distribution time of about 1 hour 58 minutes or an increase in time efficiency by approximately 32.22% and a reduction of the fleet utilization by 1 fleet or an increase of fleet efficiency by 14.28%.
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Judul: The Application of Genetic Algorithm in Vehicle Routing Problem and Its Implementation on Rastra Distribution
Abstrak: Rute pendistribusian kendaraan terkait proses distribusi produk merupakan masalah yang dihadapi produsen dalam memenuhi kebutuhan konsumen. Penentuan rute distribusi kendaraan atau vehicle routing problem (VRP) bertujuan menentukan rute dan penggunaan kendaraan agar biaya yang dikeluarkan minimal. Pada penelitian ini akan dibahas rute pendistribusian kendaraan untuk mengantarkan beras sejahtera dari beberapa gudang penyimpanan ke desa/kelurahan tertentu yang dimiliki Perum Bulog kabupaten Ponorogo untuk satu dari dua belas periode. Salah satu desa/kelurahan memiliki permintaan yang melebihi kapasitas kendaraan, sehingga lokasi tersebut dapat dikunjungi kendaraan dengan pendistribusian terpisah. VRP dapat diselesaikan menggunakan metode eksak dan metode heuristik. Metode heuristik genetic algorithm dengan pencarian solusi awal melalui nearest neighbour diterapkan untuk masalah pendistribusian beras pada periode di Perum Bulog. Solusi yang dihasilkan oleh metode heuristik memiliki waktu yang lebih cepat dibandingkan solusi metode eksak., The vehicle distribution route related to the product distribution process is a problem faced by manufacturers in meeting consumer needs. Determination of vehicle distribution routes or vehicle routing problem (VRP) aims to determine the route and use of vehicles so that the costs incurred are minimal. In this study the route of distribution of vehicles to deliver prosperous rice from several storage warehouses to certain villages will be discussed, which is owned by Perum Bulog in Ponorogo Regency for one of the twelve periods. One of the village has a demand that exceeds the vehicle capacity, so that the location can be visited by vehicles with split delivery. VRP can be solved using exact methods and heuristic methods. The heuristic genetic algorithm method by searching for an initial solution through the nearest neighbour is applied to the problem of distributing rice during the period at Perum Bulog. The solution produced by the heuristic methods has a faster time than the solution of the exact methods.
Keyword: distribution, heuristic method, multidepot, split delivery, vehicle routing problem

Judul: Durability of Specific Immunoglobulin (Ig) Y Againts Influenza and Covid-19 in Sunscreen
Abstrak: The benefit of specific immunoglobulin Y (Ig Y) as an active ingredient in personal care products such as sunscreen has not been properly studied. Our study aims to evaluate the reliability of specific IgY against influenza and the COVID-19 virus in a sample sunscreen product. Specific IgY influenza and COVID-19 viruses were inserted in the sample sunscreen at two concentrations of 0.1% and 0.25%. Three treatments were observed: control (C) sunscreen without IgY, treatment 1 (T1) sunscreen with 0.1% IgY, and treatment 2 (T2) sunscreen with 0.25% IgY. Organoleptic observations were carried out to monitor changes in aroma, color, and texture, and sunscreen sampling was done every week for 6 weeks. The durability of IgY was evaluated using an enzyme-linked immunosorbent assay (ELISA) and a neutralization assay. Organoleptic observation from weeks 1 to 6 showed consistency in its aroma, color, and texture. Enzyme-linked immunosorbent assay and neutralization assay (NA) results of the T1 and T2 groups showed negative results except for sample T1 at week 5, which showed a positive result in the Influenza A ELISA. Based on the results, it seems that IgY concentrations of 0.1% or 0.25% were not optimal. However, this negative result might be due to low concentration of the IgY and the presence of beeswax, which inhibits IgY and causes it to dissolve in distilled water, thus preventing it from being detected in the assay.
Keyword: Immunoglobulin Y, Sunscreen, Influenza, COVID-19, Biological Activity