Judul: Toksisitas Akut Ekstrak Daun Sirsak Ratu (Annona muricata) dan Sirsak Hutan (Annona glabra) sebagai Potensi Antikanker
Abstrak: Soursop plants has been known to have pharmacological activities such as anticancer. Soursop species that are widely found in Indonesia are soursop (Annona muricata) and pond apple (A. glabra). This study has determined the toxicity properties of leaf extracts of these species to brine shrimps larvae and zebra fish embryos. Overall, the pond apple extract showed higher toxicity then the soursop. The best LC50 values were obtained from hexane extract of pond apple leaves, namely 197 μg/mL to brine shrimps larvae and 326 μg/mL to zebra fish embryo. These values indicate a significant correlation as anticancer compounds. This extract of pond apple resulted 8 spots in separation by using thin layer chromatography. 1H-NMR measurement towards these 2 well-separated spot did not show acetogenin component, as previously reported as the anticancer components in soursop plants. Further fractionation of the extract is needed to ensure the structure of the anticancer active component it contained.
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Judul: Acute Toxicity Test of Active Fruit Extract from Soursop (Annona muricata) and Pond Apple (Annona glabra) as an Anticancer Potential.
Abstrak: Penelitian khasiat antikanker dari berbagai bagian tumbuhan sirsak telah marak dilakukan, namun penelitian khasiat antikanker dari bagian buah masih jarang dilakukan. Buah sirsak yang cukup banyak terdapat di Indonesia adalah buah sirsak ratu (Annona. muricata) dan buah sirsak hutan (A. glabra). Penelitian toksisitas dari buah sirsak ratu dan buah sirsak hutan dilakukan dengan dua metode, yaitu metode uji letalitas larva udang (BSLT) dan metode lebih terkini dengan menggunakan embrio ikan zebra (Danio rerio). Nilai LC50 terbaik dari ekstrak buah sirsak ratu dan sirsak hutan diberikan oleh ekstrak etil asetat baik dengan menggunakan metode BSLT maupun dengan embrio ikan zebra. Hasil pengamatan embrio ikan zebra melaporkan bahwa ekstrak etil asetat sirsak ratu merupakan ekstrak dengan daya sitotoksik tertinggi. Uji fitokimia dari ekstrak etil asetat masing-masing buah menghasilkan uji positif pada golongan senyawa alkaloid, tanin, dan flavonoid. Ekstrak etil asetat sirsak ratu menghasilkan 6 noda dari hasil pemisahan dengan kromatografi lapis tipis dan ekstrak etil asetat sirsak hutan menghasilkan 8 noda dengan cara yang sama.
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Judul: Digital Transformation Model and Strategy in Vocational Higher Education
Abstrak: Vocational education stands out for its practical orientation complemented by relevant theoretical knowledge, distinguishing it from academic education which places greater emphasis on theory. Achieving the right balance between practical application and theory is vital for success in vocational education. Notably, hands-on training takes precedence, making vocational education a unique educational pathway. Using SEM, SSM, and ISM, the study delves into digital transformation strategies categorized into four main elements: Demand & Discovery, Learning Design, Learner Experience, and Work & Lifelong Learning. Each element encompasses critical components, signifying a holistic approach to enhancing vocational education. Demand & Discovery focuses on product strategy, marketing, enrollment management, and student recruitment, crucial for understanding market dynamics and student enrollment processes. Learning Design, pivotal in education, covers curriculum design, digital content creation, and teaching strategies, emphasizing engaging and effective learning experiences. Learner Experience encompasses various facets of the academic journey, including learning environments, support services, and assessment methodologies, highlighting the importance of a nurturing ecosystem. Work & Lifelong Learning centers around work-integrated learning, industry engagement, and lifelong learning pursuits, underlining pathways for seamless integration into the workforce. The proposed approach for Indonesian polytechnics' digital transformation is multi-faceted. It starts with establishing a tech-ready infrastructure through thorough technology assessment, strategic budget allocation, private sector partnerships, and pursuit of grants. Skill Empowerment follows, involving tailored training programs aligned with digital tools and continuous assessment of skill relevance. Internal proficiency, a vital aspect, focuses on providing resources and spaces for continuous development, along with a cultural shift towards hands-on learning and real-world application. Industry integration is promoted to enhance experiential learning, emphasizing open communication and industry advisory boards. Global collaboration and policy advocacy further strengthen the transformation process. Partnerships with international institutions, specialized training programs, and online platforms for professional development broaden educational horizons. Addressing limitations in applied master's and doctoral education is vital. Centers of Excellence and hybrid learning models complete the transformational framework. The Integrated Skill Development Ecosystem (ISDE) emerges as the solution to modern vocational education demands, aligning education with industry needs. It integrates real-world experiences, advanced technologies, and tailored learning paths to produce job-ready graduates adaptable to evolving industries. ISDE fosters collaboration between institutions and industries, driving continuous improvement. Implementing ISDE necessitates adapting curriculum, teaching methods, and digital integration, ultimately benefiting industries and producing a skilled workforce, thereby enhancing competitiveness. ISDE holds significant benefits for industries. Graduates possess industry-specific skills, reducing training costs and accelerating productivity. They are adept in the latest technologies, enhancing adaptability. ISDE encourages innovation, problem-solving, and collaboration, fostering a dynamic workforce. Strong partnerships with educational institutions lead to collaborative projects and research. Employing ISDE graduates provides a competitive edge, addresses skill gaps, and contributes to long-term industry growth and economic development. In summary, ISDE enhances vocational education quality, relevance, and effectiveness, benefiting both students and the broader economy.
Keyword: Digital Transformation, Interpretative Structural Modeling, Soft System Methodology, Structural Equation Model, U Theory, Vocational Higher Education