Judul: Hepatoprotector  Potential  of  Rosella  Extract  (Hibiscus  sabdariffa  L)  on  The  Liver  of  Paracetamol-induced  rats.
Abstrak: Paracetamol is one of the most common analgesic and antipyretic for relieving headache and fever. Prolonged use of paracetamol in high dose can produce liver necrosis and damage the kidney. Rosella (Hibiscus sabdariffa L) has the ability to prevent liver necrosis. Therefore, the aim of this research was to determine the hepatoprotector effects of water extract of Rosella in lowering the transaminase acitivity and to examine its ability in regenerating the necrosis of hepatocyte on rats induced by high dose of paracetamol. The change in liver function was determined by microsopical observation with AST (aspartat transaminase) and ALT (alanin transaminase) level. AST and ALT Enzyme analysis was performed using IFCC method. Preparates for histopathology assay were made using modified Andrew Kent method. The induction of rosella water extract with dosage of 1,1 g/mL extract/kg BW, 3,3 g/mL extract/kg BW, and 5,5 g/mL extract/kg BW can lower the ALT activity on 35th day for 61,90%, 62,52%, and 63,27% and AST activity on 35th day for 61,90%, 62,52%, and 63,27% respectively. Observation on histopatology showed that treatment with 1,1 g/mL extract/kg BW had better ability to regenerate hepatocyte compared with both 3,3 g/mL extract/kg BW and 5,5 g/mL extract/kg BW.
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Judul: Aktivitas hepatoproteksi Ekstrak Polifenol Buah Delima (Punica granatum L.) Terhadap Tikus Putih yang Diinduksi Parasetamol
Abstrak: The patient of liver disease more increase. Pomegranate has been higher antioxidant activities and reported as hepatoprotection. The research to make for activity pomegranate polifenol as hepatoprotector and influence in liver histopathology of rat to induction by paracetamol. Polyphenol extracted by mixture solvent acetone:water:acetid acid (90:9.5:0.5). There are 22 rats randomly divided into 7 following group, they are group I allowed fed with strandard pellet, group II allowed fed with strandard pellet and paracetamol 500 mg/kg BB, group III allowed fed with strandard pellet, paracetamol 500 mg.kg BB, and cursil-70 13.3 mg/kg BB, group IV, V, VI, and VII allowed fed with strandard pellet, paracetamol 500 mg/kg BB, and extract polyphenol of pomegranate with doses 13.3 mg/kg BB, 100 mg/kg BB, 250 mg/kg BB, and 500 mg/kg BB for severally group. Experiment was conducted for 34 days and at the last day, observed liver histopathology about number of necrotic cells, apoptosis cells, kupfer cells, and fatty degeneration. Polyphenol extract of pomegranate with dose 500 mg/kg BB to point out possible chase destruction of liver (p<0.05) because number of necrotic cells is low, nothing apoptosis cells, number of kupfer cells is low, and fatty degeneration is low
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Judul: Construction of Strongly Optimal Binary Linear Code with Minimum Distance 9 and 11
Abstrak: A binary linear code of length n over q F is a subspace of n q F . A code has three parameters that attached to it, namely length, dimension, and minimum distance. A code with length n, dimension k and minimum distance d is often called [n, k, d ]-code. Usually, when two parameters are given, then we want to find a code that has the best value for the last parameter. Based on Gilbert- Varshamov bound, if a [n, k, d ]-code exists and can not be expanded, we call it a strongly optimal code. In this paper, we construct strongly optimal code with minimum distance 9 and 11. In constructing the code, we created a theorem and algorithm based on Gilbert-Varshamov bound before we implement the algorithm to MAPLE programming language. Because of computational limitations, the program can only construct up to k = 10 for d = 9 and k = 12 for d = 11.
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