Judul: Kemampuan regenerasi sel hati mencit (Mus musculus ) dengan pemberian karbon tetraklorida
Abstrak: Tujuan Penelitian adalah untuk mengetahui kemampuan regenerasi sel hati mencit dengan pemberian karbon tetraklorida. Hewan yang digunakan untuk percobaan ini adalah mencit galur CBR (Center for Biomedical Research) yang sudah dewasa (berumur kurang lebih 2 bulan dengan berat badan 25-30 gram). Metoda yang digunakan adalah pengamatan histologi jaringan dari preparat awetan yang dikerjakan dengan metoda parafin dan pewarnaan Hematoksilin-Eosin. Disamping pengamatan histologi, juga dilakukan pengamatan terhadap gejala setelah pemberian karbon tetraklorida dan perubahan warna hati mencit. Karbon tetraklorida tergolong bahan kimia yang bersifat toksik terhadap hati. Kerusakan yang ditimbul- kan adalah penimbunan lemak dan nekrosis (kematian sel atau jaringan pada tubuh yang masih hidup) pada sel-sel hati. Kerusakan tersebut dapat diperbaiki lagi oleh sel-sel hati yang mempunyai kemampuan regenerasi yang cepat. Gejala setelah pemberian karbon tetraklorida adalah berkurangnya nafsu makan, lesu dan gerakan menjadi lamban. Secara makroskopik, warna hati menjadi lebih muda dan memperlihatkan bintik-bintik merah. Waktu yang diperlukan oleh sel-sel hati mencit untuk menjadi normal kembali setelah mengalami kerusakan, untuk dosis 0,75 dan 1 ml/kg bb adalah lima hari. Sedangkan untuk dosis 1,25, 1,50 dan 1,75 ml/kg bb adalah sembilan hari.
Keyword: 

Judul: Analisis Histopatologis Organ Hati dan Ginjal Mencit (Mus musculus) yang diberi pretreatment untuk Penyiapan Penelitian Biomedis
Abstrak: Penelitian ini bertujuan untuk mengetahui efek pemberian pretreatment terhadap organ hati dan ginjal mencit. Sebanyak 30 ekor mencit digunakan dalam penelitian ini. Mencit diberikan pretreatment anticacing (albendazol), antibiotik (azitromisin), dan antiprotozoa (metronidazol) yang bertujuan untuk mengurangi dampak adanya parasit dan bakteri. Pretreatment dilakukan selama 29 hari. Mencit kemudian dinekropsi untuk pengambilan organ hati dan ginjal. Organ tersebut di masukkan ke dalam Buffered Neutral Formalin (BNF) 10% untuk persiapan pembuatan sediaan histopatologi dan diberi pewarnaan hematoksilin eosin (HE). Pewarnaan HE untuk mengamati jumlah sel normal, sel yang mengalami degenerasi lemak, degenerasi hidropis, nekrosis, dan infiltrasi radang. Data dianalisa menggunakan uji ANOVA. Hasil penelitian menunjukkan bahwa mencit yang diberi albendazol, azitromisin, dan metronidazol menunjukkan efek toksik ringan pada organ hati, namun tidak menunjukkan efek toksik pada organ ginjal. Mencit jantan lebih direkomendasikan untuk digunakan sebagai bahan penelitian.
Keyword: albendazol, azitromisin, hati, metronidazol, ginjal

Judul: Characteristic of Overshooting Top (OT) Based on  Himawari  8  Satellite  as  a  Convective  Cloud  Feature  that  Generates  Extreme Weather in the Java Island Region
Abstrak: Overshooting Top (OT) is a feature at the top of a convective cloud that is associated with extreme weather. Research on OT in tropical Indonesia is still very limited. The existence of geostationary satellites with wide area coverage and fast frequency observations is useful for observing the fast dynamics of the OT life cycle. Therefore, this study intends to analyze the relationship between OT and extreme weather, updraft and thermodynamic conditions of OT when extreme weather occurs, the best objective method for detecting OT in the day time and night time, and the spatiotemporal distribution of OT in the tropical region of Java Island during the 2018-2021 period. Based on visual analysis using visible channel and Himawari 8 sandwich products, 87% of extreme weather events in Java were accompanied by the appearance of OT. It indicates that the presence of the OT pattern is a convection cloud pattern or feature that is closely related to extreme weather events for the Java Island region. The existence of a time lag between the appearance of OT and extreme weather events on Java Island indicates that the OT of convection cloud can be used as a precursor or nowcasting for the appearance of extreme weather. Most of the convective cloud OT features during extreme weather events on Java Island have altitude that were only able to exceed the altitude of the equilibrium level and few were able to exceed the tropopause level of 9 km – 16 km. The difference in atmospheric conditions during extreme weather events on Java Island, which is in the tropics and subtropics, is a strong and unstable convective energy condition characterized by a larger CAPE, as well as unstable KI, LI, SI and TTI values. It is offset by kinematic factors in the form of a weak vertical wind shear (bulk wind shear 0-6 km) and a higher freezing point height. The difference between extreme weather events in the Java Island region and other tropical regions compared to subtropical regions is the strong updraft speed of convection clouds. The IRW Texture COMB algorithm based on the IRW-Texture Gradient modification and the COMB algorithm shows a significant increase in quality for detecting OT and non-OT pixels in Java. Rainy days with rainfall > 50 mm/day are very common in areas with an altitude of > 500 m. On the other hand, the level of convection activity which is indicated by the presence of OT and lightning is significantly reduced in this area. OT of convective clouds appear more frequently during the DJF season and less frequently during the JJA season. OT often appears during the day time and rarely at night time. Most OTs appear in the central part, away from the south and north coasts of Java Island during the day, while OTs that appear near the south and north coasts of Java Island can appear in the morning or afternoon.
Keyword: convective clouds, extreme weather, Overshooting Tops, Himawari 8 Satellite