Judul: Kemampuan Netralisasi Antibodi Spesifik Avian Influenza H5 Terhadap Beberapa Virus H5N1 Isolat Lapang
Abstrak: Avian Influenza (AI) is well known as Avian flu, Fowl pest, Fowl plaque, or Flu burung, caused by influenza virus type A. This virus is belonged to Orthomyxoviridae and could infect many kind of species such as bird, pig, horse, cat, as well as human. Vaccination is applied to control the disease using inactivated vaccine, which induced the specific antibody against H5 antigen. Passive immunization using specific antisera against H5 antigen is thought to be usefull in controlling the disease especially in the treatment of infected host. In this experiment the neutralization ability of specific antisera against H5 were studied using various field viral isolates subtype H5N1. Antisera was developed in Cavia porcellus which vaccinated with AI subtype H5N1 in activated vaccine. The titre of antisera obtained is 28 used HI test. Four AI virus subtype H5N1 isolates from 2003 to 2006 agains viral were we as tested virus. The neutralization test showed that the sera were able to neutralizing 10 4 EID50 AI virus H5N1 with neutralization index range between 1,1– 1,3. The result indicated that the specific antisera had the neutralization potency to the field virus.
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Judul: Studi Kemampuan Netralisasi Antibodi Anti AI H5N1 Asal Induk Dalam Kuning Telur Ayam Yang Divaksinasi Berbagai Vaksin AI H5N1 Komersial Terhadap Virus AI H5N1
Abstrak: The research was designed to study the capability of antibody anti H5N1 Avian Influenza from egg yolk to neutralize H5N1 AIV. Twenty five hens were divided into five groups, one group as a control group were unvaccinated and four other groups were vaccinated with H5N1 AI inactive vaccine produced by several Indonesia vaccine company. Four H5N1 AI inactive vaccine code VS, VC, VV and VM were vaccinated twice for each group with a month, interval. Group 2 were vaccinated with vaccine code VS, group 3, 4, 5 were vaccinated by vaccine code VC, VV and VM. A week after second vaccination the egg were collected and analyzed the antibody titer against H5N1 AIV by heamagglutination test using H5N1 AIV field isolates as standard virus (Nagrak (2009) and Lawang (2010)). Egg yolk which contains high antibody titer (above 26) were collected and tested against H5N1 AIV field isolates (Nagrak (2009) and Lawang (2010)) by serum neutralization test. The result showed that H5N1 AIV Nagrak (2009) isolate were neutralized by antibody anti H5N1 AIV from egg yolk produced by hens vaccinated with VS,VC,VV and VM, but Lawang (2010) isolate were only neutralized by antibody anti H5N1 AIV from egg yolk produced by hens vaccinated with VS, VC and VM. It is concluded that hens which were vaccinated with H5N1 AI inactive vaccine were able to protect their off spring against H5N1 AIV from the field by transferred maternal antibody trough the egg yolk with titer above 26 Keywords : Maternal Antibody, Antigen, Vaccine, Egg yolk. .
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Judul: Designing Business Process Model and Production Facility Layout for Kombucha Cascara
Abstrak: Proses bisnis kombucha cascara CasTIN melibatkan tiga process participants: KTH Cibulao sebagai pemasok, CasTIN sebagai produsen, dan konsumen/reseller sebagai pelanggan. Proses pascapanen dan pemasokkan bahan baku dilakukan oleh KTH Cibulao untuk mengolah kulit buah kopi menjadi cascara kering lalu dikemas dan dikirimkan ke pihak CasTIN yang telah melakukan pre- order 14 hari sebelum cascara harus diterima. KTH Cibulao akan mengirimkan 10,53 kg cascara per bulan selama masa panen (Maret-Juli. Produksi kombucha dilakukan dalam dua batch dengan total kebutuhan 4,05 kg cascara per bulan. Agar kualitas produk tetap terjaga, distribusi kombucha cascara ke konsumen dilakukan dalam waktu maksimal 2 hari perjalanan. Proses bisnis ini dimodelkan dengan BPMN untuk memudahkan pelaksanaan, monitoring, dan pengelolaan bisnis. Fasilitas produksi terdiri dari 15 departemen yang menyesuaikan kapasitas produksi yaitu 828 botol per bulan. Kebutuhan luas ruangan dilakukan dengan menghitung luas alat produksi, ruang gerak, dan allowance menghasilkan total kebutuhan luas ruang produksi yaitu 56,60 m2. Setelah dilakukan penyesuaian tata letak dengan metode Corelap dan mempertimbangkan aliran produksi, aliran keluar masuk barang, dan efisiensi produksi, luas bangunan ruang produksi mendekati perhitungan kebutuhan luas ruangan yaitu 60,04 m2., The business process of CasTIN's cascara kombucha involves three key process participants: KTH Cibulao as the supplier, CasTIN as the manufacturer, and consumers/resellers. KTH Cibulao handles post-harvest processes and supplies cascara by processing coffee fruit skins into dried cascara, which is then packaged and sent to CasTIN after pre-ordering 14 days in advance. KTH Cibulao provides 10.53 kg of cascara per month during the harvest season (March-July), including annual buffer stock. CasTIN conducts production in two batches, requiring a total of 4.05 kg of cascara per month. Distribution to consumers ensures delivery within 2 days to maintain product quality. BPMN is used to model the business process for ease of implementation, monitoring, and management. The production facility consists of 15 departments with a production capacity of 828 bottles per month. Space requirements are calculated based on production equipment, workspace, and allowances, totaling 56.60 m2. After adjusting layout using Corelap method and considering production flow, material flow, and production efficiency, the actual production space approaches the calculated requirement, totaling 60.04 m2.
Keyword: BPMN, Model proses bisnis, Tata letak ruang produksi, Corelap, Kombucha, Cascara