Judul: Perubahan Penutupan Lahan dan Faktor Penyebabnya di Taman Nasional Rawa Aopa Watumohai, Provinsi Sulawesi Tenggara.
Abstrak: Land cover change is a common phenomenon faced is the conservation area management in Indonesia, including Rawa Aopa Watumohai National Park. This research aims to analyze the land cover change and it’s causing factors. The data carried out on August 2014 using Geographic Information System (GIS) including groundcheck and respondent interview. This research resulted the land cover change from 1981-2013. The most changing land cover is the lowland mountain forest which was converted is to dryland agriculture with 7 553.58 hectare of total area in 1981-2001. Land cover change is caused by economic needs along with reform momentum in 1997, weak law enforcement, lack of the number of personnel, lack of local government support, and landuse needs supported by capital owner.
Keyword: forest encroachment, landcover change, Rawa Aopa Watumohai national park

Judul: Perubahan penutupan lahan dan analisis faktor penyebab perambahan kawasan Taman Nasional Gunung Ciremai
Abstrak: Gunung Ciremai National Park (GCNP) is one of the conservation areas that has been facing forest land cover changes due to uncontrolled activities of people around the area. They have been practicing shifting cultivation system for horticulture that can lead to forest conversion and land cover changes especially fields in GCNP area. Data and information of the conditions in GCNP area can be analyzed through technology Geographic Information System (GIS). The aim of this research was to know rate of land cover and spatial distribution on land cover in GCNP for year periods of 2006-2009 and investigate socio-economic factors that influence expansion in GCNP. Data on sosial and ground control point were taken in GCNP for one month in July 2010. Collected data included spatial data in the form of maps, Landsat image ETM+ year 2006 and TM year 2009 and attributed data including socio-economic conditions, knowledge and attitude of people. Spatial data were analyzed using Geographic Information System (GIS) technology. The results of image processing were analyzed qualitatively and quantitatively using the attribute data to determine its impact on land cover changes. Land cover types in GCNP consisted of virgin forest, pine plant forest, shrubs, fields, water bodies, open land and no data. In the period 2006-2009, there were either increases or decreases in land cover areas. Land cover of open land was decreased by 979.2 ha (-2.26%) with the largest in Pasawahan Subdistrict, virgin forest by 51.21 ha (-0.01%) with the largest in Cigugur Subdistrict and water bodies by 1.62 ha (0.08%). On the other hand, land cover of fields was increased by 178.29 ha (0.18%) with the largest in Argapura Subdistrict, shrubs by 746.73 ha (0.18%) with the largest in Pasawahan Subdistrict and pine plant forest by 92.88 ha (0.06%) with the largest in Cilimus Subdistrict. Socioeconomic factors that influenced expansion of land cultivation into the park areas were rate of income in outside area, knowledge especially on cover function and attitude of people to the existing forest. To anticipate expansion of land cultivation into the forest area, the national park should create alternative beneficial projects in order to improve people income outside national park zone, rehabilitation of zone of natonal park and supervise the activities to people about national park.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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