Judul: Onset, Durasi, dan Gejala Klinis Anestesi pada Kelinci New Zealand White (Oryctolagus cuniculus) dengan Kombinasi Ketamin-Xylazin Intramuskular
Abstrak: The aim of this research was to expound the onset, duration, and clinical signs observed on anaesthesia phase using ketamine-xylazine combination in New Zealand White rabbits. Fifteen New Zealand White rabbits (Oryctolagus cuniculus) were randomly subjected into three groups of five animals each. Those in group A were anaesthetized using a combination of 35 mg/kg ketamine and 5 mg/kg xylazine given i/m. Group B animals were anaesthetized using a combination of 40 mg/kg ketamine and 5 mg/kg xylazine while group C were anaesthetized using a combination of 45 mg/kg ketamine and 5 mg/kg xylazine, both given i/m. The result of this study indicated that the onset of anaesthesia marked by loss of pain response differ not significantly among the three groups (P < 0.05). Duration of anaesthesia and recovery significantly differ (P < 0.05) as the dose of ketamine increased. The onset of anaesthesia clinical signs within induction phase showed significant differences on sternal recumbency, lateral recumbency, and constricted pupil. Meanwhile the onset of anaesthesia clinical signs showed no significant differences (P<0.05) within recovery phase. It was concluded that onset of anaesthesia and clinical signs in induction phase were directly proportional as the ketamine’s dose increased. Meanwhile duration of anaesthesia and duration of recovery were inversely proportional with the dose increasing.
Keyword: anesthesia, ketamine-xylazine, New Zealand White, rabbit

Judul: Gambaran Fungsi Jantung Kelinci Domestik pada Pembiusan Jangka Panjang Xylazin-Ketamin dengan Pencitraan Ekhokardiografi
Abstrak: Combination of xylazine-ketamine are commonly used anesthesia in veterinary medicine either in the minor or mayor surgery. The purpose of this study was to determine the effect of long-term anesthesia xylazine-ketamine combination on heart dynamics or performace of domestic rabbit’s assessed using Motion-mode echocardiography imaging. Xylazine-ketamine was administered to the male adult rabbit intra muscular for induction and through intra vena drip method for 7 hours maintenance. Evaluation of heart performance was assessed by Motion-mode echocardiography imaging. The results showed that administration of long-term anesthesia causes effect on the rabbit heart such as decrease of LVW (left ventricular wall), HR (heart rate), SV (stroke volume), CO (cardiac output), FS (fractional shortening), and EF (ejection fraction) value and increase of LVID (left ventricular internal dimention), EDV (end diastolic volume) dan ESV (end systolic volume) value. These results clearly showed the decrease of cardiac performance due to administration of long-term anesthesia that will inhibit the release of norepinephrine through the pressure of the sympathetic nervous system. The conclusion of this study is the long-term anesthesia xylazine-ketamine will result in a decrease of cardiac performance.
Keyword: xylazine-ketamine., long-term, heart, echocardiography, esthetica

Judul: Formulasi Hamiltonian untuk Menggambarkan Gerak Gelombang Soliter Dimensi Tiga di Permukaan Laut
Abstrak: Gelombang permukaan adalah gelombang yang terjadi perbedaan rapat massa antara air dan udara. Salah satu gelombang permukaan yang ditinjau adalah gelombang soliter. Formulasi gelombang soliter dilakukan dengan menggunakan formulasi Hamiltonian.
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