Judul: Peningkatan Kinerja Sistem Spatial Data Warehouse Kebakaran Hutan Menggunakan GeoServer dan GeoMondrian
Abstrak: Forest fire can be periodically detected by satellite as hotspot areas that occur at specified time and location. The frequency of forest fire in Indonesia is high so the data collection of hotspots will be very large. That data collection of hotspots can be stored into specific storage such as data warehouse. A data warehouse system of forest fire was built in the previous research using GeoServer as web map server and GeoMondrian as OLAP Server. However, that system still has some limitations such as the poor system runtime and the low amount of retrieved hotspots. In this research, the system would be reconfigurated in order to fix those limitations so that the system performance would increase. The configuration involves some part of the system including Java Runtime Environment, database source, data cube schema, and error handling in OpenLayers. It has resulted 155 ms higher speed of runtime and 1310 higher number of retrieved hotspots.
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Judul: Sinkronisasi antara Visualisasi Peta dan Query OLAP pada Spatial Data Warehouse Kebakaran Hutan di Indonesia
Abstrak: This research is a continuation from the previous research concerning data warehouse and spatial OLAP forest fire in Indonesia based on web using framework GeoMondrian and Geoserver. In the previous research, OLAP analysis process and hotspot location visualization are performed separately. In this research, the synchronization between OLAP analysis process and hotspot location visualization uses Spatialytics framework. This synchronization can be done because GeoMondrian and OpenLayers are embedded on Spatialytics, therefore OLAP analysis process and hotspot location visualization can be done by using just one query, that is MDX. This research develops a system which uses Spatialytics framework, PostGIS as spatial database, and GeoMondrian as spatial OLAP server. The system uses snowflake scheme with one table of fact and three dimensions consisting of the time dimension, the satelite dimension, and the location dimension. The System is built with threetier architecture consisting of the bottom layer, middle layer, and the top layer. The advantage of this system compared to the previous one is that this system takes only one input query, which is MDX to do OLAP analysis and show hotspot location. OLAP operations such as roll up, drill down, and slicing has been implemented in this system whilst dicing has not been implement because of Spatialytics limitation. For further research, system can be developed that is capable of dicing operation, data modification, such as insert, delete and update, without changing any scheme or structure.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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