Judul: Analisis Kekuatan Berdasarkan Pengujian Destruktif Dan Kekakuan Lentur Berdasarkan Pengujian Non Destruktif Osb (Oriented Strand Board) Dari Campuran 3 Jenis Bambu
Abstrak: Strength Analysis Based on Destructive Testing and Stiffness Bending Based on Nondestructive Testing of OSB (Oriented Strand Board) Made from Mixtures Three Bamboo Species
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Judul: Sifat Fisis dan Mekanis Bambu Oriented Strand Board (BOSB) pada Berbagai Jenis Bambu dan Kadar Perekat
Abstrak: Bambu sudah dimanfaatkan sebagai bahan baku konstruksi, furniture, kertas, papan komposit, termasuk papan OSB bambu dan lain-lain. Perekat fenol formaldehida (PF) digunakan pada penelitian ini dalam rangka untuk menurunkan biaya produksi. Penelitian ini bertujuan untuk menganalisis sifat fisis-mekanis OSB, menentukan OSB terbaik dari dua jenis bambu dan tiga kadar perekat dan menduga sifat mekanis lentur OSB bambu dengan melihat hubungan SWV (stress wave velocity) dan MOEd (modulus of elasticity dinamyc) dengan MOEs (modulus of elasticity static) dan MOR (modulus of rupture). Bambu yang digunakan adalah tali (Gigantochloa apus (J.A & J.H. Schultes) Kurz) dan hitam (Gigantocholoa atroviolacea Widjaja). Strand-strand dikeringkan di dalam oven pada suhu 60 oC sampai mencapai kadar air (KA) sekitar 5%. Kadar perekat fenol formaldehida yang digunakan yaitu 6%, 8% dan 10% dan penambahan parafin sebanyak 1%. Pengujian yang dilakukan antara lain geometri strand, sifat fisis (kerapatan, kadar air, daya serap air, dan pengembangan tebal) dan sifat mekanis (modulus elastisitas statis (MOEs), modulus patah (MOR), internal bond (IB), dan pegang kuat sekrup (KPS)). Metode pengujian nondestruktif (NDT) juga dilakukan untuk menduga nilai stress wave velocity (SWV) dan modulus elastisitas dinamis (MOEd). Standar yang digunakan yaitu CSA 0437.0 (grade 0-2) untuk oriented strand board (OSB).
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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