Judul: Analisis Perubahan Rencana Tata Ruang Wilayah, Kesesuaian Pengalokasian Ruang, dan Nilai Land Rent di Kecamatan Bogor Selatan, Kota Bogor
Abstrak: Spatial planning of Bogor City by years 2011-2031 is a refinement of the 1999-2009’s Spatial Planning to adjust with 26thsummon of 2007. Southern District of Bogoris functioning as an area of cultivation. Therefore, the aim of this study were (1) to know the type of land use, (2) to analyze the changes in the allocation of space on 1999-2009 to 2011-2031 Spatial Planning, (3) to analyze the suitability of space utilization based on 1999-2009 and 2011-2031 Spatial Planning, and (4) to analyze the value of land rent for trade, settlement, and agriculture.Types of land use in Southern District of Bogor beginning by the most extent are residential, garden, farms, fields, residential real estate, bushes, cemetery, lake, trade and services, industrial estates, river, sport fields, and government office. Allocation of space on 1999-2009 in 2011-2031’s Spatial Planning changed from cultivated areas (100%) to protected areas (8.3%) and cultivated areas (91.7%). Protected areas included by infrastructure border and river border. There was an increasing vast of Spatial Planning on agricultural, industrial estates, and cementery areas. Besides, there was a decreasing vast of Spatial on residential, trade and services, government office, and green space areas. Suitability of space utilization in Southern District of Bogor based on 1999-2009’s Spatial Planning are agricultural (88%), residential (98%), trade and services (45%), industrial estates (33%), government office (46%), green space (83%), and cemetery (63%). Suitability of space utilization in Southern District of Bogor based on 2011-2031’s Spatial Planning are agricultural (95%), residential (94%), trade and services (52%), industrial estates (58%), government office (41%), green space (97%), and cemetery (88%). The average value of land rent for trade and services Rp. 633.312 /m2/year, residential Rp. 16.298 /m2/year, and agricultural Rp. 7.932 /m2/year.
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Judul: Penggunaan/Penutupan Lahan dan Kaitannya dengan Pertumbuhan Ekonomi Wilayah (Studi Kasus Kota Bogor)
Abstrak: Rapid population growth will implied the need for space to accommodate their activity. And one of it manifested in the shape of built up area. On this land then this population do their activity, individually or in a group. The aims of this study were namely, to analyzes changes in land use/land cover of Bogor Municipality between 2005 and 2007, to analyzes the influence of economic factor to the land use/land cover compositions, and to analyzes the consistency between land use of the Bogor Municipality in 2007 and Regional Spatial Plan (RTRW). In 2005, Bogor Municipality land use/land cover was dominated by settlement with 31,1% (3.563,01 Ha), followed by paddy with 23,2 % (2.656,07 Ha) and urban forest with 13,9% (1.592,75 Ha). There were no change in the land use/land cover domination in 2007. Settlement still dominating Bogor Municipality land use/land cover with a little increase, which is 31,3% (3583,98 Ha). Paddy with the same percentage, which is 23,2% (2658,88 Ha) on second place and urban forest with 13.9% (1592,79 Ha) in third place. Between 2005 and 2007, there were 109,14 Ha land use/land cover change that occurs in Bogor Municipality. The transformation from non used space became a residential is the most dominating transformation, which reach 45 Ha. Followed by the transformation from field became a residential with 21,75 Ha and the transformation from non used space became fields is on the third place with 12,67 Ha. The growth of the population equal to the demand for housing. This is the reason for the developer to build new residential. The Bogor outer ring road project is also suspected as the trigger to the growth of residential area. With this infrastructure built, these new residential will have the best accessibility to or from Jakarta, which is the centre of economic activity in Indonesia. Bogor Municipality consist of two hierarchy, first hierarchy and third hierarchy. The third hierarchy consist of 57 villages. While another eleven 11 were classified as the first hierarchy. Essentially, the first hierarchy is the centre v of general activity and economic activity, which is why the first hierarchy is dominated by built up area, while the third hierarchy is commonly dominated by the non built area. There are two kinds of the inappropriateness between Regional Spatial Plan and 2007 land use. The first one is the Regional Spatial Plan which was built less than the allocated plan, which is dominated by the allocation for health facilities, with 1,8 Ha over 18,3Ha which was allocated. The second is the Regional Spatial Plan which was built more the allocated plan, which is dominated by the allocation for agriculture with 128,4 Ha allocated, but built up to 408,1 Ha. By identifying the inconsistencies of actual land use to Regional Spatial Plan (RTRW), spatial plan deviations in Bogor Municipality can be identified.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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