Judul: Penerapan Metode CART dan Agregat Bootstrap dalam Klasifikasi Status Gizi Balita Di Kecamatan Taman Sari, Kabupaten Bogor.
Abstrak: Nutrition problem is a multidimensional problem that affect health and productivity of Indonesian society. The number of short nutritional status (stunting) and high malnutrition is a serious health problem because it picturizes life for the next 100 years. About 90% of the short children problems in the world occur in 36 countries, and the rank of Indonesia is number five. The purpose of this study is to determine the factors that affect the nutritional status of children and evaluate the stability of classification trees with bootstrap aggregating method.The research is conducted at Taman Sari subdistrict, Bogor with the number of samples 120 mothers who have toddlers. Statistical analysis used to analyze the factors that influence the nutritional status of children is the method of CART (Classification and Regression Tree). CART is a method of data exploration which uses decision tree technique. This study also applies bagging method (bootstrap aggrergating) to evaluate the stability of classification trees generated by CART. The results of the classification tree formed produces optimum tree with eight terminal nodes. Explanatory variables into the main node is the nutritional behavior. Level of accuracy for the CART method was 69.17%.The percentage of the classification on the delimitation of the best z using z-score -2.5 SD with level of accuracy 76.67% and 88.33%, and z-score -3 SDwith level of accuracy 73.33% and 79.17%. Bagging method has been able to evaluate the stability of classification trees by 79.28%.
Keyword: bootstrap aggregating, CART, the nutritional status of children

Judul: Penerapan metode pemangkasan  dalam CART (Classification and Regression Tree) studi kasus : Pendugaan status gizi anak di Kecamatan Bogor Timur
Abstrak: CART (Classification and Regression Tree) merupakan metode eksplorasi data yang mampu menganalisis hubungan kausal antara peubah tidak bebas dan peubah bebas dalam jumlah data yang berukuran besar dan komplek yang terdiri dari data kategorik (nominal dan ordinal) dan pengukuran (interval dan rasio). CART merupakan metode yang sangat tepat dalam penelusuran peubalı penyebab (penjelas). Penerapan penelusuran peubah penyebab dalam penelitian ini untuk menyelesaikan permasalahan pendugaan status gizi anak. Penerapan metode pemangkasan dalam CART bermanfaat untuk menghindari terjadinya over fitting dan under fitting dalam membentuk pohon regresi. Penerapan ini menggunakan data status gizi anak sebelum dan sesudah pembinaan di Kecamatan Bogor Timur dengan tidak membandingkan kondisi data sebelum dan sesudah pembinaan. Pemangkasan paling baik yang dihasilkan, yaitu pemangkasan berdasarkan penurunan nilai devian tertinggi karena mempunyai metode yang lebih praktis dan dapat digunakan untuk contoh yang berukuran kecil, sedangkan pemangkasan berdasarkan penurunan nilai sisaan relatif penggantian ulang tertinggi dan selisih nilai tertinggi atau jarak terjauh antara nilai sisaan relatif validasi silang lebih akurat dalam penelusuran peubah penyebab dalam menduga peubah respon walaupun dengan ukuran contoh yang kecil. Penerapan model CART untuk menduga status gizi anak menghasilkan peubah penyebab yang konsisten dan logis, oleh karena itu model CART merupakan model yang tepat untuk digunakan dalam pendugaan status gizi anak.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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