Judul: Aktivitas Antikanker Ekstrak Metanol Berbagai Bagian Pohon Jabon (Anthocephalus cadamba Miq.)
Abstrak: The objectives of this research were to determine the percentage of the methanol extract leaves, bark, and wood of the white jabon tree, and to examine the activity of such anticancer extract by in vitro (pretreatment with BSLT method, and antiproliferation of the MCF-7 breast cancer cell, HeLa cervix cancer cell, and Vero normal cell), as well as to analyze the content of chemical extract having the highest anticancer activity qualitatively through qualitative phytochemistry and quantitatively by using GC-MS pyrolisis. Antiproliferation test was conducted by MTT method. The result of this research revealed that the leaves of the white jabon obtained the highest extract at 13.22%. The extrac of bark and wood were very toxic to the larvae of lobster A. salina at the value LC50 197 μg/mL and LC50 122 μg/mL. Anticancer activity of bark extract towards MCF-7 cancer cell (IC50 91 μg/mL) was higher than the part its wood (IC50 312 μg/mL). However, bark extract was higher towards HeLa cancer cell (IC50 3 μg/mL) than MCF-7 cancer cell (IC50 91 μg/mL). Bark extract was very potential to be developed as anticancer agent to cervix and breast, and kept in save in normal cell (IC50 288 μg/mL). The result of qualitative analysis in bark extract positively consisted of phenol, flavanoid, alkaloid, saponin, triterpenoid, and glycoside. Pyrolisis analysis of GC-MS showed that in bark extract was detected the derived of fatty acid and phenol.
Keyword: HeLa cell, toxicity, white jabon, MCF-7 cell, Vero cell

Judul: Antiproliferation activity of psidium guajava leaf exctract on breast cancer MCF-7 Cells
Abstrak: Ekstrak daun jambu biji memiliki bahan aktif yang diharapkan mampu menghambat proliferasi sel kanker dan tidak bersifat toksik terhadap sel yang normal. Oleh karena itu, penelitian ini bertujuan mengevaluasi efek antiproliferasi dari ekstrak daun jambu biji terhadap sel kanker payudara MCF-7. Evaluasi hambatan ditentukan dengan menggunakan uji 3-(4,5-dimetiltiazol-2-il)-2,5-difenil-tetrazolium bromida (MTT). Hasil penelitian menunjukkan kandungan metabolit sekunder simplisia daun jambu biji adalah flavonoid, saponin, tanin, dan triterpenoid. Nilai IC50 dari ekstrak kasar etanol 70% terhadap sel MCF-7 sebesar 35 ppm. Ekstrak menghambat pertumbuhan sel kanker payudara MCF-7 secara maksimal pada konsentrasi 100 ppm tanpa menghambat pertumbuhan sel normal Chang. Fraksionasi dengan eluen terbaik campuran kloroform dan metanol (6:4) menghasilkan fraksi 4 yang memiliki sifat toksisitas selektif paling baik dengan nilai IC50 sebesar 378 ppm. Berdasarkan analisis gugus fungsi menggunakan spektrofotometer infra merah terhadap fraksi 4, terdapat serapan C=C aromatik, ulur –CH2 asimetrik, C–O eter, dan –OH. Kata kunci: daun jambu biji, sel MCF-7, spektrofotometer infra merah, uji MTT, Guava leaf extract contains active compound that could inhibit the proliferation of cancer cells and non-toxic to normal cells. Therefore, the purpose of this study was to evaluate the antiproliferation effect of guava leaf extract on breast cancer MCF-7 cells. MTT (3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide) assay was used to test the anticancer effect. The result showed that guava leaf contained secondary metabolites as flavonoids, saponins, tannins and triterpenoids. The IC50 value of 70% ethanol extract to MCF-7 cells was 35 ppm. The ethanol extract inhibited the proliferation of MCF-7 at 100 ppm without inhibited Chang cells. Further fractionation with chloroform and methanol (6:4) as eluent gave a fourth fraction showing excellent selective toxicity with IC50 value of 378 ppm. Based on functional group identification on this particular fraction using infra-red spectrophotometer, there were aromatic C=C, asymmetric –CH2 stretching, C–O ether, and –OH absorptions. Keywords: Psidium guajava leaves, MCF-7 cell, infra-red spectrophotometer, MTT assay
Keyword: daun jambu biji, sel MCF-7, spektrofotometer infra merah, uji MTT

Judul: Dampak Volatilitas Nilai Tukar Terhadap Inflasi Sektoral: Penerapan Model Overshooting Dornbusch Di Lima Negara Asia
Abstrak: This paper is to examine the application of the theory of Dornbusch overshooting in five countries Asia, Indonesia, Malaysia, Singapore, South Korea, and China. Theory of exchange rate overshooting Dornbusch, an increase in the money supply in the short term will cause the exchange rate to depreciate more than the value of long-term depreciation. The implication of these conditions is in his attempt to get to the economic balance, speed of adjustment of prices of goods and services will be slower than the speed of adjustment that occurs in the exchange rate. In the results of this study can be explained that Indonesia, and Singapore has experienced the phenomenon of overshooting. China, South Korea and Malaysia did not has experience this phenomenon, due to the exchange rate regime adopted by the State. Volatility of exchange rate can affect sectoral inflation, phenomenon overshooting exchange rate be held in Indonesia, Singapura and Malaysia.
Keyword: sectoral inflation, overshooting, money supply