Judul: Kajian Tipologi Desa Berdasarkan Status Perkembangan dan Kemandirian Desa.
Abstrak: Kebijakan pembangunan di masa lalu cenderung lebih mengedepankan kepada pentingnya pencapaian pertumbuhan ekonomi. Pembangunan desa dan kawasan perdesaan secara komprehensif merupakan faktor penting bagi pembangunan daerah, pengentasan kemiskinan, dan pengurangan kesenjangan antar wilayah. Perencanaan pembangunan daerah memerlukan informasi dan data mengenai perbandingan perkembangan dan kemandirian antar desa. Penelitian ini bertujuan untuk mengidentifikasi status perkembangan desa, mengidentifikasi status kemandirian desa, dan memetakan tipologi desa berdasarkan status perkembangan dan kemandirian desa. Penelitian dilakukan di Kabupaten Bogor, penentuan status perkembangan desa dibangun dengan 11 indikator sedangkan status kemandirian desa didasarkan atas enam indikator. Penelitian menggunakan data sekunder dari BPS yaitu PODES Tahun 2014 atas 434 desa di Kabupaten Bogor. Data primer digunakan untuk mendukung hasil analisis diambil dengan observasi lapangan pada dua desa perwakilan tipologi yang dipilih. Data kualitatif dipakai untuk mendukung data-data kuantitatif sebelumnya. Berdasarkan status perkembangan, terdapat 187 desa berstatus desa berkembang dan 247 desa berstatus desa tertinggal. Secara spasial, wilayah yang maju cenderung tersebar merata di daerah pinggiran perkotaan dan beberapa kecamatan yang berada di posisi sebelah utara dari Kabupaten Bogor. Berdasarkan status kemandirian terdapat 78 desa dan 356 desa tergolong tidak mandiri. Secara spasial wilayah yang cenderung tidak mandiri air dan pangan ialah wilayah yang berada di Kabupaten Bogor sebelah utara. Sedangkan, wilayah yang mandiri relatif ada di bagian barat dan timur dari Kabupaten Bogor. Berdasarkan status perkembangan dan kemandirian yang disusun sebelumnya, maka terdapat tiga desa masuk tipologi I (maju dan mandiri), 184 desa tipologi II (maju dan tidak mandiri) yang secara keruangan berada di dekat daerah perkotaan, seperti Kecamatan Citeurep, dan Kecamatan Bojonggede. Selanjutnya, ada 172 desa termasuk tipologi III (tertinggal dan tidak mandiri) yakni daerah ini berada di sebelah ujung timur dan ujung barat dari Kabupaten Bogor meliputi Kecamatan Jasinga, Kecamatan Cibungbulang; dan terakhir ada 75 desa termasuk tipologi IV (tertinggal dan mandiri) meliputi beberapa kecamatan yakni Kecamatan Sukajaya, dan Kecamatan Sukamakmur. Nilai korelasi Spearman antara perkembangan dan kemandirian desa adalah -0,371 artinya bahwa semakin maju status perkembangannya cenderung semakin tidak mandiri. Sebaliknya, kecenderungan desa mandiri adalah desa-desa yang relatif tidak maju atau tertinggal. Berdasarkan pada hubungan tersebut, muncul gagasan bahwa di Kabupaten Bogor menghasilkan muka dua pembangunan.
Keyword: Pembangunan wilayah, status perkembangan desa, status kemandirian desa, tipologi desa

Judul: Analisis Dinamika Pembangunan Perdesaan di Kabupaten Bogor
Abstrak: Success of rural development requires a multifaceted and comprehensive approach to the unique characteristics of rural area that are different from each other. This research is aimed to analyze the dynamics of rural development in Bogor Regency, linkage between productivity and classification of rural, and conformity between development program with the characteristics of the rural (local specific). The advantage of this research are describing the figure of characteristic and productivity of rural in Bogor Regency as well as a source of reference and direction in formulating rural development policies in Bogor Regency. The methods used in this research is Boolean logic rules in analyzing rural typology, ordinal scale scoring system refer to Permendagri No.12 in 2007 in deciding classifications and categories, and Malmquist Index in measuring rural productivity. The dynamics of rural development in Bogor Regency from 2003 to 2011 has shown a very rapid progress due to the decreasing number of Swadaya villages and increasing number of Swakarya villages with some difficulties to become Swasembada villages. The result of productivity analysis of villages in Bogor Regency in 2003-2011 show Malmquist Index average for Swasembada village is 1,55 , Swakarya village is 1,45 and Swadaya Village is 1,15. The third classification village has growth in productivity. This dynamic is followed by a massive shift from typology of rice to typology of industrial / service within the last ten years indicating a very high the conversion of agricultural land and the decreasing agricultural potential that lead to lack of self-sufficiency and food security. The determinant problems of the Swadaya Villages is in Mula category (basic needs), Swakarya Villages is in Madya category (institutional), while Swasembada villages only in Madya category and Lanjut category (governance) since they do not have Mula category. There are spatial, program and typology biases in the implementation of national programs such as rural PNPM, regional programs and local programs that are more focused to Swakarya villages, compared to Swadaya villages and lack of typological consideration.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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