Judul: Aktivitas Ekstrak Etil Asetat Daun Mimba sebagai Antihiperglikemik pada Tikus yang Diinduksi Aloksan
Abstrak: The aimed of this study to assess the potency of ethyl acetate extract of neem leaves which has the effect anti-hyperglycaemia in white rat as experimental animals. Eighteen male white rats age 4-5 months was divided into six groups: first as a normal control group (K1) which has given aquadest, second as a negative control group (K2) which has given aquadest, a third group as a positive control (K3) were have given glibenclamide; the treatment group (KP1, KP2, KP3) were have given ethyl acetate extract of neem leaves dose of 30, 60, 90 mg/kg BW. All groups except K1 were induced by alloxan dose 150 mg / kg BW. Phytochemical screening of neem leaves contained the active ingredients such as flavonoids, saponins, and tannins. Blood glucose concentrations in rats was examined before and after induction of alloxan and after treatment. The results showed that the ethyl acetate extract of neem leaves significantly affected the decrease blood glucose concentrations. The effective dose to decrease blood glucose concentrations are 60 and 90 mg / kg BW. The study concluded that the ethyl acetate extract of neem leaves can be recomended as anti-hyperglycaemia effect.
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Judul: Potensi Antihiperglikemia Ekstrak Kulit Kayu Mahoni (Swietenia macrophylla King) pada Tikus yang Diinduksi Aloksan
Abstrak: Mahogany bark (Swietenia macrophylla King) contain active compound which have antihyperglycemic activity. This research was aimed at investigating the effect of mahogany bark on blood glucose concentration and histopathology in rat’s pancreas which induced alloxan. On this research Sprague-Dawley rats were divided into 5 groups, each group were 5 rats, A (NaCl 0.9% + aquades), B (aloxan + aquades), C (aloxan + Glibenclamide 0.25 mg/kg BW), D (aloxan + water extract of mahogany bark 250 mg/kg BW), and E (aloxan + metanol extract of mahogany bark 250 mg/kg BW). Blood glucose concentration defined by using Accu-Chek® Active glucometer. Pancreas histopathology analysis was carried out with Haematoxylin Eosin (HE) staining and observed under light microscope. Result showed water extract of mahogany bark can decrease blood glucose concentration from 173,2 mg/dL to 94 mg/dL (45,73%) and methanol extract of mahogany bark can decrease blood glucose concentration from 118,6 mg/dL to 88 mg/dL (25,80%). Result of histopathology showed there was improvement on pancreas gland. Methanol extract given better restoration effect on the islets of Langerhans than water extract
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Judul: Hamiltonian formulation for linear waves motion in two layers fluid
Abstrak: The surface wave could be considered as a wave that separates two fluids, namely water and air. Based on this assumption, it is introduced the interfacial wave, a wave between two layers of fluid with different density. The formulation of interfacial waves motion begins with deriving the base equation of irrotational ideal fluid. Furthermore, according to irrotational fluid assumption, the base equation can be stated in velocity potential. In this derivation, the fluids domain is assumed to be restricted by rigid lid boundary conditions, both at the upper and lower limit. Therefore, the interfacial waves motion can be explained in a hamiltonian formulation. In the hamiltonian formulation, total energy is defined as the sum of kinetic and potential energy. The hamiltonian system is obtained from reduction of kinetic energy by using the Dirichlet Neumann Operator. The resulted kinetic energy equation is nonlinear. Therefore, this form is linearized by first part of the Taylor expansion. This linearization gives a dispersion relation of linear wave. Based on this dispersion relation, the phase speed of the linear wave depends on the density ratio of the two layers fluid.
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