Judul: In Silico Analysis of the Potential Bioactive Compounds in Pulai (Alstonia Scholaris) as 3-Chymotrypsin-like Protease Enzyme Inhibitor (EPI_ISL_576383)
Abstrak: Coronavirus Disease (COVID-19) merupakan pandemik global yang disebabkan oleh infeksi SARS-CoV-2. Senyawa dengan aktivitas antivirus dapat dijadikan sebagai kandidat obat COVID-19 dengan menginhibisi enzim 3CLpro yang berperan penting dalam proses replikasi SARS-CoV-2. Alstonia scholaris memiliki senyawa aktif antivirus, namun potensinya sebagai inhibitor 3CLpro belum diketahui. Penelitian ini bertujuan menguji potensi senyawa aktif pulai sebagai inhibitor 3CLpro (EPI_ISL_576383) secara in silico. Penambatan molekuler yang dilakukan terhadap 75 ligan uji menunjukkan terdapat delapan ligan uji yang memiliki afinitas pengikatan yang lebih baik dibandingkan JRY7 dan dua ligan pembanding berdasarkan energi bebas Gibbs, konstanta disosiasi, dan interaksi terhadap residu penting, yaitu E-16-formyl-5α-methoxystrictamine, 17-Oacetylechitamine, nareline, alschomine, asam ursolik, nareline-metil-eter, 6-7- seco-angustilobin-B, dan picralinal. E-16-formyl-5α-methoxystrictamine merupakan senyawa penciri dari Alstonia scholaris yang menjadi ligan dengan energi bebas Gibbs dan konstanta disosiasi terendah (-6,0350 kkal/mol dan 0,0038x104 µM) yang berinteraksi dengan 11 residu penting di sisi aktif 3CLpro. Kata kunci: COVID-19, 3CLpro, Alstonia scholaris, in silico, Coronavirus Disease (COVID-19) is a global pandemic caused by infection with SARS-CoV-2. Compounds with antiviral activity were proposed to be candidates for the COVID-19 drug by inhibiting the 3CLpro enzyme which plays an important role in the SARS-CoV-2 replication process. Alstonia scholaris has antiviral active compounds but its potential as 3CLpro inhibitor is still unknown. This study aims to examine the potential of bioactive compounds of pulai as an inhibitor 3CLpro (EPI_ISL_576383) by in silico method. Molecular docking performed on 75 test ligands showed that there are eight test ligands that had better binding affinity than JRY7 and two comparison ligands based on the Gibbs free energy, dissociation constant, and interaction with important residue, namely E-16- formyl-5α-methoxystrictamine, 17-O-acetylechitamine, nareline, alschomine, ursolic acid, nareline-methyl-ether, 6-7-seco-angustilobine-B, and picralinal. E-16- formyl-5α-methoxystrictamine is the characteristic compound from Alstonia scholaris which demonstrate the lowest Gibbs free energy and dissociation constant (-6,0350 kcal/mol and 0,0038x104 µM) and has interaction with 11 important residu on the active site of 3CLpro. Keywords: COVID-19, 3CLpro, Alstonia scholaris, in silico
Keyword: COVID-19, 3CLpro, Alstonia scholaris, in silico

Judul: Analisis In Silico Senyawa Aktif Tumbuhan Kayu Manis (Cinnamomum burmannii) sebagai Inhibitor 3C-Like Protease (3CLpro) SARS-CoV-2 di Indonesia
Abstrak: Coronavirus disease 2019 (COVID-19) merupakan penyakit yang disebabkan virus SARS-CoV-2. Senyawa aktivitas antivirus berpotensi dapat menghambat enzim 3CLpro yang berperan dalam proses replikasi SARS-CoV-2. Kayu manis memiliki senyawa aktif antivirus, namun potensinya sebagai inhibitor 3CLpro belum diketahui. Penelitian ini bertujuan menganalisis potensi senyawa aktif kayu manis sebagai inhibitor 3CLpro (EPI_ISL_576383) secara in silico. Penambatan molekuler dengan autodock vina dilakukan terhadap 40 ligan uji menunjukkan sembilan ligan uji memiliki afinitas pengikatan lebih baik dibandingkan dengan JRY1 berdasarkan energi bebas Gibbs, konstanta inhibisi, dan interaksi terhadap residu penting, yaitu benzyl benzoate, caffeic acid, 3- phenylacetate, bornyl acetate, hydrocinnamic acid, eugenol, linalool, α-terpineol, dan 3-phenyl-2-propen-1-ol. Benzyl benzoate merupakan senyawa aktif dengan energi bebas Gibbs dan konstanta inhibisi terendah (-4,5 kkal/mol dan 0,498 µM) yang berinteraksi dengan 10 residu penting di sisi aktif 3CLpro. Linalool dan eugenol merupakan senyawa penciri kayu manis yang memiliki energi bebas Gibbs dan kontanta inhibisi (-3,6 kkal/mol dan 2,281 µM) berinteraksi dengan residu sisi aktif 3CLpro., Coronavirus disease 2019 (COVID-19) is a disease caused by the SARSCoV-2 virus. Compounds with antiviral activity have the potential to inhibit the 3CLpro enzyme which plays a role in the SARS-CoV-2 replication process. Cinnamomun burmannii has antiviral active compounds but its potential as 3CLpro inhibitor is still unknown. This study aimed to analyze the potency of the active compound of cinnamon as an inhibitor 3CLpro (EPI_ISL_576383) by in silico method. Molecular docking with Autodock vina performed on 40 test ligands showed that nine test ligands had better binding affinity than JRY1 based on Gibbs free energy, inhibition constants, and interactions with important residues, namely benzyl benzoate, caffeic acid, 3-phenylacetate, bornyl acetate, hydrocinnamic acid, eugenol, linalool, α-terpineol, and 3-phenyl-2-propen-1-ol. Benzyl benzoate is the active compound with Gibbs free energy and lowest inhibition constant (-4.5 kcal/mol and 0.498 µM) which interacts with 10 important residues on the active site of 3CLpro. Linalool and eugenol are characteristic compounds of Cinnamomum burmannii which have Gibbs free energy and inhibition constants (-3.6 kcal/mol and 2.281 µM) that interact with the residue of active site 3CLpro
Keyword: 3CLpro, Cinnamomum burmannii, In silico, SARS-CoV-2

Judul: Penyebaran Tipe Beranak dan dan Rataan Anak Kambing dilahirkan Pada berbagai Umur Induk, Ulangan Beranak, Frekuensi Beranak serta Nisbah Kelaminnya di Desa Ciburuy dan Cigombong
Abstrak: Penelitian i n i dilakukan pada ternak kambing milik penduduk d i tujuh kampung terbanyak dalam populasi ternak kambing dalam desa Ciburuy dan Cigombong. Penelitian dilakukan selama t i g a belas bulan mulai awal September 1982 sampai akhir September 1983.
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