Judul: Kajian Konflik Lahan di Kawasan Taman Nasional Gunung Leuser (Studi Kasus Desa Lawe Mamas dan Desa Jambur Lak-Lak STPN Wilayah IV Badar BPTN Wilayah II Kutacane, Aceh Tenggara)
Abstrak: Gunung Leuser National Park (TNGL) is one source of life support to accomplish the needs of the community. The rate of significant population growth and development of the cocoa plant that has a high price increase of land use which caused reduced the forest area. On the other hand, managers have an obligation to maintain the forest area in terms of sustainability, as well as the extent of areas which impact on the conflict between forest managers and the people living surrounding the forest. Publication of Act N0 11 of 2006 on Acehnese government actually gives a new color in TNGL management, the establishment of the Leuser Ecosystem Management Agency (BP-KEL), a similar role with the Great Hall of the Gunung Leuser National Park (BBTNGL) makes the administration and coordination becomes difficult. The issue of conflicts in TNGL region is related to forest demarcation, encroachment areas, lack of coordination between agencies, lack of awareness and economic of community around the forest as well as a protracted social conflict. Being conflicts closed 23%, 60% have been sticking surface and 17% had an open conflict. The problem of land conflicts caused by land clearing in 43% cacao tree planting is now being occupied forest villagers. Settlement of land conflicts that occurred in the area TNGL 50% done by mediation, this caused by society is still high to support deliberation and the principle of kinship. In dealing with the conflict parties in involve 76% is the security forces such as military and police was caused influence of social conflicts that occurred in the area of Aceh which took place in a long time.
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Judul: Kajian konflik lahan di kawasan Taman Nasional Gunung Leuser: studi kasus Desa Lawe Mamas dan Desa Jambur Lak-lak STPN wilayah IV Badar BPTN wilayah II Kutacane, Aceh Tenggara
Abstrak: Gunung Leuser National Park (TNGL) is one source of life support to accomplish the needs of the community. The rate of significant population growth and development of the cocoa plant that has a high price increase of land use which caused reduced the forest area. On the other hand, managers have an obligation to maintain the forest area in terms of sustainability, as well as the extent of areas which impact on the conflict between forest managers and the people living surrounding the forest. Publication of Act N0 11 of 2006 on Acehnese government actually gives a new color in TNGL management, the establishment of the Leuser Ecosystem Management Agency (BP-KEL), a similar role with the Great Hall of the Gunung Leuser National Park (BBTNGL) makes the administration and coordination becomes difficult. The issue of conflicts in TNGL region is related to forest demarcation, encroachment areas, lack of coordination between agencies, lack of awareness and economic of community around the forest as well as a protracted social conflict. Being conflicts closed 23%, 60% have been sticking surface and 17% had an open conflict. The problem of land conflicts caused by land clearing in 43% cacao tree planting is now being occupied forest villagers. Settlement of land conflicts that occurred in the area TNGL 50% done by mediation, this caused by society is still high to support deliberation and the principle of kinship. In dealing with the conflict parties in involve 76% is the security forces such as military and police was caused influence of social conflicts that occurred in the area of Aceh which took place in a long time.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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