Judul: Efek nikotin dosis rendah pada mekanisme hambat aterosklerosis monyet ekor panjang (Macaca fascicularis) obes
Abstrak: Obesity is the major risk factor of coronary atherosclerosis, which is a high rank killer among citizen in the world. In order to prevent coronary atherosclerosis, we explored the effect of low dose nicotine liquid peroral using 9 adult males cynomolgous macaques (Macaca fascicularis) obes (body mass indect >23.00) based on celluler histophatological study. These obes monkeys are grouped into 2 groups: one group was given nicotine intervention (n=5) while the other was not (n=4). The evaluation includes the formation of coronary atherosclerotic plague, the cellular aspects of coronary athersclerotic lesions and the present of HDL at the liver and aorta. The correlation analysis revealed a tendency that body mass index and ratio of intimal thickening and coronary arterial wall thickening was correlated. It suggested us that there was also correlation between obesity and severity of atherosclerotic lesion. The novelty of this research included the potential effect of nicotine low dose (1) to protect the smoth muscle cells and endothelial intact, (2) to increase intimal layer regeneration through foam’s cells cytolysis and selluler matrix development, (3) to increase and strenghten smooth muscle cells, and (4) to increase the role of HDL in reverse cholesterol transport. It seems that nicotine has a potencial role to transform atherosclerotic plaque to stabilize artery.
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Judul: Analisis Bobot Badan, Indeks Massa Tubuh, serta Profil Lipid (Total Kolesterol dan HDL) Pada Monyet Ekor Panjang (Macaca fascicularis) dengan Diet Tinggi Lemak dan Intervensi Nikotin.
Abstrak: The aim of this study was to obtain information of body weight, BMI (Body Mass Index), lipid profile especially cholesterol total and HDL cholesterol related to intervention of nicotine. This research consisted of 15 long tailed macaques, divided into three groups based on the types of diet. There were diet type A with energy derived from tallow, diet type B with energy derived from tallow and yolk eggs, and diet type C with commercial diet of Monkey chow. Observation was done before and during the intervention of low dose nicotine with dosage 0.75 mg/kg BB/12 hours per oral. The results of blood lipid analysis showed that there was a significant increase in cholesterol level total during three months of nicotine intervention, especially in group B. However, we found HDL level (P<0.05) was increased in the second month of diet type B and in the third month of diet type A and C. There was no significant decrease in body weight and BMI (P>0.05) during the period of nicotine intervention.
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Judul: Formulasi TSP (Traveling Salesman Problem) menggunakan ILP (Integer Linear Programming)
Abstrak: TSP is a journey of salesman f?om his origin town (place) to visit n-cities (places) only at once, then return to his origin town (place) with a minimum total distance. Its purpose is to minimize the operating expense that is released by the company. Vehicle route at TSP in the form of a Hamiltonian cycle, that is closed path containing all nodes at the graph which representing a network walk. Its problem is to determine a journey route which is feasible (possibly can be passed by) in such a way the vehicle travelled distance passed the route is minimum.
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