Judul: Kajian Konsep Desain Lanskap Jalan Kolonial Kota Bogor.
Abstrak: Bogor City is one of the historic sites in the European colonial era in Indonesia. One of a heritage form in that era is the landscape of colonial. The form of colonial landscape also reflected in the design of street landscape in Bogor City. Study on Design Concept of Colonial Streetscape at Bogor City aims to identify the component of street landscape whose colonial character, exploring the design concept of colonial street landscape, and composing the design concept of street landscape that having colonial character in Bogor. This research has obtained through descriptive analysis by field observation and tracing the information of history. Generally, three main components of colonial street landscape design those are the main elements of street, complementary elements, and colonial building. Complementary elements that characterizing the colonial has the feel of a classic Victorian, gothic and use of industrial materials. The third component of colonial street lanscape is a building that reflects the Dutch colonial era and The important part of it is the facade of the building.
Keyword: colonial concept, street landscape design

Judul: Pengembangan Jalur Wisata Sejarah sebagai Penunjang Wisata Sejarah Kota Bogor
Abstrak: Bogor City have a lot of historical heritage sites from pre-historic period, classic Pajajaran Kingdom period and colonialsm period. The historical landscape is important to be conserved because historical landscape can be visited, learned, examined, or discussed, and become a place at identity, recreation, inspire a spirit, pride, and economics enhancement through tourism. A development planning of historical touring tracks is important to historical tourism development. Tourism tracks function is to facilitate tourists in tourism activities, make it easier for tourist to understand the course of Bogor history, and help to choose a road and visiting object. This study used a survey method with collecting data through desk study, field survey, and interview about location of cultural heritage object and Bogor city tourism situation. As a result, there were 38 among 78 heritage objects those suitable as tourism objects. Determination of 38 cultural heritage objects used an analysis of historical landscape suitable value for tourism object. The proposed historical touring tracks can be accessed from seven access into town that are direction from Ciawi, Sukabumi, Leuwiliang, Parung, Bojong Gede through Stasiun Bogor, Cibinong, and Jakarta trough Jagorawi Toll-Terminal Baranang Siang dan Jagorawi Toll-Bogor Outer Ring Road. There are four proposed tourism programs that is European settlements program, Chinese etnics settlement program, Pajajaran historic sites program, and Moslem settlement and tomb figures program.
Keyword: historical tourism tracks, historical tourism, historical heritage, Bogor City

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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