Judul: Studi Komponen Aktif Temu Lawak terhadap Patogenesis Kanker Kolorektum Jalur Protein Induser dengan Penambatan Molekular
Abstrak: Colorectal cancer is caused by excessive amount of inducible NOS (iNOS) and cyclooxygenase-2 (COX-2) protein in the body. Temu lawak is a plant potential as anticancer. The molecular docking method can be used to determine the activity and efficiency of the temu lawak bioactive compounds, which can inhibit the colorectal cancer through inducer protein iNOS and COX-2 pathway. Based on the molecular docking results of 24 bioactive compounds of temu lawak against 16 proteins in iNOS and COX-2 pathways, the two most potencial anticancer compounds were obtained, demethoxycurcumin and dihydrocurcumin. Both compounds could inhibit colorectal cancer through γ-interferon protein in iNOS pathway and inhibit mitogen activated protein kinase in COX-2 pathway. The experimental parameters used were Gibbs free energy (ΔG), affinity (pKi), inhibition constant (Ki), efficiency, and hydrogen bonding. Based on those parameters, the demethoxycurcumin and dihydrocurcumin were more potencial than simvastatin and rosmaniric acid standards.
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Judul: Studi Komponen Aktif Temu Lawak terhadap Patogenesis Kanker Kolorektum Jalur Protein β-Katenin dengan Penambatan Molekular
Abstrak: Chemotherapy of colorectal cancer can be carried out by inhibiting the activity of excessive β-catenin protein in the body with anticancer compounds. One of the potential plants as anticancer is temu lawak (Curcuma xanthorrhiza). The molecular docking method can be used to determine the potential activity and efficiency of temu lawak bioactive compounds to inhibit the colorectal cancer through β-catenin protein pathway. The docking results of 24 active components in temu lawak against 14 proteins in β-catenin pathway obtained 3 potential bioactive anticancer compounds, namely dihydrocurcumin, demethoxycurcumin, and curcumin. The bioactive compounds could inhibit the colorectal cancer through the axin protein in β-catenin pathway. The interaction were observed based on several parameters: Gibbs free energy (ΔG), affinity (pKi), inhibition constant (Ki), efficiency, and hydrogen bonding. The results from the docking process were better compared with the XAV939 and IWR standards which have been known as inhibitors of colorectal cancer in axin protein.
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Judul: Photosensor producing based on ferroelectric material of Ba0,5Sr0,5TiO3 doped by Ferrium Oxide (Fe2O3) on a P-Type Silicon Substate Si (100) applied as a digital camera with a single pixel image sensor
Abstrak: Thin film Ba0,5Sr0,5TiO3 (BST) doped with Fe2O3 was grown on p-type silicon substrate (100) using chemical solution deposition (CSD). It used the solvent 2-methoxyethanol with annealing temperature of 850°C and the doping treatment Fe2O3 of 2.5, 5, 7.5, 10 % of the mass formed BST. Pure BST had the highest absorption of 600 nm of light wavelength. Additions Fe2O3 moves highest absorption in the range of 560 nm. Fe2O3 addition was strengthening thin film sensitivity to the effects of light. In general, doping Fe2O3 10% was result the best absorbance and current-voltage of BST thin film. Electrical properties of thin films BST include dielectric, photoconductivity, and dissipation energy. Based on the current-voltage (I-V) analysis, pure BST and doped BST showed photodiode properties. Dielectric values obtained in the range from 23.32 to 243. Based on electrical conductivity data and energy dissipation, BST thin films have shown photodiode characteristics and are therefore suitable as light sensors. The image sensor in a digital camera is also a light sensor. This BST thin film has been scientifically proven to be a light sensor and also it can be applied as an image sensor. This is a novelty image sensor based on thin film Ba0.5Sr0.5TiO3.
Keyword: barium strontium titanate, thin film, photodiode, image sensor, digital camera