Judul: FADS gene cluster and FTO gene polymorphisms are associated with obesity and macronutrient intakes in selected Indonesian adults
Abstrak: Obesity prevalence is increasing worldwide, including in Indonesian adults. The fatty acid desaturase gene cluster (FADS1, FADS2, FADS3) and fat mass and obesityassociated (FTO) single nucleotide polymorphism (SNP) rs1421085 have been reported to associate with obesity and macronutrient intake in different populations. This research aimed to investigate the association between obesity and single nucleotide polymorphisms in the FADS1, FADS2, FADS3, and FTO genes in the Indonesian adults. In addition, the study also aimed to investigate the interaction between macronutrient and SNPs in the FADS1, FADS2, FADS3, and FTO genes in influencing obesity in Indonesian adults. A total of 71 subjects (35 obese and 36 non-obese) living in Jakarta, Indonesia, were recruited. The FADS1 rs174547, FADS2 rs174575, and FTO rs1421085 SNPs were detected using amplification-refractory mutation system polymerase chain reaction (ARMS PCR). The FADS3 rs174450 SNP was detected using the DNA sequencing method. Genetic association of the FADS1 rs174547, FADS2 rs174575, FADS3 rs174450, and FTO rs1421085 SNPs with obesity and macronutrient intakes were evaluated using either linear regression or rank-based linear regression analyses depending on the data normality. Minor allele frequencies (MAF) of the FADS1 rs174547, FADS2 rs174575, FADS3 rs174450, and FTO rs1421085 SNPs were 0.32, 0.3, 0.46, and 0.22, respectively. Under the additive genetic model, the subjects who carried the minor T allele of rs174547 SNP were positively associated with increased protein intake (p = 0.009). The subjects with the minor allele of FADS3 rs174450 SNP tended to associate with total protein intake. The subjects who carried the minor C allele of FTO rs1421085 SNP were positively associated with 4.18% increase in fat intake (p = 0.001) and 1.96% increase in saturated fatty acid (SAFA) intake (p = 0.011) in the additive genetic model. The present study indicated that the FADS1 rs174547 SNP minor T allele is associated with the high intake of dietary protein, while the FTO rs1421085 SNP minor C allele was positively associated with high intake of dietary fat, in particular high intake of dietary saturated fatty acid in adults Jakarta, Indonesia. We hope that the findings of this study will provide basic knowledge of the interaction between gene and macronutrients on increasing the obesity risk, particularly in Indonesian adults.
Keyword: Obesity, Macronutrient intake, FTO and FADS gene cluster, polymorphisms, Indonesia.

Judul: Penambatan Molekul Protein Fat Mass And Obesity (Fto) Dengan Senyawa Katekin Dan Turunannya Sebagai Agen Antiobesitas
Abstrak: Obesitas merupakan masalah kesehatan global yang ditandai dengan kelebihan berat badan. Obesitas ternyata dapat disebabkan oleh faktor genetik. Salah satu cara menentukan peran regulasinya secara genetik adalah analisis interaksi molekuler dari protein FTO (Fat Mass and Obesity Associated Protein) yang dikode oleh gen FTO penyebab obesitas. Penelitian ini bertujuan menganalisis lebih lanjut interaksi penambatan molekul protein FTO (4IE6) dengan senyawa katekin dan turunannya pada daerah residu asam amino yang berperan penting dalam penghambatan obesitas. Ligan uji adalah katekin, galokatekin, epikatekin, dan epigalokatekin. Ligan pembanding adalah senyawa orlistat. Hasil yang diperoleh menunjukkan bahwa epigalokatekin memiliki energi bebas Gibbs yang tinggi sebesar -8.0 kkal/mol dan kemiripannya terhadap orlistat mencapai 56 %. Residu asam amino yang paling berperan dalam sisi pengikatan ligan terhadap reseptor adalah Arg-96 dan Arg-322. Berdasarkan penambatan molekul, senyawa katekin dan turunannya memiliki potensi yang baik sebagai antiobesitas melalui mekanisme inhibisi protein FTO.
Keyword: antiobesitas, docking, epigalokatekin, protein FTO

Judul: Penyelesaian Masalah Pelabelan Graf vertex Magic pada Graf Cycle Sederhana
Abstrak: Graf vertex magic adalah suatu graf memiliki nilai bilangan magic yang sama pada masing-masing vertex yang berbeda. Graf cycle sederhana adalah suatu walk tertutup yang mengandung setidaknya tiga vertex, semua vertex-nya berbeda dan setiap vertex terhubungkan oleh satu edge.
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