Judul: The potency of mahogany bark as a lower of blood cholesterol hipercholesterolemia white rats.
Abstrak: Salah satu tumbuhan yang diyakini berkhasiat sebagai tumbuhan obat untuk menurunkan kolesterol darah adalah mahoni (Swietenia macrophylla King.). Penelitian ini bertujuan menguji khasiat ekstrak kulit kayu mahoni sebagai penurun hiperkolesterolemia secara in vivo pada tikus galur Sprague Dawley. Sebanyak 25 ekor tikus jantan dibagi menjadi 5 kelompok (n=5), yaitu kelompok normal (N) diberi pakan standar, kelompok hiperkolesterolemia (HK) diberi pakan kolesterol (1.5%) dan propil tiourasil (PTU) (0.5mg/KgBB), kelompok lovastatin (HK+lovastatin 0.2875 mg/kgBB), kelompok perlakuan ekstrak 1/ E1 (HK+ekstrak air mahoni 150 mg/kgBB), serta kelompok perlakuan ekstrak 2/ E2 (HK+ekstrak air mahoni 300 mg/KgBB). Masa percobaan berlangsung selama 7 minggu, dibagi menjadi 2 periode yaitu peningkatan kolesterol selama 6 minggu dan perlakuan ekstrak kulit kayu mahoni selama 1 minggu. Konsentrasi kolesterol total darah dianalisis setiap 2 minggu dengan metode enzimatik kolesterol oksidase CHOD-PAP (cholesterol oxidase phenol amino phenanzone ) yang diukur dengan spektrofotometer pada panjang gelombang 505 nm. Hasil penelitian menunjukkan pemberian pakan kolesterol (1.5%) dan PTU (0.5 mg/kgBB) selama 7 minggu pada kelompok HK mampu menaikkan konsentrasi kolesterol sebesar 245.50%. Analisis statistik mendukung bahwa kelompok E2 signifikan terhadap kelompok HK dan tidak signifikan terhadap kelompok normal. Sementara dosis ekstrak 150 mg/kgBB tidak berbeda nyata dengan HK. Berdasarkan data dapat disimpulkan bahwa kelompok E2 mampu menurunkan konsentrasi kolesterol.
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Judul: Peroksidasi Lipid pada Tikus Hiperkolesterolemia selama Pemberian Ekstrak Kulit Batang Mahoni (Swietenia macrophylla)
Abstrak: Mahogany’s bark is known as wood industrial waste that contains potential secondary metabolites. However, its potency as an antioxidant, especially in rats which are subjected to hypercholesterolemic treatment, has not been carried out. The aim of this study was to test the effect of mahogany’s water extract consumption on the concentration of lipid peroxides in hypercholesterolemic rats. Thirty five male rats were divided into 5 groups (n=7) namely normal group fed with standard rat chow, hypercholesterolemic group (HK) fed with cholesterol chow (1,5%) and PTU (0,5 mg/KgBW), lovastatin group (HK+lovastatin 0,2857 mg/KgBW), E1 group (HK+ mahogany’s extract 4,2 mg/KgBW), and E2 group (HK+mahogany’s extract 21 mg/KgBW). Experiments were carried out for 8 consecutive weeks. The concentration of lipid peroxides in blood were measured with thiobarbituric acid assay at week 0, 2, 4, 6, and 8 using spectrophotometer. Cholesterol chow (0.86%) and PTU increased the lipid peroxides concentration of HK group by 20.92% compared to the normal group (3.380±0.436 nmol/mL). However, it is not statistically significant (p=0.239). The lipid peroxides concentration in E1 and E2 weren’t increased and relatively similar to normal group at concentration of 2.353±0.196 nmol/mL, 2.786±0.256 nmol/mL, and 2.673±0.279 nmol/mL, respectively. Although it is not statistically significant, both doses of extracts tend to prevent the lipid peroxidation in the rat’s blood.
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Judul: Implementation of Spatio-Temporal Change Query in Relational Database.
Abstrak: Geographic object changes in various views. Object changes are recorded using a model of static storage. No historical connection between old version data and new version data has been built. For that, a storage model of spatio-temporal queries that can analyze spatio-temporal changes has been developed. The object changes the geometry are grouped according to the taxonomy of Spatio-Temporal Pattern Change. This research has been able to apply the query patterns change including born, expand, merge, contract, split, normal and die. This query based on geometric (area) changes. The implementation of spatio-temporal change queries represents an object changes continuously with easy, change detection is done by comparing two versions of data. Keyword: spatio-temporal change query, spatio-temporal change pattern.
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