Judul: Perkembangan Status Pembangunan Kabupaten/Kota di Provinsi Banten Berdasarkan Konsep Pembangunan Berkelanjutan
Abstrak: Sustainable development has been defined as economic and social development that meets the needs of the current generation without undermining the ability of future generations to meet their own needs. Paradigm of sustainable development is a balance of economic grown, social equity and ecology preservation. The purposes of this study were: (1) to study the achievement of social, economic and environmental development indicators, (2) to measure and analyze the differences of social, economic and environmental development, and (3) to determine status of development in 2001, 2005, and 2009 of regencies/cities in Banten Province based on sustainable development conceps. The data was analyzed by using quantitative descriptive, Full Permutation Polygon Synthetic Indicator (FPPSI), Villain and Champbell analysis. FPPSI analysis used 10 (ten) social indicators, 7 (seven) economic indicators and 10 (ten) environmental indicators were selected based on the principles of simplicity, objectivity, scope, quantification, measurement, sensitivity, and time limit. The result showed that the status of development did not increase in urban areas (Tangerang City, Cilegon City) and rural areas (Pandeglang Regency, Lebak Regency, Serang Regency) from 2001 to 2009. Tangerang City and Cilegon City had equitable status in 2001, 2005, and 2009. Pandeglang Regency and Serang Regency had ecology preservation status in 2001, 2005, and 2009 while Lebak had ecology preservation status in 2001 and 2005, but it dropped to unsustainable status in 2009. The status of development that increased only in the peri urban area (Tangerang Regency), it had sustainable development status in 2005, but it decreased to equitable status in 2009 as well as in 2001.
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Judul: Pengembangan Indeks Keberlanjutan Lokal di Provinsi Banten
Abstrak: Provinsi Banten merupakan provinsi paling barat di Pulau Jawa yang lokasinya berbatasan langsung dengan DKI Jakarta sebagai ibukota negara. Pesatnya pembangunan di Jakarta dan Jabodetabek sebagai suatu kawasan metropolitan terbesar di Indonesia telah berdampak luas pada kondisi sosial-ekonomi maupun perkembangan wilayah di sekitarnya. Namun tingginya pertumbuhan ekonomi dan aktivitas pembangunan di kawasan metropolitan tersebut ternyata juga berdampak negatif pada penurunan kualitas lingkungan seperti halnya yang terjadi di Provinsi Banten sebagai salah satu wilayah hinterland-nya. Hal ini tentu dapat mengancam tercapainya pembangunan berkelanjutan di wilayah tersebut. Penelitian ini bertujuan untuk : (1) Mengembangkan indeks keberlanjutan pembangunan di Provinsi Banten pada skala lokal (Local Sustainability Index, LSI) yang ditinjau dari 3 dimensi (dimensi sosial, ekonomi dan lingkungan) serta distribusi sebaran spasialnya, (2) Menganalisis asosiasi spasial nilai local sustainability index (LSI) untuk masing-masing dimensi, dan (3) Menganalisis tipologi wilayah berdasarkan LSI untuk seluruh dimensi. Unit analisis yang digunakan pada pengukuran adalah unit kecamatan. LSI dikembangkan dengan menggunakan metode factor analysis (FA) dengan software statistika. Asosiasi spasial nilai LSI untuk masing-masing dimensi dianalisis menggunakan Global Moran Index dan Local Moran Index atau LISA (Local Indicator of Spatial Autocorrelation) dengan software GeoDa. Sementara itu, tipologi wilayah berdasarkan LSI dianalisis dengan metode gerombol (cluster analysis) dengan software statistika. Hasil penelitian menunjukkan bahwa LSI pada masing-masing dimensi dibentuk dari beberapa nilai penciri. Variabel penciri untuk dimensi sosial dan ekonomi sebanyak 7 variabel, sedangkan variabel penciri untuk dimensi lingkungan sebanyak 5 variabel. Hasil FA tersebut kemudian digunakan untuk menghitung nilai indeks keberlanjutan masing-masing dimensi. Nilai index tertinggi untuk dimensi sosial dan ekonomi terkonsentrasi di Kota Tangerang dan Tangerang Selatan, sedangkan untuk dimensi lingkungan terkonsentrasi di Kabupaten Lebak dan Pandeglang. Nilai global moran index untuk dimensi sosial, ekonomi dan lingkungan secara berturut-turut adalah 0,518895; 0,505767 dan 0,433155, yang berarti bahwa terjadi spatial autocorrelation positif. Hasil analisis cluster menunjukkan bahwa kecamatan-kecamatan di Provinsi Banten terklasifikasi menjadi 3 cluster, dimana cluster 1 adalah kecamatan yang memiliki nilai LSI tinggi untuk dimensi sosial dan ekonomi serta nilai LSI sedang untuk dimensi lingkungan. Cluster 2 adalah kelompok kecamatan dengan nilai LSI rendah baik untuk dimensi sosial, ekonomi dan lingkungan. Cluster 3 adalah kecamatan-kecamatan dengan nilai LSI rendah untuk dimensi sosial dan ekonomi, akan tetapi nilai LSI untuk dimensi lingkungannya tinggi.
Keyword: Analisis cluster, Local Indicator of Spatial Association (LISA), Local Moran Index, Local sustainability index (LSI), Spatial autoccorelation

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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