Judul: Radioprotective Effect of Rosella Extract (Hibiscus sabdariffa L.) against Recurrent Radiodiagnostic Ionizing Radiation: Study of Leukocytes Differentiation in Mice (Mus musculus)
Abstrak: Tujuan penelitian ini adalah untuk mengetahui efek radioprotektif ekstrak tanaman rosela (Hibiscus sabdariffa L.) terhadap radiasi ionisasi radiodiagnostik berulang melalui studi differensiasi sel leukosit darah perifer pada mencit (Mus musculus). Mencit betina sebanyak 48 ekor dibagi kedalam 4 kelompok yaitu: K- (diberi NaCl fisiologis tanpa radiasi), K+ (diberi NaCl fisiologis dengan radiasi), R- (diberi Ekstrak rosela tanpa radiasi), R+ (diberi Ekstrak rosela dengan radiasi). Mencit diberi ekstrak rosela dengan dosis 50 mg/kg berat badan dan NaCl fisiologis dengan volume 0.2 ml/ekor/2 hari sebelum pemaparan radiasi. Radiasi ionisasi dilakukan dengan dosis 0,2 mSv/paparan/2 hari selama 4 & 8 minggu pada berkas sinar utama. Pengambilan darah perifer dilakukan pada setiap kelompok pada minggu ke-0 (sebelum perlakuan), 2, 4, 6 & 8. Pengambilan data pemulihan selama 30 hari setelah minggu 4 dan 8 tanpa paparan radiasi. Hasil penelitian menunjukkan paparan radiasi dapat meningkatkan persentase netrofil band meningkat, netrofil adult, migrasi limfoblas, dan mieloblas serta menurunkan persentase monosit dan limfosit pada jaringan darah perifer. Pemberian ekstrak rosela dapat meningkatkan persentase limfosit dan monosit serta menurunkan persentase netrofil band, netrofil adult, limfoblas, dan mieloblas. Dari hasil penelitian didapatkan bahwa ekstrak tanaman rosela (Hibibscus sabdariffa L.) memiliki efek radioprotektif terhadap radiodiagnostik berulang pada sel leukosit darah perifer mencit (Mus musculus)
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Judul: Efek Radioprotektif Ekstrak Rosela (Hibiscus sabdariffa L.) terhadap Radiasi Ionisasi Radiodiagnostik Berulang: Studi Gambaran Eritrosit Darah Perifer Mencit (Mus musculus).
Abstrak: The aim of this study was to determine the radioprotective effect of ethanolic roselle extract (Hibiscus sabdariffa L.) in recurrent radiodiagnostic ionizing radiation on peripheral red blood cells of mice (Mus musculus). Fourty eight male mice were used in this study and divided into 4 group; K-(physiological saline without radiation), K+ (physiological saline with radiation), R- (roselle extract without radiation), R+ (roselle extract with radiation). The mice were treated with 50 mg per kg body weight ethanolic roselle extract prior to radiation exposure. Following these treatment, the mice were exposed with ionizing radiation at dose 0.2 mSv every two days for 8 weeks. Bloods sample were collected of each group at week 0 before treatment, 2, 4, 6, and 8 week after treatment. The blood samples were taken also at 4 and 8 week, which previously without radiation exposure for 30 days as recovery phase. The result showed that radiation exposure causes an increasing the number of Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC) and Howell Jolly Bodies in the peripheral blood tissue. However ethanolic roselle extract causes a decreasing number of the parameters. This result indicated that ethanolic roselle extract has radioprotective effect on of red blood cells repair process from ionizing radiation destruction (p<0.05).
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Judul: Basis of Social Theories for Social Enterprises: Integrative Literature Review
Abstrak: Social enterprise is a hybrid organization aiming to achieve economic and social values that exist as an effective mechanism for creating value in the form of society, economy and environment. The development of social enterprise is considered to have contributed in increasing innovation as well as being a mechanism for ensuring economic development that is in line with social justice. However, the development of theory and study of social enterprise is still lagging behind in practice. The social enterprise conception is a conception that is still considered as a "young term" category in the social sciences and has not shown clear consistency linking social theories to the development of social enterprise. This study aims to identify the basic theories of social enterprise and social theories for social enterprise with used an integrated literature review approach with data sources from Scopus and ProQuest. The results of the study found that socio-economic theory is the basis for social enterprise theory. This study also found the linkages of 7 social theories for social enterprise and the mapping of social theory architecture for social enterprise which is studied on classical and contemporary social theories.
Keyword: integrative literature review, social economic, social enterprise, social theory