Judul: Urbanisasi dan dampaknya terhadap lingkungan pemukiman di Kodya Ujung Pandang, Propinsi Sulawesi Sealatan
Abstrak: Di Sulawesi Selatan, khu.susnya di Kotamadya Ujung Pandang proses urbanisasi desa-kota telah lama terjadi dengan motivasi dan tujuan yang relatif sama, menghindari keadaan yang tidak menguntungkan di daerah asalnya dan pindah ke kota untu.k mencari penghidupan yang lebih sejahtera dan lebih aman. Pendatang di Kotamadya Ujung Pandang yang menjadi obyek penelitian, dibagi atas tiga kelompok masing-masing kelompok pendatang menetap, kelompok pendatang musiman dan kelompok pelaju (9.9.mnmter), sedangkan kelompok penduduk asli dijadikan kelompok pembanding. Penentuan desa/Kelurahan contoh dilakukan secara purposif di antara beberapa desa/kelurahan di wilayah Kotamadya Ujung Pandang. Dalam hal ini dipilihsembilan desa/kelurahan yang merupakan lokasi penelitian, sedang pemilihan pendatang dan penduduk asli sebagai contoh dipakai metode rendom sammpling. ...
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Judul: Urbanisasi dan Dampaknya Terhadap Lingkungan Pemukiman di Kotamadya Ujung Pandang Propinsi Sulawesi Selatan
Abstrak: Di Sulawesi Selatan, khususnya di Kotamadya ujung Pandang proses urbanisasi desa-ko ta telah lama terjadi dengan motivasi dan tujuan yang relatif sama, menghindari keadaan yang tidak menguntungkan di daerah asalnya dan pindah ke kota untuk mencari penghidupan yang lebih sejahtera dan lebih aman.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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