Judul: Dampak Dinamika Perubahan Tutupan Lahan
Terhadap Suhu Udara di Kota dan Kabupaten Bogor
Abstrak: The very rapid development of a city results in changes in land use, which results in many changes in non-built land turning into built-up land such as the rapid and unplanned development of physical infrastructure that reduces the distribution of vegetation. This study aims to identify changes in land cover and their impact on temperature. air in the Bogor City and Regency of Bogor. Changes in land cover in Bogor City were dominated by land changes, tree vegetation decreased by 16.99% to mixed vegetation, increased to 7.04% and built-up land increased by 10.6%, while the class of water bodies decreased by only 0.65%. The impact of land cover changes in Regency of Bogor is still lower than Bogor City, because land cover dominated by tree and non-tree vegetation is still widely found and does not have significant changes when compared to Bogor City which has a large amount of built-up land cover compared to tree and non-tree vegetation.
Keyword: air temperature, change, land cover

Judul: Dampak Dinamika Perubahan Tutupan Lahan Terhadap Suhu Udara di Kota dan Kabupaten Bogor
Abstrak: Perkembangan suatu kota yang sangat pesat mengakibatkan terjadinya perubahan dalam penggunaan lahan, yang mengakibatkan banyaknya perubahan pada lahan non terbangun beralih menjadi lahan terbangun seperti pembangunan infrastruktur fisik yang pesat dan tidak terencana membuat berkurangnya sebaran vegetasi. Penelitian ini bertujuan mengidentifikasi perubahan tutupan lahan dan dampaknya terhadap suhu udara di Kota Bogor dan Kabupaten Bogor. Perubahan tutupan lahan di Kota Bogor didominasi perubahan lahan vegetasi pohon berkurang berkisar 16,99% menjadi menjadi lahan bervegetasi campuran bertambah menjadi 7,04% dan lahan terbangun bertambah 10,6%, sementara kelas badan air mengalami penurunan hanya 0,65%. Dampak dari perubahan tutupan lahan terhadap suhu udara di Kabupaten Bogor masih lebih rendah dibandingkan Kota Bogor, karena tutupan lahan yang didominasi vegetasi pohon dan non pohon masih banyak ditemukan dan tidak memiliki perubahan yang signifikan jika dibandingkan dengan Kota Bogor yang memiliki jumlah tutupan lahan terbangun yang luas jika dibandingkan dengan vegetasi pohon dan non pohon., The very rapid development of a city results in changes in land use, which results in many changes in non-built land turning into built-up land such as the rapid and unplanned development of physical infrastructure that reduces the distribution of vegetation. This study aims to identify changes in land cover and their impact on temperature. air in the Bogor City and Regency of Bogor. Changes in land cover in Bogor City were dominated by land changes, tree vegetation decreased by 16.99% to mixed vegetation, increased to 7.04% and built-up land increased by 10.6%, while the class of water bodies decreased by only 0.65%. The impact of land cover changes in Regency of Bogor is still lower than Bogor City, because land cover dominated by tree and non-tree vegetation is still widely found and does not have significant changes when compared to Bogor City which has a large amount of built-up land cover compared to tree and non-tree vegetation.
Keyword: air temperature, change, land cover

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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