Judul: Penambatan Molekuler Xantin Oksidase oleh Senyawa Aktif Sirih Merah (Piper crocatum) sebagai Pengobatan Alternatif Asam Urat
Abstrak: Produksi asam urat berlebih di dalam tubuh dapat mengendap di persendian dan menimbulkan rasa nyeri dan kaku sehingga sendi mengalami pembengkakan. Penghambatan enzim xantin oksidase diketahui mampu menjadi jalan terapi dalam menghambat produksi asam urat. Penelitian ini bertujuan mengidentifikasi interaksi molekuler xantin oksidase oleh senyawa aktif sirih merah yang berpotensi dalam menghambat aktivitas enzim xantin oksidase sebagai pengobatan alternatif asam urat. Penelitian dilakukan dengan metode in silico yaitu penambatan terarah (site directed docking). Ukuran pusat penambatan yang digunakan dalam penelitian ini sebesar x=26,7853; y= 9,9800; z= 113,3917 dengan nilai dimensi x=14 ; y=14 ; z=18. Potensi inhibisi terbaik dimiliki oleh sofalkon, asam protokatekuat, dan 2-(3,4-dimetoksi fenil)-6-etoksi-7- metoksi-1-naftol dengan nilai ∆G dan Ki yang lebih baik dibanding allopurinol serta memiliki interaksi residu yang cukup kuat terhadap sisi aktif xantin oksidase, Excess uric acid production in the body can settle in the joints and cause pain and stiffness si that the joints experience swelling. Inhibitoin of the xanthine oxidase enzym is known to be abe to be a therapeuticroute in inhibiting uric acid production. This research aims to identify the molecular interactions of xanthine oxidase by red betel compounds which had the potential to inhibit the activity of xanthine oxidase enzyme as an alternative treatment for gout. The research was conducted using in silico method by site-directed docking. The size of the center retardation used in this research was x= 26,7853; y= 9,9800; z= 113,3917 with dimension value x= 14; y= 14; z= 18. The best inhibition potential was sofalcone, protocatechuic acid, and 2-(3,4-dimethoxy phenyl)-6-ethoxy-7- methoxy-1-naphtol with better ∆G and Ki values than allopurinol and had a fairly strong residual interaction with the active site of xanthine oxidase.
Keyword: molecular docking, red betel, uric acid, xanthine oxidase

Judul: Kajian Potensi Beberapa Ekstrak Tanaman Herbal sebagai Anti Asam Urat dan Aktivitas Inhibisinya terhadap Xantina Oksidase
Abstrak: Artritis gout (asam urat) adalah penyakit gangguan sendi. Pencegahan gout dapat dilakukan dengan cara memberikan obat-obatan yang bekerja langsung pada enzim yang berperan meningkatkan kadar asam urat yaitu xantina oksidase. Penghambatan xantina oksidase terjadi oleh alopurinol. Penelitian bertujuan meninjau berbagai tulisan mengenai potensi beberapa ekstrak tanaman herbal sebagai inhibisi terhadap xantina oksidase untuk mengetahui potensinya sebagai anti gout (asam urat). Metode yang digunakan adalah menelaah pustaka primer berbagai tulisan, berupa jurnal, berita, makalah, skripsi, tesis, dan disertasi. Hasil penelitian menunjukan terdapat beberapa tanaman herbal yang memiliki senyawa aktif seperti flavonoid yang mampu menjadi inhibitor bagi xantina oksidase. Tanaman tersebut di antaranya, sidaguri, tempuyung, daun salam, daun alpukat, daun jarum tujuh bilah, dan keladi candik. Tanaman-tanaman tersebut memiliki potensi yang baik dalam menghambat xantina oksidase. Hal ini dapat dilihat dari nilai aktivitas inhibisinya yang lebih tinggi dari alopurinol, Gout artritis (uric acid) is a disease of joint disorders. Prevention of gout can be done by giving drugs that work directly on enzymes that play a role in increasing uric acid levels, is xanthine oxidase. Allopurinol is inhibited by xanthine oxidase. This study aims to review various articles on the potential of several herbal plant extracts as xanthine oxidase inhibitors to determine their potential as anti-gout. The method used is a literature review for the primary literature of various kinds of writings, in the form of journa ls, news, papers, theses, and dissertations. The results showed that there were several herbal plants that had active compounds such as flavonoids which were able to become inhibitors of xanthine oxidase. These plants include sidaguri, tempuyung, bay leaves, avocado leaves, jarum tujuh bilah leaves, and keladi taro. These plants have good potential in inhibiting xanthine oxidase. This can be seen from the value of its inhibitory activity which is better than alopurinol.
Keyword: gout, alopurinol, herbal plants, inhibition.

Judul: Klasifikasi genre musik menggunakan Learning Vector Quantization (LVQ)
Abstrak: Radio stations and music television have a milion of music tapes. A lot of musical genres create a problem when people wants to determine the right genre of a new kind of music. To classify the musical genre is not an easy task, because the musical genre is really difficult to standardization. Automatic musical genre classification can assist the human role in that process and help people to searching for the song acording to the genre that people want. This research using Mel Frequency Coefficient Cepstrum (MFCC) to obtain feature extraction. Learning Vector Quantization (LVQ), one kind of artificial neural network used for classification method. The number of genres that are used were four kind of musical genre, that is rock, classic, keroncong, and jazz with four different duration that is 5 second, 10 second, 20 second and 25 second. This research using k- fold cross validation to distribute dataset for training and testing set with the number of folds as much as 2 until 10 fold. This research succesfully implemented MFCC feature exraction and classification using LVQ. Based on this research, the accuracy of the classification using Learning Vector Quantization reaches 93,75% for the four type musical genre. The highest accuracy value was obtain from the experiments with a duration of 10 second and the number of fold 4. Training time for each duration is 30 minute for 5 second music duration, 45 minute for 10 second music duration 120 minute for 20 second music duration and 150 minute for 25 second music duration.
Keyword: