Judul: Uji aktivitas hepatoprotektor ekstrak air pegagan (Centella asiatica) terhadap tikus putih jantan yang diinduksi parasetamol
Abstrak: This study was undertaken to investigate activity of Centella asiatica extract against paracetamol induced liver damage in male Wistar albino rats. Rats were divided into five groups namely control (aquadest), herb extract with four formulations which were F 6, F 10, F 12, and F 16. Rats were administered paracetamol at dose 1000 mg/kg bw (p.o) as toxic dose for inducing hepatotoxicity. Herb extract in each formula was given at dose 1500 mg/kg bw (p.o) one hour after paracetamol administration. The treatment was given for eight days and blood was collected three times (before treatment, after paracetamol treatment, and last treatment) from tail artery and analysed for serum glutamate pyruvate transminase (SGPT). The hepatoxicity produced by acute paracetamol administration was found to be inhibited by Centella asiatica at group F 16 with evidence of decreased level of serum glutamate pyruvate transminase (SGPT) consentration. The hepatoprotective activity Centella asiatica was also supported by histopathological studies of hepatocytes
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Judul: Aktivitas hepatoprotektor ekstrak metanol daun kari (Murraya koenigii .L.) pada tikus putih Sprague dawley, Activity of Curry Leaf (Muraya koenigii. L.) Methanol Extract as Hepatoprotector in Sprague dawley Rats
Abstrak: Curry leaf is being thought as hepatoprotector againts liver damage caused by hepatotoxic agent such as paracetamol. This study was assesing the activity of curry leaf extract in reducing the activity of ALT (alanine aminotransferase) and AST (aspartate aminotransferase) in rats were given high dose paracetamol. Total of 25 rats were used in this research which were divided into 5 experimental groups as follows: normal control group (N), negative control group (KN) (paracetamol dose 500 mg/Kg BW were given 21 days), positive control group (KP) (curliv dose 42.86 mg/Kg BW were given 21 days), dose 200 mg/Kg BW extract group (ED200), and dose 300 mg/Kg BW extract group (ED300). Extracts were given 7 days before paracetamol treatment and continous until end of experiment. Pytochemistry test results showed that curry leaf methanol extract contain alcaloids, tannins, saponins, and steroids. Extract group had not significantly reduced ALT and AST activity (p>0.05) compared to N group. Decreasing ALT and AST activity in ED200 group is 16.21% and 33.82%. Decreasing ALT and AST activity in ED300 group is 33.82% dan 62.60%. Methanol extract curry leaf had hepatoprotector activity although not significantly differences.
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Judul: Construction of Strongly Optimal Binary Linear Code with Minimum Distance 9 and 11
Abstrak: A binary linear code of length n over q F is a subspace of n q F . A code has three parameters that attached to it, namely length, dimension, and minimum distance. A code with length n, dimension k and minimum distance d is often called [n, k, d ]-code. Usually, when two parameters are given, then we want to find a code that has the best value for the last parameter. Based on Gilbert- Varshamov bound, if a [n, k, d ]-code exists and can not be expanded, we call it a strongly optimal code. In this paper, we construct strongly optimal code with minimum distance 9 and 11. In constructing the code, we created a theorem and algorithm based on Gilbert-Varshamov bound before we implement the algorithm to MAPLE programming language. Because of computational limitations, the program can only construct up to k = 10 for d = 9 and k = 12 for d = 11.
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