Judul: Analisis daya dukung lahan serta faktor-faktor lingkungan yang mempengaruhinya pada kawasan DAS Tiworo Kabupaten MUM, Sulawesi Tenggara
Abstrak: Lahan merupakan salah satu sumberdaya alam fisik yang mempunyai peranan penting seperti untuk pemukiman, tempat bangunan fasilitas sosial, pertanian, peternakan, kehutanan, pertambangan dan jaringan jalan. Ketersediaan lahan terutama untuk kegiatan pertanian dari tahun ketahun semakin terbatas seiring dengan pertambahan jumlah penduduk sehingga perlu pagelolaan yang baik agar lahan mampu menyokong kehidupan masyarakat setempat. Namun terkadang akibat dari pengelolaan pertanian yang orang baik sehingga daya dukung lahan pada kawasan tersebut menjadi rendah.
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Judul: Analisis daya dukung lingkungan berdasarkan optimalisasi penggunaan sumberdaya lahan di bagian Hulu Daerah Aliran Sungai Way Seputih Lampung Tengah
Abstrak: Ditinjau dari segi ekologi, DAS (Daerah Aliran Sungai) merupakan suatu ekosistem dengan komponen-komponennya tanah, air, flora, fauna, serta manusia dengan semua aktivitasnya. Pertumbuhan penduduk yang pesat dan pembangunan yang dilakukan oleh berbagai sektor tanpa asas-asas pelestarian disuatu DAS akan mengakibatkan kerusakan sumberdaya alam dan lingkungan, yang pada akhirnya akan menurunkan daya dukung lingkungan .
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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