Judul: Socio-Cultural Transformations Orang  Rimba in Utilization of Biodiversity in Bukit Duabelas National Park, Jambi
Abstrak: Transmigrasi merupakan program pemerintah dalam upaya pemerataan penduduk yang salah satu lokasinya berada di wilayah jelajah Orang Rimba, sehingga mengalihkan fungsi hutan menjadi permukiman transmigran. Transmigrasi menyebabkan perubahan pada sistem penghidupan Orang Rimba yang mendorong terjadinya transformasi sosial budaya. Penelitian ini bertujuan mendeskripsikan transformasi sosial budaya Orang Rimba dalam pemanfaatan biodiversitas dan menentukan faktor penentu transformasi sosial budaya Orang Rimba. Pengumpulan data dilakukan melalui studi pustaka, observasi, dan wawancara kepada 30 responden laki-laki yang sudah menikah. Berdasarkan unsur kebudayaan yang ditinjau terjadi transformasi sosial budaya yang berdampak pada pemanfaatan biodiversitas seperti berkurangnya pemanfaatan tumbuhan untuk keperluan adat, menurunnya pemanfaatan satwa, menurunnya pemanfaatan terhadap spesies yang bahasa lokalnya sudah tidak dikenali, menurunnya pengetahuan dan pemanfaatan biodiversitas untuk obat, pemanfaatan hanya pada spesies bernilai ekonomis, frekuensi pemanfaatan biodiversitas semakin tinggi karena peralatan semakin canggih, dan menurunnya intensitas pemanfaatan biodiversitas sebagai kerajinan tangan. Faktor penentu transformasi sosial budaya Orang Rimba adalah ketidakpuasan, perubahan kondisi fisik lingkungan, dan interaksi budaya lain.
Keyword: Orang Rimba, socio-cultural transformation, utilization of biodiversity

Judul: Social Capital and Welfare of Orang Rimba in Bukit Duabelas National Park Jambi Province
Abstrak: The population of the Orang Rimba continues to grow, resulting in an increase in the fulfillment of life needs and changes in forest utilization patterns. These changes are related to the social capital of the Orang Rimba and have an impact on the level of social welfare. This study aimed to identify the elements of social capital and social welfare of Orang Rimba inner and outer, compare the social capital and social welfare of Orang Rimba inner and outer of Bukit Duabelas National Park, and identify the relationship between social capital and social welfare of Orang Rimba. Data collection was conducted by interview and observation in both locations. The results showed that the elements of trust, social networks, social norms, proactive action, and caring did not significantly differ between the Orang Rimba in the two locations. In contrast, there was a significant difference in social welfare, whereas the social welfare of the Orang Rimba inside Bukit Duabelas National Park was higher than that of Orang Rimba outside Bukit Duabelas National Park. Social capital and social welfare tended to show a negative relationship., Populasi Orang Rimba terus bertambah dan mengakibatkan terjadinya peningkatan pemenuhan kebutuhan hidup serta perubahan pola pemanfaatan hutan. Perubahan ini berhubungan dengan modal sosial Orang Rimba dan berdampak pada tingkat kesejahteraan sosial. Penelitian ini bertujuan mengidentifikasi unsur modal sosial dan kesejahteraan sosial Orang Rimba dalam dan luar, membandingkan modal sosial dan kesejahteraan sosial Orang Rimba dalam dan luar Taman Nasional Bukit Duabelas serta mengidentifikasi hubungan antara modal sosial dan kesejahteraan sosial Orang Rimba. Pengumpulan data dilakukan dengan wawancara dan observasi di kedua lokasi. Hasil penelitian menunjukkan unsur kepercayaan, jaringan sosial, norma sosial, tindakan proaktif, dan kepedulian tidak memiliki perbedaan yang nyata antara Orang Rimba di kedua lokasi. Sebaliknya, terdapat perbedaan yang nyata pada kesejahteraan sosial yaitu kesejahteraan sosial Orang Rimba dalam Taman Nasional Bukit Duabelas lebih tinggi dibandingkan Orang Rimba luar Taman Nasional Bukit Duabelas. Modal sosial yang dihubungkan dengan kesejahteraan sosial cenderung menunjukkan hubungan yang negatif.
Keyword: Orang Rimba, social capital, social welfare

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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