Judul: Aktivitas antijerawat formula campuran meniran dan temu lawak serta aktivitas inhibisinya terhadap katalase Staphylococcus aureus
Abstrak: Acne is an inflammation of skin caused by Staphylococcus aureus, S. epidermidis, and Propionibacterium acnes bacteria. Antiacne activity of temu lawak and meniran has been analyzed through antibacterial activities against S. aureus and S. epidermidis and inhibition of S. aureus catalase activity. Temu lawak and meniran were extracted by using maceration technique in 96% ethanol with two different maceration methods, Indonesian and traditional chinese medicine. S. aureus and S. epidermidis were successfully isolated. The growth of S. aureus was inhibited by temu lawak extract with minimum bactericidal concentration (MBC) 150 ppm and inhibition zone index 0.38. The growth of S. epidermidis was inhibited by mixture of temu lawak 2/3 and meniran 1/6 with MBC 300 ppm and inhibition zone index 0.40. Thin layer chromatography profile of both extracts showed curcuminoid band. Catalase enzyme was successfully isolated from S. aureus. Mixture of temulawak 2/3 and meniran 1/6 gave the best catalase inhibition activity, 6.88% in 500 ppm formula concentration.
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Judul: Mixture Formula Temulawak (Curcuma xanthorriza) and Meniran (Phyllanthus niruri) Extract as Antiacne.
Abstrak: Penelitian ini bertujuan menguji efektivitas campuran ekstrak temulawak (Curcuma xantorrizha) dan meniran (Phyllanthus niruri) sebagai antijerawat dibandingkan masing-masing ekstrak, terutama dilihat dari aktivitasnya sebagai antibakteri terhadap Staphyllococcus epidermidis dan antioksidan. Rimpang temulawak dan meniran diekstraksi dengan etanol 96%. Selanjutnya ekstrak tersebut dibuat formula campurannya berdasarkan rancangan simplex centroid. Kesepuluh formula yang diperoleh diuji aktivitasnya sebagai antioksidan dan antibakteri. Formula 5 (½ temulawak dan ½ meniran) merupakan formula teraktif sebagai antijerawat dengan nilai IC50 untuk antioksidan sebesar 9.47 ppm, konsentrasi hambat minimum (KHM) untuk S.epidermidis sebesar 0.25 mg/mL, dan konsentrasi bunuh minimum (KBM) sebesar 1.00 mg/mL. Setelah dianalisis penciri dengan kromatografi lapis tipis (KLT) dan kromatografi cair kinerja tinggi (KCKT), diketahui bahwa dalam formula 5 terdapat senyawa xantorizol, filantin, dan hipofilantin.
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Judul: Construction of Strongly Optimal Binary Linear Code with Minimum Distance 9 and 11
Abstrak: A binary linear code of length n over q F is a subspace of n q F . A code has three parameters that attached to it, namely length, dimension, and minimum distance. A code with length n, dimension k and minimum distance d is often called [n, k, d ]-code. Usually, when two parameters are given, then we want to find a code that has the best value for the last parameter. Based on Gilbert- Varshamov bound, if a [n, k, d ]-code exists and can not be expanded, we call it a strongly optimal code. In this paper, we construct strongly optimal code with minimum distance 9 and 11. In constructing the code, we created a theorem and algorithm based on Gilbert-Varshamov bound before we implement the algorithm to MAPLE programming language. Because of computational limitations, the program can only construct up to k = 10 for d = 9 and k = 12 for d = 11.
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