Judul: Efek Pemberian Teripang Pasir (Holothuria scabra J) terhadap Profil Imunohistokimia Antioksidan Dismutase (SOD) pada Pankreas Tikus Diabetes
Abstrak: The aim of this research is to analyse the effect of sea cucumber (Holothuria scabra J) on the profile of antioxidant enzymes copper,zinc-superoxide dismutase (Cu,Zn-SOD) in the pancreatic of diabetes mellitus rats. A total of 25 male white rats (Sprague Dawley) were used for this study. They were divided into five groups; (1) negative control (KN), (2) positive control, rats with diabetes mellitus (KP), (3) diabetic rats treated with sea cucumber protein hydrolyzate (HDL), (4) diabetic rats treated with sea cucumber protein concentrated (KST), (5) diabetic rats treated with sea cucumber protein isolate (ISL). Diabetic condition conducted by alloxan injection with doses 110 mg/kg bb. Pancreatic β cells will be damaged by alloxan, then the insulin secretion will decrease. The treatment were done for 28 days. The pancreatic tissue were obtained after treatment ends. Pancreatic tissue were fixed with Bouin solution and then processed into histological preparations. The tissue were then stained with immunohistochemical staining techniques using monoclonal antibody of Cu,Zn-SOD. The results showed that treatment of HDL, KST, and ISL sea cucumber (Holothuria scabra J) increased content antioxidant Cu,Zn-SOD in pancreatic tissue. The HDL treatment gave the best effect in increasing the antioxidant content of Cu,Zn-SOD in pancreatic tissue of diabetic rats.
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Judul: Efek Pemberian Ekstrak Etanol Biji Mahoni Terhadap Profil Imunohistokimia Antioksidan Superoksida Dismutase (Sod) Pada Pankreas Tikus Model Diabetes
Abstrak: Penelitian ini bertujuan untuk menganalisis efek ekstrak etanol biji mahoni terhadap berat badan, kadar glukosa darah dan profil antioksidan copper, zinc-superoxide dismutase (Cu,Zn-SOD) jaringan pankreas tikus DM. Sejumlah 25 ekor tikus jantan putih galur Sprague Dawley telah digunakan pada penelitian ini, yang dibagi menjadi lima kelompok perlakuan, yaitu : (1) Kontrol negatif (KN), (2) Kontrol positif, tikus DM (KP), (3) Tikus DM yang diberi ekstrak etanol biji magoni (EM), (4) Tikus DM yang diberi obat acarbose 2 mg/Kg berat badan. dan (5) Tikus non DM yang diberi ekstrak etanol biji magoni (KE). Kondisi DM didapatkan dengan induksi alloxan 110 mg/kg bb pada tikus percobaan. Perlakuan ekstrak etanol biji mahoni dilakukan selama 28 hari. Berat badan, total konsumsi pakan, dan kadar glukosa darah dihitung selama masa perlakuan. Pada akhir perlakuan, tikus dianestesi dengan ketamine-xylazine dan organ pankreas diambil. Organ pankreas selanjutnya difiksasi dengan larutan Bouin, kemudian diproses dengan diembedding menggunakan parafin. Potongan jaringan selanjutnya diwarnai secara imunohistokimia menggunakan antibodi monoklonal Cu,Zn-SOD. Hasil yang diperoleh menunjukan bahwa ekstrak etanol biji mahoni mampu meningkatkan berat badan, menurunkan konsumsi pakan dan kadar glukosa darah, serta mempertahankan kandungan antioksidan Cu, Zn-SOD baik di pulau Langerhans maupun di sel-sel asinar jaringan pankreas tikus DM.
Keyword: antioksidan Cu, Zn-SOD, diabetes melitus, imunohistokimia, pankreas, mahoni

Judul: Construction of Strongly Optimal Binary Linear Code with Minimum Distance 9 and 11
Abstrak: A binary linear code of length n over q F is a subspace of n q F . A code has three parameters that attached to it, namely length, dimension, and minimum distance. A code with length n, dimension k and minimum distance d is often called [n, k, d ]-code. Usually, when two parameters are given, then we want to find a code that has the best value for the last parameter. Based on Gilbert- Varshamov bound, if a [n, k, d ]-code exists and can not be expanded, we call it a strongly optimal code. In this paper, we construct strongly optimal code with minimum distance 9 and 11. In constructing the code, we created a theorem and algorithm based on Gilbert-Varshamov bound before we implement the algorithm to MAPLE programming language. Because of computational limitations, the program can only construct up to k = 10 for d = 9 and k = 12 for d = 11.
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