Judul: Penerapan Metode Dua Tahap Dalam Penggerombolan Data Berskala Campuran (Studi Kasus: Potensi Desa di Provinsi Jawa Barat pada Tahun 2011)
Abstrak: Umumnya metode penggerombolan mengasumsikan data memiliki skala numerik saja atau kategorik saja. Namun pada kenyataan, sering didapatkan data berskala campuran, yaitu memiliki skala kategorik dan juga numerik. Jenis data berskala campuran apabila diterapkan metode penggerombolan klasik menjadi kurang efektif. Salah satu alternatif yang dapat digunakan dalam penanganan data berskala campuran, yaitu dengan pendekatan metode dua tahap. Pendekatan ini merupakan analisis gerombol dua tahap untuk menggerombolkan data yang memiliki peubah campuran. Tahapan dalam pendekatan ini ialah mengubah peubah kategorik menjadi peubah numerik sehingga penerapan analisis gerombol berskala numerik dapat diterapkan. Berdasarkan hasil pengerombolan pada data Podes 2011 wilayah Jawa Barat dihasilkan 2 gerombol sebagai gerombol akhir, yaitu gerombol perkotaan dan gerombol perdesaan. Peubah yang menjadi ciri pada gerombol perkotaan ialah Peubah Jumlah Penduduk, Kepadatan Penduduk, dan Peubah Jumlah Minimarket. Sedangkan peubah yang menjadi ciri pada gerombol perdesaan ialah Peubah Sumber Penghasilan Utama berupa pertanian, tidak adanya pertokoan atau Peubah Pertokoan, dan tidak adanya Bank Umum atau Peubah Bank Umum.
Keyword: clutering analysis, mixed scale data, two-step method

Judul: Penerapan Metodetwo Step Cluster Dalam  Analisis Gerombol  (Studi Kasus : Data Potensi Desa Sensus Ekonomi 2003 Wilayah Jawa Barat)
Abstrak: Clustering is a process of grouping objects based on similarities . Some problems in cluster analysis are the different scale of measurement, large data sets and unspecified number of cluster. One approach to handle this problems is by using Two Step cluster method. The purpose of this research is to applicate Two Step cluster method by clustering villages residing in West Java. The result of Two Step cluster method are pre-cluster which early yielded at first phase counted eight clusters and optimal cluster which yielded at second phase counted three clusters. Members in first cluster are objects which is extreme outliers and cannot be grouped into other clusters. Villages which include into second clusters have rural characteristic. The village has wide farm, many agriculture households, but also has underdeveloped field of industries and also information and communications. So that, to improve village potency for this cluster, the variables which still have low growth level has to be increased. The third cluster has the characteristic of urban status. Village in this cluster has the closest distance to downtown, developed enough in the field of industry, information and communications, but still have the highest number for unemployment citizens.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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