Judul: Pengaruh Nikotin pada Gambaran Mikroskopis Pankreas Monyet Ekor Panjang (Macaca fascicularis) yang Diberi Pakan Berenergi Tinggi
Abstrak: Nicotine, in a low dosage, is expected to be used for health problems therapy such as obesity, hypertension, diabetes, heart disease, and other metabolic syndrome diseases. The aim of this study was to evaluate the microscopic changes of the pancreas in long tailed macaque which fed a high-energy diet with an oral intervention of nicotine. Twelve monkeys were devided into two groups based on nicotine and non nicotine treatment. Group with nicotine consisted of ten monkeys were further divided into two groups based on the type of diet. Each group consisted of five monkeys. The main content of diet A was tallow and diet B was commercial feed (monkey chow). Liquid nicotine intervention with a dosage of 0.75 mg/kg body weight were given every twelve hours for three months on both groups. While the non nicotine treatment was a negative control consisted of two monkeys were given diet B. All monkeys were under went to be euthanized by initially anesthetizing using ketamine HCl 10 mg/kg, intramuscularly. Microscopic samples were prepared based on the three pancreatic areas, caput, corpus, and cauda. They were stained with haematoxylin-eosin (HE) for standard staining, and Congo red to evaluated amyloid accumulation on the pancreatic islet. Data were analyzed descriptively and the microscopic findings showed that there were hydropic and lipid degeneration in all treatment and control groups as well as mild inflammation in one of the animals and no evidence of amyloid accumulation. As the conclution that nicotine oral administration on monkeys which fed high energy diets gave no difference in pancreatic microscopic finding amongs the groups
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Judul: Profil Bobot Badan, Indeks Massa Tubuh dan Glukosa Darah Monyet Ekor Panjang (Macaca fascicularis) yang Diberi Pakan Tinggi Energi dan Nikotin Cair
Abstrak: Nicotine with specific dose has been reported to have an affect to decreased appetite on rodents. Therefore, the objective of this study was to determine the effect of nicotine on body weight, body mass index and blood glucose levels of cynomolgus monkey (Macaca fascicularis) fed high energy diet given for three months. Ten adult males cynomolgus monkeys were randomly divided into two groups. The first group fed with main ingredient from beef tallow and the second group with commercial monkey chow. In both diets, nicotine liquid were added with final dosage consumed by monkeys of at least 0,75 mg/kg body weight. The design used in this study was complete randomized design in time. Data collected was analyzed to find correlation between time and treatment. Measurement was performed monthly on body weight, body mass index and blood glucose levels. Results showed that weight loss was not significant (P>0,05), however BMI and blood glucose level was decreased significantly in the first group (P<0,05). The conclusion of this study, nicotine intervention given for three months in adult male cynomolgus monkeys with high energy diet from beef tallow reduced blood glucose level and body mass index but not its body weigh
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Judul: Formulasi TSP (Traveling Salesman Problem) menggunakan ILP (Integer Linear Programming)
Abstrak: TSP is a journey of salesman f?om his origin town (place) to visit n-cities (places) only at once, then return to his origin town (place) with a minimum total distance. Its purpose is to minimize the operating expense that is released by the company. Vehicle route at TSP in the form of a Hamiltonian cycle, that is closed path containing all nodes at the graph which representing a network walk. Its problem is to determine a journey route which is feasible (possibly can be passed by) in such a way the vehicle travelled distance passed the route is minimum.
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