Judul: Protein Bioaktif Asal Kultur Akar Transgenik Blustru (Luffa cylindrica (L.) Roem) dan Aktivitasnya dalam Menghambat Proliferasi Sel Tumor secara IN VITRO
Abstrak: Penelitian ini bertujuan menentukan fenotip, pertumbuhan dan biomassa agar transgenik Luffa cylindrrea (L.) Roem, menentukan konsentrasi protein bioaktif akar transgenik dan biji hasil ektraksi dan pufikasi, serta membandingkan aktivitas protein bioaktif akar transgenikdan biji terhadap tiga macam sel lestari tumor.
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Judul: Efektifitas ekstrak kloroform biji blustru(Luffa cylindrica) terhadap aktivitas penghambatan sel lestari tumor MCM-B2 dan HeLa secara in vitro
Abstrak: Kanker adalah salah satu ancaman kematian terbesar di dunia, sebanding dengan bertambahnya usia lanjut. Setiap kali jumlah usia lanjut bertambah, semakin banyak kasus kanker ditemukan dan sulit dideteksi secara dini. Menangani kanker memang tidak selalu dengan operasi tetapi dapat dilakukan dengan pemberian terapi maupun obat antitumor/antikanker. Salah satu alternatif pengobatan kanker yang sedang banyak dikembangkan saat ini adalah antikanker yang berasal dari produk tanaman. Penelitian ini bertujuan untuk mengetahui aktivitas antiproliferasi dari ekstrak kloroform biji Blustru (Luffa cylindrica) terhadap sel lestari tumor MCM-B2 dan HeLa secara in vitro. Nilai LC50 dari ekstrak kloroform biji Blustru diperoleh dari metode Brine Shrimp Lethality Test yang dihitung dengan analisis probit yaitu 65 ppm, sehingga dapat diperkirakan dosis (konsentrasi ekstrak kloroform biji Blustru) yang akan diuji aktivitas antiproliferasinya terhadap sel lestari tumor MCM-B2 dan Hela. Kedua jenis sel tumor ditanam masing-masing pada Tissue Culture Plate 24 Well dengan konsentrasi berdasarkan L.C50 yaitu 25 ppm (P1), 50 ppm (P2), 75 ppm (P3), 100 ppm (P4), dan kontrol negatif (K-) dengan tiga kali pengulangan. Pemanenan dan penghitungan dilakukan setelah diinkubasikan pada suhu 37°C dan CO₂ 5% selama 3 hari. Hasil uji aktivitas antiproliferasi ekstrak kloroform biji Blustru terhadap sel lestari tumor MCM-B2 mencapai aktivitas antiproliferasi tertinggi pada dosis 75 dan 100 ppm yaitu 27,27%. Sedangkan hasil uji ekstrak kloroform Biji Blustru terhadap aktivitas antiproliferasi sel lestari tumor HeLa mencapai aktivitas antiproliferasi tertinggi pada dosis 50 ppm yaitu 42,29%.
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Judul: Variabilitas Suhu Permukaan Laut dan Interelasinya dengan Muson, Dipole Mode (DM) dan El Nino Southern Oscillation (ENSO) di Perairan Asia Tenggara dan Sekitarnya.
Abstrak: Variability of air-sea interaction in the Southeast Asia and its surrounding waters has an important role for regulating the Asian and Australian climate dynamics and the dynamics of ocean-atmosphere in the Indian and Pacific Oceans. The results of the first five largest variance of Empirical Orthogonal Function (EOF) analysis of monthly mean sea surface temperature between 1979- 2007 from data assimilation of Geophysical Fluid Dynamics Laboratory (GFDL) in the Southeast Asia waters are able to identify occurrence of the Monsoon activity, the period of Dipole Mode (DM) in Indian Ocean and types of El Nino Southern Oscillation (ENSO) in the Pacific Ocean. The heat dynamics of the sea and atmosphere in the Indonesia waters are probably the triggers of DM and ENSO after performing spectral density function of EOF expansion coefficients, wavelet transform and composite analysis based on one times of standard deviation above positive and below negative of expansion coefficient using Earth System Research Laboratory-National Oceanic Atmospheric Administration (ESRL-NOAA) dataset, including wind data, air temperature, air pressure, outgoing long wave radiation (OLR), rainfall, precipitation, evaporation, sensible heat, latent heat and humidity. Schematics of the dynamical processes of oceanatmosphere interaction were constructed based on composite analysis results by discovering unique pattern which are called as phase of Asymmetric Monsoon of Southeast Asia waters (AMSA), Heat Storing/releasing of Southeast Asia waters (SRSA), Dipole Mode of Southeast Asia waters (DMSA), Tripole Mode of Southeast Asia waters (TMSA) and the Mixed Mode of Southeast Asia waters (MMSA) to examine more insightful of the relationships between heat dynamics in the Southeast Asia and the origin processes of Monsoon, DM and ENSO. The rest difference of heat accumulation of AMSA phase in the Southeast Asia are therefore led to a shift of Monsoon and triggering a biennial cycle of the Tropical Biennial Oscillation (TBO) associated with decadal cycle in the SRSA phase is the beginning of DM and ENSO activity. After couple times of biennial cycle, the remaining difference of heat accumulation in the Southeast Asia is getting bigger and needed a new heat balance that generates a trigger of DM period and some types of ENSO. At the DMSA phase was formed DM transition period and conventional ENSO pattern, the TMSA phase as DM transition period and Central Pacific ENSO spread type (CP El Nino/La Nina spread type) and the MMSA phase which coincided peak of DM and Central Pacific ENSO centralized type (CP El Nino/La Nina centralized type).
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