Judul: Histopatologi Organ Limpa Tikus Diabetes yang Diinduksi Streptozotocin dan Diobati dengan Bubuk Kelapa Muda Kering Beku
Abstrak: Diabetes mellitus (DM) is widely recognized as one of the leading causes of death and disability worldwide. This study aims to study the histopathological features of the spleen of diabetic rats treated with freeze-dried young coconut compared with glibenclamide as a positive standard for DM treatment. Nine male Sprague-Dawley rats were divided into five treatment groups which were all induced diabetes using streptozotocin at a dose of 55 mg/kg, except for the normal group (KN) which was only given 1 mL of distilled water. The diabetes group (KD) was given 1 mL of distilled water, the positive control (DG) was given glibenclamide 0.6 mg/kg BW, DSK3.5 was given 3,5 g/kg BW freeze-dried young coconut, and the DSK7 group was given 7 g/kg BW freeze-dried young coconut orally as a feed supplement. All rats were euthanized, and spleens were sampled to make histopathological preparations using hematoxylin-eosin staining. DSK3.5 showed improvement, namely a decrease in total lymphoid follicles and an increase in size and density. Although not significantly different, these findings indicate that freeze-dried young coconut has an effect similar to glibenclamide, allowing it to be considered as an option for DM therapy., Diabetes mellitus (DM) diakui secara luas sebagai salah satu penyebab utama kematian dan kecacatan di seluruh dunia. Penelitian ini bertujuan untuk mempelajari gambaran histopatologi limpa tikus diabetes yang diberi perlakuan kelapa muda kering-beku dengan konsentrasi berbeda, dan dibandingkan dengan glibenklamid sebagai standar positif pengobatan DM. Sembilan ekor tikus jantan Sprague-Dawley dibagi menjadi lima kelompok perlakuan yang seluruhnya diinduksi diabetes menggunakan streptozotocin (STZ) dosis 55 mg/kg, kecuali kelompok normal (KN) yang hanya diberi akuades 1 mL. Keempat kelompok lainnya yaitu kelompok diabetes (KD) yang diberi akuades 1 mL, kontrol positif (DG) diberi glibenclamide 0,6 mg/kg BB, DSK3.5 diberi air kelapa kering-beku 3,5 g/kg BB, dan kelompok DSK7 diberi air kelapa kering-beku 7 g/kg BB per oral sebagai supplemen. Seluruh perlakuan dilaksanakan sehari sekali selama 45 hari. Selanjutnya seluruh tikus dieutanasi, limpa disampling untuk dibuat sediaan histopatologi dan diwarnai dengan hematoxilin-eosin. Tikus DM yang diberi air kelapa muda kering-beku 3,5 g/kg BB (DSK3.5) menunjukkan limpa yang membaik yaitu folikel limfoid total berkurang namun ukuran dan kepadatan folikel limfoid meningkat. Meskipun tidak berbeda signifikan, temuan ini menunjukkan bahwa air kelapa muda kering-beku memiliki pengaruh yang mirip dengan glibenklamid sehingga dapat dipertimbangkan sebagai pilihan untuk terapi DM.
Keyword: Cocos nucifera, diabetes, freeze-dried, histopathology, spleen

Judul: Gambaran Histomorfologi Hati, Usus Halus, dan Limpa pada Tikus Hiperglikemia yang Diberi Ekstrak Sambiloto
Abstrak: REZI ZAHRA AZIZA. B04051740. Histomorphological Aspect of Liver, Small Intestine, and Spleen of Diabetic Model Rat that was Treated with Sambiloto Extract. Under direction of ADI WINARTO and EKOWATI HANDHARYANI The purpose of this study is to evaluate the histomorphological aspect of liver, small intestine, and spleen of diabetic model rats that were treated with sambiloto extract. Twenty-four male Spraque-Dawley rats were divided into 2 groups of models. Diabetic model group was induced by Streptozotocin (40 mg/kg BW) intra-peritonially, and a healthy group which recieved Phosphat Buffer Saline (PBS) pH 7.4 intra-peritonially. The both of groups were treated with sambioto daily within 4 weeks. Rat model of diabetes with low sugar levels and high at the time of sacrifice was observed as a distinct group. Observations on the liver, small intestine, and spleen of non-diabetic group showed that the provision does not affect the morphological sambiloto liver, small intestine, and spleen. Observations on liver of rat diabetic model with blood sugar levels are still high indicates a change in the form of congestion and degeneration, in the small intestine seen an increase in the number of Goblet cells and mitotic cells but did not find any picture of damage to the mucosal epithelium. Changes are seen in the spleen leads to degeneration until necrosa, and spleen increased with the emergence of readiness germinal centers. Evaluation of the liver, small intestine, and spleen model of diabetes with a decrease in blood sugar showed an improvement histomorfologis picture to approach the image on the non-diabetic group. Keyword :Diabetic, Sambiloto, Liver, Small Intestine, Spleen
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Judul: Solusi Problem Gaussian Pairing Dalam Basis Osilator Harmonik Menggunakan Teori Perturbasi Dan Metode Numerik
Abstrak: This study aims to determine the profile of the energy and the wave function of a harmonic oscillator system under the effect of a Gaussian potential. This function can be used to model such fermions. The solution of this problem can be described by more efficiently using a perturbation theory based on the harmonic oscillator. The first four levels of energy and the wave function has been described using the analytical method and Numerical Methods . These results are displayed in graphical form . Wave function is shown in graphic form relation between the wave function and atomic distance, whereas energy shown in the form of relation between energy and the pairing constant g. From the graph shows that the ground state and the first excitation energy of the system will decrease with increasing pairing constant g, whereas for the higher excitation energy of the system increases with increasing pairing constant g. This is because when the system is in the ground state and the first excitation, the system tends to be localized in one place, whereas at higher excitation , the system will often be not only in one place, but some places are indicated by the peaks of density of system . Energy system obtained from the analytical and numerical methods haven’t significant. This is mean that to analize a higher excitation state can use numerical methods such as Numerov Method and Shooting Method to be more efficient
Keyword: Shooting Method, Harmonic Oscillator, Numerov Method, Gaussian Pairing