Judul: Potensi Antikanker Royal Jelly Apis mellifera terhadap Sel WiDr ATCC®-CCL™ 218 dan Sel HeLa ATCC®-CCL-2™
Abstrak: Kanker serviks merupakan kanker penyebab kematian wanita kedua terbesar setelah kanker payudara di Indonesia, sedangkan kanker kolon merupakan kanker penyebab kematian pertama di dunia setelah penyakit jantung koroner. Salah satu upaya pengobatan kanker yang dapat dilakukan adalah mengkonsumsi bahan yang berpotensi sebagai antikanker, salah satunya adalah royal jelly Apis mellifera. Berdasarkan penelitian sebelumnya, royal jelly mampu menginhibisi sel kanker payudara MCF-7 1 mg/mL dan sel kanker kolon CaCo-2 0.5 mg/mL. Tujuan dari penelitian ini adalah menguji aktivitas sitotoksik royal jelly Apis mellifera terhadap sel kanker serviks (HeLa) dan sel kanker kolon (WiDr) dan sel hati (Chang) secara in vitro. Hasil uji antikanker menunjukkan potensi antikanker royal jelly lebih baik terhadap sel HeLa dibandingkan sel WiDr. Aktivitas royal jelly terhadap sel normal Chang mampu meningkatkan pertumbuhan sel sebesar 42.30% ± 13.01. Royal jelly mampu menghambat 36.42% ± 7.90 pertumbuhan sel HeLa, sedangkan terhadap sel WiDr hanya menghambat 16.65% ± 4.80 pada konsentrasi 125 g/mL.
Keyword: kanker kolon, kanker serviks, MTT, royal jelly

Judul: Cytotoxicity Test and Colon Anticancer Activity of the Monoflora Honey of Bees (Apis Mellifera) with Variations of Nectar Sources
Abstrak: Kanker kolon merupakan kanker dengan jumlah kasus dan jumlah kematian terbanyak di dunia. Madu monoflora dari Apis mellifera merupakan salah satu bahan alam yang berpotensi sebagai antikanker kolon dan memerlukan kajian lebih lanjut karena efektivitasnya dipengaruhi oleh perbedaan jenis sumber nektar. Penelitian ini bertujuan menentukan jenis madu monoflora Apis mellifera yang sumber nektarnya berasal dari tanaman-tanaman di Indonesia sebagai antikanker kolon terbaik berdasarkan nilai LC50 dan persentase inhibisi terhadap sel WiDr. Madu diuji dengan metode BSLT dan MTT assay kemudian data dianalisis secara statistik serta dilakukan PCA dan klasterisasi K-means. Hasil penelitian menunjukkan seluruh madu berpotensi sebagai antikanker kolon. Analisis biplot pada PCA dan klasterisasi K-means menunjukkan madu dengan potensi antikanker kolon terbaik adalah madu akasia, madu mangga, dan madu kapuk randu. Ketiga madu tersebut memiliki nilai LC50 rendah dengan metode BSLT, yaitu masing-masing sebesar 153,816 ppm, 164,207 ppm, dan 170,053 ppm. Ketiga madu tersebut memiliki persentase penghambatan yang besar terhadap sel kanker WiDR, yaitu masing-masing sebesar 72,42%, 74,31%, dan 63,96%., Colon cancer is a cancer with the highest number of cases and deaths in the world. Monoflora honey from Apis mellifera is one of the natural ingredients that has the potential as an anticancer colon and requires further study because its effectiveness is influenced by different types of nectar sources. This study aims to determine the type of Apis mellifera monoflora honey which sources its nectar from plants in Indonesia as the best colon anticancer based on the LC50 value and the percentage of inhibition against WiDr cells. Honey was tested using the BSLT and MTT assay methods, then the data was analyzed statistically and PCA and K-means clustering were carried out. The results showed that all honey has the potential as an anticancer colon. Biplot analysis on PCA and K-means clustering showed that the honey with the best colon anticancer potential was acacia honey, mango honey, and kapok honey. The three honeys had low LC50 values using the BSLT method, namely 153,816 ppm, 164,207 ppm and 170,053 ppm respectively. The three honeys had a large percentage of inhibition against WiDR cancer cells, namely 72,42%, 74,31% and 63,96%, respectively.
Keyword: cytotoxicity, antiproliferation, honey, nectar, clustering

Judul: Variabilitas Suhu Permukaan Laut dan Interelasinya dengan Muson, Dipole Mode (DM) dan El Nino Southern Oscillation (ENSO) di Perairan Asia Tenggara dan Sekitarnya.
Abstrak: Variability of air-sea interaction in the Southeast Asia and its surrounding waters has an important role for regulating the Asian and Australian climate dynamics and the dynamics of ocean-atmosphere in the Indian and Pacific Oceans. The results of the first five largest variance of Empirical Orthogonal Function (EOF) analysis of monthly mean sea surface temperature between 1979- 2007 from data assimilation of Geophysical Fluid Dynamics Laboratory (GFDL) in the Southeast Asia waters are able to identify occurrence of the Monsoon activity, the period of Dipole Mode (DM) in Indian Ocean and types of El Nino Southern Oscillation (ENSO) in the Pacific Ocean. The heat dynamics of the sea and atmosphere in the Indonesia waters are probably the triggers of DM and ENSO after performing spectral density function of EOF expansion coefficients, wavelet transform and composite analysis based on one times of standard deviation above positive and below negative of expansion coefficient using Earth System Research Laboratory-National Oceanic Atmospheric Administration (ESRL-NOAA) dataset, including wind data, air temperature, air pressure, outgoing long wave radiation (OLR), rainfall, precipitation, evaporation, sensible heat, latent heat and humidity. Schematics of the dynamical processes of oceanatmosphere interaction were constructed based on composite analysis results by discovering unique pattern which are called as phase of Asymmetric Monsoon of Southeast Asia waters (AMSA), Heat Storing/releasing of Southeast Asia waters (SRSA), Dipole Mode of Southeast Asia waters (DMSA), Tripole Mode of Southeast Asia waters (TMSA) and the Mixed Mode of Southeast Asia waters (MMSA) to examine more insightful of the relationships between heat dynamics in the Southeast Asia and the origin processes of Monsoon, DM and ENSO. The rest difference of heat accumulation of AMSA phase in the Southeast Asia are therefore led to a shift of Monsoon and triggering a biennial cycle of the Tropical Biennial Oscillation (TBO) associated with decadal cycle in the SRSA phase is the beginning of DM and ENSO activity. After couple times of biennial cycle, the remaining difference of heat accumulation in the Southeast Asia is getting bigger and needed a new heat balance that generates a trigger of DM period and some types of ENSO. At the DMSA phase was formed DM transition period and conventional ENSO pattern, the TMSA phase as DM transition period and Central Pacific ENSO spread type (CP El Nino/La Nina spread type) and the MMSA phase which coincided peak of DM and Central Pacific ENSO centralized type (CP El Nino/La Nina centralized type).
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