Judul: Perbandingan metode pemulusan brown dan holt pada peramalan gempa bumi se-Jawa Barat-Banten
Abstrak: Metode pemulusan eksponensial merupakan salah satu, metode peramalan yang menggunakan pembobotan data masa lalu secara eksponensial. Metode pemulusan eksponensial ganda satu parameter dari brown dan metode pemulusan ganda dua parameter dari holt digunakan untuk mengprediksi banyaknya gempa bumi se-Jawa Barat-Banten di masa yang akan datang.
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Judul: Pendugaan Hazard Rate Gempa di Provinsi Aceh dengan Metode Single Decrement
Abstrak: Hazard rate has a significant effect on the earthquake forecasting. If the hazard rate is given then the joint density distribution of earthquake occurrences can be identified. Therefore we need a parametric model that accurately estimates the hazard rate. In this paper a method to estimate the hazard rate at a point 􀝐������􀬴������ is discussed. The method used is single decrement method. There are two approaches that can be used to estimate the hazard rate using the method of single decrement, those are likelihood approach and the moment approach. The likelihood approach requires an assumption on the distribution of the waiting time of earthquake occurrences. In this paper the distribution of waiting time of earthquake occurrences is assumed to be linear, exponential, and hyperbolic. Estimation of the hazard rate uses earthquake data in Aceh with power greater than or equal to 5 SR. The approach used is likelihood approach. Parametric model obtained from this method is expected to estimate the hazard rate accurately.
Keyword: waiting time., joint density distribution, hazard rate, earthquake

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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