Judul: Perubahan Penggunaan Lahan dan Pengaruhnya terhadap Perkembangan Wilayah di Wilayah Pengembangan Bogor Barat Kabupaten Bogor
Abstrak: Kabupaten Bogor merupakan salah satu kawasan pendukung ibukota DKI Jakarta selain Kota Bogor, Bekasi, Depok dan Tangerang, sekaligus hinterland bagi Kota Bogor sendiri yang telah banyak mengalami perubahan penggunaan lahan akibat perkembangan wilayah yang pesat yang dipicu oleh pertambahan penduduk. Pertambahan penduduk ini mempengaruhi penggunaan lahan akibat meningkatnya kebutuhan manusia. Penelitian ini bertujuan untuk mengetahui perubahan dan pola perubahan penggunaan lahan, mengetahui tingkat perkembangan wilayah dan pengaruh keterkaitan perubahan penggunaan lahan terhadap indeks perkembangan wilayah dengan mengambil studi kasus di Wilayah Pengembangan Bogor Barat Kabupaten Bogor. Wilayah Pengembangan Bogor Barat merupakan salah satu wilayah pengembangan di Kabupaten Bogor yang direncanakan menjadi kabupaten baru. Pesatnya tingkat perkembangan wilayah dan laju urbanisasi di ibukota Jakarta dan sekitarnya menyebabkan dinamika perubahan penggunaan lahan juga terjadi di Wilayah Pengembangan Bogor Barat. Oleh karena itu, perencanaan dan pengendalian akan penggunaan lahan harus diperhatikan agar tidak menjadi rintangan ketika wilayah tersebut menjadi suatu wilayah administrasi baru. Wilayah Pengembangan Bogor Barat memiliki luas ± 132,793.70 ha, dengan penggunaan lahan yang beragam. Dari hasil penelitian yang dilaksanakan dengan mengambil data di tahun 2000, 2006, 2011, 2015 dan 2018, dapat diketahui bahwa dari tahun ke tahun, Wilayah Pengembangan Bogor Barat mengalami perubahan penggunaan lahan. Penelitian ini dilakukan pada bulan Oktober 2017 sampai Juni 2018. Penggunaan lahan di Wilayah Pengembangan Bogor Barat didominasi oleh ladang / tegalan, kemudian sawah, hutan, tanaman tahunan, lahan tidur, lahan terbangun, badan air dan pertambangan, dengan 11 pola perubahan yang dominan dengan luas lebih dari 1,000 ha. Hasil analisis korelasi menunjukkan bahwa secara umum penggunaan lahan di Wilayah Pengembangan Bogor Barat memiliki keterkaitan dalam mempengaruhi tingkat perkembangan wilayah, walaupun keterkaitannya tidak terlalu kuat. Satu-satunya jenis perubahan penggunaan lahan yang memiliki korelasi positif yang kuat terhadap tingkat perkembangan wilayah adalah perubahan dari sawah menjadi lahan terbangun, dengan nilai korelasi sebesar 0.76.
Keyword: land use pattern, population growth, regional development index

Judul: Analisis Perubahan Penggunaan Lahan, Pola Ruang dan Tingkat Perkembangan Wilayah di Kota Bogor
Abstrak: Bogor City is located 60 kms from the Indonesian Capital Jakarta and 120 kms from Bandung the capital of West Java Province. Strategic agricultural land and inexpensive land price have encouraged stakeholders to invest in agricultural sector and also non agricultural sector. Land use conversion is inevitable, although the goverment has set up the regulation to control land usage (Act No 26 year 2007). This research are conducted: (1) To analyze existing land use of Bogor City (land use in 2014). (2) To analyze the land use change in period of 2005-2012. (3) To analyze the consistency of existing land use compare to land allocation in the RTRW of Bogor City. (4) To identify regional development hierarchy level in Bogor City. (5) To determine factors that influencing land use change. This research was started with land usage map designing which retrieved from digitized result on administrative map 1: 5000 scales to ikonos image of Bogor City in years of 2005 and 2012. Consistency and inconsistency is obtained by overlaying land use map in 2012 and land allocation map of Bogor City years 2011-2031 (RTRW map). PODES is used to determine the regional hierarchy level by multiple regression method. Existing land use classified into 9 land use, in sequence from the largest one are: mixed garden, non-wellarrang ed settlement, paddy field, well arranged settlement, trade area, water body, dryland farm, open field and goverment office area. Dryland farm land use changes into 2 land use, open field land use change into 6 land use and paddy field land use change into 6 land use. The consistent existing land use compare to RTRW is 40.95% while inconsistence existing land use is 59.05%. During period of 2006 to 2012, most of regional development hierarchy in Bogor City are the relative constant hierarchy (42 villages/61.8%). 12 villages (17.6%) are increase in the hierarchy whilst 14 villages (20.6%) are decrease in the hierarchy. Factors that influencing land use change of Bogor City in period of 2005-2012 are: area of agricultural land in the years of 2005, social facilities growth, and economy facilities growth
Keyword: Spatial Plan., Regional Hierarchy, Land Use Inconsistency, Land Use Conversion

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
Keyword: