Judul: Formulasi Strategi Pengembangan Usaha pada PT Sepatu Bata tbk
Abstrak: Liberalisasi perdagangan melalui AFTA dan APEC akan membawa dampak yang besar bagi Indonesia. Para pelaku bisnis di dunia akan menghadapi tantangan era perdagangan bebas dimana persaingan akan menjadi semakin ketat. PI Sepatu Bata Ibk merupakan salah satu perusahaan multidomestik yang memenu hi kebutuhan konsumsi sepatu dan alas kaki di Indonesia. Disaat semakin meningkatnya persaingan sepertinya sinar Bata sebagai salah satu merk yang dulu sangat disegani reputasi Bata kini kian melemah. Meskipun outlet PI Sepatu Bata Tbk masih yang terbanyak tetapi nama Bata mulai tenggelam diantara persaingan dengan banyak merk lokal maupun internasional yang selalu gencar melakukan periklanan untuk promosl.
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Judul: Formulasi Strategi Unit Bisnis Pensil Tulis Dan Pensil Warna PT.A.W.Faber-Castell Indonesia
Abstrak: Adanya perubahan lingkungan terutama perekonomian telah membawa dampak terhadap perkembangan industri di dalam negeri. Menjelang era perdagangan bebas sebagaimana yang telah disepakati dalam kerangka AFTA, APEC dan WTO, setiap perusahaan harus menghadapi persaingan ketat dengan perusahaan-perusahaan di seluruh dunia, namun dengan adanya perubahan lingkungan yaitu situasi krisis moneler yang berkepanjangan dalam negeri telah mempersulit suatu perusahaan untuk bertahan dan beradaptasi terhadap perubahan yang terjadi. Liberalisasi perdagangan pada tahun 2003 dapat menjadi suatu peluang sekaligus ancaman yang besar bagi industri dalam negeri.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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