Judul: Hepatoprotector  Potential  of  Rosella  Extract  (Hibiscus  sabdariffa  L)  on  The  Liver  of  Paracetamol-induced  rats.
Abstrak: Paracetamol is one of the most common analgesic and antipyretic for relieving headache and fever. Prolonged use of paracetamol in high dose can produce liver necrosis and damage the kidney. Rosella (Hibiscus sabdariffa L) has the ability to prevent liver necrosis. Therefore, the aim of this research was to determine the hepatoprotector effects of water extract of Rosella in lowering the transaminase acitivity and to examine its ability in regenerating the necrosis of hepatocyte on rats induced by high dose of paracetamol. The change in liver function was determined by microsopical observation with AST (aspartat transaminase) and ALT (alanin transaminase) level. AST and ALT Enzyme analysis was performed using IFCC method. Preparates for histopathology assay were made using modified Andrew Kent method. The induction of rosella water extract with dosage of 1,1 g/mL extract/kg BW, 3,3 g/mL extract/kg BW, and 5,5 g/mL extract/kg BW can lower the ALT activity on 35th day for 61,90%, 62,52%, and 63,27% and AST activity on 35th day for 61,90%, 62,52%, and 63,27% respectively. Observation on histopatology showed that treatment with 1,1 g/mL extract/kg BW had better ability to regenerate hepatocyte compared with both 3,3 g/mL extract/kg BW and 5,5 g/mL extract/kg BW.
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Judul: Uji aktivitas hepatoprotektor ekstrak air pegagan (Centella asiatica) terhadap tikus putih jantan yang diinduksi parasetamol
Abstrak: This study was undertaken to investigate activity of Centella asiatica extract against paracetamol induced liver damage in male Wistar albino rats. Rats were divided into five groups namely control (aquadest), herb extract with four formulations which were F 6, F 10, F 12, and F 16. Rats were administered paracetamol at dose 1000 mg/kg bw (p.o) as toxic dose for inducing hepatotoxicity. Herb extract in each formula was given at dose 1500 mg/kg bw (p.o) one hour after paracetamol administration. The treatment was given for eight days and blood was collected three times (before treatment, after paracetamol treatment, and last treatment) from tail artery and analysed for serum glutamate pyruvate transminase (SGPT). The hepatoxicity produced by acute paracetamol administration was found to be inhibited by Centella asiatica at group F 16 with evidence of decreased level of serum glutamate pyruvate transminase (SGPT) consentration. The hepatoprotective activity Centella asiatica was also supported by histopathological studies of hepatocytes
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Judul: Construction of Strongly Optimal Binary Linear Code with Minimum Distance 9 and 11
Abstrak: A binary linear code of length n over q F is a subspace of n q F . A code has three parameters that attached to it, namely length, dimension, and minimum distance. A code with length n, dimension k and minimum distance d is often called [n, k, d ]-code. Usually, when two parameters are given, then we want to find a code that has the best value for the last parameter. Based on Gilbert- Varshamov bound, if a [n, k, d ]-code exists and can not be expanded, we call it a strongly optimal code. In this paper, we construct strongly optimal code with minimum distance 9 and 11. In constructing the code, we created a theorem and algorithm based on Gilbert-Varshamov bound before we implement the algorithm to MAPLE programming language. Because of computational limitations, the program can only construct up to k = 10 for d = 9 and k = 12 for d = 11.
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