Judul: Extraction of Active Compound of Ulva lactuca Based on Natural Deep Eutectic Solvents (NaDES) and of Anticancer Activity on MCF-7
Abstrak: Ulva lactuca memiliki berbagai komponen senyawa fenol dan berpotensi dikembangkan dalam bidang industri farmasi. Pemilihan pelarut ekstraksi yang baik dan tepat dapat memengaruhi bioaktivitas suatu ekstrak, seperti aktivitas antioksidan dan antikanker. Penggunaan pelarut berbasis Natural Deep Eutectic Solvent (NaDES) untuk proses ekstraksi meningkat karena memiliki sifat tidak toksik dan ramah lingkungan. Komponen aktif dari U. lactuca diekstraksi menggunakan berbagai jenis NaDES, kemudian diuji total kandungan fenol dan uji antioksidan dengan DPPH dan ABTS. Ekstrak U. lactuca berbasis NaDES yang berpotensi kemudian difraksinasi lalu aktivitas sitotoksik dari ekstrak tersebut dievaluasi dengan metode Brine Shrimp Lethality Test dan sebagai penghambat pertumbuhan sel kanker dengan uji MTT menggunakan kultur sel kanker payudara MCF-7. Perlakuan proses pengeringan metode oven terhadap U. lactuca menjadi perlakuan yang terbaik dalam menghasilkan bioaktivitas. Komponen senyawa aktif dari U. lactuca yang diekstraksi berbasis NaDES menghasilkan total kandungan fenol dan aktivitas antioksidan yang tidak berbeda nyata. Nilai toksisitas dari fraksi H2O 100% ekstrak NaDES 2 U. lactuca perlakuan pengeringan angin-angin tergolong toksik dengan nilai LC50 sebesar 56,9
Keyword: pengeringan, senyawa aktif, Ekstraksi, NaDES, Ulva lactuca

Judul: Green Extraction Hydrophobic Pigment from Ulva lactuca as Natural Antioxidant
Abstrak: Ulva lactuca has chlorophyll and carotenoid pigments that are important in biomedical application, particularly for cancer chemoprotection, heart and blood vessel disease prevention, cataract prevention, alzheimer's disease prevention, and other chronic diseases. U. lactuca as a promising biomaterial has strong antioxidant characteristics. Acceleration of the ultrasonic method in extraction produces higher yields with shorter extraction time. In this research, the promising solvent Natural Deep Eutectic Solvent (NADES) opens up new possibilities. In a 30 minutes ultrasonication, pigments with chloroform (K), NADES (N), and theirs combinations at different ratios (K100, K75N25, K50N50, K25N75, and N100) produced the best chlorophyll a, chlorophyll b, and carotenoid pigment characteristics, respectively, at the highest concentrations at treatment K75N25 (13,38±0,94 mg/L), K100 (10,21±1,10 mg/L), and N100 (17,59±0,54 mg/L). The compounds identified from the functional groups in hydrophobic U. lactuca pigments were alkanes, amides, aromatic and aromatic amines. The antioxidant activity of U. lactuca pigments were very strong; N100 (IC50 = 5,02 ppm), K100 (IC50 = 9,02 ppm), and N50K50 (IC50 = 17,22 ppm).
Keyword: antioxidant, hydrophobic pigment, Natural Deep Eutectic Solvent, Ulva lactuca

Judul: Asymptotic Distribution of Estimator for the Intensity Function of a Doubly Periodic Poisson Process
Abstrak: In this manuscript, estimation of the intensity function of a doubly periodic Poisson process is discussed. It is assumed that only a single realization of the Poisson process is observed in a bounded window [0,n]. It is also assumed that the period of the intensity function is known. The rate of consistency and asymptotic normality of the estimator are formulated. Finally, a confidence interval for the local intensity function is also formulated.
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