Judul: Uji Simplisia Daun Srikaya (Annona squamosa L) terhadap Kompleksitas Dendrit pada Hipokampus dan Kinerja Memori Spasial
Abstrak: Srikaya mengandung senyawa anonaine yang berpotensi sebagai neuroprotektif serta diketahui dapat meningkatkan memori pada tikus epilepsi. Oleh karena itu penelitian ini bertujuan menguji pengaruh pemberian simplisia daun srikaya terhadap kompleksitas dendrit hipokampus dan kinerja memori spasial mencit dewasa. Penelitian ini dilakukan pada tiga kelompok hewan uji, yaitu kelompok uji satu sebagai kontrol, kelompok uji dua diberikan simplisia daun srikaya dengan dosis 0.3 g/kgBB dan kelompok uji tiga diberikan simplisia daun srikaya dengan dosis 0.5 g/kgBB. Kelompok uji dosis 0.3 g/kgBB memiliki memori spasial yang lebih tinggi dibandingkan dengan kelompok uji kontrol dan kelompok uji dosis 0.5 g/kgBB. Terjadi penurunan kompleksitas dendrit di wilayah girus dentatus pada hewan uji kelompok dosis 0.5 g/kgBB. Terjadi peningkatan kompleksitas dendrit di wilayah CA1 basal dan apikal pada hewan uji kelompok dosis 0.5 g/kgBB. Hasil analisis densitas sel memiliki jumlah yang berbeda-beda pada setiap hewan uji
Keyword: kompleksitas dendrit, memori spasial, densitas sel

Judul: Uji Simplisia Daun Sirsak (Annona muricata L.) terhadap Kompleksitas Dendrit Hipokampus dan Kinerja Memori Spasial Mencit (Mus musculus).
Abstrak: Daun sirsak (Annona muricata L.) dipercaya oleh masyarakat dapat meningkatkan fungsi kerja otak. Penelitian ini bertujuan mengetahui potensi daun sirsak (Annona muricata L.) terhadap kompleksitas dendrit hipokampus dan kinerja memori spasial. Hewan uji dibagi menjadi 3 perlakuan, yaitu kontrol, simplisia daun sirsak dosis 0.003 g, dan simplisia daun sirsak dosis 0.006 g. Kinerja memori spasial mencit diamati di dalam Y-maze selama 5 menit. Analisis neurogenesis hippocampus menggunakan metode pewarnaan Haematoksilin-eosin, sedangkan pengujian kompleksitas dendrit diamati menggunakan metode pewarnaan Golgi-Cox. Pemberian simplisia daun sirsak tidak berpengaruh signifikan dalam meningkatkan kemampuan memori spasial. Analisis densitas sel menunjukkan peningkatan rata-rata jumlah sel neural progenitor cell (NPC) dan sel granuler serta penurunan sel apoptotik pada dosis 0.003 g. Pemberian perlakuan tidak memengaruhi kompleksitas dendrit pada wilayah dentate gyrus. Pemberian perlakuan memengaruhi kompleksitas dendrit pada wilayah CA 1 bagian apikal dan basal hipokampus.
Keyword: densitas sel, kompleksitas, memori spasial

Judul: Thermal Characteristics and Dynamics of Tropical Cyclone over Western North Pacific Ocean: A Case Study of Typhoon Songda (Chedeng) 2011
Abstrak: The frequent occasion of Tropical Cyclone (TC) over Western North Pacific (WNP) Ocean lies from 10˚N to 26˚N and 121˚E to 170˚E. Sources of TC development come from warm ocean temperature where latent heat is released during condensation processes and subsequently concentrated in the boundary layer. Relative humidity at 850-700 hPa is responsible to produce the most intense storm. Meanwhile, weak vertical wind shear between 850-200 hPa is one of the dynamical factors that lead to the development of TC. Pressure level of 850-200 hPa is chosen to minimize the thermodynamic effect in the lower troposphere. Typhoon Songda (Chedeng in the Philippines) or TSC lasted from May 18th to 30th, 2011 and strengthened into powerful Super Typhoon stage between May 24th and 27th. Long curving track and the exhibition of all sequences of TC life cycle, TSC is then considered as an ideal case of TC. The objective of the study with case of TSC is to investigate the role of thermal characteristics and dynamics on TC intensity. The research is carried out by using Advanced Research of Weather Research and Forecasting model (WRF ARW model) version 3.3. Two domains are employed in the model. The first domain situate from 02˚N to 40˚N and 118˚E to 149˚E and cover spatial resolution () of 33.1 km. The second domain situate from 09˚N to 27˚N and 119˚E to 132˚E with of 11 km. Timestep of the model () is 120 seconds. The model is supported by the following physical parameterization, i.e., Yonsei University Scheme (YSU) in the boundary layer, Kain-Fritsch scheme (KF) in the cumulus, and WRF Single-Moment 3-class scheme in the microphysics. Initial meteorological condition prior to the formation of the cyclone is generated using WRF ARW standard-release model. Sensitivity of the model output is obtained from a selected single-parameter change scenarios, namely, 10 % to 20 % decrease and increase of wind shear initial data at 850-200 hPa, and by 10 % to 20 % decrease of relative humidity initial data at 850-700 hPa. The result showed that the negative correlations between wind shear and intensity are found in wind shear scenarios. Wind shears of 10 ms-1 which lead to strengthening of the wind intensity in the early period of Typhoon development are found in wind shear scenarios. The effect of wind shear changes on wind intensity is statistically significant in the 20 % wind shear scenarios. During mature stage, weak wind intensity occurred when wind shear increase as given in the WRF standard-release and the 20 % decreasing scenario. Different situation is found in the 20 % increasing scenario where wind shear tend to weak and lead to strong wind intensity at this stage. Meanwhile, the reduction of moisture supply at 850-700 hPa resulting from 20 % decreasing relative humidity play a major role in the weakening of wind intensity and reduces mechanical energy of the cycle process as much as 300 J kg-1.
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