Judul: Aktivitas Antioksidan Nanokurkuminoid Varietas Temulawak Asal Balitro Pada Hati Tikus Jantan Sprague Dawley
Abstrak: Curcuma xanthorhiza Roxb. yang dikenal dengan nama temulawak adalah tanaman yang mengandung kurkuminoid dan memiliki sifat antioksidan. Karena bioavailabilitas kurkuminoid sangat rendah dalam tubuh sehingga diperlukan suatu penghantaran yang efisien ke dalam tubuh, seperti nanopartikel tersalut lemak padat. Tujuan penelitian ini adalah untuk mengukur aktivitas antioksidan hati tikus Sprague Dawley jantan secara in vivo dari nanokurkuminoid tersalut lemak padat keadaan stress oksidatif diinduksi CCl4. Analisis aktivitas antioksidan dilakukan dengan mengukur kadar Malondialdehida (MDA) dan aktivitas enzim Superoksida Dismutase (SOD), Glutation Peroksidase (GPx) dan Peroksidase (POX). Nanokurkuminoid yang diperoleh berukuran (114.4 ± 33.8) nm, dengan nilai indeks polidispersitas sebesar (0.233 ± 0.060). Efisiensi penjerapan kurkuminoid di dalam nanokurkuminoid yang didapatkan sebesar 70.96 ± 7.60 %. Hasil analisis pengukuran kadar MDA dan aktivitas enzim SOD, GPx dan POX menunjukkan bahwa nanokurkuminoid varietas temulawak asal balitro memiliki aktivitas antioksidan meskipun berdasarkan uji statistik diperoleh hasil yang tidak berbeda nyata (P>0.05) dengan kelompok normal.
Keyword: aktivitas enzim, antioksidan, hati tikus, in vivo, nanokurkuminoid.

Judul: Aktivitas Antioksidan Nanokurkuminoid Temulawak Lokal Ciemas Pada Tikus Sprague-Dawley Betina
Abstrak: Java turmeric (Curcuma xanthorrhiza) is a typical Indonesian plants that have antioxidant activity. Clinical testing showed that curcumin safe at high doses (12 g/day) but has low bioavailability. Delivery systems by making of solid lipid nanoparticles made to improve bioavailability of curcuminoids. This study aims to measure antioxidant activity of nanocurcuminoid coated solid lipid in female rat induced by CCl4. Analysis of antioxidant activity by measuring Malondialdehyde (MDA) levels and activity of superoxide dismutase (SOD), gluthatione peroxidase (GPX) and peroxidase (POX). Nanocurcuminoids size that obtained was 114.4±33.8 nm with polydispersity index 0.218 and adsorption efficiency 79%. The results showed that administration of nanokurkuminoid dose of 1500 mg/kg in female rats induced by CCl4 were able to reduce levels of MDA (4.34 nmol/mL) and increasing the activity of SOD (64.70 %), GPx (3208.02 mU/mL) and POX (3.13 mU/mL). These results indicate nanokurkuminoid have antioxidant activity.
Keyword: SLN., nanocurcuminoid, female sprague-dawley, CCl4, antioxidant

Judul: Hamiltonian formulation for linear waves motion in two layers fluid
Abstrak: The surface wave could be considered as a wave that separates two fluids, namely water and air. Based on this assumption, it is introduced the interfacial wave, a wave between two layers of fluid with different density. The formulation of interfacial waves motion begins with deriving the base equation of irrotational ideal fluid. Furthermore, according to irrotational fluid assumption, the base equation can be stated in velocity potential. In this derivation, the fluids domain is assumed to be restricted by rigid lid boundary conditions, both at the upper and lower limit. Therefore, the interfacial waves motion can be explained in a hamiltonian formulation. In the hamiltonian formulation, total energy is defined as the sum of kinetic and potential energy. The hamiltonian system is obtained from reduction of kinetic energy by using the Dirichlet Neumann Operator. The resulted kinetic energy equation is nonlinear. Therefore, this form is linearized by first part of the Taylor expansion. This linearization gives a dispersion relation of linear wave. Based on this dispersion relation, the phase speed of the linear wave depends on the density ratio of the two layers fluid.
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