Judul: Interaksi komunitas lokal di taman nasional gunung leuser: studi kasus kawasan ekowisata Tangkahan, Sumatera Utara
Abstrak: Penelitian ini dilatarbelakangi oleh keberadaan taman nasional telah menyebabkan terbatasnya akses komunitas lokal di dalam pemanfaatan sumber daya alam dalam rangka memenuhi kebutuhan hidupnya. Hal inilah yang menjadi titik terjadinya konflik kepentingan antara kepentingan konservasi dan kepentingan rakyat. Untuk mengatasi ini maka banyak taman nasional yang mengembangkan ekowisata di kawasannya karena bentuk pemanfaatannya dianggap dapat memberikan manfaat secara berkelanjutan dalam meningkatkan pendapatan komunitas lokal dan kelestarian kawasan tetap terjaga.
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Judul: Interaksi Masyarai{at dengan Taman Nasional Alas Purwo (Studi Kasus di Desa Kendalrejo Kecamatan Tegaldlimo Kabupaten Banyuwangi Propinsi Jawa Timur)
Abstrak: 8erubahnya status suatu kawasan menjadi taman nasional tclah mengakibatkan masyarakat sekitar yang sudah sejak dulu berinteraksi dengall kawasan taman nasional secara de jure kehilangan akses terhadap sumberdaya di dalam kawasan tersebut. Bahkall mcreka seringkali dianggap sebagai ancaman terhadap upaya konservasi dan peiestarian taman nasional. Inilah yang kemudian menyebabkan hubungan antara pengelola dengan masyarakat sekitar menjadi kurang hannonis, dan pada akhirnya dapat memicu konflik kepentingan di antara keduanya.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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