Judul: Analisis Spasial Pola Penggunaan Lahan, Sebaran Penduduk dan Beberapa Indikator Sosial Ekonomi Wilayah Bekasi
Abstrak: Perkembangan penduduk perkotaan (urban) di wilayah pinggiran perkotaan (suburban) antara lain disebabkan perpindahan penduduk kota ke wilayah pinggiran yang mencari .tempat bermukim yang lebih nyaman dan terjangkau. Suburbanisasi merupakan proses berkembangnya wilayah pinggiran kota yang disertai dengan perubahan dan peningkatan aktifitas perekonomian. Bogor-Tangerang-Bekasi (Botabek) sebagai wilayah penyangga Jakarta merupakan pusat kegiatan yang potensial dan strategis. Wilayah Bekasi sebagai salah satu bagiannya dirasakan sangat strategis, dimana wilayahnya merupakan perbatasan langsung dua propinsi besar yaitu Propinsi Jawa Barat dan DKI Jakarta. Akses yang sangat mudah menuju wilayah Jakarta membawa konsekuensi logis berupa limpahan jumlah penduduk yang tidak tertampung di Jakarta.
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Judul: Dinamika Penggunaan Lahan dan Penataan Ruang Kabupaten Bekasi
Abstrak: Bekasi Regency is a strategic area since it shares borders with Jakarta. This gives the inhabitants opportunities directly or indirectly to Jakarta’s economic power. The rapid development implies soaring requirements of space to assist various utilizations such as governmental uses, trade/commercials, services and industry. In Bekasi case, the development has been aided by availability of existing facilities, including road infrastructures. The aims of this research are to assess the dynamics of population and economic growth, spatial arrangement and their relationships to land use changes in Bekasi regency between 1995 and 2009. Methods to achieve the goal include remotely sensed image processing and statistical inquiries which consist of correlation and stepwise regession analysis. This research revealed that main land use alteration involves upland and rice fields and is largely converted to residential, industrial area or other services. Nonetheless, overall changes are insignificant during 15 year of observation. However, it is shown that land use modification tends to occur locally or clustered along Tambun, Cibitung and Cikarang zones, in particular between 2000 and 2006. During 2006-2009 period, the changes spreaded across the residency, except Bojongmangu district. It was found that the main driving factors influencing land alteration in Bekasi Regency are accessibility to road networks, rapidly-growing population, expanding facilities development and space allocation.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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