Judul: Memory Learning and Neurogenesis in Mice Hippocampus Using Big Ginger Oil (Zingiber officinale Rosc.)
Abstrak: Memori spasial erat kaitannya dengan pembelajaran navigasi pada otak yang dipengaruhi oleh neurogenesis. Neurogenesis merupakan proses pembentukan sel saraf yang dapat dipacu salah satunya dengan pemberian antioksidan. Senyawa antioksidan pada jahe gajah salah satunya yaitu gingerol yang memiliki kemampuan memulihkan fungsi otak. Penelitian ini bertujuan menguji pengaruh minyak jahe gajah (Zingiber officinale Rosc.) terhadap kinerja memori dan neurogenesis pada hipokampus. Penelitian dilakukan terhadap 6 ekor mencit yang terbagi ke dalam dua kelompok. Kelompok P100 diberikan minyak jahe gajah 100mg/kg BB dan kontrol diberikan dengan 0,5% Tween 80 selama 30 hari. Uji y-maze alteration dan uji novel object recognition dilakukan untuk mengukur kinerja memori pembelajaran spasial. Mencit dibedah dan diambil otaknya kemudian diwarnai dengan Hematoksilin-Eosin (HE) untuk mengamati Neural Progenitor Cell (NPC), Granulle Cell (GC), dan sel apoptosis. Hasil penelitian menunjukkan bahwa pemberian minyak jahe gajah pada densitas NPC dan granul tidak mengalami peningkatan yang signifikan. Sementara, pada sel apoptosis terjadi penurunan yang tidak signifikan. Pemberian minyak jahe gajah tidak secara signifikan meningkatkan kinerja memori spasial., Spatial memory is closely related to navigational learning in the brain which is influenced by neurogenesis. Neurogenesis is the process of forming nerve cells that can be stimulated, one of which is the provision of antioxidants. One of the antioxidant compounds in big ginger is gingerol which has the ability to restore brain function. This study aims to examine the effect of big ginger (Zingiber officinale Rosc.) oil on memory performance and neurogenesis in the hippocampus. The study was conducted on 6 mice which were divided into two groups. The P100 group was given 100 mg/kg BB big ginger oil and the control group was given 0.5% Tween 80 for 30 days. Y-maze alteration test and novel object recognition test were conducted to measure the performance of spatial learning memory. The mice were dissected and their brains were taken and then stained with Hematoxylin-Eosin (HE) to observe Neural Progenitor Cell (NPC), Granulle Cell (GC), and apoptotic cells. The results showed that the administration of big ginger oil on the density of NPC and granules did not increase significantly. Meanwhile, in apoptotic cells there was an insignificant decrease. Giving big ginger oil did not significantly improve spatial memory performance
Keyword: Apoptotic Cell, Granulle Cell, Neural Progenitor Cell (NPC), Novel Object Recognition Test, Y-Maze Alteration Test

Judul: Neurogenesis and Memory Learning Ability of Mice (Mus musculus) after Geraniol Treatment
Abstrak: Kemampuan pembelajaran memori dipengaruhi oleh neurogenesis. Potensi terjadinya neurogenesis dapat ditingkatkan dengan pemberian senyawa aktif dari salah satu tanaman. Serai (Cymbopogon citratus) memiliki komponen minyak esensial geraniol yang dapat dimanfaatkan sebagai terapeutik neuropati dan agen terapi potensial penyakit Parkinson. Penelitian ini bertujuan menguji pengaruh geraniol pada serai terhadap kinerja memori dan neurogenesis pada hipokampus. Penelitian dilakukan dengan pemberian geraniol secara oral selama 30 hari pada 3 kelompok perlakuan dengan masing-masing kelompok perlakuan terdiri dari 3 ekor mencit (Mus musculus) jantan galur DDY. Kelompok satu (kontrol) diberikan saline 0,9%, kelompok dua diberi geraniol dengan dosis 100 mg/kg BB, kelompok tiga diberi geraniol dengan dosis 200 mg/kg BB. Analisis kinerja memori menggunakan metode Y-maze alternation test dan Novel object recognition test. Otak mencit diambil kemudian dilakukan pembuatan preparat histologi untuk mengamati Neural Progenitor Cell (NPC), sel granular, dan sel apoptosis. Hasil penelitian menunjukkan peningkatan jumlah persentase sel NPC dan sel granular secara signifikan dan menurunkan jumlah persentase sel apoptosis secara tidak signifikan pada kedua dosis. Kinerja memori spasial mencit setelah pemberian geraniol menunjukkan peningkatan yang tidak signifikan. Kinerja recognition memory mengalami penurunan pada dosis kontrol dan dosis 100 mg/kg BB dan mengalami peningkatan pada dosis 200 mg/kg BB., Memory learning ability is influenced by neurogenesis. The potential for neurogenesis can be increased by giving active compounds from one of the plants. Lemongrass (Cymbopogon citratus) has an essential oil component of geraniol which can be used as a therapeutic neuropathy and a potential therapeutic agent for Parkinson's disease. This study aimed to examine the effect of geraniol in lemongrass on memory performance and neurogenesis in the hippocampus. The study was conducted by giving geraniol orally for 30 days to 3 treatment groups with each treatment group consisting of 3 male mice (Mus musculus) DDY strain. Group one (control) was given saline 0.9%, group two was given geraniol at a dose of 100 mg/kg BW, group three was given geraniol at a dose of 200 mg/kg BW. Memory performance analysis using method Y-maze alternation test and Novel object recognition test. The brains of mice were taken and then made histological preparations to observe Neural Progenitor Cell (NPC), granular cells, and apoptotic cells. The results showed a significant increase in the percentage of NPCs and granular cells and an insignificant decrease in the percentage of apoptotic cells at both doses. The performance of the spatial memory of mice after geraniol administration showed an insignificant increase. The performance recognition memory decreased at a control dose and a dose of 100 mg/kg BW and increased at a dose of 200 mg/kg BW.
Keyword: apoptosis, granular, memori spasial, NPC, recognition

Judul: Sifat-sifat Statistika Penduga Turunan Pertama dan Turunan Kedua Fungsi Intensitas Proses Poisson Periodik
Abstrak: This manuscript is concerned with estimation of the first and second derivatives of intensity function of a periodic Poisson process. It is considered the worst condition if there is only available one realization of periodic Poisson process observed in interval [0, n ]. It is assumed that the period of this process is known. The main problem discussed in this manuscript is the formulation of asymptotic approximations to the bias and variance of the estimators for the first and second derivatives of the intensity of the process considered. In addition, computer simulations were carried out to study the behaviour of these asymptotic approximations for finite sample size.
Keyword: