Judul: Konsistensi Rencana Tata Ruang di Kawasan JABODETABEK
Abstrak: Oengan meningkatnya jumlah penduduk maka kebutuhan akan ruang pun akan semakin meningkat, sehingga mendorong berkembangnya penggunaan dan pemanfaatan ruang. Bentuk-bentuk kebutuhan akan ruang adalah kebutuhan untuk pemukiman, pertanian, industri dan pariwisata kemudian akan mendorong berkembangnya penggunaan dan pemanfataan ruang berskala besar di .Tabocletabek (Jakarta, Bogor, Tangerang, Bekasi, dan Oepok). Keadaan ini bisa menimbulkan ketidakkonsistenan pemanfaatan ruang bila pemanfaatannya tidak sesuai dengan arahan pemanfaatan ruang yang ada, inkonsistensi yang terjadi dapat menimbulkan berbagai dampak negatif terhadap lingkungan.
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Judul: Analisis Inkonsistensi Penggunaan Lahan terhadap Rencana Tata Ruang Kawasan dan Kemampuan Lahan (Studi Kasus Jabodetabek)
Abstrak: Jabodetabek is the greatest metropolitan region and the most dynamic region in Indonesia where economic growth is accompanied by a hight rate of demand for housing and other urban facilities. Spatial planning in this region is characterized by inconsistencies that occur between land use/cover, spatial plan as well as land capability. Inconsistencies also occur due to RTR that a lack of attention to environmental carrying capacity, especially land capability. The purposes of this study are: (1) to analyze the land use Jabodetabek in 2010, (2) to evaluate the inconsistencies between land use in 2010 againts the allotment of land according to Jabodetabekpunjur Region Spatial Plan (RTR), President Decree no. 54 year 2008, (3) to evaluate incompatibility of land use in 2010 to land capability, and (4) to evaluate the incompatibility of the allotment of land according to Jabodetabekpunjur Region Spatial Plan (RTR) to land capability criterias. The method of this research is using a combination of overlayed maps in accordance with the parameters and analyzed descriptively. The result showed that there are 11 types of land use of Jabodetabek in 2010 with the largest land use is land use for rice irrigated of 169.156,5 Ha or 26,45%, then settlement area of 157.728,5 Ha or 24,66%. Area of land use that is inconsistent with land allotment of RTR Region of 65.286,0 Ha or 10,21%. The greatest inconsistency on land allotment is occurred in allotment for B-4/HP zone (allotment for B-4 zone that ascertained as fixed production forest sphere or confined production forest sphere according to law regulation), while the land use wich most inconsistent is grove/shrubs. Land use that is not compatible to land capability are 134.874,9 Ha (21,09%) with the greatest incompatibility of land capability are on the land class III and the land use with greatest incompatibility is settlement area. The land allotment of RTR Region that is not compatible to land capability are in wide of 145.657,5 Ha (22,77%). Land capability class with the highest of inconsistency rate are the land classes III and II, while the largest allotment of lands that is not compatible with land capability are occured on allotment for B-2 zone (moderate density settlement) and B-1 zone (hight density settlement).
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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