Judul: Anti-aging Activity of the Skin Cream Formula With Active Ingredients Nanophytosome Extracts From Merbau Wood and Gotu Kola Leaf
Abstrak: Kayu merbau/KM (Intsia bijuga Colebr.) dan daun pegagan/DP (Centella asiatica Linn.) berpotensi dikembangkan sebagai bahan baku krim antipenuaan kulit (antiaging) alami. Penelitian ini bertujuan menentukan rendemen dan fitokimia ekstrak KM dan DP, karakterisasi nanofitosom kombinasi ekstrak merbau:pegagan (MP) dengan nisbah 1:2 (MP1:2) dan 2:1 (MP2:1) serta aktivitas antioksidan dan tebair surya secara in vitro, lalu menguji efektivitas formula krim antiaging secara in vivo. Formula krim berbahan aktif (BA) MP dan nanofitosom (NFMP) yaitu F1 (MP1:2 1,2%), F2 (MP1:2 2,4%), F3 (MP2:1 1,2%), F4 (MP2:1 2,4%), F5 (NFMP1:2 4%), F6 (NFMP1:2 8%), F7 (NFMP2:1 4%), F8 (NFMP2:1 8%), krim tanpa BA (KN), dan krim komersial (KP) diolesi ke kulit mencit jantan selama 14 hari. Rendemen ekstrak KM adalah 19,09% dan mengandung senyawa robinadol, sedangkan rendemen DP sebanyak 30,39% mengandung asiatikosida. Berdasarkan pengujian Fourier Transform Infra Red (FTIR) telah terbentuk fitosom ekstrak MP ditandai dengan menurunnya gugus OH. Antioksidan dan tabir surya in vitro menurun namun meningkat secara in vivo. Krim F5 menghasilkan skor alergi yang rendah, kolagenase yang tinggi dan nilai Grey Value Unit (GVU) tertinggi serta kerutan yang sedikit setelah diberi sinar ultra violet (UV).
Keyword: alergenitas, kecerahan kulit, kerutan, kolagenase

Judul: Physicochemical Stability of Anti-aging Cream Formulas with Active Ingredients of Nanoemulsion and Nanophytosome of Merbau Wood  Extracts and Pegagan Leaf Extracts Combination
Abstrak: Penuaan kulit dapat dicegah dengan menggunakan krim anti-aging, tetapi umumnya berbahan aktif sintetik yang berbahaya dan impor. Nanofitosom dan nanoemulsi kombinasi ekstrak kayu merbau dan daun pegagan (KE) menjadi subsitusinya. Penelitian ini bertujuan menentukan stabilitas sifat fisikokimia empat belas formula krim berbahan aktif KE1:2 (F1:1,2%; F2:2,4%), KE2:1 (F3:4%; F4:8%), nanoemulsi KE1:2 (F5:4%; F6:8%), nanoemulsi KE2:1 (F7:4%; F8:8%), nanofitosom KE1:2 (F9:4%; F10:8%), nanofitosom KE2:1 (F11:4%; F12:8%), kontrol negatif (KN), dan kontrol positif (KP) yang disimpan pada suhu ruang selama 21 hari. Hasil penelitian menunjukkan homogenitas, warna, dan aroma semua formula krim stabil. Kecuali F2 dan F12, kedua belas formula krim memenuhi standar SNI 16-4399- 1996 untuk nilai pH, viskositas, dan daya sebar. Formula krim KP, F3, F4, F5, F6, F7, dan F8 termasuk krim terbaik untuk diaplikasikan pada wajah karena memiliki pH sekitar 4,5-6,5. Penyimpanan selama 21 hari mempengaruhi nilai pH, viskositas, dan daya sebar formula krim tersebut, tetapi masih memenuhi standar SNI 16-4399- 1996., Skin aging can be prevented by using anti-aging creams, but generally using synthetic active ingredients that are dangerous and imported. The combination of merbau woods extract and pegagan leaves (KE) became the substitute. To improve its bioavailability, KE was made into nanophytosome and nanoemulsion. This study aim to determine the stability of the physicochemical properties of fourteen cream formulas with active ingredients KE1:2 (F1:1,2%; F2:2,4%), KE2:1 (F3:4%; F4:8%), KE1 nanoemulsion: 2 (F5:4%; F6:8%), KE2:1 nanoemulsion (F7:4%; F8:8%), KE1:2 nanophytosome (F9:4%; F10:8%), KE2:1 nanophytosome (F11:4%; F12:8%), negative control (KN), and positive control (KP). The creams were stored at room temperature for 21 days. The results showed that all cream formulas' homogeneity, color, and aroma were stable. Except for F2 and F12, the twelve cream formulas met the standards of SNI 16-4399-1996 for the value of pH, viscosity, and spreadability. KP, F3, F4, F5, F6, F7, and F8 cream formulas are among the best creams to be applied to the face because they have a pH value of around 4.5-6.5. The storage for 21 days affected the pH value, viscosity, and spreadability, but they still met the standard of SNI 16-4399-1996.
Keyword: spreadability, homogeneity, organoleptic, pH, viscosity

Judul: Implementation of Spatio-Temporal Change Query in Relational Database.
Abstrak: Geographic object changes in various views. Object changes are recorded using a model of static storage. No historical connection between old version data and new version data has been built. For that, a storage model of spatio-temporal queries that can analyze spatio-temporal changes has been developed. The object changes the geometry are grouped according to the taxonomy of Spatio-Temporal Pattern Change. This research has been able to apply the query patterns change including born, expand, merge, contract, split, normal and die. This query based on geometric (area) changes. The implementation of spatio-temporal change queries represents an object changes continuously with easy, change detection is done by comparing two versions of data. Keyword: spatio-temporal change query, spatio-temporal change pattern.
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