Judul: Toksisitas Akut Ekstrak Daun Sirsak Ratu (Annona muricata) dan Sirsak Hutan (Annona glabra) sebagai Potensi Antikanker
Abstrak: Soursop plants has been known to have pharmacological activities such as anticancer. Soursop species that are widely found in Indonesia are soursop (Annona muricata) and pond apple (A. glabra). This study has determined the toxicity properties of leaf extracts of these species to brine shrimps larvae and zebra fish embryos. Overall, the pond apple extract showed higher toxicity then the soursop. The best LC50 values were obtained from hexane extract of pond apple leaves, namely 197 μg/mL to brine shrimps larvae and 326 μg/mL to zebra fish embryo. These values indicate a significant correlation as anticancer compounds. This extract of pond apple resulted 8 spots in separation by using thin layer chromatography. 1H-NMR measurement towards these 2 well-separated spot did not show acetogenin component, as previously reported as the anticancer components in soursop plants. Further fractionation of the extract is needed to ensure the structure of the anticancer active component it contained.
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Judul: Pencirian Ekstrak Aktif Sitotoksik dari Daun Sirsak Gundul (Annona glabra) Indonesia
Abstrak: Pond apple (Annona glabra) is a member of Annonaceae. It has been reported that plants from Annonaceae family contains alkaloid, flavonoid, and acetogenin having good anticancer potency. The objectives of this research were to fractionate A. glabra leaves assisted with brine-shrimp lethality test (BSLT), to characterize the active extract, and to identify the phytochemical constituents. Fractionation of 95% ethanol extract using liquid-liquid extraction gave 7 fractions, namely yellow, orange, and dark water, chloroform, residue, hexane, and methanol fractions. Based on the BSLT results, chloroform fraction showed the highest activity with LC50 of 98 ppm. Phytochemical test of the most active fraction showed alkaloid, flavonoid, steroid, triterpenoid, and tanin components. Subsequent fractionation of the chloroform fraction by using hexane-CH2Cl2-methanol (90:40:5) eluent produced 16 spots. The infrared spectrum of the best separated spot was analyzed and showed functional groups with -OH, aromatic C=C, C-H sp2, and C-H sp3 bonds.
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Judul: Digital Transformation Model and Strategy in Vocational Higher Education
Abstrak: Vocational education stands out for its practical orientation complemented by relevant theoretical knowledge, distinguishing it from academic education which places greater emphasis on theory. Achieving the right balance between practical application and theory is vital for success in vocational education. Notably, hands-on training takes precedence, making vocational education a unique educational pathway. Using SEM, SSM, and ISM, the study delves into digital transformation strategies categorized into four main elements: Demand & Discovery, Learning Design, Learner Experience, and Work & Lifelong Learning. Each element encompasses critical components, signifying a holistic approach to enhancing vocational education. Demand & Discovery focuses on product strategy, marketing, enrollment management, and student recruitment, crucial for understanding market dynamics and student enrollment processes. Learning Design, pivotal in education, covers curriculum design, digital content creation, and teaching strategies, emphasizing engaging and effective learning experiences. Learner Experience encompasses various facets of the academic journey, including learning environments, support services, and assessment methodologies, highlighting the importance of a nurturing ecosystem. Work & Lifelong Learning centers around work-integrated learning, industry engagement, and lifelong learning pursuits, underlining pathways for seamless integration into the workforce. The proposed approach for Indonesian polytechnics' digital transformation is multi-faceted. It starts with establishing a tech-ready infrastructure through thorough technology assessment, strategic budget allocation, private sector partnerships, and pursuit of grants. Skill Empowerment follows, involving tailored training programs aligned with digital tools and continuous assessment of skill relevance. Internal proficiency, a vital aspect, focuses on providing resources and spaces for continuous development, along with a cultural shift towards hands-on learning and real-world application. Industry integration is promoted to enhance experiential learning, emphasizing open communication and industry advisory boards. Global collaboration and policy advocacy further strengthen the transformation process. Partnerships with international institutions, specialized training programs, and online platforms for professional development broaden educational horizons. Addressing limitations in applied master's and doctoral education is vital. Centers of Excellence and hybrid learning models complete the transformational framework. The Integrated Skill Development Ecosystem (ISDE) emerges as the solution to modern vocational education demands, aligning education with industry needs. It integrates real-world experiences, advanced technologies, and tailored learning paths to produce job-ready graduates adaptable to evolving industries. ISDE fosters collaboration between institutions and industries, driving continuous improvement. Implementing ISDE necessitates adapting curriculum, teaching methods, and digital integration, ultimately benefiting industries and producing a skilled workforce, thereby enhancing competitiveness. ISDE holds significant benefits for industries. Graduates possess industry-specific skills, reducing training costs and accelerating productivity. They are adept in the latest technologies, enhancing adaptability. ISDE encourages innovation, problem-solving, and collaboration, fostering a dynamic workforce. Strong partnerships with educational institutions lead to collaborative projects and research. Employing ISDE graduates provides a competitive edge, addresses skill gaps, and contributes to long-term industry growth and economic development. In summary, ISDE enhances vocational education quality, relevance, and effectiveness, benefiting both students and the broader economy.
Keyword: Digital Transformation, Interpretative Structural Modeling, Soft System Methodology, Structural Equation Model, U Theory, Vocational Higher Education