Judul: Analisis faktor-faktor yang mempengaruhi konversi lahan sawah ke penggunaan non sawah (Studi kasus Propinsi Jawa Barat)
Abstrak: Pada beberapa tahun terakhir ini, luas lahan sawah di Indonesia cenderung menurun sebagai akibat meningkatnya permintaan lahan untuk pernbangunan, seperti perumahan, industri, perkantoran, sarana dan prasarana, dan lain-lain. Menurut Departemen Pertanian (19SS), luas lahan pertanian yang dikonversikan ke penggunaan non pertanian di Indonesia tidak kurang dari 40000 hektar tiap tahun. Angka rata-rata ini meningkat menurut hasil sensus Pertanian 1993 ~nenjadi5 0000 hektar per tahun.
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Judul: Analisis faktor-faktor yang mempengaruhi konversi lahan sawah ke penggunaan non sawah di Kabupaten Cirebon
Abstrak: Lahan merupakan sumberdaya alam yang memiliki fungsi sangat luas dalam memenuhi berbagai kebutuhan manusia. Seiring dengan meningkatnya kegiatan pembangunan dan pertumbuhan penduduk, kebutuhan terhadap lahan semakin meningkat seperti untuk pemukiman, industri serta sarana dan prasarana. Di sisi lain ketersediaan lahan relatif tetap sehingga menyebabkan terjadinya kelangkaan lahan atau kelebihan permintaan. Adanya kelebihan permintaan terhadap ketersediaan lahan, menimbulkan terjadinya persaingan penggunaan lahan yang akan menyebabkan terjadinya konversi lahan.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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