Judul: Senyawa Fitokimia dan Sitotoksisitas Ekstrak Daun Surian (Toona sinensis) Terhadap Sel Vero dan MCF-7
Abstrak: The compounds of surian leaves possess a wide range of pharmacology activity, such as antioxidant and anticancer. The research aimed to analyze phytochemical compounds and cytotoxicity of surian leaves extracts against vero and MCF-7 cells line. Extraction of surian leaves was performed with some solvents, those were water, ethanol 70%, ethyl acetate, and n-hexane. The results showed that highest extracts yield obtained from ethanol 70% followed by water, ethyl acetate, and n-hexane extracts yield were 34.85%, 33.54%, 6.38%, and 1.31% respectively. Surian leaves extracts presence phytochemical compounds of alkaloid, triterpenoid, flavonoid, tanin, phenol, steroid. Highest total phenolic equivalent of gallic acid (GAE) obtained from etanol 70% extracts (500.30 mg GAE/g extract) followed by water (465.30 mg GAE/g extract), ethyl acetat (192.80 mg GAE/g extract), and n-hexane extracts (109.30 mg GAE/g extract). Total flavonoid equivalen of quersetin (QE) water, etanol 70%, ethyl acetat, and n-hexana extracts were 92.10, 62.96, 23.43, dan 12.70 mg QE/g extracts respectively. Results of cytotoxicity assay showed surian leaves extracts were not toxic on vero cells with IC50 value 463.03 (water extract), 197.88 (ethanol 70% extract), 121.09 (ethyl acetat extract), and 217.43 ppm (n-hexane extract). Surian leaves extracts had no anticancer potency against MCF-7 cells with IC50 value of all extracts more than 100 ppm. Based National Cancer Institute (NCI), this value showed low cytotoxicity of surian leaves extracts against MCF-7 cells.
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Judul: Antioxidant, HMG-CoA Reductase Ihibition activity, and Chemical Compound Identification of Surian (Toona sinensis) Leaves Extract.
Abstrak: Surian (Toona sinensis) is forest plant that are widespread in Asia. This plant only used and known as a comodity for carpentry in Indonesia but in other nation surian is known as spices and traditional medicine because of its natural antioxidant potential. The objective of this study was assayed total phenolic content, total flavonoids content, antioxidant activity, HMG-CoA reductase inhibition activity and to analyze chemical compound from Surian leaves extract. Surian leaves were extracted by water and ethanol solvent. Water extraction was conducted by reflux in 90 oC then ethanol extraction was conducted by maceration, which is through various concentration 70%, 80%, 90%, and 96% of ethanol. Total Phenolic content was determined according to the Folin–Ciocalteu method using miligram of gallic acid equivalent and total flavonoid content was evaluated using aluminium chloride by compared with quercetin standard. Antioxidant activity of the water and ethanol extracts was evaluated using DPPH radical scavenging method. Inhibition of HMG-CoA reductase was assayed in vitro using single concentration inhibition with atorvastatin as comparison. Total phenolic and flavonoid content of ethanol 90% extract and ethanol 96% extract had higher amount than the other. The ethanol 96% extract had the strongest DPPH inhibition conccentration 50% (IC50), which is 3.38 μg /mL while ascorbic acid is 3.90 μg /mL as a comparison. The ethanol 96% extract also had highest inhibition HMG-CoA reductase activity which is 79.13% and this activity strongest in water fraction from this extract with inhibition 91.49% while atorvastatin as a comparsion is 92.45%. Antioxidant and inhibition ezyme activity had strong corelaltion with total flavonoid content. Chemical compound by LC-MS assay mostly are counted in the flavonoids group.
Keyword: Antioxidant, Flavonoids, HMG-CoA reductase, Toona sinensis

Judul: Asymptotic Distribution of Estimator for the Intensity Function of a Doubly Periodic Poisson Process
Abstrak: In this manuscript, estimation of the intensity function of a doubly periodic Poisson process is discussed. It is assumed that only a single realization of the Poisson process is observed in a bounded window [0,n]. It is also assumed that the period of the intensity function is known. The rate of consistency and asymptotic normality of the estimator are formulated. Finally, a confidence interval for the local intensity function is also formulated.
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