Judul: Preparation and Characterization of Ketoprofen Coated with Chitosan-Alginate Nanoparticle
Abstrak: Ketoprofen nanoparticle can be used to make a controlled delivery system of ketoprofen. Material composition and preparation method are influent to formation of ketoprofen nanoparticle. The purpose of this research were to produce ketoprofen nanoparticle with variation of chitosan, alginate, and tripolyphosphate (TPP) concentration and to determine the encapsulation efficiency of ketoprofen and the nanoparticle size. Ketoprofen nanoparticles were produced by ultrasonication and sentrifugation methods. Ketoprofen encapsulation efficiency was determined with ultraviolet spectrophotometry analysis and nanoparticle size with scanning electron microscope. The best formula was obtained with the composition of 1.50% (w/v) chitosan, 0.625% (w/v) alginat, and 4.0% (w/v) TPP. The encapsulation efficiency and nanoparticle size were 78.84 % and 26.81 %, respectively.
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Judul: Sintesis, Karakterisasi, Stabilitas Nanopartikel Ketoprofen Berdasarkan Jenis Surfaktan dan Uji Aktivitas Antiinflamasi Secara In Vivo.
Abstrak: In this research, ketoprofen is used as a drug model in the preparation of ihitosan nanoparticles as a potential drug delivery system through ionic gelation wocess with tripolyphosphate (TPP). Suspension stability and characterization of 61itosan nanoparticles-coated ketoprofen prepared by ultrasonication, r+ &ntrifugation, and spray drying were analyzed. §: From the results of Particle Size Analysis, it was shown that the average ~rticle size and polidispersity index of chitosan nanoparticles prepared with oleic i id were 253.7 nm and 0.375 with drug entrapment efficiency of 73.30%, while ~o se prepared with poloxamer 188 were 242.94 nm and 0.302 with drug entrapment efficiency of 87.89%. Scanning Electron Microscopy (SEM) analysis ~owed that the nanoparticles shape, both prepared with oleic acid and poloxamer "lI£8, was intact spherical shape. Fourier transform infrared spectroscopy (FTIR), & wever, indicated several differences between the spectra of chitosan and ~toprofen-loaded chitosan nanoparticles, for example, the peak at wavenumber ~41 cm-1 of ketoprofen-loaded chitosan nanoparticles showed P-OH group of ~P and a new peak at the wavenumber 1409 cm-1 indicated the presence of 'iectrostatic interaction between the carboxyl group of ketoprofen and the amino .group of chitosan. Chitosan nanoparticles suspension prepared with poloxamer 188 showed smaller increase in turbidity and viscosity than that prepared with oleic acid during 34 days of storage both at room temperature and 4°C, which indicates that chitosan nanoparticles prepared with poloxamer 188 is more stable. This stability characteristic is suggested from agglomeration occurred in both chitosan nanoparticles suspensions. Anti-inflammatory activity test of chitosan nanoparticles-coated ketoprofen was perfonned by obeserving the capability to reduce the swelling, or oedema, as a result of injection of 1 % karagenin on the foot pad of rats. The results of the test owed that chitosan nanoparticles-coated ketoprofen had anti-inflammatory ,S¢tivity comparable to the activity of the positive control (uncoated ketoprofen) in ~e same dosage dose, i.e. 43.92% vs 49.90%, after 5 hours of injection .
Keyword: Chitosan, ketoprofen, nanoparticles, oleic acid, poloxamer 188

Judul: Potensi Burung Air Liar sebagai Atraksi Wisata di Taman Rekreasi Margasatwa Serulingmas Banjarnegara
Abstrak: Taman Rekreasi Margasatwa Serulingmas (TRMS) sebagai kawasan konservasi juga memiliki fungsi sebagai ruang terbuka hijau yang memiliki manfaat secara ekologis sebagai habitat bagi tumbuhan dan satwaliar. Lokasinya yang berdekatan dengan sungai serayu juga menjadikan TRMS sebagai habitat bagi burung air liar. Penelitian ini dilakukan untuk menggali potensi burung air liar sebagai atraksi wisata dan mendesain media interpretasi mengenai burung air liar guna meningkatkan edukasi bagi pengunjung. Metode yang digunakan dalam pengambilan data burung yaitu metode jelajah dan concentration count untuk menghitung jumlah individu dan melihat aktivitas. Sebanyak 100 pengunjung ditentukan menggunakan convenience sampling untuk mengetahui minat terhadap burung air dan media interpretasi. Kowak malam kelabu dan blekok sawah memiliki potensi sebagai atraksi wisata karena mudah diamati. Hal yang mendasari pemilihan jenis tersebut dikarenakan ukurannya yang besar (≥ 45cm), berkoloni dan berdiam diri. Cekakak jawa juga berpotensi sebagai atraksi wisata karena keunikan serta statusnya yang dilindungi pemerintah.Sebanyak 83% responden berminat terhadap atraksi burung air liar. Media interpretasi yang diminati oleh pengunjung adalah peta persebaran dengan peminat sebanyak 53%. Bentuk yang dapat dipilih berupa papan interpretasi, poster dan brosur.
Keyword: atraksi wisata, burung air liar, media interpretasi, Taman Rekreasi Margasatwa Serulingmas