Judul: Fenotipe domba lokal di unit pendidikan penelitian dan peternakan Jonggol
Abstrak: This research was a comparative study of qualitative and quantitative characters of local sheep at UP3J (Jonggol Animal Science Teaching and Research Unit) in 1992 and 2006. The research was conducted from March up to the end of April 2006. The number of observation sheep were 242 heads. It was grouped based on sex and age. Analyzed of body dimensions were description and regression analysized. The percentage of body color patterns were calculated.
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Judul: Studi keragaman fenotipik dan pendugaan jarak genetik antar domba lokal di Indonesia
Abstrak: This research was to study the morphological characteristic and estimating the genetic distance between local sheep in Indonesia with discriminant and canonical analyses. Observed sheep breeds were thirrtailed sheep from Jonggol (Bogor), Gamt sheep h m Ma~gawati (West Java) and fat-tailed sheq, h m Madura Island, Lndramayu (Central Java), Sumbawa Island, Rote Island, Kisar Island (Maluku) and Donggala Island. The number of sheep were randomly collected h m local farmers for 533 heads and h m unit of ranch was 285 heads. Body dimension studied were body weight, body length, wither height, chest width, chest depth, chest circumference, skull length, skull width, skull height, tail lenght, tail width, ear length and ear width.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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