Judul: Studi Histopatologi Potensi Radioprotektif Ekstrak Kelopak Bunga Rosela (Hibiscus sabdariffa L.) dalam Radiasi Ionisasi Radiodiagnostik Berulang pada Lambung Mencit (Mus musculus
Abstrak: The aim of this study was to determine the radioprotective effect of calyx Roselle (Hibiscus sabdariffa L.) extract in recurrent radiodiagnostic ionizing radiation on the gastric of mice (Mus musculus). Fourty eight adult males of mice were used and divided into 4 groups: control (K-), radiation (K+), roselle without radiation (R-) and roselle with radiation (R+). Mice were treated with 50 mg/kg of body weight orally of Roselle extract every two days prior to recurrent irradiation for 4 and 8 weeks. The mice were euthanized by overdose Ketamine and then necropsied followed gastric collection at various time points after irradiation. Sample of gastric were processed to prepare histopathology slides with Haematoxylin-Eosin stain. The changes on the gastric alterations were studied by count the amount of parietal, chief cells and infiltration of inflammatory cells after whole body irradiation. Quantitative data were analysed with ANOVA test and followed by Duncan test. Radiation during 4 week produce total radiation 2.9 mSv and 8 week produce 5.3 mSv. The result showed that Roselle extract was protect parietal and chief cells from radiation effect by recurrent radiodiagnostic ionizing radiation. Roselle extract also inhibiting inflammation process by decreasing necrosis in parietal and chief cells. Administration of Roselle extract significantly (p<0.05) reduced the bioeffects of radiation. Roselle could be useful as natural radioprotector against ionizing radiation
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Judul: Studi Histopatologi Potensi Radioprotektif Ekstrak Kelopak Rosela (Hibiscus sabdariffa L) terhadap Duodenum Mencit (Mus musculus) dengan Radiasi Ionisasi Radiodiagnostik Berulang
Abstrak: This study was conducted to find out the potency of Roselle (Hibiscus sabdariffa L.) as radioprotective against recurrent effect of radiodiagnostic radiation on duodenum of mice (Mus musculus). This research was to observed histophatological changes on duodenum of mice treated with roselle calyx extracts and radiation. Twenty four male mice were used in this study. They were divided into 4 groups namely control group (K) treated with 0.2 ml of NaCl 0.9 % (saline); primary radiation group (P) treated with 0.2 ml of NaCl 0.9 % (saline) and radiation 0.2 mSv; roselle group (R) treated with 0.2 ml roselle calyx extract; and primary radiation-roselle group (RP) treated with 0.2 ml roselle calyx extract and radiation 0.2 mSv. All treatments were done orally every two days for 8 weeks. Afterwards, 3 mice from each group were euthanized for organ sampling. The rest of mice were took 4 weeks of recovery. Afterwards, all mice were euthanized for organ sampling. Duodenum were fixed in Buffered Neutral Formaline (BNF) 10%, embedded in paraffin, then stained with hematoxyline and eosin (HE) and periodic-acid schiff (PAS). The result showed that RP group had lower demage of intestinal villi and numbers of goblet cell than P group. Lieberkühn crypt number of P group was increased, whereas intestinal villi height was decreased compared to R and RP groups. Roselle calyx extract (Hibiscus sabdariffa L.) showed radioprotective potency after radiation treatment on duodenum of mice.
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Judul: Basis of Social Theories for Social Enterprises: Integrative Literature Review
Abstrak: Social enterprise is a hybrid organization aiming to achieve economic and social values that exist as an effective mechanism for creating value in the form of society, economy and environment. The development of social enterprise is considered to have contributed in increasing innovation as well as being a mechanism for ensuring economic development that is in line with social justice. However, the development of theory and study of social enterprise is still lagging behind in practice. The social enterprise conception is a conception that is still considered as a "young term" category in the social sciences and has not shown clear consistency linking social theories to the development of social enterprise. This study aims to identify the basic theories of social enterprise and social theories for social enterprise with used an integrated literature review approach with data sources from Scopus and ProQuest. The results of the study found that socio-economic theory is the basis for social enterprise theory. This study also found the linkages of 7 social theories for social enterprise and the mapping of social theory architecture for social enterprise which is studied on classical and contemporary social theories.
Keyword: integrative literature review, social economic, social enterprise, social theory