Judul: Formula Campuran 3 Daun Tanaman Obat sebagai Penghambat Tirosinase serta Sidik Jari Kromatogramnya
Abstrak: Potensi formula campuran 3 daun tanaman obat (A, B, dan C) dalam mengurangi hiperpigmentasi kulit ditetapkan berdasarkan aktivitas inhibitor tirosinase dan antioksidan. Daun diekstraksi dengan maserasi menggunakan etanol 50%. Ketiga ekstrak tanaman dikombinasikan berdasarkan bobot menggunakan simplex centroid design. Formula diuji kadar fenolik total, flavonoid, aktivitas inhibitor tirosinase, dan antioksidan 2,2-difenil-1-pikrilhidrazil (DPPH). Ekstrak tunggal daun A menunjukkan aktivitas terbaik sebagai inhibitor tirosinase (IC50 monofenolase 214.39 μg/mL; IC50 difenolase 274.40 μg/mL) dan antioksidan (IC50 56.94 μg/mL). Ada 4 noda aktif dengan substrat L-tirosina dan 3 noda aktif dengan substrat 3,4-dihidroksifenilalanina (L-DOPA) yang diperoleh dari pola sidik jari kromatografi lapis tipis ekstrak tunggal daun A. Sidik jari ekstrak tersebut dianalisis menggunakan etil asetat:kloroform sebagai fase gerak terbaik.
Keyword: antioksidan, hiperpigmentasi, inhibitor tirosinase, sidik jari

Judul: Aktivitas antijerawat formula campuran temu lawak dan meniran serta penentuan sidik jari kromatografinya
Abstrak: Anti-acne activity of extracts from C. xanthorriza and P. niruri has been analyzed through antioxidant and antibacterial activity assays. Extraction process was conducted by two different maceration methods, Indonesian and traditional chinese medicine (TCM) with ethanol 96% as the solvent. Formula 6 (2/3 C. xanthorriza:1/6 P. niruri:1/6 starch) was the most active anti-acne formula with IC50 of antioxidant values of 93.17 ppm, the minimum inhibitory concentration against Staphylococcus epidermidis was 0.25 mg/mL, and the minimum bactericidal concentration was 0.50 mg/mL. Moreover, TCM maceration was better than the Indonesian method in terms of antioxidant and antibacterial activities. Fingerprint analysis of formula was undertaken using thin layer chromatography. The optimum mobile phase was chloroform that gave 9 bands. Further, the (HPLC) analysis with C18 as column and gradient of acetonitrile and water as the mobile phase showed that the peak area of phyllanthin and curcumin increased when the standard compounds were added into the sample.
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Judul: Implementation of Spatio-Temporal Change Query in Relational Database.
Abstrak: Geographic object changes in various views. Object changes are recorded using a model of static storage. No historical connection between old version data and new version data has been built. For that, a storage model of spatio-temporal queries that can analyze spatio-temporal changes has been developed. The object changes the geometry are grouped according to the taxonomy of Spatio-Temporal Pattern Change. This research has been able to apply the query patterns change including born, expand, merge, contract, split, normal and die. This query based on geometric (area) changes. The implementation of spatio-temporal change queries represents an object changes continuously with easy, change detection is done by comparing two versions of data. Keyword: spatio-temporal change query, spatio-temporal change pattern.
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