Judul: Aktivitas Antioksidan Nanokurkuminoid Temulawak Lokal Ciemas Pada Tikus Sprague-Dawley Betina
Abstrak: Java turmeric (Curcuma xanthorrhiza) is a typical Indonesian plants that have antioxidant activity. Clinical testing showed that curcumin safe at high doses (12 g/day) but has low bioavailability. Delivery systems by making of solid lipid nanoparticles made to improve bioavailability of curcuminoids. This study aims to measure antioxidant activity of nanocurcuminoid coated solid lipid in female rat induced by CCl4. Analysis of antioxidant activity by measuring Malondialdehyde (MDA) levels and activity of superoxide dismutase (SOD), gluthatione peroxidase (GPX) and peroxidase (POX). Nanocurcuminoids size that obtained was 114.4±33.8 nm with polydispersity index 0.218 and adsorption efficiency 79%. The results showed that administration of nanokurkuminoid dose of 1500 mg/kg in female rats induced by CCl4 were able to reduce levels of MDA (4.34 nmol/mL) and increasing the activity of SOD (64.70 %), GPx (3208.02 mU/mL) and POX (3.13 mU/mL). These results indicate nanokurkuminoid have antioxidant activity.
Keyword: SLN., nanocurcuminoid, female sprague-dawley, CCl4, antioxidant

Judul: Status Antioksidan Tikus Jantan Diinduksi CCl4 dengan Perlakuan Nanopartikel Kurkuminoid Temulawak Lokal Ciemas
Abstrak: Java turmeric (Curcuma xanthorrhiza) is a typical Indonesian plants that has antioxidant activity. Clinical testing showed that curcumin is safe at high doses (12 g/day) but has low bioavailability. This study aimed to measure the increase curcuminoids bioavailability through nanoparticle curcuminoids effectiveness as an antioxidant in rats induce CCl4. Nanoparticle curcuminoids was produced with homogenization-ultrasonication method, after that 27 male rats were divided into 9 groups that will be measured the liver antioxidant activity. The nanoparticle curcuminoids product showed good results with the adsorption efficiency 79% and a particle size 114.4 ± 33.8 nm with IP value 0.218. Generally, the condition of each group of rats did not showed behavior and other physiological symptoms disorder. The best formula from antioxidant status analysis demonstrated 1500 mg dose of nanoparticles can suppress oxidative stress conditions caused by CCl4 administration through decreased levels of MDA and GPx activity and increased activity of SOD and peroxidase than other groups
Keyword: nanoparticle., java turmeric, curcuminoids, bioavailability, antioxidant

Judul: Hamiltonian formulation for linear waves motion in two layers fluid
Abstrak: The surface wave could be considered as a wave that separates two fluids, namely water and air. Based on this assumption, it is introduced the interfacial wave, a wave between two layers of fluid with different density. The formulation of interfacial waves motion begins with deriving the base equation of irrotational ideal fluid. Furthermore, according to irrotational fluid assumption, the base equation can be stated in velocity potential. In this derivation, the fluids domain is assumed to be restricted by rigid lid boundary conditions, both at the upper and lower limit. Therefore, the interfacial waves motion can be explained in a hamiltonian formulation. In the hamiltonian formulation, total energy is defined as the sum of kinetic and potential energy. The hamiltonian system is obtained from reduction of kinetic energy by using the Dirichlet Neumann Operator. The resulted kinetic energy equation is nonlinear. Therefore, this form is linearized by first part of the Taylor expansion. This linearization gives a dispersion relation of linear wave. Based on this dispersion relation, the phase speed of the linear wave depends on the density ratio of the two layers fluid.
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