Judul: Kajian Penerapan Metode Permukaan Respon Pada Formula Jamu Antidiabetes Dengan Ikan Zebra (Danio Rerio) Sebagai Hewan Uji
Abstrak: Jamu adalah obat tradisional terbuat dari bahan alami tumbuhan berkhasiat. Jamu yang baik adalah jamu yang memiliki komposisi pas. Secara statistik komposisi ini dapat ditentukan dengan mencari titik optimum yang diperoleh menggunakan metode permukaan respon (MPR). Penelitian ini bertujuan mencari titik optimum menggunakan MPR pada kombinasi formula jamu antidiabetes. Formula ini terdiri atas 4 peubah bebas tanaman yaitu sembung (X1), pare (X2), rimpang jahe (X3), dan bratawali (X4) serta satu peubah respon (Y) yaitu rata-rata selisih penurunan kadar gula darah ikan zebra. Perhitungan awal untuk mendapatkan model orde pertama menggunakan tiga peubah bebas X1, X2, dan X3. Model ini merepresentasikan hubungan antara peubah X dan peubah Y yang berbentuk linier. Model orde kedua selanjutnya ditentukan dan diuji kelayakan modelnya. Berdasarkan model orde kedua yang layak dengan nilai R-Square 74%, diperoleh titik optimum berada pada kombinasi X1 sebesar 8.08%, X2 sebesar 7.51%, X3 sebesar 34.15%, dan X4 sebesar 50.26%. Titik optimum X4 merupakan sisa proporsi dari ketiga titik optimum X1, X2, dan X3.
Keyword: antidiabetes, formula jamu, metode permukaan respon, titik optimum

Judul: Pendekatan Bioinformatika Formulasi Jamu Baru Berkhasiat Antidiabetes dengan Ikan Zebra (Danio rerio) sebagai Hewan Model
Abstrak: Jamu composition was formulated without any provision like Traditional Chinese Medicine. Recent studies showed regularity pattern through statistical database. Jamu formulations in this study were made using Design Expert and its efficacy predicted using models partial least square discriminant analysis (PLSDA), coefficient PLSDA multiways, and Support Vector Machine. The prediction indicated that 4 plants used were sembung, pare, ginger, and bratawali. The efficacy was verified using zebrafish (D. rerio) as an animal test. Hyperglycemia in the fish was induced by soaking them in alloxan 0.1% for 10 min, glucose 1% for 10 min, and distilled water for 60 min in sequence. One-way t test showed that the increasing blood sugar levels was not significant (p>0.05). These results confirm that the induction process have not been successful to increase the average blood sugar levels. Application of jamu into the fish was done for 3 days after the induction. Statistical observation for all compositions of jamu showed that group 1 has the greatest decline difference.
Keyword: zebrafish, jamu, bioinformatic of jamu, antidiabetic

Judul: Thermal Characteristics and Dynamics of Tropical Cyclone over Western North Pacific Ocean: A Case Study of Typhoon Songda (Chedeng) 2011
Abstrak: The frequent occasion of Tropical Cyclone (TC) over Western North Pacific (WNP) Ocean lies from 10˚N to 26˚N and 121˚E to 170˚E. Sources of TC development come from warm ocean temperature where latent heat is released during condensation processes and subsequently concentrated in the boundary layer. Relative humidity at 850-700 hPa is responsible to produce the most intense storm. Meanwhile, weak vertical wind shear between 850-200 hPa is one of the dynamical factors that lead to the development of TC. Pressure level of 850-200 hPa is chosen to minimize the thermodynamic effect in the lower troposphere. Typhoon Songda (Chedeng in the Philippines) or TSC lasted from May 18th to 30th, 2011 and strengthened into powerful Super Typhoon stage between May 24th and 27th. Long curving track and the exhibition of all sequences of TC life cycle, TSC is then considered as an ideal case of TC. The objective of the study with case of TSC is to investigate the role of thermal characteristics and dynamics on TC intensity. The research is carried out by using Advanced Research of Weather Research and Forecasting model (WRF ARW model) version 3.3. Two domains are employed in the model. The first domain situate from 02˚N to 40˚N and 118˚E to 149˚E and cover spatial resolution () of 33.1 km. The second domain situate from 09˚N to 27˚N and 119˚E to 132˚E with of 11 km. Timestep of the model () is 120 seconds. The model is supported by the following physical parameterization, i.e., Yonsei University Scheme (YSU) in the boundary layer, Kain-Fritsch scheme (KF) in the cumulus, and WRF Single-Moment 3-class scheme in the microphysics. Initial meteorological condition prior to the formation of the cyclone is generated using WRF ARW standard-release model. Sensitivity of the model output is obtained from a selected single-parameter change scenarios, namely, 10 % to 20 % decrease and increase of wind shear initial data at 850-200 hPa, and by 10 % to 20 % decrease of relative humidity initial data at 850-700 hPa. The result showed that the negative correlations between wind shear and intensity are found in wind shear scenarios. Wind shears of 10 ms-1 which lead to strengthening of the wind intensity in the early period of Typhoon development are found in wind shear scenarios. The effect of wind shear changes on wind intensity is statistically significant in the 20 % wind shear scenarios. During mature stage, weak wind intensity occurred when wind shear increase as given in the WRF standard-release and the 20 % decreasing scenario. Different situation is found in the 20 % increasing scenario where wind shear tend to weak and lead to strong wind intensity at this stage. Meanwhile, the reduction of moisture supply at 850-700 hPa resulting from 20 % decreasing relative humidity play a major role in the weakening of wind intensity and reduces mechanical energy of the cycle process as much as 300 J kg-1.
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