Judul: Hipertrofi Kordis pada Monyet Ekor Panjang (Macaca fasicularis) Pasca Obes Induksi Diet Obesitogenik Diikuti Asupan Nikotin
Abstrak: The aim of this study was to examine the evidence of left ventricular hypertrophy of male cynomolgus macaque (Macaca fascicularis) as animal model of human obesity and atherosclerosis. The animals were fed obesitogenic diet for 12 month and treated by per-oral nicotine liquid for 3 month. The objective of this study is exploring the macroscopic aspect of fatty heart enlargement and its compensation. Almost of fifteen samples of hearts showed varies level of fatty deposition and blunted apex. Heart muscle thickening was measured on distal transversal one centimeter’s cutting using caliper with two decimal precision. Relative Wall Thickness (RWT) was measured by calculating Septal Wall Thickness (SWT) that added by Posterior Wall Thickness (PWT) and divided by Left Ventricular Internal Diameter (LVID). All of the heart mostly have concentric type of hypertrophy with elevation of RWT (1.87 ± 1.47 centimeter) compare to the normal one (0,45 centimeter). This RWT has low relations to body weight (r = 0.060) and body mass index (r =0.054). This study refilled that cynomlgous macaque can be developed as animal model of ventricular hypertrophy as a part of alternative solution of ventricular hypertrophy in conjunction with endemic obesity on urban society. This study suggested that the study of nicotine effect on ventricular hypertrophy should be conducted microscopically.
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Judul: Fenomena Peradangan Kardio-Obesitas Pada Monyet Ekor Panjang (Macaca Fascicularis) Jantan Dewasa Dengan Induksi Diet Obsitogenik
Abstrak: Pola hidup masyarakat dengan konsumsi makanan tinggi kolesterol dan karbohidrat akan meningkatkan resiko sindrom metabolik, seperti obesitas. Obesitas adalah faktor utama penyebab penyakit kardiovaskular dan peradangan yang dapat menyebabkan aterosklerosis serta akumulasi sel-sel radang pada sekitar pembuluh darah. Respon peradangan yang disebabkan oleh kardio-obesitas pada pembuluh darah aorta diteliti pada monyet ekor panjang jantan dewasa (Macaca fascicularis) (n=11) menggunakan standar penilaian kuantitatif histologis. Respons peradangan ini diamati pada monyet obesitas yang disebabkan oleh asupan diet obesitogenik selama 15 bulan (n=9) dibandingkan dengan monyet obesitas yang disebabkan konsumsi pakan monyet dalam jumlah tak terbatas (ad-libitum) (n=2). Fenomena ini bisa digunakan sebagai gambaran mikroskopis kardio-obesitas pada monyet sebagai hewan model penyakit kardiovaskular. Respon peradangan lebih rendah pada monyet yang diberi asupan diet obsitogenik diikuti intervensi nikotin cair dosis rendah selama tiga bulan. Studi kasus ini menunjukkan bahwa nikotin cair dosis rendah memiliki efek hambat pada respon peradangan kardio-obesitas.
Keyword: Macaca fascicularis, obesitas, respon peradangan, nikotin cair dosis rendah

Judul: Formulasi TSP (Traveling Salesman Problem) menggunakan ILP (Integer Linear Programming)
Abstrak: TSP is a journey of salesman f?om his origin town (place) to visit n-cities (places) only at once, then return to his origin town (place) with a minimum total distance. Its purpose is to minimize the operating expense that is released by the company. Vehicle route at TSP in the form of a Hamiltonian cycle, that is closed path containing all nodes at the graph which representing a network walk. Its problem is to determine a journey route which is feasible (possibly can be passed by) in such a way the vehicle travelled distance passed the route is minimum.
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