Judul: Khasiat antioksidasi ekstrak kulit kayu mahoni (Swietenia macrophylla King) terhadap peroksidasi lipid pada hati tikus hiperurisemia
Abstrak: The bark of mahogany (Swietenia macrophylla King) contains bioactive compounds, which has been reported as an antioxidant. But there had been very few in vivo evidence of the antioxidant effectiveness on the liver lipid peroxidation in hyperuricemic rats. This study aimed to test the effect of mahogany (Swietenia macrophylla King) bark extracts against lipid peroxidation in hyperuricemic rat liver. Thirty three rats were divided into 5 groups, namely normal, hyperuricemic (HU), allopurinol (HU I), aqueous extract (HU II) and methanol extract (HU III). Hyperuricemic induction was carried out by giving the juices of chicken liver and sodium carboxyl methyl cellulose 0.5%. The induction was administered orally for 4 weeks with dosage of 25 g/kg BW. Afterwards, rat were administered by aqueous extract and methanol extract at 500 mg/Kg BW day for 7 days. Liver lipid peroxides analysis was determined by using thiobarbituric acid (TBA) method. The results showed that the lipid peroxide concentrations of hyperuriemic, allopurinol and methanol extracts group were 101.51 ± 54.74 nmol/gram, 108.55 ± 45, nmol/g and 101.04 ± 26.68 nmol/gram, respectively. The aqueous extract has the antioxidants effect on rat liver lipid peroxidation with the concentration of 63.57 ± 16.84 nmol/g, smaller than that of the normal group (93.83 ± 29.55 nmol/gram). Statistically, the aqueous extract tend to decrease the liver lipid peroxide concentration of hiperuricemic rat by 32.25% (p = 0.054).
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Judul: Penghambatan Peroksidasi Lipid oleh Ekstrak Kulit Batang Mahoni (Swietenia macrophylla King) pada Tikus Hiperurisemia
Abstrak: Increased blood uric acid (hyperuricemia) has been reported in the increased of lipid peroxidation. To overcome lipid peroxide formed, natural antioxidant compounds could be used, one of them is mahony bark extract. The purposes of this research are to analyze lipid peroxidation level and to determine the effect of mahony bark extract on blood lipid peroxide concentration in hyperuricemic rats. A total of 33 rats divided into 5 groups consist of normal control, hyperuricemic control (HU I), allopurinol (HU II, 3.3 mg/Kg BB), HU and water extract (HU III, 500 mg/Kg BB), and HU and methanol extract (HU IV, 500 mg/Kg BB). Hyperuricemia was induced by chicken liver juice fed in 28 days, thus, extract were given everyday in 7 days after, furthermore experiment was done in 35 days. Serum lipid peroxide concentration was analyzed in day-0, 14, 21, 28, and 35 using spectrophotometry method at 532 nm. The result of this research showed that average lipid peroxide concentration of all rats before experiment is 0.586±0.177 nmol/mL. Hyperuricemic induction had increased lipid peroxide concentration up to 11.23%. There was an increased of 11.41% after supplementation of allopurinol, on the contrary water extract could decrease blood lipid peroxide concentration over 26.86% (p= 0.006).
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Judul: Analisis Struktur Atas Gedung Diploma IPB terhadap Beban Gempa Berdasarkan SNI 03-1726-2002 dan SNI 03-1726-2012
Abstrak: Gedung Diploma IPB masih menggunakan SNI 03-1726-2002 dalam perencanaan strukturnya. SNI tersebut kemudian diubah seiring dengan keluarnya peraturan baru yang termuat dalam SNI 03-1726-2012. Tujuan dari penelitian ini adalah mengetahui ketahanan struktur atas gedung Diploma IPB terhadap beban gempa ditinjau berdasarkan waktu getar alami dan partisipasi massa, mengetahui besarnya gaya geser dasar seismik, dan membandingkan besarnya simpangan berdasarkan kedua SNI. Partisipasi massa arah X yang dihasilkan yaitu sebesar 0.9417 pada modal ke 9 dan 0.9006 pada modal ke 12 pada arah Y. Kedua nilai tersebut telah memenuhi kedua standar SNI. Waktu getar alami telah memenuhi standar SNI 2002, namun belum memenuhi standar SNI 2012. Gaya geser dasar dinamik yang dihasilkan berdasarkan SNI 2012 sebesar 1599.6606 kN akibat gempa arah X dan 1223.5794 kN akibat gempa arah Y, sedangkan berdasarkan SNI 2002 untuk arah X sebesar 1544.5109 kN dan untuk arah Y sebesar 1544.8304 kN. Simpangan antar lantai telah memenuhi persyaratan kedua standar SNI. Struktur Gedung Diploma IPB telah memiliki kekakuan yang cukup dan terhitung boros, sehingga seharusnya dapat direncanakan dengan lebih hemat biaya.
Keyword: beban gempa, gaya geser dasar, simpangan, struktur atas