Judul: Preparation and Characterization of Ketoprofen Coated with Chitosan-Alginate Nanoparticle
Abstrak: Ketoprofen nanoparticle can be used to make a controlled delivery system of ketoprofen. Material composition and preparation method are influent to formation of ketoprofen nanoparticle. The purpose of this research were to produce ketoprofen nanoparticle with variation of chitosan, alginate, and tripolyphosphate (TPP) concentration and to determine the encapsulation efficiency of ketoprofen and the nanoparticle size. Ketoprofen nanoparticles were produced by ultrasonication and sentrifugation methods. Ketoprofen encapsulation efficiency was determined with ultraviolet spectrophotometry analysis and nanoparticle size with scanning electron microscope. The best formula was obtained with the composition of 1.50% (w/v) chitosan, 0.625% (w/v) alginat, and 4.0% (w/v) TPP. The encapsulation efficiency and nanoparticle size were 78.84 % and 26.81 %, respectively.
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Judul: Model Kinetika Reaksi Nanopartikel Ketoprofen Tersalut Gel Kitosan-Alginat Berdasarkan Uji Disolusi secara In Vitro.
Abstrak: Modification of chitosan gel by natural hydrogels such as alginate with trypolyphosphate (TPP) crosslinker are potential to be applied as good coating materials in drug delivery system. Most of the drug delivery system studied, however still in micro size. Therefore in this study, chitosan-alginate gel with TPP crosslinker was used to coat ketoprofen in nanocapsules by using spray drying method with variation of chitosan, alginate, and TPP concentration. The kinetic reaction model was determined based on in vitro dissolution test. The size of nanoparticles obtained in this study was about 220–8857 nm. The dissolution test showed that ketoprofen coated by chitosan-alginate crosslinked with TPP had controlled release in acid medium and maximum release in base medium. In general, the ketoprofen releasing kinetic model followed Higuchi, Korsmeyer- Peppas, and Hixson-Crowell equations.
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Judul: Ekologi merak hijau jawa (Pavo muticus muticus) Linnaeus 1758 pada beberapa tipe habitat di Ujung Timur Penyebarannya Jawa Timur, Indonesia
Abstrak: Merak hijau jawa merupakan salah satu jenis burung yang dilindungi.di Indonesia berdasarkan SK Mentan No 66/Kpts/Um/2/1973 dan Peraturan Pemerintah Republik Indonesia No 7 tahun 1999. Menurut ICBP (The International Council for Bird Preservation) merak hijau sebagai jenis burung yang tergolong terancam secara keseluruhan (globally threatened) baik populasi maupun habitatnya, sedangkan CITES mencantumkan merak hijau ke dalam Appendix II, merak hijau dari alam tidak bisa langsung diperdagangkan dan BirdLife International (2007) memasukkan golongan burung yang endangered. Tekanan terhadap populasi dan habitat merak hijau jawa sangat besar, sehingga kondisi populasinya menurun pada setiap penyebaran lokalnya, habitatnya terfragmentasi bahkan terisolasi. Tekanan terhadap populasi terutama karena perburuan liar. Namun demikian fakta menunjukan bahwa merak hijau jawa masih ada (exist), hal ini memberikan gambaran bahwa burung ini tentunya memiliki strategi ekologi tertentu untuk tetap bertahan hidup di alam pada berbagai tipe habitat.
Keyword: Pavo muticus muticus, Call count transect method, Pavo cristatus, Pavo muticus, Pavo muticus spicifer, Pavo muticus imperator, Pavo muticus muticus, Javan Green Peafowl, East Java