Judul: Dampak Pembangunan Perumahan terhadap Aspek Sosial ekonomi Petani (Studi Kasus Desa Padasuka dan Pagelaran Kecamatan ciomas, Kabupaten Bogor)
Abstrak: Skripsi ini ditulis berdasarkan pemikiran bahwa telah terjadi dilema pembangunan perumahan. Di satu sisi pemerintah dihadapkan pada upaya penyediaan perumahan sebagai akibat pertambahan jumlah penduduk. Di sisi lain, pembangunan perumahan membawa konsekuensi bekurangnya lahan pertanian untuk kegiatan non-pertanian. Hal ini berarti telah terjadi perubahan pola pemanfaatan lahan yang mengakibatkan perubahan aspek sosial ekonomi pada masyarakat yang lahannya digunakan untk lokasi pembangunan perumahan maupu masayarakat sekitarnya.
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Judul: Dampak Kawasan Industri terhadap Aspek Sosial Ekonomi Masyarakat (Kasus Desa Karang Asem Timur dan Sentul, Kec. Citeureup, Kab. Bogor)
Abstrak: Pembangunan sektor industri merupakan salah satu alternatif untuk meningkatkan kesejahteraan masyarakat, karena pembangunan industri akan menciptakan berbagai lapangan kerja baru. Perubahan akibat pembangunan industri, selain mendatangkan kesejahteraan bagi masyarakat juga memberi pengaruh terhadap komponen fisik, sosial ekonomi dan sosial budaya.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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