Judul: Kajian Keterkaitan Perubahan Penggunaan Lahan Dengan Pertumbuhan Ekonomi Di Wilayah Jabotabek Tahun 1990-2000
Abstrak: Jabotabek region is considered to be the center of national activities which characterized by its high rate of spatial interaction within the region and very high population density. The high population and economic growth cause significant increase on land demand. It will cause agricultural land use conversion to industrial and housing uses.
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Judul: Analisis pola spasial penggunaan lahan dan suburbanisasi di kawasan Jabotabek periode 1992 - 2000
Abstrak: Tujuan dari penelitian adalah mengembangkan model empiris pola dan laju perubahan spasial penggunaan lahan urban di kawasan Jabotabek dalam kurun waktu 1992 – 2000 dan memperoleh informasi keterkaitan spasial pada perkembangan penduduk dengan pola penggunaan lahan urban Jabotabek. Pertumbuhan penduduk yang tinggi di Jakarta akan menyebabkan tekanan – tekanan penggunaan lhan untuk dijadikan pemukiman ke daerah pinggiran (suburban) Jakarta yang semakin kuat. Hal ini disebabkan karena semakin sempitnya ruang dan mahalnya harga lahan di Jakarta. Kejadian ini sudah terjadi mulai tahun 1990 dimana DKI berubah menjadi pemberi yang ditandai dengan migrasi netto minus dengan pola yang semakin meningkat sampai dengan tahun 1995. Akibat secara langsung adalah konversi lahan yang tinggi untuk kebutuhan pemukiman dan industri maupun infrastruktur (lahan urban).
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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