Judul: Efek Penghambatan Tumorigenesis Kelenjar Mammari Yang Diinduksi N-Metil-N-Nitrosourea Oleh Ekstrak Etanol Rimpang Temu Putih (Curcuma zedoaria (Berg.) Roscoe) Secara Makroskopis Pada Kelinci
Abstrak: Penelitian ini bertujuan untuk mengetahui efek penghambatan pembentukan tumor (tumorigenesis) pada kelenjar mammari yang diinduksi dengan n-metil-nnitrosourea (MNU) oleh ekstrak etanol rimpang temu putih (Curcuma zedoaria (Berg.) Roscoe). Sebanyak 9 ekor kelinci betina dengan umur 6-9 bulan digunakan dalam penelitian ini. Kelinci didistribusikan ke dalam 3 kelompok, yaitu kontrol positif tumor, perlakuan dengan curcumin dan perlakuan dengan pemberian ekstrak etanol rimpang temu putih. N-metil-n-nitrosourea digunakan sebagai induksan tumor dengan dosis 50 pgrkg berat badan intra mammari. Ekstrak etanol rimpang temu putih diberikan pada kelinci dengan dosis 250 mgkg berat badan, sedangkan curcumin diberikan dengan dosis 60 mgkg berat badan. Pembentukan tumor diamati secara makroskopis, dengan mengukur diameter tumor kelenjar mammari. Hasil pengamatan memperlihatkan bahwa terjadi penghambatan tumorigenesis pada kelompok yang diberi ekstrak etanol rimpang temu putih. Berdasarkan semua hasil temuan ini disimpulkan bahwa ekstrak etanol temu putih memiliki aktifitas dalam menghambat tumorigenesis.
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Judul: Kajian Mikroskopis Induksi N-Methyl-N-Nitrosourea Pada Kelenjar Mammari Kelinci
Abstrak: The aim of this research is to study the N-Methyl-N-Nitrosourea (MNU) induction on the rabbit’s mammary gland tumour formation. Six 6-9 month old, female rabbit were induced by N-Methyl-N-Nitrosourea (MNU) intramammary dose 50 μg/kg Body Weight, every 1 weeks for 4 week. After 4 weeks of induction, mastectomy were done. The mammary glands were processed for histopathological examination stained with HE. One lactating rabbit was act as normal mammary control. The result showed that the N-Methyl-N-Nitrosourea (MNU) could induced tumorigenesis which characterized as benign and slow growth tumor, as well as the inflammatory reaction.
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Judul: Hamiltonian formulation for linear waves motion in two layers fluid
Abstrak: The surface wave could be considered as a wave that separates two fluids, namely water and air. Based on this assumption, it is introduced the interfacial wave, a wave between two layers of fluid with different density. The formulation of interfacial waves motion begins with deriving the base equation of irrotational ideal fluid. Furthermore, according to irrotational fluid assumption, the base equation can be stated in velocity potential. In this derivation, the fluids domain is assumed to be restricted by rigid lid boundary conditions, both at the upper and lower limit. Therefore, the interfacial waves motion can be explained in a hamiltonian formulation. In the hamiltonian formulation, total energy is defined as the sum of kinetic and potential energy. The hamiltonian system is obtained from reduction of kinetic energy by using the Dirichlet Neumann Operator. The resulted kinetic energy equation is nonlinear. Therefore, this form is linearized by first part of the Taylor expansion. This linearization gives a dispersion relation of linear wave. Based on this dispersion relation, the phase speed of the linear wave depends on the density ratio of the two layers fluid.
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