Judul: IPB (Bogor Agricultural University)
Abstrak: One of the causes reproduction disorder that effect of decreasing reproductive function is cigarette smoke. In Papua, kebar„s grass which in local language called "banondit" (meaning many children) are commonly used by locals as a herbal medicine to overcome reproductive problem. This research aims to create an animal model of decreased reproductive function of male rats with cigarette smoke exposure and to determine the potential of extract kebar‟s grass on reproductive function of male rats exposed to cigarette smoke. The research was conducted in three stages. The first stage was designed to learn the animal model of decreasing reproductive function in male rat exposure with cigarette smoke. The parameters were analysis of microscopic lung, blood profile, analysis of microscopic testes, spermatogenic cells count and spermatozoa quality. The results showed a black particles of cytoplasm alveoli of lung which is predicted as tar in 40d and 60d, increased PCV, decreased testes weight, spermatogenic cells count and spermatozoa quality which did not return to normal conditions after stopping the exposured appropriate time. This confirmed that the animals were exposed to cigarette smoke can be used as an animal model of male reproductive function decline. The second stage was designed to learn the potential of extract kebar‟s grass on blood profile in male rat exposed with cigarettes smoke. The parameters was blood profile is erythrocyte, hemoglobin, hematokrit, indeks eritrosit and Leukosit. The results showed that extract kebar‟s grass 0.0945 mg/gr body weight/day can increased eritrosit in male rat exposed with cigarettes smoke. The third stage was designed to learn the potential of extract kebar‟s grass on testes, testosterone levels, spermatogenic cells count and spermatozoa quality in male rat exposed with cigarettes smoke. The parameters were analysis of testes, analysis of testosterone, spermatogenic cells count and spermatozoa quality. The results showed that extract kebar‟s grass 0.0945 mg/gr body weight/day increased testes weight, amount spermatogenic cells and spermatozoa quality in male rat exposed with cigarettes smoke. From this research could be conclude that giving of extract kebar‟s grass 0.0945 mg/gr body weight/day could increased reproductive function of male rat that exposured by cigarette smoke.
Keyword: Cigarettes smoke, extract kebar‟s grass, spermatogenic, spermatozoa

Judul: IPB (Bogor Agricultural University)
Abstrak: The Indonesia population growth rate during the past 10 years tend to decrease and nearly reach the ideal rate of one percent of growth per year. This success was supported by family planning program and campaign of using contraception. Unfortunately, almost all contraceptive tools and methods affect women. Various effort needs to be done by promoting men contraception, in order to increase participatory rate of men. Medicinal plants have been used as alternative medicine with an asumption that it perform less side effects, beside other consideration such as easy to find and cheaper than the chemical and commercial medicines. One of the medicinal plants that have been used widely in the community is pegagan (Centella asiatica) that used to treat injuries and improve cognitive function. Pegagan has been reported to have an antifertility properties in male rats. However, the scientific reports on the use of this plant on reproduction purposes are still limited. So that, the purpose of this study is to determine the antifertility effect of pegagan extract and reversibility of reproductive capability in male rats. In the first stage, this experiment was done experimentally with a completely randomized design, consisting of 16 combinations of four treatment doses (0, 50, 150 and 450 mg/BW) and four duration of administration (28, 35, 42 and 49 days). Parameters measured were population of spermatogenic cells, sperm quality and testosterone levels. Results of the experiment showed that the population of late spermatids, sperm concentration, sperm motility and testosterone levels decreased following the treatment, although they were still in a normal range. Results of the experiment also indicated that pegagan extract did not affect the population of spermatogonia, primary spermatocytes and sperm abnormality. It also showed that pegagan still be able to maintain testosterone levels within the normal range. Based on these results, it can be concluded that the dose of 450 mg/kg BW caused the lowest level of late spermatids and sperm concentration if compared to the other paramaters. Twenty eight days administration of pegagan appears to be most efficient duration of administration than any longer time. Results of the experiment also indicated that treatment doses of 450 mg/kg BW and duration of 28 days is still able to maintain testosterone levels in the normal range. Decrease of testosterone levels is associated with inhibition of late stages of spermatogenesis. Based on these results, follow up experiment was carried out to explore the antifertility effects of pegagan and its reversibility. The study was conducted with a complete randomized design, with 8 treatment of combination of dose-duration (450 mg/kg BW-21 day, 600 mg/kg BW-21 day, 450 mg/kg BW-28 days, and 600 mg/kg BW-28 days) and the cessation length of pegagan (1 day and 12 days). Several parameters consisting of the degree of spermatogenesis and sperm quality of male rats were determined. Results of the experiment showed that the degree of spermatogenesis and sperm quality decreased after administration of pegagan. The decrease of spermatogenesis may be due to apoptosis process. The results also showed that 12 days cessation length of pegagan cause the increase of developmental stage, quality
Keyword: antifertility, reproductive function, pegagan, rat

Judul: Formulasi Hamiltonian untuk Menggambarkan Gerak Gelombang Soliter Dimensi Tiga di Permukaan Laut
Abstrak: Gelombang permukaan adalah gelombang yang terjadi perbedaan rapat massa antara air dan udara. Salah satu gelombang permukaan yang ditinjau adalah gelombang soliter. Formulasi gelombang soliter dilakukan dengan menggunakan formulasi Hamiltonian.
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