Judul: Durability of Specific Immunoglobulin (Ig) Y Againts Influenza and Covid-19 in Sunscreen
Abstrak: The benefit of specific immunoglobulin Y (Ig Y) as an active ingredient in personal care products such as sunscreen has not been properly studied. Our study aims to evaluate the reliability of specific IgY against influenza and the COVID-19 virus in a sample sunscreen product. Specific IgY influenza and COVID-19 viruses were inserted in the sample sunscreen at two concentrations of 0.1% and 0.25%. Three treatments were observed: control (C) sunscreen without IgY, treatment 1 (T1) sunscreen with 0.1% IgY, and treatment 2 (T2) sunscreen with 0.25% IgY. Organoleptic observations were carried out to monitor changes in aroma, color, and texture, and sunscreen sampling was done every week for 6 weeks. The durability of IgY was evaluated using an enzyme-linked immunosorbent assay (ELISA) and a neutralization assay. Organoleptic observation from weeks 1 to 6 showed consistency in its aroma, color, and texture. Enzyme-linked immunosorbent assay and neutralization assay (NA) results of the T1 and T2 groups showed negative results except for sample T1 at week 5, which showed a positive result in the Influenza A ELISA. Based on the results, it seems that IgY concentrations of 0.1% or 0.25% were not optimal. However, this negative result might be due to low concentration of the IgY and the presence of beeswax, which inhibits IgY and causes it to dissolve in distilled water, thus preventing it from being detected in the assay.
Keyword: Immunoglobulin Y, Sunscreen, Influenza, COVID-19, Biological Activity

Judul: Daya Tahan IgY Spesifik Terhadap Influenza dan COVID-19 dalam Balsam Bibir
Abstrak: Influenza and SARS-CoV-2 virus are respiratory infections and require antiviral medications due to severe consequences. Utilization of specific immunoglobulin Y (IgY) inserted in personal care products were developed. The aim of this study was to evaluate durability of specific IgY against influenza and COVID-19 in lipbalm. The concentration of IgY used in this research was 0.1% and 0.25%. Three groups were observed: control (C) lipbalm without IgY, treatment 1 (T1) lipbalm with 0.1% IgY and treatment 2 (T2) lipbalm with 0.25% IgY. Organoleptic tests were conducted and recorded which includes the sense of smell, colour and consistency for six weeks. The presence of IgY in lipbalm was evaluated using enzyme-linked-immunosorbent-assay (ELISA) and neutralizationassay. There were some noticeable changes of organoleptic that can be observed such as colour darkened and texture hardened of the lipbalm. Most of the assays gave negative results in T1 and T2, whilst only few of them were doubtful. Our result indicated that IgY concentration of 0.1% or 0.25% in lipbalm were not optimal. However, the negative result might be due to the unavailability of IgY in the product to be dissolved in deionized water since we used beeswax as lipbalm component.
Keyword: Covid-19, egg yolk immunoglobulin Y, lipbalm, influenza

Judul: Penyelesaian Stacker Crane Problem dengan Algoritme Largearcs dan Smallarcs
Abstrak: In graph theory, the Rural Postman Problem (RPP) aims to determine the shortest route with minimum cost, in which only certain edges or arcs are necessarily traversed. One type of RPP is Stacker Crane Problem (SCP) which deals with a mixed graph but only arcs are necessarily traversed. SCP can be solved by using two heuristic algorithms, i.e. Largearcs and Smallarcs algorithms, which include other algorithms in their steps, such as: Dijkstra algorithm to determine shortest route, Hungaria method to determine minimum bipartite matching, Prim algorithm to determine minimum spanning tree, and van Aardenne-Ehrenfest & de-Bruijn algorithm and Fleury algorithm to determine Euler circuits. The shortest Euler circuit resulted from two heuristic algorithms can be used to find a solution of SCP. The application of SCP is illustrated in establishing the minimum distance route of catering delivery.
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