Judul: Aktivitas Antidiabetes Ekstrak Kulit Buah Salak Manonjaya dengan Ikan Zebra (Danio rerio) sebagai Hewan Model.
Abstrak: Penelitian bertujuan menentukan fraksi aktif dan profil senyawa aktif pada ekstrak kulit buah salak manonjaya yang berperan sebagai antidiabetes serta menentukan aktivitas antidiabetes menggunakan hewan uji berupa ikan zebra. Kulit buah diekstraksi dengan cara maserasi menggunakan pelarut etanol 70% kemudian difraksionasi menggunakan n-heksana, etil asetat dan metanol. Fraksi aktif adalah fraksi etil asetat dengan rendemen tertinggi 0.94%, kadar fenolik total tertinggi 1087 mg ekivalen asam galat/g ekstrak, kadar flavonoid total tertinggi 150 mg ekuivalen kuersetin/g ekstrak, penghambatan α-glukosidase paling kuat berdasarkan persen inhibisi 64.43% dan yang memberikan spot teraktif sebagai inhibitor α-glukosidase. Profil senyawa aktif yang berperan sebagai senyawa antidiabetes ialah flavonoid dari golongan glikosilflavon dan flavon. Aktivitas antidiabetes menggunakan ikan zebra, menunjukkan bahwa ekstrak kulit buah salak manonjaya dari ekstrak kasar etanol dan fraksi etil asetat dapat menurunkan kadar gula darah ikan zebra yang diinduksi dengan aloksan.
Keyword: fraksionasi, ikan zebra, inhibitor α-glukosidase, KLT bioautografi

Judul: Pendekatan Bioinformatika Formulasi Jamu Baru Berkhasiat Antidiabetes dengan Ikan Zebra (Danio rerio) sebagai Hewan Model
Abstrak: Jamu composition was formulated without any provision like Traditional Chinese Medicine. Recent studies showed regularity pattern through statistical database. Jamu formulations in this study were made using Design Expert and its efficacy predicted using models partial least square discriminant analysis (PLSDA), coefficient PLSDA multiways, and Support Vector Machine. The prediction indicated that 4 plants used were sembung, pare, ginger, and bratawali. The efficacy was verified using zebrafish (D. rerio) as an animal test. Hyperglycemia in the fish was induced by soaking them in alloxan 0.1% for 10 min, glucose 1% for 10 min, and distilled water for 60 min in sequence. One-way t test showed that the increasing blood sugar levels was not significant (p>0.05). These results confirm that the induction process have not been successful to increase the average blood sugar levels. Application of jamu into the fish was done for 3 days after the induction. Statistical observation for all compositions of jamu showed that group 1 has the greatest decline difference.
Keyword: zebrafish, jamu, bioinformatic of jamu, antidiabetic

Judul: Implementation of Spatio-Temporal Change Query in Relational Database.
Abstrak: Geographic object changes in various views. Object changes are recorded using a model of static storage. No historical connection between old version data and new version data has been built. For that, a storage model of spatio-temporal queries that can analyze spatio-temporal changes has been developed. The object changes the geometry are grouped according to the taxonomy of Spatio-Temporal Pattern Change. This research has been able to apply the query patterns change including born, expand, merge, contract, split, normal and die. This query based on geometric (area) changes. The implementation of spatio-temporal change queries represents an object changes continuously with easy, change detection is done by comparing two versions of data. Keyword: spatio-temporal change query, spatio-temporal change pattern.
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