Judul: Mapping Shoreline Changes Using Landsat Imagery at Pemalang, Central  Java
Abstrak: Kabupaten Pemalang memiliki kondisi geografis landai dengan perairan dangkal sehingga potensial dilakukan peningkatan wilayah untuk perikanan tambak maupun pariwisata. Pemanfaatan tersebut menyebabkan perubahan garis pantai yang dapat terjadi oleh faktor manusia dan alam. Penelitian ini bertujuan memetakan perubahan garis pantai di Pemalang, Jawa Tengah dari 2007-2022 menggunakan landsat 7 ETM+ dan Landsat 8 OLI/TIRS. Metode digital shoreline analysis system (DSAS) dilakukan untuk menghitung statistik laju perubahan untuk rangkaian waktu data vektor garis pantai. Metode ini menggunakan parameter, meliputi baseline, shoreline, dan transek. DSAS menghasilkan perubahan garis pantai (NSM) dari tahun 2007-2022 dan perubahan garis pantai rata-rata (EPR) selama 15 tahun. Seluruh subzona pengamatan mengalami abrasi. Subzona D2 mengalami abrasi terbesar (-442.43 m). Wilayah yang mengalami akresi mencakup subzona A1, A3, B1, B3, C2, C3, D1, D2, E2, dan E3. Akresi terbesar terjadi di subzona A3 (333.05 m). Pantai Pemalang pada 2007-2022 mengalami perubahan garis pantai yang didominasi abrasi. Abrasi terbesar pada subzona A3 (-2.39 m/tahun) dan terkecil pada A2 (-1.89 m/tahun). Faktor abrasi di pantai Pemalang ialah pantai yang landai, penggunaan lahan sebagai daerah wisata, kondisi mangrove tidak terawat, serta fenomena banjir pada Mei 2022. Perubahan garis pantai yang terjadi bersifat berat hingga sangat berat.
Keyword: abration, DSAS, shoreline, landsat

Judul: Detection of Coastline Changes Using Landsat Imagery in the Coastal of Sumur, Pandeglang, Banten.
Abstrak: Pesisir merupakan kawasan peralihan antara darat dan laut sehingga sangat potensial sebagai lokasi pembangunan dan cenderung mendapat tekanan yang berat sehingga rawan terhadap perubahan. Penginderaan jauh efisien dan efektif dalam pemantauan perubahan garis pantai. Penelitian ini dilakukan di pesisir Sumur, Pandeglang, Banten. Metode Digital Shoreline Analysis System (DSAS) digunakan untuk menghitung statistik laju perubahan garis pantai. Program DSAS membutuhkan beberapa parameter dalam pengukuran laju perubahan garis pantai seperti baseline, shoreline yang sudah terkoreksi pasang surut, dan transek. Perubahan garis pantai dihitung pada transek dengan perhitungan Net Shoreline Movement (NSM) dan End Point Rate (EPR). Abrasi terjadi pada subzona A2, A3, B3, C3, D1, D2, dan D3.Wilayah yang mengalami akresi meliputi subzona A1, A2, A3, B1, B2, dan B3. Perubahan garis pantai berupa abrasi terbesar terjadi di sub zona D1 dengan nilai -77 m. Nilai perubahan berupa akresi terbesar terjadi pada sub zona A3 yaitu sebesar 61,11 m. Perubahan yang terjadi disebabkan adanya arus menyusur pantai yang dipengaruhi oleh angin. Perubahan garis pantai yang terjadi bersifat ringan hingga sedang., Coastal area is a transitional area between land and sea which is very potential to be developed and tends to be under heavy pressure, thus it is vulnerable to change. Remote sensing is an efficient and effective tools in monitoring shoreline changes. This research was conducted on the coast of Sumur, Pandeglang, Banten. The Digital Shoreline Analysis System (DSAS) method was used to calculate the rate of change of the time series of shoreline vector data. The DSAS program requires several parameters in measuring the rate of shoreline change in this study, such as the baseline, tide-corrected shoreline, and transects. Shoreline changes were calculated on the transect by calculating the Net Shoreline Movement (NSM) and End Point Rate (EPR). Abrasion was occurred in subzones A2, A3, B3, C3, D1, D2, and D3. Accretion was occurred in subzones A1, A2, A3, B1, B2, and B3. Larges abrasion in shoreline was occurred in sub zone D1 with a value of -77 m. The larges accretion occurred in the A3 sub zone, which was 61.11 m. The changes are caused by the current along the coast which is influenced by the wind. Changes in the coastline that occur are mild to moderate.
Keyword: Abrasi, Akresi, DSAS, Garis Pantai, Landsat

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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