Judul: Persepsi Pra Pasangan Usia Subur Terhadap Niat Mengamalkan Norma Keluarga Kecil Bahagia Sejahtera (NKKBS)
Abstrak: Masalah yang dikaji dalam penelitian ini adalah sejauh mana tingkat persepsi Pra Pasangan Usia Subur di kabupaten Labuhan Batu dan Kabupaten Tapanuli Utara sebagai lokasi penelitian terhadap program Keluarga Berencana, Dayadukung sumberdaya Alam dan Lingkungan Hidup serta niat mengamalkan Norma Keluarga Kecil Bahagia Sejahtera. Apakah faktor suku, jenis kelamin,umur, tingkat pendidikan, ekonomi keluarga, pekerjaan, jumlah anak bersaudara serta media informasi merupakan penghambat atau pendorong dalam pemahaman tersebut.
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Judul: Persepsi Pasangan Usia Subur (PUS) Tentang Keluarga Kecil, Kasus Pada Etnis Batak Toba di Daerah Asal dan Perantauan
Abstrak: Penelitian ini bertujuan untuk : (1) mengetahui persepsi PUS tentang Keluarga Kecil di: daerah asal maupun di daerah perantauan, (2) mengetahui faktor kharakteristik personal (umur, tingkat pendidikan formal, tingkat ekonomi keluarga, lama berkeluarga, dan kekosmopolitan), dan faktor kharakteristik situasional (keterikatan terhadap adat istiadat, dan interaksi dengan kelompok informal etnis Batak Toba) yang berhubungan dengan persepsi tentang Keluarga Kecil di daerah asal maupun di daerah perantauan. Pengumpulan data dilaksanakan di Kecamatan Lumban Julu (daerah asal) dan Kecamatan Medan Baru Kotamadya Medan (daerah perantauan) di Propinsi Sumatera Utara sejak bulan Juni hingga Juli 1998. Penentuan sampel area dan sampel individu dilakukan dengan metode disproporsionate stratrfied random sampling, yakni 3 desa di daerah asal dengan jumlah sampel sebanyak 40 orang, dan 2 kelurahan di daerah perantauan dengan jumlah sampel yang sama. Kriteria sampel individu adalah Pasangan Usia Subur yakni pasangan yang istrinya berusia 15-49 tahun, etnis Batak Toba, dan telah berdomisili minimal 5 tahun di daerah penelitian. Analisis data dilakukan dengan menggunakan uji komparatif Man Whitney U Test dan uji korelasi peringkat Spearman.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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