Judul: IPB (Bogor Agricultural University)
Abstrak: Hypercholesterolemia and LDL oxidation are the major factors of atherosclerosis. The ethanol extract of the ginger (EEG) and Zn each posses effect reduce cholesterol and antioxidant. These research combined EEG and Zn as antihypercholesterolemia and antioxidant to prevent atheroma in New Zealand white fed rabbits atherogenic diet and hypercholesterolemia rabbits. Twenty eight male rabbits were divided into seven groups. For 6 weeks, group 1 was fed with a normal diet and group 3 was fed with an atherogenic diet. Beside the atherogenic diet, group 2,4,5,6, and 7 were also treated by supplementary treatment. Second phase research, 24 male hypercholesterolemia rabbits were divided into 6 groups. For 6 weeks, group 1 was fed with a normal diet. Fed rabbits atherogenic diet group 2,4,5,6, and 7 and hypercholesterolemia rabbits group 2,3,4,5, and 6 were treated by supplementary treatment, which are Zn 6.67 mg/kg, EEG 200 mg/kg, combination EEG 50 mg/kg and Zn 6.67 mg/kg, combination EEG 100 mg/kg and Zn 6.67 mg/kg, and atorvastatin (positive control) 1.9 mg/kb BW per day. Combination EEG 50 mg/kg and Zn 6.67 mg/kg and combination EEG 100 mg/kg and Zn 6.67 mg/kg treatment impeded the increase of total cholesterol, LDL, and prevent atheroma equal to the positive control. Based on the ability to restrain the increase of MDA (lipid peroxidation) in fed rabbits atherogenic diet the treatment with combination EEG 50 mg/kg and Zn 6.67 mg/kg resulted higher than positive control or the other treatment. Based on reduced plaque atheroma in hypercholesterolemia rabbits, combination EEG 50 mg/kg and Zn 6.67 mg/ kg treatment also the best result. These researches concluded that combination EEG 50 mg/kg and Zn 6.67 mg/kg BW per day treatment exhibited the highest atheroma prevention effect in fed rabbits atherogenic diet or hypercholesterolemia rabbits as compared to the positive control or the other treatments.
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Judul: Proses Peroksidasi Lipid Kelinci yang Hiperlipidemia pada Pemberian Senyawa Penurun Kolesterol
Abstrak: Free radicals, such as lipid peroxide, are having much attention right now because their significant role in degenerative disease. Hyperlipidemia is one of the major risk factor for atherosclerosis and lead to degenerative disease. The aim of this study was to determine the effect of cholesterol lowering substance to the blood peroxide lipid concentration in hyperlipidemic rabbit. Twenty four male New Zealand white rabbits were divided into four groups: normal (given standard rabbit feed), hyperlipidemia (given atherogenic rabbit feed contained 0.5% cholesterol and 5% coconut oil), lovastatin (given mixture of atherogenic rabbit feed and lovastatin 57 mg/day), and extract (given atherogenic rabbit feed and jati belanda leaves extract mixture). Thiobarbitnric acid (TBA) method was used in blood lipid peroxide analysis, measuring the MDA product by spectrophotometer at 532 nm. The result showed that the atherogenic rabbit feed caused the elevation of MDA concentration, which means the elevation of lipid peroxidation process. Blood lipid peroxide concentration in hyperlipidemia group increased 163.76% compared with normal group (1.30 ± 0.38 nmol/ml). Lovastatin and jati belanda leaves extract mixture can act as antioxidant which can lowering blood lipid peroxide concentration 46.92% and 53.03% respectively at 8th week compared with hyperlipidemia group.
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Judul: Karakter Lanskap Lokal pada Pantun Adat Minangkabau
Abstrak: Minangkabau adalah salah satu kebudayaan tertua dan terbesar di Indonesia. Minangkabau dikenal oleh keunikan dan ciri khasnya sendiri dari abad ke abad. Keunikan dan ciri khas itu tidak hanya melekat pada budaya, tapi juga melekat pada aspek lainnya seperti warisan budaya, peninggalan sejarah, budaya tradisional, hingga karakter lanskapnya. Salah satu warisan budaya terkenal Minangkabau adalah Pantun. Pantun adalah warisan budaya Minangkabau yang paling dekat kaitannya dengan kehidupan sehari-hari masyarakat Minangkabau. Pantun biasanya digunakan sebagai pelengkap atau tambahan pada percakapan harian, sebagai pembuka atau sambutan pada acara adat, atau sebagai pepatah dan peribahasa yang digunakan sehari-hari. Penelitian ini bertujuan untuk mengidentifikasi dan menganalisis bacaan pantun adat Minangkabau yang menunjukkan karakter lanskap lokal Minangkabau. Penelitian ini menggunakan metode deskriptif dengan melakukan analisis dan studi literatur melalui wawancara dan observasi lapang. Keberagaman elemen lanskap baik dari segi elemen fitur alami maupun elemen fitur buatan yang terkandung di dalam pantun adat Minangkabau mencerminkan kekayaan karakter lanskap Minangkabau itu sendiri. Fitur alami dan buatan yang ada dalam pantun mempunyai bobot yang relatif sama atau seimbang. Fitur alami yang paling dominan dalam pantun adalah landform, khususnya elemen gunung. Fitur buatan yang paling dominan adalah elemen pemukiman, khususnya elemen pasar. Karakter kunci lanskap Minangkabau adalah gunung Marapi, gunung Singgalang, danau Singkarak, danau Maninjau, dan bukit Barisan. Karakter lanskap Minangkabau memperlihatkan lanskap pemukiman yang berada di tengah elemen-elemen pembentuk lanskap yang luas seperti gunung, lautan, sawah atau ladang, dan sungai. Keberadaan elemen lanskap yang terdapat pada pantun Adat Minangkabau baik pantun lama maupun pantun baru masih terjaga kelestariannya. Keberadaan fitur lanskap pada pantun adat Minangkabau merupakan adaptasi lingkungan sekitar oleh sastrawan Minangkabau yang dituangkan kedalam karya seni berbentuk literatur.
Keyword: lanskap budaya, lanskap tradisional, taman vernakular, rumah gadang, lanskap minangkabau, pantun adat