Judul: Sitotoksisitas dan Toksisitas Daun Miana (Coleus scutellarioides [L] Benth)
Abstrak: Daun miana (Coleus scutellarioides [L] Benth) telah digunakan masyarakat secara tradisional dalam mengobati beberapa penyakit. Penelitian ini bertujuan menentukan nilai LC50, toksisitas akut, mengetahui gejala toksik, dan wujud toksik dengan pengamatan histopatologi pada organ hati. Uji sitotoksisitas menggunakan larva udang (metode BSLT) dan uji toksisitas akut menggunakan mencit betina (metode OECD dan kriteria GHS). Berdasarkan hasil penelitian, nilai LC50 ekstrak aseton daun miana adalah 787.93 µg/mL. Toksisitas akut ekstrak aseton daun miana termasuk kategori 4 (>2000-5000 mg/kgBB) atau dalam kategori toksisitas rendah. Ekstrak aseton daun miana tidak menimbulkan kematian maupun gejala toksik yang tidak dapat ditoleransi hingga hari ke-14 setelah pemajanan. Pengamatan histopatologi menunjukkan terbentuknya lesi di beberapa sampel organ hati berupa degenerasi sentrolobular dan nekrosis.
Keyword: Coleus scutellarioides, Histopathology, LC50, Acute Toxicity, OECD 423, Histopatologi, Aktivitas sitotoksisitas, Potensi toksisitas akut, Gejala toksik

Judul: Aktivitas Antifungi Ekstrak Daun Miana (Coleus scutellariodes [L] benth) pada Pertumbuhan Candida albicans Secara In Vitro
Abstrak: Miana (Coleus scuttellariodes [L] Benth) is one of the traditional medicine from family Lamiceae having flavonoids, tannins, saponins, steroids, and triterpenoids compound those can be used as antifungal. The objectives of this research were to examine the antifungal activity of Coleus scuttellariodes [L] Benth leaves extract against C. albicans and to analyze the active compounds in Coleus scuttellariodes [L] Benth leaves extract that has potential as an antifungal against C. albicans. The methods of this research were extraction with aquades, etanol 70%, and acetone, antifungal activity test by agar well diffusion and identification of active compound extract with the best inhibition in antifungal activity with Gas Chromatography-Mass Spectrometry (GC-MS). The result showed that acetone extract 400 mg/mL had the highest inhibition activity with the zone of 4.66 mm included in the low category, meanwhile aquades and etanol 70% extract did not show antifungal activity. Positive control nystatin concentration of 1.028 mg/mL is more effective in inhibiting of C. albicans. Minimum inhibition concentration value of acetone extract was 1.56 mg/mL. Identification of acetone extract with GC-MS result phytol in amount of 41.29%.
Keyword: Coleus scutellariodes, Candida albicans, antifungal

Judul: Implementation of Spatio-Temporal Change Query in Relational Database.
Abstrak: Geographic object changes in various views. Object changes are recorded using a model of static storage. No historical connection between old version data and new version data has been built. For that, a storage model of spatio-temporal queries that can analyze spatio-temporal changes has been developed. The object changes the geometry are grouped according to the taxonomy of Spatio-Temporal Pattern Change. This research has been able to apply the query patterns change including born, expand, merge, contract, split, normal and die. This query based on geometric (area) changes. The implementation of spatio-temporal change queries represents an object changes continuously with easy, change detection is done by comparing two versions of data. Keyword: spatio-temporal change query, spatio-temporal change pattern.
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