Judul: Optimasi Kombinasi Simplisia Keladi Tikus, Temu Ireng, dan Temulawak sebagai Kandidat Sediaan Jamu Antikanker Payudara.
Abstrak: Kanker merupakan salah satu penyakit yang membahayakan dan menjadi masalah kesehatan terbesar bagi masyarakat dunia. Keladi tikus, temu ireng, dan temulawak merupakan tanaman tradisional yang berpotensi sebagai antikanker. Penelitian ini bertujuan melakukan optimasi kombinasi simplisia keladi tikus, temu ireng, dan temulawak dalam berbagai respon. Metode penelitian ini terdiri dari preparasi dan ekstraksi, pengukuran total fenol, pengukuran total flavonoid, uji antioksidan, Brine Shrimp Lethality Test (BSLT), dan uji antiproliferasi terhadap sel MCF-7 dan sel Vero. Analisis seluruh hasil penelitian dilakukan berdasarkan model Simplex Centroid Design dengan Design Expert. Nilai optimum titik optimasi diperoleh pada kombinasi simpilisa keladi tikus dan temulawak dengan perbandingan 0.303:0.697. Hasil tertinggi yang akan diperoleh berdasarkan titik optimasi, yakni total fenolik sebesar 66.14 mg GAE/g, flavonoid 32.27 mg QUE/g, antioksidan DPPH 98.12%, antiproliferasi sel MCF-7 sebesar 52.17%, dan antiproliferasi sel Vero sebesar 6.86%.
Keyword: Antioksidan, antiproliferasi, sel MCF-7, sel Vero, fenolik, flavonoid

Judul: Molecular Docking of Compounds of Ethanol Extract of Temu Ireng Rhizome (Curcuma aeruginosa Roxb.) as Antioxidant and Anticancer.
Abstrak: Kanker merupakan salah satu jenis penyakit berbahaya yang mengalami peningkatan kasus setiap tahunnya. Radikal bebas merupakan penyebab mutasi gen yang dapat memicu kanker. Kanker akan berkembang tanpa terkendali karena terjadinya disregulasi siklus sel dan adanya senyawa pemicu proliferasi sel serta penghambat proses apoptosis. Pengobatan kanker dilakukan dengan memberikan inhibitor cyclin dependent kinase2 (CDK2) dan cyclooxygenase-2 (COX-2) untuk menghambat perkembangan kanker, serta inhibitor lipoxygenase (LOX) untuk menghambat pembentukan radikal bebas. Tanaman temu ireng diketahui memiliki potensi sebagai antioksidan dan antikanker. Penelitian ini bertujuan mengetahui interaksi molekuler antara senyawa dominan ekstrak etanol temu ireng dengan CDK2, COX-2, dan LOX sebagai reseptor. Jenis interaksi ligan dengan reseptor ditentukan melalui parameter energi afinitas (ΔG), konstanta inhibisi (Ki), jenis interaksi dan persentase binding site similarity (%BSS). Hasil penelitian menunjukkan bahwa senyawa uji gajutsulacton A memiliki potensi terbaik dalam menghambat CDK2. Senyawa uji cucumenol berpotensi sebagai inhibitor COX-2 tetapi tidak terdapat senyawa yang dapat menghambat LOX dengan baik sebagai antioksidan., Cancer is one type of dangerous disease that is increasing every year. Free radicals are the cause of gene mutations which can lead to cancer. Cancer will develop uncontrollably due to the dysregulation of the cell cycle and the presence of compounds which trigger cell proliferation and inhibit the process of apoptosis. Cancer treatment is carried out by giving cyclin-dependent kinase2 (CDK2) and cyclooxygenase-2 (COX-2) inhibitor drugs to inhibit cancer development, as well as lipoxygenase (LOX) inhibitor drugs for the formation of free radicals. The temu ireng plant is known to have the potential as an antioxidant and anticancer. This study aims to determine the molecular interaction between the dominant compound of temu ireng ethanol extract with CDK2, COX-2, and LOX receptors. The type of ligand interaction with the receptor was determined through the parameters of affinity energy (ΔG), inhibition constant (Ki), type of interaction, and percentage of binding site similarity (%BSS). The results showed that the test compound gajutsulacton A had the best potential in inhibiting CDK2. The test compound cucumenol may be a COX-2 inhibitor and there are no compounds that can inhibit LOX well as an antioxidant.
Keyword: Anticancer, Antioxidant, CDK2, COX-2, LOX

Judul: Sectoral Effects Of Monetary Policy
Abstrak: The purposes of this study are three folds: (1) identifying which channels are effective for transmission of monetary policy; (2) assessing whether the transmission mechanisms at industry level are consistent with that at aggregate level; and (3) explaining why and how a channel becomes effective. The analyses are facilitated impulse response function (IRF) derived from a vector autoregression (VAR) model. Three channels are identified in this study: interest rate, real credits and exchange rate channels. The IRF results show that exchange rate is the only effective channel in affecting aggregate output and at least in five industries (the manufacturing industry; the construction industry; the trade, hotel, and restaurants industry; the transport and communication industry; and the finance, real estate, and business services industry). Meanwhile, the other two channels are not effective at aggregate and all industry. This finding suggests that there is some form of consistency between aggregate effects and industry effects. Moreover, the effect of real depreciation tend to be contractionary and thus supporting the idea of Krugman and Taylor (1976) among others. Output contraction seems to be associated with inflationary effect of the depreciation. This is a truly Keynesian type demand side story: following a real currency depreciation, purchasing power tends to weaken which then soaks the aggregate demand.
Keyword: transmission of monetary policy, industry level, IRF