Judul: Antidiare enkapsulasi Lactobacillus plantarum Mar8 pada tikus putih yang diinduksi minyak jarak
Abstrak: Lactobacillus plantarum Mar8 is lactic acid bacteria has Mannose Specific Adhesion (MSA) that able to attach and form colonies in the intestine, so that could be expected to function as an antidiarrheal. Effects of bacteria L. plantarum Mar8 encapsulated against castor oil-induced diarrhea in Sprague-Dawley rats were observed for six hours. Animals were divided into six groups, each 5 rats: normal group (NaCl 0,85% pH 7), positive controls (castor oil 1,5 mL/rat + loperamid 5 mg/kgBW), negative controls (castor oil 1,5 mL/rat), PI group was induced with castor oil and then after one hour was given L. plantarum Mar8 encapsulated, PII was induced castor oil and in the same time was given L. plantarum Mar8, PIII was induced L. plantarum Mar8 and then after one hour was induced with castor oil. Frequency of diarrhea, faeces weight, and consistency of faeces observed for six hours. Three rats from each groups were taken to gastrointestinal motility test, and followed by the observation of histopathological of the stomach and small intestine. The remaining two rats for immune system activity test. The results showed that the frequency of diarrhea has decreased, the PI (80%), PIII (42,86%). Faeces weight was also decreased to PI (84,29%), and PIII (57,35%). While the frequency of diarrhea and faeces weight of PII showed increased. Gastrointestinal motility could reduced by the PI. Measurements percentage of immune system activity showed that PI (45%), PII (48,5%), PIII (45%) and positive control (42%). Observation of histopathological showed all groups got necrosis in villous mucosa and tunica muscularis, and infiltration of mononuclear cells and neutrophils, fibrinoid fluid and goblet cells. Thus, L. plantarum Mar8 encapsulated could treatment of diarrhea but could not effect of stomach and small intestine histophatology.
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Judul: Deteksi Secara Imunohistokimia Imunoglobulin A (IgA) pada Usus Halus Tikus yang Diberi Bakteri Asam Laktat (BAL) dan Enteropatogenik Escherichia coli (EPEC)
Abstrak: This study was conducted to evaluate the effect of Lactobacillus plantarum and Lactobacillus fermentum on the immunohistochemical profile of immunoglobulin A (IgA) and the intestinal mucosa thickness of Enteropathogenic E. coli (EPEC) treated rats. A total of 90 male Sparague Dawley rats were used in this study. They were divided into 6 groups: (1) negative control treated group, (2) Lactobacillus plantarum treated group, (3) Lactobacillus fermentum treated group, (4) Lactobacillus plantarum and EPEC treated group, (5) Lactobacillus fermentum and EPEC treated group, and (6) EPEC treated (positive control) group. The results showed that both Lactobacillus fermentum and Lactobacillus plantarum treatment for 2 to 3 weeks increased the thickness of rat’s mucosal small intestine. In the EPEC treated rats, either Lactobacillus fermentum and Lactobacillus plantarum treatment for 2 weeks increased the thickness of rat’s mucosal small intestine. Lactobacillus fermentum treatment for 2 weeks increased the content of IgA in rat’s mucosal small intestine at both conditions; with and without EPEC treatment. Lactobacillus plantarum treatment for 2 weeks only increased the content of IgA in rat’s duodenum and jejunum, while in the EPEC treated rats, Lactobacillus plantarum treatment for 2 weeks could maintained the content of IgA in rat’s mucosal small intestine. Lactobacillus fermentum gave better effect than Lactobacillus plantarum on increasing the content of IgA in rat’s small intestine
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Judul: Heisenberg Uncertainty of Double SlitSystem Based on Budiyono-Rohrlich Quantum Statistics Model
Abstrak: Interpretasi kuantum dikembangkan untuk memaknai secara fisis dengan jelas bagaimana suatu dinamika pada sistem mikroskopis yang dijelaskan dengan teori-teori kuantum, seperti interpretasi Copenhagen yang mendeskripsikan sistem kuantum sebagai suatu keadaan yang dideskripsikan dengan fungsi gelombang yang berisikan bagaimana peluang keadaan suatu sistem. Interpretasi kuantum juga bisa dibawa dari suatu sistem klasik seperti pada model statistika-kuantum Budiyono-Rohrlich yang menjelaskan bagaimana dinamika kuantum berhubungan dengan sistem klasik dengan penerapan statistika pada model Hamiltonian sistem. Fungsi distribusi dapat mendeskripsikan bagaimana suatu sistem terdistribusi pada suatu ruang pada pandangan klasik namun untuk sistem kuantum fungsi distribusi adalah peluang dari sistem tersebut. Sistem klasik dan kuantum juga dipisahkan berdasarkan pada ketidakpastian Heisenberg tentang suatu pengukuran yang tidak bisa secara sekaligus dilakukan bersamaan. Model statistika-kuantum Budiyono-Rohrlich membawa suatu sistem klasik menjadi sistem kuantum dengan dua aksioma yaitu hukum kekekalan energi rata rata dan konservasi rapat probabilitas. Sistem klasik yang didefinisikan akan diatur dengan menambahkan dua variable matematis berupa ontic extensions dan epistemic restrictions dimana kedua variabel ini yang akan menghubungkan bagaimana sistem klasik bisa diubah menjadi sebuah sistem kuantum. Dua variabel matematis tadi membuat sebuah sistem bisa diperlihatkan ketidakpastiannya lewat perhitungan simpangan rata-rata dan hasilnya akan selalu memenuhi ketidakpastian Heisenberg
Keyword: fungsi distribusi, model Budiyono-Rohrlich, ontic extension, epistemic restriction, ketidakpastian Heisenberg