Judul: Perbandingan metode pemulusan brown dan holt pada peramalan gempa bumi se-Jawa Barat-Banten
Abstrak: Metode pemulusan eksponensial merupakan salah satu, metode peramalan yang menggunakan pembobotan data masa lalu secara eksponensial. Metode pemulusan eksponensial ganda satu parameter dari brown dan metode pemulusan ganda dua parameter dari holt digunakan untuk mengprediksi banyaknya gempa bumi se-Jawa Barat-Banten di masa yang akan datang.
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Judul: Analisis Curah Hujan Bulanan Menggunakan Metode Exponential Smoothing (Studi Kasus: Katulampa Bogor).
Abstrak: Curah hujan merupakan salah satu unsur iklim yang penting di Indonesia karena keragamannnya sangat tinggi baik menurut waktu maupun tempat. Katulampa Bogor termasuk daerah di Jawa Barat dengan curah hujan yang tinggi dan bervariasi, dan memiliki pola sebaran curah hujan monsoonal, sehingga penelitian ini dilakukan untuk peramalan curah hujan pada daerah Katulampa bogor. Telah banyak metode peramalan yang digunakan, salah satunya metode Exponential Smoothing. Perlu adanya perbandingan hasil ramalan pada tiap metode Exponential Smoothing yang digunakan. Metode Exponential Smoothing yang dibandingkan yaitu metode Single Exponential Smoothing (SES), metode SES pendekatan adaptif, metode Linear Exponential Smoothing (LES) oleh Brown, dan metode LES oleh Holt. Metode baik yang dihasilkan untuk meramalkan curah hujan bulan Januari sampai Desember berbeda-beda. Hasil metode LES oleh Brown dan LES oleh Holt menunjukkan adanya tren pada curah hujan bulan Maret, Mei, dan Nopember di Katulampa Bogor. Hasil metode SES dan SES adaptif menunjukkan tidak adanya tren pada curah hujan bulan Januari, Februari, April, Juni, Juli, Agustus, September, Oktober, dan Desember di Katulampa Bogor. Metode Exponential Smoothing yang digunakan lebih efektif dan bagus untuk menganalisi tren jika dibandingkan untuk meramalkan curah hujan Katulampa Bogor.
Keyword: Analisis Tren, Curah Hujan, Pemulusan Eksponensial, Peramalan, Perbandingan Metode

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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