Judul: Histopatologi hati, ginjal dan paru mencit bunting akibat pemberian ekstrak daun katuk
Abstrak: Penelitian ini bertujuan untuk mengetahui pengaruh daun katuk terhadap perubahan histopatologi organ hati, ginjal dan paru-paru mencit (Mus musculus). Penelitian ini menggunakan 36 ekor mencit, dibagi ke dalam 3 kelompok perlakuan yaitu kontrol (K), ekstrak daun katuk kering (KK) dan ekstrak daun katuk hijau (KH) yang masing-masing kelompok terdiri dari 12 ekor mencit. Kelompok KK dan KH diberi dalam bentuk ekstraknya dengan dosis 1,68 g/kgBB melalui minum (0,6%). Pengambilan sampel organ hati, ginjal dan paru-paru dilakuakn pada hari ke-0, 2, 5 dan 7 post partus untuk pengujian histopatologi. Hasil penelitian menunjukkan bahwa daun katuk tidak menyebabkan perubahan histopatologi pada paru-paru karena perubahan yang terjadi pada kelompok kontrol. Perubahan terjadi pada organ hati dan ginjal ditandai dengan munculnya degenerasi lemak yang bersifat sementara karena tidak berlanjut sampai nekrosa dan tergolong dalam tingkat ringan. Degenerasi lemak diduga merupakan efek samping akibat mengkonsumsi daun katuk, namun mekanismenya sampai saaat ini belum diketahui dengan pasti.
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Judul: Gambaran Histopatologi Hati dan Ginjal Tikus Laktasi yang Diberi Ekstrak dan Fraksi Sauropus androgynus (L.) Merr Sejak Bunting Sampai 10 Hari Postpartus
Abstrak: This study was aimed to obtain the information about the possibility of side effects (toxic) from consuming of katuk (Sauropus androgynus) leaf extract and fractions using rats as experimental animals. Fifteen pregnant female rats were divided into 5 treatment groups; control (K), ethanol crude exstract (EEtOH), hexan fraction (F-H), ethylacetate fraction (F-EtAc), and water fraction (- FH2O). The katuk leaf extract and fraction were fed from the beginning of pregnancy until 10 days postpartus. Histopathological assay was conducted to investigate the effect of treatment to the liver and kidneys at 10 days postpartus. Histopathology of liver showed that the katuk leaves extract group F-H2O, F-EtAc, and E-EtOH are able to protect the hepatocyts of the liver from apoptosis, but the katuk leaves extract or their metabolites tended to increase the number of apoptosis on renal tubular epithelium of the kidneys. For both organs, the result indicated that the group of katuk leaves water fraction (F-H2O) treatment cause the minimal damage among the others.
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Judul: Hamiltonian formulation for linear waves motion in two layers fluid
Abstrak: The surface wave could be considered as a wave that separates two fluids, namely water and air. Based on this assumption, it is introduced the interfacial wave, a wave between two layers of fluid with different density. The formulation of interfacial waves motion begins with deriving the base equation of irrotational ideal fluid. Furthermore, according to irrotational fluid assumption, the base equation can be stated in velocity potential. In this derivation, the fluids domain is assumed to be restricted by rigid lid boundary conditions, both at the upper and lower limit. Therefore, the interfacial waves motion can be explained in a hamiltonian formulation. In the hamiltonian formulation, total energy is defined as the sum of kinetic and potential energy. The hamiltonian system is obtained from reduction of kinetic energy by using the Dirichlet Neumann Operator. The resulted kinetic energy equation is nonlinear. Therefore, this form is linearized by first part of the Taylor expansion. This linearization gives a dispersion relation of linear wave. Based on this dispersion relation, the phase speed of the linear wave depends on the density ratio of the two layers fluid.
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