Judul: Pemastian khasiat dan identitas kimia jamu terprediksi antihiperkolesterolemia
Abstrak: Khasiat jamu disebabkan oleh aktivitas farmakologi tanaman penyusunnya. Formula jamu sekurang-kurangnya tersusun oleh tanaman utama yang menjadi target khasiat dan tanaman pendukung yang berperan sebagai antiinflamasi, antibakteri, dan analgesik. Dalam penelitian ini, formula jamu baru antihiperkolesterolemia diformulasikan menggunakan pendekatan statistik, yaitu partial least square discriminant analysis, koefisien multiways, dan support vector machine. Formula yang menunjukkan khasiat disorder of appetite pada ketiga metode diuji secara eksperimen. Uji in vivo dilakukan pada ikan zebra yang diinduksi kolesterol menggunakan kuning telur bebek. Berikutnya, metode kromatografi lapis tipis (KLT) dan kromatografi cair kinerja tinggi (KCKT) digunakan untuk menghasilkan profil sidik jari formula jamu. Formula yang dihasilkan terdiri atas jati belanda, kumis kucing, mahkota dewa, dan bangle. Hasil penelitian menunjukkan bahwa formula jamu dapat menurunkan kadar kolesterol darah ikan zebra hiperkolesterolemia selama perlakuan. Jamu F2 memiliki efek yang lebih besar dibandingkan F9. Analisis KLT jamu dengan fase gerak komposisi 2 menghasilkan pola kromatogram yang dapat digunakan sebagai sidik jari formula jamu. Hasil analisis dengan KCKT menunjukkan kadar kuersetin pada jamu F2 lebih tinggi dibandingkan pada F9.
Keyword: antihypercholesterolemic, fingerprint, jamu formulations, zebrafish

Judul: Formulasi Jamu Baru Antikolesterol Melalui Studi Bioinformatika Pangkalan Data Jamu dengan Ikan Zebra sebagai Hewan Model
Abstrak: Jamu formulation is based on pharmacological activity of the constituents. New jamu formula consisting of three supporting plants (analgesic, antibacterial, and antiinflammatory) and the main plant becoming efficacy target (anticholesterol). This new jamu was formulated using PLS (partial least square) with R-Gui software version 2.15.2 generated formula consisting of a mixture of Merremia mammosa tubers, leaves of Guazuma ulmifolia, Orthosiphon stamineus, and Murraya paniculata as the main plant. The formula was tested on zebrafish. The tested jamu formula were jamu formula 1 consisting of a mixture of the four plants with main plant as the most component and formula 2 with the main plant as single component. The total cholesterol average of zebrafish under normal condition was 220 mg/dL (p>0.05), while on the hypercholesterolemia condition was 272 mg/dL (p>0.05). After giving the extract for 7 days, formula 2 lowered total cholesterol greater than that of the formula 1; however, those values were not significantly different at the alpha value (p>0.05).
Keyword: zebrafish, total cholesterol, jamu formulations, anticholesterol

Judul: Implementation of Spatio-Temporal Change Query in Relational Database.
Abstrak: Geographic object changes in various views. Object changes are recorded using a model of static storage. No historical connection between old version data and new version data has been built. For that, a storage model of spatio-temporal queries that can analyze spatio-temporal changes has been developed. The object changes the geometry are grouped according to the taxonomy of Spatio-Temporal Pattern Change. This research has been able to apply the query patterns change including born, expand, merge, contract, split, normal and die. This query based on geometric (area) changes. The implementation of spatio-temporal change queries represents an object changes continuously with easy, change detection is done by comparing two versions of data. Keyword: spatio-temporal change query, spatio-temporal change pattern.
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