Judul: Daya Hambat Siklooksigenase-2 oleh Campuran Ekstrak Suruhan (Peperomia pellucida) dan Jahe Merah (Zingiber officinale) dalam Inflamasi
Abstrak: Peperomia pellucida and Zingiber officinale were known to have anti-inflammatory activity, yet there was no further research to verify their inhibition in inflammatory process. The aim of this research is to test the potency of mixture extract of suruhan (Peperomia pellucida) and red ginger (Zingiber officinale) as anti-inflammation through in vitro inhibition of cyclooxygenase-2 enzyme. Anti-inflammatory effect was analyzed with ELISA (Enzyme Linked Immunosorbent Assay) and spectrophotometry method at wavelenghth 412 nm. Maximum inhibition of Peperomia pellucida extract against cyclooxygenase-2 was 48% at 100 μg/mL, Zingiber officinale extract inhibition was 44% at 300 μg/mL, and for mixture extract inhibition was 15% at 175 μg/mL. Mixture extract of Peperomia pellucida and Zingiber officinale showed lower inhibitory potency to cyclooxygenase-2 compared to their single extracts. Cytotoxicity test with Brine Shrimp Lethality Test method showed that Peperomia pellucida extract, Zingiber officinale extract, and mixture extract of both plants have a cytotoxity effect with each LC50 values are 339, 591, and 728 μg/mL. Phytochemical test showed that each extract contains flavonoid, phenolic, alkaloid, and tannin. Saponin and steroid were contained only in Peperomia pellucida extract and terpenoid was contained only in Zingiber officinale extract. Rendement extract of Peperomia pellucida is 24% and Zingiber officinale is 21%.
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Judul: Penghambatan Enzim Siklooksigenase-2 oleh campuran nanopartikel ekstrak Suruhan (Peperomia pellucida) dan Jahe Merah (Zingiber officinale)
Abstrak: Both suruhan (Peperomia pellucida) and red ginger (Zingiber officinale) were known to inhibit cyclooxygenase-2 but, the mixture of these two has a low inhibition of cyclooxygenase-2. The aim of this research is to test the potency of suruhan, red ginger, and its mixture in nanoparticle as a cyclooxygenase-2 inhibitor. Groups were divided into suruhan nanoparticle, red ginger nanoparticle, and suruhan-red ginger nanoparticle 1:1, 2:1, and 1:2. Nanoparticle was made using homogenation and ultrasonication. The inhibitory effect was analyzed using Enzyme-linked Immunosorbent Assay (ELISA) principle. The average size of suruhan nanopaticle was 90.61 nm and the Polidispersity Index was 0.22. Average size of red ginger nanoparticle was 173.46 nm and IP was 0.17. Maximum inhibition of cyclooxygenase-2 by nanoparticle of red ginger was 73.82% at 75 μg/mL, and 22.99 % by its mixture at 175.75 μg/mL. Nanoparticle of suruhan did not have an inhibitory effect, however its mixture with nanoparticle of red ginger (1:2) can inhibit cylooxygenase-2.
Keyword: Bogor Agricultural University (IPB), suruhan, red ginger, nanoparticle, inflammation, cyclooxygenase-2

Judul: Construction of Strongly Optimal Binary Linear Code with Minimum Distance 9 and 11
Abstrak: A binary linear code of length n over q F is a subspace of n q F . A code has three parameters that attached to it, namely length, dimension, and minimum distance. A code with length n, dimension k and minimum distance d is often called [n, k, d ]-code. Usually, when two parameters are given, then we want to find a code that has the best value for the last parameter. Based on Gilbert- Varshamov bound, if a [n, k, d ]-code exists and can not be expanded, we call it a strongly optimal code. In this paper, we construct strongly optimal code with minimum distance 9 and 11. In constructing the code, we created a theorem and algorithm based on Gilbert-Varshamov bound before we implement the algorithm to MAPLE programming language. Because of computational limitations, the program can only construct up to k = 10 for d = 9 and k = 12 for d = 11.
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