Judul: Hematological Profiles of Dogs Received Single Dose of Sarolaner Anti-Ticks Drug, Hematological Profiles of Dogs Received Single Dose of Sarolaner Anti-Ticks Drug
Abstrak: ABSTRAK NURMASITA. Profil Hematologi Anjing Setelah Pemberian Obat Anti Caplak Sarolaner Dosis Tunggal. Dibimbing oleh ANITA ESFANDIARI DAN SUPRATIKNO. Sarolaner merupakan obat baru anti caplak golongan isoksazolin yang efektif melawan infestasi caplak pada anjing. Penelitian ini bertujuan untuk mempelajari profil hematologi anjing yang diberi obat anti caplak berbahan aktif sarolaner dosis tunggal. Sebanyak lima ekor anjing bercaplak digunakan dalam penelitian ini. Anjing diberi obat anti caplak berbahan aktif sarolaner dengan dosis tunggal sebesar 2 mg/kg BB secara oral. Sampel darah diambil dari vena cephalica antebrachii sebelum diberikan sarolaner (H0, pre-treatment), pada H+7 (7 hari post-treatment), dan pada H+30 (30 hari post-treatment) untuk dianalisis terhadap parameter hematologi meliputi jumlah eritrosit, kadar hemoglobin, nilai hematokrit, dan indeks eritrosit (nilai MCV dan MCHC). Hasil pengamatan menunjukkan bahwa terdapat perbedaan nyata pada nilai hematokrit pada H+7 dan H+30 (P<0.05), namun tidak ada perbedaan nyata pada jumlah eritrosit, kadar hemoglobin, nilai MCV dan nilai MCHC (P>0.05) pada periode waktu yang sama. Pemberian obat anti caplak berbahan aktif sarolaner dosis tunggal sebesar 2 mg/kgBB pada anjing bercaplak mampu meningkatkan rataan nilai hematokrit pada hari ke-7 dan 30 setelah pemberian. Kata kunci: anjing, caplak, profil hematologi, sarolaner., ABSTRACT NURMASITA. Hematological Profiles of Dogs Received Single Dose of Sarolan- er Anti-Ticks Drug. Supervised by ANITA ESFANDIARI and SUPRATIKNO. Sarolaner is a new anti-tick from the isoxazoline group, effective against tick infestations in dogs. The objective of this study was to read the hematological profile of dogs that were given a single dose of anti-tick with sarolaner active in- gredient. There are five ticked dogs used in this study. Anti-tick were given to the dogs with sarolaner active ingredient in a single dose of 2 mg/kg body weight via oral. Blood samples were taken from the cephalic antebrachial vein. The samples were taken before being given a sarolaner (H0, pre-treatment), at H+7 (7days post-treatment), and H+30 (30 days post-treatment). The samples were analyzed for hematological parameters, including the number of erythrocytes, hemoglobin level, hematocrit value, and erythrocyte index (MCV and MCHC values). The re- sults showed that there was a significant difference in the hematocrit value at H+7 and H+30 (P<0.05), but there was no significant difference in the number of erythrocytes, the level of haemoglobin, MCV values, and MCHC values (P>0.05) in the same period. The administration of anti-tick with sarolaner active ingredient in a single dose of 2 mg/kg BW in ticked dogs increased the average hematocrit value on the 7th and 30th days after administration. Keywords: dog, hematological profile, sarolaner, tick.
Keyword: dog, hematological profile, sarolaner, tick

Judul: Leukogram pada Anjing yang Diberi Sediaan Obat Anti Caplak Berbahan Aktif Sarolaner Dosis Tunggal.
Abstrak: Penelitian ini bertujuan untuk mempelajari profil leukogram pada anjing yang diberi obat anticaplak berbahan aktif sarolaner dosis tunggal. Sebanyak 5 ekor anjing bercaplak, umur 1,5 sampai 4 tahun dengan berat badan antara 8 sampai 24,8 kg digunakan dalam penelitian ini. Anjing diberi obat anti caplak berbahan aktif sarolaner dengan dosis tunggal sebesar 2 mg/kg BB per-oral. Sampel darah diambil dari vena cephalica antibrachii sebelum diberikan sarolaner pada H0 (pretreatment), pada H+7 (7 hari post-treatment), dan pada H+30 (30 hari posttreatment) untuk dianalisis terhadap leukogram (jumlah total leukosit, neutrofil, limfosit, monosit, eosinofil, dan basofil). Hasil pengamatan menunjukkan tidak ada perbedaan nyata pada jumlah total dan diferensiasi leukosit (P>0,05). Pemberian obat anticaplak berbahan aktif sarolaner dengan dosis tunggal sebesar 2 mg/kg BB per-oral pada anjing bercaplak tidak memengaruhi jumlah total dan diferensiasi leukosit., The objective of this study was to study the number of total and differential leukocyte profiles of dogs received a single dose of tick repellant with sarolaner active ingredient. There are five ticked dogs used in this study. Tick repellants were given to the dogs with sarolaner active ingredient in a single dose of 2 mg/kg body weight orally. Blood samples were taken from the cephalic antebrachial vein. The samples were taken before being given a sarolaner (H0, pre-treatment), at H+7 (7days post-treatment) and H+30 (30 days post-treatment). The samples were analyzed for the number of total and differential leukocyte (neutrophil, lymphocyte, monocyte, eosinophil, and basophil). The results showed that there was no significant differences in the number of total and differential leukocyte at H+7 and H+30 (P>0,05). The administration of sarolaner active ingredient in a single dose of 2 mg/kg body weight orally in ticked dogs did not affect the number of total and differential leukocytes on the 7th and 30th days after administration.
Keyword: dog, differential leukocyte, sarolaner, tick, total leukocytes count

Judul: Construction of Strongly Optimal Binary Linear Code with Minimum Distance 9 and 11
Abstrak: A binary linear code of length n over q F is a subspace of n q F . A code has three parameters that attached to it, namely length, dimension, and minimum distance. A code with length n, dimension k and minimum distance d is often called [n, k, d ]-code. Usually, when two parameters are given, then we want to find a code that has the best value for the last parameter. Based on Gilbert- Varshamov bound, if a [n, k, d ]-code exists and can not be expanded, we call it a strongly optimal code. In this paper, we construct strongly optimal code with minimum distance 9 and 11. In constructing the code, we created a theorem and algorithm based on Gilbert-Varshamov bound before we implement the algorithm to MAPLE programming language. Because of computational limitations, the program can only construct up to k = 10 for d = 9 and k = 12 for d = 11.
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