Judul: Lipid Peroxide Concentration in The Liver of Hyperlipidemic Rabbits Treated by Hypolipidemic Substance.
Abstrak: Degenerative disease has caused the highest mortality in the world. The disease may occur due to our life style which prefer fast food than traditional one and overeating resulted in hyperlipidemic. This condition will increase lipid peroxidation caused by free radicals in the body such as in the liver. The objective of this research is to determine the influence of hypolipidemic substance on lipid peroxide in the liver of hyperlipidemic rabbits. Twenty four male New Zealand White rabbits were divided into four group: group I (normal), group II (Hyperlipidemic), group III (mixture of Jati Belanda), and group IV (lovastatin). Lipid peroxide concentration was measured by TBA (thiobarbiturit acid) assay that measure malondyaldehida (MDA) as product of lipid peroxidation using spectrophotometer at λ = 532 nm (Yagi et al 1994). The result of the research showed that feeding rabbits with chow contains 0.5% cholesterol and 5% of palm oil caused hyperlipidemic. Lipid peroxide concentration of rabbit’s liver in group II increased two times compared with group I. Group III and IV had lower lipid peroxide concentration of rabbit’s liver compared with group II which is 58.83% and 49.06%. This data showed that Jati Belanda leave mixture and lovastatin decreased lipid peroxidation in the liver.
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Judul: Proses Peroksidasi Lipid Kelinci yang Hiperlipidemia pada Pemberian Senyawa Penurun Kolesterol
Abstrak: Free radicals, such as lipid peroxide, are having much attention right now because their significant role in degenerative disease. Hyperlipidemia is one of the major risk factor for atherosclerosis and lead to degenerative disease. The aim of this study was to determine the effect of cholesterol lowering substance to the blood peroxide lipid concentration in hyperlipidemic rabbit. Twenty four male New Zealand white rabbits were divided into four groups: normal (given standard rabbit feed), hyperlipidemia (given atherogenic rabbit feed contained 0.5% cholesterol and 5% coconut oil), lovastatin (given mixture of atherogenic rabbit feed and lovastatin 57 mg/day), and extract (given atherogenic rabbit feed and jati belanda leaves extract mixture). Thiobarbitnric acid (TBA) method was used in blood lipid peroxide analysis, measuring the MDA product by spectrophotometer at 532 nm. The result showed that the atherogenic rabbit feed caused the elevation of MDA concentration, which means the elevation of lipid peroxidation process. Blood lipid peroxide concentration in hyperlipidemia group increased 163.76% compared with normal group (1.30 ± 0.38 nmol/ml). Lovastatin and jati belanda leaves extract mixture can act as antioxidant which can lowering blood lipid peroxide concentration 46.92% and 53.03% respectively at 8th week compared with hyperlipidemia group.
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Judul: Metrik Einstein (Anti-) Self-Dual Berdimensi Empat dengan Metode Cartan
Abstrak: Gravitational field equation can be formulated in differential forms (differential geometry), which describes gravity as a manifestation of the curvature of space-time. Curvature of space-time is characterized by a metric that satisfies the gravitational field equation. With differential forms it can be formulated the (anti-) self-dual Einstein equation, which is a modification of the Cartan structure in (anti-) self-dual basis. Calculation of (anti-) self-dual metric with (anti-) self-dual Einstein equation is simpler than the calculation using Christoffel symbols.
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