Judul: Analisis spasial kabupaten agam dalam kaitannya dengan kesenjangan pembangunan antar wilayah
Abstrak: Kabupaten Agam sebagai salah satu kabupaten di Provinsi Sumatera Barat secara geografis terletak antara 000 01’ 34” s/d 000 28’ 43” Lintang Selatan dan 990 46’ 39” s/d 1000 32’ 50” Bujur Timur dengan luas wilayah 2 212.19 km2 yang berarti hanya 5.26 persen dari luas Provinsi Sumatera Barat yang mencapai 43 229.04 km2. Terbagi atas empat wilayah berdasarkan topografinya yaitu: 1) wilayah datar dengan kemiringan 00 - 30 dengan luas 662 Km2; 2) wilayah datar berombak dengan kemiringan 30 - 80 dengan luas 153 Km2; 3) wilayah berombak dan bergelombang dengan kemiringan 80 - 150 dengan luas 801 Km2; dan 4) wilayah bukit bergunung dengan kemiringan 150 lebih dengan luas 616 Km2. Terbagi tiga wilayah atas penggunaan lahan existing, meliputi:1) Agam Barat, wilayah perkebunan; 2) Agam Tengah, wilayah kehutanan; dan 3) Agam Timur, wilayah pertanian. Sedangkan berdasarkan aksesibilitas dan orientasi pergerakan dibagi dua wilayah: 1) barat didominasi pergerakan antar kabupaten dan lokal, dan 2) timur didominasi pergerakan antar propinsi dengan orientasi Padang- Bukittinngi-Riau.
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Judul: Analisis spasial disparitas pembangunan antar wilayah di provinsi Sumatera Barat
Abstrak: The phenomenon of disparity areas have become commonplace in the development of an area for various reasons. Development of region in the province of West Sumatra by naked eye there is a disparity in the region indicated. The objectives of this research are 1) determine the amount of disparity in development between regions, 2) identify the sectors held by each district / city; 3) determine the level of development and regional characteristics; 4) analyze the factors that cause disparities in development among regions; 5) to formulate strategies to address the problem of regional development disparities. Analytical methods used are Williamsons Index, Theill Index, Location Quotient Index, Shift Share Analysis, Scalogram Method, Entropy Index, Physical Analysis, Klassen Typology, Factor Analysis, Multiple Regression, and SWOT analysis. The analysis showed there are gaps in the province of West Sumatra which occurs predominantly among areas within the territory of the border region. Dominant sector in the district are agriculture, while in urban areas is service sector. The main factor that caused the region is an indicator of economic inequality and population indicators. The strategies that can be used to overcome the inequality are in development of other sectors of the economy of the agricultural sector and the optimization of the center point of growth and service center region.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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