Judul: Potensi Antihiperkolesterolemia Ekstrak Seduhan Teh Herbal Lempuyang Gajah (Zingiber zerumbet L.)
Abstrak: The objective of this research was to study the effectivity of herbal tea compositions of lempuyang gajah as antihypercholesterolemic agent. Extracts were tested in Sprague-Dawley male rats. Forty six rats were divided into four experimental groups as follow: normal, hyperlipidemic, herbal tea extract 1, and herbal tea extract 2. Rats were made hiperlipidemic by oral administration of propil tiouracil (0.5 mg/Kg BW) and high cholesterol feeding (1.5 % cholesterol). Total blood cholesterol concentrations were measured by cholesterol oxidase enzymatic methods of ‘CHOD-PAP’ using spectrophotometer at wavelenght 500 nm. Results showed that cholesterol diet increased blood cholesterol concentration by 76.11 % (p=0.004). Following free cholesterol diet (washed out period), blood cholesterol concentration was decreased by 43.82 % (p=0.101). Similarly, extract 1 reduced cholesterol concentration by 43.20 % (p=0.005). Antihyperlipidemic potency of extract 2 is higher than extract 1 as shown by significant reduction of cholesterol by 51.70 % (p=0.000).
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Judul: Teh herbal lempuyang gajah sebagai penurun lipid peroksida darah tikus hiperkolesterolemia
Abstrak: The lempuyang gajah herbal tea has been reported to reduce blood cholesterol concentration, but reports on its potency to reduced blood lipid peroxide concentration is not known. The objective of this research is to determine the potency of this mixture of lempuyang gajah (Zingiber zerumbet L.) and green tea (Camellia sinensis) as antioxidant in vivo, particularly in hypercholesterolemic condition. Twenty six rats were divided into normal group and cholesterol feed group. Cholesterol feed group (HK) were divided into 3 groups: hypercholesterolemic (HK I), herbal tea dosage 1 (HK II), herbal tea dosage 2 (HK III). Hypercholesterolemia was induced by cholesterol diet (1.5%) and PTU (0.01%) administered orally for 6 weeks. Afterward, animals were given cholesterol free standard diet. Extract of herbal tea were administered orally for another 4 weeks with dosage of lempuyang gajah:green tea= 1:2 (dosage 1) and 2.5:2 (dosage 2). Lipid peroxide concentration was analyzed in week-0,2,4,6,8, and 10 using spectrophotometry method at 533 nm. Cholesterol fat and PTU induction significantly (p<0.05) increased lipid peroxide concentration in blood of HK (40.31%) compared with normal group. Reduction in blood lipid peroxide concentration of HK III was more (40.50%) than HK II (32.57%) at the end of experiment.
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Judul: Transisi Fasa Materi Hadronik ke Materi Kuark pada Inti Bintang Neutron.
Abstrak: Bintang neutron terdiri dari beberapa lapisan yang disusun oleh materi nuklir yang berbeda dengan kerapatan yang semakin tinggi ketika mendekati pusat bintang. Inti luar bintang neutron disusun oleh materi hadronik (nukleon, lepton, dan hyperon), sedangkan inti dalam bintang neutron disusun oleh kuark-kuark bebas (up, down, strange) yang saling berinteraksi. Tujuan penelitian ini adalah mempelajari bagaimana transisi dari inti luar ke inti dalam bintang neutron dengan menggunakan pendekatan RMF (Relativistic Mean Field) untuk materi hadronik dan CIDDM (Confined Isospin Density Dependent Mass) untuk materi kuark. Tekanan transisi diperoleh ketika potensial kimia barion materi hadronik dan materi kuark bernilai sama. Nilai tekanan transisi dengan parameter SU6-TM1 sekitar 87 MeV/fm3 dan diperoleh massa maksimum bintang neutron yaitu 1.92M dengan jari-jari sekitar 8.62 km. Nilai tekanan transisi dengan parameter SU6-G2 sekitar 53 MeV/fm3 dan massa maksimum bintang neutron yaitu 1.88M dengan jari-jari sekitar 8.16 km. Jenis transisi fasa adalah orde satu ditandai dengan diskontinuitas dalam kerapatan energi (adanya mixed phase). Parameter-parameter pada model nuklir yang digunakan menyebabkan perbedaan kekakuan persamaan keadaan (EOS) dari materi hadronik dan materi kuark sehingga nilai tekanan transisi dari fasa hadronik ke fasa kuark juga berbeda.
Keyword: bintang neutron, persamaan keadaan, transisi fasa