Judul: Strategi Pengembangan Obyek Wisata Pantai Bonang-Binagun di Kabupaten Rembang, Provinsi Jawa Tengah
Abstrak: Sektor pariwisata bahari merupakan salnh satu potensi yang bisa menjadi andalan bagi daerah-daerah pesisir di Indonesia dalam inienghactapi otonomi daerah saat ini termasuk diantaranya adaiah Kabupaten Rembang. Salah satu kawasan yang berpotensi untuk dikembangkan sebagai obyek wisata pantai di Kabupaten Rembang adalah Pantai Bonang-Binangun. Dalam rangka mencapai peningkatan perekonomian masyarakat dan alokasi pemanfaatan ruang yang optimal pemerintah berkeinginan untuk menata dan mengembangkan kawasan Pantai Bonang-Binangun.
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Judul: Analisis Kebijakan Pengembangan Kawasan Bahari Terpadu Kabupaten Rembang Jawa Tengah
Abstrak: Sebagai negara maritim, Indonesia memiliki swnberdaya pesisir dan laut yang berlimpah dan belum dimanfaatkan secara optimal bagi sebesar-besamya kemakmuran rakyat Pembangunan sumberdaya pesisir dan laut pada saat ini menjadi andalan bagi bangsa Indonseia untuk me1akukan pemulihan ekonomi. Sesuai dengan kebijakan otonomi daerah, maka pengelolaan sumberdaya pesisir dan laut akan lebih banyak diserahkan kepada pemerintah daerah. Hal ini tentu saja memberikan peluang yang lebih besar bagi daerah untuk mengelola dan memanfaatlcan potensi pesisir dan kelautannya bagi kesejahteraan masyarakat. ...
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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