Judul: Antihypercholesterolemic Potency of Kayu Gabus bark (Alsonia scholaris, R.Br.)
Abstrak: Kayu Gabus (Alstonia scholaris, R Br.) grows in Indonesia and its water extract (so called infusarium) has been used as traditional medicine. Its activity as antihyperchole.sterolemic has not been studied scientifically. The present study was carried out from 1995 to 1999. The aims of this study are to (1) determine the effect of infusarium and solvent fraction of Kayu Gabus bark on serum total cholesterol level of hypercholestmlemic Wistar male rat, (2) to study effect of Kayu Gabus bark infusarium and solvent fraction treatment on profile of LDL-cholesterol, HDL-cholesterol, triglyceride and fatty liver of Wistar male rat, (3) determine effect of solven. M o n treatment on endogenous cholesterol biosynthesis activity and on cholesterol secretion through feces of hypercholesterolernic Wistar male rat, and (4) to classify the compound in solvent hction having antihypercholesterolemic activity.
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Judul: The potency of mahogany bark as a lower of blood cholesterol hipercholesterolemia white rats.
Abstrak: Salah satu tumbuhan yang diyakini berkhasiat sebagai tumbuhan obat untuk menurunkan kolesterol darah adalah mahoni (Swietenia macrophylla King.). Penelitian ini bertujuan menguji khasiat ekstrak kulit kayu mahoni sebagai penurun hiperkolesterolemia secara in vivo pada tikus galur Sprague Dawley. Sebanyak 25 ekor tikus jantan dibagi menjadi 5 kelompok (n=5), yaitu kelompok normal (N) diberi pakan standar, kelompok hiperkolesterolemia (HK) diberi pakan kolesterol (1.5%) dan propil tiourasil (PTU) (0.5mg/KgBB), kelompok lovastatin (HK+lovastatin 0.2875 mg/kgBB), kelompok perlakuan ekstrak 1/ E1 (HK+ekstrak air mahoni 150 mg/kgBB), serta kelompok perlakuan ekstrak 2/ E2 (HK+ekstrak air mahoni 300 mg/KgBB). Masa percobaan berlangsung selama 7 minggu, dibagi menjadi 2 periode yaitu peningkatan kolesterol selama 6 minggu dan perlakuan ekstrak kulit kayu mahoni selama 1 minggu. Konsentrasi kolesterol total darah dianalisis setiap 2 minggu dengan metode enzimatik kolesterol oksidase CHOD-PAP (cholesterol oxidase phenol amino phenanzone ) yang diukur dengan spektrofotometer pada panjang gelombang 505 nm. Hasil penelitian menunjukkan pemberian pakan kolesterol (1.5%) dan PTU (0.5 mg/kgBB) selama 7 minggu pada kelompok HK mampu menaikkan konsentrasi kolesterol sebesar 245.50%. Analisis statistik mendukung bahwa kelompok E2 signifikan terhadap kelompok HK dan tidak signifikan terhadap kelompok normal. Sementara dosis ekstrak 150 mg/kgBB tidak berbeda nyata dengan HK. Berdasarkan data dapat disimpulkan bahwa kelompok E2 mampu menurunkan konsentrasi kolesterol.
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Judul: Metrik Einstein (Anti-) Self-Dual Berdimensi Empat dengan Metode Cartan
Abstrak: Gravitational field equation can be formulated in differential forms (differential geometry), which describes gravity as a manifestation of the curvature of space-time. Curvature of space-time is characterized by a metric that satisfies the gravitational field equation. With differential forms it can be formulated the (anti-) self-dual Einstein equation, which is a modification of the Cartan structure in (anti-) self-dual basis. Calculation of (anti-) self-dual metric with (anti-) self-dual Einstein equation is simpler than the calculation using Christoffel symbols.
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