Judul: Persepsi Birokrat Tentang Otonomi Bidang Kehutanan (Kasus di Provinsi Sulawesi Selatan, Kalimantan Barat dan Sumatera Utara)
Abstrak: Penelitian ini diarahkan untuk melihat bagaimana persepsi para pelaksana pembangunan kehutanan di derah (kabupaten) pada awal pelaksanaan otonomi daerah (desentralisasi), karena pada awal berlakunya otonomi daerah telah muncul isu (sampai tahap nasional) perbedaan persepsi tentang otonimi termasuk otonomi (desentralisasi) kehutanan yang cukup mengkhawatirkan perkembangan kelestarian hutan di Indonesia.
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Judul: Kajian Proses Pembaharuan Kebijakan Pengelolaan Hutan Dalam Rangka Otonomi Daerah Kabupaten Kutai Barat Propinsi Kalimantan Timur
Abstrak: Penelitian bertujuan untuk melakukan kajian faktor pendorong dan penghambat terhadap proses pembaharuan kebijakan pengelofaan hutan dalam rangka implementasi otonomi daerah kabupaten Kutai Barat propinsi Kalimmtan Timur. Pembaharuan kebijakan dan kinerja pengelolaan hutan dapat tercapai, apabila faktor pendorong lebih besar dari pada faktor penghambatnya, dan kebijakan dapat dilaksanakan apabila rumusan operasionalnya sesuai dengan harapan rasional para pihak terkait atas kinerja insitusi pengelolaan hutan.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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