Judul: Efek pemberian Poly-Unsaturated Fatty Acids (PUFA) intravena terhadap integritas mukosa lambung pada beruk (Macaca nemestrina) dengan ikterus obstruktif
Abstrak: Acute gastric mucosal injury commonly occurs in patients with obstructive jaundice. Some proposed pathogenic mechanism of acute mucosal gastric injury in obstructive jaundice has been reported. We studied the effect of intravenous poly-unsaturated fatty acids (PUFA) administration on gastric mucosal integrity in pig-tailed macaques (Macaca nemestrina) with obstructive jaundice by ligating common bile duct (CBD). In this study, eight selected male pig-tailed macaques with the body weight between 5,5-7,5 kg (with the average of 6,625±0,83 kg) were used and divided randomly into two groups. In both groups, laboratory examination (including liver function tests, lipid profile, prothrombine time, gastric mucosal level of lipid peroxide and glutathione) and upper gastrointestinal endoscopy were performed before CBD ligation and every two weeks after ligation. In the first group intravenous PUFA with the dose of 2 g/day was administered every day since four weeks post ligation up to four weeks later, and in the second group intravenous PUFA was administered since before ligation up to eight weeks later. In both groups, total bilirubin, direct bilirubin, indirect bilirubin, SGOT, SGPT, alkaline phosphatase, GGT, globulin, total cholesterol and trigliseride were clearly increased, meanwhile albumin level were clearly decreased. Cholinesterase, prothrombine time and gastric mucosa level of lipid peroxide and glutathione in both groups were not changed. Ulcer formation occured among the first group during four weeks after CBD ligation, and these ulcers were clearly healed within four weeks after intravenous PUFA administration. Among the second group, there was no significant ulcer formation within eight weeks after CBD ligation. In conclusion, the potential appearance of acute gastric mucosal injury which reflected by gastric ulcer formation was significantly decreased by intravenous PUFA administration in pig-tailed macaques with obstructive jaundice. We also have developed animal model of obstructive jaundice successfully by CBD ligation, based on the result of liver function and lipid profile tests.
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Judul: Potensi fraksi air buah makasar (Brucea javanica (L.) Merr) terhadap gambaran histopatologi pankreas tikus yang diinduksi aloksan
Abstrak: Brucea fruit (Brucea javanica (L.) Merr) is one of Indonesian medicine plants which rich in advantages. Empirically, brucea fruit can decrease blood glucose concentration for patient of diabetes mellitus. This research was aimed to determine the effect of aqueous fraction from ethanolic extract of brucea fruit on histopathological in rat pancreas which induced alloxsan. On this research Sprague Dawley rats were divided into 6 groups, each group were 4 rats, group A (Normal), B (alloxan + Glibenclamide 0.25 mg/kg BB), C (alloxan + aquades), D (alloxan + Brucea fruit water fraction 0.25 mg/kg BB), E (alloxan + Brucea fruit water fraction 25 mg/kg BB), dan F (alloxan + Brucea fruit water fraction 50 mg/kg BB). Pancreas histopathological analysis was carried out with Haematoxylin-eosin (HE) staining and observed under light microscope. Reserch showed that aqueous fraction from ethanolic extract of brucea fruit dosage 0.25 mg/kg BB, 25 mg/kg BB, and 50 mg/kg BB can repair the damage of rat pancreas which induced alloxan 150 mg/kg BB. Aqueous fraction from ethanolic extract of brucea fruit dosage 50 mg/kg BB given better restoration effect on the islets of Langerhans than Glibenclamide.
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Judul: Penerapan Algoritme Genetika dalam Sistem Permainan Tebak Angka
Abstrak: The number guessing game is a modified game of mastermind created by Mordecai Meirowitz in 1970. The goal of the game is to guess a hidden sequence of numbers stored by others (human or computer) based on values obtained at each guess iteration. In this study, the game is applied into the system by using genetic algorithms, a method that has been successfully utilized to implement the mastermind game on the computer and get an effective solution for the game. Genetic algorithms work through a process of natural selection or commonly known as the evolutionary process, which will continue running until the system finds the optimal 4-digit series of numbers. The system is designed in order to guess those hidden numbers with minimal iterations using c++ programming language. The output of the program shows that the performance is determined by the first guess iteration.
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