Judul: Visualization of Amyloidopathy on Renal Mice After Immunized by Amyloid Beta-42
Abstrak: Penyakit Alzheimer merupakan jenis demensia berupa gangguan neurodegeneratif progresif pada lansia, yang ditandai adanya senile plaque dan neurofibrillary tangles di otak. Ginjal merupakan organ vital yang berpotensi mengalami kerusakan akibat retensi amyloid beta-42 (Aβ42). Studi ini dilakukan untuk mengidentifikasi amyloidopathy pada jaringan ginjal mencit yang terbagi menjadi 2 kelompok yaitu mencit yang diimunisasi Aβ42 (n=6) dan kontrol (n=8). Pengamatan histopatologis jaringan ginjal dilakukan dengan pewarnaan Hematoksilin Eosin. Temuan lesio dianalisis secara deskriptif dan semikuantitatif. Berdasarkan pengamatan yang dilakukan, ditemukan lesio patologis peradangan interstisial dengan sel peradangan limfosit, sel plasma, dan makrofag, serta kongesti dan hemoragi pada organ ginjal mencit perlakuan maupun kontrol. Organ ginjal mencit perlakuan yang diamati tidak menunjukkan adanya lesio sklerosis glomerulus, maupun fibrosis interstisial dan atrofi tubulus. Temuan ini diharapkan dapat melengkapi informasi mengenai penggunaan mencit sebagai hewan model penyakit Alzheimer serta membantu dalam pengembangan kit diagnostik. Kata kunci: amiloidosis, ginjal, histopatologi, mencit, penyakit alzheimer, Alzheimer’s disease is a type of dementia in the form of a progressive neurodegenerative disorder that happens in the old age, marked with the existence of senile plaque and neurofibrillary tangles in the brain. Kidneys are the vital organs which may have potential to get affected by the brain damage that is caused by amyloid beta-42 (Aβ42) retention. The aim of this study was to identify the amyloidopathy on mice renal tissues which is divided into two groups; the immunized mice by Aβ42 (n=6), and controls (n=8). Histopathological observations of renal tissue were carried out by using Hematoxylin Eosin staining. The lesion findings were then analyzed descriptively and semiquantitatively. Based on the observations, pathological lesions of interstitial inflammation that were filled with lymphocytes, plasma cells, and macrophages inflammatory cells, congestion, and hemorrhage were also identified in both treated and control mice renal tissues. The observed renal organs on the treated mice did not show glomerular sclerosis lesions, nor interstitial fibrosis and tubular atrophy. These findings are expected to complete the information regarding the use of mice as model organism of Alzheimer’s disease (AD) and assist in developing a diagnostic kit for AD. Keywords: alzheimer’s disease, amyloidosis, histopathology, kidneys, mice.
Keyword: amiloidosis, ginjal, histopatologi, mencit, penyakit alzheimer, alzheimer's disease, amyloidosis, histopathology, kidneys, mice

Judul: Overview of Potential Amyloidopathy in Renal Mice (Mus musculus) After Injected by Amyloid Beta 40 and 42
Abstrak: Penyakit alzheimer merupakan gangguan neurodegeneratif yang ditandai dengan penurunan fungsi serta kerusakan pada jaringan otak secara permanen. Penyakit alzheimer akan bertambah kronis seiring berjalannya waktu dan hingga saat ini belum ditemukan obat yang dapat menyembuhkan penyakit ini. Penelitian ini bertujuan mengetahui perubahan yang terjadi pada organ ginjal mencit secara histopatologi setelah disuntikan dengan antigen Aβ 40 dan Aβ 42 sebagai marka dari penyakit neurogeneratif tipe Alzheimer. Sepuluh ekor mencit Balb/c (kontrol n=2, Aβ40 n=4, Aβ42 n=4) berumur 6 minggu digunakan dalam penelitian ini. Mencit dinekropsi kemudian diambil organ ginjalnya untuk dijadikan preparat histopatologi dengan pewarnaan Hematoksilin Eosin. Variabel yang diamati berupa adanya perubahan pada sel-sel ginjal dan data dianalisa secara deskriptif. Hasil pengamatan terhadap perubahan patologi terhadap sel-sel organ ginjal mencit memperlihatkan adanya lesi berupa pelebaran ruang bowman dan degenerasi hidropis pada tubulusnya. Penyuntikkan protein Aβ 40 dan 42 menyebabkan kerusakan pada sel-sel tubulus ginjal mencit.
Keyword: Alzheimer’s disease, Amyloid-Beta 40, Amyloid Beta 42, Renal Histopathology

Judul: Identifikasi Fluktuasi Ketinggian Tropopause di Kawasan Pasifik Tropis
Abstrak: The 30-years (January 1981 – December 2010) ERA-Interim data issued by ECMWF (Europe Center for Medium Range Weather Forecasting) is used for identifying tropopause height fluctuation in tropical Pacific region. Principle component and spectral analysis is done in order to identify the main pattern of tropopause height fluctuation as generator in the region. The result has shown that the predominant fluctuation trigger is periodical 45-month ENSO. Meanwhile insolation fluctuation due to earth orbital position has placed second with 12- month period after ENSO occurrence. The 20-month oscillation period of QBO (Quasi Biennial Oscillation), periodical 6-month variation of SAO (Semi Annual Oscillation), and 6-month period of MJO (Madden Jullian Oscillation) give weaker influence on tropopause height fluctuation in the region than that of ENSO and insolation. Eigen vector distribution from principle component shows that these five oscillations are very influential and dominant in tropical west Pacific as response of interaction of the five oscillations with Walker circulation in tropical Pacific.
Keyword: Bogor Agricultural University (IPB), Spectral, Walker circulation, Tropopause height fluctuation, Principle component analysis