Judul: Efek pemberian Poly-Unsaturated Fatty Acids (PUFA) intravena terhadap integritas mukosa lambung pada beruk (Macaca nemestrina) dengan ikterus obstruktif
Abstrak: Acute gastric mucosal injury commonly occurs in patients with obstructive jaundice. Some proposed pathogenic mechanism of acute mucosal gastric injury in obstructive jaundice has been reported. We studied the effect of intravenous poly-unsaturated fatty acids (PUFA) administration on gastric mucosal integrity in pig-tailed macaques (Macaca nemestrina) with obstructive jaundice by ligating common bile duct (CBD). In this study, eight selected male pig-tailed macaques with the body weight between 5,5-7,5 kg (with the average of 6,625±0,83 kg) were used and divided randomly into two groups. In both groups, laboratory examination (including liver function tests, lipid profile, prothrombine time, gastric mucosal level of lipid peroxide and glutathione) and upper gastrointestinal endoscopy were performed before CBD ligation and every two weeks after ligation. In the first group intravenous PUFA with the dose of 2 g/day was administered every day since four weeks post ligation up to four weeks later, and in the second group intravenous PUFA was administered since before ligation up to eight weeks later. In both groups, total bilirubin, direct bilirubin, indirect bilirubin, SGOT, SGPT, alkaline phosphatase, GGT, globulin, total cholesterol and trigliseride were clearly increased, meanwhile albumin level were clearly decreased. Cholinesterase, prothrombine time and gastric mucosa level of lipid peroxide and glutathione in both groups were not changed. Ulcer formation occured among the first group during four weeks after CBD ligation, and these ulcers were clearly healed within four weeks after intravenous PUFA administration. Among the second group, there was no significant ulcer formation within eight weeks after CBD ligation. In conclusion, the potential appearance of acute gastric mucosal injury which reflected by gastric ulcer formation was significantly decreased by intravenous PUFA administration in pig-tailed macaques with obstructive jaundice. We also have developed animal model of obstructive jaundice successfully by CBD ligation, based on the result of liver function and lipid profile tests.
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Judul: Studi Toksikopatologi Organ Hati dan Ginjal Mencit (Mus musculus) Akibat Pemberian Berbagai Fraksi Pauh Kijang (Irvingia malayana Oliv. Ex A. Benn).
Abstrak: The aim of this research was to examine the toxicopathology effect from various fractions of Irvingia malayana Oliv. Ex A. Benn on mice liver and kidney. Twenty five male mice age ±3 months with ±30 grams BW used in this research were divided into five group of treatments. Each mice from four groups of treatment was received 100 mg/kg BW fractions of I. malayana from chloroform solvent, ethyl acetate solvent, hexane solvent, and ethanol residue solvent, while one group control received carboxymethocellulose. After receiving 100 mg/kg BW fraction I. malayana for seven days, the mice then were sacrificed, the liver and kidney were sampled and fixed in Buffer Neutral Formalin 10% solution to make histopathology slides with Haematoxylin and Eosin stain. The histopathology slides were observed under light microscope. The lesion observed in the liver and kidney proximal tubular epithelium was degeneration and necrosis/apoptotic. The result from this research indicated that the dose of 100 mg/kg BW fraction of I. malayana from various solvent were not toxic to hepatocytes and proximal tubular epithelium.
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Judul: Desain Sistem Transfer Energi Nirkabel Berbasiskan Tesla Coil
Abstrak: Tesla coil merupakan alat yang ditemukan oleh Nikola Tesla yang dapat mentransmisikan daya tanpa kabel dengan memanfaatkan prinsip induksi elektromagnetik. Pada penelitian ini dibuat sebuah prototype Tesla Coil dengan menggunakan transistor C1970 dan receiver menggunakan rangkaian LC. Identifikasi alat meliputi pengaruh daya input transmitter terhadap receiver, bentuk signal yang dipancarkan transmitter, pengaruh jarak transmitter dan receiver, nilai efisiensi serta efek alat terhadap perangkat lain. Hasil pengamatan menunjukkan bahwa semakin besar daya input maka semakin besar daya yang dipancarkan oleh transmitter. Bentuk sinyal yang dipancarkan oleh transmitter berupa gelombang listrik AC sinusoidal dengan frekuensi ~2.9 MHz. Semakin jauh jarak receiver terhadap transmitter maka semakin kecil amplitudo gelombang AC yang diterima oleh receiver, menyebabkan semakin kecil daya yang diterima oleh receiver. Adapun nilai efisiensi terbesar penangkapan daya oleh receiver yaitu sebesar 0.00516 % serta terdapat gangguan pada alat-alat tertentu seperti monitor komputer dan radio.
Keyword: rangkaian LC, receiver, tesla coil, transistor C1970, transmitter