Judul: Aktivitas Fraksi Kloroform Buah Makasar (Brucea javanica [L.] Merr.) sebagai Inhibitor Enzim α-Glukosidase
Abstrak: Brucea fruit (Brucea javanica (L.) Merr) is a plant used in traditional medicine and proven pre-clinically for antimalaria, antipyretic, anticancer and homeostatic effects. However, the antidiabetic mechanism of this plant has not been elucidated. This research was done to determine the potential of chloroform fraction of brucea fruit at 1, 1.5, 2% as α-glucosidase inhibitor and compared their activities with acarbose 1% as a positive control. Brucea fruits were extracted with ethanol solution of 95% using maceration dan fractination solution method. Chloroform fraction of brucea fruits were used for phytochemical assay and used for α-glucosidase inhibition method. The α-glucosidase activity was determined by measuring the p-nitrophenol release from the reaction of the enzyme and substrate p-nitrophenyl-α-D-glukopiranosida (p-NPG) at wavelength 400 nm. The phytochemical analysis indicates that the chloroform fraction of brucea fruit contain alkaloid, saponin, and tannin. The fraction at concentration 1, 1.5, and 2% (b/v) and acarbose 1% can inhibit α-glucosidase enzyme activity respectively 16.48%, 17.96%, 19.68%, and 81.16%.
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Judul: Aktivitas antihiperglikemia fraksi air buah makasar (Brucea javanica (L.) Merr) pada tikus yang diinduksi aloksan
Abstrak: Brucea fruit (Brucea javanica (L.) Merr) was known to have a potential antidiabetic activity. This research was aimed to determine antihyperglycemic activity of aqueous fraction from ethanolic extract of brucea fruit in alloxan induced rats. Aqueous fraction of ethanolic extract brucea fruit obtained by maseration using ethanol 95%, which then separated using funnel separator with mixed solution of hexane, methanol, and water (5:9:1) and chloroform:water (1:1). Twenty four rats divided into 6 groups. In the process of raising the blood glucose concentration, one of normal group induced by NaCl 0.9% and the other five treatment groups induced by alloxan (150 mg/kg BW). Afterwards, in the treatment process, normal group and negative control administered by aquadest, positive control administered by glibenclamid (0.25 mg/kg BW), and three other groups administered by aqueous fraction of ethanolic extract brucea fruit in dosage 0.25, 25, and 50 mg/kg BW. Blood glucose concentration of the fasting rats measured at day 0, 3,7,11, and 15. Aqueous fraction from ethanolic extract of brucea fruit contained 3.71% in yield. The result showed that aqueous fraction from ethanolic extract of brucea fruit in dosage 0.25, 25, dan 50 mg/kg BW decreased the blood glucose concentration as many 37.64%, 37.43%, and 60.82% respectively. Aqueous fraction of brucea fruit wich is extracted by ethanol in dosage 50 mg/kg BW has higher activity than glibenclamid in dosage 0.25 mg/kg BW (45.53%).
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Judul: Simulasi persamaan keadaan bintang dengan pendekatan klasik dan relativistik
Abstrak: Komposisi bintang yang selalu berubah akanmempengaruhi massa dan radius bintang itu sendiri. Dimana semakin tua sebuah bintang, maka bintang akan didominasi oleh unsur-unsur berat. Dengan persamaan politrop dan metode Runge-Kutta orde 4 didapatkan radius dan massa bintang semakin berkurang seiring berkurangnya nilai Ye, sedangkan kerapatan semakin meningkat. Pendekatan terbaik terdapat pada nilai Ye sebesar 0.5 dimana didapatkan bahwa massa bintang katai putih sebesar 1.4Mo sesuai dengan massa Chandrasekhar dengan radius bintang 5000 km dan nilai kerapatan bintang sebesar 5.31x 106 g cm-3. Untuk massa bintang neutron diperoleh nilai 0.05Modan radius bintang sebesar 2300 km, sedangkan kerapatannya bintang neutron diperoleh sebesar 1.84 x 107 g cm-3 dengan menggunakan pendekatan relativistic. Pendekatan relativistic terbukti lebih baik untuk menentukan radius dan massa bintang, dengan pendekatan terbaik pada nilai Ye sebesar 0.5 yaitu pada bintang katai putih
Keyword: Composition of the stars, density of the stars, mass of the stars, radii of the stars