Judul: Sistem penunjang keputusan pengembangan agroindustri kecil di kawasan agropolitan (studi kasus di Kota Batu, Jawa Timur)
Abstrak: An area called agropolitan area based on top rated commodities is the area which depends on agriculture products and having leading commodities. The area is not only going to be the supplier of the leading agriculture products but also going to produce the processed agriculture products into the market. City of Batu is the rich area for agriculture products and some of them are leading commodities.
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Judul: Kajian kelembagaan agroindustri pangan olahan di kawasan-kawasan agropolitan Kota Batu Provinsi Jawa Timur:
Abstrak: Kota Batu secara geografis memiliki potensi sumberdaya alam yang berlimpah. Untuk dapat memaksimalkan potensi sumberdaya limpahan hasil pertanian, dan dalam upaya menghadapi tekanan angkatan kerja, secara alami masyarakat Kota Batu telah berupaya melakukan optimalisasi pemanfaatan sumberdaya alam sebagai bahan baku agroindustri. Dalam perkembangannya, Sektor Agroindustri terutama untuk sub sektor Makanan dan Minuman terlihat mendominasi sektor Industri Pengolahan di Kota Batu. Kondisi tersebut terlihat pada perkembangan sektor industri pengolahan yang inputnya sebagian besar memanfaatkan hasil dari sektor pertanian daerah setempat. Keberadaan sektor pariwisata yang berkembang pesat di Kota Batu merupakan nilai lebih tersendiri, karena dengan berkembangnya sektor pariwisata ini dapat meningkatkan permintaan yang lebih besar terhadap sektor hilir agribisnis mencakup agroindustri perdesaan, industri manufaktur makanan, pelayanan kebutuhan restoran dan hotel-hotel, hingga outlet-outlet agribisnis maupun toko oleh-oleh dan cindera mata.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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