Judul: Perencanaan lnterpretasi Biota Air di Kawasan Suaka  Margasatwa Muara Angke
Abstrak: Suaka Margasatwa Muara Angke (SMMA) sebagai hutan mangrove merupakan habitat kera ekor panjang, burung-burung merandai, dan berbagai jenis biota air. Sejauh ini, sangat sedikii masyarakat yang mengetahui tentang biota air di SMMA karena belum ada program interpretasi tentang biota air. Peneliian ini bertujuan untuk menyusun rencana interpretasi biota air di SMMA. Tahaptahap perencanaan interpretasi adalah penentuan topik dan tujuan, pengumpulan data, analisis data, sintesis, dan penyusunan rencana.
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Judul: Analisis gap kebijakan pengelolan kawasan suaka margasatwa : Kasus di SM Balairaja, Bengkalis, Riau
Abstrak: Conservation area represents pillar of ecosystem stabilization that gives various protections for ecology processes and a lot of species varieties, as treasure for future that the benefit is still unknown. By now, the big potency that is had by conservation area faces serious threats therefore the area management becomes an urgent agenda. The research objective is to identify and evaluate management policy of SM Balairaja area, also formulate and give policies alternative recommendation of SM Balairaja management. The research was located in Mandau District of Bengkalis Regency at five of study villages: Pematang Pudu, Balairaja, Petani, Pinggir and Tengganau during March until September 2004. Data sources were taken by direct observation and result from researches that were part of “Baseline Study on Balairaja Conservation Area, Riau” supported by PPLH-IPB and PT Caltex Pacific Indonesia. The variety, richness and threat that were faced by vegetation and wild animal described descriptively, social culture activities were identified by FGD method (Focus Discussion Group) and deep interview, then policy alternative used AHP method (Analytical Hierarchy Process). Result showed the variety and richness rare of vegetation and wild animal in SM Balairaja area happened because of government compilation through contradictive codes, also the destructiveness activities involvement of economic social without strict law enforcement since area had been specified as wilderness area. AHP result gave the main policy of priority alternative in area management that was taken by Non government. The focus of program be on society management by management priority on social culture factor. Priority scale that was chosen showing un sensitive to preferences change of PHKA, BKSDA, PT.CPI, LSM, and Society. Beside that, research showed the stakeholders perception was different with the exist codes.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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