Judul: Khasiat Ekstrak Kulit Kayu Mahoni (Swietenia macrophylla King.) sebagai Pencegah Hiperkolesterolemia pada Tikus Putih
Abstrak: Mahoni’s bark has been thought as wood industrial waste, it’s potency as hypercholesterolemic prevention agent has not been reported. The aim of this study was to test the potency of mahoni’s bark extract as hypercholesterolemic prevention agent in rats. Thirty five male rats were divided into 5 groups (n=7) namely normal group (N) fed with standard rat chow, hypercholesterolemic group (HK) fed with cholesterol chow (1,5%) and PTU (0,5 mg/KgBW), lovastatin group (HK + lovastatin 0,2857 mg/KgBW), E1 group (HK+ mahoni’s water extract 4,2 mg/KgBW), and E2 group (HK + mahoni’s water extract 21mg/KgBW). Experiments were carried out for 8 consecutive weeks. The total blood cholesterol concentrations were analyzed every 2 weeks using enzymatic cholesterol oxidase methode CHOD-PAP and measured by spectrophotometer at =500 nm. The results showed that administration of cholesterol chow (0,86%) and PTU (0,5 mg/KgBW) for 8 weeks in HK group increased cholesterol concentration 52,57%. Although the data statistically was not significant ( = 0.05), there is a tendency that mahoni’s extract at the dose E2 cause 35,8% reduction of cholesterol concentration and this was comparable to the reduction in the lovastatin group (33,78%).
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Judul: Peroksidasi Lipid pada Tikus Hiperkolesterolemia selama Pemberian Ekstrak Kulit Batang Mahoni (Swietenia macrophylla)
Abstrak: Mahogany’s bark is known as wood industrial waste that contains potential secondary metabolites. However, its potency as an antioxidant, especially in rats which are subjected to hypercholesterolemic treatment, has not been carried out. The aim of this study was to test the effect of mahogany’s water extract consumption on the concentration of lipid peroxides in hypercholesterolemic rats. Thirty five male rats were divided into 5 groups (n=7) namely normal group fed with standard rat chow, hypercholesterolemic group (HK) fed with cholesterol chow (1,5%) and PTU (0,5 mg/KgBW), lovastatin group (HK+lovastatin 0,2857 mg/KgBW), E1 group (HK+ mahogany’s extract 4,2 mg/KgBW), and E2 group (HK+mahogany’s extract 21 mg/KgBW). Experiments were carried out for 8 consecutive weeks. The concentration of lipid peroxides in blood were measured with thiobarbituric acid assay at week 0, 2, 4, 6, and 8 using spectrophotometer. Cholesterol chow (0.86%) and PTU increased the lipid peroxides concentration of HK group by 20.92% compared to the normal group (3.380±0.436 nmol/mL). However, it is not statistically significant (p=0.239). The lipid peroxides concentration in E1 and E2 weren’t increased and relatively similar to normal group at concentration of 2.353±0.196 nmol/mL, 2.786±0.256 nmol/mL, and 2.673±0.279 nmol/mL, respectively. Although it is not statistically significant, both doses of extracts tend to prevent the lipid peroxidation in the rat’s blood.
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Judul: Gelombang soliter internal pada lapisan atmosfiri yang memiliki perubahan kecepatan angin yang cepat
Abstrak: Gelombang internal adalah suatu gelombang yang terjadi di dalam suatu fluida. Gelombang ini muncul karena adanya perubahan rapat massa di setiap lapisan di dalam fluida. Salah satu gelombang internal yang ditemui di lappisan atmosfir adalah gelombang soliter internal, seperti yang terjadi pada fenomena "morning glory" di Australia. pada fenomena "Morning glory" terjadi penurunan tekanan hingga bebrapa milibar.
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