Judul: Efek Penghambatan Tumorigenesis Kelenjar Mammari Yang Diinduksi N-Metil-N-Nitrosourea Oleh Ekstrak Etanol Rimpang Temu Putih (Curcuma zedoaria (Berg.) Roscoe) Secara Makroskopis Pada Kelinci
Abstrak: Penelitian ini bertujuan untuk mengetahui efek penghambatan pembentukan tumor (tumorigenesis) pada kelenjar mammari yang diinduksi dengan n-metil-nnitrosourea (MNU) oleh ekstrak etanol rimpang temu putih (Curcuma zedoaria (Berg.) Roscoe). Sebanyak 9 ekor kelinci betina dengan umur 6-9 bulan digunakan dalam penelitian ini. Kelinci didistribusikan ke dalam 3 kelompok, yaitu kontrol positif tumor, perlakuan dengan curcumin dan perlakuan dengan pemberian ekstrak etanol rimpang temu putih. N-metil-n-nitrosourea digunakan sebagai induksan tumor dengan dosis 50 pgrkg berat badan intra mammari. Ekstrak etanol rimpang temu putih diberikan pada kelinci dengan dosis 250 mgkg berat badan, sedangkan curcumin diberikan dengan dosis 60 mgkg berat badan. Pembentukan tumor diamati secara makroskopis, dengan mengukur diameter tumor kelenjar mammari. Hasil pengamatan memperlihatkan bahwa terjadi penghambatan tumorigenesis pada kelompok yang diberi ekstrak etanol rimpang temu putih. Berdasarkan semua hasil temuan ini disimpulkan bahwa ekstrak etanol temu putih memiliki aktifitas dalam menghambat tumorigenesis.
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Judul: Kajian Mikroskopis Induksi N-Methyl-N-Nitrosourea Pada Kelenjar Mammari Kelinci
Abstrak: The aim of this research is to study the N-Methyl-N-Nitrosourea (MNU) induction on the rabbit’s mammary gland tumour formation. Six 6-9 month old, female rabbit were induced by N-Methyl-N-Nitrosourea (MNU) intramammary dose 50 μg/kg Body Weight, every 1 weeks for 4 week. After 4 weeks of induction, mastectomy were done. The mammary glands were processed for histopathological examination stained with HE. One lactating rabbit was act as normal mammary control. The result showed that the N-Methyl-N-Nitrosourea (MNU) could induced tumorigenesis which characterized as benign and slow growth tumor, as well as the inflammatory reaction.
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Judul: Sistem Informasi Geografis untuk Pola Aktivitas Manusia dengan Pemodelan Data Spatio-Temporal
Abstrak: The human activity in a given time period will shape its pattern. This research develops a spatiotemporal data model to support the prediction of human existence based on activity-pattern and also visualizes the activity locations in a GIS environment. This so-called mobility oriented spatiotemporal data model conceptualizes the spatial and temporal interaction of activity behaviour using the concept of mobility. In other words, activity patterns are conceptualized as a sequence of staying at or traveling between activity locations. The model can support the analysis and queries of activities from different perspectives, i.e. queries can be time-oriented, person-oriented, activity-oriented, and location-oriented. A prototype system based on the activity data modelling is implemented in MySQL 5.0.27 as DBMS with using PhpMyAdmin 2.9.1.1 software. Spatial database is developed with using software QuantumGIS and ArcView. The system could be accessed online through a web browser with MySQL as its database storage and Pmapper framework as the tools used in visualizing the activity locations.The information were provided in the form of activity attribute-data as the user requested and graphical-data (map) which contains information about its activity locations.
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