Judul: IPB (Bogor Agricultural University)
Abstrak: Non Steroid Anti Inflammatory Drugs / Aspirin is a drug which is currently widely used in the treatment of cases in the field of Rheumatology, Cardiology, Neurology, Hematology and Oncology. The expansion of clinical indications will result in the increasing prevalence of drug side effects, especially on the stomach. The initial clinical symptoms due to side effects of this drug are dyspepsia syndrome. If these symptoms are not quickly resolved more severe complications will happen in the form of upper gastrointestinal bleeding. The purpose of this study is to determine the changes in gastric pathology and histopathology due to side effects of aspirin. The study was conducted on 20 white rats Spague-Dawley strain which has been prepared starting from pre-study to eliminate bias factors that may affect the results of this study. Furthermore, rats were divided into 2 groups: the control and treatment groups The treatment group were given aspirin powder dissolved in water a dose of 400 mg once daily for 3 days, whereas the control group were given aquabidet. Afterthat necropsy was performed and the stomach was observed in macroscopic and microscopic examination to determine changes in cell activity such as mucus cells, inflammatory cells, parietal cells and chief cells as a component for defensive and agressive factors. Activities of isoenzyme cyclooxygenase 1 and cyclooxygenase 2 which associated with the production prostaglandin were examined by immunohistochemical staining. The results obtain from this study is gastric dilatation and mucus is a component of defensive factor can serve as primary and secondary prevention of gastric mucosal lesions. Inflammatory cells, gastric acid and pepsin are only contributor factors in the occurrence of mucosal lesions. Isoenzymes COX-1 and COX-2 is associated with the production of prostglandin, function of COX-1 as constitutive factor can be seen clearly, whereas COX-2 functions as an inflammatory factor does not provide a clear picture. Macroscopic and microscopic changes of the stomach will be used as a model in humans in conducting primary and secondary prevention of acute gastric mucosal lesions due to side effects of aspirin
Keyword: gastric dilatation, mucus, COX-1, C0X-2, sel parietal, sel chief, cyclooxygenase

Judul: IPB (Bogor Agricultural University)
Abstrak: Tujuan penelitian ini adalah mengevaluasi aktivitas antiproliferasi sel lestari tumor dan fagositosis secara in-vitro dari fraksi bioaktif yang diisolasi dari rimpang temu putih (Curcuma zedoaria ). Serbuk rimpang temu putih diekstraksi dengan pelarut organik (n-heksana, metanol dan etil asetat). Lima fraksi (A-E) dari ekstrak etil asetat diperoleh dengan teknik kromatografi menggunakan SiO 2 gel 60 dan fase gerak nheksana/ etil asetat (0-100%). Fraksi bioaktif (B dan C) dimurnikan dengan kromatografi cair kinerja tinggi (KCKT) dan diperoleh 1 fraksi (B-1) dari fraksi B dan 3 fraksi (C-1,C-2 dan C-3) dari fraksi C. Karakterisasi kimia dilakukan pada fraksi B-1 dan C-1 meliputi spektroskopi UV-Vis, infra merah dan massa. Pengujian bioaktivitas yang dilakukan adalah uji toksisitas terhadap larva udang (Artemia salina), uji antiproliferasi terhadap sel lestari tumor (sel HeLa, K-562, WEHI 164), aktivitas fagositosis terhadap Staphyllococcus epidermidis, analisis jumlah kromosom sel tumor dan perubahan morfologi dari sel lestari tumor.
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Judul: Algoritme LLL dan Aplikasinya dalam Pembongkaran Sistemkripto Knapsack Merkle-Hellman
Abstrak: LLL algorithm is an algorithm that can be used to determine an approximation of the shortest vector in a lattice. Size reduction algorithm is an important step of LLL algorithm. The LLL algorithm can be applied in many elds. This paper shows how LLL algorithm can be used in breaking one of the famous cryptosystem, namely the Merkle-Hellman knapsack cryptosystem. Merkle-Hellman knapsack cryptosystem is an asymmetric cryptosystem using the subset sum problem as the support of security. Subset sum problem can be transformed into the problem of determining shortest vector in a lattice, so that LLL algorithm can also be used to solve the subset sum problem. Since the subset sum problem can be easily solved by applying LLL algorithm, then the Merkle-Hellman knapsack cryptosystem can also be easily be destructed.
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