Judul: Pengaruh Pemberian Salep Fraksi Etil Asetat Rimpang Kunyit (Curcuma longa Linn.) terhadap Persembuhan Luka Mencit (Mus musculus albinus) Hiperglikemik
Abstrak: The aim of this research was to know the effect of turmeric (Curcuma linga Linn.) etil asetat fraction ointment in wound healing of hiperglicemic mice (Mus musculus albinus). Thirty mice were infected with 40 mg/kgbw of streptozotocin to induced hiperglicemic. Mice were divided into three groups, which were negative control without treatment, positive control was treated with the comersil ointment and the group with the etil asetat turmeric rhizomes fraction ointment treatment. Mice were wounded by scalpel blade on the their dorsoanterior skin of mice around 1.5 cm. The pathology-anatomy of the wound healing procces were observed everyday with wound size, wound colour, wound exudation, and scab formation as the parameter. The histopathology lesion were observed on the 2nd, 4th, 7th, 14th, and 21th days after skin incision. The parameter on the histopathology observation are number of polymorfonuclear cell (neutrofil), macrophag, neovascullary formation, the precentation of wound reepitelization and the percentation of collagen connective tissue. The histopathology observation of etil asetat turmeric rhizomes fraction ointment had anti inflamantory activity as well as neovascularization and reepithelization were faster than the other groups.
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Judul: Pengaruh Pemberian Salep Fraksi Heksan Rimpang Kunyit terhadap Persembuhan Luka Mencit Hiperglikemik
Abstrak: The aim of this research was to determine the potential and efficacy of hexane fraction of turmeric ointment on skin wound healing process of hyperglicemic mice based on gross lesion and histopathology observation. Thirty female mice ± 2 months old with body weight ± 20-25 g were used as experimental animals. Streptozotosin were induced at mice with dose of 40 mg/kg body weight intraperitoneally and were waited 1-2 weeks until blood sugar rate rised up to 200 mg/dl. Mice were wounded by scalpel blade on back area around 1.5 cm. Mice were divided into three groups, which were negative control, positive control, and a group treated with hexane fraction of turmeric ointment. The follow-up times was taken every 2nd, 4th, 7th, 14th, and 21st days. Each follow-up, two mice from each treatment group get euthanased and then were measured to length change observations cuts and wounds of anatomic pathology (PA) and skin samples were taken for histopathology preparations. PA observations showed that wound healing process in the treated with hexane fraction of turmeric ointment was faster than other treatment groups. Histopathology showed that hexane fraction of turmeric ointment could reduce inflammation process (antiinflammatory), reephitelisation and collagen tissue in hyperglycemic mice. It can be concluded that hexane fraction of turmeric ointment might accelerate wound healing process in hyperglicemic mice.
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Judul: Construction of Strongly Optimal Binary Linear Code with Minimum Distance 9 and 11
Abstrak: A binary linear code of length n over q F is a subspace of n q F . A code has three parameters that attached to it, namely length, dimension, and minimum distance. A code with length n, dimension k and minimum distance d is often called [n, k, d ]-code. Usually, when two parameters are given, then we want to find a code that has the best value for the last parameter. Based on Gilbert- Varshamov bound, if a [n, k, d ]-code exists and can not be expanded, we call it a strongly optimal code. In this paper, we construct strongly optimal code with minimum distance 9 and 11. In constructing the code, we created a theorem and algorithm based on Gilbert-Varshamov bound before we implement the algorithm to MAPLE programming language. Because of computational limitations, the program can only construct up to k = 10 for d = 9 and k = 12 for d = 11.
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