Judul: Toksisitas Ekstrak Etanol Temu Lawak (Curcuma xanthorriza Roxb) Berdasarkan Uji Letalitas Larva Udang dan Embrio Ikan Zebra
Abstrak: Temu lawak (Curcuma xanthorriza) telah diketahui memiliki berbagai aktivitas farmakologis dengan kurkuminoid adalah senyawa aktif yang dominan. Penelitian ini bertujuan menentukan kadar kurkuminoid dan menguji toksisitas ekstrak etanol dan fraksi etil asetat temu lawak. Kadar kurkuminoid ditentukan menggunakan kromatografi cair kinerja tinggi, sedangkan uji toksisitas menggunakan larva udang (metode BSLT) dan embrio ikan zebra (metode ZFET). Berdasarkan hasil penelitian, kadar kurkuminoid ekstrak etanol lebih tinggi daripada fraksi etil asetat, yaitu 105 mg/g. Hasil uji toksisitas menunjukkan nilai konsentrasi mematikan 50% (LC50) pada metode ZFET lebih kecil daripada metode BSLT. Pada metode BSLT, nilai LC50 ekstrak etanol adalah 238 ppm dan fraksi etil asetat 177 ppm, sedangkan pada metode ZFET, nilai LC50 96 jam pascafertilisasi ekstrak etanol adalah 80 ppm dan fraksi etil asetat 94 ppm. Ekstrak etanol menyebabkan malformasi mayor pada jantung, sedangkan pemberian fraksi etil asetat menyebabkan malformasi mayor pada sumbu tubuh dan jantung embrio ikan zebra.
Keyword: BSLT, LC50, temu lawak, toksisitas, ZFET

Judul: Uji Toksisitas Ekstrak Etanol Rimpang Temu Putih terhadap Larva Udang dan Embrio Ikan Zebra
Abstrak: Curcuma zedoaria, known as temu putih, is commonly used as traditional medicine in Indonesia. The toxicity of this herb needs to be studied to improve its application. This research aims to evaluate the toxicity of the crude ethanol extract of temu putih rhizome against brine shrimp (Artemia salina) larvae and zebrafish (Danio rerio) embryos and to analyze the suspected active compounds contained in the extract. The crude ethanol extract showed 50% lethal concentration value (LC50) at 588 ppm against brine shrimp larvae and 215 ppm against zebrafish embryos. In zebrafish embryos, exposure of the crude ethanol extract has caused major malformation in development of head, namely brain and eyes organs. Based on the gas chromatography-mass spectrometry analysis, the suspected active compound that play a role in the toxicity are epicurzerenone, curzerene, and curzerenone, which 2,4,6-trimethylacetophenone as the predominant compound.
Keyword: Bogor Agricultural University (IPB), LC50, Danio rerio, Curcuma zedoaria, Artemia salina

Judul: Implementation of Spatio-Temporal Change Query in Relational Database.
Abstrak: Geographic object changes in various views. Object changes are recorded using a model of static storage. No historical connection between old version data and new version data has been built. For that, a storage model of spatio-temporal queries that can analyze spatio-temporal changes has been developed. The object changes the geometry are grouped according to the taxonomy of Spatio-Temporal Pattern Change. This research has been able to apply the query patterns change including born, expand, merge, contract, split, normal and die. This query based on geometric (area) changes. The implementation of spatio-temporal change queries represents an object changes continuously with easy, change detection is done by comparing two versions of data. Keyword: spatio-temporal change query, spatio-temporal change pattern.
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