Judul: Desain Pengembangan Ekowisata mangrove Istambul Demak, Jawa Tengah
Abstrak: Kabupaten Demak merupakan daerah pesisir di pantai utara Jawa Tengah yang memiliki potensi ekosistem mangrove yang masih alami. Ekosistem mangrove di Kabupaten Demak dapat dikembangkan untuk kegiatan ekowisata adalah ekosistem mangrove Istambul Demak, terletak di desa Tambakbulusan, Kecamatan Karang Tengah. Tujuan dari penelitian ini adalah untuk mengembangkan ekowisata mangrove melalui analisis kesesuaian ekowisata mangrove sebagai destinasi ekowisata, menghitung daya dukung kegiatan ekowisata, serta membuat strategi dan desain kegiatan ekowisata mangrove Istambul Demak. Hasil menunjukkan bahwa ekosistem mangrove Istambul sesuai untuk dijadikan sebagai kawasan ekowisata. Aktifitas ekowisata yang dapat dikembangkan di ekosistem tersebut yaitu tracking mangrove dengan daya dukung sebesar 122 orang perhari, berperahu dengan daya dukung sebesar 182 orang perhari, dan rekreasi pantai dengan daya dukung sebesar 40 orang perhari. Terdapat setidaknya 7 strategi yang dilakukan dalam pengembangan ekowisata mangrove Istambul.
Keyword: daya dukung, destinasi, kesesuaian wisata

Judul: Pengembangan Ekowisata di Mangrove Lindung Angke Kapuk. Jakarta Utara
Abstrak: Pengembangan ekowisata mangrove merupakan suatu cara untuk mendukung adanya konservasi lingkungan dan meningkatkan keikutsertaan masyarakat dalam mendukung kelestarian lingkungan agar mempertahankan keutuhan, keaslian, keunikan serta kelestarian suatu ekosistemnya. Penelitian ini bertujuan menganalisis kesesuaian ekosistem mangrove untuk ekowisata, menghitung daya dukung kawasan, dan merumuskan strategi pengembangan ekowisata Mangrove Lindung Angke Kapuk, Jakarta Utara. Metode penelitian yang digunakan, yaitu dengan survei/observasi lapangan. Pengambilan sampel kerapatan mangrove menggunakan metode petak contoh ganda yang dilakukan secara Purposive sampling yang mewakili. Beberapa fasilitas telah tersedia dan dapat dikembangkan untuk kegiatan seperti tracking mangrove, area duduk santai, dan memancing. Strategi pengelolaan kawasan ekowisata Mangrove Lindung Angke termasuk dalam kategori cukup baik, sehingga perlu dimaksimalkan strategi pengembangan ekowisata dengan memprioritaskan tiga alternatif strategi utama., The development of mangrove ecotourism is a way to support environmental conservation and increase community participation in supporting environmental sustainability in order to maintain the integrity, authenticity, uniqueness and sustainability of an ecosystem. This study aims to analyze the suitability of mangrove ecosystems for ecotourism, calculate the carrying capacity of the area, and formulate a strategy for developing ecotourism in the Mangrove Protected Angke Kapuk Ecotourism, North Jakarta. The research method used is survey/field observation. Mangrove density sampling was taken using a multiple sample plot method which was carried out by representative purposive sampling. Several facilities are available and can be developed for activities such as mangrove tracking, relaxing sitting areas, and fishing. The strategy for managing the Angke Protected Mangrove ecotourism area is in the fairly good category, so it is necessary to maximize the ecotourism development strategy by prioritizing three main strategic alternatives.
Keyword: area carrying capacity, development strategy, ecotourism mangroves

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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