Judul: Inhibisi Siklooksigenase-2 Ekstrak Legetan Warak (Adenostemma lavenia) dan Kenikir (Cosmos caudatus) sebagai Antiinflamasi
Abstrak: Penyakit paru obstruktif kronik (PPOK) adalah peradangan kronis yang menghalangi aliran udara dari paru-paru. Inflamasi paru-paru merupakan respons normal pada pasien PPOK yang biasanya dapat ditangani dengan obat antiinflamasi. Obat antiinflamasi, sintetik atau alami, berfungsi sebagai inhibitor enzim siklooksigenase-2 (COX-2). Penelitian ini bertujuan menentukan kandungan metabolit sekunder secara kualitatif, potensi bioaktivitas, dan daya inhibisi ekstrak legetan warak (Adenostemma lavenia) dan kenikir (Cosmos caudatus) terhadap aktivitas enzim COX-2 sebagai antiinflamasi untuk pengembangan obat PPOK. Sampel dimaserasi dalam pelarut etanol 70% dan air. Uji fitokimia menyatakan bahwa kedua jenis sampel mengandung metabolit sekunder golongan flavonoid. Ekstrak etanol herba legetan warak, ekstrak etanol dan ekstrak air kenikir menunjukkan potensi bioaktivitas dengan nilai LC50 < 1000 μg/mL. Ekstrak air kenikir konsentrasi 50 μg/mL memberikan daya inhibisi tertinggi terhadap aktivitas COX-2 dibandingkan dengan ekstrak lainnya, tetapi masih < 50%. Fakta ini memperlihatkan bahwa ekstrak kedua tumbuhan tersebut tidak berpotensi sebagai antiinflamasi untuk dikembangkan sebagai obat PPOK.
Keyword: antiinflamasi, COX-2, kenikir, legetan warak, PPOK

Judul: Potensi Ekstrak Legetan Warak (Adenostemma lavenia) dan Daun Kersen (Muntingia calabura) sebagai Kandidat Obat PPOK
Abstrak: Inflamasi paru-paru merupakan respons normal pada pasien penyakit paru obstruktif kronik (PPOK) yang biasanya dapat ditangani dengan obat antiinflamasi. Sebagian besar obat anti inflamasi bekerja menghambat aktivitas siklooksigenase yang memproduksi mediator inflamasi. Penelitian ini bertujuan mengkaji potensi antiinflamasi ekstrak legetan warak (Adenostemma lavenia) dan daun kersen (Muntingia calabura) guna pengobatan PPOK melalui daya hambat terhadap enzim siklooksigenase-2 (COX-2) serta menduga senyawa kimia yang berperan di dalamnya melalui uji laboratorium dan studi pustaka. Uji fitokimia menunjukkan bahwa kedua spesies mengandung senyawa flavonoid. Kesimpulan yang dapat diambil dari studi literatur yang telah dilakukan yaitu ekstrak legetan warak dan daun kersen berpotensi sebagai antiinflamasi dengan menghambat aktivitas COX-2. Senyawa yang diduga berperan sebagai COX-2 inhibitor adalah senyawa dari golongan flavonoid dan fenolik.
Keyword: antiinflamasi, COX-2, kersen, legetan warak, PPOK

Judul: Thermal Characteristics and Dynamics of Tropical Cyclone over Western North Pacific Ocean: A Case Study of Typhoon Songda (Chedeng) 2011
Abstrak: The frequent occasion of Tropical Cyclone (TC) over Western North Pacific (WNP) Ocean lies from 10˚N to 26˚N and 121˚E to 170˚E. Sources of TC development come from warm ocean temperature where latent heat is released during condensation processes and subsequently concentrated in the boundary layer. Relative humidity at 850-700 hPa is responsible to produce the most intense storm. Meanwhile, weak vertical wind shear between 850-200 hPa is one of the dynamical factors that lead to the development of TC. Pressure level of 850-200 hPa is chosen to minimize the thermodynamic effect in the lower troposphere. Typhoon Songda (Chedeng in the Philippines) or TSC lasted from May 18th to 30th, 2011 and strengthened into powerful Super Typhoon stage between May 24th and 27th. Long curving track and the exhibition of all sequences of TC life cycle, TSC is then considered as an ideal case of TC. The objective of the study with case of TSC is to investigate the role of thermal characteristics and dynamics on TC intensity. The research is carried out by using Advanced Research of Weather Research and Forecasting model (WRF ARW model) version 3.3. Two domains are employed in the model. The first domain situate from 02˚N to 40˚N and 118˚E to 149˚E and cover spatial resolution () of 33.1 km. The second domain situate from 09˚N to 27˚N and 119˚E to 132˚E with of 11 km. Timestep of the model () is 120 seconds. The model is supported by the following physical parameterization, i.e., Yonsei University Scheme (YSU) in the boundary layer, Kain-Fritsch scheme (KF) in the cumulus, and WRF Single-Moment 3-class scheme in the microphysics. Initial meteorological condition prior to the formation of the cyclone is generated using WRF ARW standard-release model. Sensitivity of the model output is obtained from a selected single-parameter change scenarios, namely, 10 % to 20 % decrease and increase of wind shear initial data at 850-200 hPa, and by 10 % to 20 % decrease of relative humidity initial data at 850-700 hPa. The result showed that the negative correlations between wind shear and intensity are found in wind shear scenarios. Wind shears of 10 ms-1 which lead to strengthening of the wind intensity in the early period of Typhoon development are found in wind shear scenarios. The effect of wind shear changes on wind intensity is statistically significant in the 20 % wind shear scenarios. During mature stage, weak wind intensity occurred when wind shear increase as given in the WRF standard-release and the 20 % decreasing scenario. Different situation is found in the 20 % increasing scenario where wind shear tend to weak and lead to strong wind intensity at this stage. Meanwhile, the reduction of moisture supply at 850-700 hPa resulting from 20 % decreasing relative humidity play a major role in the weakening of wind intensity and reduces mechanical energy of the cycle process as much as 300 J kg-1.
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