Judul: Sistem penunjang keputusan pengembangan agroindustri komoditas pertanian di kawasan agropolitan (Studi kasus di kecamatan Pangalengan dan Kertasari, Kabupaten Bandung, Jawa Barat)
Abstrak: Pembangunan pertanian merupakan bagian terpenting yang tidak dapat dipisahkan dari pembangunan ekonomi dan pembangunan nasional yaitu stabilitas nasional yang mantap, pertumbuhan ekonomi yang tinggi dan pemerataan pembangunan serta hasil-hasilnya. Keberhasilan pembangunan pertanian terutama pada hal peningkatan hasil produksi akan memacu dan mempercepat informasi struktur perekonomian suatu daerah. Pendekatan pembangunan yang mengedepankan pertumbuhan ekonomi secara cepat telah mengakibatkan pertumbuhan di perkotaan melampaui kawasan lainnya atau mendorong percepatan urbanisasi (purcluated urbanization). Hal ini menimbulkan dampak negatif yakni terserapnya sumberdaya yang dimiliki pedesaan oleh kawasan perkotaan, baik sumberdaya alam maupun sumberdaya manusia. Dana pembangunan tidak dapat termanfaatkan secara efektif dan efisien guna mendorong peningkatan pendapatan daerah tersebut.
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Judul: Sistem Penunjang Keputusan Pengembangan Agroindustri Komoditas Pertanian di Kawasan Agropolitan (Studi Kasus di Kecamatan Pangalengan dan Kertasari, Kabupaten Bandung)
Abstrak: Agricultural development is an important part of integrated economic development to create national stability, high economic development and prosperity. Successfull increasing production of agriculture stimulate and transform economicall structure in the area. Development approach based on high rate of economic growt was caused development urban area left behind left the other areas and punctuated urbanization. This problem has a negative impact on absorption of rural resources by urban area, and development funding not effectively and efficiently increase the income of people in rural area. In the agropolitan project an economic development not onlu carried out in urban area. The economic development was focused at rural area in order to create a centre of agricultural development activities i.e. : cultural practices, post harvest processing, marketing and distribution for consumer in rural area. In the feasibility for agricultural farming - agroindustry in Kertasari and Pangalengan was analyzed with Net Presesnt Value (NPV), Pay Back Period (PBP) and B/C Ratio. The result from sub model for financial feasibility analysis shows that for 10 year projects, the pasteurization fresh milk industry is feasibility to implement,since it predicts to have total net profit for Rp 445.374.872, PBP for 3,51 years and B/C Ratio for 2,02. Even though the raw materials raise for 20% or the selling prices falls for 6%, the analysis shows that the pasteurization of milk industry is still feasible to implement. BUt if the raw material raise for 21% for the selling prices falls for 7%, the analysis shows that the pasteurization of milk industry is not feasible to implement. This mean that the selling price falls is more sensitive than if the raw material raise
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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