Judul: Uji in vitro ekstrak air dan etanol dari buah asam gelugur, pimpang Lengkuas, dan kencur sebagai inhibitor aktivitas lipase pankreas
Abstrak: Buah asam gelugur merupakan marga Garcinia, sering digunakan sebagai obat penurun bobot badan. Lengkuas dan kencur adalah tanaman obat tradisional yang berpotensi sebagai antiobesitas yang mudah didapat dan murah karena telah diteliti mampu menurunkan fosfolipid, trigliserida, serta kolesterol. Penelitian ini bertujuan mengevaluasi potensi ketiga tanaman sebagai antiobesitas melalui kemampuan ekstrak air dan etanolnya dalam menghambat aktivitas lipase pankreas secara in vitro pada pH 8,0, waktu inkubasi 45 menit, dan suhu 40°C. Penelitian ini menggunakan lipase pankreas manusia (1,4 × 10-5 μg/μL) dan minyak wijen (16,2 μg/μL) sebagai substrat. Ekstrak air dan etanol buah asam gelugur secara berurutan mengandung saponin dan alkaloid. Ekstrak lengkuas mengandung alkaloid, flavonoid, saponin, dan kuinon, sedangkan ekstrak etanolnya mengandung alkaloid, flavonoid, saponin, dan steroid. Ekstrak air kencur mengandung saponin dan kuinon, sedangkan ekstrak etanolnya mengandung alkaloid, flavonoid, steroid, dan kuinon. Ketiga tanaman berpotensi sebagai antiobesitas karena berdasarkan hasil uji in vitro mampu menginhibisi aktivitas lipase pankreas. Daya inhibisi tertinggi dari semua ekstrak dicapai oleh ekstrak etanol buah asam gelugur dengan nilai 86,3% pada konsentrasi 150 ppm. Daya inhibisi tertinggi lengkuas dicapai oleh ekstrak etanolnya pada konsentrasi 200 ppm, yaitu sebesar 56,2%. Daya inhibisi tertinggi ekstrak kencur dicapai oleh ekstrak etanolnya dengan nilai 37,6% pada konsentrasi 300 ppm. Nilai-nilai tersebut lebih besar jika dibandingkan dengan kontrol positif (Xenical®) pada 100 ppm, yaitu sebesar 10,6%.
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Judul: In Vitro Assay of Water and Ethanol Extracts of Asam Gelugur Fruits, Lengkuas, and Kencur Rhizomes as Inhibitor of Pancreatic Lipase Activity.
Abstrak: Asam gelugur fruits of Garcinia oftenly used to reduce body weight. Lengkuas and kencur are traditional herbal that potential as inexpensive and available antiobesity because they had been studied could reduce the level of phospholipids, triglycerides, and cholesterol. This research evaluated the potencies of these herbal as antiobesity by their water and ethanol extracts capabilities in inhibiting pancreatic lipase activity in vitro at pH 8,0, incubation time 45 minutes, and temperature 40°C. This research used human pancreatic lipase (1,4 × 10-5 μg/μL) and sesame oil (16,2 μg/μL) as substrate. The water and ethanol extracts of asam gelugur fruits contained saponins and alkaliods, respectively. The water extract of lengkuas rhizomes contained alkaloids, flavonoids, saponins, dan quinones, while the ethanol extract contained alkaloids, flavonoids, saponins, and steroids. The water extract of kencur rhizomes contained saponins and quinones, while the ethanol extract contained alkaloids, flavonoids, steroids, and quinones. These plants have potencies as antiobesity based on in vitro assay in inhibiting pancreatic lipase activity. The highest inhibitory effect of all extracs was obtained from the ethanol extract of asam gelugur fruits with value of 86,3% at 150 ppm. The highest inhibitory effect of lengkuas extracts was from the ethanol extract at 200 ppm, which was about 56,2%. The highest inhibitory effect of kencur was showed by the ethanol extract with the value 37,6% at 300 ppm. These values were higher than the inhibitory effect of the positive control (Xenical®) at 100 ppm, about 10,6%.
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Judul: Implementation of Spatio-Temporal Change Query in Relational Database.
Abstrak: Geographic object changes in various views. Object changes are recorded using a model of static storage. No historical connection between old version data and new version data has been built. For that, a storage model of spatio-temporal queries that can analyze spatio-temporal changes has been developed. The object changes the geometry are grouped according to the taxonomy of Spatio-Temporal Pattern Change. This research has been able to apply the query patterns change including born, expand, merge, contract, split, normal and die. This query based on geometric (area) changes. The implementation of spatio-temporal change queries represents an object changes continuously with easy, change detection is done by comparing two versions of data. Keyword: spatio-temporal change query, spatio-temporal change pattern.
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