Judul: Aktivitas Antioksidan Ekstrak Biji Mahoni (Swietenia mahagoni Jacq.) sebagai Kandidat Obat Antidiabetes
Abstrak: Diabetes mellitus (DM) is a progressive chronic degenerative disease with glucose, protein, and lipid metabolic dysfunction. DM is one of oxidative stress conditions that requiring additional exogenous antioxidants. Mahagony is potential for antioxidant which can be used as an antidiabetic medicine. The objective of this research is to compare antioxidant activity of several Swietenia mahagony seed extracts from different methods of extraction (reflux and maceration) and type of solvents (ethanol and water). Antioxidant activity of all extract were evaluated by DPPH method and quantified the IC50 values. The IC50 values of all extracts are 1.03 mg/ml, 1.87 mg/ml, 4.09 mg/ml, and 1.15 mg/ml, respectively to ethanol maceration extract (ME), water maceration extract (MA), ethanol reflux extract (RE), and water reflux extract (RA). The result showed that extract resulted from maceration method using ethanol has the highest antioxidant activity, compare to the others (MA, RE, and RA).
Keyword: Swietenia mahagoni Jacq, reflux, maceration, DPPH, antioxidant, Bogor Agricultural University (IPB)

Judul: Aktivitas Antioksidan Ekstrak Etanol Biji Mahoni (Swietenia mahagoni Jacq.) pada jaringan Hati dan Ginjal Tikus Model Diabetes: Studi Imunohistokimia
Abstrak: Diabetes mellitus (DM) is a syndrome metabolic disease that can be indicated with high of blood glucose levels. The decreasing of carbohydrate metabolism, protein, and lipid in DM caused by deficiency and resistance of insulin. The DM condition has increased production of free radical and reactive oxygen spesies (ROS) that create a situation of known as oxidative stress, which antioxidant is lower than the amount of free radicals. As an alternative to handle oxidative stress condition, the patients of DM can consume high antioxidant plant to prevent the complication of the disease due to diabetes and to help lower of blood sugar. Any one of plant which has the antioxidant is the mahogany seeds (Swietenia mahagoni Jacq.). The mahogany seeds were conducted from the Leuwiliang, Bogor Districts, West Java. The aim of this research were to: (1) analyze the antioxidant activity of an ethanol mahogany seeds extract, (2) measure the amount of feed consumption, body weight, and blood glucose levels of diabetic rats, (3) measure of malondialdehyde levels (MDA) of the liver and kidney tissues of diabetic rats, and (4) analyze the content of antioxidant Cu,Zn-SOD of the liver and kidney tissues of diabetic rats using immunohistochemical technique. The study was used male Rattus norvegicus strain Sprague Dawley. The rats were divided into 5 groups: (i) negative control group/ non DM (K-), (ii) positive control group/ DM (K+), (iii) DM group was treated with 500 mg/kgBW of the ethanol mahogany seeds extract (EM), (iv) DM group was treated with 2 mg/kgBW of acarbose (KO), and (v) non DM group was treated with 500 mg/kgBW of the ethanol mahogany seeds extract (KE). The condition of DM was obtained by alloxan (110 mg/kgBW) induction that injected by intraperitoneal. The the measurement of blood glucose levels was used glucometer two days after alloxan induced. The blood has taken with piercing the tip of tail rats using a frank needle. Furthermore, each group has given extract treatment once a day in the morning for 28 days. The treatment has given using sonde needle. The extracts was used an ethanol mahogany seed extract macerated with 96% ethanol solvent. The weight of feed consumption was conducted every day, while the measurement of blood glucose levels and body weight of rats was conducted every four days. The weight of feed number, body weight and measurement of blood glucose levels should be done every morning before the provision of extract treatment. At the end of the treatment, the rats were anesthetized with ketamine (75 mg/kgBW) and xylazine (8 mg/kgBW). The liver and kidney tissues were conducted and analyzed for (a) the content of malondialdehyde (MDA) using thiobarbiturate acid reactive substance (TBARS) method and (b) the content of antioxidant Cu,Zn-SOD using immunohistochemical technique. The results showed that an ethanol mahogany seeds extract that macerated with 96% ethanol solvent have a weak in antioxidant activity. The DM rats that has given an ethanol mahogany seeds extract (EM) have the similiar number of feeds consumption (P>0.05) with K- group. This condition was followed by the increasing of body weight on the EM group
Keyword: diabetic experimental rats, malondialdehyde, superoxide dismutase, Swietenia mahagoni Jacq

Judul: Instrumen elektronik berbasis akustik sebagai alat ukur pasang surut air laut
Abstrak: Pengukuran pasang-surut sangat diperlukan sehubungan dengan pemanfaatan data yang diperoleh oleh berbagai bidang ilmu, misalnya oseanografi, geologi, perikanan, clan lain-lain. Dengan memanfaatkan time delay dalam pengukuran jarak target dalam sistem akustik maka dirakitlah peranti elektronik kecil yang dapat mengukur jarak target dimana permukaan air sebagai obyeknya. Metode yang dipakai dalam penelitian ini meliputi beberapa tahap, yaitu tahap perakitan lEP, tahap uji coba di laboratorium clan tahap uji coba di lapang. Pada tahap perakitan lEP dilakukan pengumpulan komponen yang dilanjutkan dengan penyolderan pada Printed Circuit Bord. Pada tahap uji coba di laboratorium dilakukan simulasi pasut pada sebuah bak air berukuran 2 x 2 meter. Tahap yang terakhir adalah pengujian lEP pada keadaan yang sebenarnya dimana permukaan air laut dijadikan sebagai target yang diukur jaraknya ternadap lEP. Melalui hasil uji coba Instrumen Elektronik Pasut (lEP) di laboratorium, diperoleh data bahwa instrumen ini memiliki kisaran deviasi antara 0.40 sampai 0.54. Untuk uji coba di lapang diketahui melalui analisis error yang dilakukan bahwa 1EP memiliki sudut kemiringan garis regresi mendekati 45 derajat yaitu sebesar 45.98 derajat
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