Judul: Activity of breast anticancer of active compound from Spatholobus suberectus stem’s by in silico
Abstrak: Sekitar lebih 70% kasus kanker payudara adalah tipe positif hormon reseptor. Kasus kanker payudara tipe ini lebih banyak terjadi pada wanita post menopaus. Pengobatan yang efektif kasus ini adalah pemberian inhibitor enzim aromatase. Senyawa isoflavonoid batang Spatholobus suberectus telah teruji secara in vitro memiliki aktivitas sitotoksik terhadap sel kanker payudara MCF-7 yang banyak mengekspresikan reseptor estrogen dan enzim aromatase. Perlu dilakukan pencarian senyawa lain batang Spatholobus suberectus yang berpotensi memiliki aktivitas antikanker payudara. Penelitian ini bertujuan memprediksi potensi senyawa-aktif batang Spatholobus suberectus sebagai antikanker payudara melalui mekanisme penghambatan enzim aromatase secara in silico dengan metode penambatan molekular. Simulasi penambatan molekuler dilakukan melalui parameter energi ikat (ΔG), konstanta inhibisi (Ki), jenis interaksi dan binding site similarity (BSS). Senyawa aktif yang diprediksi memiliki potensi adalah prestegane B, 2R,3R-3,7-dihidroksiflavanon, dihidrorobinetin, asam protokatekuat etil ester, liquiritigenin, naringenin, 7,4’-dihidroksi-8-metoksi-isoflavone, asam protokatekuat, glisirosida, dulcisflavan, butein, hesperetin, plathymenin, isoliquiritigenin, dan medioresinol., Approximately over 70% of breast cancer cases are positive types of hormone receptors. Cases of this type of breast cancer are more common in post menopausal woman. An effective treatment of this case is the administration of aromatase enzyme inhibitors. The stem isoflavonoid compound Spatholobus suberectus has been tested in vitro has cytotoxic activity against MCF-7 breast cancer cells that expressed a lot of estrogen receptors and aromatase enzymes. It is necessary to search for other compounds of Spatholobus suberectus stem that have the potential to have anticancer activity of the breast. This study aimed to predict the potential of compound-active stem Spatholobus suberectus as an anticancer breast through the mechanism of inhibition of aromatase enzymes in silico by molecular docking method. Molecular tethering simulation is done through binding energy parameters (ΔG), inhibition constants (Ki), types of interaction and binding site similarity (BSS). Active compounds that was predicted to have potential are prestegane B, 2R,3R-3,7-dihydroxyflavanon, dihydrorobinetin, protocatechuic acid ethyl ester, liquiritigenin, naringenin, 7,4’-dihidroksi-8-metoksi-isoflavone, protocatechuic acid, glyciroside, dulcisflavan, butein, hesperetin, plathymenin, isoliquiritigenin, and medioresinol.
Keyword: molecular docking, inhibitor, aromatase

Judul: Identification of Active Compounds in Endophytic Fungi Isolated From Soursop Leaf and Its Potential as Selective Estrogen Receptor Modulators
Abstrak: Kapang endofit daun sirsak memiliki aktivitas antikanker payudara dengan menghambat pertumbuhan sel kanker MCF-7. Sel ini mengekspresikan reseptor estrogen khususnya reseptor estrogen α. Penelitian ini bertujuan mengidentifikasi komponen senyawa aktif kapang endofit daun sirsak dan menentukan potensinya sebagai antikanker payudara melalui penghambatan reseptor estrogen α. Metode penelitian meliputi ekstraksi kapang endofit, identifikasi senyawa aktif dengan LC-MS/MS, dan studi in silico menggunakan reseptor estrogen α. Terdapat 44 senyawa yang berhasil teridentifikasi dengan waktu retensi yang beragam dan sebanyak 15 senyawa berpotensi sebagai antikanker payudara karena kemampuannya dalam menghambat pertumbuhan dan memicu terjadinya apoptosis pada sel kanker. Studi in silico menunjukkan senyawa 3-[(4-hydroxyphenyl)methyl]-octahydropyrrolo[1,2-a]pyrazine-1,4-dione memiliki efek inhibisi terbaik dengan nilai ∆G sebesar -8.3 kkal/mol. Simpulan penelitian ini adanya kemampuan dari ekstrak kapang endofit daun sirsak dalam menghambat reseptor estrogen α, Endophytic fungi isolated from soursop leaves has anticancer activity due to its ability to inhibit the growth of MCF-7 cancer cells. This cell express estrogen receptor, especially estrogen receptor α. This study aimed to identify the active compound in endophytic fungi isolated from soursop leaf and determine the potential as an anticancer of breast cancer through estrogen receptor α inhibition. The method of the research included endophytic fungi extraction, identification of active compound using LC-MS/MS, and in silico study used estrogen receptor α. There are 44 active compounds that are successfully identified with various retention times and 15 compounds has potential as anticancer due to their ability to inhibit the growth and trigger apoptosis in cancer cells. In silico study showed that 3-[(4-hydroxyphenyl)methyl]-octahydropyrrolo[1,2-a]pyrazine-1,4-dione has the best inhibition with ∆G values is -8.3 kcal/mol . The conclusion of this study is the ability of the extract of endophytic fungi isolated from soursop leaf to inhibit estrogen receptors α.
Keyword: breast cancer, endophytic fungi, estrogen receptor, soursop leaves

Judul: Approximation of the Median of Poisson Distribution Using the Relation of Poisson-Gamma Distribution
Abstrak: A major drawback of median is that median cannot usually be defined in closed form, even in the cases where their distribution functions are known. This study gives an approximation of the closed form for the median of the Poisson distribution by using the relation of Poisson-Gamma distribution. The approximation uses elementary techniques based on the monotonicity of certain sequences involving tail probabilities of the Poisson distribution and the Central Limit Theorem. Furthermore, a closed form expression for the mean absolute deviation 􀜧|􀜰􀰒 􀵆 􀜯􀝁􀝀􁈺􀜰􀰒􁈻| is also studied. The median is relevant because of the fact that it minimizes the mean absolute deviation of a Poisson random variable (􀜰􀰒􁈻 by considering median as central tendency.
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