Judul: Fraksi aktif ekstrak daun sansevieria trifasciata lorentii sebagai penghambat proliferasi sel lestari HeLa
Abstrak: Daun lidah mertua (Sansevieria sp) telah banyak diteliti, terutama khasiatnya sebagai antioksidan dan antibakteri, sedangkan khasiat sebagai antikanker belum pernah dilaporkan. Oleh karena itu, tujuan penelitian ini adalah mengisolasi fraksi aktif ekstrak daun Sansevieria trifasciata yang dapat menghambat proliferasi sel lestari HeLa secara in vitro. Teknik ekstraksi dilakukan secara maserasi dalam metanol 96% dan dipekatkan menggunakan penguap putar. Ekstrak metanol difraksinasi menggunakan kolom kromatografi melalui proses elusi gradien dengan nisbah pelarut kloroform dan metanol. Uji fitokimia dan uji penghambatan proliferasi sel lestari HeLa dengan metode MTT [3-(4,5-dimetiltiazol-2-il)-2,5-difeniltetrazolium bromida] dilakukan terhadap ekstrak kasar dan hasil fraksinasi pada konsentrasi antara 10-100 ppm. Rendemen ekstrak kasar daun lidah mertua diperoleh sebesar 18% dan mengandung flavonoid, saponin, dan steroid. Nilai daya hambat proliferasi sel lestari HeLa tertinggi untuk ekstrak kasar diperoleh sebesar 23% pada konsentrasi 10 ppm. Hasil uji hambat yang teraktif dari sepuluh fraksi adalah 41% pada konsentrasi 100 ppm dan mengandung metabolit golongan steroid.
Keyword: HeLa cell line, Kromatografi kolom, Bogor Agricultural University

Judul: Fraksi aktif ekstrak daun Sansevieria trifasciata Prain sebagai penghambat pertumbuhan sel lestari HeLa
Abstrak: Sansevieria trifasciata Prain is an ornamental plant which is also useful as a source of antibacterial and antioxidant agent. Studies of S. trifasciata Prain as anticancer have not been reported. Therefore, the objective of this study is to isolate bioactive compounds of S. trifasciata Prain leaves that shows in vitro proliferation inhibition of HeLa cell lines. The sample was macerated in 96% methanol and concentrated using a rotary evaporator. The crude extract was fractionated using chromatography column with silica gel as the stationary phase and gradient chloroform-ethyl acetate as the mobile phase. Qualitative phytochemical and inhibition activity using MTT assay (3- (4,5-dimethylthiazol- 2-yl)-diphenyltetrazolium-2,5-bromide) were performed on the crude extract and its fractions at concentrations between 200 and 1000 ppm. The crude extract contained flavonoids, alkaloids, and steroids, but the crude extract could not inhibit proliferation of HeLa cell lines. The chromatography resulted 10 fractions, however, there was only one fraction with the highest proliferation inhibition was 87.52% at concentration of 10000 ppm that. This fraction contained flavonoids and alkaloids.
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Judul: The impact and contribution of the tourism sector to the Indonesian economy : an I-O and SAM approach
Abstrak: Tourism is an important and strategic sector for the Indonesian economy. The sector has been growing for the last two decades to enhance its contribution to the GDP, employment, regional, local economy, and to strengthen the balance of payment. In particular, a planned economy was introduced to provide substantial opportunities to utilize tourism as a mechanism for national development. As a service-based sector, tourism as also considered to be a vehicle of converting the manufacturing economy to a service economy which makes the delivery of the product rather than the creation of the product the most important thing.
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