Judul: Studi Komponen Aktif Temu Lawak terhadap Patogenesis Kanker Kolorektum Jalur Protein β-Katenin dengan Penambatan Molekular
Abstrak: Chemotherapy of colorectal cancer can be carried out by inhibiting the activity of excessive β-catenin protein in the body with anticancer compounds. One of the potential plants as anticancer is temu lawak (Curcuma xanthorrhiza). The molecular docking method can be used to determine the potential activity and efficiency of temu lawak bioactive compounds to inhibit the colorectal cancer through β-catenin protein pathway. The docking results of 24 active components in temu lawak against 14 proteins in β-catenin pathway obtained 3 potential bioactive anticancer compounds, namely dihydrocurcumin, demethoxycurcumin, and curcumin. The bioactive compounds could inhibit the colorectal cancer through the axin protein in β-catenin pathway. The interaction were observed based on several parameters: Gibbs free energy (ΔG), affinity (pKi), inhibition constant (Ki), efficiency, and hydrogen bonding. The results from the docking process were better compared with the XAV939 and IWR standards which have been known as inhibitors of colorectal cancer in axin protein.
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Judul: Molecular Docking of Compounds of Ethanol Extract of Temu Ireng Rhizome (Curcuma aeruginosa Roxb.) as Antioxidant and Anticancer.
Abstrak: Kanker merupakan salah satu jenis penyakit berbahaya yang mengalami peningkatan kasus setiap tahunnya. Radikal bebas merupakan penyebab mutasi gen yang dapat memicu kanker. Kanker akan berkembang tanpa terkendali karena terjadinya disregulasi siklus sel dan adanya senyawa pemicu proliferasi sel serta penghambat proses apoptosis. Pengobatan kanker dilakukan dengan memberikan inhibitor cyclin dependent kinase2 (CDK2) dan cyclooxygenase-2 (COX-2) untuk menghambat perkembangan kanker, serta inhibitor lipoxygenase (LOX) untuk menghambat pembentukan radikal bebas. Tanaman temu ireng diketahui memiliki potensi sebagai antioksidan dan antikanker. Penelitian ini bertujuan mengetahui interaksi molekuler antara senyawa dominan ekstrak etanol temu ireng dengan CDK2, COX-2, dan LOX sebagai reseptor. Jenis interaksi ligan dengan reseptor ditentukan melalui parameter energi afinitas (ΔG), konstanta inhibisi (Ki), jenis interaksi dan persentase binding site similarity (%BSS). Hasil penelitian menunjukkan bahwa senyawa uji gajutsulacton A memiliki potensi terbaik dalam menghambat CDK2. Senyawa uji cucumenol berpotensi sebagai inhibitor COX-2 tetapi tidak terdapat senyawa yang dapat menghambat LOX dengan baik sebagai antioksidan., Cancer is one type of dangerous disease that is increasing every year. Free radicals are the cause of gene mutations which can lead to cancer. Cancer will develop uncontrollably due to the dysregulation of the cell cycle and the presence of compounds which trigger cell proliferation and inhibit the process of apoptosis. Cancer treatment is carried out by giving cyclin-dependent kinase2 (CDK2) and cyclooxygenase-2 (COX-2) inhibitor drugs to inhibit cancer development, as well as lipoxygenase (LOX) inhibitor drugs for the formation of free radicals. The temu ireng plant is known to have the potential as an antioxidant and anticancer. This study aims to determine the molecular interaction between the dominant compound of temu ireng ethanol extract with CDK2, COX-2, and LOX receptors. The type of ligand interaction with the receptor was determined through the parameters of affinity energy (ΔG), inhibition constant (Ki), type of interaction, and percentage of binding site similarity (%BSS). The results showed that the test compound gajutsulacton A had the best potential in inhibiting CDK2. The test compound cucumenol may be a COX-2 inhibitor and there are no compounds that can inhibit LOX well as an antioxidant.
Keyword: Anticancer, Antioxidant, CDK2, COX-2, LOX

Judul: Gelombang soliter internal pada lapisan atmosfiri yang memiliki perubahan kecepatan angin yang cepat
Abstrak: Gelombang internal adalah suatu gelombang yang terjadi di dalam suatu fluida. Gelombang ini muncul karena adanya perubahan rapat massa di setiap lapisan di dalam fluida. Salah satu gelombang internal yang ditemui di lappisan atmosfir adalah gelombang soliter internal, seperti yang terjadi pada fenomena "morning glory" di Australia. pada fenomena "Morning glory" terjadi penurunan tekanan hingga bebrapa milibar.
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