Judul: The Model of Physical Exercise Effect on the Dynamics of Glucose and Insulin
Abstrak: Regular physical activity is indicated either to prevent or delay the onset of non-insulin-dependent diabetes or to assure a good control of diabetes by increasing insulin sensitivity and ameliorating the metabolism of glucose disappearance. A minimal model developed previously was extended to include the major effects of exercise on plasma glucose and insulin levels. Minimal model of glucose and insulin dynamics created in this study is valid. Result of model simulation is good agreement with experimental data. On the normal subject, physical exercise can reduce blood glucose levels, the same thing happened in people with diabetes. In general, the model can be explained that physical exercise can lower glucose levels basal while after the exercise, but will eventually rise returned to initial basal glucose levels, so to keep the blood glucose remained normal should be done exercise regularly and with the assistance of insulin therapy appropriate to the needs of patients.
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Judul: Simulation of Modified Minimal Model for Glucose and Insulin Mechanism in Type 2 Diabetes and Healthy Humans
Abstrak: Bergman minimal model is Mathematics model which is invented by Richard N. Bergman in 1979. That model consists of three compartments to predict glucose effectiveness (SG) and insulin sensitivity (SI) from the intravenous glucose tolerance test (IVGTT) data in a period of time. A lot of modifications from bergman minimal model have been made with the purpose to increase the accuracy and to handle process complexity in glucose-insulin mechanism system. Minimal model can be used in health to diagnose, to prevent, and to treat diabetes patients. In this research, mathematics model is modified based on the assumption that insulin enters the plasma insulin compartment at a rate proportional to the product of time and the glucose concentration above a basal plasma glucose concentration. If the plasma glucose concentration drops below the basal plasma glucose concentration, so insulin rate which enters the plasma glucose compartment is zero. Insulin is cleaned from the plasma insulin compartment at a rate proportional to the amount of insulin in the plasma insulin compartment. This model is also modified based on the assumption that the insulin decay rate is not always a first order process and function identification from insulin infusion rate. Modified minimal model that is obtained in this research consists of three ordinary diferensial equations. The first and second diferensial equations state that the influence of insulin to speed up glucose absorption, whereas the third diferensial equation states that the influence of glucose to increase insulin secretion. The accuracy of modified minimal model working is tested by comparing the simulation result of modified minimal model with the simulation result by Zheng and Zhao and the experiment result from the previous study which is done by Jiaxu et al. The simulation from that ordinary diferensial equation is accomplished using ode45. In general, modified minimal model is applied to healthy humans and type 2 diabetes patients which is then divided into four conditions based on the amount of exogenous insulin infusion that is applied in MATLAB (Matrix Laboratory). On the first condition, model simulation in healthy humans without giving insulin infusion. That simulation result shows that after giving glucose injection to the body, glucose reaches higher concentration and returns to basal condition within one hour. When giving glucose injection, the signal is sent to pancreas, β cells in islands of langerhans reacts by producing insulin hormone. This condition is signed with the increase of insulin concentration in the body. After that, insulin concentration decreases and forms little peak. Insulin hormone functions to process glucose so that it can be absorbed by body cells. Within one hour insulin concentration will return to basal level because there is no glucose that should be processed anymore. It presents that pancreas responsiveness is excellent, in which β cells are able to secrete enough insulin to keep blood glucose concentration in normal condition. On the second condition, that is model simulation in healthy humans by giving exogenous insulin infusion on the 20th minute for 5 minutes as much as 30 mU kg-1 body weight. Glucose concentration of healthy humans will return quickly to
Keyword: modified minimal model, glucose,, insulin, type 2 diabetes

Judul: Kearifan Tradisional Perlindungan dan Pemanfaatan Sumberdaya Hutan oleh Suku Kanume di Taman Nasional Wasur
Abstrak: Wasur National Park (TN Wasur), is located in Merauke, Papua. The Kanume tribe is one of indigenous communities who have long been living in TN Wasur, which has the region's largest in TN Wasur, about 305.312 ha (73,78%). This study was conducted to analyze the pattern of protection and use of forest resources by the tribe Kanume in the Wasur National Park. The results showed that the people of clans in the ethnic of Kanume has a custom rules and wisdom in terms of protection and utilization of forest resources. Clans in the tribe of Kanume has ownership rights at the ulayat land to protect and exploit resources that there can be found sacred places, the old village, the well nature, hamlet of sago, and places the ancestral journey. In traditional wisdom and resource utilization, the tribe of Kanume have a culture that supports the management of the forest resource. This can be seen by the existence of the division of conception space based on the area of ulayat customs, the system of mastery and ownership of land, Sasi system and the belief of Totem(Totemism).
Keyword: traditional wisdom, Taman Nasional Wasur, Suku Kanume