Judul: Farmakologi Balik dan Jejaring untuk Pencarian Senyawa Aktif dari Jamu Antidiabetes
Abstrak: One of the attempts to treat diabetes is by using herbal medicines. The explanation of molecular mechanism from medicinal plant (herb) compounds such as their interaction with target proteins still to be developed. The aims of the research are to find potential active compounds from antidiabetic medicinal plants, to find their molecular mechanism of inhibition, and to check potentiality of herbal formula plants as antidiabetic through study of reversed and network pharmacology. Antidiabetic potential compounds and molecular mechanism were discovered by analyzing networks formed between compounds of clinical trial plants, lead compounds such as antidiabetic standards, and compounds of herbal formula plants. There are 10 potential compounds obtained from networks and further evaluated for their drug-likeness using the rule of five. The evaluation revealed 8 compounds that meet the rule and further confirmed their activity on the target through molecular docking. The result of docking showed that 3,4- dihydroxybenzoic acid, berberine, and (-)-secoisolariciresinol gave better affinity than that of the target protein‟s inhibitor standard, thus these compounds are potential to play a role in the treatment of diabetes.
Keyword: Bogor Agricultural University (IPB), reversed pharmacology, network pharmacology, herbs, antidiabetic,

Judul: Farmakologi Balik dan Jejaring untuk Pencarian Senyawa Aktif dari Jamu Antihiperkolesterolemia
Abstrak: Efforts using variety of medicinal plants as antihypercholesterolemic have been widely carried out. However, the active compounds are responsible in the inhibition mechanism is not known yet. The aim of this study is to find the antihypercholesterolemic active compounds that play a role in inhibiting cholesterol accumulation from herbs of bidara upas, kemuning, kumis kucing, and jati belanda through using reversed pharmacology and network pharmachology. The active compound was searched based on an analysis of network between the active compounds in herbs formula toward the active compounds in lead plants, pharmacological effects, lead compounds and its similarity. The results of network evaluation and drug likeness test showed that the compounds with antihypercholesterol potential were geraniol, caffeic acid, and kaempferol. The antihypercholesterol activities were verified by molecular docking of these three compounds and can be proved to have antihypercholesterol activities which are better than the standard inhibitor.
Keyword: Bogor Agricultural University (IPB), molecular docking, drug likeness, tihypercholesterolemic

Judul: Characterizations of low alloy steel sae 4422  plated with chromic acid (Cro3)
Abstrak: Characterizations of low alloy steel SAE 4422 plated with chromic acid (CrOrO3) was use Optical Microscopy (OM), Scanning Electron Microscopy (SEM), X-Ray Diffraction (XRD), RD),Energy Dispersive Analysis of X-Ray (EDAX), Hardness Test and Roughness Test. Microstructures analysis exhibits cracks and grain boundaries microcracks as a characteristics of chrome metal found at plating metal. Perlite and Ferrite as grains of steel found at base metal with grain boundaries around it. Phase analysis of plating metal appropriate to chrome metal with lattice constant (a) is 2.559 Å and phase analysis of base metal appropriate to iron ferrite with lattice constant (a) is 3.318 Å. Both plating and base metal have cubic system. Chemical analysis of plating metal at surface section exhibits that cracks area have highest value of carbon element compare with grains and grains boundaries area. While chemical analysis of base metal at cross section exhibits that perlite have highest value of carbon element compare with ferrite and grain boundaries. The hardness value of plating metal at surface section and cross section are 753 and 637 VHN. While, the hardness value of base metal and interface area at cross section are 205 and 373 VHN. The roughness value at measurement points of chrome surface for as received sample are 0.445 μm. Observation used Optical Microscopy and Scanning Electron Microscopy exhibits surface irregularities combine to form surface texture of plating metal at surface section.
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