Judul: Fraksi Ekstrak Biji Mahoni (Swietenia macrophylla) dan Studi Pustaka Antikanker Sel MCF-7, T47D, serta HCT116
Abstrak: Kanker merupakan salah satu penyakit tidak menular yang menjadi masalah kesehatan masyarakat. Pertambahan jumlah penderita kanker yang semakin banyak, mendorong dilakukannya pencarian senyawa antikanker baru. Ekstrak biji mahoni (Swietenia macrophylla) adalah produk tumbuhan yang dilaporkan memiliki aktivitas antikanker. Penelitian ini bertujuan mendapatkan fraksi aktif yang memiliki aktivitas antikanker dari spesies tersebut dan menentukan aktivitas dari ekstrak atau fraksinya terhadap sel MCF-7, T47D, dan HCT116. Fraksionasi ekstrak etil asetat menggunakan kromatografi cair vakum menghasilkan 5 fraksi dengan rendemen antara 3.73% (Fraksi 4) dan 42.22% (Fraksi 3). Hasil studi pustaka ekstrak etanol menunjukkan aktivitas antikanker terhadap sel HCT116 dan MCF-7. Ekstrak etil asetat dan fraksinya dilaporkan sitotoksik terhadap sel kanker MCF-7 dan T47D. Senyawa aktif tersebut diduga adalah golongan limonoid.
Keyword: Sel HCT116, MCF-7, T47D,, Swietenia macrophylla

Judul: Bioaktivitas Biji Mahoni Berdaun Lebar (Swietenia macrophylla) sebagai Antikanker
Abstrak: There are three species of mahogany in Indonesia, namely small-leaf mahogany (Swietenia mahogany), broad-leaf mahogany (Swietenia macrophylla), and Swietenia sp. This study aimed to study the toxicity of bioactive compounds in fractions of ethyl acetate extract from broad-leaf mahogany seeds, which is potencial as anticancer, by using brine shrimp lethality test. The seeds were ground into powder and air-dried. The powder was then soxhletized with nhexane. The residue was macerated in 96% ethanol. The ethanol extract was evaporated and then extracted by using liquid-liquid extraction with 1:1 ethyl acetate-water. The ethyl acetate extract yield was 5.7% (w/w). The ethyl acetate extract was further fractionated by using column chromatography with gradien elution with chloroform and ethyl acetate. Four fractions were obtained with fraction 1 (Rf = 0.95 in 1:1 chloroform-ethyl acetate eluent) was the most active fraction with LC50 of 35.46 ppm and 12% (w/w) yield. This result showed that fraction 1 was potencial as anticancer. Phytochemical test of fraction 1 gave positive results for alkaloids, saponins, steroids, triterpenoids, and tannins.
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Judul: Perubahan Penggunaan/Tutupan Lahan Tahun 1990-2005 dan Proyeksi Perubahan Tahun 2020-2035 di Kawasan Jabodetabek
Abstrak: Rapid population and economic activities growths in Jabodetabek cause more demand for urbanization. People tend to convert their land to land uses that provide higher land rent. This research aims to describe land use/cover change in the Jabodetabek region from 1990 to 2005, to analyze the spatial pattern of land use/cover changes in the Jabodetabek region from 1990 to 2005, and to forecast the land use/cover for 2020 and 2035. The results of this study show that the land use/cover in 1990, 1995, and 2005 was dominated by paddy field, which were respectively 256.757 Ha (37.7%), 258.638 ha (37.9%), and 254.670 ha (37.4%). In that period, the paddy field was also experiencing the largest land use/cover conversion into other uses. Meanwhile, the built-up area experiencing the largest increase, reached 92.604 ha in 2005. Jabodetabek area in 2020 is expected to be dominated by paddy fields as well as as built-up, whereas in the year 2035, built-up area to be the largest land use/cover areas in Jabodetabek region. Forest area, water bodies, paddy field as well as other agricultural uses will continue to decrease since 2005. On the other side, in the built up 2020 and 2035 the built up areas will continue to increase. The largest type of land use/cover change in Jabodetabek region is the conversion of paddy field in built-up area.
Keyword: Land use forecast, Land use/cover change, Jabodetabek region