Judul: Hematology and Liver Enzymatic Activity of Hypercholesterolemia Rats Given “Emping-Dadih”
Abstrak: Hypercholesterolemia is a condition of high cholesterol in the blood. It can lead to death due to occurring cardiovascular disease. Prevention and treatment of hypercholesterolemia using traditional food black glutinous rice and fermented buffalo milk (“emping-dadih or ED”) may affect blood profiles and liver enzymatic activity. This study aimed to analyze various parameters of red blood cells, white blood cells, and thrombocytes, also liver enzymatic activities of rat giving high-cholesterol and ED. This study was conducted using 25 male Sprague-Dawley rats divided into five treatment groups, namely negative control (A), positive control/hypercholesterolemia (B), ED prevention (C), ED treatment (D), and atorvastatin treatment (E). Hematology and liver enzymatic comparison for all groups were analyzed by descriptive and ANOVA. The results showed that ED increased the number of erythrocytes, decreased the number of platelets and leukocytes as indicators decreased of inflammation. “Emping-dadih” also significantly reduced SGPT/ALT and SGOT/AST activities than in hypercholesterolemia conditions. This study showed that “emping-dadih” was able to improve the hematological profile and enzymatic activity of the liver in hypercholesterolemia rats., Hiperkolesterolemia adalah suatu kondisi kolesterol yang tinggi di dalam darah. Hal ini dapat menyebabkan kematian karena memicu terjadinya penyakit kardiovaskular. Pencegahan dan pengobatan hiperkolesterolemia menggunakan pangan tradisional beras ketan hitam dan dadih (“emping-dadih” atau ED) dapat memengaruhi profil darah dan aktivitas enzimatis hati. Penelitian ini bertujuan menganalisis berbagai parameter sel darah merah, sel darah putih, dan trombosit, serta aktivitas enzimatis hati tikus yang diberikan kolesterol dan ED. Penelitian ini dilakukan dengan menggunakan 25 ekor tikus jantan Sprague-Dawley yang dibagi menjadi lima kelompok perlakuan, yaitu kontrol negatif (A), kontrol positif/hiperkolesterolemia (B), pencegahan ED (C), pengobatan ED (D), dan pengobatan atorvastatin (E). Perbandingan hematologi dan enzimatis hati untuk semua kelompok dianalisis secara deskriptif dan ANOVA. Hasil penelitian menunjukkan bahwa ED meningkatkan jumlah eritrosit, menurunkan jumlah trombosit dan leukosit sebagai indikator penurunan inflamasi. “Emping-dadih” juga secara signifikan mengurangi aktivitas SGPT/ALT dan SGOT/AST dibandingkan dengan kondisi hiperkolesterolemia. Penelitian ini menunjukkan bahwa “emping-dadih” mampu memperbaiki profil hematologi dan aktivitas enzimatis hati pada tikus hiperkolesterolemia.
Keyword: dadih, emping, hematology, hypercholesterolemia, liver enzymatic

Judul: Efficacy of Dadih and Black Glutinous Rice as an Cholesterol Lowering Alternative (Antihypercholesterolemia) in Hypercholesterolemic Rats Model
Abstrak: Hiperkolesterolemia merupakan faktor resiko penyakit kardiovaskular seperti aterosklerosis. Penelitian ini bertujuan menganalisis kadar total kolesterol, trigliserida, High Density Lipoprotein (HDL), dan Low Density Lipoprotein (LDL) dalam darah, serta kolesterol organ hati pada tikus hiperkolesterolemia yang diberi dadih dan ketan hitam (emping-dadih) dibandingkan dengan obat atorvastatin. Penelitian ini menggunakan 10 ekor tikus putih yang dibagi menjadi dua kelompok perlakuan, yaitu kelompok “emping-dadih” (ED) dan atorvastatin (AT). Penelitian dilaksanakan 9 minggu mencakup 5 minggu pertama diberikan diet kolesterol 1%, dan 4 minggu terakhir kelompok ED diberikan “emping-dadih” serta kelompok AT diberikan atorvastatin. Berdasarkan studi ini dapat disimpulkan bahwa “emping-dadih” dengan dosis tertentu mempunyai kemampuan yang sama dengan atorvastatin dalam menurunkan kadar kolesterol total dan LDL. Keduanya tidak memiliki efek berbeda terhadap kadar HDL. “Emping-dadih” berpotensi menaikkan kadar trigliserida walaupun dalam studi ini masih dalam rentang normal. “Emping-dadih” juga mampu menjaga kadar kolesterol hati tikus sama seperti kelompok yang diberi atorvastatin., Hypercholesterolemia is a risk factor for cardiovascular diseases such as atherosclerosis. This study aimed to analyze the levels of total cholesterol, triglycerides, High Density Lipoprotein (HDL), and Low Density Lipoprotein (LDL) in the blood, as well as liver cholesterol in hypercholesterolemic rats given dadih and black glutinous rice (emping-dadih) compared to atorvastatin. This study used 10 white rats divided into two treatment groups, i.e., the group treated with “emping-dadih” (ED) and the group treated with atorvastatin (AT). This study was conducted for 9 weeks. The first 5 weeks, all groups were given 1% cholesterol diet, and the last 4 weeks, the ED group was given emping dadih, and AT group was given atorvastatin. Based on this study, “emping dadih” can be concluded that “emping-dadih” with a certain dose has the same ability as atorvastatin in reducing total and LDL cholesterol levels. Both also have no different effect on HDL levels. “Emping dadih” has a potential to raise triglyceride levels even though in this study it is still within the normal range. “Emping-dadih” also maintained liver cholesterol levels the same as the atorvastatin rat group with no noticeable difference.
Keyword: black glutinous rice, dadih, hypercholesterolemia, LDL, Rat

Judul: Analisis pemanfaatan ruang wilayah pesisir dalam pelaksanaan otonomi daerah di kabupaten Buru, Maluku
Abstrak: Buru regency as one of the newest region in Moliccas province, as the implementation on decentralization laws, have a big potential in development and management of their coastal zone.
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