Judul: Inhibisi Ekstrak Air Kumis kucing dan Tempuyung terhadap Aktivitas ACE (Angiotensin Converting Enzyme) secara In Vitro
Abstrak: Angiotensin converting enzyme (ACE) plays an important role in the regulation of blood pressure. ACE works by converting inactive decapeptide angiotensin I to angiotensin II which can increase blood pressure (hypertension). Kumis kucing and tempuyung plants were macerate using water and the yield were 11% and 9%, respectively. Total flavonoid content of kumis kucing and tempuyung’s extracts were 2.33×10-1% and 1.07×10-1%, respectively. The ACE inhibitory activity were tested and gave 69% for single extract of 50 ppm kumis kucing, 40% for single extract of 50 ppm tempuyung, and 88% for captopryl (control) at 25 ppm concentration. The inhibition of a single extract kumis kucing at a concentration of 50 ppm can be a natural ACE inhibitors and may is potential as an antihypertensive.
Keyword: Bogor Agricultural University (IPB), tempuyung, kumis kucing, antihypertensive, ACE

Judul: Potensi Ekstrak Air dan Etanol Kumis Kucing, Pegagan, Tempuyung, dan Sambiloto sebagai Antihipertensi serta Profil Senyawa Pencirinya.
Abstrak: Kumis kucing, pegagan, tempuyung, and sambiloto are widely used as medicinal plants to treat a variety of diseases, such as hypertension. The objective of this researchs was to determine inhibitory activity of water extracts and 30% ethanol extract of these plants against ACE through in vitro assay. Three extracts with the highest inhibitory activity were formulated by using mixture design and its inhibitory activity against ACE was investigated. The result showed that 30% ethanol extract of pegagan, 30% ethanol extract of kumis kucing, and water extract of kumis kucing showed three of the highest inhibitory activity. Formulation of these extracts in composition of 1/6:1/6:2/3 and concentration of 100 ppm showed inhibition against ACE that slightly lower than inhibition of captopril at 100 ppm. Analysis of marker compounds by using thin layer chromatography showed that sinensetin band detected under UV light at 254 nm and 366 nm. Meanwhile high performance liquid chromatographic analysis showed that the formula contain asiaticoside more than sinensetin.
Keyword: ACE inhibition, antihypertensive, asiaticoside, sinensetin

Judul: Massa Graviton Berdasarkan Teori De Rham- Gabadadze-Tolley Dalam Model Alam Semesta Datar Friedmann-Lemaitre- Roberson-Walker
Abstrak: Teori Relativitas Umum memprediksi ekspansi alam semesta diperlambat, sedangkan hasil observasi supernova tipe Ia mendapati ekspansi alam semesta dipercepat. Teori Relativitas Umum dimodifikasi melalui pendekatan teori gravitasi bermassa nonlinier oleh de Rham-Gabadadze-Tolley (dRGT). Massa graviton dimunculkan untuk dinamika skala sangat besar. Persamaan medan Einstein teori dRGT dapat dirumuskan dari prinsip variasi. Selanjutnya dengan memilih metrik datar Friedmann-Lemaitre-Roberson-Walker dapat diformulasikan bentuk persamaan Friedmann yang relevan dengan model ekspansi dipercepat. Hasil akhirnya, dengan membandingkan massa graviton dari metode Extremely Low Energy (ELE) dapat dihitung massa kritis graviton yaitu sekitar - . .
Keyword: massa graviton, teori dRGT, persamaan medan Einstein, persamaan Friedmann, ekspansi alam semesta dipercepat