Judul: Konsentrasi Hambat Minimum dan Toksisitas Senyawa Hasil Biotransformasi Kurkumin oleh Mikrob Endofit Asal Kunyit
Abstrak: Curcumin can be transformed into its derivative compound with the help of endophytic microbes. The biotransformed compound has been known to possess antibacterial activity toward Salmonella typhi and Staphylococcus aureus. This research was conducted to determine the Minimum inhibition concentration (MIC) of the biotransformed compound using agar diffusion method to find out Salmonella typhi's and Staphylococcus aureus's sensitivity against the biotransformed compound. In addition, the toxicity test based on lethal concentration 50 (LC50) with the Brine shrimp lethal test (BSLT) method against Artemia salina was performed as preliminary test in determining the biotransformed compound’s potency in the development of medicines. The MIC value of this compound against Salmonella typhi was 6.25 mg/mL with the clear zone diameter of 2.5 mm and 25 mg/mL against Staphylococcus aureus with the clear zone diameter of 2.5 mm. The LC50 value of the biotransformed compound was 131.272 ppm, higher than curcumin’s LC50, which is 82.153 ppm. This value was obtained by probit analysis using SPSS (Statistical Product and Service Solutions) program.
Keyword: 

Judul: Potensi Antibakteri Kurkuminoid dan Nanokurkuminoid Temulawak (Curcuma xanthoriza) Secara In Silico dan In Vitro.
Abstrak: Kurkuminoid termasuk senyawa yang cepat dimetabolisme. Bentuk nanoemulsi dapat menjadi alternatif untuk mengatasi permasalahan tersebut. Antibakteri pada umumnya menghambat pembentukan dinding sel. Enzim MurA berperan penting dalam pembentukan dinding sel bakteri. Penelitian mengenai fungsi kurkuminoid sebagai antibakteri secara in silico serta potensi nanokurkuminoid sebagai antibakteri belum pernah dilakukan. Penelitian ini bertujuan menguji potensi kurkuminoid sebagai antibakteri melalui uji penghambatan enzim UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) secara penambatan molekuler serta mengukur aktivitas antibakteri dari nanokurkuminoid menggunakan uji difusi cakram. Senyawa kurkuminoid menunjukkan nilai energi bebas Gibs lebih kecil dibandingkan dengan ligan pembanding. Nanokurkuminoid memiliki nilai MIC 200 μg/mL untuk ekstrak kasar pada bakteri Escherichia coli serta 400 μg/mL untuk bakteri Bachillus subtilis. Zona bening nanokurkuminoid mendekati dengan senyawa ekstrak kasar dengan konsentrasi senyawa aktif yang kecil. Senyawa kurkuminoid mampu menunjukkan aktivitas antibakteri baik secara in silico maupun dalam bentuk nanokurkuminoid secara in vitro.
Keyword: antibakteri, diffusi cakram, docking, enzim MurA, nanokurkuminoid

Judul: Pemodelan dan Solusi Game Mate In One Puzzle dengan Representasi Logika Answer Set Programming
Abstrak: Since the beginning of AI, mind games, such as Chess, have been studied as application fields for AI. Several variation of chess related problems have been shown to be NP-complete. This research deals with the problem of Mate in One Puzzles. We employ Answer Set Programming (ASP) to tackle this problem. ASP has been, in the last decade, the subject of active research in the field of logic programming, knowledge representation, and reasoning. ASP allows for an intuitive representation of computationally hard problems as well as efficient solving using state-of-the-art solvers, such as DLV. In this research, a representation of Mate In One Puzzles has been formulated and a prototype application system written using PHP and DLV has also been implemented. Experimental results show that the system is capable of generating solutions for Mate in One problem efficiently. However, the representation is still not efficient enough to be used for more difficult class of problems such as Mate in Two and Mate in Three.
Keyword: