Judul: Farmakologi Balik dan Jejaring untuk Pencarian Senyawa Aktif dari Jamu Antihiperkolesterolemia
Abstrak: Efforts using variety of medicinal plants as antihypercholesterolemic have been widely carried out. However, the active compounds are responsible in the inhibition mechanism is not known yet. The aim of this study is to find the antihypercholesterolemic active compounds that play a role in inhibiting cholesterol accumulation from herbs of bidara upas, kemuning, kumis kucing, and jati belanda through using reversed pharmacology and network pharmachology. The active compound was searched based on an analysis of network between the active compounds in herbs formula toward the active compounds in lead plants, pharmacological effects, lead compounds and its similarity. The results of network evaluation and drug likeness test showed that the compounds with antihypercholesterol potential were geraniol, caffeic acid, and kaempferol. The antihypercholesterol activities were verified by molecular docking of these three compounds and can be proved to have antihypercholesterol activities which are better than the standard inhibitor.
Keyword: Bogor Agricultural University (IPB), molecular docking, drug likeness, tihypercholesterolemic

Judul: Farmakologi Balik dan Jejaring untuk Pencarian Senyawa Aktif dari Jamu Antidiabetes
Abstrak: One of the attempts to treat diabetes is by using herbal medicines. The explanation of molecular mechanism from medicinal plant (herb) compounds such as their interaction with target proteins still to be developed. The aims of the research are to find potential active compounds from antidiabetic medicinal plants, to find their molecular mechanism of inhibition, and to check potentiality of herbal formula plants as antidiabetic through study of reversed and network pharmacology. Antidiabetic potential compounds and molecular mechanism were discovered by analyzing networks formed between compounds of clinical trial plants, lead compounds such as antidiabetic standards, and compounds of herbal formula plants. There are 10 potential compounds obtained from networks and further evaluated for their drug-likeness using the rule of five. The evaluation revealed 8 compounds that meet the rule and further confirmed their activity on the target through molecular docking. The result of docking showed that 3,4- dihydroxybenzoic acid, berberine, and (-)-secoisolariciresinol gave better affinity than that of the target protein‟s inhibitor standard, thus these compounds are potential to play a role in the treatment of diabetes.
Keyword: Bogor Agricultural University (IPB), reversed pharmacology, network pharmacology, herbs, antidiabetic,

Judul: Aplikasi Data SAR TerraSAR-X untuk Studi Deformasi Gunung Anak Krakatau Menggunakan Differential SAR Interferometry
Abstrak: Gunung Anak Krakatau adalah gunung api aktif yang terletak di Selat Sunda, Indonesia. Sejak bulan Juni hingga Desember 2018 terjadi peningkatan aktivitas vulkanik pada Gunung Anak Krakatau. Salah satu yang terjadi adalah erupsi pada 2 September 2018. Erupsi menyebabkan terjadinya deformasi pada permukaan gunung api. Analisis deformasi permukaan sangat penting untuk memahami proses dan bahaya vulkanik. Penelitian ini bertujuan untuk mengidentifikasi dan mengukur deformasi berdasarkan line of sight (LOS) displacement pada permukaan Gunung Anak Krakatau menggunakan teknik Differential SAR Interferometry (DInSAR). Pengukuran deformasi dilakukan menggunakan data SAR dari satelit TerraSAR-X yang diakuisisi pada Agustus dan September 2018 serta digunakan juga data DEM SRTM 90 m. Berdasarkan nilai LOS displacement diketahui erupsi yang terjadi pada 2 September 2018 mengakibatkan kenaikan permukaan tanah (inflasi) antara 0.294 m sampai 0.558 m. Secara umum inflasi yang terbesar terjadi pada lereng bagian Barat dan terus menurun hingga lereng bagian Timur. Inflasi permukaan tanah ini meningkatkan volume gunung sehingga mengurangi stabilitas lereng dan meningkatkan potensi tsunami.
Keyword: deformasi, DInSAR, erupsi, line of sight