Judul: Struktur komunitas ikan yang berasosiasi dengan ekosistem Padang Lamun di Perairan Tanjung Merah, Sulawesi Utara
Abstrak: Perairan Sulawesi Utara khususnya Tanjung Merah, mempunyai ekosistem padang lamun yang cukup yaitu mencapai panjang antara 174-240 meter. Secara ekologis dan ekonomis pada lamun menjadi penting karena menopang kehidupan biota laut di sekitarnya dan sedang mendapat tekanan akibat industri pelayaran yang berkembang di Bitung, Sulawesi Selatan.
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Judul: Struktur Komunitas Lamun di Perairan Pagerungan, Jawa Timur.
Abstrak: Perairan Pagerungan terletak di Kepulauan Kangean, Jawa Timur. Pada perairan tersebut terdapat tiga ekosistem yang produktif yaitu mangrove, terumbu karang dan padang lamun. Ekosistem lamun merupakan salah satu ekosistem di laut dangkal yang mempunyai peranan penting dalam kehidupan biota laut dan merupakan salah satu ekosistem bahari yang paling produktif, sehingga mampu mendukung potensi sumberdaya yang tinggi pula. Seiring dengan meningkatnya aktivitas di daerah pesisir, telah memberikan tekanan terhadap ekosistem padang lamun. Di lain pihak walaupun sudah mengalami tekanan, namun penelitian tentang lamun masih sangat sedikit. Padahal informasi tersebut sangat penting untuk mene1aah pentingnya manfaat lamun dan pengelolaannya di masa yang akan datang. Penelitian ini bertujuan untuk mengetahui struktur komunitas lamun di perairan Pagerungan. Hasil penelitian ini diharapkan berguna sebagai infomasi dasar untuk lebih memahami fungsi dan faktor ekologis serta informasi dasar dalam pemanfaatan serta pengelolaan padang lamun. Disamping itu juga untuk melengkapi informasi tentang keberadaan lamun di Indonesia.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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