Judul: Activity of breast anticancer of active compound from Spatholobus suberectus stem’s by in silico
Abstrak: Sekitar lebih 70% kasus kanker payudara adalah tipe positif hormon reseptor. Kasus kanker payudara tipe ini lebih banyak terjadi pada wanita post menopaus. Pengobatan yang efektif kasus ini adalah pemberian inhibitor enzim aromatase. Senyawa isoflavonoid batang Spatholobus suberectus telah teruji secara in vitro memiliki aktivitas sitotoksik terhadap sel kanker payudara MCF-7 yang banyak mengekspresikan reseptor estrogen dan enzim aromatase. Perlu dilakukan pencarian senyawa lain batang Spatholobus suberectus yang berpotensi memiliki aktivitas antikanker payudara. Penelitian ini bertujuan memprediksi potensi senyawa-aktif batang Spatholobus suberectus sebagai antikanker payudara melalui mekanisme penghambatan enzim aromatase secara in silico dengan metode penambatan molekular. Simulasi penambatan molekuler dilakukan melalui parameter energi ikat (ΔG), konstanta inhibisi (Ki), jenis interaksi dan binding site similarity (BSS). Senyawa aktif yang diprediksi memiliki potensi adalah prestegane B, 2R,3R-3,7-dihidroksiflavanon, dihidrorobinetin, asam protokatekuat etil ester, liquiritigenin, naringenin, 7,4’-dihidroksi-8-metoksi-isoflavone, asam protokatekuat, glisirosida, dulcisflavan, butein, hesperetin, plathymenin, isoliquiritigenin, dan medioresinol., Approximately over 70% of breast cancer cases are positive types of hormone receptors. Cases of this type of breast cancer are more common in post menopausal woman. An effective treatment of this case is the administration of aromatase enzyme inhibitors. The stem isoflavonoid compound Spatholobus suberectus has been tested in vitro has cytotoxic activity against MCF-7 breast cancer cells that expressed a lot of estrogen receptors and aromatase enzymes. It is necessary to search for other compounds of Spatholobus suberectus stem that have the potential to have anticancer activity of the breast. This study aimed to predict the potential of compound-active stem Spatholobus suberectus as an anticancer breast through the mechanism of inhibition of aromatase enzymes in silico by molecular docking method. Molecular tethering simulation is done through binding energy parameters (ΔG), inhibition constants (Ki), types of interaction and binding site similarity (BSS). Active compounds that was predicted to have potential are prestegane B, 2R,3R-3,7-dihydroxyflavanon, dihydrorobinetin, protocatechuic acid ethyl ester, liquiritigenin, naringenin, 7,4’-dihidroksi-8-metoksi-isoflavone, protocatechuic acid, glyciroside, dulcisflavan, butein, hesperetin, plathymenin, isoliquiritigenin, and medioresinol.
Keyword: molecular docking, inhibitor, aromatase

Judul: Potential of Limonoid in the Rutaceae Family as Receptor Obstacle for Breast Cancer using In Silico Analysis
Abstrak: Kanker payudara menjadi kasus kanker terbanyak di Indonesia dengan penderita terbanyak adalah wanita. Obat kanker payudara telah ditemukan, salah satunya tamoksifen, tetapi menimbulkan efek samping. Senyawa potensial sebagai obat antikanker payudara perlu ditemukan salah satunya melalui cara penambatan molekuler karena biaya penelitian yang murah dan waktu pengerjaan yang singkat. Ligan alami pada reseptor yang terekspresi dalam kanker payudara memiliki kemiripan bentuk dengan senyawa limonoid. Senyawa tersebut banyak ditemukan dalam famili Rutaceae. Penelitian ini bertujuan memprediksi senyawa limonoid dari famili Rutaceae yang berpotensi sebagai obat antikanker payudara melalui teknik penambatan molekuler. Hasil penambatan molekuler serta prediksi toksisitas dan farmakokinetik menunjukkan bahwa terdapat empat senyawa yang berpotensi sebagai obat antikanker payudara dengan ekspresi dominan reseptor progesteron, yaitu obakunon, 7α-obakunol, 7α-obakunil asetat, dan epoksiazadiradion. Keempat senyawa tersebut berpotensi dijadikan obat oral dan tidak toksik., Breast cancer has become the most cancer case in Indonesia, which is women are the main patient of the case. A cure for breast cancer has been found, one of them is tamoxifen, but it has side effects. Potential compounds as anticancer drugs need to be found, one of which is through molecular docking because the research costs are cheap and the processing time is short. Natural ligands on receptors expressed in breast cancer have a similar shape to limonoid compounds. Limonoid compounds are commonly found in the Rutaceae family. The goal of this study is to predict limonoid compounds from the family Rutaceae that have the potential as anticancer drugs for breast cancer through molecular docking techniques. The results of molecular docking, toxicity prediction, and pharmacokinetic prediction have shown that four compounds have the potential as breast anti-cancer drugs with a dominant expression of progesterone receptors, there are obacunone, 7α-obacunol, 7α-obacunyl acetate, and epoxyazadiradione. The four compounds can be used as oral drugs and are not toxic.
Keyword: breast cancer, in silico, limonoid, oral drug, Rutaceae

Judul: Approximation of the Median of Poisson Distribution Using the Relation of Poisson-Gamma Distribution
Abstrak: A major drawback of median is that median cannot usually be defined in closed form, even in the cases where their distribution functions are known. This study gives an approximation of the closed form for the median of the Poisson distribution by using the relation of Poisson-Gamma distribution. The approximation uses elementary techniques based on the monotonicity of certain sequences involving tail probabilities of the Poisson distribution and the Central Limit Theorem. Furthermore, a closed form expression for the mean absolute deviation 􀜧|􀜰􀰒 􀵆 􀜯􀝁􀝀􁈺􀜰􀰒􁈻| is also studied. The median is relevant because of the fact that it minimizes the mean absolute deviation of a Poisson random variable (􀜰􀰒􁈻 by considering median as central tendency.
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