Judul: Pengaruh anestesi xylazin-ketamin jangka panjang terhadap suhu tubuh dan elektrokardiogram kelinci
Abstrak: Kombinasi xylazin-ketamin merupakan anestetikum yang sering digunakan dalam medis kedokteran hewan. Tujuan penelitian ini adalah untuk mengetahui efek anestesi xylazin-ketamin jangka panjang terhadap suhu tubuh dan aktivitas listrik jantung kelinci. Anestesi diberikan secara intramuskular sebagai induksi dan secara intravena sebagai maintenance dengan menggunakan metode drip. Suhu tubuh dan profil listrik jantung direkam pada saat induksi dan maintenance (4 jam) dengan menggunakan termometer dan elektrokardiografi (EKG). Parameter EKG yang dibaca antara lain denyut jantung dan gelombang EKG pada Lead II yang meliputi ukuran R-R interval, gelombang P, P-R interval, kompleks QRS, Q-T interval, dan gelombang T. Durasi anestesi berpengaruh secara nyata (P<0.05) terhadap penurunan suhu tubuh, denyut jantung, pemanjangan R-R interval, pemanjangan durasi gelombang P, pemanjangan P-R interval, dan pemanjangan Q-T interval. Durasi anestesi tidak berpengaruh secara nyata (P>0.05) terhadap peninggian amplitudo gelombang P, perubahan durasi dan amplitudo kompleks QRS, serta perubahan amplitudo gelombang T. Anestesi xylazin-ketamin jangka panjang menyebabkan terjadinya hipotermia, bradikardia, pembesaran atrium, first degree AV block, pembesaran ventrikel, dan penghambatan potensial aksi. Kesimpulan dari penelitian ini menunjukkan anestesi xylazin-ketamin menyebabkan penurunan suhu tubuh dan perubahan aktivitas listrik jantung.
Keyword: Bogor Agricultural University, Institut Pertanian Bogor, IPB, Electrocardiography, Heart, Long-term, Rabbit, Xylazine-ketamine

Judul: Gambaran Fungsi Jantung Kelinci Domestik pada Pembiusan Jangka Panjang Xylazin-Ketamin dengan Pencitraan Ekhokardiografi
Abstrak: Combination of xylazine-ketamine are commonly used anesthesia in veterinary medicine either in the minor or mayor surgery. The purpose of this study was to determine the effect of long-term anesthesia xylazine-ketamine combination on heart dynamics or performace of domestic rabbit’s assessed using Motion-mode echocardiography imaging. Xylazine-ketamine was administered to the male adult rabbit intra muscular for induction and through intra vena drip method for 7 hours maintenance. Evaluation of heart performance was assessed by Motion-mode echocardiography imaging. The results showed that administration of long-term anesthesia causes effect on the rabbit heart such as decrease of LVW (left ventricular wall), HR (heart rate), SV (stroke volume), CO (cardiac output), FS (fractional shortening), and EF (ejection fraction) value and increase of LVID (left ventricular internal dimention), EDV (end diastolic volume) dan ESV (end systolic volume) value. These results clearly showed the decrease of cardiac performance due to administration of long-term anesthesia that will inhibit the release of norepinephrine through the pressure of the sympathetic nervous system. The conclusion of this study is the long-term anesthesia xylazine-ketamine will result in a decrease of cardiac performance.
Keyword: xylazine-ketamine., long-term, heart, echocardiography, esthetica

Judul: Pengoptimuman Alignment Struktur Protein Menggunakan Clique Maksimum
Abstrak: An alignment of protein structures describes the relationship of two types of proteins similarity function. The problems of the protein structure alignments can be identified through the problems of the Contact Map Overlap (CMO). The problems of CMO can be solved by finding a maximum clique in a graph, where vertices and edges represent the amino acids and contacts between any two amino acids respectively. In this paper, the problem of finding maximum cliques is using two main steps, the arranging vertices and edges based on the special properties of the graph and preprocessing vertices. Implementation of the model is done by using the structure of a hypothetical protein.
Keyword: Contact Map Overlap, alignments, protein, maximum cliques