Judul: Kelembagaan Lokal : Bentuk Adaptasi Sosio-Ekologi Daerah Rawan Longsor (Kasus Kampung Sirnagalih, Desa Sukaraksa, Kabupaten Bogor, Provinsi Jawa Barat).
Abstrak: Landslides have damaged the cultivated land, settlements, and other infrastructures. Such damages have led the people to make adaptation as a survival strategy. The objective of this study are to describe and analyze: (1) the reality of landslides, (2) the people perceptions of both environment and their ability as well as self-confidence (3) the shapes of socio-ecological adaptation landslide-prone, and (4) the local institutions of landslides areas. The location of this study in Sirnagalih Kampong, Sukaraksa Village, Bogor Regency, West Java. The study used a combination of two techniques of data collection: a quantitative technique to measure perception, and a qualitative technique to explore the reality of landslides, the forms of socio-ecological adaptation and the local institutions of landslide communities. The result of this study reveals that the reality of landslides-prones have changed the people perceptions about environment, and pushed the shapes of socio-ecological adaptation. Further, the shape of adaptation is followed by the norms to manage and use the natural resources. Besides, the shapes of adaptation affect the availability of local institutions in landslide-prones communities.
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Judul: Estimasi Nilai Kerugian Ekonomi dan Upaya Mitigasi Terhadap Bencana Longsor (Studi Kasus : Desa Cibunian, Kabupaten Bogor)
Abstrak: Landslides often caused casualties and material losses. Landslides continued to occur every year in Cibunian village, especially during the rainy season. This studied aims to provided information related to factors causing landslides, landslide risk assessment, estimation of economic losses due to landslides and recommendations for landslide mitigation and adaptation strategies. The methods used include disaster risk calculation, actual market price approached, costed of illness, loss of income, and qualitative descriptive analysis. The results showed that the factors causing landslides in Cibunian village were high rainfall and lack of greenery. The analysis of disaster risk leveled shows that one rw fell into the high risk category, while the other rw fell into the medium risk category. The estimated valued of economic losses due to landslides reached rp 5,012,702,332, including community losses of rp 133,202,332 and losses borne by the government of rp 4,879,500,000. Recommendations for mitigation strategies that could been applied include reducing the birth rate, implementing building codes, and increasing community capacity.
Keyword: adaptation, economic loss estimation, landslide, landslide risk

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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