Judul: Gambaran Fungsi Ginjal Anjing Beagle yang Diberi Preparat Afoxolaner dan Milbemycin Oxime Tiga Kali Dosis
Abstrak: Anjing (Canis familiaris) menjadi salah satu hewan peliharaan yang banyak diminati manusia, sehingga menjaga kesehatan anjing menjadi hal yang penting agar anjing terhindar dari berbagai penyakit. Belakangan ini telah diperkenalkan obat antiparasit berbahan aktif afoxolaner dan milbemycin oxime (NexGard Spectra® ). Penelitian ini bertujuan untuk mempelajari pengaruh pemberian obat berbahan aktif afoxolaner dan milbemycin oxime sebanyak tiga kali dosis anjuran pada gambaran fungsi ginjal secara akut. Sebanyak tiga ekor anjing ras beagle yang sehat secara klinis masing-masing diberi sediaan berbahan aktif afoxolaner dan milbemycin oxime sebanyak tiga kali dosis anjuran secara oral. Setelah 24 jam pascapemberian obat antiparasit, sampel darah diambil melalui vena cephalica antebrachii untuk dianalisis kadar BUN dan kreatinin. Hasil pengamatan menunjukkan tidak ada perbedaan nyata kadar BUN dan kreatinin tiap individu anjing (P>0.05). Rata-rata kadar BUN dan kreatinin pada semua anjing berada dalam rentang nilai normal. Hal ini menunjukkan bahwa pemberian obat antiparasit berbahan aktif afoxolaner dan milbemycin oxime sebanyak tiga kali dosis anjuran tidak mempengaruhi parameter fungsi ginjal.
Keyword: afoxolaner, BUN, kreatinin, milbemycin oxime

Judul: Profil Eritrosit Anjing Beagle yang Diberikan Obat Antiparasit Kombinasi Afoxolaner dan Milbemycin Oxime 3 Kali Dosis Anjuran
Abstrak: Pengobatan ektoparasit maupun endoparasit sangat beragam, baik ragam dalam jenis obat maupun aplikasi pemberiannya. Penelitian telah menemukan entitas baru antiparasit peroral yang merupakan kombinasi afoxolaner yang efektif pada caplak dan pinjal, dan milbemycin oxime yang efektif pada nematoda. Penelitian ini bertujuan untuk menganalisis pengaruh sediaan kombinasi afoxolaner dan milbemycin oxime pada profil eritrosit anjing yang diberi 3 kali dosis anjuran. Sebanyak 3 ekor anjing beagle diberikan perlakuan berupa pemberian kombinasi antiparasit afoxolaner dan milbemycin oxime tiga kali dosis anjuran. Sampel berupa darah diuji menggunakan haematology analyzer. Hasil penelitian menunjukkan secara umum gambaran eritrosit tidak mengalami perubahan yang signifikan setelah pemberian sediaan kombinasi afoxolaner dan milbemycin oxime 3 kali dosis. Analisis darah secara statistik tidak menunjukkan adanya perbedaan nyata pada jumlah jumlah eritrosit, kadar hemoglobin, nilai hematokrit dan juga nilai indeks eritrosit. Hal ini menunjukan bahwa, pemberian obat kombinasi afoxolaner dan milbemycin oxime hingga 3 kali anjuran tidak memengaruhi eritrosit.
Keyword: afoxolaner, milbemycin oxime, anjing, eritrosit

Judul: Thermal Characteristics and Dynamics of Tropical Cyclone over Western North Pacific Ocean: A Case Study of Typhoon Songda (Chedeng) 2011
Abstrak: The frequent occasion of Tropical Cyclone (TC) over Western North Pacific (WNP) Ocean lies from 10˚N to 26˚N and 121˚E to 170˚E. Sources of TC development come from warm ocean temperature where latent heat is released during condensation processes and subsequently concentrated in the boundary layer. Relative humidity at 850-700 hPa is responsible to produce the most intense storm. Meanwhile, weak vertical wind shear between 850-200 hPa is one of the dynamical factors that lead to the development of TC. Pressure level of 850-200 hPa is chosen to minimize the thermodynamic effect in the lower troposphere. Typhoon Songda (Chedeng in the Philippines) or TSC lasted from May 18th to 30th, 2011 and strengthened into powerful Super Typhoon stage between May 24th and 27th. Long curving track and the exhibition of all sequences of TC life cycle, TSC is then considered as an ideal case of TC. The objective of the study with case of TSC is to investigate the role of thermal characteristics and dynamics on TC intensity. The research is carried out by using Advanced Research of Weather Research and Forecasting model (WRF ARW model) version 3.3. Two domains are employed in the model. The first domain situate from 02˚N to 40˚N and 118˚E to 149˚E and cover spatial resolution () of 33.1 km. The second domain situate from 09˚N to 27˚N and 119˚E to 132˚E with of 11 km. Timestep of the model () is 120 seconds. The model is supported by the following physical parameterization, i.e., Yonsei University Scheme (YSU) in the boundary layer, Kain-Fritsch scheme (KF) in the cumulus, and WRF Single-Moment 3-class scheme in the microphysics. Initial meteorological condition prior to the formation of the cyclone is generated using WRF ARW standard-release model. Sensitivity of the model output is obtained from a selected single-parameter change scenarios, namely, 10 % to 20 % decrease and increase of wind shear initial data at 850-200 hPa, and by 10 % to 20 % decrease of relative humidity initial data at 850-700 hPa. The result showed that the negative correlations between wind shear and intensity are found in wind shear scenarios. Wind shears of 10 ms-1 which lead to strengthening of the wind intensity in the early period of Typhoon development are found in wind shear scenarios. The effect of wind shear changes on wind intensity is statistically significant in the 20 % wind shear scenarios. During mature stage, weak wind intensity occurred when wind shear increase as given in the WRF standard-release and the 20 % decreasing scenario. Different situation is found in the 20 % increasing scenario where wind shear tend to weak and lead to strong wind intensity at this stage. Meanwhile, the reduction of moisture supply at 850-700 hPa resulting from 20 % decreasing relative humidity play a major role in the weakening of wind intensity and reduces mechanical energy of the cycle process as much as 300 J kg-1.
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