Judul: Analysis of increasing ext reme weather intensity in Jabota (Jakarta, Bogor, Tangerang) Period 1980 - 2008
Abstrak: spaces. This changes causes rising of air temperatures and hence increasing frequent events of extreme weather. Based on research in Taiwan, China and Japan, its have been proven that the existence of rising temper ature and frequent extreme weather were caused by land use changes. Daily observed data from Meteorological Stations around urban area of Jabota during the period 1980-2008 was used to determine the increase of air temperature and the frequency of extreme weather events. Besides the surface air temperature, the upper air temperature data period 1988-2008 was also analysed data to examine the increase of air temperature at particular layer. Further, hourly weather data of 2003-2008 from Meteorological Stasion Curug has been used as an example to analyze the time shifts of maximum air temperature and the time of thunderstorms occurrence. The analysis resulted an increase in average temperature in the latest period; increasing frequency of temperatures above 34° C, the increasing frequency of extreme precipitation at some months, especially in the rainy and transition seasons; the increasing frequency of thunderstorms occurrence, the increase of average upper air temperature, especially at surface layer up to 500 mb layer. The results also showed that the maximum temperature occurrence at certain months in dry and transition season to 02: 00 pm and the mostly hour of thunderstorms occurrence was 03: 00 to 05: 00 and from 07: 00 to 08: 00 pm.
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Judul: Analisis Peningkatan Intensitas Cuaca Ekstrim Di JABOTA (Jakarta, Bogor, Tangerang) Periode 1980 - 2008
Abstrak: Pertumbuhan penduduk mempengaruhi perubahan penggunaan lahan terutama berkurang ruang terbuka hijau. Hal ini mempengaruhi naiknya suhu udara dan meningkatnya cuaca ekstrim. Penelitian di beberapa negara sudah terbukti adanya kenaikan suhu dan cuaca ekstrim sebagai akibat dari perubahan penggunaan lahan seperti Taiwan, Cina dan Jepang. Data yang di gunakan pengamatan cuaca harian stasiun Meteorologi sekitar Jabota kurun waktu antara tahun 1980-2008 dibagi menjadi dua periode (periode 1980-1997 dan 1998- 2008) dan dibandingkan untuk mengetahui peningkatan suhu dan cuaca ekstrim. Data pengamatan udara atas periode tahun 1988-2008 dibagi menjadi dua periode dan dibandingkan untuk mengetahui peningkatan suhu udara atas pada lapisan tertentu. Data cuaca setiap jam antara tahun 2003-2008, stasiun Curug sebagai contoh untuk menganalisis pergeseran waktu kejadian suhu maksimum dan waktu terjadinya badai petir. Hasil analisis menunjukkan adanya peningkatan suhu rata-rata pada periode kedua, meningkatnya frekuensi suhu di atas 34°C, meningkatnya frekuensi curah hujan ekstrim pada bulanbulan tertentu terutama pada bulan di musim hujan dan transisi, meningkatnya frekuensi kejadian badai petir, meningkatnya rata-rata suhu udara atas terutama pada lapisan permukaan hingga 500mb, terjadi pergeseran waktu suhu maksimum pada bulan-bulan tertentu di musim kemarau dan transisi pada dari pukul 13.00 mejadi pukul 14.00 wib dan waktu kejadian badai petir tertinggi antara pukul 15.00-17.00 wib dan pukul 19.00-20.00 wib
Keyword: land us e changes, increase temperature, extreme weather

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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