Judul: Aktivitas antihiperglikemik dari ekstrak buah mahkota dewa [Phaleria macrocarpa (Scheff.) Boerl.] sebagai inhibitor alfa-glukosidase in vitro dan in vivo pada tikus putih
Abstrak: Alpha-glucosidase inhibitor is an oral antidiabetes for use in the management of type 2 diabetes mellitus. The antihyperglycemic activity of alpha-glucosidase inhibitor resulted from a competitive, reversible inhibition of hydrolase enzymes, pancreatic alpha-amylase and intestinal digestion enzymes (i.e., isomaltase, sucrase and maltase) which hydrolyzed dietary carbohydrates to glucose and other monosaccharides. In diabetic patients, inhibition of these enzymes result in a delayed glucose absorption and a lowering of postprandial hyperglycemia. The purpose of this research is to study the antihyperglycemic activity of the fruit extracts of Phaleria macrocarpa (Scheff) Boerl. as alpha glucosidase inhibitor by in vitro and in vivo experiments. The research is performed in several steps: fractionation and extraction of the ripe and unripe fruits, phytochemistry test of the fruit extracts, alpha-glucosidase inhibition test by in vitro experiment, toxicity test of the fruit extracts by using BSLT method and antihyperglycemic activity test by in vivo experiment with Oral Glucose Tolerance Test (OGTT) in the white rats. The alpha-glucosidase inhibition test in vitro is performed by using alphaglucosidase enzyme and substrate p-nitrophenyl α-D-glucopyranosa. The result of these experiment showed that n-butanol fraction extract of the ripe and unripe fruits have the highest activity followed by ethyl acetate fraction extract, methanol extract and water extract from the boiled of the ripe and unripe fruits. The water fraction extract of ripe and unripe fruits do not have any significant inhibition activity. Brine Shrimp Lethality Test (BSLT) method used the shrimp larvas of Artemia salina Leach to study the mortality effect that caused by the fruit extracts of phaleria macrocarpa. The data obtained was analyzed by using Sam’s method. Based on the LC50 value from the result of BSLT method, the unripe fruit extracts are more toxic than the ripe fruit extracts, with the highest toxicity is methanol extract followed by ethyl acetate fraction extract, boiled water extract and n-butanol fraction extract. In the antihyperglycemic activity test by in vivo experiment is used fifteen rats which are divided into three treatment groups: the positive control group which is given Acarbose drug, the treatment group which is given the water extract from the boiled ripe fruit and the treatment group which is given the n-butanol fraction extract of ripe fruit. The result of this experiment indicated that giving the water extract from the boiled ripe fruit with dose of 6.20 x 10-4 mg/ g rat and 1.24 x 10-3 mg/ g rat and the n-butanol fraction extract of ripe fruit with dose of 1.81 x 10-3 mg/ g rat and 3.62 x 10-3 mg/ g rat decreased the blood glucose concentration of rats after giving 80% w/v sucrose solution treated rats, that were comparable to those of Acarbose with dose of 1.00 x 10-3 mg/ g rat as the positive control. The conclusion of this research is the n-butanol fraction extract of the ripe and unripe fruits of Phaleria macrocarpa (Scheff) Boerl. have the highest antihyperglycemic activity by in vitro experiment to inhibition of alpha-glucosidase enzyme and by in vivo experiment in the white rats showed that antihyperglycemic activity from the n-butanol fraction extract of
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Judul: Potensi Antihiperglikemia Ekstrak Kulit Kayu Mahoni (Swietenia macrophylla King) pada Tikus yang Diinduksi Aloksan
Abstrak: Mahogany bark (Swietenia macrophylla King) contain active compound which have antihyperglycemic activity. This research was aimed at investigating the effect of mahogany bark on blood glucose concentration and histopathology in rat’s pancreas which induced alloxan. On this research Sprague-Dawley rats were divided into 5 groups, each group were 5 rats, A (NaCl 0.9% + aquades), B (aloxan + aquades), C (aloxan + Glibenclamide 0.25 mg/kg BW), D (aloxan + water extract of mahogany bark 250 mg/kg BW), and E (aloxan + metanol extract of mahogany bark 250 mg/kg BW). Blood glucose concentration defined by using Accu-Chek® Active glucometer. Pancreas histopathology analysis was carried out with Haematoxylin Eosin (HE) staining and observed under light microscope. Result showed water extract of mahogany bark can decrease blood glucose concentration from 173,2 mg/dL to 94 mg/dL (45,73%) and methanol extract of mahogany bark can decrease blood glucose concentration from 118,6 mg/dL to 88 mg/dL (25,80%). Result of histopathology showed there was improvement on pancreas gland. Methanol extract given better restoration effect on the islets of Langerhans than water extract
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Judul: Heisenberg Uncertainty of Double SlitSystem Based on Budiyono-Rohrlich Quantum Statistics Model
Abstrak: Interpretasi kuantum dikembangkan untuk memaknai secara fisis dengan jelas bagaimana suatu dinamika pada sistem mikroskopis yang dijelaskan dengan teori-teori kuantum, seperti interpretasi Copenhagen yang mendeskripsikan sistem kuantum sebagai suatu keadaan yang dideskripsikan dengan fungsi gelombang yang berisikan bagaimana peluang keadaan suatu sistem. Interpretasi kuantum juga bisa dibawa dari suatu sistem klasik seperti pada model statistika-kuantum Budiyono-Rohrlich yang menjelaskan bagaimana dinamika kuantum berhubungan dengan sistem klasik dengan penerapan statistika pada model Hamiltonian sistem. Fungsi distribusi dapat mendeskripsikan bagaimana suatu sistem terdistribusi pada suatu ruang pada pandangan klasik namun untuk sistem kuantum fungsi distribusi adalah peluang dari sistem tersebut. Sistem klasik dan kuantum juga dipisahkan berdasarkan pada ketidakpastian Heisenberg tentang suatu pengukuran yang tidak bisa secara sekaligus dilakukan bersamaan. Model statistika-kuantum Budiyono-Rohrlich membawa suatu sistem klasik menjadi sistem kuantum dengan dua aksioma yaitu hukum kekekalan energi rata rata dan konservasi rapat probabilitas. Sistem klasik yang didefinisikan akan diatur dengan menambahkan dua variable matematis berupa ontic extensions dan epistemic restrictions dimana kedua variabel ini yang akan menghubungkan bagaimana sistem klasik bisa diubah menjadi sebuah sistem kuantum. Dua variabel matematis tadi membuat sebuah sistem bisa diperlihatkan ketidakpastiannya lewat perhitungan simpangan rata-rata dan hasilnya akan selalu memenuhi ketidakpastian Heisenberg
Keyword: fungsi distribusi, model Budiyono-Rohrlich, ontic extension, epistemic restriction, ketidakpastian Heisenberg