Judul: The effect of virgin coconut oil (VCO) on the profile of immunohistochemical antioxidant superoxide dismutase (SOD) in the kidney of diabetes mellitus rat.
Abstrak: The aim of this research is to evaluate the effect of virgin coconut oil (VCO) on the profile of copper zinc-superoxide dismutase (Cu,Zn-SOD) in the kidney tissue of rats. A total of 25 male white rats (Rattus novergicus), Sprague Dawley were used for this study. They were divided into 5 groups ; (1) negative control group (K-), (2) positive control/diabetic rats group which was orally treated with aquadest (K+), (3) diabetic rats treated with VCO A (VA), (4) diabetic rats treated with VCO B (VB), (5) diabetic rats treated with coconut oil (MG). Diabetic condition was achieved by alloxan injection (IP, 110 mg/kgBW). The dose of aquadest, VCO, and coconut oil was 5ml/rat/day. The treatment were done for 28 days. The kidney were obtained at the end of treatment and then processed using paraffin embedding standard methods. The tissue were then stained with Hematoxillin-Eosin and immunohistochemical technique for Cu,Zn-SOD. The kidney tissues of diabetic rats group treated with VCO showed better morphological feature and higher content of Cu,Zn-SOD compared to that of diabetic rats group treated with aquades only or coconut oil. The treatment of VCO A gave better effect on the profile of antioxidant Cu,Zn-SOD compared to VCO B. Key words : Virgin coconut oil, diabetes mellitus, superoxide dismutase (SOD), kidney, rat
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Judul: Pengaruh Proses Pembuatan Virgin Coconut Oil (VCO) Terhadap Aktivitasnya sebagai Penurun Kadar Glukosa Darah pada Tikus Diabetes Melitus
Abstrak: Virgin Coconut Oil (VCO) has been produced nationally or internationally in various processing methods. Each of the processing method has claimed its own excellence, especially on its lauric acid content that found highest in VCO product. Based on that point of view, the research was conducted with the objective to study the effect of various processing methods in producing VCO on the bioactive compound of saturated medium chain fatty acids (MCFA, C8-C12) activities in reducing blood glucose of the diabetes mellitus (DM) rats. On the research used the Sprague Dawley white male rats. The rats were cared and grouped into healthy rats and DM rats. The DM rats achieved by adapting the rats for six days, followed for one night without giving any feeding prior to intraperitoneal way induction by using 110 mg alloxan solution per kg rats’ weight. After two days the content of rats blood glucose were then to be checked. The rats suffered DM if they had glucose content more than 200mg/dL. VCO produced without applying heat, VCO produced by applying controlled heat, also coconut cooking oil as a coconut oil which applied severe heat and chemically produced, were then given forcibly as medicine to each 5 DM rats. Meanwhile as a control, we made a group of positive control that suffered DM and a negative control as another health group (did not suffer DM). The two groups of control were not given the VCO or coconut cooking oil, but they were given drinking water. Each of the 5 groups of the rats were then observed during 28 days on the developing of the body’s rats weight at every two days, the amount of feed consumed at every day, blood glucose content at every 4 days, and at the end of the observing on the 29th day all of the rats were then terminated to be analyzed of theirs cholesterol level. Based on chemical analysis it was recognized that the content of fatty acid on two kinds of VCOs and coconut cooking oil is relatively no different. The content of lauric acid on VCO without heating was 51.5%, and on controlled heating VCO was 51.0% while on coconut cooking oil was 49.8%. Method of VCO processing, did not give significantly difference on the panelist preferences. It was statistically measured that either coconut cooking oil or VCO gave no significantly difference impact on the increasing of weight rats being experimented. The method of processing VCO and coconut cooking oil did not have significant impact on level 5% toward the percentage of blood glucose value on rats suffering DM. VCO without heating has tightly negative correlation on reducing glucose content. VCO did not give any impact at level 5% on total cholesterol content, HDL, LDL and triglyceride on rats’ blood serum suffering from DM.
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Judul: Formulasi Hamiltonian untuk Menggambarkan Gerak Gelombang Soliter Dimensi Tiga di Permukaan Laut
Abstrak: Gelombang permukaan adalah gelombang yang terjadi perbedaan rapat massa antara air dan udara. Salah satu gelombang permukaan yang ditinjau adalah gelombang soliter. Formulasi gelombang soliter dilakukan dengan menggunakan formulasi Hamiltonian.
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