Judul: Identification of ADAM17 Gene Expression as  Alzheimer’s Disease Marker in Long-Tailed Monkey (Macaca fascicularis) Brain
Abstrak: Penyakit Alzheimer adalah penyakit degeneratif otak yang mengganggu fungsi dasar neuron, sehingga dapat berujung kematian pada penderita yang kemampuan motoriknya tidak lagi berfungsi. Pengobatan spesifik untuk menangani penderita penyakit Alzheimer belum ditemukan. Masih terdapat banyak pertanyaan mengenai penyakit dan pengobatan penyakit Alzheimer. Salah satu metode yang digunakan untuk mengenal lebih dalam tentang penyakit ini adalah dengan menggunakan hewan model. Monyet ekor panjang merupakan primata yang memiliki kedekatan filogeni dengan manusia. Monyet ekor panjang tua juga memiliki karakteristik yang sama dengan manusia yang mengidap penyakit Alzheimer. Penelitian ini bertujuan mengidentifikasi ekspresi gen a disintegrin and metalloproteinase 17 (ADAM17) sebagai marka penyakit Alzheimer pada monyet ekor panjang. Penelitian ini menggunakan 6 sampel otak monyet ekor panjang bagian hipokampus dan korteks. Monyet sebelumnya telah dikelompokkan menjadi kelompok usia tua dan muda. Deteksi ekspresi gen ADAM17 dilakukan dengan menggunakan RT-qPCR. Hasil analisis data menunjukkan tidak berbeda nyata antara ekspresi gen ADAM17 pada tiap regio dan kelompok usia, namun didapatkan hasil bahwa ekspresi gen ADAM17 banyak ditemukan pada hewan tua dan regio hipokampus., Alzheimer's disease is a neurodegenerative disease that disrupts the basic functions of the neurons, potentially leading patients to death. There is no specific treatment for Alzheimer's disease. There are still many questions about Alzheimer's disease and its treatment. One of the methods often used to get to know more about this disease is to use animal models. The long-tailed monkey is a primate that has a phylogenetic closeness to humans. Aged long-tailed monkeys also have the same characteristics as humans with Alzheimer's disease. This study aimed to identify a disintegrin and metalloproteinase 17 (ADAM17) gene expression as a marker of Alzheimer's disease in long-tailed monkeys. This study used 6 brain samples of long-tailed monkeys in the hippocampus and cortex. Monkeys have previously been grouped into old and young age groups. The detection of ADAM17 gene expression was performed using RT-qPCR. The results of data analysis showed that there was no significant difference between ADAM17 gene expression in each region and age group, but the results showed that ADAM17 gene expression was mostly found in old monkeys and the hippocampus region.
Keyword: ADAM17, Hippocampus, Cortex, Long-tailed monkey, Alzheimer’s  disease

Judul: Characterization of ADAM10 gene as the Molecular Marker of Alzheimer on Cynolmogus Monkey’s Brain
Abstrak: Demensia merupakan gangguan pada memori, kemampuan kognitif dan perilaku. Terdapat 47 juta kasus di tahun 2015 dengan biaya penanganan yang mencapai 818 milyar Dollar Amerika Serikat secara global. Alzheimer merupakan penyumbang kasus demensia terbesar sehingga diperlukan pemahaman secara molekuler yang lebih mendalam untuk mempermudah mengatasi penyakit ini. Monyet ekor panjang yang memiliki kemiripan dengan manusia dipilih sebagai hewan model. Penelitian ini bertujuan untuk memahami lebih dalam mengenai ekspresi gen ADAM10 di otak serta potensinya sebagai marka molekuler penyakit Alzheimer. Sampel diekstrasi dari hipokampus dan korteks 9 ekor monyet betina. Pendeteksian level ekspresi mRNA ADAM10 di otak dilakukan dengan RT-qPCR. Hasil menunjukkan tidak ada beda nyata antara ekspresi mRNA ADAM10 pada kelompok Tua dan Dewasa serta pada regio hipokampus dan regio korteks. Namun, hasil perhitungan menujukkan kecenderung lebih tinggi pada monyet dari kelompok Tua dibanding kelompok Dewasa dan cenderung lebih tinggi di hipokampus daripada korteks dari seluruh sampel. Level ekspresi mRNA ADAM10 dianggap tetap berpotensi menjadi marka molekuler penyakit Alzheimer., Dementia is an impairment found in memory, cognitive functions, and behavior. There were 47 million cases of dementia and the treatment cost 818 billion USD globally in 2015. Alzheimer’s diseade (AD) is the biggest cause of dementia, thus it is important to have deeper understanding in molecular level to be able to treat this disease. Cynomolgus monkey were chosen because of the similarities between them with human. This study aimed to have more understanding about ADAM10 gene expression in the brain and its potential as molecular marker of Alzheimer’s disease. Samples were extracted from hippocampus and cortex of the brain of each 9 female monkeys. The detection of ADAM10 mRNA expression level was done using the RT-qPCR method. The results showed no significant differences in the expression between Old group and Adult group and also between hippocampus and cortex. However, the expression level tended to be higher in the Old group and the hippocampus. ADAM10 mRNA expression level is still considered as the potential molecular marker for AD.
Keyword: ADAM10, Alzheimer disease, cynomolgus monkey, RT-qPCR

Judul: Elektrodeposisi Film Tipis Semikonduktor Cu2ZnSnS4 (CZTS) pada Substrat Kaca ITO
Abstrak: Semiconductor Cu2ZnSnS4 (CZTS) thin film that can be used as absorber layers on solar cell module was made via electrodeposition method. CZTS thin film was electrodeposited on the surface of a silicate glass coated with a thin layer of indium tin oxide (ITO). Deposition process was done using potentiostatic mode at room temperature with a potential of 1.05 V for 30, 45, and 60 minutes, followed with annealing the film at 2 different temperatures, 500 ºC using furnace and 180 ºC using hot plate, both treatments for 45 minutes in N2/H2S atmosphere. The X-ray difractograms were analyzed using Match 2 program and showed that the CZTS thin films had kesterit crystalline structure, with a low percentage of CZTS phase. The thin film also contained secondary phases such as Cu2S, ZnS, and SnS. The obtained CZTS thin films had a thickness between 1.039 and 1.676 μm. Absorption study showed that the band gap energy of CZTS thin films which was annealed using furnace ranged from 1.50 to 1.52 eV, whereas that annealed using the hot plate was not observed. The band gap energy value showed that CZTS thin films can be used as sunlight absorber layers on solar cell. The formation of CZTS crystal film on this investigation was effectively performed using furnace annealing process at a temperature of 500 ºC with deposition time of 45 minutes.
Keyword: Thin film, Electrodeposition, Cu2ZnSnS4