Judul: Dinamika Penggunaan Lahan dan Penataan Ruang Kabupaten Bekasi
Abstrak: Bekasi Regency is a strategic area since it shares borders with Jakarta. This gives the inhabitants opportunities directly or indirectly to Jakarta’s economic power. The rapid development implies soaring requirements of space to assist various utilizations such as governmental uses, trade/commercials, services and industry. In Bekasi case, the development has been aided by availability of existing facilities, including road infrastructures. The aims of this research are to assess the dynamics of population and economic growth, spatial arrangement and their relationships to land use changes in Bekasi regency between 1995 and 2009. Methods to achieve the goal include remotely sensed image processing and statistical inquiries which consist of correlation and stepwise regession analysis. This research revealed that main land use alteration involves upland and rice fields and is largely converted to residential, industrial area or other services. Nonetheless, overall changes are insignificant during 15 year of observation. However, it is shown that land use modification tends to occur locally or clustered along Tambun, Cibitung and Cikarang zones, in particular between 2000 and 2006. During 2006-2009 period, the changes spreaded across the residency, except Bojongmangu district. It was found that the main driving factors influencing land alteration in Bekasi Regency are accessibility to road networks, rapidly-growing population, expanding facilities development and space allocation.
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Judul: Spatial Quantitative Analysis of Land Cover Changes and Regional Development Index in Bekasi City
Abstrak: Kawasan perkotaan merupakan suatu wilayah dengan kepadatan penduduk yang diikuti dengan intensitas pemanfaatan ruang terbangun yang tinggi. Perkembangan suatu wilayah perlu dianalisis lebih lanjut untuk mengetahui tingkat pertumbuhan wilayah dalam berbagai sektor dan urgensi kebutuhan ruang yang semakin terbatas. Kota Bekasi merupakan kota dengan perkembangan wilayah yang tinggi pada Provinsi Jawa Barat. Melihat dari kondisi ini, wilayah penelitian memiliki potensi besar untuk terjadi konversi lahan yang menyebabkan ketersediaan lahan di Kota Bekasi menurun. Tujuan penelitian ini untuk mengetahui pola perubahan tutupan lahan, tingkat perkembangan wilayah, serta faktor-faktor yang memengaruhi perkembangan wilayah. Metode yang digunakan pada analisis perubahan tutupan lahan, yaitu analisis overlay, sedangkan pada tingkat perkembangan wilayah digunakan metode analisis skalogram untuk menentukan Indeks Perkembangan Kelurahan (IPK). Metode yang digunakan pada analisis perkembangan wilayah penelitian yaitu Geographically Weighted Regression (GWR). Hasil penelitian menunjukkan Kota Bekasi dalam 10 tahun terakhir (2011- 2021) mengalami peningkatan lahan terbangun sebesar 6,39%, sedangkan pada pertanian lahan kering menurun sebesar 5,80%. Pada Kota Bekasi kelurahan yang mengalami peningkatan nilai IPK tertinggi sebesar 27,93 pada tahun 2011 dan 31,43 pada tahun 2021. Berdasarkan hasil analisis GWR lokasi perkembangan wilayah di Kota Bekasi, nilai Local R-Square pada tahun 2011 berkisar 0,105179- 0,539471 dan pada tahun 2021 berkisar 0,265871-0,506559. Lahan terbangun berpengaruh positif pada perkembangan wilayah, tetapi keberadaan pertanian lahan kering berpengaruh negatif. Sehingga semakin tinggi jumlah fasilitas pada suatu wilayah, maka semakin berpengaruh terhadap perkembangan wilayahnya.
Keyword: geographically weighted regression, land cover change pattern, regional development level, urban development index

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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