Judul: Potensi fraksi air buah makasar (Brucea javanica (L.) Merr) terhadap gambaran histopatologi pankreas tikus yang diinduksi aloksan
Abstrak: Brucea fruit (Brucea javanica (L.) Merr) is one of Indonesian medicine plants which rich in advantages. Empirically, brucea fruit can decrease blood glucose concentration for patient of diabetes mellitus. This research was aimed to determine the effect of aqueous fraction from ethanolic extract of brucea fruit on histopathological in rat pancreas which induced alloxsan. On this research Sprague Dawley rats were divided into 6 groups, each group were 4 rats, group A (Normal), B (alloxan + Glibenclamide 0.25 mg/kg BB), C (alloxan + aquades), D (alloxan + Brucea fruit water fraction 0.25 mg/kg BB), E (alloxan + Brucea fruit water fraction 25 mg/kg BB), dan F (alloxan + Brucea fruit water fraction 50 mg/kg BB). Pancreas histopathological analysis was carried out with Haematoxylin-eosin (HE) staining and observed under light microscope. Reserch showed that aqueous fraction from ethanolic extract of brucea fruit dosage 0.25 mg/kg BB, 25 mg/kg BB, and 50 mg/kg BB can repair the damage of rat pancreas which induced alloxan 150 mg/kg BB. Aqueous fraction from ethanolic extract of brucea fruit dosage 50 mg/kg BB given better restoration effect on the islets of Langerhans than Glibenclamide.
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Judul: Aktivitas antihiperglikemia fraksi air buah makasar (Brucea javanica (L.) Merr) pada tikus yang diinduksi aloksan
Abstrak: Brucea fruit (Brucea javanica (L.) Merr) was known to have a potential antidiabetic activity. This research was aimed to determine antihyperglycemic activity of aqueous fraction from ethanolic extract of brucea fruit in alloxan induced rats. Aqueous fraction of ethanolic extract brucea fruit obtained by maseration using ethanol 95%, which then separated using funnel separator with mixed solution of hexane, methanol, and water (5:9:1) and chloroform:water (1:1). Twenty four rats divided into 6 groups. In the process of raising the blood glucose concentration, one of normal group induced by NaCl 0.9% and the other five treatment groups induced by alloxan (150 mg/kg BW). Afterwards, in the treatment process, normal group and negative control administered by aquadest, positive control administered by glibenclamid (0.25 mg/kg BW), and three other groups administered by aqueous fraction of ethanolic extract brucea fruit in dosage 0.25, 25, and 50 mg/kg BW. Blood glucose concentration of the fasting rats measured at day 0, 3,7,11, and 15. Aqueous fraction from ethanolic extract of brucea fruit contained 3.71% in yield. The result showed that aqueous fraction from ethanolic extract of brucea fruit in dosage 0.25, 25, dan 50 mg/kg BW decreased the blood glucose concentration as many 37.64%, 37.43%, and 60.82% respectively. Aqueous fraction of brucea fruit wich is extracted by ethanol in dosage 50 mg/kg BW has higher activity than glibenclamid in dosage 0.25 mg/kg BW (45.53%).
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Judul: Hamiltonian formulation for linear waves motion in two layers fluid
Abstrak: The surface wave could be considered as a wave that separates two fluids, namely water and air. Based on this assumption, it is introduced the interfacial wave, a wave between two layers of fluid with different density. The formulation of interfacial waves motion begins with deriving the base equation of irrotational ideal fluid. Furthermore, according to irrotational fluid assumption, the base equation can be stated in velocity potential. In this derivation, the fluids domain is assumed to be restricted by rigid lid boundary conditions, both at the upper and lower limit. Therefore, the interfacial waves motion can be explained in a hamiltonian formulation. In the hamiltonian formulation, total energy is defined as the sum of kinetic and potential energy. The hamiltonian system is obtained from reduction of kinetic energy by using the Dirichlet Neumann Operator. The resulted kinetic energy equation is nonlinear. Therefore, this form is linearized by first part of the Taylor expansion. This linearization gives a dispersion relation of linear wave. Based on this dispersion relation, the phase speed of the linear wave depends on the density ratio of the two layers fluid.
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