Judul: Total Fenolik,  Flavonoid, dan Inhibisi Lipase Pankreas Ekstrak Kulit Buah Nangka (Artocarpus  Heterophyllus Lam.)
Abstrak: Obesitas berhubungan dengan penumpukan lemak di dalam tubuh disimpan dalam bentuk trigliserida. Obesitas dapat dicegah dengan menginhibisi enzim lipase menggunakan senyawa yang berasal dari golongan flavonoid dan fenolik. Kulit buah nangka diketahui memiliki kandungan total fenolik empat kali lebih banyak dibandingkan dengan bagian biji dan daging buah. Oleh karena itu, potensi ekstrak kulit buah nangka sebagai inhibitor lipase perlu dikaji lebih lanjut. Penelitian ini bertujuan menentukan kadar total fenolik, kadar total flavonoid, serta daya inhibisi lipase pankreas oleh ekstrak kulit buah nangka dewasa dan muda secara in vitro. Metode yang digunakan pada penelitian ini yaitu ekstraksi, analisis total fenolik dan flavonoid, serta uji inhibisi lipase. Hasil penelitian menunjukkan bahwa kulit buah nangka muda memiliki total fenolik dan flavonoid serta persen inhibisi lipase yang lebih tinggi dibandinkan kulit buah nangka dewasa, yaitu berturut-turut sebesar 242,50 ± 5,20 mg EAG/g bobot kering, 19,59 ± 0,09 mg EK/g bobot kering, dan 47,81 ± 1,79%. Berdasarkan penelitian yang telah dilakukan, kulit buah nangka muda lebih potensial sebagai kandidat inhibitor lipase pankreas., Obesity is related to the accumulation of fat in the body stored as triglycerides. Obesity can be prevented by inhibiting the lipase enzyme using the compounds from the phenolic and flavonoid groups. Jackfruit peel extract known to have total phenolic and flavonoid four times higher than the seed and pulp part. Therefore, the potential of jackfruit peel extract as pancreatic lipase inhibitor sould be studied further. This research aimed to determine the total phenolic, total flavonoid, and pancreatic lipase inhibition by young and mature jackfruit peel extract in vitro. The methods that has been used in this research are extraction, total phenolic content determination, total flavonoid content determination, and pancreatic lipase inhibition. The result of this research shows that young jackfruit peel extract has higher total phenolic content, total flavonoid content, and pancreatic lipase inhibition than mature jackfruit peel extract with the value of 242,50 ± 5,20 mg GAE/g dry weight, 19,59 ± 0,09 mg QE/g dry weight, and 47,81 ± 1,79% respectively. Based on the research that has been conducted, young jackfruit peel has more potential as pancreatic lipase inhibitor than mature jackfruit peel.
Keyword: flavonoid, jackfruit, lipase, obesity, phenolic

Judul: Antioxidant Capacity and  Pancreatic Lipase Inhibition Assays Fractionation of Guava Leaves (Psidium  guajava) In Vitro
Abstrak: Obesity is an overweight condition that is still a problem around the world. Guava (Psidium guajava) is a plant that has potential as an antiobesity because contain phenolics, flavonoids, and antioxidant that are thought to prevent obesity through inhibition of pancreatic lipase. The purpose of this study was to determine the antioxidant capacity, total phenolic and flavonoid content, and inhibitory activity of crude extracts and fractions of guava leaves against pancreatic lipase. The method used was extraction by sonication and then fractionation using n-hexane, chlorophom, ethyl acetate, and water. The fractionation results were tested for total phenolic and flavonoid content, antioxidant capacity with DPPH (1,1-diphenyl-2-picryl-hydrazyl) and FRAP (Ferric Reducing Antioxidant Power) methods, and inhibition activity against pancreatic lipase. The results showed that the highest levels of total phenolics, total flavonoids, and antioxidant capacity by DPPH method were found in the water fraction. The highest percent inhibition value was in the crude extract and water fraction of 91,04% and 93,45%., Obesitas merupakan keadaan berat badan berlebih yang masih menjadi masalah yang terus berkembang di seluruh dunia. Jambu biji (Psidium guajava) merupakan tanaman yang berpotensi sebagai antiobesitas karena mengandung fenolik, flavonoid, dan antioksidan yang diduga dapat mencegah obesitas melalui penghambatan lipase pankreas. Tujuan penelitian ini adalah menentukan kapasitas antioksidan, kadar fenolik dan flavonoid total, serta aktivitas inhibisi ekstrak kasar dan fraksi daun jambu biji terhadap lipase pankreas. Metode yang digunakan yaitu ekstraksi dengan sonikasi kemudian difraksinasi bertingkat menggunakan n-heksana, klorofom, etil asetat, dan air. Hasil fraksinasi diuji kadar fenolik dan flavonoid total, kapasitas antioksidan dengan motode DPPH (1,1-diphenyl-2-picryl-hydrazyl) dan FRAP (Ferric Reducing Antioxidant Power), serta aktivitas inhibisi terhadap lipase pankreas. Hasil penelitian menunjukkan bahwa kadar fenolik total, flavonoid total, dan kapasitas antioksidan dengan metode DPPH tertinggi ditemukan pada fraksi air. Nilai persen inhibisi terhadap lipase pankreas tertinggi yaitu pada ekstrak kasar dan fraksi air sebesar 91,04% dan 93,45%.
Keyword: Antiobesitas, Lipase Pankreas, Psidium guajava, Anti-obesity, Pancreatic lipase, Daun jambu biji

Judul: Implementation of Spatio-Temporal Change Query in Relational Database.
Abstrak: Geographic object changes in various views. Object changes are recorded using a model of static storage. No historical connection between old version data and new version data has been built. For that, a storage model of spatio-temporal queries that can analyze spatio-temporal changes has been developed. The object changes the geometry are grouped according to the taxonomy of Spatio-Temporal Pattern Change. This research has been able to apply the query patterns change including born, expand, merge, contract, split, normal and die. This query based on geometric (area) changes. The implementation of spatio-temporal change queries represents an object changes continuously with easy, change detection is done by comparing two versions of data. Keyword: spatio-temporal change query, spatio-temporal change pattern.
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