Judul: Redesign of Taman Malabar as Therapeutic Garden for Children with autism in Bogor City
Abstrak: Autisme adalah gangguan perkembangan yang berdampak pada hambatan bersosialisasi, berkomunikasi, dan juga berperilaku. Jumlah pengidap autisme di dunia terus meningkat setiap tahun, namun pada kenyataannya jumlah fasilitas terapi yang ada saat ini masih kurang untuk mengatasi jumlah penderita autisme yang terus bertambah. Kegiatan terapi yang ada saat ini lebih terfokus pada obatobatan serta dilakukan dalam ruangan seperti fasilitas perawatan atau medical center, sedangkan fasilitas terapi disarankan untuk menggunakan pendekatan dengan alam sehingga dapat lebih cepat dalam proses pemulihan. Dalam rangka mendukung peran Kota Bogor sebagai kota ramah anak berkebutuhan khusus, Taman Malabar yang terletak di kota Bogor dapat digunakan sebagai ruang terapi untuk anak autis. Lokasi Taman Malabar berada di pusat kota dikelilingi dengan fasilitas seperti bangunan kesehatan, bangunan pendidikan termasuk Sekolah Luar Biasa, serta bangunan lain di sekitarnya, menjadikan Taman Malabar berpotensi sebagai taman terapi yang dapat memberikan fungsi penyembuhan serta fungsi umum lainnya. Tujuan dari penelitian ini adalah untuk mengidentifikasi dan menganalisis kebutuhan anak autis terhadap taman terapi yang sesuai dari sisi psikologisnya serta membuat konsep dan desain taman terapi yang sesuai dan baik secara fungsi ataupun visual untuk anak autis. Konsep dasar dari penelitian ini merupakan rekomendasi desain taman sensori untuk anak autis yang dirancang sesuai untuk kebutuhan anak hipersensitif dan anak hiposensitif dengan menerapkan konsep desain berupa kombinasi dari pola organik dan geometrik. Produk yang dihasilkan dari penelitian ini berupa site plan, gambar potongan, gambar perspektif, dan DED., Autism is a developmental disorder that has an impact on barriers to socializing, communicating, and behaving. The number of people with autism in the world continues to increase every year, but the number of existing therapy facilities is still insufficient. Current therapy activities are mostly focused on medicine and are carried out indoor using treatment facilities or medical centers, while therapy method is suggested to use natural approach as perceived that the recovery process could be faster. To support the role of Bogor City as a childfriendly city with special needs, Malabar Community Park is proposed to be a therapy garden for children with autism. The location of Malabar Community Park is in the city center surrounded by facilities such as hospital buildings, education buildings including the special needs school, and other buildings in the vicinity, making Malabar Community Park has a opportunity to be designed as a therapy park. The purpose of this study are to identify and to analyze the needs of children with autism for a suitable therapeutic garden from a psychological point of view, and to create a concept and to design therapeutic garden that is appropriate functionally and visually for children with autism The basic concept of this research is a recommendation for designing a sensory garden for autistic children which is designed according to the needs of hypersensitive and hyposensitive children by applying a design concept in the form of a combination of organic and geometric patterns. The products produced from this research are in the form of site plans, cut-out images, perspective images, and DED.
Keyword: Design Landscape, Therapeutic Garden, Autism Children

Judul: Therapeutic Garden Design to Support Psychosocial Rehabilitation at Marzoeki Mahdi Hospital
Abstrak: Orang Dengan Gangguan Jiwa merupakan kondisi penyakit mental berupa gangguan pada pikiran, perilaku juga perasaan yang terlihat pada perubahan perilaku signifikan. Rumah Sakit dr. H. Marzoeki Mahdi (RSMM) merupakan salah satu rumah sakit jiwa yang memberi pelayanan Rehabilitasi Psikososial. Rehabilitasi Psikososial terdiri dari berbagai macam kegiatan untuk mengasah kemampuan pasien sehingga dapat kembali hidup bermasyarakat. Salah satu kegiatan yang dilakukan yaitu berkebun. Taman menjadi kebutuhan dalam proses rehabilitasi, sehingga dibutuhkan desain agar kondisi taman mampu memenuhi kebutuhan rehabilitasi. Tujuan penelitian ini yaitu mengidentifikasi dan menganalisa aktivitas, kebutuhan pengguna dan kondisi serta potensi kendala yang terdapat pada tapak, menentukan konsep desain dan konsep pengembangan dan menyusun rekomendasi desain pengembangan taman. Penelitian ini menggunakan metode deskriptif dengan tahapan berupa persiapan, pengumpulan data, analisis dan sintesis, konsep serta desain. Data diambil melalui survei lapang, wawancara, kuesioner serta studi pustaka. Konsep dasar berupa taman terapi untuk mendukung Rehabilitasi Psikososial. Konsep desain menerapkan aktivitas utama pasien yaitu bersosialisasi, digambarkan dengan pola lingkaran dan berulang. Selain itu, diterapkan pula pola geometris yang menggambarkan keteraturan dan ketegasan. Berdasarkan pola tersebut, terbentuk ruang yaitu welcome area, area terapi aktif, area terapi pasif dan area parkir., People with Mental Disorders are a condition of mental illness. Rumah Sakit dr. H. Marzoeki Mahdi is one of the hospitals that provides Psychosocial Rehabilitation. Psychosocial Rehabilitation consists of various activities to hone the patient's abilities so they can return to social life. One of the activities carried out is gardening. The garden becomes a necessity in the rehabilitation process, a design is needed so the garden conditions are able to meet the rehabilitation needs. The purpose of this research is to identify and analyze activities, user needs and conditions as well as potential found on the site, determine the design concept and development concept and garden development design recommendations. This research uses a descriptive method such as preparation, data collection, analysis and synthesis, concept and design. Data was collected through field surveys, interviews, questionnaires and literature studies. The basic concept is a therapeutic garden to support Psychosocial Rehabilitation. The design concept applies to the patient's main activity of socializing, depicted with circular and repetitive patterns. In addition, geometric patterns are also applied which illustrate order and firmness. Based on this pattern, spaces are formed, namely the welcome area, active therapy area, passive therapy area and parking area.
Keyword: landscape design, mental disorders, psychosocial rehabilitation, therapeutic garden

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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