Judul: Acute Oral Toxicity Lethal
Dose 50 (LD50) of Cayenne Pepper (Capsicum annuum) Infusion in DDY Strain
Mice (Mus musculus)
Abstrak: In recent years, there has been a growing interest in herbal remedies such as cayenne pepper which is known for its versatility beyond its culinary use. Cayenne pepper’s phytochemicals, including capsaicinoids, carotenoids, phenolic compounds, vitamins, and minerals, offer antioxidant, antimicrobial, and antiinflammatory properties, making it a valuable ingredient in various fields such as veterinary medicine, agro-food, cosmetics, and pharmaceuticals. However, concerns regarding the potential risks of cayenne pepper consumption as herbal medicine arise. This study aims to determine the acute oral toxicity lethal dose 50 (LD50) of cayenne pepper infusion in female DDY strain mice and its effects on the mice's organs. The research involved 20 DDY strain female mice divided into 4 groups which are control group (administered with distilled water) and treatment groups that are given cayenne pepper infusion at doses of 5, 10, and 15 g/kg BW orally. The observed variables included mortality, clinical symptoms, physiological responses, and organ weight. Acute toxicity testing indicated that the cayenne pepper infusion falls into the category of practically non toxic formulations. Administration of the cayenne pepper infusion up to a dose of 15 g/kg BW did not induce toxicity symptoms, such as clinically pathological symptoms, macro anatomical organ changes, or mortality nor affect both weight gain and loss.
Keyword: cayenne pepper, infusion, acute oral toxicity, DDY strain mice, herbal medicine

Judul: Efektivitas Cabai Rawit (Capsicum annuum) terhadap  Efek Analgesik dan Stamina Mencit Jantan (Mus musculus)
Abstrak: Cayenne is used all over the world and is mostly used in cooking as a spice that is added to different dishes and sauces to give them flavour, colour, and perfume. Chilli peppers are a member of the genus Capsicum and has a compound found in chilli peppers that is active is called capsaicin (8-methyl-N-vanillyl-6 nonenamide). The term "fatigue" is frequently used and has multiple definitions, causal relationships, and domains. Capsaicin is a useful tool in the study of pain since it causes pain in addition to the feeling of heat. Mice's stamina can be increased by flavonoids through their inhibition of the phosphodiasterase enzyme, which is responsible for converting cAMP to AMP. This study determined the effectiveness of cayenne pepper (Capsicum annuum) on analgesic effect and stamina. The tail flick test was used to determine the analgesic effect of the treatment on mice. The swimming endurance test was used to determine the stamina of the mice. A total of 20 mice were used and divided into 4 treatment groups: control, 1, 2 and 4 mg/g BW. To determine the statistical significance of the data, ANOVA one-way and Tukey tests were conducted. Based on the statistical analysis, cayenne pepper was effective to increase stamina at 4 mg/g BW whereas cayenne pepper was effective to increase analgesic effect at 2 and 4 mg/g BW. In conclusion, cayenne pepper shows effects on both stamina and analgesic effect.
Keyword: analgesic effect, cayenne pepper, mice, stamina

Judul: Peranan Pesantren dalam Pembangunan Pedesaan
Abstrak: Pesantren (pondok atau pondok pesantren) adalah suatu lembaga pendidikan keagamaan Islam yang pada umumnya tumbuh di kalangan masyarakat pedesaan. Pertumbuhannya merupakan hasil refleksi pimpinan pesantren dan masyarakat terhadap kebutuhan masyarakat sekitar. Disamping sebagai lembaga pendidikan keagamaan, diharapkan pesantren dapat berperan sebagai lembaga sosial kemasyarakatan yang dapat membantu pemerintah dalam menyebar luaskan inovasi pembangunan kepada masyarakat, dan menggerakkan masyarakat agar berperan serta dalam pembangunan.
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