Judul: Performa Pertumbuhan dan Daya Tahan Ikan Nila Oreochromis niloticus F1 Hasil Seleksi Berbasis Marka MHC I terhadap Penyakit Streptococcosis
Abstrak: Streptococcosis, caused by the bacteria Streptococcus agalactiae, is a type of diseases that is often found in Nile tilapia farming. MHC I molecules are involved in immune system of vertebrate. This study was performed to evaluate the inheritance of the MHC I marker, the growth response and disease resistance of the first generation of Nile tilapia selected using marker assisted selection method and infected by S. agalactiae bacteria. First generation (F1) were produced by performing crossbreeds, namely: female and male having MHC I, female without MHC I x male having MHC I, female having MHC I x male having MHC I, and female and male without MHC I. MHC I marker inheritance in the progenies were identified, and challenged test was conducted by interperitoneally injecting of 0.1 mL S. agalactiae (107 CFU/mL) for 14 days. The inheritance of MHC I marker in F1 fish was relatively high level, ranging from 78.3-93.0%. Crossbreed of female and male without MHC I has 85.0% survival, highest than other treatments.
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Judul: Gene Expression and Blood Profiles of Nile Tilapia (Oreochromis niloticus) Resistant to Aeromonas hydrophila
Abstrak: Salah satu kendala yang sering terjadi dalam budidaya ikan nila adalah penyakit bakterial yang disebabkan oleh bakteri Aeromonas hydrophila. Usaha yang dapat dilakukan untuk mengurangi dampak infeksi bakteri patogen adalah dengan melakukan evaluasi respons imun secara molekuler. Penelitian ini bertujuan untuk mengevaluasi respons imun ikan nila (Oreochromis niloticus) terhadap infeksi bakteri A. hydrophila berdasarkan ekspresi gen mhc1, lisozim (lysc), dan interleukin (il1b) serta gambaran darah di jaringan hati ikan pascainfeksi. Perlakuan infeksi diberikan melalui penyuntikan ikan nila dengan 0,1 mL bakteri A. hydrophila dosis LD50 secara intramuskular, dan pada ikan kontrol dilakukan penyuntikan dengan 0,1 mL PBS. Selanjutnya dilakukan isolasi jaringan, analisis darah, ekstraksi RNA dan sintesis cDNA, serta analisis ekspresi gen. Hasil penelitian menunjukkan pada ikan yang diinfeksi A. hydrophila memiliki tingkat kelangsungan hidup sebesar 21,42%, sedangkan pada ikan kontrol tidak ditemukan kematian. Ekspresi gen mhc1,lysc dan il1b ikan nila resistan cenderung lebih tinggi daripada ikan nila yang rentan pascainfeksi A. hydrophila. Gambaran darah yang meliputi hematokrit, jumlah eritrosit, leukosit dan kadar hemoglobin pada ikan nila tahan infeksi (resistan) A. hydrophila menunjukkan kecenderungan lebih tinggi dibandingkan dengan ikan nila yang tidak tahan infeksi (rentan)., One of the obstacles that often occurs in tilapia cultivation is bacterial disease caused by the bacteria Aeromonas hydrophila. Efforts that can be made to reduce the impact of pathogenic bacterial infections include conducting a molecular evaluation of the immune response. This study aims to evaluate the immune response of tilapia (Oreochromis niloticus) to A. hydrophila infection based the expression of mhc1, lysozyme (lysc), and interleukin (il1b) genes and on blood profiles in the liver tissue after infection. Infection treatment was given by injecting tilapia fish with 0.1 mL of the LD50 dose of A. hydrophila bacteria intramuscularly, and control fish were injected with 0.1 mL of PBS. Then, tissue isolation, blood analysis, RNA extraction, cDNA synthesis, and gene expression analysis were carried out. The results of the study showed that fish infected with A. hydrophila had a survival rate of 21.42%, while no deaths were found in control fish. The expression of the mhc1, lysc, and il1b genes in resistant tilapia tended to be higher than in susceptible fish after A. hydrophila infection. Blood profiles including hematocrit, number of erythrocytes, leukocytes, and hemoglobin levels in resistant tilapia to A. hydrophila infection tends to have higher level compared to susceptible fish.
Keyword: Aeromonas hydrophila, Oreochromis niloticus, il1b, lysc

Judul: Metrik Einstein (Anti-) Self-Dual Berdimensi Empat dengan Metode Cartan
Abstrak: Gravitational field equation can be formulated in differential forms (differential geometry), which describes gravity as a manifestation of the curvature of space-time. Curvature of space-time is characterized by a metric that satisfies the gravitational field equation. With differential forms it can be formulated the (anti-) self-dual Einstein equation, which is a modification of the Cartan structure in (anti-) self-dual basis. Calculation of (anti-) self-dual metric with (anti-) self-dual Einstein equation is simpler than the calculation using Christoffel symbols.
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