Judul: Pengetahuan tentang manfaat kesehatan temulawak (Curcuma xanthorrhiza Roxb.) dan uji klinis minuman instan temulawak terhadap limfosit T, B, dan Sel NK pada obesitas
Abstrak: The objectives of the following study were to analyze the health benefit knowledge of curcuma on adult and clinical efficacy of curcuma instant drink to increasing lymphocytes count. Design for knowledge survey was cross sectional study and involving 79 subjects (40 male and 39 female) while the design for clinical trial was pre and post test design and involving 21 subjects. Result of this study showed that the health benefits of curcuma most widely known by subjects were to increase appetite (93.4%) and to maintain stamina (92.1%). Female subjects have higher knowledge (58.0 ± 25.8) than male subjects (57.0 ± 28.3) altough there isn’t significance difference (p > 0.05) and the knowledge of curcuma health benefit inversely with the level of education (p < 0.05). The study showed that there was significant increase (p = 0.034 and p = 0.045) in T cell population (CD3+, CD4+) and significant decreasing (p = 0.000 and p = 0.001) in B cell (CD 19+) and CD8+ after intervention of 13.24 g curcuma instant drink per day. It was concluded that curcuma has potential beneficial effect in enhancing cellular immunity but decreasing in humoral immunity in obese human subjects.
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Judul: Potensi Pelepah Temulawak (Curcuma xanthorriza) sebagai Antikanker dan Antioksidan
Abstrak: The study aimed to evaluate the potency of temulawak (Curcuma xanthorrhiza) stem as anticancer by brine shrimp lethality test (BSLT) and antioxidant by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays. The stem of temulawak midrib obtained from Bogor, was extracted by n-hexane, chloroform, ethyl acetate, methanol, and water, and the volatile oil was obtained by water distillation. The chloroform extract and volatile oil showed anticancer potency towards Artemia salina (LC50: 370.69 ± 22.69 μg mL-1 ; 123.05 ± 3.49 μg mL-1, respectively). Ethyl acetate and chloroform extracts had antioxidant activities (IC50: 46.41 ± 15.49 μg mL-1 and 52.72 ± 3.46 μg mL-1) but the activity did not as strong as ascorbic acid (control positive, IC50 1.80 ± 0.33 μg mL-1). The chloroform extract was further fractionated by column chromatography with Silica Gel G60F254-Merck as stationary phase and gradient of n-hexane, chloroform, and methanol as mobile phase. Antioxidant and anticancer potency of fraction which had antioxidant activity qualitatively were tested. The most antioxidant active fraction (F9) had anticancer potency (LC50: 522.95 ± 43.35 μg mL-1) and antioxidant activity (IC50: 79.57 ± 8.96 μg mL-1). In conclusion, F9 is potencial as an anticancer and antioxidant.
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Judul: Rancang Bangun Mekanisme Penggetar Untuk Bajak Subsoil Getar Dengan Dua Bilah Bajak
Abstrak: Bajak subsoil merupakan alat pengolahan tanah pertama yang sering digunakan sebelum pembajakan dengan bajak singkal atau bajak piring untuk memecah lapisan keras di lapisan bawah. Alat ini biasanya digunakan pada tanah yang telah mengalamli pemadatan akibat lalu lintas traktor. Alat ini memiliki tahanan tarik yang tinggi dan biasa ditarik traktor empat roda
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