Judul: Myoglobin content of cobalt chloride hexahydrate- induced acute hypoxia in the rat (Rattus norvegicus)
Abstrak: Cobalt is one of the bone and joint implant material. As cobalt has toxicity properties the aim of this research is to prove an increase of percent myoglobin/ protein ratio in heart, liver and muscle of cobalt chloride hexahydrate-induced acute hypoxia rats. The rats were intraperitoneally injected by 1 mL syringe with 6 and 16 mg/kg for first 3 days. Then after the 3rd day the rats were subjeted to physiological adaptation phase for each group up to day 10 and 14. The measured parameters include rat body weight change, organ water content, myoglobin per protein percentage, organ cobalt content and blood glucose level. Both protein and myoglobin content were measured using UV Vis spectrophotometer at 280 and 503 nmm blood glucose level was measured on 550 nm. Cobalt content was measured using AAS at 240.7 nm. All treated rats indicated significant weight loss at change 2 (3rd day of injection) and weight gain at change 3 (day 4). Duncan significance test, only rat muscle indicated significant difference based on dose. All organs did not differ significantly in relation to both dose and day. Both liver and heart accumulated cobalt ion and indicated a reduction state on day 14th . The glucose level in all treated group of day 10 was higher than control
Keyword: Cobalt, Glucose level, Hypoxia, Myoglobin, Rat weight, Protein preentage, Organ cobalt content, Blood glucose level, Organ water content, Ratio between myoglobin, Protein, Organ cobalt content, Blood glucose level

Judul: Profil Hematologi Mencit pada Implantasi Biomaterial Logam Berbahan Dasar Besi
Abstrak: Biomaterials are certain materials that are inserted into the body and used as a medical device that interacts with the body's tissues and fluids. The aim of this study was to determine the effect of implantation of iron based metal biomaterials to blood hematological profile, including the erythrocyte count, hemoglobin concentration, hematocrit value, leukocyte count and leukocyte differentiation. This study used 40 mice. The mice were divided into 4 groups, the iron wire group (Fe, n = 12), chromium-coated iron wire (Fe-Cr, n = 12), stainless steel surgical wire (316L SS, n = 12) and the control group (n = 4). Mice implanted with metal biomaterials in the hip area subcutaneously and in thigh area intramuscularly. Blood sampling performed on days 0, 1, 4, and 14 after implantation of biomaterials, through the retro-orbital sinus using microhematocrit tube. Implantation of iron based metal biomaterial not caused significant changes to erythrocytes count, hemoglobin levels, hematocrit values lymphocytes, eosinophils, and basophils. Leukocyte count, percentage of neutrophils, and percentage of monocytes in all groups of mice were significantly increased on day 1 (p<0.05), but on days 0, 4, and 14 showed the values that are not significantly different (p> 0.05). Generally, the implantation of iron based metal biomaterial not caused significant changes to red blood cell and white blood cell’s profiles.
Keyword: subcutaneously, mice, iron based metal implant, intramuscularly, hematology

Judul: Peranan Pesantren dalam Pembangunan Pedesaan
Abstrak: Pesantren (pondok atau pondok pesantren) adalah suatu lembaga pendidikan keagamaan Islam yang pada umumnya tumbuh di kalangan masyarakat pedesaan. Pertumbuhannya merupakan hasil refleksi pimpinan pesantren dan masyarakat terhadap kebutuhan masyarakat sekitar. Disamping sebagai lembaga pendidikan keagamaan, diharapkan pesantren dapat berperan sebagai lembaga sosial kemasyarakatan yang dapat membantu pemerintah dalam menyebar luaskan inovasi pembangunan kepada masyarakat, dan menggerakkan masyarakat agar berperan serta dalam pembangunan.
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