Judul: Aktivitas Hepatoprotektor dan Toksisitas Akut Ekstrak Akar Alang-Alang (Imperata cylindrica).
Abstrak: Cagon grass (Imperata cylindrica), a wild plant, is one of the herbs plant that has been used traditionally to threat fever, cough, hypertensi, and acute hepatitis. This research was designed to study the safety level by acute toxicity test and analyze hepatoprotector activity of ethanol extract from root of Imperata cylindrica in Wistar rats induced by paracetamol. Hepatoprotector activity was measured by using biochemical parameters such as alanine amino transferase (ALT) and aspartate amino transferase (AST) and observation of histopathology. Root of Imperata cylindrica that extracted by using ethanol 70% gave rendement about 12.48%. Phytochemical test shows that ethanol extract from root of Imperata cylindrica contains alkaloid and triterpenoid. Acute toxicity test shows that ethanol extract from root of Imperata cylindrica is practically nontoxic because its LD50 is higher than 15000 mg/Kg BB. Transaminase anzyme serum analysis shows that the induction of ethanol extract of Imperata cylindrica dose 750 mg/Kg BB gives a significant effect compared with dose 250 and 500 mg/Kg BB, even with curliv as positive control. This result based on activity of ALT and AST, 68.6 and 221.2 U/L (normal group), 222.2 and 509.6 U/L (dose 750 mg/Kg BW), 491.2 and 576.4 U/L (positive control), 517.4 and 527.8 U/L (dose 500 mg/Kg BW), 555.6 and 660.0 U/L (negative control), and 558.4 and 595 U/L (dose 259 mg/Kg BW). Liver histopathology shows there is no fibrosis and other damages in liver of group VI. This result indicates that ethanol extract from root of Imperata cylindrica has a potention as hepatoprotector.
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Judul: Aktivitas hepatoprotektor ekstrak metanol daun kari (Murraya koenigii .L.) pada tikus putih Sprague dawley, Activity of Curry Leaf (Muraya koenigii. L.) Methanol Extract as Hepatoprotector in Sprague dawley Rats
Abstrak: Curry leaf is being thought as hepatoprotector againts liver damage caused by hepatotoxic agent such as paracetamol. This study was assesing the activity of curry leaf extract in reducing the activity of ALT (alanine aminotransferase) and AST (aspartate aminotransferase) in rats were given high dose paracetamol. Total of 25 rats were used in this research which were divided into 5 experimental groups as follows: normal control group (N), negative control group (KN) (paracetamol dose 500 mg/Kg BW were given 21 days), positive control group (KP) (curliv dose 42.86 mg/Kg BW were given 21 days), dose 200 mg/Kg BW extract group (ED200), and dose 300 mg/Kg BW extract group (ED300). Extracts were given 7 days before paracetamol treatment and continous until end of experiment. Pytochemistry test results showed that curry leaf methanol extract contain alcaloids, tannins, saponins, and steroids. Extract group had not significantly reduced ALT and AST activity (p>0.05) compared to N group. Decreasing ALT and AST activity in ED200 group is 16.21% and 33.82%. Decreasing ALT and AST activity in ED300 group is 33.82% dan 62.60%. Methanol extract curry leaf had hepatoprotector activity although not significantly differences.
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Judul: Pengembangan model markov tersembunyi pada identifikasi pembicara
Abstrak: Model Markov Tersembunyi merupakan suatu model yang tersusun dari dua buah proses stokastik, yaitu rantai Markov untuk menampung kemajuan temporal dan proses yang teramati untuk menampung variasi akustik. Model ini dapat digunakan sebagai metode pencocokan pola pada sistem identifikasi pembicaraan. Setiap model mewakili referensi pola dari seorang pembicara di dalam sistem identifikasi pembicara.
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