Judul: IPB (Bogor Agricultural University)
Abstrak: Tujuan penelitian ini adalah mengevaluasi aktivitas antiproliferasi sel lestari tumor dan fagositosis secara in-vitro dari fraksi bioaktif yang diisolasi dari rimpang temu putih (Curcuma zedoaria ). Serbuk rimpang temu putih diekstraksi dengan pelarut organik (n-heksana, metanol dan etil asetat). Lima fraksi (A-E) dari ekstrak etil asetat diperoleh dengan teknik kromatografi menggunakan SiO 2 gel 60 dan fase gerak nheksana/ etil asetat (0-100%). Fraksi bioaktif (B dan C) dimurnikan dengan kromatografi cair kinerja tinggi (KCKT) dan diperoleh 1 fraksi (B-1) dari fraksi B dan 3 fraksi (C-1,C-2 dan C-3) dari fraksi C. Karakterisasi kimia dilakukan pada fraksi B-1 dan C-1 meliputi spektroskopi UV-Vis, infra merah dan massa. Pengujian bioaktivitas yang dilakukan adalah uji toksisitas terhadap larva udang (Artemia salina), uji antiproliferasi terhadap sel lestari tumor (sel HeLa, K-562, WEHI 164), aktivitas fagositosis terhadap Staphyllococcus epidermidis, analisis jumlah kromosom sel tumor dan perubahan morfologi dari sel lestari tumor.
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Judul: Aktivitas Antiproliferasi Berbagai Tanaman pada Sel MCF-7 dan Kajian Korelasi Aktivitas dengan Profil Spektrum Inframerahnya
Abstrak: Herbal plants have been used as anticancer for low-cost treatment with minimum side effects for human. The objective of this study is to analyze toxicity leaves of mulberry (Morus alba), salam (Syzygium polyanthum), rumput mutiara (Oldenlandia corymbosa), avocado (Persea americana), mengkudu (Morinda citrifolia), pacing (Costus speciosus), jarong (Stachytarpheta indica), dadap, and huni (Antidesma bunius), and to determine correlation between antiproliferation activities in MCF-7 cells produced by best extracts and their infrared profiles. Toxicity assay using brine shrimp lethality test showed that mulberry methanol extract, rumput mutiara ethanol extract, and dadap ethanol extract showed low LC50 values of 134 μg/mL, 22 μg/mL, and 152 μg/mL, respectively. Proliferation assay in MCF-7 cells did not show positive correlation between concentration of extracts and inhibition percent, therefore the IC50 values could not be determined. Correlation analysis using PLS technique showed that correlation between infrared spectra and percent inhibition of extracts revealed low R2 valueswith high RMSEC and RMSEP values.
Keyword: Bogor Agricultural University (IPB), MCF-7 cells, infrared spectra, correlation analysis, antiproliferation

Judul: Construction of Strongly Optimal Binary Linear Code with Minimum Distance 9 and 11
Abstrak: A binary linear code of length n over q F is a subspace of n q F . A code has three parameters that attached to it, namely length, dimension, and minimum distance. A code with length n, dimension k and minimum distance d is often called [n, k, d ]-code. Usually, when two parameters are given, then we want to find a code that has the best value for the last parameter. Based on Gilbert- Varshamov bound, if a [n, k, d ]-code exists and can not be expanded, we call it a strongly optimal code. In this paper, we construct strongly optimal code with minimum distance 9 and 11. In constructing the code, we created a theorem and algorithm based on Gilbert-Varshamov bound before we implement the algorithm to MAPLE programming language. Because of computational limitations, the program can only construct up to k = 10 for d = 9 and k = 12 for d = 11.
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