Judul: Profil Fitokimia dan Toksisitas Ekstrak Rimpang Temu Ireng (Curcuma aeruginosa R.) pada Larva Udang
Abstrak: Curcuma aeruginosa berpotensi sebagai tanaman herbal karena mengandung metabolit sekunder. Penelitian ini bertujuan menentukan profil fitokimia dan toksisitas larva udang pada ekstrak rimpang induk, anak, dan cucu temu ireng. Ekstrak ketiga rimpang temu ireng didapatkan dengan teknik maserasi menggunakan pelarut etanol 96%, etanol 70%, dan akuades. Selanjutnya, ekstrak digunakan dalam analisis komponen fitokimia dan aktivitas toksisitas terhadap larva udang Artemia salina L. Kadar air ketiga simplisia berada dibawah 10%. Rendemen tertinggi dimiliki oleh ekstrak akuades, sedangkan ekstrak etanol 96% memiliki rendemen terendah. Semua ekstrak mengandung tanin, saponin (kecuali ekstrak induk dalam etanol 96%), dan triterpenoid. Komponen fitokimia pada tanaman herbal dapat bersifat toksik pada konsentrasi tertentu. Uji BSLT (Brine Shrimp Lethality Test) digunakan untuk mengetahui konsentrasi ekstrak yang mampu membunuh 50% populasi (LC50). Uji toksisitas untuk farmakologi awal menunjukkan ekstrak induk dalam etanol 96% berpotensi sebagai obat herbal karena bersifat sangat toksik dengan LC50 sebesar 90.40 µgmL-1.
Keyword: Curcuma aeruginosa, Phytochemical, Toxicity, Type of Rhizome, Biokimia, Jenis rimpang, Pebuatan ekstrak kasar rimpang, Shrimp

Judul: Uji Toksisitas Ekstrak Etanol Rimpang Temu Putih terhadap Larva Udang dan Embrio Ikan Zebra
Abstrak: Curcuma zedoaria, known as temu putih, is commonly used as traditional medicine in Indonesia. The toxicity of this herb needs to be studied to improve its application. This research aims to evaluate the toxicity of the crude ethanol extract of temu putih rhizome against brine shrimp (Artemia salina) larvae and zebrafish (Danio rerio) embryos and to analyze the suspected active compounds contained in the extract. The crude ethanol extract showed 50% lethal concentration value (LC50) at 588 ppm against brine shrimp larvae and 215 ppm against zebrafish embryos. In zebrafish embryos, exposure of the crude ethanol extract has caused major malformation in development of head, namely brain and eyes organs. Based on the gas chromatography-mass spectrometry analysis, the suspected active compound that play a role in the toxicity are epicurzerenone, curzerene, and curzerenone, which 2,4,6-trimethylacetophenone as the predominant compound.
Keyword: Bogor Agricultural University (IPB), LC50, Danio rerio, Curcuma zedoaria, Artemia salina

Judul: Construction of Strongly Optimal Binary Linear Code with Minimum Distance 9 and 11
Abstrak: A binary linear code of length n over q F is a subspace of n q F . A code has three parameters that attached to it, namely length, dimension, and minimum distance. A code with length n, dimension k and minimum distance d is often called [n, k, d ]-code. Usually, when two parameters are given, then we want to find a code that has the best value for the last parameter. Based on Gilbert- Varshamov bound, if a [n, k, d ]-code exists and can not be expanded, we call it a strongly optimal code. In this paper, we construct strongly optimal code with minimum distance 9 and 11. In constructing the code, we created a theorem and algorithm based on Gilbert-Varshamov bound before we implement the algorithm to MAPLE programming language. Because of computational limitations, the program can only construct up to k = 10 for d = 9 and k = 12 for d = 11.
Keyword: