Judul: Penyimpangan Iklim dan Resiko Kebakaran Hutan dan Lahan di Sumatera
Abstrak: Sumatera merupakan salah satu wilayah di Indonesai yang selalu mengalami kebakaran hutang dan lahan setiap tahun. namun pada saat terjadi penyimpangan iklim yang menyebabkan kekeringan, jumlah kejadian kebakaran hutan dan lahan meningkat secara nyata. Penyimpangan iklim akibat Indian Ocean Dipole Mode (ENSO) telah diteliti, tetapi penyimpangan iklim akibat Indian Ocean Dipole Mode (DME) belum diteliti. Selain iklim, resiko kebakaran hutan dan lahan juga dipengaruhi oleh kondisi vegetasi dan kondisi lahan. Permasalahan kebakaran hutan dan lahan tidak hanya menyangkut aspek biofisik, tetapi juga kebijakan. Untuk membuat kebijakan yang tepat, maka faktor-faktor penyebabnya perlu dianalisis dan akar masalah kebakaran hutan dan lahan perlu dirumuskan dengan tepat.
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Judul: Hubungan Curah Hujan dengan Kejadian Kebakaran Hutan dan Lahan di Provinsi Sumatera Selatan
Abstrak: Forest existence in Indonesia is vulnerable due to a disturbance, particularly forest fire. One of the causes of forest and land fire is the weather condition which is so fierce in the drought season. South Sumatera is an area with high vulnerability of forest fire, it is included into three provinces with the highest forest fire occurrence in Indonesia. This research aim to analize the influence of precipitation toward the forest and land fire occurrences at South Sumatera province. The result shows that the drought season in South Sumatera occur from July until September, with the peak season at August. The number of hotspot increase between May until October with peak of forest fire occurrence at September, right after the peak of drought season at August. It is clearly showed that daily and 10-daily mean of daily precipitation could be used to explain forest fire occurences. The result of this research emphasize that forest fire prevention in South Sumatera strongly suggested to be started at May when the number of precipitation decrease drastically and the number of hotspot increase
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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