Judul: Formulasi Jamu Baru Antikolesterol Melalui Studi Bioinformatika Pangkalan Data Jamu dengan Ikan Zebra sebagai Hewan Model
Abstrak: Jamu formulation is based on pharmacological activity of the constituents. New jamu formula consisting of three supporting plants (analgesic, antibacterial, and antiinflammatory) and the main plant becoming efficacy target (anticholesterol). This new jamu was formulated using PLS (partial least square) with R-Gui software version 2.15.2 generated formula consisting of a mixture of Merremia mammosa tubers, leaves of Guazuma ulmifolia, Orthosiphon stamineus, and Murraya paniculata as the main plant. The formula was tested on zebrafish. The tested jamu formula were jamu formula 1 consisting of a mixture of the four plants with main plant as the most component and formula 2 with the main plant as single component. The total cholesterol average of zebrafish under normal condition was 220 mg/dL (p>0.05), while on the hypercholesterolemia condition was 272 mg/dL (p>0.05). After giving the extract for 7 days, formula 2 lowered total cholesterol greater than that of the formula 1; however, those values were not significantly different at the alpha value (p>0.05).
Keyword: zebrafish, total cholesterol, jamu formulations, anticholesterol

Judul: Pendekatan Bioinformatika Formulasi Jamu Baru Berkhasiat Antidiabetes dengan Ikan Zebra (Danio rerio) sebagai Hewan Model
Abstrak: Jamu composition was formulated without any provision like Traditional Chinese Medicine. Recent studies showed regularity pattern through statistical database. Jamu formulations in this study were made using Design Expert and its efficacy predicted using models partial least square discriminant analysis (PLSDA), coefficient PLSDA multiways, and Support Vector Machine. The prediction indicated that 4 plants used were sembung, pare, ginger, and bratawali. The efficacy was verified using zebrafish (D. rerio) as an animal test. Hyperglycemia in the fish was induced by soaking them in alloxan 0.1% for 10 min, glucose 1% for 10 min, and distilled water for 60 min in sequence. One-way t test showed that the increasing blood sugar levels was not significant (p>0.05). These results confirm that the induction process have not been successful to increase the average blood sugar levels. Application of jamu into the fish was done for 3 days after the induction. Statistical observation for all compositions of jamu showed that group 1 has the greatest decline difference.
Keyword: zebrafish, jamu, bioinformatic of jamu, antidiabetic

Judul: Pembangunan Perumahan Pada Wilayah Desakota Kaitannya Dengan Sistem Sosial Masyaraka t Asli
Abstrak: Faktor utama yang banyak mempengaruhi meningkatnya jumlah perumahan dan pemukiman pacta wilayah desakota adalah adanya tekanan populasi sebagai akibat dari migrasi besar-besaran menuju daerah desakota. Dengan kata lain, lokasi perumahan atau pemukiman menjadi tak memiliki banyak pilihan lagi, kota telah sesak dan sasaran selanjutnya para pengais materi di daerab kota adalab wilayah desakota. Masyarakat asli yang sejak lama tinggal di wilayah desakota merupakan bagian dari masyarakat desakota yang perlu diperhatikan. Baik disadari maupun tidak disadari, perubaban pada masyarakat asli desakota akan terjadi karena masyarakat selalu dalam keadaan dinamis. Selain itu perubahanjuga akan terjadi dikarenakan masyarakat adalah sistem yang terdiri dari bagian-bagian yang berhubungan serta berintegrasi secara fungsional, sehingga perubaban pada satu fungsi dari masyarakat akan mempengaruhi fungsi lainnya.
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