Judul: Pengaruh Pemberian Kitosan terhadap Kadar Trigliserida Darah & Berat Badan Tikus Sprague-dawley yang Diberi Pakan Asam Lemak Trans
Abstrak: This study was aimed to analyze chitosan intake on plasma triglyceride levels and body weight in rats Sprague-dawley fed by trans fatty acid. This study was experimental study with Post Test Only Control Group Design. The subjects were male Sprague-dawley rats, 2 months old. The subjects were divided in to 1 control (K) and 3 treatment groups which received chitosan as much as 0.035 g (P1), 0.045 g (P2), and 0.055 g (P3). Fed with high-fat diet was given by melted margarine as source of trans fatty acids as much as 1.7 g per day for 4 weeks. Measurement of triglyceride levels was done at second week dan fourth week after intervention and the body weight was weighed once per 3 days. The study revealed that feeding of margarine in a dose of 1.7 g per day increased body weight most high in K0 amount 32.1% or 63.8 g during 2 weeks and 54% or 107.2 g during 4 weeks intervention. The average of triglyceride levels K (254.3±49.0 mg/dL) and P1 (241.7±58.5 mg/dL) at second week. The average of triglyceride levels K (175.3±67.7 mg/dL) and P1 (181.3±40.1 mg/dL) at fourth week. Both of second and fourth week the average of triglyceride levels K and P1 were cathegorize in hypertriglyceridemia. Chitosan intake on fed inhibited increasing body weight on P2 (0.045 g) amount 53.4 g or 23.3% during 2 weeks and 63.6 g or 27.8% during 4 weeks. Chitosan intake 0.045 g on P2 decreased triglyceride levels (128.3±14.3 mg/dL) significantly than K (p=0.009) at second week. Thus, there were an opotimum dose of chitosan influence body weight and trigliceride levels.
Keyword: trans fatty acids and triglyceride, chitosan, body weight, Bogor Agricultural University (IPB)

Judul: Efek Kitosan Dan Nanokitosan Dari Karapas Udang Dalam Mereduksi Kadar Trigliserida Tikus Sprague-Dawley
Abstrak: Kitosan merupakan suatu produk hasil deasetilasi kitin yang dapat digunakan untuk mereduksi kadar trigliserida. Kitosan nanopartikel memiliki ukuran yang lebih kecil, sehingga lebih efektif dalam mereduksi kadar trigliserida. Tujuan dari penelitian ini adalah untuk menentukan karakteristik kitosan dan mempelajari pengaruh kitosan, nanokitosan dan dosisnya dalam mereduksi kadar trigliserida tikus yang diberi diet pakan tinggi lemak. Hewan percobaan yang digunakan adalah tikus Sprague-dawley. Hewan percobaan dikelompokkan dalam enam perlakuan, yaitu kontrol negatif, kontrol positif, perlakuan yang diberikan kitosan dan nanokitosan dengan dosis berturut-turut 225 mg/kg bb dan dosis 450 mg/kg bb. Pengukuran kadar trigliserida dilakukan dengan menggunakan metode kolorimetri enzimatik-gliserol-3-fosfat oksidase. Pengukuran kadar trigliserida dilakukan setelah masa adaptasi, setelah pemberian pakan tinggi lemak dan setelah masa perlakuan. Penimbangan berat badan tikus dilakukan setiap satu minggu. Hasil penelitian menunjukkan bahwa kadar trigliserida dan berat badan tikus mengalami peningkatan setelah pemberian pakan tinggi lemak selama dua minggu. Pemberian kitosan dan nanokitosan selama dua minggu dapat menurunkan kadar trigliserida tikus. Perlakuan pemberian nanokitosan dengan dosis 450 mg/kg bb (NK2) mampu menurunkan kadar trigliserida tikus dengan persen penurunan paling tinggi daripada perlakuan K1, K2 dan NK1, yaitu sebesar 23,42 % dari 111,00 ± 13,29 menjadi 85,00 ± 32,93 mg/dL.
Keyword: Kitosan, dosis, nanokitosan, Sprague-dawley, trigliserida

Judul: Query Expansion based on Bilingual Dictionary Using Conditional Probability
Abstrak: Query expansion is a technique that can be used to bridge vocabulary gaps between queries and documents in the collection. With query expansion, user will be helped to formulate queries well so that user will optimize the search result. In this study, the expansion term was resulted from the translation of bilingual dictionary. Subsequently, several terms of expansion were elected based on the closeness of its relationship with the original query. This research showed that conditional probability can be used to select expansion term in bilingual translation method query expansion. The result of 1000 documents was more than 97% relevan document can be retrieved by this system. The more expansion term used, the larger number relevan document was retrieved.
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