Judul: Daya Hambat Siklooksigenase-2 oleh Campuran Ekstrak Suruhan (Peperomia pellucida) dan Jahe Merah (Zingiber officinale) dalam Inflamasi
Abstrak: Peperomia pellucida and Zingiber officinale were known to have anti-inflammatory activity, yet there was no further research to verify their inhibition in inflammatory process. The aim of this research is to test the potency of mixture extract of suruhan (Peperomia pellucida) and red ginger (Zingiber officinale) as anti-inflammation through in vitro inhibition of cyclooxygenase-2 enzyme. Anti-inflammatory effect was analyzed with ELISA (Enzyme Linked Immunosorbent Assay) and spectrophotometry method at wavelenghth 412 nm. Maximum inhibition of Peperomia pellucida extract against cyclooxygenase-2 was 48% at 100 μg/mL, Zingiber officinale extract inhibition was 44% at 300 μg/mL, and for mixture extract inhibition was 15% at 175 μg/mL. Mixture extract of Peperomia pellucida and Zingiber officinale showed lower inhibitory potency to cyclooxygenase-2 compared to their single extracts. Cytotoxicity test with Brine Shrimp Lethality Test method showed that Peperomia pellucida extract, Zingiber officinale extract, and mixture extract of both plants have a cytotoxity effect with each LC50 values are 339, 591, and 728 μg/mL. Phytochemical test showed that each extract contains flavonoid, phenolic, alkaloid, and tannin. Saponin and steroid were contained only in Peperomia pellucida extract and terpenoid was contained only in Zingiber officinale extract. Rendement extract of Peperomia pellucida is 24% and Zingiber officinale is 21%.
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Judul: Khasiat Antiinflamasi Ekstrak Herba Suruhan (Peperomia pellucida [L]) dan Campurannya dengan Jahe Merah (Zingiber officinale Rosc.) pada Tikus
Abstrak: Suruhan herb has been reported for its anti-inflammatory activity, but its usage are still limited. Besides suruhan herb, the other plant which can be used as anti-inflammatory drugs is red ginger. The objective of this research was to test the effectivity of the formula mixture of suruhan herb and red ginger extracts as anti-inflamation in vivo. A total of 24 male white Wistar strain rats were divided into six groups: the control group (CMC 0.5%), the sodium diclofenac (1.25 mg/kg BB), the suruhan herb (100 mg/kg BW), the suruhan herb (117.5 mg/kg BW), the formula 1 extract, and the formula 2 extract. The volume of the rats carrageenan-induced foot paw was measured using plethysmometer for six hours. The results showed that carragenan-induced increased the foot paw of rats. Eventhough data were not statistically significant, suruhan herb-ginger extract tended to reduce inflammation in vivo. The effect was the same as the commercialized anti-inflammatory drugs natrium diclofenac and was better than the single extract. The percentage of inflammatory inhibition of formula 1 was 33.69% and formula 2 was 28.31%. Moreover, mixture of suruhan herb-ginger extract reduced leukocytes level more than natrium diclofenac.
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Judul: Construction of Strongly Optimal Binary Linear Code with Minimum Distance 9 and 11
Abstrak: A binary linear code of length n over q F is a subspace of n q F . A code has three parameters that attached to it, namely length, dimension, and minimum distance. A code with length n, dimension k and minimum distance d is often called [n, k, d ]-code. Usually, when two parameters are given, then we want to find a code that has the best value for the last parameter. Based on Gilbert- Varshamov bound, if a [n, k, d ]-code exists and can not be expanded, we call it a strongly optimal code. In this paper, we construct strongly optimal code with minimum distance 9 and 11. In constructing the code, we created a theorem and algorithm based on Gilbert-Varshamov bound before we implement the algorithm to MAPLE programming language. Because of computational limitations, the program can only construct up to k = 10 for d = 9 and k = 12 for d = 11.
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