Judul: Anticancer activity of green leaf gel cincau ( Premna oblongifolia Merr) powder via apoptosis and antiproliferation pathway in C3H mice transplanted with breastcancer cell
Abstrak: Green leaf gel Cincau (Premna oblongifolia Merr) powder is a rich sources of various phytochemicals including alkaloid, saponin, flavonoid, chlorophyl dan carotenoid. In this research the gel extracted from Cincau leaf and made into powder. Green leaf gel Cincau powder activity was conducted on C3H mice were transplanted with breastcancer of Mouse Mamary Tumour Viruses (MMTV). The objectives of the research are to investigate the effect of green leaf gel Cincau on apoptosis and proliferation inhibitions in C3H mice and explored its mechanism.
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Judul: Pengaruh Bubuk Daun Cincau Hijau (Premna oblongifolia Merr.) terhadap Gambaran Histopatologi Serta Ekspresi Protein Proapotosis dan Antiapoptosis pada Adenocarsinoma Mammae Mencit C3H.
Abstrak: Cancer is very closely associated with food consumption. Natural foods such as fruits and vegetables have been proven to have many benefit effects to body health. Bioactive compound from plants have antitumor activity. Green leaf of P.oblongifolia Merr. had been proven to have activity on tumor growth resistance in C3H mice. The purposes of this study were to know the influence of green P.oblongifolia Merr. leaf powder as anti cancer activity on C3H mice by analyzing tumor tissue histopatology, expression of JNK 1/2 and caspase-7 as proapoptosis protein and expression of ERK 1/2 and COX-2 as antiapoptosis protein. C3H mice (n=25) were devided into 5 groups. The first is a standard negatif group (A) and the second group was a positif control group (B), both were treated with standard diet containing 0% green leaf powder. Group C, D and E were given standart diet containing green leaf powder 0,88%, 1,76%, and 2,64%. The diets were given for 30 days. At 31st day the mice in groups B,C, D and E were transplanted with MMTV cancer cells. The diet was continued to 52nd day and at 53rd day all mice were terminated to obtain the cancer tissue. Parameters observed covering consumption of diet, body weight, tumor growth latent period, volume and weight of cancer tissue. Histopatology analysis was comprised of hematoxilin eosin (HE) and imunohistochemical (IHC) staining. The IHC were done using four antibodies which are anti-phospho-JNK 1/2, anti-COX-2, anticaspase-7, and anti-phospho-ERK 1/2. Delta of mice body weight before and after transplantation was not significantly different (p>0,05). Cancer latency period was not significanly different (p>0,05). Cancer volume increased significantly in positif control group (p<0,05). Cancer tissue weight of groups D and E were significantly lower compared to the other groups (p<0,05). The results showed that the mice that given green leaf powder (P. oblongifolia Merr.) exhibited less development of cancer growth mainly in groups D and E, which was supported by HE score. The HE staining showed that the cancer tissues of groups D and E have the least average differentiation and mitotic scores. In this study IHC staining for proapoptotic markers as JNK 1/2 and caspase-7 and for antiapoptotic markers as ERK 1/2 and COX-2 have not yet indicated positive expression.
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Judul: Pembangunan Perumahan Pada Wilayah Desakota Kaitannya Dengan Sistem Sosial Masyaraka t Asli
Abstrak: Faktor utama yang banyak mempengaruhi meningkatnya jumlah perumahan dan pemukiman pacta wilayah desakota adalah adanya tekanan populasi sebagai akibat dari migrasi besar-besaran menuju daerah desakota. Dengan kata lain, lokasi perumahan atau pemukiman menjadi tak memiliki banyak pilihan lagi, kota telah sesak dan sasaran selanjutnya para pengais materi di daerab kota adalab wilayah desakota. Masyarakat asli yang sejak lama tinggal di wilayah desakota merupakan bagian dari masyarakat desakota yang perlu diperhatikan. Baik disadari maupun tidak disadari, perubaban pada masyarakat asli desakota akan terjadi karena masyarakat selalu dalam keadaan dinamis. Selain itu perubahanjuga akan terjadi dikarenakan masyarakat adalah sistem yang terdiri dari bagian-bagian yang berhubungan serta berintegrasi secara fungsional, sehingga perubaban pada satu fungsi dari masyarakat akan mempengaruhi fungsi lainnya.
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