Judul: Perkembangan Embrio Ikan Zebra (Danio Rerio) Setelah Paparan Ekstrak Etanol Temu Lawak (Curcuma Xanthorrhiza) Dan Temu Putih (Curcuma Zedoaria).
Abstrak: Temu lawak dan temu putih merupakan obat tradisional yang telah digunakan secara turun-temurun. Kedua tanaman ini telah dilaporkan bersifat toksik pada embrio ikan zebra. Penelitian ini bertujuan untuk mempelajari perkembangan embrio ikan zebra setelah paparan ekstrak temu lawak, temu putih, dan campurannya. Nilai LC50 ekstrak etanol temu lawak, temu putih, dan campurannya berturut-turut adalah 16.9, 112.1, dan 82.9 ppm. Ekstrak temu lawak menyebabkan penghambatan proses menetas pada embrio ikan zebra, sebaliknya ekstrak temu putih tidak menunjukkan efek penghambatan tersebut. Malformasi mayor yang terjadi pada embrio ikan zebra akibat paparan ekstrak temu lawak adalah edema perikardium, koagulasi darah, notokorda, dan edema kantong kuning telur; akibat paparan temu putih adalah edema perikardium dan koagulasi darah; serta akibat paparan campuran keduanya adalah edema perikardium, koagulasi darah, dan sirkulasi darah. Ekstrak temu putih memiliki sifat antagonis terhadap ekstrak temu lawak, yaitu mampu menghilangkan efek penghambatan proses menetas serta menurunkan kelainan pada notokorda dan kantong kuning telur.
Keyword: abnormalitas, embrio ikan zebra, LC50, temu lawak, temu putih

Judul: Uji Toksisitas Ekstrak Etanol Rimpang Temu Putih terhadap Larva Udang dan Embrio Ikan Zebra
Abstrak: Curcuma zedoaria, known as temu putih, is commonly used as traditional medicine in Indonesia. The toxicity of this herb needs to be studied to improve its application. This research aims to evaluate the toxicity of the crude ethanol extract of temu putih rhizome against brine shrimp (Artemia salina) larvae and zebrafish (Danio rerio) embryos and to analyze the suspected active compounds contained in the extract. The crude ethanol extract showed 50% lethal concentration value (LC50) at 588 ppm against brine shrimp larvae and 215 ppm against zebrafish embryos. In zebrafish embryos, exposure of the crude ethanol extract has caused major malformation in development of head, namely brain and eyes organs. Based on the gas chromatography-mass spectrometry analysis, the suspected active compound that play a role in the toxicity are epicurzerenone, curzerene, and curzerenone, which 2,4,6-trimethylacetophenone as the predominant compound.
Keyword: Bogor Agricultural University (IPB), LC50, Danio rerio, Curcuma zedoaria, Artemia salina

Judul: Penyelesaian Stacker Crane Problem dengan Algoritme Largearcs dan Smallarcs
Abstrak: In graph theory, the Rural Postman Problem (RPP) aims to determine the shortest route with minimum cost, in which only certain edges or arcs are necessarily traversed. One type of RPP is Stacker Crane Problem (SCP) which deals with a mixed graph but only arcs are necessarily traversed. SCP can be solved by using two heuristic algorithms, i.e. Largearcs and Smallarcs algorithms, which include other algorithms in their steps, such as: Dijkstra algorithm to determine shortest route, Hungaria method to determine minimum bipartite matching, Prim algorithm to determine minimum spanning tree, and van Aardenne-Ehrenfest & de-Bruijn algorithm and Fleury algorithm to determine Euler circuits. The shortest Euler circuit resulted from two heuristic algorithms can be used to find a solution of SCP. The application of SCP is illustrated in establishing the minimum distance route of catering delivery.
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