Judul: Potensi Antiproliferasi Ekstrak Lamun (Enhalus acoroides) Pulau Bintan pada Sel HeLa secara In Vitro
Abstrak: ditemukan pada tanaman darat. Senyawa bioaktif dapat digunakan sebagai salah satu alternatif untuk mengobati penyakit seperti kanker. Penelitian ini bertujuan untuk menentukan aktivitas antiproliferasi E. acoroides terhadap sel HeLa secara in vitro. Metode penelitian ini terdiri atas maserasi daun E. acoroides dengan pelarut etil asetat, metanol, dan etanol, pengukuran total fenol dengan Follin-Ciocalteu, skining komponen fitokimia, brine shrimp lethal test, dan uji viabilitas sel dengan MTT. Hasil uji BSLT dan MTT menunjukkan ekstrak memiliki kemampuan sitotoksik. Nilai LC50 terendah sebesar 406.03 ppm terdapat pada ekstrak etanol 70% E. acoroides. Pertumbuhan sel HeLa juga dapat dihambat oleh ekstrak etanol 70% E. acoroides dengan nilai IC50 sebesar 212.354 ppm. Hal ini menunjukkan bahwa E. acoroides memiliki aktivitas sitotoksik dan antiproliferasi terhadap sel HeLa.
Keyword: antiproliferasi, Enhalus acoroides, lamun, sel HeLa, MTT

Judul: Eksplorasi Senyawa Bioaktif Dan Uji Antibakteri Dari Lamun Enhalus Acoroides
Abstrak: Enhalus acoroides merupakan salah satu jenis lamun yang memiliki potensi sebagai sumber bahan bioaktif. Tujuan penelitian ini adalah mengeksplorasi senyawa bioaktif dan menganalisis hasil uji antibakteri. Ekstraksi dengan metode maserasi dan dievaporasi. Ekstrak kasar yang diperoleh kemudian diuji fitokimia, Brine Shrimp Lethality Test (BSLT), dan uji aktivitas antibakteri. Rendemen ekstrak dengan pelarut metanol lebih besar dibandingkan dengan pelarut n-heksana, yaitu 9.98% dan 5.72%. Komponen bioaktif pada ekstrak kasar metanol meliputi, flavonoid, tanin, saponin, dan steroid. Komponen bioaktif pada ekstrak kasar n-heksana adalah steroid. Nilai LC50 pada ekstrak n-heksana bernilai 1049.23 ppm (tidak toksik) dan 62.53 ppm (toksik) ekstrak metanol. Ekstrak metanol lebih efektif untuk menghambat pertumbuhan bakteri Staphylococcus aureus dan Escherichia coli.
Keyword: antibakteri, bioaktif, Enhalus acoroides, Escherichia coli, Staphylococcus aureus

Judul: Thermal Characteristics and Dynamics of Tropical Cyclone over Western North Pacific Ocean: A Case Study of Typhoon Songda (Chedeng) 2011
Abstrak: The frequent occasion of Tropical Cyclone (TC) over Western North Pacific (WNP) Ocean lies from 10˚N to 26˚N and 121˚E to 170˚E. Sources of TC development come from warm ocean temperature where latent heat is released during condensation processes and subsequently concentrated in the boundary layer. Relative humidity at 850-700 hPa is responsible to produce the most intense storm. Meanwhile, weak vertical wind shear between 850-200 hPa is one of the dynamical factors that lead to the development of TC. Pressure level of 850-200 hPa is chosen to minimize the thermodynamic effect in the lower troposphere. Typhoon Songda (Chedeng in the Philippines) or TSC lasted from May 18th to 30th, 2011 and strengthened into powerful Super Typhoon stage between May 24th and 27th. Long curving track and the exhibition of all sequences of TC life cycle, TSC is then considered as an ideal case of TC. The objective of the study with case of TSC is to investigate the role of thermal characteristics and dynamics on TC intensity. The research is carried out by using Advanced Research of Weather Research and Forecasting model (WRF ARW model) version 3.3. Two domains are employed in the model. The first domain situate from 02˚N to 40˚N and 118˚E to 149˚E and cover spatial resolution () of 33.1 km. The second domain situate from 09˚N to 27˚N and 119˚E to 132˚E with of 11 km. Timestep of the model () is 120 seconds. The model is supported by the following physical parameterization, i.e., Yonsei University Scheme (YSU) in the boundary layer, Kain-Fritsch scheme (KF) in the cumulus, and WRF Single-Moment 3-class scheme in the microphysics. Initial meteorological condition prior to the formation of the cyclone is generated using WRF ARW standard-release model. Sensitivity of the model output is obtained from a selected single-parameter change scenarios, namely, 10 % to 20 % decrease and increase of wind shear initial data at 850-200 hPa, and by 10 % to 20 % decrease of relative humidity initial data at 850-700 hPa. The result showed that the negative correlations between wind shear and intensity are found in wind shear scenarios. Wind shears of 10 ms-1 which lead to strengthening of the wind intensity in the early period of Typhoon development are found in wind shear scenarios. The effect of wind shear changes on wind intensity is statistically significant in the 20 % wind shear scenarios. During mature stage, weak wind intensity occurred when wind shear increase as given in the WRF standard-release and the 20 % decreasing scenario. Different situation is found in the 20 % increasing scenario where wind shear tend to weak and lead to strong wind intensity at this stage. Meanwhile, the reduction of moisture supply at 850-700 hPa resulting from 20 % decreasing relative humidity play a major role in the weakening of wind intensity and reduces mechanical energy of the cycle process as much as 300 J kg-1.
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