Judul: Aktivitas Sitotoksik dan Apoptosis Sel Khamir Ekstrak Kloroform Kapang Endofit Evodia suaveolens
Abstrak: Cancer can occur if the cell cannot be sustained in the amount fixed. Cells that have failed apoptosis, they will division continously. Apoptosis is the process of programmed cell death. Apoptosis in yeast cell can be used as model because yeast cell cycle similar to human cell. Evodia suaveolens produce evodiamine, it trigger apoptosis. Endophytic mold produce bioactive compounds that similar to its host plant. Eight isolates endophytic mold have been isolated from steam of Evodia suaveaolens. Endophytic mold then was fermented and secondary metabolites was extracted with chloroform. Then the extracts was tested using cytotoxic activity with BSLT (Brine Shrimp Lethality Test) method. Values of LC50 from each endophytic mold of Evodia suaveolens are 315 ppm (mold 1), 270 ppm (mold 3), 400 ppm (mold 5), 19.7 ppm (mold 7), and 403 ppm (mold 8). Mold 2,4, and 6 is not toxic in 500, 100, 50, and 10 concentration. Each concentration of LC50 used for apoptosis induction in yeast cell. Percentation of yeast cell that have petite from mold 1, mold 3, mold 5, mold 7, and mold 8 are 69%, 75%, 86%, 90%, and 90.4% respectively. This percentation showed that isolate 1, 3, 5, 7, 8 from endophytic mold Evodia suaveolens can induction apoptosis in yeast cell.
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Judul: Kemampuan Ekstrak Dedaunan Berpotensi Antioksidan Untuk Memodulasi Apoptosis Pada Sel Khamir.
Abstrak: One of the causes of cardiovascular disease is atherosclerosis. Some of medicinal herbs extracts which are reported to have anti atherosclerotic property are Guava leaves extract, Jati Belanda leaves extract, and Salam leaves extract. Apoptosis occures in atherosclerosis lesions intima. So this research is to determine that the capability of some herbal extracts to modulate apoptosis in yeast cells. For that purpose, yeast cells are used as model, as they will become small colonies (petite colonies) when apoptosis is induced. Yeast cells were incubated into 50 ppm, 100 ppm, 200 ppm, 1000 ppm, and 2000 ppm of each extracts, previously had been enriched in sterile YEPD and Petite Broth. On day 3 and 4, yeast cells were spread into YEPD and Petite media, and then petite frequency was counted directly from the plate. Promising extract for apoptosis stimulation on yeast cells is the 100 ppm Salam leaves extracts has petite frequency of 97.90%, whereas the 1000 ppm and 2000 ppm petite frequency are respectively 94.45% and 91.99%. No petite colony was formed on other extracts. Guava leaves extracts at 100 ppm inhibits apoptosis on yeast cells.
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Judul: Pengembangan daerah pantai utara Jawa Barat dalam rangka pembangunan regional
Abstrak: Indonesia sebagai salah satu negara yang baru berkembang, dalam pembangunan ekonominya banyak berorientasi pada aspek regional dimana peranan setiap wilayah atau daerah selain dilihat kepentingannya untuk masing-masing wilayah tersebut, juga dilihat peranannya terhadap wilayah lain yang secara keseluruhan berperan terhadap pembangunan nasional itu sendiri. Adanya aspek regional itu memang diperlukan untuk melengkapi serta menunjang pembangunan nasional dalam rangka pencapaian sasaran pembangunan baik untuk tujuan pemerataan hasil maupun tujuan efifiensi dari pada pembangunan itu sendiri. Pembangunan nasional dewasa ini dicirikan oleh adanya berbagai tujuan sebagaimana tersirat di dalam Garis-Garis Besar Haluan Negara, dimana tujuan-tujuan pembangunan nasional tersebut mencakup beberapa aspek yaitu aspek pertumbuhan ekonomi, aspek pemerataan dan aspek kesempatan kerja. Sejalan dengan tujuan pembangunan nasional tersebut maka pembangunan regional sebagai bagian integral dari pada pembangunan nasional, orien- tasinya juga harus memperhatikan aspek-aspek tujuan pembangunan nasional itu sendiri.
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