Judul: Inhibisi Ekstrak Air Lima Tanaman Obat terhadap Glikasi Protein secara In Vitro dan Potensinya sebagai Antipenuaan.
Abstrak: Potensi antipenuaan ekstrak air 5 daun tanaman obat, yaitu daun asam jawa (Tamarindus indica), daun jambu biji (Psidium guajava), daun kedawung (Parkia roxburghii), daun mangga (Mangifera indica), dan daun teh (Camellia sinensis) ditetapkan berdasarkan aktivitasnya sebagai antiglikasi dan antioksidan. Aktivitas antiglikasi dan antioksidanditentukan berdasarkan kemampuan menghambat glikasi protein danperedaman radikal2,2-difenil-1-pikrilhidrazil.Hasilnya, kelima ekstrak air memiliki daya inhibisi glikasi protein > 75% pada konsentrasi 500 μg/mL. Ekstrak yang paling berpotensi sebagai antipenuaan ialah ekstrak air daun mangga dan daun tehkarena memiliki aktivitas antiglikasi dan antioksidan yang paling efektif.Kedua ekstrak memiliki nilai IC50 terhadap glikasi protein sebesar 182 μg/mL (daun mangga) dan 213 μg/mL (daun teh), sekitar 10 kali kurang efektif dibandingkan aminoguanidin (IC5020 μg/mL). Sebagai antioksidan, kedua ekstrak memiliki nilai IC50 sebesar 9 μg/mL (daun mangga) dan 8 μg/mL (daun teh), sekitar 3 kali kurang efektif dibandingkan asam askorbat (IC503 μg/mL).
Keyword: advanced glycation end products, AGEs, antiglycation, oxidative stress

Judul: Antiglikasi Formula Ekstrak Air Daun Mangga (Mangifera indica) dan Daun Teh (Camellia sinensis).
Abstrak: Formulasi ekstrak air daun mangga dengan daun teh diawali dengan menentukan ekstrak daun mangga terbaik berdasarkan aktivitas antioksidan (metode DPPH) dan antiglikasinya (inhibisi glikasi protein). Sampel daun mangga yang digunakan adalah daun mangga manalagi, gedong, dan indramayu. Dari hasil penelitian didapatkan ekstrak daun mangga manalagi sebagai ekstrak daun mangga terbaik dengan IC50 antioksidan 11.20 μg/mL dan antiglikasi 224.61 μg/mL. Selanjutnya ekstrak daun mangga manalagi diformulasikan dengan ekstrak daun teh menggunakan SCD (simplex centroid design). Formulasi ekstrak meningkatkan aktivitas antiglikasi dan secara umum antioksidan memiliki hubungan yang positif dengan antiglikasi. Antioksidan terbaik terdapat pada formula E (ekstrak tunggal daun mangga manalagi) dengan nilai IC50 11.20 μg/mL, sedangkan antiglikasi terbaik terdapat pada formula D (ekstrak daun mangga manalagi:ekstrak daun teh sebesar 2:1) dengan nilai IC50 42.85 μg/mL.
Keyword: AGEs (advanced glycation end products), antiglikasi, antioksidan, antipenuaan, formulasi

Judul: Thermal Characteristics and Dynamics of Tropical Cyclone over Western North Pacific Ocean: A Case Study of Typhoon Songda (Chedeng) 2011
Abstrak: The frequent occasion of Tropical Cyclone (TC) over Western North Pacific (WNP) Ocean lies from 10˚N to 26˚N and 121˚E to 170˚E. Sources of TC development come from warm ocean temperature where latent heat is released during condensation processes and subsequently concentrated in the boundary layer. Relative humidity at 850-700 hPa is responsible to produce the most intense storm. Meanwhile, weak vertical wind shear between 850-200 hPa is one of the dynamical factors that lead to the development of TC. Pressure level of 850-200 hPa is chosen to minimize the thermodynamic effect in the lower troposphere. Typhoon Songda (Chedeng in the Philippines) or TSC lasted from May 18th to 30th, 2011 and strengthened into powerful Super Typhoon stage between May 24th and 27th. Long curving track and the exhibition of all sequences of TC life cycle, TSC is then considered as an ideal case of TC. The objective of the study with case of TSC is to investigate the role of thermal characteristics and dynamics on TC intensity. The research is carried out by using Advanced Research of Weather Research and Forecasting model (WRF ARW model) version 3.3. Two domains are employed in the model. The first domain situate from 02˚N to 40˚N and 118˚E to 149˚E and cover spatial resolution () of 33.1 km. The second domain situate from 09˚N to 27˚N and 119˚E to 132˚E with of 11 km. Timestep of the model () is 120 seconds. The model is supported by the following physical parameterization, i.e., Yonsei University Scheme (YSU) in the boundary layer, Kain-Fritsch scheme (KF) in the cumulus, and WRF Single-Moment 3-class scheme in the microphysics. Initial meteorological condition prior to the formation of the cyclone is generated using WRF ARW standard-release model. Sensitivity of the model output is obtained from a selected single-parameter change scenarios, namely, 10 % to 20 % decrease and increase of wind shear initial data at 850-200 hPa, and by 10 % to 20 % decrease of relative humidity initial data at 850-700 hPa. The result showed that the negative correlations between wind shear and intensity are found in wind shear scenarios. Wind shears of 10 ms-1 which lead to strengthening of the wind intensity in the early period of Typhoon development are found in wind shear scenarios. The effect of wind shear changes on wind intensity is statistically significant in the 20 % wind shear scenarios. During mature stage, weak wind intensity occurred when wind shear increase as given in the WRF standard-release and the 20 % decreasing scenario. Different situation is found in the 20 % increasing scenario where wind shear tend to weak and lead to strong wind intensity at this stage. Meanwhile, the reduction of moisture supply at 850-700 hPa resulting from 20 % decreasing relative humidity play a major role in the weakening of wind intensity and reduces mechanical energy of the cycle process as much as 300 J kg-1.
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