Judul: Pengaruh Kombinasi Ekstrak Daun Alpukat dan Akar Alang-alang pada Kadar Ureum dan Kreatinin Tikus Model Nefrolitiasis
Abstrak: Alpukat dan alang-alang merupakan tanaman herbal yang mengandung flavonoid, yang secara emipiris mampu mengatasi masalah nefrolitiasis. Penelitian ini bertujuan mengkaji pengaruh kombinasi ekstrak daun alpukat dan akar alang-alang pada kadar ureum dan kreatinin tikus yang diinduksi etilen glikol dan amonium klorida. Penelitian ini menggunakan 25 ekor tikus putih jantan galur Sprague-Dawley, dibagi menjadi 5 kelompok perlakuan yaitu normal (A), negatif (B), positif (C), kombinasi 1 (D), dan kombinasi 2 (E). Pengambilan darah dilakukan pada hari ke-14 dan hari ke-28. Kadar ureum dan kreatinin diperiksa dengan alat Semi Auto Chemistry Analyzer Mindray-BA-88A. Hasil penelitian menunjukkan kadar ureum kelompok kombinasi 1 lebih rendah (p<0,05) dibandingkan dengan kelompok negatif pada hari ke-28, sementara kadar kreatinin kelompok kombinasi 1 memiliki nilai yang rendah dan tidak berbeda nyata pada hari ke-14 dan ke-28. Berdasarkan hasil penelitian, dapat disimpulkan pemberian kombinasi 1 merupakan dosis terbaik pada penelitian ini dalam menurunkan kadar ureum dan mempertahankan kadar kreatinin pada tikus model nefrolitiasis., Avocado and reeds are herbal plants containing flavonoids, which can treat nephrolithiasis. This study examines the combination effect of avocado leaf extract and reed roots on urea and creatinine levels in rats induced by ethylene glycol and ammonium chloride. In this study, used 25 male white rats of the Sprague-Dawley strain were divided into 5 treatment groups, normal (A), negative (B), positive (C), combination 1 (D), and combination 2 (E). Blood sampling was conducted on the 14th and 28th day and checked using a Mindray-BA-88A Semi Auto Chemistry Analyzer machine. The results showed that the urea level in combination group 1 was lower (p<0.05) compared to the negative group on day 28th, while the creatinine level in combination group 1 had a low value and was not significantly different on 14th and 28th day. Based on the research results, it can be concluded that giving combination 1 is the best dose in this study in reducing urea levels and maintaining creatinine levels in nephrolithiasis model mice.
Keyword: antinephrolithiasis, reed roots extract, avocado leaf extract, creatinine levels, urea levels

Judul: Efek Nefroprotektif Kombinasi Ekstrak Daun  Alpukat dan Daun Kumis Kucing terhadap  Histopatologi Ginjal Tikus Putih yang Diinduksi  Etilen Glikol
Abstrak: Urolithiasis adalah salah satu penyakit yang sering ditemukan pada hewan kesayangan. Terapi di antaranya menggunakan obat tradisional daun alpukat (Persea americana Mill.) dan daun kumis kucing (Orthosiphon aristatus). Tujuan penelitian adalah mempelajari efek nefroprotektif kombinasi ekstrak daun alpukat dan kumis kucing melalui histopatologi ginjal. Sebanyak 25 ekor tikus putih Sprague Dawley umur 3-4 bulan bobot 200-300 g, dibagi menjadi lima kelompok perlakuan yaitu: kontrol normal (KO) diberi akuades, kontrol negatif (KN) diberi induser dan tidak diterapi; sediaan komersil (KP) diberi induser dan sediaan komersil, kelompok ekstrak 1 (K1) diberi induser dan kombinasi ekstrak daun alpukat 300 mg/kg BB dan daun kumis kucing 250 mg/kg BB, dan kelompok ekstrak 2 (K2) diberi induser dan kombinasi ekstrak daun alpukat 600 mg/kg BB dan daun kumis kucing 500 mg/kg BB. Larutan induser yang digunakan etilen glikol 0,75% dan amonium klorida 2%. Etilen glikol menginduksi pembentukan kristal di tubulus dengan bentuk serpihan ireguler. Lesio histologi yang ditemukan yaitu edema dan atrofi glomerulusan degenerasi hidropis, dilatasi, endapan protein di lumen dan nekrotik tuulus, sedangkan jaringan interstitial hemoragi. Kombinasi ekstrak daun alpukat dan kumis kucing bersifat nefroprotektif karena nilai rata-rata persentase lesio ginjal lebih rendah dibandingkan sediaan komersil, dan kombinasi K2 lebih baik dibandingkan K1. Ekstrak daun alpukat melindungi ginjal melalui flavonoid dan saponin sebagai antioksidan dan efek diuretikum pada daun kumis kucing., Urolithiasis is a disease that is often found in pets. Therapy includes using traditional medicine for avocado leaves (Persea americana Mill.) And cat whiskers leaves (Orthosiphon aristatus). This research aimed to study the nephroprotective effect of the combination of avocado leaf extract and cat's whiskers through kidney histopathology. A total of 25 Sprague Dawley rats aged 3-4 months weighing 200-300 g, were divided into five treatment groups, namely: normal control (KO) was given distilled water, negative control (KN) was given an inducer and not treated; commercial preparations (KP) were given an inducer and commercial preparations, extract group 1 (K1) was given an inducer and a combination of avocado leaf extract 300 mg/kg BW and cat whiskers leaf 250 mg/kg BW, and group extract 2 (K2) was given inducer and combination avocado leaf extract 600 mg/kg BW and cat whiskers 500 mg/kg BW. The inducer solution used 0.75% ethylene glycol and 2% ammonium chloride. Ethylene glycol induces the formation of crystals in the tubules in the form of irregular flakes. The histological lesions found were edema and glomerular atrophy, hydropic degeneration, dilation, lumen, and necrotic protein deposits in the tubules, while the interstitial tissue was hemorrhagic. The combination of avocado leaf extract and cat whiskers is nephroprotective because the average value of renal lesion percentage is lower than commercial preparations, and the combination of K2 is better than K1. Avocado leaf extract protects the kidneys through flavonoids and saponins as antioxidants and a diuretic effect on cat whiskers.
Keyword: daun alpukat, daun kumis kucing, etilen glikol, nefroprotektif

Judul: Development of IPB Linux Open Source Distribution for Business (ILOSbiz)
Abstrak: The objective of this research is to develop a Linux distribution, ILOSbiz, targeted for office use. This distribution is built through remastering another established distribution, similar to the previously developed ILOS in 2008. In order to know the needed applications to include in ILOSbiz, a survey was conducted involving 15 IPB staffs. We experimented with OpenSUSE and PCLinuxOS using KIWI Image System and My LiveCD to remaster, respectively. PCLinuxOS with My LiveCD was chosen for the final ILOSbiz as it gave better flexibility in the remastering. Comparison with ILOS shows that ILOSbiz has better hardware support.
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