Judul: Kapasitas Antioksidan dan Inhibisi Lipase Pankreas Hasil Fraksinasi Daun Kumis Kucing (Orthosiphon aristatus) secara In Vitro
Abstrak: Kumis Kucing (Orthosiphon aristatus) merupakan salah satu dari beberapa tanaman yang memiliki potensi sebagai agen antiobesitas. Penelitian ini bertujuan menguji efektivitas hasil fraksinasi daun kumis kucing sebagai agen antiobesitas berdasarkan kinerjanya dalam menghambat aktivitas lipase pankreas. Sampel diuji kadar airnya, kemudian diekstrak dengan etanol 70% menggunakan metode sonikasi dan dilanjutkan dengan fraksinasi bertingkat menggunakan empat pelarut dengan sifat kepolaran yang berbeda (n-heksana, kloroform, etil asetat, dan akuades). Hasil ekstraksi dan fraksinasi diuji fitokimia (fenolik, flavonoid, dan antioksidan) dan uji inhibisi terhadap lipase pankreas. Hasil penelitian menunjukkan seluruh fraksi dan ekstrak etanol 70% memiliki aktivitas inhibisi bahkan lebih besar dibandingkan dengan kontrol positifnya (orlistat). Fraksi yang memiliki persen inhibisi tertinggi adalah fraksi akuades dengan nilai 94,15%. Kumis kucing berpotensi sebagai agen antiobesitas. Namun perlu dilakukan uji lanjutan secara in vivo untuk membuktikan potensi dari tanaman ini lebih lanjut., Orthosiphon aristatus is one of the few plants which has the potential as antiobesity agent. This study aimed to measure the effectivity of frationation of its leaves as antiobesity agent based on its performance in inhibiting the activity of pancreatic lipase. Before extraction, the sample was tested for water content. The extraction was performed with sonication method and followed by multilevelled fractionation using four different solvents based on their polarity (n-hexane, chloroform, ethyl acetate, and aquades). Phytochemical (phenolic, flavonoid, and antioxidant) and pancreatic lipase inhibition assays were performed for both crude extract and fractions. The result showed all fractions and crude extract have higher ability to inhibit target enzyme than the control positive (orlistat). The inhibition activity of aquades fraction was 94,15% which was the highest value out of all the sample tested. As the results had been proven, the potential of Orthoshiphon aristatus as antiobesity must be investigated through in vivo assay in order to prove the effectivity.
Keyword: fraksinasi, lipase pankreas, inhibisi, Orthosiphon aristatus

Judul: Identifikasi Senyawa Aktif Daun Kumis Kucing (Orthosiphon aristatus) dengan LC-MS dan Potensinya sebagai Inhibitor Lipase Pankreas In Silico
Abstrak: Obesitas merupakan kondisi tubuh dengan penumpukan lemak berlebih yang menyebabkan tubuh mengalami kelebihan berat badan. Prevalensi obesitas di Indonesia dan dunia terus meningkat setiap tahunnya. Kumis kucing diketahui sebagai tanaman herbal yang berpotensi sebagai inhibitor lipase pankreas. Penelitian ini bertujuan mengidentifikasi senyawa aktif daun kumis kucing dengan LC-MS dan potensinya sebagai inhibitor lipase pankreas. Metode LC-MS digunakan untuk mengidentifikasi senyawa aktif dilanjutkan dengan penambatan molekuler menggunakan perangkat lunak YASARA. Hasil penelitian diperoleh 26 senyawa aktif dari ekstrak etanol 70% dan 12 ligan hasil studi literatur. Terdapat 14 senyawa yang berpotensi menjadi kandidat inhibitor lipase pankreas. Tiga senyawa menjadi kandidat terbaik inhibitor lipase pankreas, yaitu senyawa licoagroside A, tetramethylsutellarein serta satu senyawa penciri kumis kucing yaitu sinensetin, berdasarkan seluruh parameter uji., Obesity is a condition of the body with an excess of fat accumulation causing overweight. The prevalence of obesity in Indonesia and all over the world increases year by year. Cat’s whisker is known as herbal plant that has potential as pancreatic lipase inhibitor. This research aims to identify the active compounds of cat’s whisker leaves using LC-MS and its potential as a pancreatic lipase inhibitor. LC-MS method is used to identify the active compounds and followed by molecular docking with YASARA software. The result showed that there are 26 bioactive compounds from 70% ethanol extract and 12 bioactive compounds from literature study. There are 14 compounds, it’s can potentially become pancreatic lipase inhibitors. Licoagroside A, tetramethylscutellarein and sinensetin as one of the marker compound of cat’s whisker leaves are the most potential compounds as a pancreatic lipase inhibitor based on all parameters.
Keyword: antiobesity, cat's whiskers leaves, In Silico, pancreatic lipase

Judul: Dynamics Model for Rural and Urban Economic Growth
Abstrak: Lewis theory of structural change has focused on mechanisms that allow countries to transform their domestic economic structure to a more modern economy. The proposed model deals with the mechanism of interaction between rural and urban Economic. This model is concerned with the process of labor transfer from rural to urban areas. This study aims to model the dynamics of economic growth in rural and urban areas, including determining the equilibrium solution and to carry out simulation of the model. The simulation results show that the transfer of labor from rural to urban areas will increase the rate of change of capital so that structural changes can be realized. In addition, increased propensity to save in rural areas will also accelerate structural change
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