Judul: Pola Kepemimpinan Elit Desa dalam Perkembangan Masyarakat Pedesaan di Tiga Desa, Kecamatan Katikuna, Sumba Barat Nusa Tenggara Timur
Abstrak: Penelitian ini bertujuan untuk mengidentifi kasikan (a) posisi dan komposisi elit desa, (b) pola-pola kepemimpinan elit desa dan (c) faktor-faktor yang mempengaruhi pola kepemimpinan elit desa da7am konteks perubahan struktur kehidupan kolektif dan struktur kekuasaan di pedesaan Sumba; dan mengidentifikasi kan sampai seberapa jauh perubahan struktur kehidupan kolektif dan struktur kekuasaan tadi mempengaruhi pola kepemimpinan elit desa.
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Judul: Sistem Kepemimpinan dalam Pembangunan Masyarakat di Pedesaan Studi Kasus di Desa Durian Daun, Kecamatan Sungai Limau, Kabupaten Padang Pariaman, Propinsi Sumatera Barat
Abstrak: Tujuan dari penelitian ini adalah untuk mempelajari: (1) Sejarah sistem kepemimpinan masyarakat dan hubungannya dengan proses kemunculan pemimpin di Desa Durian Daun, (2) Profil dan gaya kepemimpinan yang tercermin dalam interaksi sosial antara pemimpin formal dengan pemimpin informal pada pelaksanaan fungsi dalam pembangunan masyarakat desa dan (3) Faktor-faktor yang medukung atau menghambat keberhasilan sistem kepemimpinan untuk menjalankan perananan mengembangka potensi dan swadaya masyarakat dalam pelaksanaan program pembangunan desa.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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