Judul: Aktivitas Alkalin Fosfatase Serum dan Gambaran Histopatologi Ginjal Tikus yang Diberi Kelapa Kopyor Pascainduksi Parasetamol
Abstrak: The aims of this research were to determine the effects of paracetamol induction and kopyor coconut consumption on the activity of alkaline phosphatase (ALP) and histophatology of rat kidney. These treatments were development of previous findings showing that paracetamol can cause negative effect to the body while kopyor coconut has the ability to improve human health, related with its capacity to prevent oxidative damage of human body. In this research, the positive effect of kopyor is approached through measurement of body weight, the activity of the ALP enzyme of test animals, anatomi pathology, and kidney histophatology. The result shows that paracetamol treatment using toxic dose was found to reduce body weight of test animals. Meanwhile, both kopyor and temulawak were able to counter the negative effect of paracetamol, indicated by the increase in the body weight of test animals. Other results showed that treatments using temulawak and kopyor of 3 time-dose demonstrated a positive effect on ALP serum activity in the kidney significantly as compared to negative control. Furthermore, pathologic observation of the test animals’ kidney showed that kopyor treatment of 3 time-doses was confirmed helping the kidney to recover from negative effect of paracetamol, better than the negative control.
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Judul: Uji aktivitas hepatoprotektor ekstrak air pegagan (Centella asiatica) terhadap tikus putih jantan yang diinduksi parasetamol
Abstrak: This study was undertaken to investigate activity of Centella asiatica extract against paracetamol induced liver damage in male Wistar albino rats. Rats were divided into five groups namely control (aquadest), herb extract with four formulations which were F 6, F 10, F 12, and F 16. Rats were administered paracetamol at dose 1000 mg/kg bw (p.o) as toxic dose for inducing hepatotoxicity. Herb extract in each formula was given at dose 1500 mg/kg bw (p.o) one hour after paracetamol administration. The treatment was given for eight days and blood was collected three times (before treatment, after paracetamol treatment, and last treatment) from tail artery and analysed for serum glutamate pyruvate transminase (SGPT). The hepatoxicity produced by acute paracetamol administration was found to be inhibited by Centella asiatica at group F 16 with evidence of decreased level of serum glutamate pyruvate transminase (SGPT) consentration. The hepatoprotective activity Centella asiatica was also supported by histopathological studies of hepatocytes
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Judul: Hamiltonian formulation for linear waves motion in two layers fluid
Abstrak: The surface wave could be considered as a wave that separates two fluids, namely water and air. Based on this assumption, it is introduced the interfacial wave, a wave between two layers of fluid with different density. The formulation of interfacial waves motion begins with deriving the base equation of irrotational ideal fluid. Furthermore, according to irrotational fluid assumption, the base equation can be stated in velocity potential. In this derivation, the fluids domain is assumed to be restricted by rigid lid boundary conditions, both at the upper and lower limit. Therefore, the interfacial waves motion can be explained in a hamiltonian formulation. In the hamiltonian formulation, total energy is defined as the sum of kinetic and potential energy. The hamiltonian system is obtained from reduction of kinetic energy by using the Dirichlet Neumann Operator. The resulted kinetic energy equation is nonlinear. Therefore, this form is linearized by first part of the Taylor expansion. This linearization gives a dispersion relation of linear wave. Based on this dispersion relation, the phase speed of the linear wave depends on the density ratio of the two layers fluid.
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