Judul: Potensi Antihiperglikemia Ekstrak Kulit Kayu Mahoni (Swietenia macrophylla King) pada Tikus yang Diinduksi Aloksan
Abstrak: Mahogany bark (Swietenia macrophylla King) contain active compound which have antihyperglycemic activity. This research was aimed at investigating the effect of mahogany bark on blood glucose concentration and histopathology in rat’s pancreas which induced alloxan. On this research Sprague-Dawley rats were divided into 5 groups, each group were 5 rats, A (NaCl 0.9% + aquades), B (aloxan + aquades), C (aloxan + Glibenclamide 0.25 mg/kg BW), D (aloxan + water extract of mahogany bark 250 mg/kg BW), and E (aloxan + metanol extract of mahogany bark 250 mg/kg BW). Blood glucose concentration defined by using Accu-Chek® Active glucometer. Pancreas histopathology analysis was carried out with Haematoxylin Eosin (HE) staining and observed under light microscope. Result showed water extract of mahogany bark can decrease blood glucose concentration from 173,2 mg/dL to 94 mg/dL (45,73%) and methanol extract of mahogany bark can decrease blood glucose concentration from 118,6 mg/dL to 88 mg/dL (25,80%). Result of histopathology showed there was improvement on pancreas gland. Methanol extract given better restoration effect on the islets of Langerhans than water extract
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Judul: Aktivitas Antioksidan dan Penghambatan α-Glukosidase Ekstrak dan Nanopartikel Ekstrak Kulit Kayu Mahoni (Swietenia macrophylla King)
Abstrak: Mahogany (Swietenia macrophylla King) bark is waste disposal industry manufacture of bark. Mahogany bark have catechin, epicatechin, and swietemacrophyllanin contents which useful as an antioxidants and antidiabetic of rats induced alloxan. This study aimed to determine the antioxidant activity and inhibition of α-glucosidase in the extract and nanoparticle extract of mahogany bark. Extraction method use aquades as solution, antioxidant activity assays was caried using 2,2-diphenyl-1-picrilhidrazyl (DPPH) and reducing power. Inhbition of α-glucosidase was measured with a spectrophotometric method. Mahogany moisture content was 4.87%. Extract yield of 9.46% and yield of nanoparticle 51.11% were obtained. The DPPH resulted that of the rutin compound, extract, and nanoparticles obtained by IC50 DPPH method sequentially 17.33 ± 1.17 ppm, 9.62 ± 0.72 ppm, and more than 2500 ppm. Respectively, power reduction of the rutin compound has a 67.03% at 25 ppm, the extract 67.41% at 20 ppm, and nanoparticle 31.47% at 20 ppm. IC50 values inhibition of α-glucosidase extract was 17.25 ppm, nanoparticles were more than 200 ppm, and acarbose was 0.37 ppm. The test results showed that the extract capable of acting as antioxidant and antidiabetic based on IC50 values. As for nanoparticles mahogany bark extract did not able to act as antioxidants and antidiabetics based on the method tested.
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Judul: Dinamika dan Faktor yang Memengaruhi Permintaan Tenaga Kerja Sektor Konstruksi di Indonesia
Abstrak: Ketersediaan infrastruktur merupakan landasan bagi pembangunan suatu negara. Salah satu sektor yang sangat berperan bagi pembangunan infrastruktur adalah sektor konstruksi. Namun walaupun sektor tersebut cukup memberikan andil yang besar terhadap pembangunan infrastruktur, kondisi ketenagakerjaan pada sektor konstruksi memperlihatkan penurunan jumlah pada tahun 2016-2017. Sehingga tujuan dari penelitian ini yaitu untuk menganalisis dinamika tenaga kerja sektor konstruksi serta faktor-faktor yang memengaruhi permintaan tenaga kerja sektor konstruksi di Indonesia. Metode yang digunakan dalam penelitian ini adalah model panel data. Analisa deskriptif dan kuantitatif digunakan untuk menganalisis dinamika tenaga kerja dan faktor-faktor yang memengaruhi permintaan tenaga kerja sektor konstruksi di Indonesia. Hasil penelitian ini menunjukkan bahwa seluruh variabel independen berpengaruh signifikan terhadap variabel dependen. Variabel PDRB sektor konstruksi berpengaruh positif terhadap permintaan tenaga kerja sektor konstruksi. Sedangkan variabel pengeluaran infrastruktur, pertumbuhan PDRB, dan upah sektoral riil berpengaruh negatif terhadap permintaan tenaga kerja sektor konstruksi di Indonesia.
Keyword: construction, infrastructure, labor dynamics