Judul: Keragaman Gen TP53INP1 dan Asosiasinya dengan Komposisi Asam Lemak Daging Domba
Abstrak: Gen TP53INP1 adalah salah satu gen yang terlibat dalam pengaturan metabolisme lemak dan memiliki keterkaitan dengan komposisi asam lemak pada domba. Penelitian ini bertujuan mengindentifikasi keragaman gen TP53INP1 dan asosiasinya dengan komposisi asam lemak daging domba lokal Indonesia. Total sampel yang digunakan sebanyak 130 sampel DNA ekor domba jantan yang terdiri dari 10 ekor domba barbados cross (DBC), 10 ekor domba compass agrinak (DCA), 20 ekor domba ekor gemuk (DEG), 53 ekor domba ekor tipis (DET), 10 ekor domba komposit garut (DKG), dan 27 ekor domba jonggol (DJG). Identifikasi keragaman gen TP53INP1|NlAIII menggunakan metode Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). Ukuran produk PCR yang teramplifikasi memiliki panjang basa sebesar 457 bp. Keragaman gen TP53INP1 ditemukan pada semua jenis sampel domba dengan genotipe AA, AG, dan GG. Frekuensi alel TP53INP1|NlAIII berada dalam keseimbangan Hardy-Weinberg kecuali pada domba ekor tipis (DET). Asosisiasi SNP gen TP53INP1 dengan asam lemak menggunakan uji T (P<0,05) pada domba yaitu asam palmitat (C16:0), asam behenat (C22:0), asam lignoserat (C24:0), asam palmitoleat (C16:1), asam elaidat (C18:1n9t), asam gondoat (C20:1), asam nervonat (C24:1), asam oleat (C18:1n9c), dan asam linolelaidat (C18:2n9t). Disimpulkan bahwa SNP gen TP53INP1 mempengaruhi komposisi asam lemak domba., TP53INP1 gene is one of the genes involved in regulating lipid metabolism and is related to the fatty acid composition of sheep. This study aims to identify the diversity of TP53INP1 gene and it’s association with the fatty acid composition of Indonesian local sheeps. The total sample used was 130 ram DNA samples consisting of 10 barbados cross (DBC), 10 agrinak compass sheep (DCA), 20 javanese fat tailed (DEG), 53 javanese thin tailed (DET), 10 garut composite sheep (DKG), and 27 jonggol sheep (DJG). Identification of the diversity of TP53INP1|NlAIII was identified by the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method. The amplified PCR product had 457 bp. The diversity of the TP53INP1 gene was found in all types of sheep samples with the genotypes AA, AG, and GG. The allele frequency was in Hardy-Weinberg equilibrium except for the thin tailed sheep (DET). SNP TP53INP1 gene used the T test was associated (P<0,05) with fatty acids in sheeps, such as palmitic acid (C16:0), behenic acid (C22:0), lignoceric acid (C24:0), palmitoleic acid (C16:1), elaidic acid ( C18:1n9t), gondoic acid (C20:1), nervonic acid (C24:1), oleic acid (C18:1n9c), and linolelaidic acid (C18:2n9t). It could be concluded that the SNP TP53INP1 gene effects to the fatty acid composition of lamb.
Keyword: TP53INP1 gene, fatty acids, PCR-RFLP, sheep

Judul: Characterization of DGAT1 Gene as Candidate Marker for Quality and Nutrition of Indonesian Sheep
Abstrak: Kualitas daging domba premium melalui peningkatan nilai gizi yang terkandung dalam daging melalui potensi gen diacylglycerol acyltransferase-1 (DGAT1). Penelitian ini bertujuan mengidentifikasi keragaman gen DGAT1 pada SNP g.8539 C>T serta kaitannya dengan perbaikan kualitas dan gizi (flavour dan odour, asam lemak, kolesterol, mineral, dan karakteristik karkas) daging domba Indonesia. Total sampel domba yang digunakan keragaman gen DGAT1 254 sampel berumur 10–12 bulan dengan jenis kelamin jantan yang terdiri dari domba ekor gemuk (DEG) (n=20), domba ekor tipis (DET) (n=107), domba komposit garut (DKG) (n=10), domba compass agrinak (DCA) (n=10), domba barbados cross (DBC) (n=10), domba garut (DG) (n=20), domba jonggol (DJ) (n=27) dan domba lokal jambi (DLJ) (n=50). 100 sampel digunakan untuk asosiasi gen DGAT1 terhadap flavour dan odour, asam lemak, kolesterol, mineral, dan karakteristik karkas. Identifikasi keragaman DGAT1|ALuI dianalisis dengan metode PCR-RFLP. Hasil keragaman gen DGAT1 bersifat polimorfik dalam DET, DG, dan DEG, sedangkan DCA, DBC, DLJ, dan DKG bersifat monomorfik. Dua genotipe CC, dan CT ditemukan dalam DET, DG, dan DEG. Titik mutasi gen DGAT1 berasosiasi (P<0.05) pada flavour dan odour, asam lemak sedangkan titik mutasi gen DGAT1 tidak berasosiasi (P>0.05) pada kolesterol, mineral, dan karakteristik karkas. Gen DGAT1 memiliki kontribusi dalam flavour dan odour yaitu pada senyawa 4-Ethyloctanoic acid (EOA) serta pada konten lemak, asam palmitoleat, dan asam heptadekanoat, The quality of premium sheep meat through improving the nutritional value contained in the meat through the potential gene diacylglycerol acyltransferase-1 (DGAT1). This study aims to identify the diversity of the DGAT1 gene with SNP g.8539 C>T access number EU178818 and its relationship to the quality and nutritional value (mineral, cholesterol, flavour and odour, fatty acids, and carcass characteristics) of Indonesian sheep. A total of 254 samples and ages 10-12 months, consisted of javanese fat-tail sheep (JFTS) (n=20), javanese thin-tail sheep (JTTS) (n=107), garut composite sheep (GCS) (n=10), compass agrinak sheep (CAS) (n=10), barbados cross sheep (BCS) (n=10), garut sheep (GS) (n=20), jonggol sheep (JS) (n=27), and jambi local sheep (JLS) (n=50). 100 samples use association DGAT1 gene with mineral, cholesterol, flavour and odour, fatty acid, and characteristic carcass. The diversity of DGAT|AluI were analyzed with PCR-RFLP method. DGAT1 gene were polymorphic in JTTS, GS, and JFTS, and monomorphic in CAS, BCS, JLS, and GCS sheep population. Two type genotypes CC and CT were found in JTTS, GS, and JFTS. SNP g.8539 C>T in DGAT was associated to flavour and odour (P<0.05), and fatty acid, but it was not associated to cholesterol, mineral, and characteristic carcass. DGAT1 gene has contribution to level of flavour and odour through stimulate 4-Ethyloctanoic acid (EOA) molecules and fat content, palmitoleac acid, and heptadecanoat acid.
Keyword: sheep, DGAT1 gene, mineral, cholesterol, flavour and odour, fatty  acid, characteristic carcass, PCR-RFLP.

Judul: Bifurkasi Hopf pada Model Siklus Bisnis Kaldor Kalecki tanpa dan dengan Waktu Tunda
Abstrak: Business cycle model is one of dynamical system models in economic. One of the business cycles model is Kaldor-Kalecki model. Kaldor-Kalecki business cycle model that is written in delayed defferential equations, is a business cycle model that involves gross product and capital stock of a company. In this paper Kaldor-Kalecki business cycle model is analyzed using both nondelay and delay in time of capital stock. By Taylor expansion for the time delayed model, an analysis of stability around the fixed points has been done. Furthermore, by using Hopf bifurcation theorem, it can be shown that there exists periodic orbits and limit cycle. In the nondelayed model, changing the parameter of goods market could lead to the occurrence of Hopf bifurcation and the existence of limit cycle. Similarly, for the delayed model, it has been shown that changing the time delay parameter may result in the occurrence of Hopf bifurcation and limit cycle.
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