Judul: Study In Silico Potential of Papaya Leaves  (Carica papaya L.) as an Immunomodulator Through Interleukin 6 Inhibition
Abstrak: Interleukin 6 dapat memberikan efek sebagai proinflamasi melalui aktivasi trans-signaling sehingga memperparah anjing yang terkena inflammatory bowel disease. Penghambatan interleukin 6 pada sisi aktifnya berpotensi menjadi alternatif pengobatan kasus IBD. Daun pepaya diketahui mengandung senyawa aktif yang memiliki aktivitas sebagai imunomodulator. Penelitian ini bertujuan memprediksi potensi senyawa aktif daun pepaya sebagai inhibitor interleukin 6 menggunakan metode in silico dengan azathioprine sebagai ligan pembanding. Sebanyak lima senyawa yaitu myricetin, cycloartenol, quercetin, kaempferol, dan chlorogenic acid melalui analisis bioavailabilitas dan toksisitas sebelum dilakukan penambatan molekuler. Kelima ligan uji memiliki nilai ?G lebih negatif dibandingkan ligan pembanding dan berikatan pada sisi aktif. Senyawa myricetin menunjukkan hasil penambatan terbaik dengan energi afinitas 6,6 kkal/mol dan pembentukan ikatan hidrogen pada semua sisi aktif, sehingga myricetin berpotensi sebagai inhibitor interleukin 6., Interleukin 6 can be proinflammatory through the activation of transsignaling, thus aggravating dogs affected by inflammatory bowel disease. Inhibition of interleukin 6 on the active site has the potential to be an alternative treatment for IBD cases. Papaya leaves are known contain active compounds that have activity as immunomodulators. This study aims to predict the potential of active compounds in papaya leaves as inhibitors of interleukin 6 using the in silico method with azathioprine as comparator ligand. A total of five compounds, namely myricetin, cycloartenol, quercetin, kaempferol, dan chlorogenic acid were used through bioavailability and toxicity analysis before molecular docking. All of ligand has a more negative ?G value compared to reference ligand and binds to the active site. Myricetin shows the best docking results with an affinity energy of 6.6 kcal/mol and formation of hydrogen bond on all active sites, so that myricetin has potential as an inhibitor of interleukin 6.
Keyword: In silico, daun pepaya, imunomodulator, inflammatory bowel disease, interleukin 6

Judul: Anti-inflammatory Activity of Active Compounds in Iler Leaves (Plectranthus scutellarioides) through In Silico Inhibition of Cyclooxygenase-2
Abstrak: Osteoarthritis (OA) adalah penyakit peradangan pada sendi yang diakibatkan kerusakan pada bantalan sendi yang diiringi dengan berkurangnya cairan sinovial. Penyakit ini termasuk penyakit degeneratif yang sering terjadi pada hewan dan mengiringi proses penuaan. Pengobatan diutamakan untuk mengurangi rasa nyeri dan tingkat peradangan. Oleh karena itu, diperlukan obat herbal sebagai alternatif untuk penanganan penyakit tersebut. Iler (Plectranthus scutellarioides) memiliki senyawa aktif anti-inflamasi. Penelitian ini bertujuan menguji senyawa aktif daun Iler yang berpotensi sebagai anti-inflamasi melalui inhibisi siklooksigenase-2 secara in silico (PDB ID 3LN1). Penelitian ini menggunakan software AutoDock Vina, dengan parameter sebagai berikut: energi bebas, konstanta inhibisi, dan nilai binding site similarity (BSS). Hasil dari penelitian menunjukkan hasil antosianin dan asam rosmarinat merupakan ligan uji yang memiliki nilai energi bebas yang terbaik, yaitu -9,6 kkal/mol dan -9,3 kkal/mol. Berdasarkan parameter tersebut dapat disimpulkan secara in silico senyawa aktif daun Iler berpotensi efektif untuk obat anti-inflamasi., Osteoarthritis (OA) is an inflammatory disease of the joints caused by damage to the joint cushions accompanied by reduced synovial fluid. This disease is a degenerative disease that often occurs in animals and accompanies the aging process. Treatment is prioritized to reduce pain and inflammation levels. Therefore, herbal medicine is needed as an alternative for treating this disease. Iler (Plectranthus scutellarioides) has an active anti-inflammatory compound. This study aims to examine the active compounds of Iler leaves which have potential as anti-inflammatory through in silico inhibition of cyclooxygenase-2 (PDB ID 3LN1). This study used AutoDock Vina software, with the following parameters: free energy, inhibition constants, and binding site similarity (BSS) values. The results of the study showed that anthocyanin and rosmarinic acid were the test ligands that had the best free energy values, namely -9,6 kcal/mol and -9,3 kcal/mol. Based on these parameters, it can be concluded that in silico the active compounds of Iler leaves are potentially effective for anti-inflammatory drugs.
Keyword: anti-inflamasi, Iler, penambatan molekuler, siklooksigenase-2

Judul: Rancang Bangun Pendeteksi Otomatis Ketinggian Permukaan Air Berbasis Sensor Medan Magnet UGN3503
Abstrak: An automatic detector of water level with sensor UGN3505 as detector of changes water level has been successfully be made for this research. Sensor UGN3505 is a hall effect sensor which works based on the large magnetic fields on the surface. The output voltage generated by the sensor without the influence of a magnetic field is 2,525 volts, the output voltage is different than it should be 0.025 volts is 2.50. This shows that the sensor is not completely free from magnetic field sources, there is still the effect of the Earth's magnetic field to the sensor. Sensor output voltage will increase, with increasing magnetic field on the surface of the sensor. As the central data processing equipment, used microcontroller ATmega16. The input of microcontroller is the changes output voltage of sensor than has been converted into digital data (internal ADC ATmega16) caused the changes of magnetic field. The digital data are readable by microcontroller be processed and displayed in the 16x2 LCD, LED indicator and buzzer. Programs created using software tools CVAVR with C + + language.
Keyword: Sensor UGN3505, magnetic field, hall effect, CVAVR, ATMega16, DC