Judul: Gambaran Toksikopatologi Organ Hati dan Ginjal Mencit C3H Pasca Pemberian Capsaicin
Abstrak: Capsaicin is the mayor compound founds in chilli peppers of the Capsicum genus. Capsaicin has been shown to have antiproliferative activity to intestine, liver, prostate, and leucocytes cancer cells in vitro. The liver and kidney are the main target of toxic effect. The research was conducted to know the effect of capsaicin to liver and kidney toxicopathology of C3H mice. Twelve mice strain C3H were divided into 3 groups. Groups 1 as a negative control were not administered capsaicin. Groups 2 were administered capsaicin for 2 weeks. Groups 3 were administered capsaicin for 4 weeks. The capsaicin was administered perorally with 10 mg/kgBW dose. Clinical observations made throughout the treatment period. Then, the mice euthanized and their organs were observed and preparated for histopathology stained hematoxylin-eosin (HE) and immunohistochemistry (CPI) using TNF-α antibody. The gross anatomy and histopathology showed that the mice treated capsaicin for 2 weeks showed average damage to the liver and kidney, while mice treated capsaicin for 4 weeks suffered severe damage to the liver and kidney. This shows the lack of security levels of capsaicin to the liver and kidneys.
Keyword: toxicopathology, liver, kidney, C3H mice, capsaicin, Bogor Agricultural University (IPB)

Judul: Kajian Toksikopatologi Pemberian Capsaicin Peroral terhadap Organ Lambung dan Usus Mencit C3H
Abstrak: Capsaicin is an active compound grouped in capsaicinoid in pepper plants. Capsaicin has many pharmacologic effect including cluster headcache therapy, postherpetic neuralgia, chronic pain, arthritis, diabeticneuropathic pain, and against a wide variety of tumor and cancer cells. The researcch was conducted to identify toxic effect of stomach and intestine that can be caused by capsaicin administered orally. Twelve mice straint C3H were divided into three groups: groups K1 (control), groups K2 (2 weeks treatment), and groups K3 (4 weeks treatment). Capsaicin was administered perorally for 2 weeks in K2 and 4 weeks in K3. The mice was necropsed, then the stomach and intestine were fixed in Buffer Neutral Formalin (BNF) for histopathological preparation. The results showed that capsaicin causes congestion, infiltration of inflammatory cell, and epithelium desquamation of the stomach and intestines. Based on these results, oral capsaicin is not safe for stomach and intestine.
Keyword: toxicopathology, stomach, C3H mice, capsaicin, Bogor Agricultural University (IPB)

Judul: Hamiltonian formulation for linear waves motion in two layers fluid
Abstrak: The surface wave could be considered as a wave that separates two fluids, namely water and air. Based on this assumption, it is introduced the interfacial wave, a wave between two layers of fluid with different density. The formulation of interfacial waves motion begins with deriving the base equation of irrotational ideal fluid. Furthermore, according to irrotational fluid assumption, the base equation can be stated in velocity potential. In this derivation, the fluids domain is assumed to be restricted by rigid lid boundary conditions, both at the upper and lower limit. Therefore, the interfacial waves motion can be explained in a hamiltonian formulation. In the hamiltonian formulation, total energy is defined as the sum of kinetic and potential energy. The hamiltonian system is obtained from reduction of kinetic energy by using the Dirichlet Neumann Operator. The resulted kinetic energy equation is nonlinear. Therefore, this form is linearized by first part of the Taylor expansion. This linearization gives a dispersion relation of linear wave. Based on this dispersion relation, the phase speed of the linear wave depends on the density ratio of the two layers fluid.
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