Judul: Aktivitas Antioksidan Superoksida Dismutase Pada Hati Tikus Hiperkolesterolemia Yang Diberi Ekstrak Kulit Mahoni (Swietenia macrophylla)
Abstrak: Mahoni’s stem bark is wood industrial waste that rich in secondary metabolites. Research about its antioxidant potency has been done previously. This research was performed to study about the mahoni’s bark extract mechanism on lowering lipid peroxidation by determining the activity of endogenous antioxidant in the liver. Thirty five male rats were divided into 5 groups (n=7) normal, hypercholesterolemic, lovastatin, extract 1, and extract 2 group. Normal group fed with standard rat chow, hypercholesterolemic group (HK) with cholesterol chow (1,5%) and PTU (0,5 mg/KgBW), lovastatin group (HK + lovastatin 0,2857 mg/KgBW), E1 group (HK+ mahoni extract 4,2 mg/KgBW), and E2 group (HK + mahoni extract 21 mg/KgBW). Experiments were carried out for 8 consecutive weeks. The rat liver superoxide dismutase (SOD) antioxidant activity were determined by calculating the inhibition percentage of pyrogallol autooxidation process became purpurogallin by SOD, total formed purpurogallin was measured using spectrophotometer with 340 nm wavelength. The SOD antioxidant activities in normal group of rats was 47.96±12.37%. There was not any significant SOD antioxidant activities difference between all rats group of treatment (=0.05). These result showed that mahoni’s bark extract roles as antioxidant in rats was achieve not by increasing the activity of superoxide dismutase but by other mechanism.
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Judul: Analisis Lipid Peroksida Hati Tikus Hiperkolesterolemia Pasca Terapi Ekstrak Kulit Kayu Mahoni
Abstrak: Mahogany (Swietenia macrophylla King.) bark contains bioactive compounds which are efficacious as antioxidant. Several in vitro studies on antioxidant activity have been carried out previously. However, there is no evidence about the effectiveness of antioxidant activity against lipid peroxidation in liver hypercholesterolemic rat. The aim of this research was to determine the effect of water extract of mahogany bark againist lipid peroxidation by analyzing the lipid peroxide of hypercholesterolemic rats liver. Thirty one male rats were divided into two parts, six were pre-treatment rats and the rest were treatment rats. The latter groups were divided into 5 groups. One normal group fed with standard rat diet and four treatment groups fed with cholesterol diet (1.5%) and propil tiouracil (PTU) (0.5 g/kg bw) during 6 weeks. Positive control group of treatment induced lovastatin (0.2875 mg/kg bw), 1st dose extract (E1) group (150 mg/kg bw), and 2nd dose extract (E2) group (300 mg/kg bw), respectively, during a week. Antioxidant activity of lipid peroxide in the liver were measured with thiobarbituric acid (TBA) assay using spectrophotometer. The diet of hypercholesterolemia 1.5% and PTU as long as 6 weeks increased lipid peroxide concentration of liver pre treatment 141.00%, significantly (p=0.032). Therapy of E1 and E2 tend to decrease lipid peroxide concentration of liver 20.95% and 15.54%. Statistically two doses of the extracts were not significantly different (p> 0.05).
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Judul: Implementation of Spatio-Temporal Change Query in Relational Database.
Abstrak: Geographic object changes in various views. Object changes are recorded using a model of static storage. No historical connection between old version data and new version data has been built. For that, a storage model of spatio-temporal queries that can analyze spatio-temporal changes has been developed. The object changes the geometry are grouped according to the taxonomy of Spatio-Temporal Pattern Change. This research has been able to apply the query patterns change including born, expand, merge, contract, split, normal and die. This query based on geometric (area) changes. The implementation of spatio-temporal change queries represents an object changes continuously with easy, change detection is done by comparing two versions of data. Keyword: spatio-temporal change query, spatio-temporal change pattern.
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