Judul: Kajian Spasial Kualitas Lingkungan Fisik Perumahan (Studi Kasus Kabupaten Bekasi)
Abstrak: Kajiankualitas Iingkungan fisik perumahan sampai saat ini umumnya masih mengandalkan data statistik dan kurang melibatkan aspek spasial. Aspek spasial belum mendapat porsi perhatian utama sebagai variabel penting dan berpengaruh untuk menilai kualitas Iingkungan fisik perumahan. Disisi lain hubungan antara karakteristik spasial, kawasan perumahan dan kualitas lingkungan perumahan merupakan hubungan segitiga yang saling mempengaruhi satu dengan lainnya. Penelitian ini mengkaji peranan dan pengaruh aspek spasial terhadap tingkat kualitas lingkungan fisik perumahan. Data penginderaan jauh resolusi sangat tinggi Ikonos diterapkan untuk memperoleh data variabel spasial perumahan. Sedangkan tingkat kualitas lingkungan fisik perumahan dinilai berdasarkan modifikasi pedoman Departemen Kebaikan Republik Indonesia No: 29NIYI999 dan Dircktorat Cipta Karya Departemen PekeIjaan Umum tabun 1986 tentang pesyaratan Iingkungan perumahan
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Judul: Dinamika Perkembangan
Wilayah dan Dampaknya terhadap Kualitas Lingkungan di Kabupaten Bekasi.
Abstrak: Perkembangan wilayah merupakan hasil dari upaya pengembangan wilayah yang bertujuan untuk mencapai kesejahteraan masyarakat dengan memanfaatkan berbagai sumber daya alam, sumber daya manusia, sumber daya kelembagaan, sumber daya teknologi dan prasarana fisik secara efektif. Namun, perkembangan wilayah yang khususnya diikuti dengan perubahan penggunaan dan tutupan lahan dapat berdampak buruk pada kualitas lingkungan. Tujuan dari penelitian ini (1) menganalisis perubahan tutupan lahan terutama persentase lahan terbangun, (2) menganalisis ketersediaan infrastruktur perkecamatan, (3) menghitung indeks kualitas lingkungan dan (4) mengkaji pengaruh perkembangan wilayah terhadap kualitas lingkungan di Kabupaten Bekasi. Data yang digunakan berasal dari data Potensi Desa dan dokumen dalam angka Kabupaten Bekasi tahun 2019 dan 2022. Penelitian ini dilakukan dengan metode overlay peta tutupan lahan, analisis skalogram dan tipologi klassen. Hasil penelitian menunjukkan bahwa tutupan lahan paling banyak berubah menjadi lahan terbangun yakni sebesar 7.287,55 ha. Indeks Perkembangan Kecamatan (IPK) cenderung mengalami peningkatan secara keseluruhan di Kabupaten Bekasi dari 9,7 ke 10,43. Indeks Kualitas Lingkungan (IKL) cenderung mengalami penurunan secara keseluruhan di Kabupaten Bekasi dari 10,49 ke 7,57. Analisis tipologi Klassen antara IKL dengan IPK menunjukkan bahwa wilayah kecamatan di Kabupaten Bekasi paling banyak berada pada kuadran II (IKL tinggi dan IPK rendah) pada kedua titik tahun yaitu masing-masing sebanyak 39,13% di tahun 2019 dan 34,78% di tahun 2022. Perbandingan antara IKL dengan persentase lahan terbangun menunjukkan bahwa di tahun 2019 wilayah kecamatan paling banyak berada pada kuadran II (IKL tinggi dan persentase lahan terbangun rendah) sebesar 34,78%, sedangkan di tahun 2022 paling banyak berada pada kuadran III (IKL dan persentase lahan terbangun rendah) yaitu sebesar 34,78%. Kata kunci: Perkembangan kecamatan, infrastruktur, tutupan lahan, lahan terbangun, lingkungan, Regional expansion is the result of regional development efforts which aim to achieve community welfare by utilizing various natural resources, human resources, institutional resources, technological resources and physical infrastructure effectively. However, regional development, especially accompanied by changes in land use and cover, can have a negative impact on environmental quality. The objectives of this research are (1) to analyze changes in land cover, especially the percentage of built-up land, (2) to analyze the availability of sub district infrastructure, (3) to calculate the environmental quality index and (4) to examine the influence of regional development on environmental quality in Bekasi Regency. The data used comes from village potential data and documents in Bekasi Regency figures for 2019 and 2022. This research was carried out using the land cover map overlay method, scalogram analysis and klassen typology. The research results show that the most land cover has changed to built-up land, namely 7287.55 ha. The District Development Index (DDI) tends to increase overall in Bekasi Regency from 9,7 to 10,43. The Environmental Quality Index (EQI) tends to decrease overall in Bekasi Regency from 10,49 to 7,57. Klassen typology analysis between EQI and DDI shows that most sub-district areas in Bekasi Regency are in quadrant II (high EQI and low DDI) at both points in the year, namely 39,13% in 2019 and 34,78% in 2022. Comparison between EQI and the percentage of built up area shows that in 2019 the most sub-district areas were in quadrant II (high EQI
Keyword: Regional development, infrastructure, built-up area, environment

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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