Judul: Uterine Tumors in Rabbit and Guinea Pig: A Histopathological and Immunohistochemical Study
Abstrak: Evaluasi histopatologi dan imunohistokimia dilakukan pada enam kasus adenokarsinoma uterus kelinci, tiga kasus leiomiosarkoma uterus kelinci serta satu kasus berupa adenoma dan leiomiosarkoma pada uterus marmut. Pola pertumbuhan tubulopapilari sangat umum terbentuk pada adenokarsinoma. Adenoma uterus, yang sangat jarang terjadi pada hewan domestik, cenderung membentuk pola pertumbuhan papilari. Penggunaan cytokeratin (CK) AE1/AE3, CK 19, CK 6, CK 15, E-cadherin, N-cadherin, vimentin, α-smooth muscle actin (α-SMA), desmin, dan calponin dievaluasi untuk merintis pemeriksaan imunohistokimia yang baik terhadap tumor uterus. Mayoritas sel-sel epitel neoplastik mengekspresikan CK AE1/AE3, CK19 dan E-cadherin, sedikit sel neoplastik mengekspresikan vimentin. Penggunaan AE1/AE3, CK 19, E-cadherin, dan vimentin disarankan dalam mendiagnosis tumor epitel. Sel otot neoplastik mengekspresikan α-SMA, desmin dan calponin. Calponin, yang menunjukkan ekspresi paling konsisten, disarankan untuk digunakan sebagai marker untuk mendiagnosis spindle-shaped sarcoma pada kelinci
Keyword: histopatologi, imunohistokimia, tumor uterus, kelinci

Judul: Studi Kasus Tumor Kelenjar Hipofise pada Tikus
Abstrak: The development of pituitary tumors in small rodents is a grievous and irreversible pathological condition. Detecting pituitary tumors is difficult, frequently resulting in a late-stage diagnosis or even post-mortem detection. Notably, there is a lack of literature on this tumor in Indonesia. This study aims to enhance our comprehension of pituitary tumors in rats by investigating their pathomorphological characteristics. The research methodology entails obtaining organ samples, such as the pituitary gland, kidney, and cerebellum, from euthanized rats afflicted with pituitary tumors. Grossly, the tumor looks like a small mass at the base of the brain, measuring 0.5 cm in size. Subsequently, histopathological preparations are performed using hematoxylin-eosin (HE) staining, enabling examination under a light microscope. Parameters evaluated include the growth patterns of proliferative lesions, cellular pleomorphism, and atypia. Histological findings indicate that the pituitary gland comprises hyperplastic, chromophobic tumor cells arranged diffusely, displaying anisokaryotic nuclei. Occasionally, mitotic figures have been observed. The absence of kidney and cerebellum abnormalities suggests the absence of tumor metastasis. This pituitary tumor is conclusively classified as a nonfunctional chromophobe adenoma.
Keyword: pituitary tumor, pituitary gland, rat, histopathology

Judul: Anthropogenic CO(2) contain in Indonesian Throughflow Region (ITF)
Abstrak: This research uses TrOCA method in order to investigate anthropogenic CO2 distribution in the Indonesian Throughflow (ITF) regime as well as its relationship with water mass transport from Pasific Ocean to Indian Ocean, based on four parameters; TCO2 (dissolved inorganic carbon), TA (total alkalinity), O2 (oxygen), and θ (potential temperature). The calculated anthropogenic CO2 is generaly distributed in upper layer of thermocline from both oceans, with concentration of 20–50 μmol.kg-1. In the North Equatorial Current (NEC) station section (section P10N) of Pacific Ocean, the anthropogenic CO2 is mainly stratified in upper layer with maximum concentration of 50 μmol.kg-1 and founded near surface. The anthropogenic CO2 content in NEC will be transported to Mindanao Current (MC) regime which is an inflow for ITF. Two stations in MC regime showed a similar stratification of anthropogenic CO2 in upper layer with maximum concentration of about 50 μmol.kg-1. In the outlet of ITF, particularly station section along eastern Indian Ocean (section H_I10), the stratification is still found in upper layer with maximum concentration of 50 μmol.kg-1. In section H_I10 on the eastern of Indian Ocean, concentration along latitude and longitude line are higher than the stations in western of Pasific Ocean. The estimation of anthropogenik CO2 budget in outlet ITF is 40.43–73.38 Tg C y-1, higher than those observed in inlet ITF is 13.88–33.72 Tg C y-1. It means that the ITF region is responsible for this different. In station of Banda and Ombai Strait, a high accumulation anthropogenic CO2 was found between 20-71 μmol.kg-1 in the depth ranging from 5 to 200 m. In Banda station, this accumulation was probably due to water mass transport from Java Sea, resident time and acccumulation of water, whereas in Ombai Strait station, it was because of water mass transport from Java Sea and Pacific Ocean, and terrestrial run off.
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