Judul: Perkembangan Terkini dari Inovasi Model Bisnis Berkelanjutan: Tinjauan Literatur Sistematis
Abstrak: The digital transformation in the fourth industrial revolution (Industry 4.0) disrupts the entire industry system and forces the industry to innovate by shifting the traditional business model to business model innovation that enables sustainable development. However, research suggests that business progress of sustainable business model innovation; the subsets of business model innovation, is lagging behind. Despite the growth of literature on the topic, the bridges between conceptualization and implementation are relatively unexplored. This study provides a comprehensive review of sustainable business model innovation through a systematic literature review. Its key contributions are: (1) a review of the development of the concept by pointing out the evolution of definitions, also key components, and frameworks or tools identification; (2) a factor identification through barriers and drivers; and (3) an acknowledgment of the roles of sustainable business model innovation in the implementation of sustainable business model., Transformasi digital pada era revolusi industri 4.0 mendisrupsi seluruh sistem industri dan memaksa industri untuk berinovasi dengan mengalihkan model bisnis tradisional ke inovasi model bisnis yang memungkinkan perkembangan berkelanjutan. Namun, penelitian menyatakan bahwa kemajuan bisnis dari salah satu bagian inovasi model bisnis, yaitu inovasi model bisnis berkelanjutan masih tertinggal. Meskipun terdapat pertumbuhan literatur tentang topik ini, jarak antara konseptualisasi dan implementasi tentang topik ini relatif belum tereksplorasi. Studi ini menyajikan reviu menyeluruh tentang inovasi model bisnis berkelanjutan melalui tinjauan literatur yang sistematis. Kontribusi utama studi ini adalah: (1) tinjauan pengembangan konsep dengan menunjukkan evolusi definisi, mengidentifikasi komponen utama, dan kerangka kerja atau alatalat; (2) identifikasi faktor melalui hambatan dan pendorong; serta (3) pengakuan peran dari inovasi model bisnis berkelanjutan dalam penerapan model bisnis berkelanjutan.
Keyword: sustainable business model, sustainable business model innovation, systematic literature review

Judul: The Development of Social Enterprise Reference Business Model in Indonesia: Systematic Literature Review.
Abstrak: Terdapat kesadaran baru mengenai humanisasi dalam era industri 5.0 yang disebabkan oleh kegagalan pasar, kegagalan pemerintah, dan kegagalan etika bisnis. Usaha sosial yang merupakan entitas dengan tujuan mengatasi permasalahan pelayanan publik dengan menggunakan fungsi bisnis menjadi faktor pendukung dalam mewujudkan revolusi industri 5.0 dan pembangunan berkelanjutan di Indonesia. Penelitian ini bertujuan untuk menyusun sebuah rekomendasi berupa model bisnis yang tepat untuk dapat diimplementasikan di Indonesia dengan didasarkan oleh hasil identifikasi praktek terbaik dari Korea Selatan dalam konteks usaha sosial serta komparasinya terhadap faktor eksternal aktual yang terjadi di Indonesia. Analisis deskriptif terhadap studi komparasi faktor eksternal dan model bisnis dilakukan menggunakan alat analisis PESTLE (Political, Economic, Social, Technology, Legal, Environment) dan tipologi model bisnis Alter 2017. Penelitian menghasilkan dua rekomendasi model bisnis yang diajukan yaitu Independent Social Movement Business Model of Social Enterprises dan Integrated – External Mixed Business Model of Social Enterprise., A modern awareness of humanization occurs within the Industry 5.0 period caused by market failures, government failures, and business ethics failures. A social enterprise, entities with the point of overcoming public service problems using business functions, is critical in realizing the 5.0 industrial revolution and sustainable development in Indonesia. This study aims to formulate a suggestion in the form of a business model to be actualized in Indonesia based on the distinguishing proof of benchmarking from South Korea within the setting of social enterprises and their comparison to actual external factors in Indonesia. The descriptive analysis from the comparative study of external factors and business models was carried out using PESTLE analysis tools (Politics, Economics, Social, Technology, Legal, Environment) and business model typology (Alter 2017). The results generates two business model recommendation, those are Independent Social Movement Business Model of Social Enterprises and Integrated – External Mixed Business Model of Social Enterprise.
Keyword: External factor, Industry 5.0, Business model, Social enterprise, Systematic literature review

Judul: Characterization Of Psen2 Gene Of Amyloid Disorder Of Alzheimer's Disease In Macaca Fascicularis
Abstrak: Presenilin2 (PSEN2) genes are the primary component of γ-secretase, responsible for the amyloid precursor protein sequence of proteolytic cleavage and the subsequent formation of amyloid β peptides. 18 RNA samples from the brain cortex and hippocampal regions of an adult group (10-12 years old); 4 female) and an old group (>15 years old; 5 females) of Cynomolgus monkey (Macaca fascicularis) were analyzed using RT-qPCR. There were no differences in PSEN2 mRNA expression in the cortex in between groups (p=0.063). There were significant differences in mRNA expression in the hippocampus in between groups (p= 0.010). The overall PSEN2 expression level was higher in the adult monkey group and correlated early onset Alzheimer’s disease (EOAD) characteristics in relatively young individuals. The overall PSEN2 expression level was low in the old monkey group. High PSEN2 expression in an adult group might correlate with the regulation of neuronal plasticity, amyloid precursor protein processing, and tau aggregation. It was increased in PSEN2 expression correlated with learning and memory impairment in the cortex and hippocampus. Alteration in PSEN2 expression may be a risk factor for Alzheimer’s disease. This study proposes that PSEN2 informational mutations could be included as useful gene biomarkers for the comprehensive prognosis of Alzheimer's disease in the Omnibus Gene Expression (GEO) database.
Keyword: cortex, Cynomolgus monkey, EOAD, hippocampus, PSEN2, RT-qPCR