Judul: Perbedaan Dampak Perubahan Iklim Berbasis Gender di Pulau Lombok, Nusa Tenggara Barat
Abstrak: Perbedaan dampak perubahan iklim dipengaruhi oleh tingkat kerentanan setiap individu termasuk dalam aspek gender. Perbedaan akses dan kontrol seringkali menjadikan perempuan lebih rentan terhadap perubahan iklim dibandingkan laki-laki sehingga dampak dan kapasitas adaptasi terhadap perubahan iklim akan berbeda. Tujuan dari penelitian ini adalah untuk memahami perbedaan dampak perubahan iklim dalam sudut pandang gender di Lombok, Nusa Tenggara Barat. Metode yang digunakan yaitu dengan melakukan pendekatan kuantitatif dan deskriptif dengan data dan informasi yang diperoleh dari tinjauan pustaka, survei lapangan, dan wawancara. Selain itu, dilakukan pula analisis kerentanan untuk wilayah Lombok menggunakan penilaian Livelihood Vulnerability Index (LVI). Hasil analisis tren perubahan iklim menunjukkan bahwa Lombok mengalami perubahan iklim, seperti peningkatan suhu udara dan peningkatan curah hujan selama 30 tahun terakhir. Kerentanan Lombok terhadap perubahan iklim berada pada rentang nilai LVI 0,395 sampai 0,474. Dampak perubahan iklim yang dirasakan antara laki-laki dan perempuan di Lombok berbeda tetapi tidak berbeda signifikan pada beberapa sub-indikator disetiap indikator akses, partisipasi, kontrol, dan manfaat (APKM). Hasil menunjukkan bahwa baik perempuan maupun laki-laki, tingkat kesiapan menghadapi dampak perubahan iklim masih rendah. Hal ini dapat dipengaruhi oleh berbagai faktor seperti, pendidikan, ekonomi, budaya, dan kebijakan pemerintah setempat., Differences in the impact of climate change are influenced by the level of vulnerability of each individual, including in terms of gender. Differences in access and control often make women more vulnerable to climate change than men, so the impact and adaptation to climate change will be different. This study aims to understand the differences in the impacts of climate change from a gender perspective in Lombok, West Nusa Tenggara. The method used is a quantitative and descriptive approach using data and information obtained from literature reviews, field surveys, and interviews. In addition, a vulnerability analysis was also carried out for the Lombok region using the Livelihood Vulnerability Index (LVI) assessment. The analysis of climate change trends shows that Lombok has experienced climate change, such as increasing air temperature and rainfall over the last 30 years. Lombok's vulnerability to climate change is in the LVI value range of 0.395 to 0.474. The impacts of climate change felt by men and women in Lombok are different but not significantly different in several sub-indicators in each indicator of access, participation, control, and benefits (APCB). The results show that for both women and men, the readiness to face climate change's impacts is still low. This can be influenced by various factors such as education, economy, culture, and local government policies.
Keyword: Access Participation Control Benefits (APCB), the impact of climate  change, vulnerability, gender mainstreaming, the strategy of adaptation

Judul: Analysis the Level of Vulnerability of Fishermen Households in Response to Climate Change: Case of Pari Island, South Seribu Islands, DKI Jakarta.
Abstrak: Perubahan iklim mengakibatkan terjadinya peningkatan intensitas dan frekuensi cuaca ekstrim, perubahan pola hujan, pengingkatan suhu air laut, dan terjadinya kekacauan musim angin. Dampak tersebut kemudian berpengaruh terhadap tingkat kerentanan rumah tangga nelayan. Penelitian ini menggunakan pendekatan kualitatif dan kuantitatif. Pendekatan kualitatif dilakukan dengan observasi dan wawancara mendalam kepada 4 orang informan sedangkan pendekatan kuantitatif dilakukan dengan menggunakan kuesioner kepada 50 responden dengan teknik snowball. Teknik pengolahan dan analisis data dilakukan menggunakan microsoft excel 2019 dan rumus perhitungan LVI-IPCC. Hasil penelitian menunjukkan bahwa nilai keterpaparan pada RT01 sebesar 0,49 dan RT04 sebesar 0,57. Selanjutnya, nilai kapasitas adaptif RT01 sebesar 0,59 dan RT04 sebesar 0,55. Sementara itu, nilai sensitivitas pada RT01 sebesar 0,40 dan RT04 sebesar 0,42. Nilai komponen tersebut kemudian menghasilkan nilai indeks kerentanan rumah tangga nelayan dimana indeks kerentanan RT04 lebih tinggi dibandingkan RT01 dengan nilai -0,04 pada RT01 dan 0,09 pada RT04. Kata kunci: kerentanan, perubahan iklim, rumah tangga nelayan, Climate change has resulted in an increase in the intensity and frequency of extreme weather, changes in rainfall patterns, increased sea temperatures, and chaotic wind seasons. These impacts then affect the level of vulnerability of fishing households. This research uses qualitative and quantitative approaches. The qualitative approach was conducted through observation and in-depth interviews with 4 informants, while the quantitative approach was conducted using a questionnaire to 50 respondents using the snowball technique. Data processing and analysis techniques were carried out using Microsoft Excel 2019 and the LVI-IPCC calculation formula. The results showed that the exposure value at RT01 was 0.49 and RT04 was 0.57. Furthermore, the adaptive capacity value of RT01 was 0.59 and RT04 was 0.55. Meanwhile, the sensitivity value at RT01 was 0.40 and RT04 was 0.42. The component values then produced the value of the vulnerability index of fishing households where the vulnerability index of RT04 was higher than RT01 with a value of -0.04 in RT01 and 0.09 in RT04. Keywords: climate change, fisher households, vulnerability
Keyword: climate change, Livelihood Vulnerability Index (LVI), fisher household

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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