Judul: Aktivitas Antioksidan dan Penghambatan α-Glukosidase Ekstrak dan Nanopartikel Ekstrak Kulit Kayu Mahoni (Swietenia macrophylla King)
Abstrak: Mahogany (Swietenia macrophylla King) bark is waste disposal industry manufacture of bark. Mahogany bark have catechin, epicatechin, and swietemacrophyllanin contents which useful as an antioxidants and antidiabetic of rats induced alloxan. This study aimed to determine the antioxidant activity and inhibition of α-glucosidase in the extract and nanoparticle extract of mahogany bark. Extraction method use aquades as solution, antioxidant activity assays was caried using 2,2-diphenyl-1-picrilhidrazyl (DPPH) and reducing power. Inhbition of α-glucosidase was measured with a spectrophotometric method. Mahogany moisture content was 4.87%. Extract yield of 9.46% and yield of nanoparticle 51.11% were obtained. The DPPH resulted that of the rutin compound, extract, and nanoparticles obtained by IC50 DPPH method sequentially 17.33 ± 1.17 ppm, 9.62 ± 0.72 ppm, and more than 2500 ppm. Respectively, power reduction of the rutin compound has a 67.03% at 25 ppm, the extract 67.41% at 20 ppm, and nanoparticle 31.47% at 20 ppm. IC50 values inhibition of α-glucosidase extract was 17.25 ppm, nanoparticles were more than 200 ppm, and acarbose was 0.37 ppm. The test results showed that the extract capable of acting as antioxidant and antidiabetic based on IC50 values. As for nanoparticles mahogany bark extract did not able to act as antioxidants and antidiabetics based on the method tested.
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Judul: Potensi Antihiperglikemia Ekstrak Kulit Kayu Mahoni (Swietenia macrophylla King) pada Tikus yang Diinduksi Aloksan
Abstrak: Mahogany bark (Swietenia macrophylla King) contain active compound which have antihyperglycemic activity. This research was aimed at investigating the effect of mahogany bark on blood glucose concentration and histopathology in rat’s pancreas which induced alloxan. On this research Sprague-Dawley rats were divided into 5 groups, each group were 5 rats, A (NaCl 0.9% + aquades), B (aloxan + aquades), C (aloxan + Glibenclamide 0.25 mg/kg BW), D (aloxan + water extract of mahogany bark 250 mg/kg BW), and E (aloxan + metanol extract of mahogany bark 250 mg/kg BW). Blood glucose concentration defined by using Accu-Chek® Active glucometer. Pancreas histopathology analysis was carried out with Haematoxylin Eosin (HE) staining and observed under light microscope. Result showed water extract of mahogany bark can decrease blood glucose concentration from 173,2 mg/dL to 94 mg/dL (45,73%) and methanol extract of mahogany bark can decrease blood glucose concentration from 118,6 mg/dL to 88 mg/dL (25,80%). Result of histopathology showed there was improvement on pancreas gland. Methanol extract given better restoration effect on the islets of Langerhans than water extract
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Judul: Sistem Pakar Perencanaan Jalur Saluran Transmisi dan Dimensi Pondasi Strap Footing Untuk Tower Listrik Saluran Udara Tegangan Tinggi (SUTT)
Abstrak: Pusat-pusat pembangkit tenaga listrik terutama yang menggunakan tenaga air, biasanya terletak jauh dari pusat-pusat beban. Dengan demikian, tenaga listrik yang telah dibangkitkan harus disalurkan melalui saluran-saluran transmisi. Saluran-saluran ini membawa tenaga listrik dari pusat pembangkit ke pusat-pusat beban baik langsung maupun melalui gardu-gardu induk. Pada penelitian ini, saluran transmisi yang diteliti adalah Saluran Udara Tegangan Tinggi (SUTT) berdaya 150 Kv. Secara ideal jalur saluran transmisi untuk SUTT yang terdiri dari beberapa tower adalah sebuah garis lurus. Akan tetapi dalam aplikasi lapangannya tidak demikian. Bisa saja berupa titik-titik dengan lokasi yang tidak beraturan, karena disesuaikan dengan kondisi lapangan. Setelah titik-titik rencana jalur saluran transmisi lokasi tower dapat dibuat, hal lain yang perlu didisain adalah dimensi pondasi tower tersebut. Apabila kita salah memilih atau merencanakan pondasi, maka kesalahan tersebut mengakibatkan terjadinya kerusakan pada struktur bangunan lainnya. Pondasi yang dipakai adalah pondasi telapak kombinasi (strap footing) dengan perbaikan tanah menggunakan pondasi sumuran (bore pile).
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