Judul: Aktivitas Koagulasi dan Antiinflamasi Hidrogel Cangkang Telur Ayam dan Ekstrak Etanol Jamur Kancing sebagai Penyembuh Luka Diabetes In Vitro
Abstrak: Gangguan pada proses koagulasi darah dan inflamasi kronis pada luka diabetes menyebabkan terhambatnya proses penyembuhan luka. Cangkang telur ayam dan jamur kancing diketahui berperan dalam proses penyembuhan luka karena komponen yang terkandung di dalamnya. Penelitian ini bertujuan menentukan formula serta menguji aktivitas koagulasi dan antiinflamasi hidrogel cangkang telur ayam dan ekstrak etanol jamur kancing sebagai penyembuhan luka diabetes secara in vitro. Metode penelitian diawali dengan proses ekstraksi menggunakan teknik maserasi, uji aktivitas koagulasi menggunakan darah kelinci yang diberi glukosa hingga mendekati kadar glukosa darah pada penderita diabetes, dan uji aktivitas antiinflamasi. Hidrogel dibuat sebanyak tiga formula dengan konsentrasi ekstrak etanol jamur kancing sebesar 6,4% dan konsentrasi cangkang telur 5% (F1), 10% (F2), dan 20% (F3). Seluruh formula hidrogel dapat mempercepat pembekuan darah dengan rentang waktu pembekuan sebesar 8,52– 11,24 menit. Hasil uji antiinflamasi hidrogel memiliki rentang nilai inhibisi sebesar 81,40–96,70%. Simpulan penelitian ini yaitu hidrogel F2 merupakan sediaan hidrogel yang memiliki waktu pembekuan darah dan aktivitas antiinflamasi terbaik., Disturbances in the blood coagulation process and chronic inflammation in diabetic wounds lead to delays in the wound healing process. Chicken eggshell and button mushrooms are known to play a role in the wound healing process because of the components contained therein. This research aimed to determine the formula, coagulation, and anti-inflammatory activity of hydrogel chicken eggshell and ethanolic extract of button mushrooms as a diabetic wound healer in vitro. The research method begins with the extraction process using maceration techniques, coagulation activity test using rabbit blood that is given glucose close to blood glucose in diabetics, and anti-inflammatory activity test. Hydrogels were made with three formulas used a 6,4% concentration of button mushroom ethanol extract and eggshell concentrations of 5% (F1), 10% (F2), and 20% (F3). All hydrogel formulas can accelerate blood clotting with a clotting time range of 8,52–11,24 minutes. The hydrogel anti-inflammatory test results had an inhibition value range of 81,40– 96,70%. It was concluded that F2 was the best hydrogel formula with blood clotting time and anti-inflammatory activity.
Keyword: anti-inflammatory, coagulation, button mushroom, diabetic wound, egg shell

Judul: Test the Effectiveness of the Combination Gel of Turmeric Nanoparticles and Sea Cucumber: Histopathological Study of Skin Incision Wound Healing
Abstrak: Luka adalah terputusnya kontinuitas jaringan kulit. Luka akan menimbulkan rasa tidak nyaman pada penderitanya. Penelitian ini adalah bagian dari uji pendahuluan untuk mengevaluasi aplikasi kombinasi gel nanopartikel ekstrak kunyit dan jeli gamat untuk proses penyembuhan luka sayat pada tikus Sprague-Dawley berdasarkan pengamatan mikroskopis. Kulit 10 ekor tikus jantan disayat pada bagian punggung. Perlakuan dibagi menjadi lima kelompok yaitu, kontrol negatif (P0), gel kombinasi 0,5% (P1), 1%(P2), 2% (P3), dan kontrol positif (P4). Pengobatan dilakukan setiap hari selama seminggu. Secara histopatologi, spesimen diwarnai dengan Hematoksilin-Eosin untuk mengamati struktur kulit dan AE1/AE3 untuk melihat ekspresi sitokeratin. Pengamatan dievaluasi pada hari ke-2 dan ke-7 pasca perlukaan. Parameter histopatologi yang diamati adalah keropeng, epitelisasi, dan neovaskularisasi. Data disajikan secara deskriptif melalui foto. Hasil pengobatan luka gel kombinasi hari ke-2 dan ke-7 menunjukkan luka mengalami penyembuhan. Penyembuhan pada luka yang diobati dengan gel kombinasi konsentrasi 0,5% paling baik dibandingkan pengobatan konsentrasi lainnya., Wound is a break in the continuity of skin tissue. The wound will cause discomfort in the sufferer. This study is part of a preliminary test to evaluate the application of a combination of turmeric extract nanoparticle and jelly gamat for the wound healing process in Sprague-Dawley rats based on microscopic observations. The skins of 10 male rats were cut 3 cm left lateral area. The treatments were divided into five groups namely, negative control (P0), 0,5% gel combination (P1), 1% (P2), 2% (P3), and positive control (P4). Treatment was given everyday in a week. Histopathologically, the specimens were stained with Hematoxylin-Eosin to observe the skin structure and AE1 / AE3 to observe cytokeratin expression. The observations were evaluated on the second and seventh days post-injury. The histopathological parameters observed were scab, epithelial formation, and neovascularization. Data were presented descriptively through light microscope. The results of wound treatment on second and seventh day showed that the wound had a healing process. Healing of wounds treated with a 0.5% combination gel is the best among other consentration of treatment.
Keyword: jelly gamat, microscopic, turmeric, wound healing

Judul: Asymptotic Distribution of Estimator for the Intensity Function of a Doubly Periodic Poisson Process
Abstrak: In this manuscript, estimation of the intensity function of a doubly periodic Poisson process is discussed. It is assumed that only a single realization of the Poisson process is observed in a bounded window [0,n]. It is also assumed that the period of the intensity function is known. The rate of consistency and asymptotic normality of the estimator are formulated. Finally, a confidence interval for the local intensity function is also formulated.
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