Judul: Potential of Active Compounds in Broadleaf Mahogany Seeds (Swietenia macrophylla) against Breast Cancer Cells using In Silico Analysis
Abstrak: Kanker payudara merupakan penyebab kematian terbesar akibat kanker di Indonesia. Namun, obat yang biasa digunakan memiliki efek samping dan menjadi resistan selama pengobatan. Ekstrak biji mahoni berdaun lebar (Swietenia macrophylla) telah teruji secara in vitro memiliki aktivitas sitotoksik pada sel kanker payudara MCF-7. Penelitian ini bertujuan memprediksi senyawa aktif dalam biji tumbuhan tersebut yang berpotensi sebagai antikanker payudara secara in silico. Senyawa aktif diprediksi dengan metode penambatan molekul, visualisasi hasil penambatan, dan analisis fisikokimia. Hasil penambatan menunjukkan 12 senyawa aktif diprediksi sebagai antikanker payudara. Visualisasi hasil penambatan menunjukkan terdapat tiga senyawa yang memiliki kesamaan mekanisme penghambatan dengan obat pembanding. Senyawa-senyawa tersebut ialah 3β,6- dihidroksidihidrokarapin, stigmasterol, dan 7-hidroksi-2-(4-hidroksi-3-metoksifenil)-kroman-4-on yang diprediksi dapat dikonsumsi secara oral.
Keyword: breast cancer, in silico, limonoid, mahogany seed, oral drug

Judul: Potential Compounds in Small Leaf Mahogany Seeds  (Swietenia mahogany) as Breast Anticancer with Molecular Docking Method
Abstrak: Di Indonesia, kanker payudara menempati peringkat pertama kasus kanker dengan penderita wanita terbanyak. Tamoxifen, Onapriston, dan Lapatinib, merupakan obat komersial antikanker payudara yang menimbulkan efek samping jika dikonsumsi dalam jangka panjang. Obat baru dari senyawa potensial bahan alam diperlukan sebagai alternatif, dapat dikembangkan secara komputasi dengan metode penambatan molekuler. Biji mahoni berdaun kecil (Swietenia mahagoni) dilaporkan berpotensi sebagai obat antikanker tersebut. Penelitian ini bertujuan memprediksi senyawa dalam biji mahoni berdaun kecil dan potensinya sebagai antikanker payudara dengan metode penambatan molekuler. dst ..., In Indonesia, breast cancer ranks first in cancer cases with the most female sufferers. Tamoxifen, Onapriston, and Lapatinib are commercial anticancer drugs that cause side effects if taken in the long term. New drugs from potential natural compounds are needed as alternatives and can be developed computationally with molecular docking methods. Small leaf mahogany seeds (Swietenia mahogany) are reported to have potential as an anticancer drug. This study aims to predict the compounds in small leaf mahogany seeds and their potential as anticancer breasts by molecular docking method. A total of 100 test ligands were docked to the estrogen receptor alpha (ERα), progesterone receptor (PR), and epidermal growth factor receptor (EGFR). Based on the results of molecular docking and the value of binding site similarity, the compounds 3,5,7,3',4',5'-hexahydroxyflavanone, isocorydine, 7-deacytoxy-7-oxogedunine, and stigmasterol, have potential as PR inhibitors. The results of pharmacokinetic and toxicity analysis showed that stigmasterol has the potential to be used as an oral drug and is not toxic.
Keyword: breast cancer, molecular docking, oral drug, Swietenia mahogany

Judul: Approximation of the Median of Poisson Distribution Using the Relation of Poisson-Gamma Distribution
Abstrak: A major drawback of median is that median cannot usually be defined in closed form, even in the cases where their distribution functions are known. This study gives an approximation of the closed form for the median of the Poisson distribution by using the relation of Poisson-Gamma distribution. The approximation uses elementary techniques based on the monotonicity of certain sequences involving tail probabilities of the Poisson distribution and the Central Limit Theorem. Furthermore, a closed form expression for the mean absolute deviation 􀜧|􀜰􀰒 􀵆 􀜯􀝁􀝀􁈺􀜰􀰒􁈻| is also studied. The median is relevant because of the fact that it minimizes the mean absolute deviation of a Poisson random variable (􀜰􀰒􁈻 by considering median as central tendency.
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