Judul: Sustainable Business Model Development of Salam Rancage Bogor Using Triple Layered Business Model Canvas (TLBMC)
Abstrak: Konsep bisnis keberlanjutan menekankan pada tiga aspek yaitu ekonomi, lingkungan dan sosial. Pengembangan konsep ini telah diterapkan melalui model bisnis keberlanjutan yang telah diadopsi oleh berbagai organisasi. Penelitian ini bertujuan untuk menganalisis model bisnis Salam Rancage Bogor sebagai social enterprise dengan fokus pada kondisi model bisnis saat ini, faktor internal dan eksternal serta merumuskan model bisnis baru. Penelitian ini dilakukan di Salam Rancage pada periode Desember 2022-Februari 2023. Data primer dikumpulkan melalui observasi lapangan dan wawancara mendalam kepada manajemen Salam Rancage, pengrajin dan pelanggan. Data sekunder meliputi dokumen pendukung dan data dianalisis menggunakan teknik analisis deskriptif dengan memetakan 27 elemen Triple Layered Business Model Canvas, analisis VRIO, tinjauan masa depan industri dan analisis SWOT. Penelitian ini mengeksplorasi model bisnis berkelanjutan yang diterapkan dengan fokus pada aspek ekonomi, lingkungan, dan sosial di komunitas. Keunggulan kompetitif yang berkelanjutan terletak pada kemampuan peningkatan permodalan, sistem organisasi, sumber daya manusia, reputasi dan kapabilitas baik secara internal maupun eksternal, sedangkan analisis eksternal berfokus pada kepedulian terhadap gaya hidup yang lebih sehat, peluang ekspor yang tinggi dan kerjama dengan berbagai pemangku kepentingan yang mendukung bisnis keberlanjutan. Penelitian ini menawarkan ide perencanaan model bisnis yang lebih fokus pada perbaikan peningkatan lapisan ekonomi dengan memulai evaluasi keuangan, mendefinisikan ulang konsumen, melakukan inovasi pada beberapa proyek percontohan dan berkolaborasi dengan berbagai pemangku kepentingan., The sustainability business concept emphasizes 3 aspects of economic, environmental and social. The development of this concept has been implemented through sustainable business models that have been adopted by various organizations. This research aims to analyze the business model of the Salam Rancage Bogor as a social business by focus on the current condition of the business model, internal and external factors and formulating a new business model. This research was conducted at Salam Rancage in the period December 2022-February 2023. Primary data was collected using field observations and in-depth interviews with management Salam Rancage, artisans and a customer. Secondary data includes supporting documents and data was analyzed using descriptive analysis techniques by mapping 27 elements of the Triple Layered Business Model Canvas, VRIO analysis, foresight industry and SWOT analysis. This research explores sustainable business models implemented with a focus on economic, environmental and social aspects in society. Sustainable competitive advantage lies in the capacity to increase capital, organizational systems, human resources, reputation and capabilities both internally and externally. while external analysis focuses on concerns for healthier lifestyles, high export opportunities and various stakeholders who support sustainable business. This research offers business model planning ideas that focus more on improving the economic layer by starting financial evaluations, redefining consumers, innovating several pilot projects and collaborating with various stakeholders.
Keyword: Business Model, Salam Rancage, Social Enterprise, Sustainability, Triple Layered Business Model Canvas

Judul: Sustainable Canvas Business Model Development for the Bigland Bogor Hotel
Abstrak: Bisnis berkelanjutan merupakan bisnis yang mengintegrasikan tiga aspek yaitu ekonomi, sosial dan lingkungan. Keberlanjutan saat ini menjadi tujuan utama pada setiap industri, Penerapan praktik berkelanjutan pada indsutri perhotelan memberikan sebuah manfaat yaitu adanya efesiensi penghematan sumber daya. Upaya industri perhotelan untuk bersedia mendukung bisnis berkelanjutan adalah menerapkan konsep hotel hijau. Hotel Bigland Bogor merupakan perusahaan yang bergerak di bidang industri perhotelan sehingga penerapan konsep hotel hijau sebagai bentuk upaya menerapkan konsep bisnis berkelanjutan. Berdasarkan latar belakang tersebut, tujuan dari penelitian ini adalah (1) Mengidentifikasi model bisnis saat ini yang sedang dijalankan oleh Hotel Bigland Bogor, (2) Menganalisis faktor lingkungan internal dan lingkungan eksternal yang mempengaruhi model bisnis Hotel Bigland Bogor dan (3) Merancang BMCS Hotel Bigland Bogor untuk masa mendatang. Penelitian ini menggunakan metode analisis deskriptif, BMCS, Analisis Lingkungan (Analisis Pasar, Kekuatan Industri, Tren Kunci dan Kekuatan Ekonomi Makro), SWOT dan Diskusi. Penelitian ini melakukan wawancara di bulan November 2023, kepada pemilik,wakil pemilik dan manajer Hotel Bigland Bogor untuk menganalisis kondisi eksisting yang sedang dijalankan oleh Hotel Bigland Bogor. Hasil penelitian menunjukan bahwa pertama, hasil penelitian BMCS eksisting menunjukan Hotel Bigland Bogor belum menjalankan konsep sustainability secara keseluruhan dari aktivitas yang dijalankan saat ini. Kedua, hasil analisis SWOT mendapatkan sembilan strategi yang kemudian dilakukan Diskusi dengan ketiga narasumber pada penelitian. Hasil Diskusi menyatakan bahwa 3 narasumber sepakat untuk menerapkan sembilan strategi yaitu merubah visi dan misi kearah sustainable, melakukan efesiesnsi penggunaan energi, meningkatkan dan memberikan pelayanan serta fasilitas kearah sustainability, mendaftarkan sertifikasi ECO Label, memberikan trainee keberlanjutan kepada karyawan, bekerja sama dengan vendor pengolahan limbah plastik, melakukan inovasi promosi hotel hijau dan mengganti botol plastik menjadi botol kaca. Sembilan strategi tersebut menjadi acuan perancangan BMCS baru Hotel Bigland Bogor, Terdapat perubahan dan penambahan pada 10 elemen BMCS, yaitu perubahan pada elemen vision and mission serta elemen competitor. Penambahan pada Key Partnership, Key Activities, Key Resources, Value Proposition, Customrer dan Cost Structure., Sustainable business is a business that integrates three aspects, namely economic, social and environmental. Sustainability is currently the main goal in every industry. The application of sustainable practices in the hotel industry provides benefits, namely the efficiency of saving resources. The hotel industry's effort to be willing to support sustainable business is to implement the green hotel concept. Hotel Bigland Bogor is a company operating in the hotel industry so the application of the green hotel concept is a form of effort to implement a sustainable business concept. Based on this background, the objectives of this research are (1) Identifying the current business model being run by the Bigland Bogor Hotel, (2) Analyzing the internal and external environmental factors that influence the Bigland Hotel Bogor business model and (3) Designing the BMCS of the Bigland Hotel Bogor for the future. This research uses descriptive analysis methods, BMCS, Environmental Analysis (Market Analysis, Industrial Strength, Key Trends and Macroeconomic Strengths), SWOT and discussion. This research conducted interviews in November 2023, with the owner, deputy owner and manager of the Bigland Bogor Hotel to analyze the existing BMCS currently being run by the Bigland Bogor Hotel. The research results show that first, the results
Keyword: BMCS, Environmental Analysis, Green Hotel, Discussion, SWOT

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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