Judul: Kajian Morfologi Penggunaan Bahan Biomaterial Hidroksiapatit: β-Trikalsium Fosfat pada Kerusakan Segmental Tulang Kelinci
Abstrak: This study was conducted to examine the healing process of rabbit’s bone implanted with mixture of hydroxyapatite-tricalcium phosphate (HA:β-TCP) with mixture ratio of 70:30 and 60:40. Six New Zealand white rabbits were used in this study. Hydroxyapatite β-tricalcium phospate implanted in the medial part of the right tibia using surgical procedures, while the same part of the left tibia served as controls without implants. The samples of tibia were taken on 30 days after implantation. Parameters observed were the shape, the degradation rate of the implant, the implant bonds with the bone, new bone growth into the implant, and the signs of inflammatory reaction around the implant. The results of this study showed that the healing process in control samples was faster than bone treated with implant. There was no macroscopically morphological difference observed between the bones implanted with mixture of 70:30 and those with 60:40. But, there was difference observed microscopically. Osteocytes was observed in the bones implanted with mixture of 60:40 and there was no osteocytes observed in the bones implanted with mixture of 70:30. At day 30, the implant of HA:β-TCP showed potency of biodegradability, bioresorbability, osteoconductivity, and good biocompatibility for body. It is suggested that the next research of this mixture as bone implant is still needed to find the optimal composition
Keyword: Bogor Agricultural University (IPB), rabbit bone, hydroxyapatite, healing process, bone implants, beta-tricalcium phosphate

Judul: Kajian Morfologi Proses Persembuhan Kerusakan Segmental Pada Tulang Domba Yang Diimplan Dengan Komposit Hidroksiapatit-Trikalsium Fosfat (HA-TKF)
Abstrak: This study was aimed to evaluate in vivo osteogenesis potency of bones implanted with graft of hydroxyapatite-tricalcium phosphate (HA-TCP) composite. This study also observed the potential use of HA-TCP as bone substitution material. Three local sheeps were used in this study. The implant was inserted under aseptic surgery on the proximal medial of the left tibia bone and as control the proximal medial of the right tibia bone was drilled without implant. Bones were harvested after 30, 60, and 90 days post-surgery and observed macroscopic and microscopically. The parameters of observation were the condition, shape and degradation degree of the implant, bonding between implant and host bone, new bone growth into the implant and signs of inflammation reaction around the implant. The result showed that the healing process on control bone was faster than those of the implanted bone. The bone implant had been already degradated in treated group of day 30 post-surgery. HA-TCP bone implant shown some signs for its biocompatibility, biodegradability, bioresorbability and osteoconductivity properties. Therefore, it is suggested that HA-TCP implant might be used as bone substitution in the bone lesions with approximately 30 days of recovery.
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Judul: Pengaruh ENSO terhadap Variabilitas Ozon Total di Indonesia
Abstrak: Konsentrasi ozon total di atmosfer adalah jumlah ozon total yang ada di lapisan stratosfer dan troposfer yang lebih banyak merepresentasikan ozon stratosferik karena jumlahnya yang lebih banyak dibandingkan ozon troposferik. Ozon adalah salah satu gas aktif yang memiliki dampak besar terhadap keseimbangan radiasi dan iklim global. Penelitian ini bertujuan mengetahui variabilitas parameter suhu dan ketinggian geopotensial yang berkaitan dengan ozon total dan mengidentifikasi pengaruh fenomena ENSO terhadap jumlah ozon total di Indonesia. Data yang digunakan adalah data total kolom ozon, suhu, dan ketinggian geopotensial bulanan dari ERA5 dan indeks Nino 3.4 bulanan dari NOAA tahun 1996-2016. Hasil yang diperoleh dari analisis komposit adalah parameter suhu 100 mb dan ketinggian geopotensial 100 mb di lapisan stratosfer bawah pada saat El Nino mengalami anomali negatif, begitu pula dengan ozon, sedangkan pada saat La Nina menunjukkan pola yang terbalik, khususnya di Bulan Desember, Januari, dan Februari. Hasil analisis korelasi antara ozon total dengan indeks Nino 3.4 menunjukkan hasil koefisien korelasi pada musim kering (Mei-Oktober) berkisar -0.95 ≤ r ≤ 0.35 dan pada musim basah (November-April) berkisar -0.93 ≤ r ≤ 0.64 dengan sebagian besar korelasi bernilai negatif di seluruh wilayah Indonesia. Hasil tersebut menunjukkan bahwa adanya anomali positif dari suhu permukaan laut di wilayah Pasifik Timur (El Nino) akan menyebabkan penurunan ozon total, begitu pula sebaliknya., Total column ozone is the total amount of ozone in the stratosphere and troposphere layer, which represent more stratospheric ozone considering that it is more abundant than tropospheric ozone. Ozone is one of the active gases that has a major impact on the radiative forcing and the global climate. This study aims to determine the temperature and geopotential height parameters variability related to total ozone and to identify the effect of ENSO on the total amount of ozone in Indonesia. The data used are total column ozone, temperature, and geopotential height monthly data from ERA5 and monthly Nino 3.4 index from NOAA in 1996-2016. Using composite analysis, it found that temperature and geopotential height parameters in the lower stratosphere during El Nino will experience negative anomalies in line with negative anomalies ozone, while during La Nina shows an opposite pattern, especially in December, January, and February. The results of correlation analysis between total column ozone and Nino 3.4 index showed a significantly negative correlation coefficient almost all over Indonesia, with ranges -0.95 ≤ r ≤ 0.35 in the dry season, and -0.93 ≤ r ≤ 0.64 in the wet season. It indicates that the presence of a positive anomaly of sea surface temperature in the East Pacific region (El Nino) will cause a decrease in total ozone and vice versa.
Keyword: ERA5, ketinggian geopotensial, suhu, ozon total