Judul: Aktivitas hepatoproteksi Ekstrak Polifenol Buah Delima (Punica granatum L.) Terhadap Tikus Putih yang Diinduksi Parasetamol
Abstrak: The patient of liver disease more increase. Pomegranate has been higher antioxidant activities and reported as hepatoprotection. The research to make for activity pomegranate polifenol as hepatoprotector and influence in liver histopathology of rat to induction by paracetamol. Polyphenol extracted by mixture solvent acetone:water:acetid acid (90:9.5:0.5). There are 22 rats randomly divided into 7 following group, they are group I allowed fed with strandard pellet, group II allowed fed with strandard pellet and paracetamol 500 mg/kg BB, group III allowed fed with strandard pellet, paracetamol 500 mg.kg BB, and cursil-70 13.3 mg/kg BB, group IV, V, VI, and VII allowed fed with strandard pellet, paracetamol 500 mg/kg BB, and extract polyphenol of pomegranate with doses 13.3 mg/kg BB, 100 mg/kg BB, 250 mg/kg BB, and 500 mg/kg BB for severally group. Experiment was conducted for 34 days and at the last day, observed liver histopathology about number of necrotic cells, apoptosis cells, kupfer cells, and fatty degeneration. Polyphenol extract of pomegranate with dose 500 mg/kg BB to point out possible chase destruction of liver (p<0.05) because number of necrotic cells is low, nothing apoptosis cells, number of kupfer cells is low, and fatty degeneration is low
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Judul: Uji aktivitas hepatoprotektor ekstrak air pegagan (Centella asiatica) terhadap tikus putih jantan yang diinduksi parasetamol
Abstrak: This study was undertaken to investigate activity of Centella asiatica extract against paracetamol induced liver damage in male Wistar albino rats. Rats were divided into five groups namely control (aquadest), herb extract with four formulations which were F 6, F 10, F 12, and F 16. Rats were administered paracetamol at dose 1000 mg/kg bw (p.o) as toxic dose for inducing hepatotoxicity. Herb extract in each formula was given at dose 1500 mg/kg bw (p.o) one hour after paracetamol administration. The treatment was given for eight days and blood was collected three times (before treatment, after paracetamol treatment, and last treatment) from tail artery and analysed for serum glutamate pyruvate transminase (SGPT). The hepatoxicity produced by acute paracetamol administration was found to be inhibited by Centella asiatica at group F 16 with evidence of decreased level of serum glutamate pyruvate transminase (SGPT) consentration. The hepatoprotective activity Centella asiatica was also supported by histopathological studies of hepatocytes
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Judul: Metrik Einstein (Anti-) Self-Dual Berdimensi Empat dengan Metode Cartan
Abstrak: Gravitational field equation can be formulated in differential forms (differential geometry), which describes gravity as a manifestation of the curvature of space-time. Curvature of space-time is characterized by a metric that satisfies the gravitational field equation. With differential forms it can be formulated the (anti-) self-dual Einstein equation, which is a modification of the Cartan structure in (anti-) self-dual basis. Calculation of (anti-) self-dual metric with (anti-) self-dual Einstein equation is simpler than the calculation using Christoffel symbols.
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