Judul: Potensi Antihiperglikemia Ekstrak Kulit Kayu Mahoni (Swietenia macrophylla King) pada Tikus yang Diinduksi Aloksan
Abstrak: Mahogany bark (Swietenia macrophylla King) contain active compound which have antihyperglycemic activity. This research was aimed at investigating the effect of mahogany bark on blood glucose concentration and histopathology in rat’s pancreas which induced alloxan. On this research Sprague-Dawley rats were divided into 5 groups, each group were 5 rats, A (NaCl 0.9% + aquades), B (aloxan + aquades), C (aloxan + Glibenclamide 0.25 mg/kg BW), D (aloxan + water extract of mahogany bark 250 mg/kg BW), and E (aloxan + metanol extract of mahogany bark 250 mg/kg BW). Blood glucose concentration defined by using Accu-Chek® Active glucometer. Pancreas histopathology analysis was carried out with Haematoxylin Eosin (HE) staining and observed under light microscope. Result showed water extract of mahogany bark can decrease blood glucose concentration from 173,2 mg/dL to 94 mg/dL (45,73%) and methanol extract of mahogany bark can decrease blood glucose concentration from 118,6 mg/dL to 88 mg/dL (25,80%). Result of histopathology showed there was improvement on pancreas gland. Methanol extract given better restoration effect on the islets of Langerhans than water extract
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Judul: Khasiat antioksidasi ekstrak kulit kayu mahoni (Swietenia macrophylla King) terhadap peroksidasi lipid pada hati tikus hiperurisemia
Abstrak: The bark of mahogany (Swietenia macrophylla King) contains bioactive compounds, which has been reported as an antioxidant. But there had been very few in vivo evidence of the antioxidant effectiveness on the liver lipid peroxidation in hyperuricemic rats. This study aimed to test the effect of mahogany (Swietenia macrophylla King) bark extracts against lipid peroxidation in hyperuricemic rat liver. Thirty three rats were divided into 5 groups, namely normal, hyperuricemic (HU), allopurinol (HU I), aqueous extract (HU II) and methanol extract (HU III). Hyperuricemic induction was carried out by giving the juices of chicken liver and sodium carboxyl methyl cellulose 0.5%. The induction was administered orally for 4 weeks with dosage of 25 g/kg BW. Afterwards, rat were administered by aqueous extract and methanol extract at 500 mg/Kg BW day for 7 days. Liver lipid peroxides analysis was determined by using thiobarbituric acid (TBA) method. The results showed that the lipid peroxide concentrations of hyperuriemic, allopurinol and methanol extracts group were 101.51 ± 54.74 nmol/gram, 108.55 ± 45, nmol/g and 101.04 ± 26.68 nmol/gram, respectively. The aqueous extract has the antioxidants effect on rat liver lipid peroxidation with the concentration of 63.57 ± 16.84 nmol/g, smaller than that of the normal group (93.83 ± 29.55 nmol/gram). Statistically, the aqueous extract tend to decrease the liver lipid peroxide concentration of hiperuricemic rat by 32.25% (p = 0.054).
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Judul: Dinamika dan Faktor yang Memengaruhi Permintaan Tenaga Kerja Sektor Konstruksi di Indonesia
Abstrak: Ketersediaan infrastruktur merupakan landasan bagi pembangunan suatu negara. Salah satu sektor yang sangat berperan bagi pembangunan infrastruktur adalah sektor konstruksi. Namun walaupun sektor tersebut cukup memberikan andil yang besar terhadap pembangunan infrastruktur, kondisi ketenagakerjaan pada sektor konstruksi memperlihatkan penurunan jumlah pada tahun 2016-2017. Sehingga tujuan dari penelitian ini yaitu untuk menganalisis dinamika tenaga kerja sektor konstruksi serta faktor-faktor yang memengaruhi permintaan tenaga kerja sektor konstruksi di Indonesia. Metode yang digunakan dalam penelitian ini adalah model panel data. Analisa deskriptif dan kuantitatif digunakan untuk menganalisis dinamika tenaga kerja dan faktor-faktor yang memengaruhi permintaan tenaga kerja sektor konstruksi di Indonesia. Hasil penelitian ini menunjukkan bahwa seluruh variabel independen berpengaruh signifikan terhadap variabel dependen. Variabel PDRB sektor konstruksi berpengaruh positif terhadap permintaan tenaga kerja sektor konstruksi. Sedangkan variabel pengeluaran infrastruktur, pertumbuhan PDRB, dan upah sektoral riil berpengaruh negatif terhadap permintaan tenaga kerja sektor konstruksi di Indonesia.
Keyword: construction, infrastructure, labor dynamics