Judul: Gambaran histopatologi jaringan ateroma aorta potong beku dari kelinci New Zealand white (Oryctolagus curiculus) Hiperlipemik dengan dan tanpa antihiperlipidemia
Abstrak: The aim of the research is to investigate the histopathology of atheroma lesion within aorta wall from hyperlipemic rabbit (Oryctolagus cuniculus) with and without antihyperlipidemia drug treatment using Cryo-section method. The research use 12 New Zealand white rabbit (Oryctolagus cuniculuc;) devided into 3 groups, hyperlipemic rabbit group (H), hyperlipemic rabbit group with anti-hyperlipidemia drug treatment (HA) and control group (KN). The hyperlipemic condition of the animal was obtained by giving the rabbit 02g/day pure cholesterol for 3 months, and anti-hyperlipidemia drug of choice is statin dose 1.25glday for 2 month treatment. The examination of aorta wall revealed that the New Zealand white rabbit is responsive for the atherogenesis process, The atherogenesis observed inclllde lipid accumulation on the endothelial surface, lipid initiation in the intimal up to the medial layer of aorta wall and atheroma plaque formation. All the rabbits showed the athrogenesis process. The anti-hyperlipidemia drug could decrease the blood total cholesterol level and damaged the plaque structure. The cryo-section technique with Sudan Black staining could show lipid distribution on arterial wall and fragile atheroma lesion obviously.
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Judul: Proses Peroksidasi Lipid Kelinci yang Hiperlipidemia pada Pemberian Senyawa Penurun Kolesterol
Abstrak: Free radicals, such as lipid peroxide, are having much attention right now because their significant role in degenerative disease. Hyperlipidemia is one of the major risk factor for atherosclerosis and lead to degenerative disease. The aim of this study was to determine the effect of cholesterol lowering substance to the blood peroxide lipid concentration in hyperlipidemic rabbit. Twenty four male New Zealand white rabbits were divided into four groups: normal (given standard rabbit feed), hyperlipidemia (given atherogenic rabbit feed contained 0.5% cholesterol and 5% coconut oil), lovastatin (given mixture of atherogenic rabbit feed and lovastatin 57 mg/day), and extract (given atherogenic rabbit feed and jati belanda leaves extract mixture). Thiobarbitnric acid (TBA) method was used in blood lipid peroxide analysis, measuring the MDA product by spectrophotometer at 532 nm. The result showed that the atherogenic rabbit feed caused the elevation of MDA concentration, which means the elevation of lipid peroxidation process. Blood lipid peroxide concentration in hyperlipidemia group increased 163.76% compared with normal group (1.30 ± 0.38 nmol/ml). Lovastatin and jati belanda leaves extract mixture can act as antioxidant which can lowering blood lipid peroxide concentration 46.92% and 53.03% respectively at 8th week compared with hyperlipidemia group.
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Judul: Peranan Pemimpin Informal dalam Menggerakan Partisipasi Masyarakat  untuk Pembangunan Desa
Abstrak: Pendekatan pembangunan yang banyak diterima para ahli adalah pendekatan dari bawah ke atas (bottom up) yang berarti bahwa dalam pembangunan diperlukan keikutsertaan rakyat. Keikutsertaan tidak hanya pada tahap merencanakan pembangunan, akan tetapi juga ikut dalam melaksanakan, bahkan sampai pada menilai hasil-hasil pembangunan (Cohen dan Uphoe 1977; Dusseldorp, 1981; Slamet, 1993). Agar rakyat yang berhimpun dalam kelompok-kelompok dapat ikut serta, mereka harus memiliki sejumlah kualifikasi yang diperlukan untuk itu.
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