Judul: Aktivitas hepatoprotektor ekstrak metanol daun kari (Murraya koenigii .L.) pada tikus putih Sprague dawley, Activity of Curry Leaf (Muraya koenigii. L.) Methanol Extract as Hepatoprotector in Sprague dawley Rats
Abstrak: Curry leaf is being thought as hepatoprotector againts liver damage caused by hepatotoxic agent such as paracetamol. This study was assesing the activity of curry leaf extract in reducing the activity of ALT (alanine aminotransferase) and AST (aspartate aminotransferase) in rats were given high dose paracetamol. Total of 25 rats were used in this research which were divided into 5 experimental groups as follows: normal control group (N), negative control group (KN) (paracetamol dose 500 mg/Kg BW were given 21 days), positive control group (KP) (curliv dose 42.86 mg/Kg BW were given 21 days), dose 200 mg/Kg BW extract group (ED200), and dose 300 mg/Kg BW extract group (ED300). Extracts were given 7 days before paracetamol treatment and continous until end of experiment. Pytochemistry test results showed that curry leaf methanol extract contain alcaloids, tannins, saponins, and steroids. Extract group had not significantly reduced ALT and AST activity (p>0.05) compared to N group. Decreasing ALT and AST activity in ED200 group is 16.21% and 33.82%. Decreasing ALT and AST activity in ED300 group is 33.82% dan 62.60%. Methanol extract curry leaf had hepatoprotector activity although not significantly differences.
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Judul: Aktivitas ekstrak etanol-air daun kari (Murraya koenigii) sebagai hepatoprotektor pada tikus putih galur Sprague Dawley
Abstrak: Curry leaves (Murray koenigii), a traditional Indian medicinal plant is one of the herbal plants that has been reported to have high in vitro antioxidant activity. This study was designed to investigate phytochemical compound and hepatoprotective activity of ethanol:water (1:1) extract of curry leaves (EWEC) on paracetamol toxic dose induced acute liver damage in Sprague Dawley rats in vivo. Hepatoprotection activity was measured by using biochemical parameters such as enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) serum level and to observe the histopathology study of liver. Twenty five rats were divided into 5 groups: normal group (N), negative control group/KN (paracetamol 500 mg/Kg BB), positive control group/KP (Curliv-plus® 42,86 mg/Kg BB), EWEC groups doses 200 mg/Kg BB and 300 mg/Kg BB. Curry leave was extracted with a solvent mixture of ethanol:water (1:1) which resulted about 19,2% rendement. Phytochemical test indicates that EWEC contains alkaloids, saponins, steroids, and tannins. Transaminase enzyme serum analysis shows that the induction of EWEC 300 and KP treatment gives a significant effect (p<0.01) on hepatoprotective compared to EWEC 200. However, liver histopathology shows that there is a necrosis hepatocytes on KN group, regeneration on KP group, vacuolisation on EWEC 200, and normal cells on EWEC 300. These results indicate that the antioxidant of EWEC is potential to protect liver cells.
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Judul: Asymptotic Distribution of Estimator for the Intensity Function of a Doubly Periodic Poisson Process
Abstrak: In this manuscript, estimation of the intensity function of a doubly periodic Poisson process is discussed. It is assumed that only a single realization of the Poisson process is observed in a bounded window [0,n]. It is also assumed that the period of the intensity function is known. The rate of consistency and asymptotic normality of the estimator are formulated. Finally, a confidence interval for the local intensity function is also formulated.
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