Judul: Dampak Pengembangan Pariwisata dan Sikap Nelayan di Desa Pangandaran
Abstrak: Development of coastal tourism can give directly impact on the social and cultural life of fisherman communities and influence the attitudes of fishermen. This study intend to analyze the impact of tourism development on the social structure and cultural values as well as analyzing the attitudes of fishermen towards the tourism development. The research was conducted in Pangandaran village using survey methods. The results showed that the development of tourism impact on the social structure of fishermen namely the growth of social organization, social stratification, migration and composition of the population, as well as the livelihoods and incomes. Whereas the impact on the cultural value of fishermen include namely the waning tradition of local fishermen, fishermen lifestyle changes, and increased knowledge of fishermen. Fishermen status and income level have a real relationship with the attitude of fishermen, whereas age and education level did not have a real relationship with the attitude of fishermen
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Judul: Perubahan Sosial pada Masyarakat Pesisir (Kasus: Kawasan Wisata Pantai Pangandaran)
Abstrak: Every society will definitely experience social change. Social change is a change that occurs in human life which includes changes in behavior patterns, social values, social institutions, layers in society, power and authority, and social interactions. This research aims to analyze social changes in coastal communities and community attitudes towards social change in Pangandaran Village. The research was conducted in Pangandaran Village using a mix method approach. The qualitative approach was carried out using in-depth interviews with informants, while the quantitative approach used questionnaires for 60 respondents. The research results show that the source of social change in the Pangandaran Village community is caused by tourism development. The impact of tourism development can be seen from changes in social structure and levels of welfare. This research also shows that people's attitudes towards social change are dominated by positive attitudes. The characteristics of age have a significant correlation with attitudes towards social change. Meanwhile, the characteristics of gender, type of work, level of education, and level of income do not have a significant correlation with attitudes towards social change
Keyword: coastal communities, tourism, attitudes, social changes

Judul: Prediction of the Structure of the Glucose Oxidase Enzyme Mutant Aspergillus niger IPBCC.08.610 for Enzymatic Fuel Cell Aplication
Abstrak: Enzymatic fuel cell (EFC) merupakan perangkat energi terbarukan yang memanfaatkan reaksi enzimatis untuk menghasilkan energi listrik. Enzim digunakan karena memiliki sensitifitas kerja yang tinggi terhadap substratnya. Salah satu enzim yang digunakan dalam perangkat EFC adalah enzim glukosa oksidase (GOD). Enzim ini bekerja mengoksidasi β-D-glukosa menjadi D-glukono-δ-lakton dan hidrogen peroksida. Enzim glukosa oksidase yang digunakan dalam penelitian ini merupakan enzim glukosa oksidase dari Aspergillus niger IPBCC.08.610 (GOD_IPBCC_1CF3). Dalam pengaplikasiannya sebagai EFC, enzim GOD_IPBCC_1CF3 menemui beberapa permasalahan yang harus dihadapi, diantaranya adalah terkait nilai konstanta Michaelis-Menten (Km). Standar nilai Km enzim sebagai EFC adalah sebesar 11-41 μM, sedangkan enzim GOD_IPBCC_1CF3 memiliki nilai Km sebesar 2.9 μM. Untuk menangani permasalahan tersebut, penelitian ini dilakukan untuk meningkatkan nilai Km enzim GOD_IPBCC_1CF3 dengan melakukan prediksi mutasi pada struktur enzim. Tipe mutasi yang dilakukan adalah mutasi tunggal pada dua residu yaitu E412 dan H516. Prediksi mutasi dilakukan menggunakan struktur 3D enzim GOD_IPBCC_1CF3 hasil prediksi yang dilakukan pada penelitian sebelumnya. Berdasarkan hasil analisis molecular docking dan dinamika molekuler 38 struktur mutan enzim GOD_IPBCC_1CF3, diperoleh 11 struktur mutan terpilih dan selanjutnya dianalisis kestabilannya menggunakan simulasi dinamika molekuler untuk mendapatkan struktur mutan yang memiliki kemampuan meningkatkan nilai Km dan juga memiliki kestabilan struktur yang baik. Simulasi dinamika molekuler dalam penelitian ini dilakukan selama 50 ns dengan temperatur 300 K. Hasil analisis menggambarkan dari 11 struktur mutan yang dianalisis terdapat empat struktur mutan yang memiliki stabilitas struktur yang baik, yaitu mutan E412C, E412T, H516E dan H516W. Stabilitas ini dinilai berdasarkan data plot RMSD, RMSF, struktur sekunder dan jembatan garam. Serta hasil analisis energi bebas (free energy) menggunakan metode MMPBSA mengungkapkan dari 11 struktur mutan enzim GOD_IPBCC_1CF3 yang dianalisis terdapat 10 struktur mutan yang diprediksi dapat meningkatkan nilai Km, dan satu struktur sisanya tidak dapat meningkatkan nilai Km enzim GOD_IPBCC_1CF3., Enzymatic fuel cell (EFC) is a renewable energy device that utilizes enzymatic reactions to produce electrical energy. Enzymes are used because they have a high sensitivity to their substrates. One of the enzymes used in the EFC device is glucose oxidase (GOD). It oxidizes -D-glucose to D-glucono-δ-lactone and hydrogen peroxide. The glucose oxidase enzyme used in this study derived from Aspergillus niger IPBCC.08.610 (GOD_IPBCC_1CF3). In its application as an EFC, the enzyme GOD_IPBCC_1CF3 encountered various problems, including the value of the Michaelis-Menten constant (Km). The standard Km value for the glucose oxidase enzyme to be used as an EFC is to have a Km value of 11-41 M, while for the GOD_IPBCC_1CF3 enzyme it has a Km value of 2.9 M. To overcome this problem, research was carried out to increase the Km value of the GOD_IPBCC_1CF3 enzyme by changing the structure enzyme. The type of mutation carried out was a single mutation in two residues, namely E412 and H516. Mutation prediction was carried out using the 3D structure of the GOD_IPBCC_1CF3 enzyme as predicted in previous studies. Based on the molecular docking analysis and molecular dynamics simulation of 38 GOD_IPBCC_1CF3 mutant structures, 11 selected mutant structures were obtained and then analyzed using molecular dynamics simulations to obtain a mutant structure that can increase the Km value and also has good structural stability.
Keyword: Enzymatic fuel cell, Konstanta Michaelis-Menten, Simulasi dinamika molekuler, Glukosa oksidase, glucose oxidase, Enzymatic fuel cell, Michaelis-Menten constant, molecular dynamics simulation