Judul: Hematological and Histopathological Organs Studies on Quinine Induced Rat as Metabolic Potential Test of Angkak.
Abstrak: This research was purposed to analyze potency of angkak on hematological parameters and organs recovery in quinine induced rat. Rats were randomly divided into five groups. Group I were given orally aquades, group II received 100 g/kg bb quinine 14 day afterward not received angkak, group III received 100 g/kg bb quinine 14 day afterward received 0.04 g/kg bb angkak 14 day, group IV received 100 g/kg bb quinine afterward received 0.08 g/kg bb angkak, and group V not received quinine afterward received 0.04 g/kg bb angkak. Hematology analysis measured every 3 day. At 29 th day, the rats were necropsied to see the lesion on the liver and kidney both macroscopically and microscopically. The treatment with angkak can increasing the body weight of the rats (p<0.05). Analysis result of platelet showed that treatment using 0.04 g/kg bb angkak able to increase the sum of platelets (p<0.05). The treatment using angkak have not demonstrated significantly effect on red blood cell, hemoglobin, and hematocrit (p>005). Observation histopathology of the test animals liver and kidney showed the treatment using 0.04 g/kg bb and 0.08 g/kg bb angkak was confirmed helping the liver and kidney to recover from histopathology lesion caused negative effect. Statistical analysis result showed that recover using angkak is differently significant.
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Judul: Potensi Metabolik Buah Merah Terhadap Perbaikan Hematologi dan Organ Tikus yang Diinduksi Kuinin
Abstrak: The aim of this research is to find out the influence of the red fruit extract (RFE) in the blood picture, liver and kidney of mice which induced quinine. Twenty five mice were divided into 5 groups; the groups are No (normal), the group K (quinine), the S1 (quinine and SBM 0,9 ml / kg BB/day), S2 groups (quinine and SBM 1,8 ml/ kg BB/day) and the S3 (only RFE dosage of 0,9 ml/kg BB/day). The blood sampling were done in the 0, 3rd, 7th, 10th, 14th, 17th, 20th, 23rd and 29th day. Nekropsi was done after the RFE was stopped. Liver and kidney organs were retrieved and processed into histopathology preparate with Haematoxylin-Eosin (HE) coloring. Histopathology examination was done for each group, by 20 observation of field perspective and the result were counted to get the average. Profile of blood does not change. Giving red fruit extract can increase the number of thrombocyte although statistically it was not significant (P>0,05). The damage of liver which caused by quinine, for instance hidropis degeneration, edema, and nekrosa were retarded by RFE treatment with dosage 0,9 ml/ kg BB/ day. The damage in kidney which caused by quinine (hidropis degeneration on tubuli cells, edema glomerulus, and the expansion lumen tubuli) was also retarded by the treatment. Degeneration of hidropis and nekrosa can expand in kidney with 1,8 ml/kg BB/day RFE.
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Judul: Konstruksi Persamaan Friedmann Alam Semesta Friedmann-Lemaitre-Robertson-Walker Termodifikasi Materi Gelap Superfluida
Abstrak: Kosmologi merupakan salah satu objek kajian dari teori relativitas umum. Salah satu model dalam kosmologi adalah model kosmologi Friedmann. Model kosmologi Friedmann dibangun berdasarkan asumsi bahwa materi dan energi terdistribusi secara homogen dan isotropik di alam semesta. Teori relativitas umum dapat dimodifikasi melalui pendekatan teori materi gelap superfluida (MGS). Persamaan medan Einstein untuk teori MGS dapat dirumuskan melalui prinsip aksi dengan memodifikasi Lagrangian pada aksi teori MGS. Selanjutnya dengan memilih metrik Friedmann-Lemaitre-Robertson-Walker (FLRW) datar dengan indeks kurvatur sama dengan nol, dapat dibangun suatu bentuk persamaan Friedmann yang dimodifikasi teori MGS.
Keyword: kosmologi, teori materi gelap superfluida, persamaan medan Einstein, metrik FLRW, persamaan Friedmann.