Judul: Potensi Tepung Umbi Dioskorea (Dioscorea alata) untuk Mencegah Aterosklerosis pada Kelinci Percobaan
Abstrak: Recently, cardiovascular disease is one of the main causes of adult mortality in the world including in Indonesia. One of major risk factors of cardiovascular disease is hyperlipidemia. Prolonged hyperlipidemia accompanied by LDL oxidation is the first step of the development of atherosclerosis. Selection of food consumed is one way to reduce the risk of the development of atherosclerosis. Dioscorea alata (DA) tuber has potency to reduce the risk of atherosclerosis because it contains several functional compounds; anthocyanins, dietary fiber, and diosgenin. This contents lower the risk by antioxidation, antihyperlipidemia, and antiaggregation mechanisms. The objective of this research was to study the effect of administration of DA flour to inhibit atherosclerosis in laboratory rabbits. There were five specific objectives of the research ; (1) to determine the citric acid concentration and the duration of steam blanching which produce DA flour with the higest bioactive compounds, (2) to determine antioxidation and anti platelet aggregation effects of DA flour by in vitro test, (3) to examine the effects of DA flour administration on the activity of antioxidant enzymes in serum and kidney by in vivo test, 4) to examine the effect of DA flour administration on blood lipid profiles of the rabbits; and (5) to analyze the development of atherosclerosis plaques in aorta, and examine the morphologic change in rabbits kidney tissues. The results showed that 1% citric acid soaking and 10 minutes blanching produced DA flour with the highest anthocyanins and polyphenolic retention as high as 44.51% or 104.36 mg/100 g flour and 62.58% or 198.52 mg equivalent gallic acid/100 g flour, respectively. The flour had antioxidant capacity equal to 1300 mg trolox/100 g. Five or ten minutes steam blanching could reduce the activity of polyphenol oxidase enzyme, therefore retarded the oxidation process that degraded polyphenolic compound. These treatments were applied to produce DA flour which later formulated into rabbits ration. DA water extracts and flours were co-administrated with high cholesterol ration to 30 male New Zealand White rabbits for 60 days with the following ration groups; 1) basal ration as negative control (K0); 2) basal ration with 0.5% cholesterol as positive control (K1); 3) basal ration with 0.5% cholesterol and 1.8 g/100 g of freeze dried DA extract (KE1); 4) basal ration with 0.5% cholesterol and 3.6 g/100 g of freeze dried DA extract (KE2); 5) 15% DA flour in basal ration with 0.5% cholesterol (KT1); and 6) 30% DA flour in basal ration with 0.5% cholesterol (KT2). Experiment on antioxidatif stress effect of DA flour in rabbits showed that the level of SOD serum in rabbit co-administrated with DA flour to high cholesterol ration was significantly higher compared to those fed with cholesterol ration. 30% DA flour substitution into the ration, significantly maintained the level of SOD serum equal to that of administrated with basal ration. The other stress oxidative parameters; malondialdehyde (MDA) and glutathione peroxidase (GSHPx) activities showed no differences between treatments. The administration of high cholesterol ration increased total cholesterol 16 fold as compared to those administrated with basal ration, and increased cholesterol LDL, and triacylglycerol level significantly. Co-administration
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Judul: Proses Peroksidasi Lipid Kelinci yang Hiperlipidemia pada Pemberian Senyawa Penurun Kolesterol
Abstrak: Free radicals, such as lipid peroxide, are having much attention right now because their significant role in degenerative disease. Hyperlipidemia is one of the major risk factor for atherosclerosis and lead to degenerative disease. The aim of this study was to determine the effect of cholesterol lowering substance to the blood peroxide lipid concentration in hyperlipidemic rabbit. Twenty four male New Zealand white rabbits were divided into four groups: normal (given standard rabbit feed), hyperlipidemia (given atherogenic rabbit feed contained 0.5% cholesterol and 5% coconut oil), lovastatin (given mixture of atherogenic rabbit feed and lovastatin 57 mg/day), and extract (given atherogenic rabbit feed and jati belanda leaves extract mixture). Thiobarbitnric acid (TBA) method was used in blood lipid peroxide analysis, measuring the MDA product by spectrophotometer at 532 nm. The result showed that the atherogenic rabbit feed caused the elevation of MDA concentration, which means the elevation of lipid peroxidation process. Blood lipid peroxide concentration in hyperlipidemia group increased 163.76% compared with normal group (1.30 ± 0.38 nmol/ml). Lovastatin and jati belanda leaves extract mixture can act as antioxidant which can lowering blood lipid peroxide concentration 46.92% and 53.03% respectively at 8th week compared with hyperlipidemia group.
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Judul: Formulasi Hamiltonian untuk Menggambarkan Gerak Gelombang Soliter Dimensi Tiga di Permukaan Laut
Abstrak: Gelombang permukaan adalah gelombang yang terjadi perbedaan rapat massa antara air dan udara. Salah satu gelombang permukaan yang ditinjau adalah gelombang soliter. Formulasi gelombang soliter dilakukan dengan menggunakan formulasi Hamiltonian.
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