Judul: Pedogenesis Seri-seri Tanah di Daerah Cibinong, Citeureup dan Kedunghalang, Kabupaten Bogor
Abstrak: Seri Tanah merupakan kategori terendah dari sistem Taksonomi Tanah, tersusun oleh pedon-pedon yang mempunyai horison yang serupa, dibentuk dari bahan induk yang sama oleh kombinasi proses genetik yang sama. Sifat-sifat yang dimilikinya sangat dipengaruhi oleh pedogenesisnya. Penelitian pedogenesis Seri Parung, Jembatan, Kempong dan Cijujung menunjukkan bahwa seri-seri ini sangat dipengaruhi lingkungan setempat.
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Judul: Pedogenesis dan Sifat-Sifat Tanah Disahakan dan Tidak Disawahkan Pada Berbagai Lereng di Sekitar Cibinong
Abstrak: Penelitian ini bertujuan untuk mengetahui pedogenesis dan sifat-sifat fisik dan kimia tanah yang disawahkan dan tidak disawahkan pada berbagai lereng di daerah sekitar Cibinong, Kabupaten Bogor. Penelitian ini dilaksanakan d i lapang dan d i laboratorium. Pengamatan morfologi tanah d i lapang dan pengambilan contoh tanah dilakukan pada tanggal 1 sampai 16 Agustus 1987, sedangkan analisa sifat-sifat fisik , kimia dan mineralogi tanah di laboratorium dilakukan pada tanggal 16 September 1987 sampai 2 Januari 1988. Penelitian ini dilakukan terhadap 5 pedon yang terdiri darh 3 pedon sawah yang terletak di puncak, lereng tengah dan lembah serta 2 pedon tidak disawahkan yang terletak di puncak dan lereng tengah.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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