Judul: Gambaran Toksikopatologi Organ Hati dan Ginjal Mencit C3H Pasca Pemberian Capsaicin
Abstrak: Capsaicin is the mayor compound founds in chilli peppers of the Capsicum genus. Capsaicin has been shown to have antiproliferative activity to intestine, liver, prostate, and leucocytes cancer cells in vitro. The liver and kidney are the main target of toxic effect. The research was conducted to know the effect of capsaicin to liver and kidney toxicopathology of C3H mice. Twelve mice strain C3H were divided into 3 groups. Groups 1 as a negative control were not administered capsaicin. Groups 2 were administered capsaicin for 2 weeks. Groups 3 were administered capsaicin for 4 weeks. The capsaicin was administered perorally with 10 mg/kgBW dose. Clinical observations made throughout the treatment period. Then, the mice euthanized and their organs were observed and preparated for histopathology stained hematoxylin-eosin (HE) and immunohistochemistry (CPI) using TNF-α antibody. The gross anatomy and histopathology showed that the mice treated capsaicin for 2 weeks showed average damage to the liver and kidney, while mice treated capsaicin for 4 weeks suffered severe damage to the liver and kidney. This shows the lack of security levels of capsaicin to the liver and kidneys.
Keyword: toxicopathology, liver, kidney, C3H mice, capsaicin, Bogor Agricultural University (IPB)

Judul: Studi Toksikopatologi Organ Hati dan Ginjal Mencit (Mus musculus) Akibat Pemberian Berbagai Fraksi Pauh Kijang (Irvingia malayana Oliv. Ex A. Benn).
Abstrak: The aim of this research was to examine the toxicopathology effect from various fractions of Irvingia malayana Oliv. Ex A. Benn on mice liver and kidney. Twenty five male mice age ±3 months with ±30 grams BW used in this research were divided into five group of treatments. Each mice from four groups of treatment was received 100 mg/kg BW fractions of I. malayana from chloroform solvent, ethyl acetate solvent, hexane solvent, and ethanol residue solvent, while one group control received carboxymethocellulose. After receiving 100 mg/kg BW fraction I. malayana for seven days, the mice then were sacrificed, the liver and kidney were sampled and fixed in Buffer Neutral Formalin 10% solution to make histopathology slides with Haematoxylin and Eosin stain. The histopathology slides were observed under light microscope. The lesion observed in the liver and kidney proximal tubular epithelium was degeneration and necrosis/apoptotic. The result from this research indicated that the dose of 100 mg/kg BW fraction of I. malayana from various solvent were not toxic to hepatocytes and proximal tubular epithelium.
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Judul: Hamiltonian formulation for linear waves motion in two layers fluid
Abstrak: The surface wave could be considered as a wave that separates two fluids, namely water and air. Based on this assumption, it is introduced the interfacial wave, a wave between two layers of fluid with different density. The formulation of interfacial waves motion begins with deriving the base equation of irrotational ideal fluid. Furthermore, according to irrotational fluid assumption, the base equation can be stated in velocity potential. In this derivation, the fluids domain is assumed to be restricted by rigid lid boundary conditions, both at the upper and lower limit. Therefore, the interfacial waves motion can be explained in a hamiltonian formulation. In the hamiltonian formulation, total energy is defined as the sum of kinetic and potential energy. The hamiltonian system is obtained from reduction of kinetic energy by using the Dirichlet Neumann Operator. The resulted kinetic energy equation is nonlinear. Therefore, this form is linearized by first part of the Taylor expansion. This linearization gives a dispersion relation of linear wave. Based on this dispersion relation, the phase speed of the linear wave depends on the density ratio of the two layers fluid.
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