Judul: Efektivitas pemberian glukosamin berbasis endoskeleton Cumi (Loligo sp.) sebagai antiosteoartritis pada Tikus Sprague Dawley
Abstrak: Osteoartritis merupakan suatu penyakit dengan perkembangan slow progressive, ditandai adanya perubahan metabolik, biokimia, struktur rawan sendi serta jaringan sekitarnya, sehingga menyebabkan gangguan fungsi pada sendi. Glukosamin diperlukan untuk pembentukan cairan pelumas dan agen perlindungan terhadap sendi pada penderita osteoartritis. Penelitian ini bertujuan untuk membuat serta menganalisis glukosamin dari bahan baku endoskeleton cumi (Loligo sp.) dan pengaruhnya sebagai antiosteoartritis pada tikus Sprague Dawley. Pembuatan glukosamin menggunakan metode hidrolisis bertekanan. Karakterisasi kitosan menghasilkan derajat deasetilasi sebesar 85,31%. Derajat deasetilasi dan rendemen glukosamin pada penelitian ini sebesar 92,05% dan 90-99%. Pengamatan mikroskopis, secara histopatologi menunjukkan bahwa glukosamin komersil lebih baik dari pada glukosamin endoskeleton cumi (Loligo sp.), dengan nilai rataan masing-masing sebesar 2 (kategori sedang) dan 1,75 (kategori sedang). Hasil tersebut mengindikasikan bahwa glukosamin endoskeleton cumi (Loligo sp.) dapat menurunkan gejala penyakit osteoartritis…
Keyword: Deacetylation value, Endoskeleton of squid, Glucosamine, Osteoarthritis, Fisheries, Metode hidrolis bertekanan, Cairan pelumas

Judul: Recovery glukosamin hidroklorida dari cangkang udang melalui hidrolisis kimiawi sebagai bahan sediaan suplemen osteoartritis
Abstrak: Glukosamin hidroklorida (GlcN HCl) merupakan monomer dari kitin dan telah banyak dimanfaatkan dalam bidang kesehatan terutama sebagai suplemen penyakit osteoarthritis. Senyawa ini dapat dihidrolisis dari limbah kulit udang karena kandungan kitinnya cukup tinggi. Beberapa penelitian hidrolisis glukosamin hidroklorida yang telah dilakukan memiliki tingkat permasalahan yang berbeda, diantaranya adalah rendemen yang dihasilkan sangat rendah, proses hidrolisis sulit dan memiliki risiko kegagalan yang relatif tinggi, serta biaya produksi yang cukup tinggi. Tuntutan kebutuhan akan kondisi optimal proses masih sangat diperlukan. Selain itu, produksi glukosamin di Indonesia masih belum ada dan banyak diimpor dari negara lain dengan harga yang tinggi. Penelitian ini bertujuan mengekstraksi glukosamin hidroklorida dari kulit udang melalui hidrolisis kimiawi dan menganalisis tingkat konsentrasinya untuk sediaan suplemen penyakit osteoarthritis.
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Judul: Thermal Characteristics and Dynamics of Tropical Cyclone over Western North Pacific Ocean: A Case Study of Typhoon Songda (Chedeng) 2011
Abstrak: The frequent occasion of Tropical Cyclone (TC) over Western North Pacific (WNP) Ocean lies from 10˚N to 26˚N and 121˚E to 170˚E. Sources of TC development come from warm ocean temperature where latent heat is released during condensation processes and subsequently concentrated in the boundary layer. Relative humidity at 850-700 hPa is responsible to produce the most intense storm. Meanwhile, weak vertical wind shear between 850-200 hPa is one of the dynamical factors that lead to the development of TC. Pressure level of 850-200 hPa is chosen to minimize the thermodynamic effect in the lower troposphere. Typhoon Songda (Chedeng in the Philippines) or TSC lasted from May 18th to 30th, 2011 and strengthened into powerful Super Typhoon stage between May 24th and 27th. Long curving track and the exhibition of all sequences of TC life cycle, TSC is then considered as an ideal case of TC. The objective of the study with case of TSC is to investigate the role of thermal characteristics and dynamics on TC intensity. The research is carried out by using Advanced Research of Weather Research and Forecasting model (WRF ARW model) version 3.3. Two domains are employed in the model. The first domain situate from 02˚N to 40˚N and 118˚E to 149˚E and cover spatial resolution () of 33.1 km. The second domain situate from 09˚N to 27˚N and 119˚E to 132˚E with of 11 km. Timestep of the model () is 120 seconds. The model is supported by the following physical parameterization, i.e., Yonsei University Scheme (YSU) in the boundary layer, Kain-Fritsch scheme (KF) in the cumulus, and WRF Single-Moment 3-class scheme in the microphysics. Initial meteorological condition prior to the formation of the cyclone is generated using WRF ARW standard-release model. Sensitivity of the model output is obtained from a selected single-parameter change scenarios, namely, 10 % to 20 % decrease and increase of wind shear initial data at 850-200 hPa, and by 10 % to 20 % decrease of relative humidity initial data at 850-700 hPa. The result showed that the negative correlations between wind shear and intensity are found in wind shear scenarios. Wind shears of 10 ms-1 which lead to strengthening of the wind intensity in the early period of Typhoon development are found in wind shear scenarios. The effect of wind shear changes on wind intensity is statistically significant in the 20 % wind shear scenarios. During mature stage, weak wind intensity occurred when wind shear increase as given in the WRF standard-release and the 20 % decreasing scenario. Different situation is found in the 20 % increasing scenario where wind shear tend to weak and lead to strong wind intensity at this stage. Meanwhile, the reduction of moisture supply at 850-700 hPa resulting from 20 % decreasing relative humidity play a major role in the weakening of wind intensity and reduces mechanical energy of the cycle process as much as 300 J kg-1.
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