Judul: Teknik Ensemble Docking Pada Senyawa Aktif Tanaman Tapak Dara Sebagai Potensi Anti Malaria Dengan Target PfDTD
Abstrak: Malaria merupakan salah satu penyakit endemik yang cukup mematikan di dunia hingga saat ini. Upaya dalam mengurangi penyakit malaria telah banyak dilakukan baik melalui pemberantasan terhadap vektornya maupun pemberantasan terhadap parasitnya melalui obat sintetik ataupun obat yang berasal dari tanaman herbal alami. Namun bahaya resistensi dan efek samping yang ditimbulkan juga tidak dapat diabaikan. Oleh karena itu, dibutuhkan alternatif obat antimalaria baru yang cukup terjangkau dan efektif. Salah satu tanaman obat yang diyakini memiliki khasiat sebagai tanaman obat antimalaria adalah Tanaman Tapak Dara. Penelitian ini menggunakan metode in silico melalui proses redocking, docking dan proses virtual screening pada 22 senyawa ligan tanaman tapak dara terhadap 6 reseptor target PfDTD yang kemudian diseleksi sehingga diperoleh 5 senyawa ligan terbaik. Bedasarkan hasil penelitian yang diperoleh ditemukan bahwa senyawa ligan tanaman tapak dara dengan kode ligan 19_CID_163025450 memiliki nilai afinitas terendah serta memiliki ikatan yang cukup kuat dan relatif stabil., Malaria is one of the world’s lethal diseases nowadays. Various ways to reduce malaria have been done by eradicating the vector and the parasite which using synthetic or natural drugs. But, the resistance and the side effects from those drugs can not be ignored. So that, the alternatives of anti malaria drugs which are more affordable and effective are needed. One of the plants which potentially has medicinal property as an anti malaria is Cape Perwinkle plant. The study was using in silico methods through redocking, docking and virtual screening process on 22 active compounds of Cape Perwinkle with 6 PfDTD targets receptors that would be selected into 5 best ligands. Based on this research, one of the Cape Perwinkle active compounds with ligand code 19_CID_163025450 has the lowest affinity value, and also has quietly strong and relatively stable bonds.
Keyword: Malaria, Cape Perwinkle, PfDTD, redocking, docking, virtual screening, affinity value

Judul: Virtual Screening Senyawa Obat Antimalaria dengan Target PfODC Berbasis Energi Ikat
Abstrak: Malaria merupakan salah satu dari masalah kesehatan utama di seluruh dunia. Ada beberapa metode yang digunakan dalam menanggulangi malaria, diantaranya adalah pengendalian vektor nyamuk, penggunaan kelambu, dan vaksin. Saat ini, penggunaan obat dibutuhkan dalam pengendalian malaria. Pada penelitian ini dilakukan penambatan dan simulasi dinamika molekul antara Plasmodium falciparum orotidin 5'-monofosfat dekarboksilase (PfODC) dengan senyawa alami dari berbagai tanaman. Hasil simulasi dinamika molekul menunjukkan bahwa senyawa strychnopentamine memilki potensi sebagai inhibitor dengan nilai energi bebas ikat sebesar -64.7 kkal mol-1 dan kestabilan yang baik berdasarkan nilai RMSD, RMSF, dan jari-jari girasi dalam rentang waktu 100 ns.
Keyword: orotidin 5’-monofosfat dekarboksilase, penambatan molekul, simulasi dinamika molekul, energi ikat

Judul: Quality of Eggs Based on Different Age of Chickens from Yong's Farm, Seremban, Malaysia
Abstrak: This study aimed to determine the quality of eggs from different ages of chickens from Yong’s Farm, Seremban, Malaysia. The method used was 60 eggs were collected from three of different ages of chicken; 25 (n=20 eggs), 35 (n=20 eggs) and 58 weeks old (n=20 eggs). The variables included egg weight, shell thickness, yolk color, yolk index, albumen index and Haugh unit. The results showed the highest egg weight was recorded with 58 weeks old chicken. The egg shell thickness found at week 25 week (0,455 ± 0,08 mm), 35 weeks (0,495 ± 0,08 mm) and 58 weeks (0,475 ± 0,08 mm). Yolk color was at the highest mean of.12,6 ± 0,68 (25 weeks) while on week 35 and 58 it ranges between 5,45 ± 0,51 and 5,55 ± 0,51. The yolk index was recorded on week 25 and no specific trends were observed and the yolk index was not significant between 35 and 58 weeks of age. Albumen index was highest at week 25 were (0,129 ± 0,0), week 35 (0,113 ± 0,03) and week 58 (0,088 ± 0,02). The highest HU was recorded at week 25 (94,81 ± 5,33) and decreased to (90,52 ± 6,64) at week 35 and (81,95 ± 6,24) at week 58. It can be concluded that chicken influences both exterior and interior quality, except the yolk color with the quality of eggs decreasing as the age increases.
Keyword: chicken age, external quality, internal quality, Haugh Unit