Judul: Respon laju respirasi mitokondria terhadap pemberian ekstrak kasar tanaman afrodisiak
Abstrak: Aphrodisiac is believed can increase human stamina and sexuality enhancement. The mechanism can be performed in hormonally and non hormonally way. Hormonal mechanism is thought to be related to cell respiration in mitochondria. The objective of this research was to know the effect of aphrodisiac plant crude extract addition to the mitochondria respiration rate, especially Krebs cycle. Fresh mitochondria was isolated from the liver, kidney and limph of Wistar strain rat. Several plants that used in this research were ginseng (Panax ginseng), pasak bumi (Eurycorna longijolia), cabe jawa (Pepper retrofracttrm), kayu lanang (Oroxylttnt indicttm), tapak liman (Elephantophris scaber) dan purwoceng (Pimpinella prtraljan). Oxidation rate was measured by the ratio of NADH and NADi and performed by ultraviolet spectrophotometer. Aphrodisiac plant crude extract addition to the fresh mitochondria isolate generally decrease its respiration rate, especially by the addition of ginseng, cabe jawa, tapak liman, and kayu lanang. These plant extract addition caused a lower oxidation rate than the control treatment almost in every concentration that used in this research. The control oxidation rate value was 0.620.
Keyword: 

Judul: Studi In Silico Pengaruh Senyawa Afrodisiak Cabai Jawa  (Piper retrofractum Vahl) Terhadap Peningkatan Libido  Sapi Jantan
Abstrak: Cabai jawa telah lama dikenal sebagai afrodisiak, namun mekanisme kerjanya belum diketahui. Penelitian ini bertujuan mengetahui interaksi senyawa aktif cabai jawa dengan fosfodiesterase tipe 5 (PDE5) (ID: 1UDT) dan menentukan senyawa yang memiliki potensi afrodisiak sebagai inhibitor PDE5 melalui pendekatan in silico. PDE5 sebagai reseptor dan ligan-ligan uji dipreparasi menggunakan software Discovery Studio dan AutoDock Vina. Lima ligan uji guineensine, piperin, piperlongumin, β-sitosterol, dan filfilin dibandingkan dengan sildenafil sitrat setelah diuji stabilitas dan toksisitas ligan. Pemilihan kelima ligan didasari kemiripan struktur ligan dengan hormon steroid. Hasil analisis penambatan molekuler menunjukkan ligan uji yaitu β-sitosterol memiliki nilai ΔG lebih kecil dibandingkan sildenafil sitrat sebesar -10 kkal/mol serta β-sitosterol dan piperin memiliki aktivitas penambatan terbaik dengan %BSS sebesar 63,6% berdasaran analisis visualisasi 2D dan 3D. β-sitosterol dan piperin berpotensi sebagai afrodisiak dengan bekerja sebagai inhibitor PDE5., Java long pepper (Piper retrofractum Vahl) has known for many years as aphrodisiac in traditional medicine, however the molecular mechanism of this action is not very clear. This study is focused to figure out the interactions between active compounds of long pepper and phosphodiesterase type 5 (PDE5) (ID: 1UDT) and which compounds have aphrodisiac potential as PDE5 inhibitor in silico. PDE5 as receptor and tested ligands were prepared using Discovery Studio and AutoDock Vina. Five tested ligands including guineensine piperine, piperlongumine, β-sitosterol, and filfiline was compared to sildenafil citrate after stability and toxicity test. The five ligand was elected by the structure similarity to steroid hormones. The result of molecular docking showed tested ligands β sitosterol with smaller value of ΔG (-10 kcal/mol) than sildenafil citrate. Piperine and β-sitosterol had best docking activity with %BSS value of 63,6%. β-sitosterol and piperine has potential as aphrodisiac by acting as PDE5 inhibitor.
Keyword: afrodisiak, cabai jawa, in silico, PDE5, sapi jantan

Judul: Construction of Strongly Optimal Binary Linear Code with Minimum Distance 9 and 11
Abstrak: A binary linear code of length n over q F is a subspace of n q F . A code has three parameters that attached to it, namely length, dimension, and minimum distance. A code with length n, dimension k and minimum distance d is often called [n, k, d ]-code. Usually, when two parameters are given, then we want to find a code that has the best value for the last parameter. Based on Gilbert- Varshamov bound, if a [n, k, d ]-code exists and can not be expanded, we call it a strongly optimal code. In this paper, we construct strongly optimal code with minimum distance 9 and 11. In constructing the code, we created a theorem and algorithm based on Gilbert-Varshamov bound before we implement the algorithm to MAPLE programming language. Because of computational limitations, the program can only construct up to k = 10 for d = 9 and k = 12 for d = 11.
Keyword: