Judul: Aktivitas Inhibisi Enzim α-Glukosidase dan Sitotoksisitas Ekstrak Kurkuminoid Rimpang Temulawak dari Berbagai Aksesi (In Vitro)
Abstrak: Temulawak (Curcuma xanthorriza Roxb.) is one of the Zingiberaceae family medicinal plants that grow in Indonesia. Temulawak rhizome contains curcuminoid which useful as an antidiabetic. This research aims to get temulawak accession with high capability of the inhibition activity of the α-glukosidase enzyme and it’s potential as a compound that toxic to shrimp’s larval Artemia salina Leach. Antidiabetic activity has been measured by formation of p-nitrophenol from enzymatc reaction of nitrophenil-α-D-glucopyranose (p-NPG) which is catalyze by α-glucosidase enzyme. The formation of p-nitrophenol was measured by spectrophotometer at λ=410 nm. The results of curcuminoid content and bioactivity assay (α-glukosidase enzyme inhibition and cytotoxicity) showed that the best accession of temulawak is Wonogiri’s accession. The value of curcuminoid content, IC50, LC50, from Wonogiri’s accession of temulawak rhizome extract, respectively for 85.19±4.64 mg/g, 333±22.52 μg/mL, and 82.78±7.70 μg/mL. Wonogiri’s accesion has the potential to be further researched and developed as a new variety.
Keyword: Bogor Agricultural University (IPB), cytotoxicity, curcuminoids, antidiabetic, Curcuma xanthooriza

Judul: Aktivitas Inhibisi Terhadap Siklooksigenase, Kadar Pati dan Fenolik Temulawak (Curcuma xanthorriza Roxb.) Aksesi Sukabumi
Abstrak: Curcuma xanthorrhiza Roxb. known as temulawak is widely used as herbal medicinal plant that has many benefits, including antiinflammation. The objectives of this research were to evaluate inhibitory activity of temulawak Sukabumi accession toward cyclooxygenase-2 (COX-2) and to analyze its correlation with starch and phenolic level. The extraction method used maseration with ethanol 70%. The starch level was analyzed using Luff-scohrl’s method, and the phenolic level was determined using the Folin-Ciocalteu’s. The starch level is relatively higher (P>0.05) on temulawak Cursina variety were 23.05%±3.49, while the phenolic level is relatively higher (P>0.05) on temulawak Sukabumi accession were 81.16 mg/g±19.68. Both of temulawak extracts showed inhibitory activity against COX-2. The highest activity (P>0.05) on temulawak Sukabumi accession with inhibition value of 55.35%. Based on analysis of corelation, the phenolic compound has antiinflammation activity, while starch will reduce antiinflammation activity.
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Judul: Construction of Strongly Optimal Binary Linear Code with Minimum Distance 9 and 11
Abstrak: A binary linear code of length n over q F is a subspace of n q F . A code has three parameters that attached to it, namely length, dimension, and minimum distance. A code with length n, dimension k and minimum distance d is often called [n, k, d ]-code. Usually, when two parameters are given, then we want to find a code that has the best value for the last parameter. Based on Gilbert- Varshamov bound, if a [n, k, d ]-code exists and can not be expanded, we call it a strongly optimal code. In this paper, we construct strongly optimal code with minimum distance 9 and 11. In constructing the code, we created a theorem and algorithm based on Gilbert-Varshamov bound before we implement the algorithm to MAPLE programming language. Because of computational limitations, the program can only construct up to k = 10 for d = 9 and k = 12 for d = 11.
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