Judul: Karakteristik dan efektivitas penetrasi kafein terjebak dan tersalut nanopartikel kitosan sebagai antiselulit
Abstrak: Chitosan used as drug carrier because of is natural polycationic and easily modified in chemical and physical properties. In this research chitosan was chemically modified by coating and entrapping anti-cellulite active substance of caffeine and physically modified by minimizing chitosan particle size into nanoparticles size. The purpose of this research is to characterize the chitosan nanoparticles from its morphology, particle size, function of group, the value of adsorption efficiency, and effectiveness of chitosan nanoparticles against in vitro penetration of caffeine as anti-cellulite using Franz diffusion cell. The morphology characterization test of caffeine trapped in chitosan nanoparticles and caffeine coated by chitosan nanoparticles resulting a smooth surface, slight convex shape, and agglomerated particles; average size of particles are 232.74 nm and 226.62 nm respectively; the function group showed a shift of wave number of amide III groups (-CN) and hydroxyl groups (-OH); the caffeine adsorption efficiency are 51,35% and 64,63% respectively. The result of effective penetration are 1.089.65 ± 10.7 μg/cm2 and 2.170.03 ± 6.85 μg/cm2 respectively.
Keyword: chitosan nanoparticles., chitosan, caffeine, anti-cellulite

Judul: Nanoencapsulation of Phycocyanin from Spirulina platensis Using Chitosan with Different Polymer Lengths for Transdermal Delivery Applications
Abstrak: Fikosianin dari Spirulina platensis memiliki sifat bioaktif seperti antioksidan dan antikanker, tetapi kemurniannya sulit dicapai dengan metode konvensional. Sistem aqueous two phase dengan Natural Deep Eutectic Solvent (NaDES) menawarkan pemurnian lebih efisien. Tantangan stabilitas dan berat molekul tinggi diatasi dengan nanoenkapsulasi menggunakan kitosan. Penelitian ini menentukan metode pemurnian terbaik dan formulasi nanopartikel fikosianin-kitosan, serta mengevaluasi pengantaran transdermal dan aktivitas bioaktifnya. Hasil menunjukkan formula nanopartikel terbaik adalah NPC-LC dengan ukuran partikel 275,43 nm. Aktivitas antioksidan meningkat, dan nano-fikosianin tidak toksik terhadap sel normal, tetapi efektif melawan sel kanker melanoma., Phycocyanin from Spirulina platensis possesses bioactive properties such as antioxidant and anticancer activities, but its purity is challenging to achieve using conventional methods. The aqueous two-phase system with natural deep eutectic solvents (NaDES) offers more efficient purification. The challenges of stability and high molecular weight are addressed through nanoencapsulation using chitosan. This study determines the best purification method and the formulation of phycocyanin-chitosan nanoparticles, as well as evaluates their transdermal delivery and bioactive activity. Results showed that the best nanoparticle formulation is NPC-LC with a particle size of 275.43 nm. Antioxidant activity increased, and nano-phycocyanin is non-toxic to normal cells but effective against melanoma cancer cells.
Keyword: antioxidant, aqueous-two-phase, microalgae, NaDES, purification

Judul: Populasi, Identifikasi dan Keragaman Jenis Burung Peliharaan Di Kotamadya Bogor
Abstrak: Jumlah dan jenis buruog mengalami penwunan setiap saat akibat perburuan dan kehilangan habitat alarninya. Habitat alami burung hilang karena hulan berkurang dan beberapa tempat yang berfungsi sebagai penyokong kehidupan burung sudah tidak ada lagi. Untuk itu diperlukan inforrnasi terbaru mengenai jumlah dan jenis burung terutama yang dipelihara karena sebagian besar burung peliharaan adalah hasil tangkapan di alamo
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