Judul: Perubahan penggunaan lahan/penutup lahan dan struktur perubahannya  : Studi kasus Kecamatan Tigaraksa, Kabupaten Tangerang, Banten
Abstrak: Peningkatan penduduk yang sangat cepat disertai peningkatan pendapatan per kapita masyarakat telah mengakibatkan kebutuhan akan lahan untuk berbagai aktivitas yang berkaitan dengan pemenuhan kebutuhan sandang, pangan, dan papan semakin meningkat. Tangerang sebagai salah satu hinterland dari Jakarta telah mengalami perubahan penggunaan lahan yang intensif, namun belum banyak penelitian yang mendukung fenomena tersebut. Kecamatan Tigaraksa merupakan kecamatan yang mengalami perubahan penggunaan lahan relatif terbesar dibandingkan kecamatan lain di Kabupaten Tangerang pada periode tahun 1993 dan 2001. Penelitian ini menggunakan citra Landsat TM sebagai produk kemajuan ilmu pengetahuan dan teknologi, yang mampu menyajikan data dan informasi secara periodik dalam waktu yang relatif lebih cepat dan meliputi wilayah yang luas. Tujuan penelitian ini adalah: (1) Analisis perubahan penggunaan lahan/penutup lahan di Kecamatan Tigaraksa, Kabupaten Tangerang, Banten tahun 1993 dan 2001, (2) Analisis keterkaitan antara perubahan penggunaan lahan, perkembangan fasilitas umum dan pertumbuhan penduduk, serta (3) Analisis struktur perubahan penggunaan lahan di Kecamatan Tigaraksa, Kabupaten Tangerang, Banten. ...
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Judul: Dinamika Perluasan Perkotaan : Hubungan Perubahan Tutupan Lahan dengan Bentuk Perkotaan Wilayah Kabupaten Tangerang
Abstrak: Kabupaten Tangerang tergabung dalam wilayah metropolitan Jabodetabek mengalami fenomena perluasan perkotaan akibat proses urbanisasi dan suburbanisasi yang mengarah terjadinya urban sprawl dan pertumbuhan fisik perkotaan semakin tidak terkendali. Informasi urban form diperlukan agar proses perencanaan pengembangan wilayah dapat terarah dan berkelanjutan berdasarkan karakteristik pola spasial yang terbentuk. Perubahan tutupan lahan sebagai dampak perluasan perkotaan diamati pada level kecamatan setiap wilayah pengembangan (WP) berdasarkan hirarki struktur ruang RTRW Kabupaten Tangerang yang dibagi menjadi 3 wilayah pengembangan yaitu WP I, II dan III. Penelitian bertujuan: 1) menganalisis trend urban expansion dalam bentuk perubahan tutupan lahan, 2) mengidentifikasi karakteristik urban form dan 3) menganalisis keselarasan antara tutupan lahan dengan pola ruang RTRW Kabupaten Tangerang. Analisis perubahan tutupan lahan dilakukan dengan overlay peta tutupan lahan tahun 2015 dan 2020 serta tabulasi matriks perubahan tutupan lahan (crosstab), karakteristik urban form di analisis dengan Spatial Metric menggunakan variabel density, continuity, clustering, dan shape serta analisis keselarasan dilakukan dengan overlay antara peta tutupan lahan dengan RTRW Kabupaten Tangerang. Perubahan tutupan lahan terjadi peningkatan luas pada tutupan lahan terbangun dan badan air serta penurunan luas pada tutupan lahan kering, sawah dan vegetasi lainnya. Karakteristik urban form tutupan lahan sawah dan lahan terbangun berdasarkan WP I berbentuk sprawl. Karakteristik urban form berdasarkan WP II tutupan lahan terbangun konstan dan lahan sawah berbentuk compact. Tutupan lahan terbangun WP III berbentuk sprawl, sedangkan pada lahan sawah berbentuk compact. Nilai keselarasan Kabupaten Tangerang termasuk kategori sangat tinggi (88%) dengan jenis ketidakselarasan terluas yaitu peruntukan kawasan pertanian dengan tutupan lahan terbangun (Kawasan Pertanian-LTB)., Tangerang Regency which is part of the Jabodetabek metropolitan area experiencing the phenomenon of urban expansion due to the process of urbanization and suburbanization can lead to urban sprawl and uncontrolled urban physical growth. Urban form information is needed so that the regional development planning process can be directed and sustainable based on the characteristics of the spatial pattern that is formed. Changes in land cover as a result of urban expansion are observed at the sub-district level of each development area (WP) based on the spatial structure hierarchy of the Tangerang Regency RTRW which is divided into 3 development areas, namely WP I, II, and III. This research aims: 1) to analyze urban expansion trends in the form of land cover changes, 2) to identify the characteristics of the urban form, and 3) to compare the characteristics of the urban form to the RTRW of Tangerang Regency. The land use change analysis carried out with 2015 and 2020 land cover maps overlay and change matrix tabulation land cover (crosstab), urban form characteristics were analyzed using Spatial Metric density index, continuity, clustering/fragmentation, and shape, and alignment analysis were carried out by overlaying between maps land cover with RTRW Tangerang Regency. Changes in land cover increased the area of built-up land and water bodies and a decrease in the area of dry land, paddy fields, and other vegetation. Characteristics of urban form on paddy field cover and built-up land based on WP I are in the form of sprawl. Characteristics of urban form based on WP II constant built-up land cover and compact
Keyword: compact, development area, land conversion, spatial metric, sprawl

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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