Judul: Perencanaan Jalur Hijau Perumnas Kota Baru Driyorejo Gresik, Jawa Timur
Abstrak: Perumnas Kota Baru Driyorejo (KBD) merupakan salah satu alternatif yang ditawarkan Perum Perumnas cabang Driyorejo untuk memenuhi kebutuhan akan pemukiman yang ideal dan layak huni. Perumnas tersebut berupa disain bebas tapi terbatas (open ended design) Lingkungan Siap Bangun (LISIBA) yang merupakan bagian dari Kawasan Siap Bangun (KASIBA), yang pembangunannya saat ini kurang lebih sudah mencapai 80%.
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Judul: Rencana pengelolaan tata hijau di Kota Baru Bandar Kemayoran, Jakarta
Abstrak: Kota Baru Bandar Kemayoran (KBBK) memiliki luasan areal +- 454 ha. Kota Baru Bandar Kemayoran (KBBK) menempati tapak yang pada mulanya adalah bandar udara internasional yang sangat ramai pada zaman pemerintahan Belanda, yang kemudian ditutup pada tanggal 1 Oktober 1985. Kawasan ini memungkinkan bagi pembangunan suatu kota baru yang perencanaannya dilakukan secara menyeluruh, terpadu, meliputi suatu koordinasi yang baik antara pembangunan lingkungan pemukiman, lapangan kerja/ perkantoran, fasilitas sosio-kultural dan sarana prasarana kepentingan umum lainnya. Pengembangan kawasan KBBK ini diharapakan mampu memiliki dan memperbaiki lanskap kota yang baik. Berdasarkan Keputusan Presiden RI No. 53 tahun 1985 dibentuklah Badan Pengelola Komplek Kemayoran (BPKK) yang diketuai oleh Menteri Sekretaris Negara untuk pembangunan kawasan ini.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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