Judul: Simulasi Kinematika Insulin dan Glukosa Darah pada Diabetes Gestasional Dengan Menggunakan Persamaan Minimal Model termodifikasi
Abstrak: Kinematika gerak insulin dan glukosa pada kasus dibetes gestasional didasarkan pada persamaan kelajuan minimal model dari Bergmann. Diabetes Mellitus Gestasional disebabkan oleh adanya hormon plasenta sehingga mempengaruhi metabolisme glukosa pada wanita hamil (gangguan metebolisme glukosa). Kinematika glukosa dan insulin ini disimulasikan menggunakan software matlab R2012b. Metode yang dilakukan adalah dengan menggunakan ode 45, dan persamaan yang dipakai adalah persamaan minimal model Bergmann, dengan nilai korelasi yang diperoleh lebih dari 85%. Kisaran SI (efektivitas insulin) dan SG (efektivitas glukosa) Diabetes Mellitus Gestasional adalah 1.49 ±0.37 dan 0.022 ± 0.002 menit-1. sedangkan kisaran SI dan SG untuk kontrol adalah 3.11 ± 0.73 dan 0.021 ± 0.003 menit-1.
Keyword: diabetes, mellitus, gestasional, ode 45, Sensitivitas Insulin, Sensitivitas Glukosa, SI, SG

Judul: Simulasi Kinematika Terapi Diabetes Tipe 1 Menggunakan Minimal Model Termodifikasi
Abstrak: Mathematical modelling of glucose-insulin system in the human body is one of the interesting topic in physics of complex systems. It can be used as a therapeutic treatment of diabetes mellitus type 1. The function of exogenous glucose and insulin are important factors in maintaining the body’s metabolism, especially are the blood sugar’s consentration. Minimal model was modified with adding of exogenous glucose F(t) and insulin U(t) function that obtained from the differential equations by Nilam et al. Arrangement of glucose and insulin injection quantity and arrangement of time of injection time could affect the kinematics of glucose-insulin system in the blood. Based on our results, the optimum therapeutic treatment was obtained by first giving exogenous insulin at 560 μU/(mL.min) in the period t>0 to t<16 minutes. The values of exogenous glucose were given by 47 and 23 mg at injection time t0=7 min and t0=15 min. Finally, exogenous insulin was given at 38.1 μU/(mL.min) in the period t>35 to t<180 min, in the IVGTT during 200 min. The value of r2 at the graph was 0.981.
Keyword: type 1 diabetes, therapy, exogenous insulin, exogenous glucose, minimal model

Judul: Posisi Filogenetik Kura-Kura Carettochelys Insculpta  (Reptillia: Testudinata)
Abstrak: Carettochelys insculpta is an endemic freshwater turtle of southern Papua and northern Australia. Phylogenetic position of this turtle is remain unresolved until now. Most of the research conducted show close relationships of C. insculpta and members of Trionychidae family. However, some of the research show distance between C. insculpta and members of Trionychidae family. This research is conducted to analyze phylogenetic relationship between C. insculpta and other members of Testudinata using 12S rRNA, 16S rRNA, and both gene as markers. DNA samples were obtained from three different organisms of C. insculpta. Two species used as outgroups were Alligator mississippiensis and Iguana iguana. Phylogenetic analysis was carried out using Neighbor-Joining method with Felsenstein 1981 (F81) modeltest. A polytomy tree of Testudinata was produced by using 12S rRNA gene. However, analysis using 16S rRNA and both genes as markers confirmed that C. insculpta was located between the Chelonidae and the Trionychidae family.
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