Judul: Peranserta Lembaga Swadaya Masyarakat dalam Pembangunan di Pedesaan (Studi Kasus di Desa Mandah dan Purwosari, Kecamatan Natar, Kabupaten Lampung Selatan)
Abstrak: Menurut Mubyarto (1988) ketimpangan pendapatan desa-kota secara keseluruhan selama periode ber-Pelita 1969-1987 terus meningkat. Menurut Foerbo dan Nordholt (1983) hal ini disebabkan karena pembanqunan telah berhasil mendorong sektor moderen dalam masyarakat kota berkembang cepat. sedangkan di desa proses perubahan berjalan relatif lambat, hingga akhirnya menimbulkan kesenjangan yang potensial. Kondisi ini telah menggugah kesadaran masyarakat terhadap pembangunan yaitu mereka yang tergabung dalam organisasi kemasyarakatan yang disebut Lembaga Swadaya Masyarakat (LSM).
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Judul: Tinjauan Kemandirian Lembaga Swadaya Masyarakat
Abstrak: Penelitian ini bertujuan untuk mendeskkripsikan faktor-faktor yang menentukan kemandirian lembaga swadaya masyarakat serta untuk mengetahui peranan pembinaan oleh lembaga pengembangan swadaya masyarakat dalam menunmbuhkan motivasi kemandirian lembaga swadaya masyarakat. kasus dalam penelitian ini adalah kelompok usaha bersama ekonomi (KUBE) Kopeng Desa Karangpari Kecamatan Rancah Kabupaten ciamis, Jawa Barat. Penelahaahan dilakukan terhadap keragaan sistem sosial masyarakat, program pembinaan oleh Yayasan Bina Lingkungan Hidup, Program pembiaan oleh Yayasan Bina LIngkungan Hidup, motivasi Kemandirian dan dimensi-dimensi kemandirian kelompok yang diukur dari partisipasi dan kepercayaan anggota, permodalan, pengelolaan dan proses pengambilan keputusan.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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