Judul: Hidrolisat Protein Tempe Komak ((Lablab purpureus (L.) Sweet) sebagai Penghambat ACE (Angiotensin Converting Enzyme)
Abstrak: Unbalanced condition of local soybean production and consumption causes the increasing dependence through import soybean. The alternative to overcome this problem is to utilize another vegetable protein source as soybean substitution is needed. One of those protein is the komak nut toward ACE. The obstruction activity of komak nut hydrolyzate was analyzed in vitro involving three treatments, they were hydrolyzates of whole grain of komak tempeh, hydrolyzates of unpride komak tempeh, and hydrolyzates of steamed komak tempeh. Soybean analysis was also done due to compare the obstruction activity toward ACE with the same analysis done for komak nut. The result showed that unpride komak tempeh was more potential as ACE inhibitor compared to soybean. The IC50 value of unpride komak tempeh and soybean were 0.64 mg/g and 1.69 mg/g.
Keyword: tempeh., komak nut, Angiotensin Converting Enzyme

Judul: Aktivitas Inhibisi Enzim Pengubah Angiotensin pada Hidrolisat Tempe Koro Pedang (Canavalia ensiformis L.) secara In Vitro
Abstrak: Tempe is one of the processed food that has ACE (Angiotensin Converting Enzyme) inhibitory activity. This study aims to measure the activity of ACE inhibition in jack bean in vitro. Proximate analysis used AOAC method (2005) and hydrolyzed by gastrointestinal simulation (GIS) digestions, and then tested the degree of hydrolysis by Benjakul & Morrissesey modification method. Measurement of ACE inhibitors, based on the rate of formation of hippuric acid from substrate hippuryl-L-histidyl-L-leusine (HHL). Proximate analysis showed fat value of jack bean is lower than soybean and carbohydrate value is higher than soybean. Degree of hydrolysis (DH) of tempe from jack bean showed good results which amounted to 10.62% for crude tempe and 16.24% for steamed tempe. Of the IC 50 values obtained, crude tempe 50% more effective at inhibiting the activity of ACE by 0.26 mg/g sample. However, for the steamed tempeh also obtain poor results, because of the results obtained IC50 1:11 mg/g sample.
Keyword: tempe, in vitro, inhibition, jack bean, HHL, ACE

Judul: A Continuous Vaccination Strategy in the SVIR Epidemic Model
Abstrak: Vaccination is conducted to minimize the spread of a disease. The vaccination is usually done several times within a fixed time interval. In the SVIR model, it is assumed that individuals do not get immediate immunity following a vaccination program. So according to process of vaccination on SVIR model, there are two strategies, i.e. the continuous vaccination strategy (CVS) and the pulse vaccination strategy (PVS). In this study, only the CVS strategy in epidemic model SVIR is considered. Results of the study indicate that dynamics of the CVS system depends on the basic reproductive number. If the basic reproductive number is less than one, then the disease-free fixed point is asymptotically stable. It means that the disease will eventually disappear from the population. Conversely, if the basic reproductive number is greater than one, then the endemic fixed point is asymptotically stable, which means that the disease will remain exist in the population. Simulation result shows that the vaccination would minimize the spread of disease by reducing the basic reproductive number. If the time for the vaccinated recipients to obtain the immunity, as well as a possibility of vaccinated recipients to be infected are neglected, then the disease will be eradicated. This condition is called an over-evaluating effect of vaccination.
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