Judul: Konsentrasi Hambat Minimum dan Toksisitas Senyawa Hasil Biotransformasi Kurkumin oleh Mikrob Endofit Asal Kunyit
Abstrak: Curcumin can be transformed into its derivative compound with the help of endophytic microbes. The biotransformed compound has been known to possess antibacterial activity toward Salmonella typhi and Staphylococcus aureus. This research was conducted to determine the Minimum inhibition concentration (MIC) of the biotransformed compound using agar diffusion method to find out Salmonella typhi's and Staphylococcus aureus's sensitivity against the biotransformed compound. In addition, the toxicity test based on lethal concentration 50 (LC50) with the Brine shrimp lethal test (BSLT) method against Artemia salina was performed as preliminary test in determining the biotransformed compound’s potency in the development of medicines. The MIC value of this compound against Salmonella typhi was 6.25 mg/mL with the clear zone diameter of 2.5 mm and 25 mg/mL against Staphylococcus aureus with the clear zone diameter of 2.5 mm. The LC50 value of the biotransformed compound was 131.272 ppm, higher than curcumin’s LC50, which is 82.153 ppm. This value was obtained by probit analysis using SPSS (Statistical Product and Service Solutions) program.
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Judul: Potensi Antibakteri Kurkuminoid dan Nanokurkuminoid Temulawak (Curcuma xanthoriza) Secara In Silico dan In Vitro.
Abstrak: Kurkuminoid termasuk senyawa yang cepat dimetabolisme. Bentuk nanoemulsi dapat menjadi alternatif untuk mengatasi permasalahan tersebut. Antibakteri pada umumnya menghambat pembentukan dinding sel. Enzim MurA berperan penting dalam pembentukan dinding sel bakteri. Penelitian mengenai fungsi kurkuminoid sebagai antibakteri secara in silico serta potensi nanokurkuminoid sebagai antibakteri belum pernah dilakukan. Penelitian ini bertujuan menguji potensi kurkuminoid sebagai antibakteri melalui uji penghambatan enzim UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) secara penambatan molekuler serta mengukur aktivitas antibakteri dari nanokurkuminoid menggunakan uji difusi cakram. Senyawa kurkuminoid menunjukkan nilai energi bebas Gibs lebih kecil dibandingkan dengan ligan pembanding. Nanokurkuminoid memiliki nilai MIC 200 μg/mL untuk ekstrak kasar pada bakteri Escherichia coli serta 400 μg/mL untuk bakteri Bachillus subtilis. Zona bening nanokurkuminoid mendekati dengan senyawa ekstrak kasar dengan konsentrasi senyawa aktif yang kecil. Senyawa kurkuminoid mampu menunjukkan aktivitas antibakteri baik secara in silico maupun dalam bentuk nanokurkuminoid secara in vitro.
Keyword: antibakteri, diffusi cakram, docking, enzim MurA, nanokurkuminoid

Judul: Perbandingan Answer Set Programming dan Iterative Deepening Search dalam Menyelesaikan Game N-puzzle
Abstrak: N-puzzle is one of the known NP-complete problems in the field of puzzles and games. The purpose of N-puzzle is to arrange numbers from 1 to (n2-1) in an n x n grid, with one grid contains a blank square. The research aims to compare the use of Answer Set Programming (ASP), as one of the currently used formalism to express and solve hard computational problems, with the traditional Iterative Deepening Search (IDS) in solving the N-puzzle. An encoding of N-puzzle problem and solver was devised and executed using the DLV system, while IDS is implemented as an ad-hoc program solving the N-puzzle problem. The result of experiment shows that the ASP using DLV is more effective in finding solutions, because it requires no depth parameters to find solutions, while IDS does. On the other hand, the IDS implementation was more efficient in terms of execution time.
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