Judul: Penaeus Nanochitosan sebagai Biomaterial Medis untuk Penyembuhan Luka Bakar pada Tikus Sprague Dawley secara In Vivo
Abstrak: Luka bakar yang sulit untuk disembuhkan menjadi faktor risiko infeksi dan penyebab utama dilakukannya penanaman kulit serta tindakan amputasi. Modifikasi kitosan menjadi nanokitosan memiliki keunggulan yaitu ukuran partikel yang lebih kecil sehingga bersifat reaktif dan mempercepat penyembuhan luka. Penelitian ini bertujuan mendapatkan kitosan dan nanokitosan, karakteristik kitosan dan nanokitosan, serta menguji nanokitosan sebagai penyembuh luka bakar pada tikus. Penelitian eksperimental dilakukan secara in vivo, sebanyak 25 ekor tikus dibagi lima kelompok. Pembuatan nanokitosan dengan metode gelasi ionik. Kelompok kontrol negatif (kontrol tanpa perlakuan), kontrol positif (Bioplacenton®), nanokitosan 1000 ppm, 1500, dan 2000 ppm. Hasil pengamata n makroskopis dan mikroskopis menunjukan bahwa sediaan nanokitosan (C, D dan E) memiliki pengaruh terhadap persentase penyembuhan luka bakar pada hari ke- 18 sebesar (99,6% ; 98,7%; 93,8%). Kondisi luka dan persentase pengecilan luasan luka lebih baik dibandingkan dengan kontrol positif dan kontrol negatif. Sediaan nanokitosan (C, D, dan E) sudah masuk tahap maturasi awal pada hari ke-7. Kata kunci : Kitosan, Luka bakar thermal, Nanokitosan
Keyword: Kitosan, Luka bakar thermal

Judul: Test the Effectiveness of the Combination Gel of Turmeric Nanoparticles and Sea Cucumber: Histopathological Study of Skin Incision Wound Healing
Abstrak: Luka adalah terputusnya kontinuitas jaringan kulit. Luka akan menimbulkan rasa tidak nyaman pada penderitanya. Penelitian ini adalah bagian dari uji pendahuluan untuk mengevaluasi aplikasi kombinasi gel nanopartikel ekstrak kunyit dan jeli gamat untuk proses penyembuhan luka sayat pada tikus Sprague-Dawley berdasarkan pengamatan mikroskopis. Kulit 10 ekor tikus jantan disayat pada bagian punggung. Perlakuan dibagi menjadi lima kelompok yaitu, kontrol negatif (P0), gel kombinasi 0,5% (P1), 1%(P2), 2% (P3), dan kontrol positif (P4). Pengobatan dilakukan setiap hari selama seminggu. Secara histopatologi, spesimen diwarnai dengan Hematoksilin-Eosin untuk mengamati struktur kulit dan AE1/AE3 untuk melihat ekspresi sitokeratin. Pengamatan dievaluasi pada hari ke-2 dan ke-7 pasca perlukaan. Parameter histopatologi yang diamati adalah keropeng, epitelisasi, dan neovaskularisasi. Data disajikan secara deskriptif melalui foto. Hasil pengobatan luka gel kombinasi hari ke-2 dan ke-7 menunjukkan luka mengalami penyembuhan. Penyembuhan pada luka yang diobati dengan gel kombinasi konsentrasi 0,5% paling baik dibandingkan pengobatan konsentrasi lainnya., Wound is a break in the continuity of skin tissue. The wound will cause discomfort in the sufferer. This study is part of a preliminary test to evaluate the application of a combination of turmeric extract nanoparticle and jelly gamat for the wound healing process in Sprague-Dawley rats based on microscopic observations. The skins of 10 male rats were cut 3 cm left lateral area. The treatments were divided into five groups namely, negative control (P0), 0,5% gel combination (P1), 1% (P2), 2% (P3), and positive control (P4). Treatment was given everyday in a week. Histopathologically, the specimens were stained with Hematoxylin-Eosin to observe the skin structure and AE1 / AE3 to observe cytokeratin expression. The observations were evaluated on the second and seventh days post-injury. The histopathological parameters observed were scab, epithelial formation, and neovascularization. Data were presented descriptively through light microscope. The results of wound treatment on second and seventh day showed that the wound had a healing process. Healing of wounds treated with a 0.5% combination gel is the best among other consentration of treatment.
Keyword: jelly gamat, microscopic, turmeric, wound healing

Judul: Exchange Market Pressure and Central Bank Intervention for Three ASEAN Countries
Abstrak: Two of the exchange rate systems which are adopted by many countries are the floating and the fixed exchange rate system. Both the exchange rate systems have different characteristics. Countries that implement fixed exchange rates system tend to set their domestic currency exchange rate at a certain point. On the contrary, countries which implement floating exchange rate system tend to let their domestic currency exchange rate to move flexibly and thus their value will always change according to the demand and supply of the currency in the foreign exchange market. Countries which implement floating exchange rate system are facing the risk of fluctuation in the exchange rate of their domestic currency against foreign currencies. The currency exchange rate fluctuation may be caused by economic problems such as a financial crisis. A country can also be potentially affected by other countries’ earlier financial crisis. This effect could potentially happen if these countries are in the same region, such as ASEAN. The 1997 ASEAN economic crisis was an example of a country’s financial crisis could affect other countries. At that time, some countries such as Indonesia, Malaysia and Thailand had to change their currency exchange rate system from the fixed exchange rate system to the floating exchange rate system due to the high costs which has to be incurred if they were to enforce the fixed exchange rate system. During 2002 until 2012, the domestic exchange rate of Indonesia, Malaysia and Thailand against the U.S. dollar had tended to fluctuate. If the domestic currency exchange rate fluctuated excessively then the central bank would intervene to stabilize the exchange rate in the foreign exchange market. The pressure on domestic currency exchange rate pressures has forced the central bank to intervene. The amount of those pressures can be analyzed by calculating the Exchange Market Pressure (EMP) index. Apart from that, the time when interventions are done by the central bank can be known based on EMP by calculating the Exchange Market Intervention (EMI) index. The purposes of this study were to determine the level of international pressure on the currency exchange market and monetary authorities intervene in three ASEAN countries, as well as to determine the effect of the monetary authorities intervene on the exchange rate of the domestic currency against the U.S. dollar in those three ASEAN countries. Based on the EMP index calculation results which are obtained during 2002 to 2012 period, the exchange rate of Indonesia, Malaysia and Thailand’s domestic currency had always fluctuated and the results of the EMP index indicated that each country were under diverse level of currency exchange rate appreciation and depreciation pressures. Thailand was the country with the highest currency exchange rate pressure compared to Indonesia and Malaysia. The results on the intervention index calculation showed that Indonesia, Malaysia and Thailand have intervention index between zero and one and more than one. We can also see from the intervention index that Indonesia and Thailand implement the controlled floating currency exchange rate instead of the freely floating one. Based on the calculation of the currency exchange rate by comparing
Keyword: exchange rate, exchange market pressure, intervention