Judul: Sitotoksisitas ekstrak kulit kayu Pinus merkusii Jungh. et de Vriese terhadap sel kanker serviks HeLa
Abstrak: Kanker serviks merupakan kanker yang paling banyak menyebabkan kematian pada wanita di Indonesia. Salah satu upaya pengobatan kanker dapat dilakukan dengan memanfaatkan senyawa dari bahan alam. Beberapa tanaman mempunyai potensi sebagai antikanker, salah satunya adalah kulit kayu Pinus merkusii. Tujuan dari penelitian ini adalah menguji aktivitas sitotoksik ekstrak kulit kayu Pinus merkusii terhadap sel HeLa dengan uji microculture tetrazolium technique (MTT). Penelitian ini juga menguji kandungan fitokimia dan penapisan awal sitotoksisitas dengan Artemia salina. Rendemen tertinggi diperoleh dari ekstrak etanol 70% sebesar 6.30%. Pinus merkusii mengandung flavonoid, triterpenoid, saponin, dan tanin. Hasil uji sitotoksisitas menggunakan A. salina menunjukkan bahwa ekstrak kulit kayu P. merkusii memiliki aktivitas dan potensi antikanker karena nilai LC50 < 1000 μg/mL. Ekstrak etanol 70% kulit kayu P. merkusii memiliki aktivitas sitotoksik paling tinggi terhadap sel HeLa dengan nilai IC50 sebesar 266.01 μg/mL daripada ekstrak metanol, air, dan aseton dengan IC50 berturut-turut sebesar 408.13 μg/mL, 433.51 μg/mL, dan 880.24 μg/mL.
Keyword: Bogor Agricultural University, Institut Pertanian Bogor, IPB, Cervical cancer, Cytotoxicity, HeLa cells, Pinus merkusii

Judul: Sitotoksisitas Ekstrak Kulit Kayu Pinus merkusii Jungh. et de Vriese terhadap Sel Kanker Serviks HeLa
Abstrak: Cervical cancer is the most common death cause of cancer in Indonesian women. One of the efforts of cancer treatment is the utilization of natural materials compounds. Some plants have potential as anticancer, one of them is bark of Pinus merkusii. The purpose of this study was to determine the cytotoxic activity of Pinus merkusii bark extract against HeLa cells by microculture tetrazolium technique (MTT) assay. The study also tested the phytochemical content and the initial screening of cytotoxicity with Artemia salina. The Highest yield of 70% ethanol P. merkusii bark extract was 6.30%. Pinus merkusii contains flavonoids, triterpenoids, saponins and tannins. The results of cytotoxicity assay using A. salina showed that the Pinus merkusii bark extract has activity and potential as anticancer indicated by its LC50 values < 1000 μg/mL. The 70% ethanol extract of P. merkusii bark has highest cytotoxic activity against HeLa cells with IC50 value of 266.01 μg/mL which was higher than methanol, water, and aceton extract with IC50 values for respectively 408.13 μg/mL, 433.51 μg/mL, dan 880.24 μg/mL.
Keyword: 

Judul: Hamiltonian formulation for linear waves motion in two layers fluid
Abstrak: The surface wave could be considered as a wave that separates two fluids, namely water and air. Based on this assumption, it is introduced the interfacial wave, a wave between two layers of fluid with different density. The formulation of interfacial waves motion begins with deriving the base equation of irrotational ideal fluid. Furthermore, according to irrotational fluid assumption, the base equation can be stated in velocity potential. In this derivation, the fluids domain is assumed to be restricted by rigid lid boundary conditions, both at the upper and lower limit. Therefore, the interfacial waves motion can be explained in a hamiltonian formulation. In the hamiltonian formulation, total energy is defined as the sum of kinetic and potential energy. The hamiltonian system is obtained from reduction of kinetic energy by using the Dirichlet Neumann Operator. The resulted kinetic energy equation is nonlinear. Therefore, this form is linearized by first part of the Taylor expansion. This linearization gives a dispersion relation of linear wave. Based on this dispersion relation, the phase speed of the linear wave depends on the density ratio of the two layers fluid.
Keyword: