Judul: Social Media and Early Marriage Among Rural Adolescents (Case: Desa Pamijahan, Kecamatan Pamijahan, Kabupaten Bogor)
Abstrak: Pandangan bahwa pernikahan dini sebagai sesuatu hal yang wajar dan tidak perlu dipermasalahkan memberikan dampak terhadap meningkatnya pernikahan usia dini di pedesaan. Salah satu faktor lainnya yaitu seiring dengan perkembangan internet, remaja di pedesaan sudah terbiasa untuk menjalin pertemanan dan mencari informasi melalui media sosial. Penelitian ini bertujuan untuk menganalisis hubungan penggunaan media sosial dengan sikap remaja tentang pernikahan dini di Desa Pamijahan. Jumlah responden yang telah diteliti sebanyak 60 orang remaja dengan menggunakan pendekatan kuantitatif melalui metode survei yang memanfaatkan kuesioner dan didukung oleh data kualitatif dari hasil wawancara mendalam serta observasi. Hasil penelitian ini menunjukkan bahwa tidak terdapat hubungan nyata antara tingkat penggunaan media sosial dengan sikap remaja tentang pernikahan dini, tetapi setelah tingkat penggunaan media sosial diuraikan per aplikasi, ditemukan beberapa aplikasi media sosial yang berhubungan secara signifikan dengan sikap remaja tentang pernikahan dini. Kecenderungan remaja Desa Pamijahan untuk menikah dini disimpulkan termasuk dalam kategori sedang karena masih ada remaja yang ingin dan mau melakukan pernikahan dini, tetapi tingkat penggunaan media sosial masih belum menjadi salah satu faktor remaja melakukan pernikahan dini., The view that early marriage is something that is normal and does not need to be questioned has an impact on the increase in early marriage in rural areas. One other factor is that along with the development of the internet, youth in rural areas are used to making friends and seeking information through social media. This study aims to analyze the relationship between social media use and adolescent attitudes about early marriage in Pamijahan Village. The number of respondents who were studied was 60 teenagers using a quantitative approach through a survey method using a questionnaire and supported by qualitative data from the results of in-depth interviews and observations. The results of this study indicate that there is no significant relationship between the level of social media use and adolescent attitudes about early marriage, but after the level of social media use is described per application, several social media applications are found to be significantly related to adolescent attitudes about early marriage. It is concluded that the tendency of adolescents in Pamijahan Village to marry early is included in the moderate category because there are still teenagers who want and want to do early marriage, but the level of social media use is still not a factor for young people to marry early.
Keyword: early marriage, social media usage, teenager characteristics

Judul: Strengthening Community in Tackling Early Marriage in the Digital Era (Study of Communities in Sukabumi City)
Abstrak: Early marriage is a marriage that occurs when one or both have not met the ideal age to marry, which is under 21 years old for women and 25 years old for men. Entering the digital era, the use of information and communication technology is increasingly integrated with every area of human life including the way people interact to make a business, especially in young couples.The purpose of this study was to analyze the related factors that influence a person's early marriage and describe strengthening the community in tackling early marriage in the digital age. Data collection techniques through questionnaires are structured in google forms for quantitative data and in-depth interviews with informants for qualitative data. Correlation testing using Chi-Square is done to find relationships between variables. The results of this study show that there are behavioral changes caused by high access to the openness of territory and approval of early marriage that result in the younger age of one's first marriage. Meanwhile, there is no relationship between changes in dating behavior with family conditions. The role of the community through the Kampung KB program that integrates with digital reduces the risks posed by early marriage such as inviting discussions about good parenting, solving family problems that avoid divorce, Pernikahan dini merupakan pernikahan yang terjadi ketika salah satu atau keduanya belum memenuhi usia ideal untuk menikah yaitu dibawah 21 tahun untuk perempuan dan dibawah 25 tahun untuk laki-laki. Memasuki era digital pemanfaatan teknologi informasi dan komunikasi semakin diintegrasikan pada setiap bidang kehidupan manusia termasuk cara orang berinteraksi hingga membuat sebuah usaha khususnya pada pasangan muda. Tujuan dari penelitian ini untuk menganalisis hubungan perubahan perilaku kencan dengan usia menikah pertama serta menggambarkan penguatan komunitas dalam menanggulangi pernikahan dini pada era digital. Teknik pengumpulan data melalui kuesioner terstruktur dalam google form untuk data kuantitatif dan wawancara mendalam kepada informan untuk data kualitatif. Pengujian korelasi menggunakan Chi-Square dilakukan untuk menemukan hubungan antar variabel. Hasil penelitian ini menujukkan bahwa terdapat perubahan perilaku yang disebabkan oleh tingginya akses keterbukaan wilayah dan kesetujuan terhadap pernikahan dini yang berakibat pada semakin mudanya usia menikah pertama seseorang. Sementara, tidak terdapat hubungan pada perubahan perilaku kencan dengan kondisi keluarganya. Peran komunitas melalui program Kampung KB yang teintegrasi dengan digital mengurangi resiko yang ditimbulkan dari pernikahan dini seperti mengajak berdiskusi mengenai pola asuh anak yang baik, pemecahan permasalahan keluarga yang menghindari perceraian.
Keyword: community strengthening, digitalization, dating behaviour, early marriage

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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