Judul: Potensi bakau Rhizophora apiculata sebagai inhibitor tirosinade dan antioksidan
Abstrak: The purpose of this study was to screen the potency of crude extract, fractions from silica gel column chromatography, and fraction from preparative thin layer chromatography (TLC) of Rhizophora apiculata which has the best activity as tyrosinase inhibitors, and antioxidant. Stem, bark and roots of R. apiculata were extracted with n-hexane, ethylacetate and methanol. Each extracts were tested for tyrosinase inhibitors and antioxidant activities. Based on the tyrosinase inhibitors, methanol extracts of R. apiculata bark had the best potency as tyrosinase inhibitors (monophenolase: 78.79 μgmL-1; diphenolase: 1116.5 μgmL-1) and the best radical scavenging activity 1,1-diphenyl-picrylhidrazil (DPPH) and 2,2’- Azinobis(3-etilbenzatiazolin)-6-sulfonat acid (ABTS) with IC50: 3.81 μgmL-1 and 18.47 μgmL-1, respectively. Fractionation was performed on methanol extracts of R. apiculata bark using silica gel column chromatography and yielded 10 fractions (A to J). Fraction B from column chromatography had the best tyrosinase inhibitors with monophenolase (IC50: 1045.6 μgmL-1), diphenolase (IC50: 846.71 μgmL-1), and the best antioxidants activities with DPPH (IC50: 9.19 μgmL-1), ABTS (IC50: 7.73 μgmL-1). Fraction B was fractionated with preparative TLC resulted 9 fractions (B1 to B9). Fraction B1 had the best tyrosinase inhibitors with monophenolase (IC50: 1278 μgmL-1) and diphenolase (IC50: 1678.2 μgmL-1), dan the best antioxidants activity with DPPH (IC50: 5.75 μgmL-1), ABTS (IC50: 24.78 μgm/L). Fraction B1 further fractionated with preparative TLC resulted 2 fractions (B1.1 and B1.2). Fraction B1.1 had the best tyrosinase inhibitors with monophenolase (IC50: 1037.32 μgmL-1) and diphenolase (IC50: 1257.24 μgmL-1), and antioxidants activity with DPPH (IC50: 14.40 μgmL-1), ABTS (IC50: 40.67 μgmL-1). The result of phytochemical test and infrared spectroscopy on fraction B1.1 showed that the active compounds as tyrosinase inhibitors and antioxidant was an isoflavon compound.
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Judul: Sidik Jari Bakau (Rhizophora sp.) sebagai Bahan Baku Antioksidan dan Inhibitor Tirosinase
Abstrak: Rhizophora sp. is one species of mangrove which has many functions including cosmetic herbal, one of which is as inhibitor of tyrosinase enzyme to heal hyperpigmentation and melanosis in human skin. The aim of this study is to determine fingerprint of Rhizophora sp. from Lampung and Makassar to be utilized as control and stability of herbal plants. Selection of the best mobile phase is an important step in components separation. Chloroform was the best eluent selected which resulted 5 spots in Rf range of 0.04–0.74. Makassar’s R. apiculata bark extract was potential as tyrosinase inhibitor for monophenolase with 50% inhibition concentration (IC50) of 968.83 μg/mL, whereas extract having the best antioxidant activity was Makassar’s R. apiculata leaves extract with IC50 value of 5.09 μg/mL.
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Judul: Lansekap Sejarah: Cagar Budaya Condet, di DKI Jakarta
Abstrak: Kuliah Kerja Nyata (KKK) dilaksanakan dari tanggal 3 Pebruari 1986 sampai 3 April 1986 d i Kawasan Cagar Budaya Condet, Kecamatan Kramat Jati, Jakarta Timur. Program yang dilaksanakan, meliputi program mum dan khusus. Tujuan Program umum mencakup kepentingan tiga unsur yang terlibat, yaitu perguruan tinggi, mahasiswa dan masyarakat. Satu diantaranya adalah menghasilkan sarjana sebagai penerus pembangunan yang menghayati permasalahan yang kompleks, yang dihadapi masyarakat dalam pembangunan dan belajar menanggulangi permasalahan tersebut secara pragmatis dan inter disipliner.
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