Judul: Stabilitas nanopartikel ketoprofen tersalut gel kitosan-alginat
Abstrak: Stability test is a test to be done in pharmaceutical product development. Without stability test data, drug stability cannot be predicted during the usage. Previous nanocapsule preparation has been studied with a composition of 1.75% chitosan, 0.625% alginate, 4.5% tripolyphosphate, 0.8% ketoprofen, Tween 80 with various concentrations (1, 2, and 3%), and sonication in various times (15, 30, and 60 minutes). This study used an accelerated stability test at temperature (40 ± 2) °C and relative humidity (75 ± 5)% for 3 months. The tests included moisture content and ketoprofen content, which were performed by gravimetric method and by UV spectrophotometer at 257.5 nm, respectively. The result showed that moisture content fluctuated between 10 and 13%, whereas ketoprofen levels tended to decrease each week. The best formula was nanoparticle with 2% of Tween 80 and 30 minutes sonication time, which resulted moisture content and usage of 11.53% and 10.25 week, respectively.
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Judul: Perilaku Disolusi Mikrokapsul Ketoprofen Tersalut Gel Kitosan-Alginat Berdasarkan Ragam Konsentrasi Tween 80
Abstrak: Chitosan ability to form gel has been extensively studied and modified; natural hydrocoloid addition is just an example. Chitosan-alginate gel has a promising potential to be applied as a good coating material in drugs delivery system. In this study, chitosanalginate gel coated ketoprofen microcapsules were made using spray drying method. Tween 80 solution concentration used in the process was varied (1, 2, and 3% (v/v)). The resulting microcapsules particle sizes were ranging from 150 nm to 6 μm. The dissolution test results showed that the Tween 80 solution concentrations were affecting ketoprofen releasing rate for the microcapsule. Maximum ketoprofen release rates either in acidic or basic medium were observed at 2% Tween 80 concentration. The maximum released ketoprofen amounts in acidic and basic medium were 35.19 and 287.92 ppm, respectively. The releasing mechanism was determined by evaluating the releasing kinetic models. The ketoprofen releasing kinetic model, both in acidic and basic medium, was following the Hixson-Crowell kinetic model.
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Judul: Ekologi merak hijau jawa (Pavo muticus muticus) Linnaeus 1758 pada beberapa tipe habitat di Ujung Timur Penyebarannya Jawa Timur, Indonesia
Abstrak: Merak hijau jawa merupakan salah satu jenis burung yang dilindungi.di Indonesia berdasarkan SK Mentan No 66/Kpts/Um/2/1973 dan Peraturan Pemerintah Republik Indonesia No 7 tahun 1999. Menurut ICBP (The International Council for Bird Preservation) merak hijau sebagai jenis burung yang tergolong terancam secara keseluruhan (globally threatened) baik populasi maupun habitatnya, sedangkan CITES mencantumkan merak hijau ke dalam Appendix II, merak hijau dari alam tidak bisa langsung diperdagangkan dan BirdLife International (2007) memasukkan golongan burung yang endangered. Tekanan terhadap populasi dan habitat merak hijau jawa sangat besar, sehingga kondisi populasinya menurun pada setiap penyebaran lokalnya, habitatnya terfragmentasi bahkan terisolasi. Tekanan terhadap populasi terutama karena perburuan liar. Namun demikian fakta menunjukan bahwa merak hijau jawa masih ada (exist), hal ini memberikan gambaran bahwa burung ini tentunya memiliki strategi ekologi tertentu untuk tetap bertahan hidup di alam pada berbagai tipe habitat.
Keyword: Pavo muticus muticus, Call count transect method, Pavo cristatus, Pavo muticus, Pavo muticus spicifer, Pavo muticus imperator, Pavo muticus muticus, Javan Green Peafowl, East Java