Judul: Landscape Designing a Neighborhood Park in  Flats Paspampres, IKN Nusantara, East Kalimantan
Abstrak: Sepaku, Kalimantan Timur ditetapkan menjadi IKN karena aksesibilitas lokasi yang tinggi, berada di sekitar dua kota besar, struktur kependudukan heterogen, potensi konflik rendah, pertahanan didukung oleh Tri Matra Darat, Laut, Udara, dan infrastruktur utama lengkap. Pembangunan yang pesat akan mendorong peningkatan kebutuhan hunian vertikal yang cerdas serta ruang terbuka hijau untuk mengurangi emisi gas rumah kaca bagi para Aparatur Sipil Negara serta masyarakat umum. Desain lanskap ini memanfaatkan lahan terbuka sebagai taman lingkungan di rusun Paspampres. Taman lingkungan adalah salah satu ruang terbuka hijau yang berperan penting sebagai media beraktivitas di ruang terbuka bagi penduduk, selain memberi fungsi sosial, ekologis dan fungsi penting lainnya. Tujuan dari penelitian ini yaitu mengidentifikasi dan menganalisis lanskap Rusun Paspampres serta menghasilkan desain lanskap taman lingkungan berbasis konsep biomimicry pada rusun Paspampres. Metode yang digunakan dalam penelitian ini yaitu metode deskriptif mengacu pada tiga pendekatan yaitu fisik-biofisik, sosial, dan legal. Data diambil melalui survei dan studi literatur. Tahapan penelitian dilakukan mulai dari Project Acceptance, Research/Analysis, Design, and Constructional Drawing. Desain menggunakan pola desain dari transformasi bentuk pohon hayat pada logo IKN sehingga menghasilkan 4 ruang yaitu ruang penerimaan, rekreasi, pendukung dan religi. Topografi tapak yang menyebabkan genangan air dimanfaatkan sebagai embung untuk konservasi air dan pengendali iklim mikro. Desain lanskap taman lingkungan diharapkan menjadi bahan acuan bagi pemerintah dan pengelola dalam pengembangan ruang terbuka hijau., Sepaku, East Kalimantan has been designated as the new capital city (IKN) due to its high accessibility, proximity to two major cities, heterogeneous population structure, low potential for conflict, and defense supported by the Tri Matra of Land, Sea, and Air forces. Additionally, the area is equipped with complete main infrastructure. Rapid development in this area drives the need for smart vertical housing and green open spaces to reduce greenhouse gas emissions for civil servants and the general public. This landscape design utilizes open land as an environmental park in the Paspampres apartments. Environmental parks are one of the green open spaces that play an important role as a medium for outdoor activities for residents. Besides that, they also provide social, ecological, and other important functions. The aim of this research is to identify and analyze the landscape of the Paspampres apartments and produce an environmental park landscape design based on the concept of biomimicry in the Paspampres apartments.The method used in this research is a descriptive method referring to three approaches: physical-biophysical, social, and legal. Data was collected through surveys and literature studies. The research stages were carried out from Project Acceptance, Research/Analysis, Design, and Construction Drawing. The design uses a pattern from the transformation of the tree of life shape on the IKN logo, resulting in four spaces: reception, recreation, support, and religious spaces. The site's topography, which causes water pooling, is utilized as a reservoir for water conservation and microclimate control. The environmental park landscape design is expected to serve as a reference for the government and managers in developing green open spaces.
Keyword: Landscape Design, Flats, Green Open Spaces, IKN Nusantara, Neighborhood Park

Judul: Landscape Design of Islamic Center, Kuningan Regency based on Eco-design Toward to Green Infrastructure
Abstrak: Kuningan Islamic Center merupakan ruang terbuka hijau di Kabupaten Kuningan dengan fasilitas yang tidak optimal dalam mengakomodasi kegiatan pengunjung, terletak di kawasan yang direncanakan oleh pemerintah Kabupaten Kuningan sebagai pusat pemerintahan. Dengan adanya pengembangan kawasan maka diprediksi akan terjadi perubahan area hijau menjadi area terbangun yang dapat mengganggu kestabilan lingkungan, sehingga diperlukan upaya penataan berbasis eco-design. Tujuan penelitian ini yaitu menganalisis karakter tapak dan pengunjung serta potensi tapak yang dapat mendukung kegiatan pengunjung, dan merancang desain lanskap Kuningan Islamic Center berbasis eco-design. Penelitian menggunakan metode deskriptif kualitatif melalui studi literatur serta pengamatan lapang, dengan tahap desain mengacu pada proses perancangan Gold (1980) yang terdiri dari inventarisasi, analisis, sintesis, dan perancangan. Penelitian ini menghasilkan desain Kuningan Islamic Center berbasis eco-design yang dipadukan dengan konsep taman Islam, konsep eco-design berfokus pada upaya konservasi air, tanah, dan kualitas udara serta habitat satwa dengan mengaplikasikan rainwater harvesting berupa bio-retention pond, meminimalkan runoff air hujan melalui bioswale dan rain garden, serta menyediakan habitat satwa khususnya burung. Penghematan energi melalui pemanfaatkan energi matahari, penerapan green building serta pemanfaatan air hujan guna irigasi tapak. Penggunaan material ramah lingkungan dengan memanfaatkan material lokal dan eksisting, serta material penutup tanah yang dapat menginfiltrasi air. Revitalisasi tapak menjadi taman yang akomodatif dengan menerapkan desain sesuai dengan preferensi pengunjung tapak., Kuningan Islamic Center (KIC) is an open space in Kuningan that does not have optimal facilities to accommodate visitors, located in the area planned by the Kuningan's Government as the new regional government center. With the development of the area, it is predicted that there will be a change from a green area into a built area that can disrupt environmental stability, so the eco-design arrangement is needed. The purpose of this study is to analyze the character of site visitors, the potenctials of the site, and design KIC based on eco-design. This research used a qualitative descriptive method through literature study and field observation, with the design phase referring to Gold (1980) which consists of inventory, analysis, synthesis, and design. This results is the landscape design of KIC based on eco-design, that focuses on efforts to conserve water, soil, air quality, and animal habitat by applying rainwater harvesting through bio-retention pond, minimizing rainwater runoff through bioswales and rain gardens, and providing habitat for animals, especially birds. Energy savings is implemented by utilizing solar energy, implementing a green building, and utilizing rainwater for site irrigation. The materials used are environmentally-friendly materials, local materials, ground cover materials that can infiltrate water, and utilizing existing materials. The site is revitalize into an accommodative park by implementing designs based on the preferences of the site visitors.
Keyword: Ekologi, Fasilitas publik, Konservasi, Lanskap berkelanjutan, Ruang Terbuka Hijau

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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