Judul: Sistem penunjang keputusan pendirian industri kompos (studi kasus di TPA Galuga, Bogor)
Abstrak: Waste becomes important environmental issue for urban people, since the waste volume is increasing due to the population growth. Currently, traditional market waste only processed in conventional way by collecting it from local waste disposal and send it to the Final Waste Disposal (Tempat Pembuangan Akhir-TPA)
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Judul: Perencanaan pendirian industri kompos berbahan baku sampah kota : Studi kasus di Kotamadya Bogor
Abstrak: Perkembangan kota Bogor mendorong pertumbuhan penduduk dan perkembangan industri serta pembangunan fasilitas pendukung kota. Dampak perkembangan tersebut adalah semakin besarnya jumlah limbah yang dihasilkan, sedangkan daya dukung lingkungan semakin berkurang akibat buangan limbah tersebut. Kota Bogor menghasilkan sampah sekitar 1.965 m² setiap hari dengan komposisi 3 sampah organik 81% dari total sampah, dan berarti terdapat sekitar 1.593 m² sampah yang potensial sebagai bahan baku kompos. Berdasarkan data Dinas Kebersihan dan Pertamanan Kotamadya Bogor 1997, jumlah yang dapat terangkut sebesar 1.310 m² atau baru dapat ditangani 82% dari total sampah organik (Dinas Kebersihan dan Pertamanan Kotamadya Bogor, 1998). Berdasarkan ketersediaan sampah organik yang cukup, maka diperlukan kajian perencanaan pendirian industri kompos berbahan baku sampah kota di Kotamadya Bogor.. Hasil kajian ini diharapkan dapat memberikan gambaran tentang kemungkinan pendirian industri kompos tersebut. Ruang lingkup kajian adalah mempelajari pra-kelayakan industri kompos melalui kajian pasar dan pemasaran, teknis teknologis, manajemen operasi proyek dan finansial sebagai alternatif pengelolaan sampah pasar di Kotamadya Bogor...
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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