Judul: Metode cepat kuantifikasi terfenadin dalam sediaan farmasi secara spektrofotometri derivatif ultraviolet
Abstrak: Terfenadin ialah antihistamin dengan efektivitas tinggi yang telah digunakan secara luas untuk mengatasi alergi. Metode cepat dan dapat dipercaya untuk menentukan terfenadin sangat dibutuhkan dalam mendukung kontrol mutu obat. Metode spektrofotometri derivatif ultraviolet (UV) turunan pertama telah dikembangkan untuk menentukan terfenadin dalam sediaan farmasi dan dibandingkan dengan kromatografi cair kinerja tinggi (KCKT). Kuantifikasi terfenadin secara spektrofotometri derivatif UV (SDUV) dilakukan berdasarkan pengukuran amplitudo puncak ke garis dasar pada panjang gelombang 225.2 nm. Hasil analisis terfenadin secara SDUV pada Terfin® dan Rhinofed® menunjukkan kadar berturut-turut sebesar 60.14 mg/tablet dan 39.90 mg/tablet. Hasil analisis terfenadin secara KCKT pada Terfin® dan Rhinofed® menunjukkan kadar berturut-turut 70.79 mg/tablet dan 47.49 mg/tablet. Analisis secara statistik dengan menggunakan uji t-student dan F menunjukkan perbedaan yang nyata pada tingkat kepercayaan 95% di antara hasil analisis kedua metode. Uji linearitas pada metode SDUV menghasilkan koefisien korelasi (r) sebesar 0.9994 pada kisaran 2-10 ppm. Nilai simpangan baku relatif adalah 4.79% untuk tablet Terfin® dan 7.94% untuk tablet Rhinofed®. Nilai perolehan kembali berdasarkan metode penambahan standar adalah 81.30-110.30%, limit deteksi 1.31 ppm, dan limit kuantitasi 3.98 ppm.
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Judul: Pengembangan Metode Spektrofotometri UV-Vis untuk Penetapan Kadar Antibiotik Sefadroksil
Abstrak: Cefadroxil antibiotic is produced by Cephalosporium acremonium fungi and has been utilized widely. In the research, determination of cefadroxil in drug capsule by using ultraviolet-visible (UV-Vis) spectrophotometer was developed. This method is faster, easier, cheaper, and was proven to give results which were not different with the high performance liquid chromatograpy method which is used as the reference method in the Unites States Pharmacopeia for 30 minutes of hydrolysis time. The maximum wavelength was 355.5 nm in aquadest and 351.6 nm in phosphate buffer pH 5. Validation of the UV-Vis spectrophotometric method resulted accuration, precision, linearity, detection limit and quantitation limit complied with International Conference on Harmonization regulations. Overall, aquadest gave better validation results as solven than phosphate buffer pH 5.
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Judul: Local Capitalism of Bajonese (Case Study of Mola Bajonese and Mantigola Bajonese, Wakatobi Regency, South-East Sulawesi Province)
Abstrak: The economic and social transformation of Bajonese indicate that local communities are able to do social mobility by mean of business expansion in the direction of capitalism way of production. Social and economic transformation by Bajonese at the present is also refers to the changes in rural society based on monetary and the capitalist market mechanism. Mola is unique community which has transformated towards capitalism. In contrast, Mantigola tend to be persistent therefore based on the research problem, the purposes of this study are : (1) to understand how is the historical development of local community with the formation of local capitalism in Mola and Mantigola; (2) To understand and analyze the differences of cultural values orientation in Bajo, where Mola is more likely to be local capitalism actor, while Mantigola still maintaining the traditional lifestyle.
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