Judul: In-Silico Testing of Active Compounds from Jasmine (Jasminum sambac) Leaves as Estrogen Antagonists against Estrogen Alpha Receptors
Abstrak: Daun melati memiliki aktivitas antikanker pada payudara yang telah diketahui menghambat pertumbuhan sel kanker MCF-7. Sel kanker ini mengekspresikan reseptor estrogen α yang penting pada kanker payudara. Oleh karena itu, penelitian ini bertujuan untuk menganalisis senyawa aktif pada daun melati yang menunjukkan aktivitas antikanker pada payudara khususnya terhadap reseptor estrogen α secara in-silico. Hasil penelitian menunjukkan bahwa terdapat senyawa potensial sebagai antagonis reseptor estrogen α pada daun melati yang memodulasi beberapa gen yang memiliki kemampuan untuk meregulasi kelangsungan hidup sel. Gen yang termodulasi tidak secara spesifik hanya mempengaruhi sel kanker payudara positif reseptor estrogen α., Jasmine leaves have been known to possess anti-breast cancer activity by inhibiting the growth of MCF-7 cancer cells. This cancer cell expressed the important estrogen receptor α in breast cancer. Therefore, this study aimed to analyze the active compounds in jasmine leaves that exhibit anticancer activity in breast cancer, particularly against the estrogen receptor α by in-silico approach. The results indicate the presence of potential compounds as estrogen receptor α antagonists in jasmine leaves, which can modulate several genes capable of regulating cell survival. The modulated genes however do not specifically target only breast cancer cells with positive estrogen receptor α.
Keyword: jasmine leaves, breast cancer, estrogen receptor

Judul: Identification of Active Compounds in Endophytic Fungi Isolated From Soursop Leaf and Its Potential as Selective Estrogen Receptor Modulators
Abstrak: Kapang endofit daun sirsak memiliki aktivitas antikanker payudara dengan menghambat pertumbuhan sel kanker MCF-7. Sel ini mengekspresikan reseptor estrogen khususnya reseptor estrogen α. Penelitian ini bertujuan mengidentifikasi komponen senyawa aktif kapang endofit daun sirsak dan menentukan potensinya sebagai antikanker payudara melalui penghambatan reseptor estrogen α. Metode penelitian meliputi ekstraksi kapang endofit, identifikasi senyawa aktif dengan LC-MS/MS, dan studi in silico menggunakan reseptor estrogen α. Terdapat 44 senyawa yang berhasil teridentifikasi dengan waktu retensi yang beragam dan sebanyak 15 senyawa berpotensi sebagai antikanker payudara karena kemampuannya dalam menghambat pertumbuhan dan memicu terjadinya apoptosis pada sel kanker. Studi in silico menunjukkan senyawa 3-[(4-hydroxyphenyl)methyl]-octahydropyrrolo[1,2-a]pyrazine-1,4-dione memiliki efek inhibisi terbaik dengan nilai ∆G sebesar -8.3 kkal/mol. Simpulan penelitian ini adanya kemampuan dari ekstrak kapang endofit daun sirsak dalam menghambat reseptor estrogen α, Endophytic fungi isolated from soursop leaves has anticancer activity due to its ability to inhibit the growth of MCF-7 cancer cells. This cell express estrogen receptor, especially estrogen receptor α. This study aimed to identify the active compound in endophytic fungi isolated from soursop leaf and determine the potential as an anticancer of breast cancer through estrogen receptor α inhibition. The method of the research included endophytic fungi extraction, identification of active compound using LC-MS/MS, and in silico study used estrogen receptor α. There are 44 active compounds that are successfully identified with various retention times and 15 compounds has potential as anticancer due to their ability to inhibit the growth and trigger apoptosis in cancer cells. In silico study showed that 3-[(4-hydroxyphenyl)methyl]-octahydropyrrolo[1,2-a]pyrazine-1,4-dione has the best inhibition with ∆G values is -8.3 kcal/mol . The conclusion of this study is the ability of the extract of endophytic fungi isolated from soursop leaf to inhibit estrogen receptors α.
Keyword: breast cancer, endophytic fungi, estrogen receptor, soursop leaves

Judul: Manajemen Pemeliharaan Kuda (Equus caballus) Untuk Upacara Kenegaraan Dan Sarana Kesenjataan Di Detasemen Kavaleri Berkuda (DenKavkud) TNI-AD Parongpong
Abstrak: Cavalry Horse Detachement (Denkavkud) Indonesian National Army-Cavalary Parongpong is one of the Indonesian military units that utilize the horse and train it as a means of purpose of formal state ceremony and armed forces. Skills possessed by the horse cavalry was the result of care management and specialized training provided by the trainer. Aspects of care management are breeding, feeding, and management. Horses that are kept in the Denkavkud, Parongpong are stallions, mares, foals, and military horses. Total populations of horses at Denkavkud are 183 horses. Besides commited horse training (remonte), Denkavkud also did breeding program to produce horses that can be trained and used as a military horse. There are some issues contained in Denkavkud, such as some of the nutrients needed by the horses not being met from feed given. One of these is crude protein and lysine. Lactation mares was crude protein and lysine deficiency. The number of death in 2010 is higher than previous years. Based on the number of horses that died from January until June 2010 is 11 horses. The average mortality was caused by colic. Colic is caused by excessive eating, excessive drinking during hot, moldy food, and even by investment roundworms. Animal welfare in Denkavkud can be enhanced by improvement of feed given and improving the health of livestock through improved sanitation.
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