Judul: Enkapsulasi Ibuprofen Dengan Natrium Alginat-Pektin Menggunakan Metode Gelasi Ionik
Abstrak: Ibuprofen merupakan obat anti inflamasi non-steroid yang memiliki waktu paruh pendek dan dapat mengiritasi lambung. Enkaspulasi adalah salah satu cara yang dapat digunakan untuk memperkecil risiko tersebut. Dalam penelitian ini dipelajari enkapsulasi ibuprofen menggunakan natrium-alginat pektin menggunakan metode gelasi ionik. Komposisi natrium alginat-pektin dan konsentrasi CaCl2 digunakan sebagai variabel utama yang ingin dievaluasi pengaruhnya pada efisiensi enkapsulasi dan profil disolusi. Rentang efisiensi enkapsulasi yang diperoleh antara 71% dan 90%. Efisiensi enkapsulasi tertinggi diperoleh pada komposisi natrium alginat-pektin 2:1 (% b/v) pada konsentrasi CaCl2 10%. Kapsul yang dihasilkan memiliki bentuk yang semakin mendekati bulat dengan berkurangnya jumlah pektin. Pola pelepasan ibuprofen pada formula A1, A2, dan C1 menunjukkan pola pelepasan yang bertahap.
Keyword: enkapsulasi, gelasi ionik, ibuprofen, natrium alginat, pektin

Judul: Enkapsulasi ibuprofen dengan penyalut alginat-kitosan
Abstrak: Ibuprofen merupakan obat antiradang yang memiliki waktu paruh eliminasi singkat dan dapat menimbulkan iritasi lambung. Enkapsulasi senyawa dalam ukuran kecil dapat digunakan untuk meminimalkan kekurangannya tersebut. Dalam penelitian ini dipelajari enkapsulasi ibuprofen dengan sistem penyalutan alginat-kitosan. Enkapsulasi dilakukan dengan ragam jumlah ibuprofen dan konsentrasi kitosan (0.1, 0.3, dan 0.5% (b/v)). Parameter enkapsulasi yang diamati adalah morfologi kapsul, massa kapsul yang diperoleh, dan efisiensi enkapsulasi. Kapsul yang diperoleh memiliki diameter 1-2 mm. Kenaikan jumlah ibuprofen dan konsentrasi kitosan berpengaruh pada massa kapsul yang diperoleh, tetapi tidak berpengaruh pada efisiensi enkapsulasi (a = 0.05). Massa total kapsul tertinggi diperoleh saat nisbah alginat-ibuprofen 1:1.5 dengan konsentrasi kitosan 0.3% (b/v). Enkapsulasi ibuprofen dengan penyalut alginat-kitosan memperlihat-kan rerata efisiensi enkapsulasi (>86%) yang lebih tinggi dibandingkan dengan temuan lain yang menggunakan gelatin (74.00-84.80%).
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Judul: Thermal Characteristics and Dynamics of Tropical Cyclone over Western North Pacific Ocean: A Case Study of Typhoon Songda (Chedeng) 2011
Abstrak: The frequent occasion of Tropical Cyclone (TC) over Western North Pacific (WNP) Ocean lies from 10˚N to 26˚N and 121˚E to 170˚E. Sources of TC development come from warm ocean temperature where latent heat is released during condensation processes and subsequently concentrated in the boundary layer. Relative humidity at 850-700 hPa is responsible to produce the most intense storm. Meanwhile, weak vertical wind shear between 850-200 hPa is one of the dynamical factors that lead to the development of TC. Pressure level of 850-200 hPa is chosen to minimize the thermodynamic effect in the lower troposphere. Typhoon Songda (Chedeng in the Philippines) or TSC lasted from May 18th to 30th, 2011 and strengthened into powerful Super Typhoon stage between May 24th and 27th. Long curving track and the exhibition of all sequences of TC life cycle, TSC is then considered as an ideal case of TC. The objective of the study with case of TSC is to investigate the role of thermal characteristics and dynamics on TC intensity. The research is carried out by using Advanced Research of Weather Research and Forecasting model (WRF ARW model) version 3.3. Two domains are employed in the model. The first domain situate from 02˚N to 40˚N and 118˚E to 149˚E and cover spatial resolution () of 33.1 km. The second domain situate from 09˚N to 27˚N and 119˚E to 132˚E with of 11 km. Timestep of the model () is 120 seconds. The model is supported by the following physical parameterization, i.e., Yonsei University Scheme (YSU) in the boundary layer, Kain-Fritsch scheme (KF) in the cumulus, and WRF Single-Moment 3-class scheme in the microphysics. Initial meteorological condition prior to the formation of the cyclone is generated using WRF ARW standard-release model. Sensitivity of the model output is obtained from a selected single-parameter change scenarios, namely, 10 % to 20 % decrease and increase of wind shear initial data at 850-200 hPa, and by 10 % to 20 % decrease of relative humidity initial data at 850-700 hPa. The result showed that the negative correlations between wind shear and intensity are found in wind shear scenarios. Wind shears of 10 ms-1 which lead to strengthening of the wind intensity in the early period of Typhoon development are found in wind shear scenarios. The effect of wind shear changes on wind intensity is statistically significant in the 20 % wind shear scenarios. During mature stage, weak wind intensity occurred when wind shear increase as given in the WRF standard-release and the 20 % decreasing scenario. Different situation is found in the 20 % increasing scenario where wind shear tend to weak and lead to strong wind intensity at this stage. Meanwhile, the reduction of moisture supply at 850-700 hPa resulting from 20 % decreasing relative humidity play a major role in the weakening of wind intensity and reduces mechanical energy of the cycle process as much as 300 J kg-1.
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