Judul: Potential Compounds in Small Leaf Mahogany Seeds  (Swietenia mahogany) as Breast Anticancer with Molecular Docking Method
Abstrak: Di Indonesia, kanker payudara menempati peringkat pertama kasus kanker dengan penderita wanita terbanyak. Tamoxifen, Onapriston, dan Lapatinib, merupakan obat komersial antikanker payudara yang menimbulkan efek samping jika dikonsumsi dalam jangka panjang. Obat baru dari senyawa potensial bahan alam diperlukan sebagai alternatif, dapat dikembangkan secara komputasi dengan metode penambatan molekuler. Biji mahoni berdaun kecil (Swietenia mahagoni) dilaporkan berpotensi sebagai obat antikanker tersebut. Penelitian ini bertujuan memprediksi senyawa dalam biji mahoni berdaun kecil dan potensinya sebagai antikanker payudara dengan metode penambatan molekuler. dst ..., In Indonesia, breast cancer ranks first in cancer cases with the most female sufferers. Tamoxifen, Onapriston, and Lapatinib are commercial anticancer drugs that cause side effects if taken in the long term. New drugs from potential natural compounds are needed as alternatives and can be developed computationally with molecular docking methods. Small leaf mahogany seeds (Swietenia mahogany) are reported to have potential as an anticancer drug. This study aims to predict the compounds in small leaf mahogany seeds and their potential as anticancer breasts by molecular docking method. A total of 100 test ligands were docked to the estrogen receptor alpha (ERα), progesterone receptor (PR), and epidermal growth factor receptor (EGFR). Based on the results of molecular docking and the value of binding site similarity, the compounds 3,5,7,3',4',5'-hexahydroxyflavanone, isocorydine, 7-deacytoxy-7-oxogedunine, and stigmasterol, have potential as PR inhibitors. The results of pharmacokinetic and toxicity analysis showed that stigmasterol has the potential to be used as an oral drug and is not toxic.
Keyword: breast cancer, molecular docking, oral drug, Swietenia mahogany

Judul: Bioaktivitas Biji Mahoni Berdaun Lebar (Swietenia macrophylla) sebagai Antikanker
Abstrak: There are three species of mahogany in Indonesia, namely small-leaf mahogany (Swietenia mahogany), broad-leaf mahogany (Swietenia macrophylla), and Swietenia sp. This study aimed to study the toxicity of bioactive compounds in fractions of ethyl acetate extract from broad-leaf mahogany seeds, which is potencial as anticancer, by using brine shrimp lethality test. The seeds were ground into powder and air-dried. The powder was then soxhletized with nhexane. The residue was macerated in 96% ethanol. The ethanol extract was evaporated and then extracted by using liquid-liquid extraction with 1:1 ethyl acetate-water. The ethyl acetate extract yield was 5.7% (w/w). The ethyl acetate extract was further fractionated by using column chromatography with gradien elution with chloroform and ethyl acetate. Four fractions were obtained with fraction 1 (Rf = 0.95 in 1:1 chloroform-ethyl acetate eluent) was the most active fraction with LC50 of 35.46 ppm and 12% (w/w) yield. This result showed that fraction 1 was potencial as anticancer. Phytochemical test of fraction 1 gave positive results for alkaloids, saponins, steroids, triterpenoids, and tannins.
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Judul: Gelombang soliter internal pada lapisan atmosfiri yang memiliki perubahan kecepatan angin yang cepat
Abstrak: Gelombang internal adalah suatu gelombang yang terjadi di dalam suatu fluida. Gelombang ini muncul karena adanya perubahan rapat massa di setiap lapisan di dalam fluida. Salah satu gelombang internal yang ditemui di lappisan atmosfir adalah gelombang soliter internal, seperti yang terjadi pada fenomena "morning glory" di Australia. pada fenomena "Morning glory" terjadi penurunan tekanan hingga bebrapa milibar.
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