Judul: The Inhibition of Water and Ethanol Extracts of Tamarind Leaves and Kunci Pepet Rhizomes on Pancreatic Lipase in Vitro.
Abstrak: Tamarind and kunci pepet has been used traditionally as herbal medicine to reduce body weight or used as antiobesity. But the mechanism in vitro of this herbal in reducing body weight has not been known yet. The objective of this research is to evaluate the these herbal as antiobesity by their water and ethanol extracts capability in inhibiting pancreatic lipase activity in vitro at pH 8, incubation time 45 minutes, and temperature 40°C. Pancreatic lipase used in this research was human pancreatic lipase with concentration of 1.4×10-5 μg/μl and the substrate was sesame oil with concentration of 16.2 μg/μl. The water and ethanol extracts of tamarind leaves contained alkaloids, flavonoids, saponins, steroids, and tannins. Water extract of kunci pepet contained alkaloids, flavonoids, saponins, and tannins, while ethanol extract contained alkaloids, flavonoids, saponins, and triterpenoids. The results of tamarind leaves extracts showed that ethanol extract in concentration of 150 ppm had the highest inhibitory effect, with the value of 49.0%. Water extract of kunci pepet at concentration of 200 ppm had the highest inhibition, with the value of 65.1%. These values were higher than inhibitory effect of Xenical® 100 ppm as the positive control, with the inhibition value of 10.6%
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Judul: Khasiat Ekstrak Rimpang Kunci Pepet dan Buah Asam Gelugur sebagai Pelangsing secara In Vitro dan In Vivo
Abstrak: Garcinia atroviridis (gelugor) fruits and Kaempferia angustifolia (kunci pepet) rhizomes have been traditionally used as herbal medicine to reduce body weight. The extract of these plants has been shown (in vitro) to have antiobesity activity. The objectives of this research is to evaluate the activity of the combination of these herbs‟ ethanol extracts towards human pancreatic lipase activity by in vitro analysis (pH = 8.0, incubation time = 45 minutes, and temperature = 40 °C) and mouse pancreatic lipase by in vivo analysis. The combined extracts activity towards human pancreatic lipase was analyzed using lipase concentration of 1.4 х 10-6 μg/μL with sesame oil (0.243 μg/μL) as the substrate. The in vivo test were conducted to female mice by investigating their body weight and feed consumption changes before and after the combined extract administration. The in vitro test results showed that the 1:1 gelugor–kunci pepet ethanol extract combination had the highest inhibition activity towards human pancreatic lipase (75.69%) at 20 ppm concentration. The lowest body weight average of (171.38 g) was observed in the mice group that had been admistered with 564 mg combined extract per 200 g body weight. Their average feed consumption decreased from 30.13 g to 19.87 g per day. These results gave conclusion that the combined gelugor–kunci pepet ethanol extract is able to inhibit human pancreatic lipase activity, decrease mouse body weigth and appetite.
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Judul: Karakteristik Barisan Eksak Pendek HomR(N, ) dan HomR( ,N)
Abstrak: Module merupakan generaIisasi dari ruang ve}ctor, dimana pada ruang vektor skalar-skalamya berasal dati suatu lapangan (field) sedangkan pada module skaJar-skalamya merupalam unsur-unsur dan suatu ring R dengan unsur satuan. Dari suatu grup komutatif yang unsur-unsumya dipadukan dengan unsur-unsur dart suatu ring R, maka akan mengbastlk.an yang namanya R-module. Himpunan seroua fungsi homomorfisma yang memetakan dati R-module M ke R-module N dinotasikan sebagai HomiM,N), dimana HomiM,N) juga merupakan suatu R-module.
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