Judul: Peranan Pemimpin Informal dalam Keberlanjutan Kelompok  (Kasus : Gapoktan Ternak Domba Mekar Jaya, Desa Kadipaten,  Kecamatan Kadipaten, Kabupaten Majalengka, Propinsi Jawa  Barat)
Abstrak: This research take the theme about the role of Informal Leaders in Sustainability process of farmers group. The group here is Farmers sheep groups united that called Mekar Jaya. The frame of this research think that the sustainabilty of Farmers group is influenced by several factors. Those are internal factors of group, The role of informal leaders, afld external factors of group. This research also want to see about The rank or stage of sustainability of group itself. The sample of research is about 79 peoples who is the members of group. The data was collected by using quitiinary and depth interview. The survei has conducted since March until April 2002. Finnaly, the data was analyzed by using Tau-kendall technique to explain correlation among sustainability of group with the factors that can influence it. Sosiometry technique is also using to find the cliques and the leaders in group. The analysis is completed by explaining the development stage of group with planned change method.
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Judul: Efektivitas Kepemimpinan Gapoktan Mekar Sejahtera dalam Peningkatan Kedinamisan Kelompok Tani di Desa Cipelang Bogor
Abstrak: Improving dynamics of farmer groups can be supported by various factors, includes the characteristics of the group members, the Gapoktan programs, and the leadership effectiveness. The purpose of this study is to identify the characteristics of the members, analyze what programs are implemented, analyze the level of effectiveness of Gapoktan, and the relationship with the dynamic level of the farmer group members of Gapoktan. There are three farmers groups in this studied, named Mekar Sejahtera, Mekar wangi, and Harapan Sejahtera. The technique used in this study are quantitative and qualitative. The result show that amongst the three farmers groups. The differences in terms of their speciality, horticulture (Mekar Sejahtera), processing the holticulture products (Mekar Wangi),, and rice fields (Harapan Sejahtera). However, from the corelation test shows that there is no correlation between the characteristics of member, the Gapoktan programs, and the effectiveness of leadership with the dynamic level of the farmer group members of Gapoktan.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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