Judul: Analisis wilayah dan perencanaan penggunaan Kabupaten Boven Digoel - Propinsi Papua
Abstrak: Penduduk etnis Papua di Kabupaten Boven Digoel pada umumnya hidup dari bercocok tanam secara tradisional dengan menanam komoditas lokal yang rendah kualitasnya sehingga memiliki daya saing rendah di pasar serta dengan memanfaatkan lahan secara berpindah-pindah dan terpencar. Pola pemukiman yang relatip kecil-kecil lebih kurang 50 kepala keluarga tiap kampung dan letaknya berjauhan satu dengan yang lainnya, mengakibatkan sulitnya memperoleh pelayanan sosial dari pemerintah. Penelitian ini bertujuan (1) Menganalisis lereng untuk menentukan kelas lereng sebagai indikasi terhadap potensi lahan, (2) Menyusun arahan penggunaan lahan, (3) Menyusun zonasi wilayah yang dapat digunakan untuk kawasan lindung dan kawasan budidaya, dan (4) Menyusun arahan pengembangan desa dan distrik.
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Judul: Analisis disparitas pembangunan wilayah di Provinsi Papua Barat
Abstrak: Although economic growth has increased over 2005-2008 period, macro economics condition showed an imbalance among the regencies/cities. Based on analysis using Entropi Index, Williamson Index, Theil Index, Location Quontient, Shift Share Analysis and Panel Data Regression, it showed that horizontal gap exist caused by variation in GDRP per capita, population, funding balance allocation and human development index. In general, agriculture sector has contributed greatly to economic growth, although it has experienced a transition to the industrial and service sectors. The results also show sectors of mining and quarrying, manufacturing industry, transport and communication and finance sector have uneven distribution. Local government should be looking forward how to build new paradigm based on leading sectors as prime mover to reduce inequality.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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