Judul: Aktivitas ekstrak etanol-air daun kari (Murraya koenigii) sebagai hepatoprotektor pada tikus putih galur Sprague Dawley
Abstrak: Curry leaves (Murray koenigii), a traditional Indian medicinal plant is one of the herbal plants that has been reported to have high in vitro antioxidant activity. This study was designed to investigate phytochemical compound and hepatoprotective activity of ethanol:water (1:1) extract of curry leaves (EWEC) on paracetamol toxic dose induced acute liver damage in Sprague Dawley rats in vivo. Hepatoprotection activity was measured by using biochemical parameters such as enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST) serum level and to observe the histopathology study of liver. Twenty five rats were divided into 5 groups: normal group (N), negative control group/KN (paracetamol 500 mg/Kg BB), positive control group/KP (Curliv-plus® 42,86 mg/Kg BB), EWEC groups doses 200 mg/Kg BB and 300 mg/Kg BB. Curry leave was extracted with a solvent mixture of ethanol:water (1:1) which resulted about 19,2% rendement. Phytochemical test indicates that EWEC contains alkaloids, saponins, steroids, and tannins. Transaminase enzyme serum analysis shows that the induction of EWEC 300 and KP treatment gives a significant effect (p<0.01) on hepatoprotective compared to EWEC 200. However, liver histopathology shows that there is a necrosis hepatocytes on KN group, regeneration on KP group, vacuolisation on EWEC 200, and normal cells on EWEC 300. These results indicate that the antioxidant of EWEC is potential to protect liver cells.
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Judul: Efek Hepatoprotektif Ekstrak Etanol Buah Bakau (Rhizophora mucronata Lamk.) pada Tikus Putih Galur Sprague Dawley Secara In Vivo
Abstrak: Imfflamation in liver tissue caused by free radical metabolism results of toxic compounds such as alcohol, paracetamol, and carbon tetrachloride (CCl4) cause prevalence of liver disease more increased. This research was conducted to investigate antioxidant activity of propagule mangrove (R.mucronata) as a hepatoprotector and determined the level effect of specific liver enzymes, liver MDA, and histopathological studies. Results showed ethanol extract of mangrove propagule has antioxidant activity about 0,72 ppm. Treatment of propagule mangrove extract had a hepatoprotective effect on liver tissue were illustrated by enzyme levels of AST, ALT, MDA, and histopathological studies. Results showed that the best dose showing optimum recovery effect in level AST enzyme was 1 mg/kg BW with activity about 23,6 U/L, in level ALT enzyme was 5 mg/kg BW activity 14,3 U/L, level of MDA was 5 mg/kg BB activity 62,12 U/L. Highest hepatoprotective activity in histopathological studies showed by 5 mg/kg BB dosing.
Keyword: hepatoprotective., propagule mangrove (R.mucronata), antioxidant

Judul: Asymptotic Distribution of Estimator for the Intensity Function of a Doubly Periodic Poisson Process
Abstrak: In this manuscript, estimation of the intensity function of a doubly periodic Poisson process is discussed. It is assumed that only a single realization of the Poisson process is observed in a bounded window [0,n]. It is also assumed that the period of the intensity function is known. The rate of consistency and asymptotic normality of the estimator are formulated. Finally, a confidence interval for the local intensity function is also formulated.
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