Judul: Pengaruh Proses Pembuatan Virgin Coconut Oil (VCO) Terhadap Aktivitasnya sebagai Penurun Kadar Glukosa Darah pada Tikus Diabetes Melitus
Abstrak: Virgin Coconut Oil (VCO) has been produced nationally or internationally in various processing methods. Each of the processing method has claimed its own excellence, especially on its lauric acid content that found highest in VCO product. Based on that point of view, the research was conducted with the objective to study the effect of various processing methods in producing VCO on the bioactive compound of saturated medium chain fatty acids (MCFA, C8-C12) activities in reducing blood glucose of the diabetes mellitus (DM) rats. On the research used the Sprague Dawley white male rats. The rats were cared and grouped into healthy rats and DM rats. The DM rats achieved by adapting the rats for six days, followed for one night without giving any feeding prior to intraperitoneal way induction by using 110 mg alloxan solution per kg rats’ weight. After two days the content of rats blood glucose were then to be checked. The rats suffered DM if they had glucose content more than 200mg/dL. VCO produced without applying heat, VCO produced by applying controlled heat, also coconut cooking oil as a coconut oil which applied severe heat and chemically produced, were then given forcibly as medicine to each 5 DM rats. Meanwhile as a control, we made a group of positive control that suffered DM and a negative control as another health group (did not suffer DM). The two groups of control were not given the VCO or coconut cooking oil, but they were given drinking water. Each of the 5 groups of the rats were then observed during 28 days on the developing of the body’s rats weight at every two days, the amount of feed consumed at every day, blood glucose content at every 4 days, and at the end of the observing on the 29th day all of the rats were then terminated to be analyzed of theirs cholesterol level. Based on chemical analysis it was recognized that the content of fatty acid on two kinds of VCOs and coconut cooking oil is relatively no different. The content of lauric acid on VCO without heating was 51.5%, and on controlled heating VCO was 51.0% while on coconut cooking oil was 49.8%. Method of VCO processing, did not give significantly difference on the panelist preferences. It was statistically measured that either coconut cooking oil or VCO gave no significantly difference impact on the increasing of weight rats being experimented. The method of processing VCO and coconut cooking oil did not have significant impact on level 5% toward the percentage of blood glucose value on rats suffering DM. VCO without heating has tightly negative correlation on reducing glucose content. VCO did not give any impact at level 5% on total cholesterol content, HDL, LDL and triglyceride on rats’ blood serum suffering from DM.
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Judul: Gambaran Imunohistokimia Antioksidan Superoksida Dismutase pada Jaringan Hati Tikus Diabetes Mellitus yang diberi Virgin Coconut Oil (VCO).
Abstrak: Virgin coconut oil atau minyak kelapa murni saat ini umum digunakan antara lain untuk pengobatan beberapa penyakit. Secara empiris dilaporkan, minyak kelapa murni bermanfaat dalam menurunkan kadar glukosa darah. Penelitian ini bertujuan untuk melihat pengaruh pemberian minyak kelapa murni/VCO terhadap profil antioksidan intraseluler copper,zinc-superoxide dismutase (Cu, Zn-SOD) pada jaringan hati tikus diabetes mellitus. Kondisi diabetes mellitus didapat dengan cara induksi alloxan yang dapat merusak sel β Pulau Langerhans. Sebanyak 25 ekor tikus jantan galur Sprague dawley dikelompokkan menjadi 5 kelompok, yaitu (1) kelompok kontrol negatif (K-), (2) kelompok kontrol positif/diabetes (K+), (3) kelompok diabetes dengan pemberian VCO A (VA), (4) kelompok diabetes dengan pemberian VCO B (VB), (5) kelompok diabetes dengan pemberian minyak goreng (MG). Dosis aquadest, VCO, dan minyak goreng yang diberikan 5ml/ekor/hari selama 28 hari. Jaringan hati diambil di akhir perlakuan lalu diproses dengan metode embedding paraffin. Potongan jaringan hati diwarnai dengan Hematoxylin Eosin (HE) dan imunohistokimia terhadap Cu,Zn-SOD. Pemberian VCO menunjukkan gambaran morfologi hati yang lebih baik dibandingkan dengan kelompok kontrol positif dan kelompok minyak goreng. Pemberian VCO dapat meningkatkan kandungan Cu,Zn-SOD pada jaringan hati tikus diabetes mellitus dibandingkan dengan kelompok kontrol positif dan minyak goreng. Pemberian VCO A menunjukkan profil antioksidan Cu,Zn-SOD yang lebih baik dibandingkan kelompok perlakuan VCO B.
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Judul: Peranan Pesantren dalam Pembangunan Pedesaan
Abstrak: Pesantren (pondok atau pondok pesantren) adalah suatu lembaga pendidikan keagamaan Islam yang pada umumnya tumbuh di kalangan masyarakat pedesaan. Pertumbuhannya merupakan hasil refleksi pimpinan pesantren dan masyarakat terhadap kebutuhan masyarakat sekitar. Disamping sebagai lembaga pendidikan keagamaan, diharapkan pesantren dapat berperan sebagai lembaga sosial kemasyarakatan yang dapat membantu pemerintah dalam menyebar luaskan inovasi pembangunan kepada masyarakat, dan menggerakkan masyarakat agar berperan serta dalam pembangunan.
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