Judul: Hematological Profiles of Dogs Received Single Dose of Sarolaner Anti-Ticks Drug, Hematological Profiles of Dogs Received Single Dose of Sarolaner Anti-Ticks Drug
Abstrak: ABSTRAK NURMASITA. Profil Hematologi Anjing Setelah Pemberian Obat Anti Caplak Sarolaner Dosis Tunggal. Dibimbing oleh ANITA ESFANDIARI DAN SUPRATIKNO. Sarolaner merupakan obat baru anti caplak golongan isoksazolin yang efektif melawan infestasi caplak pada anjing. Penelitian ini bertujuan untuk mempelajari profil hematologi anjing yang diberi obat anti caplak berbahan aktif sarolaner dosis tunggal. Sebanyak lima ekor anjing bercaplak digunakan dalam penelitian ini. Anjing diberi obat anti caplak berbahan aktif sarolaner dengan dosis tunggal sebesar 2 mg/kg BB secara oral. Sampel darah diambil dari vena cephalica antebrachii sebelum diberikan sarolaner (H0, pre-treatment), pada H+7 (7 hari post-treatment), dan pada H+30 (30 hari post-treatment) untuk dianalisis terhadap parameter hematologi meliputi jumlah eritrosit, kadar hemoglobin, nilai hematokrit, dan indeks eritrosit (nilai MCV dan MCHC). Hasil pengamatan menunjukkan bahwa terdapat perbedaan nyata pada nilai hematokrit pada H+7 dan H+30 (P<0.05), namun tidak ada perbedaan nyata pada jumlah eritrosit, kadar hemoglobin, nilai MCV dan nilai MCHC (P>0.05) pada periode waktu yang sama. Pemberian obat anti caplak berbahan aktif sarolaner dosis tunggal sebesar 2 mg/kgBB pada anjing bercaplak mampu meningkatkan rataan nilai hematokrit pada hari ke-7 dan 30 setelah pemberian. Kata kunci: anjing, caplak, profil hematologi, sarolaner., ABSTRACT NURMASITA. Hematological Profiles of Dogs Received Single Dose of Sarolan- er Anti-Ticks Drug. Supervised by ANITA ESFANDIARI and SUPRATIKNO. Sarolaner is a new anti-tick from the isoxazoline group, effective against tick infestations in dogs. The objective of this study was to read the hematological profile of dogs that were given a single dose of anti-tick with sarolaner active in- gredient. There are five ticked dogs used in this study. Anti-tick were given to the dogs with sarolaner active ingredient in a single dose of 2 mg/kg body weight via oral. Blood samples were taken from the cephalic antebrachial vein. The samples were taken before being given a sarolaner (H0, pre-treatment), at H+7 (7days post-treatment), and H+30 (30 days post-treatment). The samples were analyzed for hematological parameters, including the number of erythrocytes, hemoglobin level, hematocrit value, and erythrocyte index (MCV and MCHC values). The re- sults showed that there was a significant difference in the hematocrit value at H+7 and H+30 (P<0.05), but there was no significant difference in the number of erythrocytes, the level of haemoglobin, MCV values, and MCHC values (P>0.05) in the same period. The administration of anti-tick with sarolaner active ingredient in a single dose of 2 mg/kg BW in ticked dogs increased the average hematocrit value on the 7th and 30th days after administration. Keywords: dog, hematological profile, sarolaner, tick.
Keyword: dog, hematological profile, sarolaner, tick

Judul: The Profile of Urea Nitrogen and Blood  Creatinine in Dogs Treated by Sarolaner Anti tick Medication at Direktorat Polisi  Satwa Baharkam Polri Kelapa Dua Depok
Abstrak: Blood Urea Nitrogen (BUN) dan kreatinin darah merupakan parameter yang dapat menunjukkan adanya gangguan fungsi ginjal. Penelitian ini bertujuan menganalisis profil BUN dan kreatinin darah anjing yang diberikan anti caplak berbahan aktif sarolaner. Sarolaner dalam dosis tunggal diberikan secara per oral kepada 5 ekor anjing yang terinfestasi caplak, kemudian dilakukan pengambilan darah melalui vena cephalica antebrachii. Pengukuran kadar BUN dan kreatinin darah anjing dilakukan pada sehari sebelum perlakuan (H-0), seminggu (H+7), dan sebulan setelah perlakuan (H+30). Alat yang digunakan untuk mengukur kadar BUN dan kreatinin darah adalah Arkray Spotchem TM EZ 4430. Data profil BUN dan kreatinin darah kelima anjing berdasarkan waktu pengamatan dianalisis menggunakan uji one way ANOVA. Hasil penelitian menunjukkan bahwa tidak terdapat perbedaan nyata pada kadar BUN dan kreatinin darah anjing di berbagai waktu pengamatan (P>0.05). Rata-rata kadar BUN dan kreatinin darah anjing masih berada dalam rentang normal. Hal ini dapat mengindikasikan bahwa pemberian anti caplak berbahan aktif sarolaner dosis tunggal tidak mempengaruhi fungsi ginjal., Blood Urea Nitrogen (BUN) and blood creatinine are parameters that can indicate impaired kidney function. This study aims to analyze the profile of BUN and blood creatinine in dogs that are treated with a single dose of sarolaner-active ingredients. Sarolaner in a single dose was given orally to 5 dogs that were infested with ticks, then blood was drawn through the cephalic antebrachii vein. Measurements of BUN and dog blood creatinine were carried out one day before treatment (H-0), a week (H+7), and a month after treatment (H+30). The instrument used to measure BUN and blood creatinine levels was Arkray Spotchem TM EZ 4430. Data on BUN and blood creatinine profiles of the five dogs based on time of observation were analyzed using the one way ANOVA test. The results showed that there was no significant difference in the levels of BUN and blood creatinine in dogs at various observation times (P>0.05). The average BUN and blood creatinine levels of dogs were still in the normal range. This may indicate that the administration of a single dose of Sarolaner does not affect kidney function.
Keyword: BUN, Creatinine, dog, Sarolaner

Judul: Construction of Strongly Optimal Binary Linear Code with Minimum Distance 9 and 11
Abstrak: A binary linear code of length n over q F is a subspace of n q F . A code has three parameters that attached to it, namely length, dimension, and minimum distance. A code with length n, dimension k and minimum distance d is often called [n, k, d ]-code. Usually, when two parameters are given, then we want to find a code that has the best value for the last parameter. Based on Gilbert- Varshamov bound, if a [n, k, d ]-code exists and can not be expanded, we call it a strongly optimal code. In this paper, we construct strongly optimal code with minimum distance 9 and 11. In constructing the code, we created a theorem and algorithm based on Gilbert-Varshamov bound before we implement the algorithm to MAPLE programming language. Because of computational limitations, the program can only construct up to k = 10 for d = 9 and k = 12 for d = 11.
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