Judul: Perencanaan Lanskap Ekowisata Sibanggor di Daerah Penyangga Taman Nasional Batang Gadis Kabupaten Mandailing Natal
Abstrak: Sibanggor merupakan daerah penyangga Taman Nasional Batang Gadis yang terletak di Kecamatan Puncak Sorik Marapi, Kabupaten Mandailing Natal, Sumatera Utara. Sibanggor mencakup tiga desa yaitu, Sibanggor Jae, Sibanggor Tonga, dan Sibanggor Julu; yang memiliki beragam objek dan atraksi wisata alami dan budaya seperti, fumarola, adat istiadat masyarakat, dan arsitektur tradisional yang berpotensi sebagai kawasan wisata. Kawasan ini memiliki keanekaragaman hayati berupa flora dan fauna pegunungan. Perpaduan antara keunikan budaya lokal dan keindahan sumber daya alam di dalamnya menjadikan kawasan Sibanggor berpotensi untuk dikembangkan sebagai kawasan ekowisata. Kegiatan wisata di Sibanggor saat ini tumbuh secara sendirinya, tetapi belum terlaksana dengan optimal karena belum didukung dengan sarana dan prasarana yang cukup memadai. Pengembangan Sibanggor sebagai daerah penyangga taman nasional sudah dilakukan oleh Balai TNBG tetapi belum terintegrasi dengan baik. Maka, perlu dilakukan studi untuk perencanaan lanskap kawasan ekowisata. Tujuan dari penelitian ini adalah menyusun perencanaan lanskap ekowisata Sibanggor di daerah penyangga Taman Nasional Batang Gadis dengan pendekatan klasifikasi kawasan ekowisata yang dikembangkan oleh Page dan Dowling (2002). Adanya perencanaan ekowisata Sibanggor diharapkan dapat menjaga kelestarikan taman nasional dan berkelanjutan. Metode perencanaan lanskap ini didasarkan pada analisis aspek fisik dan biofisik, sosial, ekonomi, budaya, dan aspek wisata yang dilakukan secara spasial dan deskriptif. Perencanaan lanskap didasari pada konsep ekowisata yang mempunyai nilai edukatif dan rekreatif dengan pengenalan keragaman hayati Sibanggor sebagai tema utama. Perencanaan lanskap menghasilkan rencana ruang, sirkulasi, aktivitas, fasilitas, vegetasi serta rencana daya dukung.
Keyword: Ecotourism, national park, buffer area, landscape planning.

Judul: Landscape Planning of Ecotourism in Bantaragung Village, Mount Ciremai National Park Based on Bioregion
Abstrak: Desa Bantaragung merupakan desa penyangga dari kawasan Taman Nasional Gunung Ciremai dan memiliki potensi Objek Daya Tarik Wisata Alam (ODTWA) yang termasuk ke dalam zona pemanfaatan serta terdapat berbagai macam potensi alam dan budaya yang dapat menjadi sebuah atraksi untuk dijadikan sebuah kawasan ekowisata dengan perencanaan yang disesuaikan dengan ekologi kawasan. Tujuan dari penelitian ini adalah menyusun rencana lanskap ekowisata di kawasan Desa wisata Bantaragung, Taman Nasional Gunung Ciremai. Penelitian dilakukan dalam empat tahapan, yaitu inventarisasi, analisis, sintesis, dan perencanaan lanskap. Identifikasi dan unit analisis diterapkan secara spasial pada unit bioregion, unit lanskap dan unit tempat berdasarkan kualitas objek dan daya tarik wisata yang mengacu pada Ecotourism Opportunity Spectrum (ECOS) yaitu ecogeneralist, intermediate, ecospecialist. Hasil dari penelitian dituangkan berupa rencana lanskap ekowisata di kawasan Desa wisata Bantaragung berdasarkan unit-unit bioregion. Selain rencana lanskap disusun juga rencana tata ruang, touring plan disertai dengan ilustrasi pendukung., Bantaragung Village is a buffer village of the Mount Ciremai National Park area. It has the potential for a Natural Tourism Attraction Object (ODTWA) which is included in the utilization zone. There are various kinds of natural and cultural potential that can become an attraction to become an ecotourism area with customized planning with the regional ecology. This research aims to develop an ecotourism landscape plan in the Bantaragung Tourism Village area, Mount Ciremai National Park. The research was conducted in four stages: inventory, analysis, synthesis, and landscape planning. Identification and analysis units are applied spatially to bioregion units, landscape units and place units based on the quality of tourism objects and attractions that refer to the Ecotourism Opportunity Spectrum (ECOS) namely ecogeneralist, intermediate, ecospecialist. The research results are outlined in the form of an ecotourism landscape plan in the Bantaragung Tourism Village area based on bioregion units. In addition to the landscape plan, a spatial plan, and a touring plan is also prepared, accompanied by supporting illustrations.
Keyword: Bantaragung Village, Ecotourism Opportunity Spectrum (ECOS), Ecogeneralist, Intermediate, Ecospecialist, Tourism object and attraction (ODTW)

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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