Judul: Aktivitas Antioksidan dan Antiinflamasi In Vitro serta Kandungan Kurkuminoid dari Temulawak dan Kunyit Asal Wonogiri
Abstrak: This research examined antioxidant and anti-inflamantory activities of Curcuma xanthorrhiza RoxB. and Curcuma domestica Val. from Wonogiri. The main bioactive compounds functioning as antioxidant and anti-inflamantory are curcuminoid. The previous research reported that curcuminoid compound is present in C. xanthorrhiza RoxB. and C. domestica Val. The antioxidant potency of the sample was detected by DPPH (2,2-difenil-1-pikrilhidrazil) method. Results showed that the antioxidant potency of C. xanthorrhiza RoxB. is higher than that of C. domestica Val. from Wonogiri. IC50 value of C. xanthorrhiza RoxB. was 53.13 ppm and C. domestica Val. Was 61.72 ppm. Anti-inflamantory activity was analyzed by in vitro cyclooxygenase 2 (COX2) inhibition method. The best inhibition activity against of COX2 is showed by C. domestica Val. in amount of 47.45% and value of C. xanthorrhiza RoxB is 87.19%. Curcuminoid Content of C. xanthorrhiza RoxB. and C. domestica Val. was measured by High Performance Liquid Chromatography (HPLC). Results showed that curcuminoid content of C. domestica Val. was 74.57 mg/g and C. xanthorrhiza RoxB. was 20.04 mg/g.
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Judul: Bioaktivitas Antioksidan dan Antiinflamasi Secara In Vitro serta Kandungan Kurkuminoid Temulawak dan Kunyit Asal Sukabumi
Abstrak: Curcuma xanthorrhiza and Curcuma domestica are kind of medicinal plants which have many health benefits. Both of them have curcuminoid content which is useful as an antioxidant and anti-inflamatory. In this study, ethanol extracts of C. xanthorrhiza and C. domestica promising lines from Sukabumi, Indonesia were investigated for the presence of curcuminoids, antioxidant and anti-inflamatory activities. HPLC method were used to determined curcuminoids content. The antioxidant (radical scavenging) potential of the samples was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical method. While for the anti-inflamatory activity, the in vitro cyclooxygenase 2 (COX2) inhibition method was used. The curcuminoid content of C. xanthorrhiza and C. domestica were 31.27 mg/g and 66.32 mg/g, respectively. IC50 values for DPPH radical scavenging activity were 81.99 μg/mL and 73.31 μg/mL, with C. domestica having lowest value and most potent than C. xanthorrhiza. Percent inhibition values for COX2 inhibitor activity were 74.84 % and 67.96 %, with C. domestica having the highest value. In this study, the ethanol extracts of C. domestica promosing line from Sukabumi of Indonesia exhibited most in curcuminoids content, antioxidants properties and anti-inflamatory activity than C. xanthorrhiza promosing line.
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Judul: Construction of Strongly Optimal Binary Linear Code with Minimum Distance 9 and 11
Abstrak: A binary linear code of length n over q F is a subspace of n q F . A code has three parameters that attached to it, namely length, dimension, and minimum distance. A code with length n, dimension k and minimum distance d is often called [n, k, d ]-code. Usually, when two parameters are given, then we want to find a code that has the best value for the last parameter. Based on Gilbert- Varshamov bound, if a [n, k, d ]-code exists and can not be expanded, we call it a strongly optimal code. In this paper, we construct strongly optimal code with minimum distance 9 and 11. In constructing the code, we created a theorem and algorithm based on Gilbert-Varshamov bound before we implement the algorithm to MAPLE programming language. Because of computational limitations, the program can only construct up to k = 10 for d = 9 and k = 12 for d = 11.
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