Judul: Pola Pertumbuhan Remaja Usia 15 Sampai 20 Tahun  Di Wilayah Bogor
Abstrak: Growth continues from conception, pregnancy, baby, children, adolescence until adulthood. Adolescence growth pattern description can be used as a reference. This research aims to determine normal growth pattern of height, weight, and body mass index of Bogor adolescence aged 15 to 20. Cross-sectional sampling were conducted to get probands from SMPN 2, SMUN 3, SMUN 4, SMUN 8 Bogor City, and IPB in order to obtain probands with socioeconomic background above average. Growth pattern derives from 50th percentile. Male adolescence height grows until the age of 18 and ceases to grow afterwards. Female adolescence height ceases to grow at the age of 18 years old. Maximum male adolescence height is 169.27 cm while maximum female height is 156.74 cm. Male adolescence weight increases until the age of 20 while female adolescence ceases to grow at the age of 19. Maximum male adolescence weight is 57.08 kg while maximum female weight is 50.96 kg. Body mass index of male and female adolescence increases slightly in rate. Body mass index in male and female reaches maximum in the age of 20. That is equal to 20.25 kg/m2 for male adolescence and 20.47 kg/m2 for female adolescence.
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Judul: Pola pertumbuhan tinggi badan, berat badan dan indeks massa tubuh anak Bogor usia 5 sampai 15 tahun
Abstrak: Pola pertumbuhan antarsuku bangsa mungkin saja berbeda. Ini berarti penting bagi setiap suku bangsa untuk memiliki deskripsi pola pertumbuhan sendiri sebagai referensi. Tujuan penelitian ini adalah untuk mendapatkan pola pertumbuhan normal tinggi badan, berat badan dan indeks massa tubuh anak Bogor usia 5 sampai 15 tahun. Prosedur antropometri dilakukan secara horisontal pada probandus dari TK Kartika III, SDN Pengadilan III dan SLTPN 4, Bogor dengan maksud memperoleh probandus dengan latar belakang sosial ekonomi di atas median. Probandus dalam penelitian ini merupakan penambahan pada penelitian sebelumnya di tahun 2002. Prosedur antropometri yang dilakukan adalah pengukuran tinggi badan dan berat badan serta perhitungan indeks massa tubuh. Tinggi badan anak laki-laki tumbuh secara linier sebelum usia 13 tahun lalu tumbuh pesat sejak usia itu. Pertumbuhan tinggi badan maksimal anak laki-laki mungkin dicapai setelah usia 15 tahun. Pertumbuhan tinggi badan anak perempuan meningkat hingga usia 10 tahun, melambat sejak usia 11 tahun dan hampir berhenti di usia 15 tahun. Puncak laju pertumbuhan tinggi badan anak perempuan terjadi di usia 8 tahun. Peningkatan berat badan yang cepat terjadi pada anak laki-laki sampai usia 13 tahun, dan setelah usia itu pertumbuhan berat badan melambat. Anak perempuan mengalami pertumbuhan berat badan yang cukup pesat hingga usia 14 tahun, tetapi pertumbuhan berat badannya melambat di usia 15 tahun. Indeks massa tubuh anak laki-laki tumbuh pesat sampai usia 10 tahun dan relatif stabil setelah usia tersebut. Sebaliknya, indeks massa tubuh anak perempuan terus bertambah seiring dengan bertambahnya usia.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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