Judul: Perencanaan Lanskap Rest Area Di Pantai Binangun, Lasem, Rembang, Jawa Tengah
Abstrak: Studi perencanaan ini bertujuan untuk merencanakan rest area di Pantai Binangun bagi pengguna jalan maupun wisatawan dengan meminimalkan pembahan bentuk tapak untuk menjaga kelestariannya. Selanjutnya hasil studi ini dapat dipakai sebagai alternatif bagi pemerintah daerah untuk mengembangkan kegiatan pariwisata yang memperhatikan kelestarian lingkungan.
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Judul: Perencanaan Lanskap Kawasan Rekreasi Pantai Widarapayung di Cilacap Jawa Tengah.
Abstrak: Pembangunan pariwisata terintegrasi yang dilaksanakan oleh Pemerintah Daerah Cilacap, Propinsi Jawa Tengah, yang diwujudkan dalam bentuk pengelolaan serangkaian potensi alam daerah, menuntut masing-masing obyek wisata di Cilacap untuk berkembang secara optimal. Perencanaan lanskap yang dapat mengoptimasi pemanfaatan sumberdaya alam dengan pelestarian lingkungan, sangat diperlukan untuk mencapai pembangunan berkelanjutan. Studi ini bertujuan untuk membuat suatu rencana lanskap kawasan rekreasi Pantai Widarapayung, salah satu dari serangkaian obyek wisata pantai di Cilacap yang akan dikembangkan untuk kepentingan rekreasi.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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