Judul: Potential of Active Compounds in Broadleaf Mahogany Seeds (Swietenia macrophylla) against Breast Cancer Cells using In Silico Analysis
Abstrak: Kanker payudara merupakan penyebab kematian terbesar akibat kanker di Indonesia. Namun, obat yang biasa digunakan memiliki efek samping dan menjadi resistan selama pengobatan. Ekstrak biji mahoni berdaun lebar (Swietenia macrophylla) telah teruji secara in vitro memiliki aktivitas sitotoksik pada sel kanker payudara MCF-7. Penelitian ini bertujuan memprediksi senyawa aktif dalam biji tumbuhan tersebut yang berpotensi sebagai antikanker payudara secara in silico. Senyawa aktif diprediksi dengan metode penambatan molekul, visualisasi hasil penambatan, dan analisis fisikokimia. Hasil penambatan menunjukkan 12 senyawa aktif diprediksi sebagai antikanker payudara. Visualisasi hasil penambatan menunjukkan terdapat tiga senyawa yang memiliki kesamaan mekanisme penghambatan dengan obat pembanding. Senyawa-senyawa tersebut ialah 3β,6- dihidroksidihidrokarapin, stigmasterol, dan 7-hidroksi-2-(4-hidroksi-3-metoksifenil)-kroman-4-on yang diprediksi dapat dikonsumsi secara oral.
Keyword: breast cancer, in silico, limonoid, mahogany seed, oral drug

Judul: Bioaktivitas Biji Mahoni Berdaun Lebar (Swietenia macrophylla) sebagai Antikanker
Abstrak: There are three species of mahogany in Indonesia, namely small-leaf mahogany (Swietenia mahogany), broad-leaf mahogany (Swietenia macrophylla), and Swietenia sp. This study aimed to study the toxicity of bioactive compounds in fractions of ethyl acetate extract from broad-leaf mahogany seeds, which is potencial as anticancer, by using brine shrimp lethality test. The seeds were ground into powder and air-dried. The powder was then soxhletized with nhexane. The residue was macerated in 96% ethanol. The ethanol extract was evaporated and then extracted by using liquid-liquid extraction with 1:1 ethyl acetate-water. The ethyl acetate extract yield was 5.7% (w/w). The ethyl acetate extract was further fractionated by using column chromatography with gradien elution with chloroform and ethyl acetate. Four fractions were obtained with fraction 1 (Rf = 0.95 in 1:1 chloroform-ethyl acetate eluent) was the most active fraction with LC50 of 35.46 ppm and 12% (w/w) yield. This result showed that fraction 1 was potencial as anticancer. Phytochemical test of fraction 1 gave positive results for alkaloids, saponins, steroids, triterpenoids, and tannins.
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Judul: Approximation of the Median of Poisson Distribution Using the Relation of Poisson-Gamma Distribution
Abstrak: A major drawback of median is that median cannot usually be defined in closed form, even in the cases where their distribution functions are known. This study gives an approximation of the closed form for the median of the Poisson distribution by using the relation of Poisson-Gamma distribution. The approximation uses elementary techniques based on the monotonicity of certain sequences involving tail probabilities of the Poisson distribution and the Central Limit Theorem. Furthermore, a closed form expression for the mean absolute deviation 􀜧|􀜰􀰒 􀵆 􀜯􀝁􀝀􁈺􀜰􀰒􁈻| is also studied. The median is relevant because of the fact that it minimizes the mean absolute deviation of a Poisson random variable (􀜰􀰒􁈻 by considering median as central tendency.
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