Judul: Pengaruh perubahan penggunaan dan penutupan lahan terhadap kenyamanan di Suburban Bogor Barat
Abstrak: Perkembangan kota &an m e n d perkembangan di kawasan sekitarnya. Wilayah suburban yang berbatasan dengan pusat kob &an terkena dampaknya, yaitu dengan semakin banyaknya alih h g s i lahan, khususnya ymg berupa ruang terbuka hijau (RTH). Pengaiih.Eungsian latran tersebut akan berpengaruh terhadap kenyamanan yang terkait dengm sistem iklim. Tujuan dari peaelitian ini adalah rnenyusun model pengamh perubahaa penggunaaxl dm penutupan lahan terhadap kenyamanan di Suburban Bogor Barat, memprediksi perubahan penggunaan clan penutupan l&an terhadap tingkat kenymmm di Srsbwbm Bogor Bmat, dm mefiylisiin rekomzndasi kebijakm pengpaan dan penutupan lahan di Suburban Bogor Barat.
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Judul: Pengaruh Perubahan Penggunaan Ruang Terhadap Kenyamanan Lanskap Wilayah Pengembangan Bojonagara, Kota Bandung
Abstrak: Perkembangan dan pembangunan kota berdampak pada semakin meningkatkannya jumlah penduduk kota. Hal tersebut mengakibatkan kebutuhan ruang di perkotaan semakin meningkat. Namun, dengan keterbatasan lahan, yang terjadi adalah perubahan penggunaan lahan di perkotaan. Perubahan penggunaan ruang di perkotaan ini cenderung menurunkan proporsi ruang-ruang yang sebelumnya merupakan ruang terbuka hijau atau ruang ekologis. Berdasarkan realita yang ada, fenomena penggunaan lahan yang terjadi di Wilayah Pengembangan Bojonagara adalah adanya kecenderungan perubahan penggunaan lahan dari area tak terbangun menjadi area terbangun, serta perubahan fungsi dari kawasan perumahan menjadi fungsi kawasan komersil.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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