Judul: Studi Histopatologi Potensi Radioprotektif Ekstrak Kelopak Rosela (Hibiscus sabdariffa L) terhadap Duodenum Mencit (Mus musculus) dengan Radiasi Ionisasi Radiodiagnostik Berulang
Abstrak: This study was conducted to find out the potency of Roselle (Hibiscus sabdariffa L.) as radioprotective against recurrent effect of radiodiagnostic radiation on duodenum of mice (Mus musculus). This research was to observed histophatological changes on duodenum of mice treated with roselle calyx extracts and radiation. Twenty four male mice were used in this study. They were divided into 4 groups namely control group (K) treated with 0.2 ml of NaCl 0.9 % (saline); primary radiation group (P) treated with 0.2 ml of NaCl 0.9 % (saline) and radiation 0.2 mSv; roselle group (R) treated with 0.2 ml roselle calyx extract; and primary radiation-roselle group (RP) treated with 0.2 ml roselle calyx extract and radiation 0.2 mSv. All treatments were done orally every two days for 8 weeks. Afterwards, 3 mice from each group were euthanized for organ sampling. The rest of mice were took 4 weeks of recovery. Afterwards, all mice were euthanized for organ sampling. Duodenum were fixed in Buffered Neutral Formaline (BNF) 10%, embedded in paraffin, then stained with hematoxyline and eosin (HE) and periodic-acid schiff (PAS). The result showed that RP group had lower demage of intestinal villi and numbers of goblet cell than P group. Lieberkühn crypt number of P group was increased, whereas intestinal villi height was decreased compared to R and RP groups. Roselle calyx extract (Hibiscus sabdariffa L.) showed radioprotective potency after radiation treatment on duodenum of mice.
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Judul: Studi In-vitro dan In-vivo Efek Radioprotektif Rosela (Hibiscus Sabdariffa Linn.) terhadap Radiasi Ionisasi Radiodiagnostik Berulang
Abstrak: The purpose of this study is to determine the natural radioprotective effect of ethanolic extract of roselle (Hibiscus sabdariffa L.) through the in-vitro and invivo study of mice that were exposed by ionizing radiation from recurrent radiodiagnostic. In in-vitro study, splenic lymphocytes were cultured in different concentration of ethanolic extract of roselle. Splenic lymphocytes were divided in two groups; with radiation exposure and without radiation exposure. The numbers of lymphocyte were calculated at 1, 2 and 3 days after radiation of each group. In in-vivo study, mice supplemented with ethanolic extract of roselle dose 50 mg/kg body weight prior to radiation for 60 days and 30 days after recovery for clinical and pathological evaluation. Radiation from radiodiagnostic radiography exposure performs repeated every 2 days. Forty eight adult mice were divided in 4 groups; control (K), radiation (P), roselle (R) and roselle with radiation (RP). Clinical data were collected for live survival, body weight, and peripheral blood characteristic. Pathological data were collected for relative organ weight and histopathological finding of bone marrow and spleen at 4 and 8 weeks after radiation; 8 and 12 weeks after 30 days recovery. The in-vitro study clearly showed that roselle enhances the splenic lymphocyte proliferation and maintained amount of cells (p<0.05). The in-vivo study showed that roselle maintained peripheral blood characteristic (p<0.05), however did not affect the mice live survival and body weight (p>0.05). Pathological evaluation showed that relative organ weight, hematopoietic bone marrow cells, and white pulpa area of spleen were significant different between groups (p<0.05).
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Judul: Modeling Multi-Agent in Futsal Sport Using Finite State Machine.
Abstrak: Building agents for futsal scenario requires methodologies for implementing high-level complex behavior and efficient programming. With that hypothesis in mind, this paper will show that we can develop futsal agents using simple logic and rule-based manner with Finite State Machine (FSM). FSM provides a powerful way to describe dynamic behavior of systems and components. The systems adapt specific behaviors with the main focus on how agents should behave for current situation. This research is designed with State design pattern to implement FSM in object oriented languages. In order to describe procedural aspects of the agents behavior, the state machine represented by state diagram. Because of this, we can revise behavior of agents which is triggered by external events. From this research the system can describe agent’s behavior and specified the state of the current situation. Keywords: Multi-agent, Finite State Machine, object oriented, State design pattern.
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