Judul: Toksisitas Subkronis Ekstrak Etanol 70% Daun Wungu (Graptophyllum Pictum (Linn) Griff) pada Mencit.
Abstrak: Graptophyllum pictum (L.) Griff is one of the family Acanthaceae. This plant contains alkaloid compounds, flavonoids, saponins, tannins, and steroids, as well as having antidiabetic activity. But consume this plant safely has not been test, so it needs subchronics toxicity test and histopathological observations. The subchronics toxicity of Graptophyllum pictum (L.) Griff leaf will do for 3 months. During the treatment of mice give peroral Graptophyllum pictum (L.) Griff extract daily and divide into 4 doses, they are 100 mg/kg, 500 mg/kg, 1000 mg/kg, and distilled water as control. Measurements of mice body weight and mortality observations made during the study. Mice body weight has increase during the study. Graptophyllum pictum (L.) Griff leaf ethanol extract doesn’t give number of LD50 subchronic toxicity. Number of death mice in normal groups is 4 mice, 100 mg/kg groups is 3 mice, 500 mg/kg group is 2 mice, and 1000 mg/kg is one mice. Graptophyllum pictum (L.) Griff leaf ethanol extract for dose 100 mg/kg and 500 mg/kg give damage in histopathology of kidney, heart, and lung, for dose 1000 mg/kg give damage in histopathology of kidney. Graptophyllum pictum (L.) Griff leaf ethanol extract give damage effect in organs.
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Judul: Potensi Ekstrak Etanol Daun Wungu (Graphtophyllum pictum (L.) Griff) pada Tikus Sprague-dawley Diabetes yang Diinduksi Aloksan
Abstrak: High level of glucose in blood can cause Diabetes Mellitus (DM). This desease can be treated by either chemical or herbal medicine. One of herbal plant which is expected to heal the desease DM is Wungu leaves. Glucose measurement was conducted to 7 group, normal group (K-1), negative control (K-2), positive control (K-3), ethanol extract of wungu leaves 25 mg/kg bb (K-4), 50 mg/kg bb (K-5), 100 mg/kg bb (K-6), 200 mg/kg bb (K-7). The measurement was conducted in 2 phase namely treatment phase, to determine the effect of ethanol extract of Wungu leaves on DM and post-treatment phase which is to determine the effectiveness of extract of Wungu leaves in dcreasing glucose in blood. The sample animal that is used is Sprague-dawley ratswhich is weighting ≥ 200 gram, the experimental is carried out for 21 days. The result shows that the extract of Wungu leaves effect on decreasing glucose level is blood of diabetes rats. The decreasing of glucose strat from > 200 mg/dL in day 4 to < 200 mg/dL in day 14. Post-treatment phase shows that K-3, K-5, and K-6 decrease significiently. Decreasing on K-3 indicate that glibenklamid is working good in decreasing glucose level in DM rats blood, glucose K-5 on 15th minute is lower than K-6, so it can be conclude that K-5 is more effective in decreasing glucose level on DM rats.
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Judul: Construction of Strongly Optimal Binary Linear Code with Minimum Distance 9 and 11
Abstrak: A binary linear code of length n over q F is a subspace of n q F . A code has three parameters that attached to it, namely length, dimension, and minimum distance. A code with length n, dimension k and minimum distance d is often called [n, k, d ]-code. Usually, when two parameters are given, then we want to find a code that has the best value for the last parameter. Based on Gilbert- Varshamov bound, if a [n, k, d ]-code exists and can not be expanded, we call it a strongly optimal code. In this paper, we construct strongly optimal code with minimum distance 9 and 11. In constructing the code, we created a theorem and algorithm based on Gilbert-Varshamov bound before we implement the algorithm to MAPLE programming language. Because of computational limitations, the program can only construct up to k = 10 for d = 9 and k = 12 for d = 11.
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