Judul: Aktivitas hepatoprotektor ekstrak metanol daun kari (Murraya koenigii .L.) pada tikus putih Sprague dawley, Activity of Curry Leaf (Muraya koenigii. L.) Methanol Extract as Hepatoprotector in Sprague dawley Rats
Abstrak: Curry leaf is being thought as hepatoprotector againts liver damage caused by hepatotoxic agent such as paracetamol. This study was assesing the activity of curry leaf extract in reducing the activity of ALT (alanine aminotransferase) and AST (aspartate aminotransferase) in rats were given high dose paracetamol. Total of 25 rats were used in this research which were divided into 5 experimental groups as follows: normal control group (N), negative control group (KN) (paracetamol dose 500 mg/Kg BW were given 21 days), positive control group (KP) (curliv dose 42.86 mg/Kg BW were given 21 days), dose 200 mg/Kg BW extract group (ED200), and dose 300 mg/Kg BW extract group (ED300). Extracts were given 7 days before paracetamol treatment and continous until end of experiment. Pytochemistry test results showed that curry leaf methanol extract contain alcaloids, tannins, saponins, and steroids. Extract group had not significantly reduced ALT and AST activity (p>0.05) compared to N group. Decreasing ALT and AST activity in ED200 group is 16.21% and 33.82%. Decreasing ALT and AST activity in ED300 group is 33.82% dan 62.60%. Methanol extract curry leaf had hepatoprotector activity although not significantly differences.
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Judul: Ekstrak air undur-undur (Myrmelon sp.) sebagai hepatoprotektor tikus jantan sprague dawley yang diinduksi parasetamol
Abstrak: Giving over doses paracetamol to animal can destroy liver cell. This matter is marked by increasing of alanin aminotransferase’s activity or ALT and aspartat aminotransferase or AST. One of alternatives to repair liver cell by giving undurundur’s extract in the correct dose. This research aims to determine optimal extract dose of undur-undur as antihepatotoksik by temulawak as control. The substance trusted has ability prevents oxidative damage so that can repair liver cell. Animal which has been induced by paracetamol during 14 day is given the undur-undur’s extract with dose 5 mg/kg, 10 mg/kg, and 15 mg/kg during 21 days. Taking sample blood conducted on day 0, 14, and 35. Activity AST and ALT has degradation after day 14 until day 35. Among third of the undur-undur’s extract dose, the biggest extract which can decrease activity of AST and ALT is dose 10 mg/kg body wight that is from 115,5 U/L become 85,5 U/L (25.97%) for ALT and from 184.75 U/L become 153.75 U/L (16.78%) for AST although not afford with analysis statistic (α=0.05).
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Judul: Asymptotic Distribution of Estimator for the Intensity Function of a Doubly Periodic Poisson Process
Abstrak: In this manuscript, estimation of the intensity function of a doubly periodic Poisson process is discussed. It is assumed that only a single realization of the Poisson process is observed in a bounded window [0,n]. It is also assumed that the period of the intensity function is known. The rate of consistency and asymptotic normality of the estimator are formulated. Finally, a confidence interval for the local intensity function is also formulated.
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