Judul: Efek Pemberian Ekstrak Etanol Temu Ireng (Curcuma Aeruginosa Roxb.) pada Proliferasi Sel Lestari Tumor THP1 dan A549 Secara In Vitro.
Abstrak: The use of plant extracts is one of alternative ways to heal tumor diseases. The purpose of this research is to study the effect of ethanol extract of temu ireng (Curcuma aeruginosa Roxb.) on proliferation of THP1 and A549 cell lines. The extract concentration used were 0 ppm (as a negative control), 12.5 ppm, 25 ppm; 37.5 ppm and 50 ppm, doxorubicin as a positive control, and the treatment were in three replications. All data were analyzed statistically by ANOVA and Duncan test. The results showed that inhibition activity of temu ireng ethanol extract on THP1 and A549 cell line proliferation were significantly different (p<0.05) than negative control. Inhibition activity were as higher as treatment dose and significantly different (p<0.05) between dose, except 25 ppm and 37.5 ppm dose on THP1 cell line. The highest inhibition was achieved at 50 ppm dose as 85,8% for THP1 cell line and 73.3% for A549 cell line. Based on this results, we concluded that temu ireng ethanol extract has a poliferation inhibition activity on both cell lines and has a potential substance to be develop as antitumor.
Keyword: A549, curcuma aeruginosa Roxb, inhibition activity, THP1

Judul: Pengaruh Penambahan Ekstrak Etanol Temu Ireng (Curcuma Aeruginosa Roxb.) Terhadap Pertumbuhan Sel Lestari Tumor Mca-B1 Dan Mcm-B2 Secara In Vitro
Abstrak: Penelitian ini bertujuan untuk mempelajari kemampuan penghambatan ekstrak etanol temu ireng terhadap pertumbuhan sel lestari tumor MCA-B1 dan MCM-B2. Penelitian dilakukan dengan menanam sel lestari tumor MCA-B1 dan MCM-B2 pada tissue culture plate 24 well dengan konsentrasi ekstrak yang berbeda sebanyak 3 kali ulangan. Konsentrasi ekstrak yang dipakai adalah 0 ppm sebagai kontrol negatif (tidak diberi penambahan ekstrak), doxorubicin 100 ppm sebagai kontrol positif, 12.5 ppm, 25 ppm, 37.5 ppm, 50 ppm. Setelah sel lestari tumor pada lubang kontrol negatif konfluens, sel dipanen dan dihitung menggunakan kamar hitung hemositometer Neubauer dengan pewarnaan trypan blue. Sel lestari diinkubasi pada suhu 37oC, 5% CO2. Hasil penelitian menunjukkan adanya aktivitas antiproliferasi ekstrak etanol temu ireng yang berbeda nyata p(<0.05) terhadap kedua sel lestari tumor MCA-B1 dan MCM-B2. Dosis ekstrak yang menunjukkan hasil paling baik adalah 50 ppm dengan aktivitas antiproliferasi sebesar 80.59% pada sel lestari tumor MCA-B1 dan 84.33% pada sel lestari tumor MCM-B2. Hasil tersebut menunjukkan potensi temu ireng sebagai tanaman yang memiliki aktivitas sebagai anti tumor.
Keyword: antiproliferasi, ekstrak temu ireng, MCA-B1, MCM-B2, sel lestari

Judul: Construction of Strongly Optimal Binary Linear Code with Minimum Distance 9 and 11
Abstrak: A binary linear code of length n over q F is a subspace of n q F . A code has three parameters that attached to it, namely length, dimension, and minimum distance. A code with length n, dimension k and minimum distance d is often called [n, k, d ]-code. Usually, when two parameters are given, then we want to find a code that has the best value for the last parameter. Based on Gilbert- Varshamov bound, if a [n, k, d ]-code exists and can not be expanded, we call it a strongly optimal code. In this paper, we construct strongly optimal code with minimum distance 9 and 11. In constructing the code, we created a theorem and algorithm based on Gilbert-Varshamov bound before we implement the algorithm to MAPLE programming language. Because of computational limitations, the program can only construct up to k = 10 for d = 9 and k = 12 for d = 11.
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