Judul: Pengembangan Kawasan Wisata Alam Gunung Galunggung Berdasarkan Permintaan Pasar
Abstrak: Kabupaten Tasikmalaya memiliki daya tarik wisata yaitu Kawasan Wisata Alam Gunung Galunggung (KWAGG). Potensi wisata yang dimiliki KWAGG belum dikembangkan secara optimal sehingga diperlukan pengembangan kawasan. Pengembangan yang dilakukan dapat disesuaikan dengan permintaan pasar terhadap KWAGG. Permintaan wisata dijadikan sebagai bahan pertimbangan untuk perencanaan potensi KWAGG karena dapat mempertemukan kebutuhan dan keinginan para wisatawan terhadap kawasan tersebut. Metode pengambilan data yang digunakan adalah observasi lapang, studi pustaka, wawancara pengelola dan penyebaran kuesioner kepada pengunjung. Hasil segmentasi yang dilakukan menunjukkan bahwa tujuan wisata merupakan tujuan yang mendominasi bagi kelompok umur 15-24 tahun dan bagi pengunjung yang berasal dari daerah Jawa Barat, khususnya Tasikmalaya. Perencanaan yang dapat dilakukan sesuai dengan segmentasi dominan yang terjadi adalah pembenahan dan perbaikan kolam pemandian, penyediaan area perkemahan, pembenahan jalan dan aksesibilitas menuju kawasan, pengelolaan kebersihan di sekitar objek wisata.
Keyword: pengunjung, perencanaan, permintaan pasar, segmentasi, Tasikmalaya

Judul: Pengembangan Wisata Alam di Kawasan Strategis Pariwisata Kabupaten Tasikmalaya Provinsi Jawa Barat
Abstrak: Tasikmalaya Regency is a strategic area, are among the popular tourist destinations and frequently visited by domestic and foreign tourist, such as Pangandaran, Garut and Bandung. It is an opportunity for development the natural tourism attraction of Tasikmalaya Regency. The research was carried out in the strategic area of tourism Tasikmalaya Regency during August until September 2012. The tools and materials used, such as stationery, digital cameras, GPS, ArcGis 9.3, Microsoft Office 2007, questionnaire, interview guidelines and analysis of the operating guidelines and objects of natural tourist attraction (ADO-ODTWA) General Directorate of PHKA 2003. The development of tourism based on the assessment ADO-ODTWA, analysis of the visitors wishes and expectations; the readiness to receive visits and thecommunity wishes and expectations; stakeholeder analysis and the strategic plan of natural tourism management. Based on the result of ADO-ODTWA assesment, the depelopment criteria of Galunggung (3325) and Karaha Bodas (2963) are very potential. Sindangkerta Beach (2885), Pamayangsari Beach (1777), Karangtawulan (2750) and Cipatujah Beach (2740) are potential. The visitors wishes and expectations are the repair, maintenance, and the provision of supporting facilities, accessibility, variety of activities, management of services, and management of visitors. The community less welcomed with the tourist visits and the tourism development especially Karah Bodas community (disagree). Wishes and expectations of the community such as increasing well-being, getting the socialization about tourism periodically to change community perception who are not ready, becoming open minded to receive visits. Demonstrated in the implementation of tourist destination, the depelopment organize the consept of religion tourism, appropriate to attitude and culture of the community. The development plan for tourism management are the development of potential tourism, human resources, along protection and resources coservation. The development of natural tourism, such as: (1) the development of a natural tourist attraction destinations by keeping the authenticity and sustainability areas, restrictions on the utilization block appropriate of envinronment resources support, making the evacuation and relocation of areas prone to natural disasters; (2) the development of activities and natural attractions differentiated based on the potencial natural tourism attraction that owned by each objects; (3) the development of facilities are development of interpretation feature and tourism map, information center, homestay, and strengthening of building and infrastructure; (4) accessibility of infrastructure development, a means of transportation, signpost direction, and the promote and information about tourism; (5) the development of human resources should be increases among others, in form of training to improve the ability of service, to be a good host, presenting various form of tourist attraction, foods, and souvenir, and natural disaster response; (6) the development of tourism through a good tourism management, prepared from the regoinal level combine with each tourism location, and build a partnership; (7) the development of tourism marketing and promotion trough electronic media (intenet, website, radio and TV) and print media (leaflet, booklet,and tourism map) periodically held a renewal according to developed by tour packages, and follow and create events that introduce attractions of nature tourism and local culture.
Keyword: 

Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
Keyword: