Judul: Faktor-faktor yang Mempengaruhi tentang Migrasi dari Gorontalo ke Kotamadya Manado
Abstrak: Pertumbuhan penduduk yang tinggi yang terjadi di pedesaan memberikan dampak kepada jumlah tenaga kerja yang semakin meningkat setiap tahunnya. Dengan demikian mendorong penduduk desa untuk bermigrasi ke kota. Tujuan penelitian adalah untuk mengetahui sampai sejauh manakah penyebab urbanisasi/migrasi terhadap tingkat pendapatan dan tenaga kerja (jenis pekerjaan) di Kotamadya Manado dan untuk mengetahui sampai sejauh manakah dampak urbanisasi/migrasi terhadap tingkat pendapatan dan tenaga kerja (jenis pekerjaan) di Kotamadya Manado.
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Judul: Analisa pendapatan migran dari desa ke kota dan analisa faktor-faktor yang berpengaruh terhadap peluang bermigrasi
Abstrak: Jumlah angkatan kerja yang meningkat setiap tahun dan tidak dibarengi dengan kesempatan kerja yang memadai menimbulkan masalah yang cukup serius . Sektor pertanian yang pada masa-masa sebelumnya mampu rnenampung tenaga kerja cukup besar , sekarang semakin berkurang kemampuannya karena tekanan penduduk terutama di pulau Jawa. Sehingga banyak tenaga kerja mencari pekerjaan disektor non pertanian yang kebanyakan tersedia dikota . Akibatnya urbanisasi semakin meningkat yang dikhawatirkan akan menimbulkan pengangguran dikota karena terbatasnya daya tampung dan berkurangnya surnber daya manusia di desa yang penting bagi perkembangan desa .
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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