Judul: Pengaruh Kurkumin terhadap Skleroderma dan Fibrosis Paru-paru Akibat Aplikasi Bleomisin pada Mencit (Mus musculus)
Abstrak: Curcumin is an curcuminoid compound of turmeric. Curcumin has been demonstrated to have anti-oxidant and anti-inflammatory properties. Bleomycin (BLM) is an anti-cancer drug which induced scleroderma and pulmonary fibrosis in human and animals. Here we investigate biological effects of curcumin on bleomycin-induced scleroderma and pulmonary fibrosis in mice through pathomorphological assesment. In this study, each group consisted of 4-6 mice ddy strain, that groups namely (i) control, mice were subcutaneously (SC) injected with 100 μl sterilized aquadest in dorsal skin, (ii) bleomisin (BLM) group, injected with 100 μl of 1 mg/ml BLM SC in dorsal skin, (iii) curcumin (CMN) group, mice were intraperitoneally (IP) injected with 100 mg/kg body weight (BW) curcumin dissolved in 0.5% carboxymethylcellulose (CMC) and injected with 100 μl sterilized aquadest SC, (iv) BLM+CMN group, injected with 100 μl of BLM 1 mg/ml SC and injected with 100 mg/kg BW CMN in 0.5% CMC IP. Injections of PBS, BLM, CMN were performed daily for four weeks period. The mice were euthanized with overdosed ketamine, and afterwards the dorsal skin and lung samples were collected and fixed in 10% buffered neutral formalin (BNF). Histopathological evaluation was performed with hematoxylin-eosin (HE) and Masson’s trichrome (MT) stains. The results showed that BLM treatment significantly decreased hair follicles number and size. Additionally, in BLM-treated group there was significant increase in skin fibrosis area and inflammatory cells (macrophage and lymphocyte) number. In the lung, repeated BLM treatment initiated higher fibrosis area and alveolar wall area fraction as compared with control. In the other hand, CMN treatment results significantly increased hair follicles number and size, significantly reduced skin fibrosis area, lower inflammatory cells number, and significantly decreased fibrosis area, reduced alveolar wall area fraction in BLM-treated mice. Conclusively, our study showed that CMN treatment may inhibit skin and lung fibrogenesis in BLM-induced scleroderma and pulmonary fibrosis.
Keyword: scleroderma, pulmonary fibrosis, mice, bleomycin, curcumin

Judul: Pengaruh Pemberian Salep Fraksi Etil Asetat Rimpang Kunyit (Curcuma longa Linn.) terhadap Persembuhan Luka Mencit (Mus musculus albinus) Hiperglikemik
Abstrak: The aim of this research was to know the effect of turmeric (Curcuma linga Linn.) etil asetat fraction ointment in wound healing of hiperglicemic mice (Mus musculus albinus). Thirty mice were infected with 40 mg/kgbw of streptozotocin to induced hiperglicemic. Mice were divided into three groups, which were negative control without treatment, positive control was treated with the comersil ointment and the group with the etil asetat turmeric rhizomes fraction ointment treatment. Mice were wounded by scalpel blade on the their dorsoanterior skin of mice around 1.5 cm. The pathology-anatomy of the wound healing procces were observed everyday with wound size, wound colour, wound exudation, and scab formation as the parameter. The histopathology lesion were observed on the 2nd, 4th, 7th, 14th, and 21th days after skin incision. The parameter on the histopathology observation are number of polymorfonuclear cell (neutrofil), macrophag, neovascullary formation, the precentation of wound reepitelization and the percentation of collagen connective tissue. The histopathology observation of etil asetat turmeric rhizomes fraction ointment had anti inflamantory activity as well as neovascularization and reepithelization were faster than the other groups.
Keyword: 

Judul: Perancangan jalur interpretasi wisata sejarah kawasan kota tua Jakarta
Abstrak: Tapak perancangan berupa jalur interpretasi yang terletak di dalam wilayah administrasi kota Jakarta Barat dan melalui Jl. Stasiun, Jl. Pintu Besar Selatan dan Utara, Jl. Kali Besar timur dan barat, Jl. Cengkeh, Jl. Pos, dan Jl. Lada. Aksesibilitas menuju tapak mudah dengan berbagai alternatif sarana transportasi. Tata guna lahan kawasan 78% terdiri dari perkantoran perdagangan.
Keyword: