Judul: Aktivitas Antioksidan Nanokurkuminoid Temulawak Lokal Ciemas Pada Tikus Sprague-Dawley Betina
Abstrak: Java turmeric (Curcuma xanthorrhiza) is a typical Indonesian plants that have antioxidant activity. Clinical testing showed that curcumin safe at high doses (12 g/day) but has low bioavailability. Delivery systems by making of solid lipid nanoparticles made to improve bioavailability of curcuminoids. This study aims to measure antioxidant activity of nanocurcuminoid coated solid lipid in female rat induced by CCl4. Analysis of antioxidant activity by measuring Malondialdehyde (MDA) levels and activity of superoxide dismutase (SOD), gluthatione peroxidase (GPX) and peroxidase (POX). Nanocurcuminoids size that obtained was 114.4±33.8 nm with polydispersity index 0.218 and adsorption efficiency 79%. The results showed that administration of nanokurkuminoid dose of 1500 mg/kg in female rats induced by CCl4 were able to reduce levels of MDA (4.34 nmol/mL) and increasing the activity of SOD (64.70 %), GPx (3208.02 mU/mL) and POX (3.13 mU/mL). These results indicate nanokurkuminoid have antioxidant activity.
Keyword: SLN., nanocurcuminoid, female sprague-dawley, CCl4, antioxidant

Judul: Status Antioksidan Tikus Sprague-Dawley Betina dengan Pemberian Nanopartikel Kurkuminoid Temulawak Balittro
Abstrak: Curcuma (Curcuma xanthorrhiza) is an Indonesian herbs plant with antioxidant activity. This research aimed to measure the increasing of curcuminoids bioavaibility through the efectivity of nanoparticle curcuminoids as antioxidant for carbon tetrachloride (CCl4) induced rats. Nanoparticle curcuminoids was produced by homogenization-ultrasonication method showed results particle size of curcuminoids nanoparticle was 141.85±38.82 nm with polidispersity index was 0.233 and entrapment efficiency was 71%. During the treatment, rat’s body weight was increased. Clinical symptoms of rats (behavior and feces) was normal. Nanoparticle curcuminoids can decrease malondialdehide concentrations and increase peroxide, glutation peroxide, and superoxide dismutase activity.
Keyword: curcuma., solid lipid nanoparticle, curcuminoid, antioxidant

Judul: Hamiltonian formulation for linear waves motion in two layers fluid
Abstrak: The surface wave could be considered as a wave that separates two fluids, namely water and air. Based on this assumption, it is introduced the interfacial wave, a wave between two layers of fluid with different density. The formulation of interfacial waves motion begins with deriving the base equation of irrotational ideal fluid. Furthermore, according to irrotational fluid assumption, the base equation can be stated in velocity potential. In this derivation, the fluids domain is assumed to be restricted by rigid lid boundary conditions, both at the upper and lower limit. Therefore, the interfacial waves motion can be explained in a hamiltonian formulation. In the hamiltonian formulation, total energy is defined as the sum of kinetic and potential energy. The hamiltonian system is obtained from reduction of kinetic energy by using the Dirichlet Neumann Operator. The resulted kinetic energy equation is nonlinear. Therefore, this form is linearized by first part of the Taylor expansion. This linearization gives a dispersion relation of linear wave. Based on this dispersion relation, the phase speed of the linear wave depends on the density ratio of the two layers fluid.
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