Judul: Total Fenolik,  Flavonoid, dan Inhibisi Lipase Pankreas Ekstrak Kulit Buah Nangka (Artocarpus  Heterophyllus Lam.)
Abstrak: Obesitas berhubungan dengan penumpukan lemak di dalam tubuh disimpan dalam bentuk trigliserida. Obesitas dapat dicegah dengan menginhibisi enzim lipase menggunakan senyawa yang berasal dari golongan flavonoid dan fenolik. Kulit buah nangka diketahui memiliki kandungan total fenolik empat kali lebih banyak dibandingkan dengan bagian biji dan daging buah. Oleh karena itu, potensi ekstrak kulit buah nangka sebagai inhibitor lipase perlu dikaji lebih lanjut. Penelitian ini bertujuan menentukan kadar total fenolik, kadar total flavonoid, serta daya inhibisi lipase pankreas oleh ekstrak kulit buah nangka dewasa dan muda secara in vitro. Metode yang digunakan pada penelitian ini yaitu ekstraksi, analisis total fenolik dan flavonoid, serta uji inhibisi lipase. Hasil penelitian menunjukkan bahwa kulit buah nangka muda memiliki total fenolik dan flavonoid serta persen inhibisi lipase yang lebih tinggi dibandinkan kulit buah nangka dewasa, yaitu berturut-turut sebesar 242,50 ± 5,20 mg EAG/g bobot kering, 19,59 ± 0,09 mg EK/g bobot kering, dan 47,81 ± 1,79%. Berdasarkan penelitian yang telah dilakukan, kulit buah nangka muda lebih potensial sebagai kandidat inhibitor lipase pankreas., Obesity is related to the accumulation of fat in the body stored as triglycerides. Obesity can be prevented by inhibiting the lipase enzyme using the compounds from the phenolic and flavonoid groups. Jackfruit peel extract known to have total phenolic and flavonoid four times higher than the seed and pulp part. Therefore, the potential of jackfruit peel extract as pancreatic lipase inhibitor sould be studied further. This research aimed to determine the total phenolic, total flavonoid, and pancreatic lipase inhibition by young and mature jackfruit peel extract in vitro. The methods that has been used in this research are extraction, total phenolic content determination, total flavonoid content determination, and pancreatic lipase inhibition. The result of this research shows that young jackfruit peel extract has higher total phenolic content, total flavonoid content, and pancreatic lipase inhibition than mature jackfruit peel extract with the value of 242,50 ± 5,20 mg GAE/g dry weight, 19,59 ± 0,09 mg QE/g dry weight, and 47,81 ± 1,79% respectively. Based on the research that has been conducted, young jackfruit peel has more potential as pancreatic lipase inhibitor than mature jackfruit peel.
Keyword: flavonoid, jackfruit, lipase, obesity, phenolic

Judul: Antioxidant Capacity and Inhibition of Pancreatic Lipase Results from In vitro Fractionation of Citronella (Cymbopogon Nardus)
Abstrak: Obesitas memiliki faktor risiko yang tinggi dan dapat ditangani dengan menghambat enzim lipase pankreas. Obesitas memicu stres oksidatif yang dapat dicegah dengan antioksidan oleh senyawa fenolik dan flavonoid. Serai wangi (Cymbopogon nardus) belum diketahui potensi fraksinasinya sebagai inhibitor lipase pankreas secara in vitro. Penelitian ini bertujuan mencari fraksi terbaik pada kadar fenolik dan flavonoid total serta kapasitas antioksidan dan inhibisi lipase pankreas. Serai wangi diekstraksi dengan etanol 70% lalu dilanjutkan fraksinasi bertingkat dengan pelarut n-heksan, kloroform, etil asetat, dan air lalu dihitung rendemennya. Selanjutnya diuji kadar fenolik dan flavonoid total serta kapasitas antioksidan dari metode DPPH dan FRAP, lalu diuji daya inhibisi terhadap lipase pankreas. Hasil penelitian menunjukkan bahwa kadar fenolik total tertinggi terdapat pada fraksi air, kadar flavonoid total pada fraksi kloroform, kapasitas antioksidan metode DPPH dan FRAP pada fraksi etil asetat. Penghambatan lipase pankreas baik ekstrak kasar, fraksi, ataupun orlistat tidak berbeda nyata. Perbedaan kepolaran berpengaruh pada tiap uji karena afinitas yang berbeda terhadap sifat kepolaran, Obesity has a high risk factor and can be treated by inhibiting the pancreatic lipase enzyme. Obesity triggers oxidative stress which can be prevented by antioxidants by phenolic compounds and flavonoids. Citronella (Cymbopogon nardus) has no known fractionation potential as an inhibitor of pancreatic lipase in vitro. This research aimed to find the best fraction for total phenolic and flavonoid levels as well as antioxidant capacity and pancreatic lipase inhibition. Citronella was extracted with 70% ethanol then continued with multilevel fractionation with the solvent n-hexane, chloroform, ethyl acetate and water and then the yield was calculated. Next, total phenolic and flavonoid levels were tested as well as antioxidant capacity from the DPPH and FRAP methods, then the inhibitory power against pancreatic lipase was tested. The results showed that the highest total phenolic content was in the water fraction, total flavonoid content in the chloroform fraction, antioxidant capacity of the DPPH and FRAP methods in the ethyl acetate fraction. Inhibition of pancreatic lipase, whether crude extract, fraction or orlistat, was not significantly different. Differences in polarity affect each test because of different affinities for polar properties.
Keyword: in vitro, serai wangi, lipase pankreas, obesitas

Judul: Implementation of Spatio-Temporal Change Query in Relational Database.
Abstrak: Geographic object changes in various views. Object changes are recorded using a model of static storage. No historical connection between old version data and new version data has been built. For that, a storage model of spatio-temporal queries that can analyze spatio-temporal changes has been developed. The object changes the geometry are grouped according to the taxonomy of Spatio-Temporal Pattern Change. This research has been able to apply the query patterns change including born, expand, merge, contract, split, normal and die. This query based on geometric (area) changes. The implementation of spatio-temporal change queries represents an object changes continuously with easy, change detection is done by comparing two versions of data. Keyword: spatio-temporal change query, spatio-temporal change pattern.
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