Judul: Colon Preneoplastic Inhibition of Azoxymetane and Dextran Sodium Sulfate Induced Mice by Fish Oil as Human Chemoprevention Model.
Abstrak: Kanker kolorektal (KKR) merupakan keganasan yang menduduki urutan keempat tersering di dunia dengan angka kematian mencapai 10%. Di beberapa negara bahkan menjadi nomor dua tersering penyebab kematian karena kanker. Seiring perkembangan jaman, selain terjadi peningkatan jumlah kasus, juga terjadi pergeseran penderita ke usia makin muda. Beberapa studi epidemiologis mengaitkan prevalensi KKR dengan faktor lingkungan di samping genetik. Salah satu faktor yang berperan adalah nutrisi. Belakangan juga dikaitkan dengan terjadinya peradangan di jaringan kolon. Beberapa komponen diet diketahui bersifat antitumor sehingga penelitian akhir-akhir ini berfokus pada kandungan mikronutrien yang memiliki sifat antimutagenik. Marine n-3 fatty acids (MFA) merupakan komponen yang terkandung dalam jumlah banyak pada minyak ikan yang diduga berperan dalam menghambat karsinogenesis kolon., Epidemiological studies of the relationship between dietary fish oil and risk of colorectal cancer have been inconsistent. Fish oil is a substance containing poly-unsaturated fatty acid (PUFA) such as ω-3-eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which play a role in inducing cellular apoptosis and differentiation, as well as inhibiting cell proliferation. Except the nutritional factor, colorectal carcinogenesis is also associated with inflammation that occurs in colorectal.
Keyword: Azoxymethane, b-catenin, COX-2, colon cancer, fish oil, iNOS, inflammation

Judul: Studi Komponen Aktif Temu Lawak terhadap Patogenesis Kanker Kolorektum Jalur Protein Induser dengan Penambatan Molekular
Abstrak: Colorectal cancer is caused by excessive amount of inducible NOS (iNOS) and cyclooxygenase-2 (COX-2) protein in the body. Temu lawak is a plant potential as anticancer. The molecular docking method can be used to determine the activity and efficiency of the temu lawak bioactive compounds, which can inhibit the colorectal cancer through inducer protein iNOS and COX-2 pathway. Based on the molecular docking results of 24 bioactive compounds of temu lawak against 16 proteins in iNOS and COX-2 pathways, the two most potencial anticancer compounds were obtained, demethoxycurcumin and dihydrocurcumin. Both compounds could inhibit colorectal cancer through γ-interferon protein in iNOS pathway and inhibit mitogen activated protein kinase in COX-2 pathway. The experimental parameters used were Gibbs free energy (ΔG), affinity (pKi), inhibition constant (Ki), efficiency, and hydrogen bonding. Based on those parameters, the demethoxycurcumin and dihydrocurcumin were more potencial than simvastatin and rosmaniric acid standards.
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Judul: Rancang Bangun Alat Pengukur Intensitas Hujan Dengan Metode Jungkat-Jungkit Berbasis Sensor Medan Magnet UGN3503.
Abstrak: This research has been done on making rain intensity gauge using a magnetic field sensor UGN3503. Sensor UGN3503 can detect the magnetic field on its surface. The sensor is placed above a seesaw that was inserted magnet. The magnet used is Neodymium magnet is a type of permanent magnet with stongest magnetic field compared to other types of fixed magnetic field magnets. When the seesaw discards rainwater, the distance between sensor and magnet is closer and causing the keluaran voltage of the sensor increases. The keluaran voltage of the sensor is compared with a reference voltage by the comparator so that the sensor keluaran data is in digital form and ready to be processed. As the processing and sending of data used ATmega16 microcontroller, microcontroller take sensor data once every 100 ms and display data to the LCD (Liquid Crystal Display) 16x2. Every 30 minutes the data is processed into the rain intensity is then stored into a computer.
Keyword: rain intensity, seesaw, comparator, microcontroller, sensor UGN3503.