Judul: Perkembangan Status Pembangunan Kabupaten/Kota di Provinsi Banten Berdasarkan Konsep Pembangunan Berkelanjutan
Abstrak: Sustainable development has been defined as economic and social development that meets the needs of the current generation without undermining the ability of future generations to meet their own needs. Paradigm of sustainable development is a balance of economic grown, social equity and ecology preservation. The purposes of this study were: (1) to study the achievement of social, economic and environmental development indicators, (2) to measure and analyze the differences of social, economic and environmental development, and (3) to determine status of development in 2001, 2005, and 2009 of regencies/cities in Banten Province based on sustainable development conceps. The data was analyzed by using quantitative descriptive, Full Permutation Polygon Synthetic Indicator (FPPSI), Villain and Champbell analysis. FPPSI analysis used 10 (ten) social indicators, 7 (seven) economic indicators and 10 (ten) environmental indicators were selected based on the principles of simplicity, objectivity, scope, quantification, measurement, sensitivity, and time limit. The result showed that the status of development did not increase in urban areas (Tangerang City, Cilegon City) and rural areas (Pandeglang Regency, Lebak Regency, Serang Regency) from 2001 to 2009. Tangerang City and Cilegon City had equitable status in 2001, 2005, and 2009. Pandeglang Regency and Serang Regency had ecology preservation status in 2001, 2005, and 2009 while Lebak had ecology preservation status in 2001 and 2005, but it dropped to unsustainable status in 2009. The status of development that increased only in the peri urban area (Tangerang Regency), it had sustainable development status in 2005, but it decreased to equitable status in 2009 as well as in 2001.
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Judul: Kesenjangan Persepsi dan Pemahaman Indikator Pembangunan Berkelanjutan dalam Perencanaan Wilayah di Kota Sukabumi
Abstrak: The purpose of the development is to increase the society prosperity can’t be avoided by the nature resources using: however nature resources exploitation which less attention to the capability and environment support make it’s quality decline. Sustainable development must be put as a need and now and future aspiration. Thus, the human right as economy, social and culture right, and development right is able to assist to make the development concept formula orientation continuity clear. The purpose of sustainable development could be achieved if the development planning has been got by the continuity principle of it, beside it should be understood/comprehended by the whole sides because it will participate both in planning and its application. Sukabumi is one of the city which rate growth of population getting increase. The rate of growth population about 1,31% pe annum, so it should be anticipated because the large of Sukabumi is only 4.800,23 Ha. Although Sukabumi is not too large but the population grow fastest. If there is no wise arrangement it will appear the ecological suicide like worried by Simonds (1986). Thus, the generation needed should be anticipated optimally by consideration the future needed. The continuity and balance city planning should be begun from the same perception and stakeholder or society comprehension in Sukabumi. The research purpose are following: 1) identify the perception and the comrehension of sustainable development principle from stakeholder and society in Sukabumi, 2) identify the sustainable development principle in planning document in Sukabumi, 3) analysis the indicator achievement of sustainable development, 4) analysis if there is an imbalance/gaps or not among the research result 1, 2, and 3. The result of research indicated that there is a perception imbalance and comprehension in indicator of sustainable development not only from stakeholder and society but also in planning document in Sukabumi. Imbalance indicated that it should be a performance increased in improving the actual performance, so that it seems like a feedback for getting better on future. The result of research indicated that the sustainable development principle has not become mainstreaming in planning document in sukabumi. However in Sukabumi there was an indicator achievement of sustainable development conspicuous than others city such as in education, health and water resources theme.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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