Judul: Analisis pengaruh jenis asing invasif acacia nilotica Wild. ex Dell 1813 terhadap pola pergerakan banteng (Bos javanicus d’Alton 1823) di Padang Savana Bekol, Taman Nasional Baluran
Abstrak: Bos javanicus d’Alton 1823 (banteng) is a rare and threatened species in the world. In Indonesia, it was conserve in some place, i.e: Baluran National Park. This research investigated the affected factors and effects of Acacia nilotica Wild ex. Dell 1813 invasion on the pattern of banteng movement in Bekol Savanna, Baluran National Park by built the correlation of conservation variable. The objective of the research is to build a conservation model of banteng. This is done by simulating the dynamic model consists of green forage and the effect of Acacia nilotica invasion to determine the carrying capacity in savanna Bekol. Field research began in August through to October 2005 at Bekol Savanna, Baluran National Park, East Java. A system dynamic approach was used since it has demonstrated its capability as a tool to support management for environmental decision. The model is built using software by Powersim Constructur 2.5 to make a prediction about the future behaviour of banteng conservation system. Results revealed that banteng in Bekol Savanna are responsed of movement space and the growth of Acacia nilotica reduced the movement space and forage productivity of Bekol savanna. Based on the simulated model, it was concluded that Acacia nilotica invasion has changed the structure of banteng habitat this resulted in the decrease population of banteng in Bekol savanna.
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Judul: Studi Autekologi dan pengaruh invasi akasia (Acacia nilotica) (L.) Willd. ex Del. terhadap eksistensi savanadan strategi penanganannya di Tamana Nasional Baluar Banyuwangi Jawa Timur
Abstrak: Tujuan yang ingin dicapai dari penelitian ini adalah untuk: (a). Mengetahui autekologi meliputi; siklus hidup, fenologi, produksi biji, pemancaran biji, dan struktur tagakan A. nilotica di Taman Nasional Baluran, (b). Mengetahui derajat invasi A. nilotica di Taman Nasional Baluran dan upaya yang telah dilakukan), (c). Mengetahui pengaruh invasi A. nilotica terhadap komposisi spesies, Indeks Keanekaragaman Spesies (H'), Indeks Similaritas (IS), asosiasi spesies, biomasa tumbuhan bawah dibandingkan dengan daerah yang belum terinvasi A. nilotica.
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Judul: Pemurnian dan karakterisasi protein inhibitor RNA helikase virus hepatitis C
Abstrak: Hepatitis C virus (HCV) infection is the second most common chronic viral infection in the world with global prevalence. This infection is contribution to chronic hepatitis and liver cirrhosis, often leading to hepatocellular carcinoma. There is no effective drug and vaccine available against HCV. The current standard treatment, a combination of pegylated interferon-α with ribavirin, is limited by its suboptimal response rate in a significant patient population, side effects, and affordability. Therefore, development of effective drug is needed. One approach to find out the candidate of antiviral drug is to discover the inhibitor of enzyme that essential for virus replication, such as RNA helicase. Streptomyces chartreusis 5-095 produce the inhibitor of HCV RNA helicase. The aim of this study was to purify the protein inhibitor which has inhibition activity against ATPase activity of RNA helicase HCV from S. chartreusis 5-095. The supernatant of culture S. chartreusis 5-095 exhibited high inhibiton activity against ATPase activity of RNA helicase HCV (approximately 72%) at 10 days of incubation. The extracellular protein inhibitor was partially purified by procedures of precipitation with ammonium sulfate to 65% saturation and gel filtration (Sephadex G50) using methanol water solution (4:6) as an eluen. The purity of protein inhibitor was monitored by SDS PAGE. The protein inhibitor showed a relative molecular mass were estimated to be 14 kDa and increased the purity 23,08 fold than those of the crude protein. The specific activity and IC50 after purification were 13,1338 U/mg and 0,0767 mg/mL, respectively. The activity of purified protein inhibitor showed its stability over pH range from 5-8 and optimum at pH 7,4. The inhibition activity showed its stability up to 70% at temperature 100 oC. The purified protein inhibitor relatively stable its activity at storage in the range of -20 oC to room temperature for 35 days.
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