Judul: The effect of extract of Curcuma xanthorrhiza Roxb on Oxidative Stress and Physical Fitness of Athletes.
Abstrak: The negative impact of heavy physical exercise can increase the formation of free radicals. The imbalance between the number of free radicals formed in the body and the natural antioxidant capacity of the body 's ability can cause oxidative stress. Oxidative stress of exercise can affect a physical fitness of athletes. Curcuma xanthorrhiza Roxb is known as a traditional medicine in the community. Curcuma xanthorrhiza Roxb has a potential of antioxidant. Some studies suggest curcumin content of Curcuma xanthorrhiza Roxb has a protective effect on stress oxidative damage and improving physical fitness oksidasif. Therefore the aims of this study was to examine the effect of Curcuma xanthorrhiza Roxb extract supplementation to prevent oxidative stress and improve physical fitness in athletes. Therefore the aims of this study was to examine the effect of Curcuma xanthorrhiza Roxb extract supplementation to prevent oxidative stress and improve physical fitness in athletes. The study design used was a double-blind randomized controlled trial. A total 35 football athletes of PPLP (Student Training and Education Center) Salatiga, Central Java were enrolled. We grouped into 5 treatments, namely group I : placebo, group II : supplementation of Curcuma xanthorrhiza Roxb extract contains curcumin (TECC) 250 mg/day, group III : TECC 500 mg/day, group IV: TECC 750 mg/day, group V: multivitamin and mineral (MVM with beta carotene 5000 UI, Vitamin E 200 UI, Vitamin C 500 mg, Zn 15 mg, selenium 50 mcg), group V: placebo capsules per day. Capsules had been given for 21 days. The results showed the extract Curcuma xanthorrhiza Roxb were 27.19 % curcumin content with 1.02 % rendement. The extract Curcuma xanthorrhiza Roxb had antioxidant activity of 87.01 ppm classified as an active and potentially good natural antioxidant. Before the intervention, the mean MDA levels were 953.65±355.76 ppm. After the intervention the mean MDA levels all of groups decreased, except for the placebo group. MDA levels of placebo group increased of 104.36±207.07 ppm. The highest decline of MDA levels found in TECC 750 mg was 243.49±170.18 ppm. Having tested with the paired t test, no differences in levels of MDA before and after the TECC 750 mg (p<0.05), but the other treatments did not differ significantly (p>0.05). Ancova test results showed that the decrease in MDA levels (adjusted) after intervention before the intervention affected the levels of MDA, SOD and variations of treatment (p<0.05), but other variables the effect is not significant (p>0.05). LSD post-hoc test showed that the average reduction in MDA levels (adjusted) after the intervention was significantly (p<0.05) higher in the 750 mg group compared to the group TECC 500 mg and MVM, although the placebo group and 250 mg did not differ TECC significantly (p>0.05). Mean lactic acid levels before intervention was 3.44±0.73 mmol/L. After the intervention the mean lactic acid levels are increased in order placebo and TECC 250 mg respectively of 0.30±0.69 mmol/L and 0.24±0.30 mmol/L, while the group that experienced a decrease in the order is TECC 750 mg, MVM and TECC 500 mg amounted to 0.80±0.73 mmol/L, 0.40±1.34 mmol/L, and 0.04 ± 0.55 mmol/L. Paired t test on
Keyword: athlete, Curcuma xanthorrhiza Roxb, physical fitness, oxidative stress