Judul: Clinical Profile of Pregnant Cattle Frisien Holstein After Giving Avian Influenza H5N1 Vaccine
Abstrak: Penelitian ini bertujuan untuk mengamati profil klinis induk sapi perah Friesian Holstein (FH) bunting yang divaksin dengan vaksin Avian Influenza H5N1 melalui pengamatan suhu tubuh, frekuensi respirasi dan pulsus. Sebanyak sembilan ekor induk sapi Friesian Holstein (FH) bunting trimester akhir dibagi ke dalam tiga kelompok, yaitu kelompok kontrol (3 ekor, tidak diberi imunomodulator, antigen AI H5N1 dan vaksin AI H5N1 inaktif), kelompok A (3 ekor, tidak diberi imunomodulator, diberi antigen AI H5N1, dan divaksin AI H5N1 inaktif), dan kelompok B (3 ekor, diberi imunomodulator, antigen anti AI H5N1, dan vaksin AI H5N1 inaktif). Induk sapi diberikan imunomodulator dengan rute oral selama tiga hari berturut-turut sebelum vaksinasi dengan dosis 0,1 ml/kgBB. Imunomodulator yang digunakan berjenis polipeptida ribonukleotida. Setelah itu induk sapi kelompok A dan B disuntik dengan antigen (Ag) H5N1 in-aktif tanpa adjuvan secara intra-vena selama tiga hari berturut-turut dengan dosis 104 HAU/ekor. Selanjutnya induk sapi A dan B divaksin menggunakan vaksin AI H5N1 in-aktif komersial sebanyak 5 dosis unggas/ekor secara subkutan. Vaksin diberikan sebanyak tiga kali, masingmasing dengan interval waktu antar vaksinasi dua minggu. Parameter pemeriksaan fisik yang diamati meliputi suhu tubuh, frekuensi pulsus dan frekuensi respirasi. Pemeriksaan fisik dilakukan sebelum vaksinasi pertama, 3 hari berturut-turut setelah vaksinasi pertama, kedua dan ketiga (hasil angkaangka). Hasil pemeriksaan suhu tubuh, frekuensi respirasi dan pulsus kelompok A dan B pada vaksinasi I, II, dan III masih didalam kisaran normal. Pemberian vaksin H5N1 inaktif pada induk sapi bunting Friesian Holstein tidak berpengaruh negatif terhadap status kesehatan hewan tersebut., This study aims to observe the clinical profile of Friesian Holstein (FH) pregnant dairy cows vaccinated with Avian Influenza H5N1 vaccine through observations of body temperature, respiration frequency and pulsus. A total of nine final trimester pregnant Friesian Holstein (FH) cows were divided into three groups, namely the control group (3 cows, not given immunomodulators, AI H5N1 antigen and inactive H5N1 AI vaccine), group A (3 cows, not given immunomodulators, were given AI H5N1 antigens, and inactivated AI H5N1 vaccines), and group B (3 animals, were given immunomodulators, H5N1 anti AI antigens, and inactivated AI H5N1 vaccines). Cows were given immunomodulators by oral route for three consecutive days before vaccination at a dose of 0.1 ml/kgBB. The immunomodulator used is a ribonucleotide polypeptide. After that, cows in groups A and B were injected with in-active H5N1 antigen (Ag) without adjuvant intravenously for three consecutive days at a dose of 104 HAU/head. Furthermore, cows A and B were vaccinated using the commercial in-active H5N1 AI vaccine as many as 5 doses of poultry/head subcutaneously. The vaccine is given three times, each with a time interval between vaccinations of two weeks. Physical examination parameters observed included body temperature, pulse rate and respiration rate. Physical examination was carried out before the first vaccination, 3 consecutive days after the first, second and third vaccinations (results figures). The results of examinations of body temperature, respiration frequency and pulses of groups A and B in vaccinations I, II, and III were still in the normal range. The conclusion of this study was that the administration of inactivated H5N1 vaccine to pregnant Friesian Holstein cows
Keyword: Avian Influenza, imunomodulator, Frisien Holstein cow, H5N1 vaccination