Judul: Aktivitas antihiperglikemia fraksi air buah makasar (Brucea javanica (L.) Merr) pada tikus yang diinduksi aloksan
Abstrak: Brucea fruit (Brucea javanica (L.) Merr) was known to have a potential antidiabetic activity. This research was aimed to determine antihyperglycemic activity of aqueous fraction from ethanolic extract of brucea fruit in alloxan induced rats. Aqueous fraction of ethanolic extract brucea fruit obtained by maseration using ethanol 95%, which then separated using funnel separator with mixed solution of hexane, methanol, and water (5:9:1) and chloroform:water (1:1). Twenty four rats divided into 6 groups. In the process of raising the blood glucose concentration, one of normal group induced by NaCl 0.9% and the other five treatment groups induced by alloxan (150 mg/kg BW). Afterwards, in the treatment process, normal group and negative control administered by aquadest, positive control administered by glibenclamid (0.25 mg/kg BW), and three other groups administered by aqueous fraction of ethanolic extract brucea fruit in dosage 0.25, 25, and 50 mg/kg BW. Blood glucose concentration of the fasting rats measured at day 0, 3,7,11, and 15. Aqueous fraction from ethanolic extract of brucea fruit contained 3.71% in yield. The result showed that aqueous fraction from ethanolic extract of brucea fruit in dosage 0.25, 25, dan 50 mg/kg BW decreased the blood glucose concentration as many 37.64%, 37.43%, and 60.82% respectively. Aqueous fraction of brucea fruit wich is extracted by ethanol in dosage 50 mg/kg BW has higher activity than glibenclamid in dosage 0.25 mg/kg BW (45.53%).
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Judul: Potensi Buah Makasar (Brucea javanica (L.) Merr) sebagai Inhibitor Enzim α-Glukosidae
Abstrak: Brucea fruit is one Indonesian medicine plants which rich in advantages. Empirically, brucea fruit can decrease blood glucose concentration for patient of diabetes mellitus. Water fraction of brucea fruit extract have been observed to determine its ability as antidiabetic would be compared with acarbose as positive control in same concentration (1%). Antidiabetic test in water and hexane fraction of brucea fruit extract use α-glucosidase inhibition method. Antidiabetic activity has been measured by formation of p-nitrophenol from enzymatic reaction of nitrophenil--D-glucopyranose (p-NPG) which is catalyze by α-glucosidase enzyme. The formation of p-nitrophenol was measured by spectrophotometer at λ=400 nm. Phytochemistry test showed that water fraction contains alkaloid and flavonoid, whereas hexane fraction only contain alkaloid. The result of this research is water fraction and hexane of brucea fruit (Brucea javanica (L.) Merr) at concentration 1% (b/v) can inhibit α-glucosidase enzyme activity 14.32% and 12.76%, whereas Acarbose as positive control can inhibit α-glucosidase enzyme activity 81.15%.
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Judul: Pengembangan Prototype Platform Rekrutmen Tenaga Pendidik: Teachy Path
Abstrak: Proses perekrutan calon tenaga pendidik menjadi faktor utama penentu penyerapan tenaga pendidik yang berkualitas dan berkompetensi sesuai standar kelayakan. Namun dalam pelaksanaannya masih ditemukan penghambat terwujudnya proses perekrutan seperti yang diharapkan dari pihak rekruter maupun pihak tenaga pendidik. Tujuan penelitian ini adalah mengidentifikasi permasalahan yang dihadapi pihak rekruter dan pihak tenaga pendidik dalam proses rekrutmen, merumuskan model bisnis yang tepat, serta merancang platform sebagai solusi permasalahan. Metode yang digunakan pada penelitian ini adalah design thinking dan lean startup dengan alat analisis berupa empathy map, lean canvas, dan USE Questionnaire. Hasil penelitian menunjukkan baik rekruter maupun tenaga pendidik masih mengalami permasalahan dalam proses rekrutmen. Setelah dilakukan dua kali iterasi, model bisnis Teachy Path yang merupakan platform rekrutmen tenaga pendidik berupa multi-sided platform sangat layak dikembangkan menjadi solusi permasalahan.
Keyword: design thinking, lean startup, multi-sided platform, rekrutmen, tenaga pendidik