Judul: Peningkatan mutu dan penerapan cara produksi pangan yang baikpada industri rumah tangga minuman temulawak instan di Desa Benteng, Ciampea, Bogor
Abstrak: This research was consisted of 5 steps i.e. to study the characteristic of Home Industrial Food Product (HIFP) of temulawak instant drink, to improve formulation and process of temulawak instant drink, to determine chemical characteristic of the product, certification of temulawak instant drink product of home industrial scale, and analyses of business feasibility. The first step was to determine the condition of Home industrial temulawak instant drink. The data of this step was used to improve formula and process to obtain standard formula. Besides, determination of Standarad Operating Procedure of home industrial of temulawak instant drink was carried out as further step of the improvement of formula and production process. The second step of this research was to analyse the chemical characteristic of the standard formula’s product using proximat analyses. The propose of certification of Home Industrial Food Product (HIFP) to was carried out as the fourth step. Finally, business feasibility analyses on home industrial scale was done to determine whether this business are feasible or not. Formula III (the ratio temulawak and sugar amount 1:2) was chosen as the most acceptable formula since it showed highest preference level as result of organoleptic test. This formula also had the shortest rehydration period and highest yield. The chemical and phsycal properties of instant temulawak are 1,06% of water content; 2,84% of ash content; 3,51% of fat content; 2,07% of protein content; 90,53% of carbohydrat content; and 33,09% of total sugar with L= +52,53; a= +3,29; b= +29,16 representating the color. This instant Coro has 0,428% of dissoluble part and 28 second for rehydration time. Home industrial of temulawak instant drink considered to be sufficient in GMP application and has acquired HIFP certificate with serial number of6123201021009 from governmental health department. The feasibility study based on investment criteria showed the production of instant temulawak was feasible to be done.
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Judul: Development and Implementation of Good Jamu Gendong Production Practice to Improve Its Microbiological Quality and Safety
Abstrak: Jamu gendong is a traditional Indonesian herbal beverage that can be considered as functional beverages because of their flavonoid content and essential oils from its herbs and spices. Although they are believed to help maintain good health, they are often considered low in quality and safety. This study aims to assess the microbiological quality of jamu gendong from two jamu gendong producers in Bogor using parameters such as microbiological quality of utensils, workers, processing and product to be used in developing a Good Jamu Gendong Production Practice (GJGPP) guideline for a home industry scale and implement it to those jamu gendong producers. This study consist of evaluation of production steps through observation, development of GJGPP guidelines by taking into considerations of Good Food Production Practice for home industry issued by The Indonesian National Agency for Drug and Food Control, implement the GJGPP guideline and evaluation of microbiological quality (Total Plate Count, Salmonella sp. and Staphylococcus sp. analysis) of the investigated products (beras kencur and temulawak extract), utensils (bottles) and environment (air sanitation) before and after implementation. The results obtained from this study showed that the number of microorganism in beras kencur and temulawak extract exceeded the maximum recommended standards and that its production did not meet the standard requirements for good production practices. Almost all standard of good production practices was violated. Factors influencing the high microbial content include : poor production practices (poor rhizome sortation and washing) , lack of hygienic practices during processing, no standardized processing procedures and no written standardized formula for both temulawak and beras kencur extract. and are also supported by the characteristic of the product that has a high pH, availability of nutrients, water activity and temperature (processing and storage), but also was inhibited by antimicrobial content. After implementation of the GJGPP, investigated samples show a decrease in microbial load. Product microbial load succeed to decrease near enough the maximum recommended standards and are negative in Salmonella sp. and Staphylococcus sp. Results on air sanitation before and after implementation showed a slight decrease, therefore environmental hygiene practices was not as critical as personnel hygiene. Application of good production practices in jamu gendong production has improved jamu gendong microbiological quality and safety
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Judul: Differential Leukocytes in Mice (Mus muscullus) after Amyloid Beta Aβ40 and Aβ42 Immunization as a Marker of Alzheimer’s Disease.
Abstrak: Alzheimer merupakan penyakit neurodegeneratif yang bersifat irreversibel dan progresif yang terkait dengan perubahan sel-sel saraf, sehingga menyebabkan kematian sel otak dan terjadinya demensia. Pengamatan terhadap diferensial leukosit dapat membantu dalam mendiagnosa penyakit ini dengan tepat. Penelitian ini bertujuan mengetahui gambaran diferensial leukosit pada mencit terhadap respon imunisasi amyloid beta Aβ40 dan Aβ42. Penelitian ini menggunakan 22 ekor mencit (Mus muscullus) Balb/c jantan dan betina dengan berat badan 20-35 gr. Mencit dibagi menjadi tiga kelompok yaitu, kelompok mencit kontrol, kelompok mencit vaksinasi antigen amyloid Aβ40 dan kelompok mencit vaksinasi antigen amyloid beta Aβ42. Sampel darah dimabil melalui vena coccygea sebanyak 0,5 ml setiap mencit. Sampel darah diambil pada hari ke-0, 14 dan 24 setelah diimunisasi. Hasil menunjukkan kelompok mencit yang diimunisasi amyloid beta 40 (Aβ40) dan amyloid beta 42 (Aβ42) menyebabkan peningkatan jumlah limfosit dan neutrofil yang signifikan, sedangkan kelompok mencit kontrol tidak menunjukkan perubahan leukosit yang signifikan. Berdasarkan hasil pengamatan dapat disimpulkan bahwa pemberian imunisasi antigen amyloid beta Aβ40 dan Aβ42 pada mencit tidak memengaruhi jumlah basofil, eosinofil, neutrofil batang serta monosit., Alzheimer's is an irreversible and progressive neurodegenerative disease associated with changes in nerve cells, leading to brain cell death and dementia. Observation of differential leukocytes can help in diagnosing the disease precisely. This study aims to find out the differential picture of leukocytes in mice against amyloid beta Aβ40 and Aβ42 immunization responses. This study used 22 mice (Mus muscullus) Balb / c male and female with a weight of 20-35 grams. Mice were divided into three groups, namely, the control mice group, the Aβ40 amyloid antigen vaccination mice group and the Aβ42 amyloid beta antigen vaccination mice group. Blood samples are taken through the coccygea vein as much as 0.5 ml per mice. Blood samples are taken on days 0, 14 and 24 after immunization. Results showed the mice group immunized amyloid beta 40 (Aβ40) and amyloid beta 42 (Aβ42) caused a significant increase in lymphocyte and neutrophil counts, while the control mice group showed no significant leukocyte changes. Based on the observations, it can be concluded that immunization of amyloid beta Aβ40 and Aβ42 antigens on mice does not affect the number of basophils, eosinophils, bar neutrophils and monocytes.
Keyword: Alzheimer, Diferensial leukosit, Amyloid beta, Mencit, Alzheimer's, differential leukocytes, amyloid beta, mice