Judul: Implementation of  Good Governance Principles t in the management of Ngelanggeran Tourism Village, Gunung Kidul, Yogyakarta
Abstrak: Penerapan prinsip tata kelola yang baik merupakan salah satu pendekatan pengelolaan wisata berkelanjutan. Prinsip tata kelola yang baik dalam konteks pariwisata meliputi partisipasi, akuntabilitas, dan transparansi. Penelitian ini bertujuan untuk menganalisis implementasi dan faktor-faktor yang memengaruhi penerapan prinsip-prinsip good governance di Desa Wisata Nglanggeran. Metode yang digunakan dalam penelitian ini adalah survey rumah tangga yang disebar ke lima dusun dengan stratified random sampling dan wawancara semi struktural dengan Kelompok Sadar Wisata (Pokdarwis), perangkat desa dan perwakilan masyarakat. Penerapan prinsip disajikan secara deskriptif kuantitatif dengan menggunakan metode analisis tematik. Faktor-faktor penerapan prinsip-prinsip dirumuskan dengan menggunakan metode triangulasi. Kajian ini menunjukkan bahwa penerapan prinsip good governance dari ketiga prinsip tersebut telah dilaksanakan di Desa Nglanggeran, meskipun implementasinya belum maksimal. Ada beberapa faktor yang memengaruhi penerapan prinsip tersebut, yaitu peran gender dalam masyarakat, jarak dari rumah ke pusat kegiatan wisata, keterampilan individu, mekanisme keterlibatan individu dan ketersediaan waktu., The application of the principles of good governance is an approach to managing tourism sustainability. The principles of good governance in the context of tourism are participation, accountability and transparency. This study aimed to analyze the implementation and the factors that influence the application of the principles in the Nglanggeran Tourism Village. The method used in this study were household survey, which was distributed to five hamlets using stratified random sampling, and semi-structured interviews with Tourism Awareness Group (Pokdarwis), village officials, and community representatives. The application of the principles was presented in a quantitative descriptive manner using thematic analysis methods. The factors for applying the principles were formulated using the triangulation method. This study showed that the three principles of good governance had been applied in Nglanggeran Village, although not maximal. There were several factors that influence the application of these principles, namely gender roles in society, distance from home to the center of tourism activities, individual skills, mechanisms for individual involvement and time availability.
Keyword: pariwisata berkelanjutan, prinsip, tata kelola, governance, principles, sustainable tourism

Judul: Collaboratove Governance in the Development of Indigenous Ecotourism in East Citorek Village, Kasepuhan Citorek
Abstrak: Ekowisata adat merupakan konsep wisata alam yang juga menawarkan pengalaman budaya yang khas. Namun, terdapat beragam tantangan dalam pengembangannya karena menyangkut pemanfaatan tempat hidup dan nilai budaya masyarakat adat. Oleh karena itu, model tata kelola dengan partisipasi aktif stakeholder multi-sektor dan multi-level termasuk kelembagaan adat menjadi penting. Ekowisata dalam konsepnya berusaha memastikan pengembangan yang berkelanjutan secara lingkungan, layak secara ekonomi dan bertanggung jawab secara sosial budaya. Penelitian ini bertujuan mengidentifikasi mekanisme kerja stakeholder dan model tata kelola, serta menganalisis hubungan antara tingkat collaborative governance dengan dimensi keberlanjutan pada pengembangan ekowisata adat di Kasepuhan Citorek, Desa Citorek Timur. Pendekatan yang digunakan adalah kuantitatif melalui kuesioner dan kualitatif melalui wawancara mendalam. Hasil penelitian menunjukkan bahwa terdapat hubungan positif antara tingkat collaborative governance dengan tingkat keberlanjutan ekologi, sosial-budaya, ekonomi, dan kelembagaan dalam pengembangan ekowisata adat., Indigenous ecotourism is a natural tourism concept that also offers unique cultural experiences. However, there are various challenges in its development because it concerns the use of living places and cultural values of indigenous communities. Therefore, a governance model with the active participation of multi-sector and multi-level stakeholders including indgenous institutions is important. Ecotourism in its concept seeks to ensure development that is environmentally sustainable, economically viable and socially and culturally responsible. This research aims to identify stakeholder working mechanisms and governance model, and analyze the relationship between the level of collaborative governance and the dimensions of sustainability in the development of indigenous ecotourism in Kasepuhan Citorek, East Citorek Village. The approach used is a quantitative through questionnaires and a qualitative through in-depth interviews. The research results show that there is a strong relationship between the level of collaborative governance and the level of ecological, socio-cultural, economic and institutional sustainability in the development of indigenous ecotourism.
Keyword: keberlanjutan, stakeholder, collaboratove governance, ekowisata adat

Judul: Pemeriksaan Histopatologi Cardiotoxicity Yang Diinduksi Jantung Pada Tikus Yang Diobati Dengan Doxorubicin Dan Cyclophosphamide
Abstrak: Cyclophosphamide is classified as an alkylating agent, whereas doxorubicin belongs to the anthracycline class, both of which are commonly employed chemotherapy drugs. Previous research has established that the choice of chemotherapy medications significantly impacts the development of cardiotoxicity. Myocarditis, characterized by inflammation of the myocardium, adversely affects the heart's electrical system and muscle cells, leading to impaired blood pumping capabilities. Consequently, the heart becomes more susceptible to clot formation, ultimately resulting in cardiac failure. The objective of this study was to observe, compare, and describe the lesions induced by two distinct chemotherapeutic drugs in rat models, utilizing normal heart tissue as the control. Routine Hematoxyline- Eosin (HE) staining was employed for histopathological assessments. Subsequently, the histopathological images were analysed descriptively and statistically using appropriate methods. The findings revealed that the diameter of myocardial cells remained unaffected by both doxorubicin and cyclophosphamide treatments, in comparison to the normal-control group. Histopathologically, both doxorubicin- and cyclophosphamide-treated groups exhibited multiple necrotic myocardial cells and focal infiltrations of mononuclear cells, predominantly macrophages and lymphocytes, between the myocardial cells. Furthermore, distinct pathological differences were observed between the doxorubicin- and cyclophosphamide-treated groups, with cyclophosphamide toxicity additionally presenting with pericarditis alongside myocarditis, in contrast to doxorubicin toxicity. In conclusion, these results demonstrate that the type of chemotherapeutic drugs employed leads to variations in the resulting lesions.
Keyword: Cardiotoxicity, chemotherapy, cyclophosphamide, doxorubicin, myocarditis