Judul: Studi Kasus Tumor Kelenjar Hipofise pada Tikus
Abstrak: The development of pituitary tumors in small rodents is a grievous and irreversible pathological condition. Detecting pituitary tumors is difficult, frequently resulting in a late-stage diagnosis or even post-mortem detection. Notably, there is a lack of literature on this tumor in Indonesia. This study aims to enhance our comprehension of pituitary tumors in rats by investigating their pathomorphological characteristics. The research methodology entails obtaining organ samples, such as the pituitary gland, kidney, and cerebellum, from euthanized rats afflicted with pituitary tumors. Grossly, the tumor looks like a small mass at the base of the brain, measuring 0.5 cm in size. Subsequently, histopathological preparations are performed using hematoxylin-eosin (HE) staining, enabling examination under a light microscope. Parameters evaluated include the growth patterns of proliferative lesions, cellular pleomorphism, and atypia. Histological findings indicate that the pituitary gland comprises hyperplastic, chromophobic tumor cells arranged diffusely, displaying anisokaryotic nuclei. Occasionally, mitotic figures have been observed. The absence of kidney and cerebellum abnormalities suggests the absence of tumor metastasis. This pituitary tumor is conclusively classified as a nonfunctional chromophobe adenoma.
Keyword: pituitary tumor, pituitary gland, rat, histopathology

Judul: Studi Kasus: Patologi Anatomi dan Histopatologi Seekor Anjing dengan Tumor Adrenal
Abstrak: Seekor anjing betina lokal berumur 11 tahun dengan anamnese diare berdarah telah dinekropsi di Laboratorium Patologi Veteriner Fakultas Kedokteran Hewan, Institut Pertanian Bogor. Perubahan patologi anatomi saat nekropsi ditemukan ulkus lidah, gastritis ulseratif, enteritis hemoragis, pankreatitis nekrotikan, perdarahan endokardium, hipertrofi ventrikel kiri dan dilatasi ventrikel kanan jantung, pneumoni disertai emfisema paru, tumor adrenal kiri serta nefritis interstitialis kronis. Hasil pemeriksaan histopatologi menunjukkan stomatitis' ulseratif lidah, gastritis ulseratif, enteritis hemoragis, pankreatitis nekrotikan, pembendungan serta degenerasi lemak hati, endokarditis dan miokarditis, pneumoni disertai emfisema dan antrakosis, hiperplasia tiroid, tumor korteks adrenal kiri, hemosiderosis limpa, nefritis interstitiaIis kronis,dan korpus luteum persisten. Studi kasus ini mengkaji hubungan antara kejadian tumor adrenal dengan timbulnya lesio dipelbagai organ dan dikaitkan dengan patogenesa penyebab kematiannya. Tumor korteks adrenal menyebabkan diproduksinya mineralokortikoid secara berlebihan, sehingga dalam waktu yang lama menyebabkan kerusakan ginjal. Kerusakan ginjal kronis menyebabkan uremia, yang selanjutnya menyebabkan kerusakan organ-organ pencernaan seperti stomatitis ulseratif, gastritis ulseratif dan enteritis hemoragis. Selain itu, gagal ginjaI menyebabkan tekanan darah meningkat, dan apabila keadaan ini terus berlangsung akan menyebabkan kegagalan jantung yang akhirnya menimbulkan pembendungan organ visera. Tumor korteks adrenal juga menghasilkan glukokortikoid dan estrogen yang berlebihan, sehingga pada kasus ini ditemukan degenerasi lemaIc haji, korpus luteum persisten dan hiperplasia tiroid.
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Judul: Optimasi Penjadwalan Armada Pesawat Terbang
Abstrak: One of the common issues faced by airline companies relies on fulfilling passenger demands for Origin-Destination (O-D) routes using all fleet types. This paper presents an optimization model to determine fleet assignment for each flight route in order to minimize total costs. The total costs consist of the operating cost and passenger spill cost. The model is considered as an integer linear programming which is further implemented within the Citilink airlines schedule, and was solved using software Lingo 11.0. The model produced a fleet assignment in order to fulfill demand for all O-Ds with minimum cost.
Keyword: fleet assignment, integer linear programming, optimization