Judul: Gambaran darah mencit (Mus musculus albinus) pada proses persembuhan luka yang diberi salep fraksi etil asetat dan fraksi air rimpang kunyit (Curcuma longa Linn.)
Abstrak: Penelitian ini bertujuan mengetahui aktivitas pemberian sediaan topikal dalam bentulc salep dari ekstrak rimpang kunyit (Curcuma longa Linn.) terhadap gambaran darah dalam proses persembuhan luka pada mencit putih (Mus nzusculus albinus). Sebanyak 40 ekor mencit albino jantan dengan berat 20-40 gram, berumur 2 bulan digunakan dalam penelitian ini. Mencit dibagi menjadi 4 kelompok dengan setiap kelompoknya 10 ekor mencit, yaitu kontrol positif dengan obat komersial yang mengandung neomycin sulfat 5% (K+), kelonlpok kontrol negatif tanpa sediaan (K-), kelolnpok perlakuan dengan fraksi etil asetat rimpang kunyit (PE), dan kelompok perlakuan dengan fraksi air rimpang kunyit (PA). Kulit daerah punggung anterior tiap mencit dilukai dengan skalpel sepanjang 11.5 cm. Aplilcasi sediaan salep dilakukan setiap hari sebanyak dua kali sehari selana 21 hari pasca perlukaan. Pengamatan hematologi dilalcukan pada hari ke- 2, 4, 7, 14, dan 21. Hasil uji penapisan fitokomia menunjukan bahwa fraksi etil asetat rimpang kunyit mengandung senyawa-senyawa kimia dari golongan flavonoid dan kuinon, sedangkan fraksi air rimpang kunyit hanya mengandung senyawa kimia dari golongan kuinon. Gambaran darah mencit akibat pemberian salep fraksi etil asetat rinlpang kulyit (PE) memperlihatkan profil yang lebih mendekati kelompok kontrol positif (K+) daripada kelompok mencit yang diberi salep fralcsi air rimpang kunyit (PA). Hal ini terlihat dari profil ganbaran darah hingga akhir pengamatan. Secara umuln sediaan salep rimpang kunyit dengan fraksi etil asetat mempunyai manfaat dalam memba~rtu proses persembuhan luka dibandingkan dengan salep rimpang kunyit dengan fraksi air, sehingga salep rimpang kunyit dengan fraksi etil asetat berpotensi untuk dikembangkan menjadi obat komersial.
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Judul: Pengaruh Pemberian Salep Fraksi Etil Asetat Rimpang Kunyit (Curcuma longa Linn.) terhadap Persembuhan Luka Mencit (Mus musculus albinus) Hiperglikemik
Abstrak: The aim of this research was to know the effect of turmeric (Curcuma linga Linn.) etil asetat fraction ointment in wound healing of hiperglicemic mice (Mus musculus albinus). Thirty mice were infected with 40 mg/kgbw of streptozotocin to induced hiperglicemic. Mice were divided into three groups, which were negative control without treatment, positive control was treated with the comersil ointment and the group with the etil asetat turmeric rhizomes fraction ointment treatment. Mice were wounded by scalpel blade on the their dorsoanterior skin of mice around 1.5 cm. The pathology-anatomy of the wound healing procces were observed everyday with wound size, wound colour, wound exudation, and scab formation as the parameter. The histopathology lesion were observed on the 2nd, 4th, 7th, 14th, and 21th days after skin incision. The parameter on the histopathology observation are number of polymorfonuclear cell (neutrofil), macrophag, neovascullary formation, the precentation of wound reepitelization and the percentation of collagen connective tissue. The histopathology observation of etil asetat turmeric rhizomes fraction ointment had anti inflamantory activity as well as neovascularization and reepithelization were faster than the other groups.
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Judul: Basis of Social Theories for Social Enterprises: Integrative Literature Review
Abstrak: Social enterprise is a hybrid organization aiming to achieve economic and social values that exist as an effective mechanism for creating value in the form of society, economy and environment. The development of social enterprise is considered to have contributed in increasing innovation as well as being a mechanism for ensuring economic development that is in line with social justice. However, the development of theory and study of social enterprise is still lagging behind in practice. The social enterprise conception is a conception that is still considered as a "young term" category in the social sciences and has not shown clear consistency linking social theories to the development of social enterprise. This study aims to identify the basic theories of social enterprise and social theories for social enterprise with used an integrated literature review approach with data sources from Scopus and ProQuest. The results of the study found that socio-economic theory is the basis for social enterprise theory. This study also found the linkages of 7 social theories for social enterprise and the mapping of social theory architecture for social enterprise which is studied on classical and contemporary social theories.
Keyword: integrative literature review, social economic, social enterprise, social theory