Judul: Pemeriksaan Toksikopatologi Efek Pemberian Berbagai Fraksinasi Ekstrak Batang Gatep Pahit (Quassia indica (Gaernt.) Nooteboom) Pada Organ Hati dan Ginjal Mencit (Mus musculus)
Abstrak: The aim of this research was to study the toxicopathology effect of gatep pahit (Q. indica) stem extract fractionation given using various solvents of different polarity (hexane, chloroform, ethyl acetate, and ethanol residue) on mice (Mus musculus) liver and kidney. Twenty five mice (Mus musculus) were divided into five groups. Four groups were given 100 mg/kg BW stem extract fractionation of Q. indica using various different solvent and one group of mice performed as control which received carboxymethocellulose (CMC-Na) 1%. After 1 week of treatment, the mice then were euthanized with over dose of ether. The liver and kidney were taken and fixed in 10% of Buffer Neutral Formalin for 48 hours. The tissue samples were processed to make histopathology slides stained with Hematoxylin Eosin. The tissues were examined under the light microscope. The toxicopathology assay included to count the cells under went necrosis/apoptosis and degeneration. The results revealed that the Q. indica chloroform fraction has the lowest level of damage to hepatocytes while hexane fraction showed the most hepatocytes damaged. The Q. indica hexane fraction caused the less damage in kidney tubular epithelium while the ethyl acetate showed the most epithelium damaged.
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Judul: Histopathological Description of the Liver and Kidney of Mice (Mus musculus) in the Acute Toxicity Test of Mangkokan Leaf  (Nothopanax scutellarium Merr.)
Abstrak: Uji toksisitas merupakan salah satu pengujian yang dilakukan untuk menilai keamanan suatu senyawa kimia. Uji toksisitas akut ini dilakukan untuk menentukan nilai toksisitas akut ekstrak daun mangkokan (Nothopanax scutellarium Merr.) dengan metode Thompson dan Weil serta mendeskripsikan gambaran histopatologi organ hati dan ginjal pada mencit. Penelitian ini menggunakan hewan coba sebanyak 16 ekor mencit dan dibagi menjadi 4 kelompok perlakuan. Kelompok perlakuan diberi suspensi sediaan uji ekstrak daun mangkokan dengan dosis bertingkat sebanyak 3, 6, 12, 24 g/kg bobot badan (BB). Pemberian ekstrak dilakukan secara oral menggunakan sonde lambung dan diberikan dalam dosis tunggal. Mortalitas dan gejala klinis diamati pada 24 jam pertama setelah perlakuan dan dilanjutkan pengamatan selama 6 hari berikutnya. Pengamatan histopatologi dilakukan dengan mengambil organ hati dan ginjal mencit setelah dilakukannya nekropsi. Bobot badan, bobot hati dan ginjal ditimbang dan dianalisis secara statistik dengan one way ANOVA, sedangkan hasil pengamatan histopatologi disajikan secara deskriptif. Hasil penelitian menunjukkan tidak terdapat mencit yang mengalami gejala klinis dan kematian setelah diberikan ekstrak daun mangkokan hingga dosis 24 g/kg BB. Bobot badan dan bobot organ mencit tidak berbeda nyata (p>0.05) antar perlakuan. Pengamatan histopatologi tidak menunjukkan adanya perubahan atau kelainan pada organ hati dan ginjal., Toxicity assay is one of the tests performed to assess the safety of a chemical compound. This acute toxicity test was carried out to determine the acute toxicity value of mangkokan leaf extract (Nothopanax scutellarium Merr.) using the Thompson and Weil method and to describe the histopathological features of the liver and kidneys in mice. This study used 16 mice as experimental animals and divided them into four treatment groups. The treatment group was given a suspension of the mangkokan leaf extract test preparation with graded doses of 3, 6, 12, and 24 g/kg body weight (BB). The extract is administered orally using a gastric tube and given in a single dose. Mortality and clinical symptoms were observed in the first 24 hours after treatment and continued observation for the next six days. For the histopathological assay made by taking the liver and kidneys of mice after necropsy. Body weight, liver, and kidney weights were weighed and statistically analyzed using one-way ANOVA, while the results of the histopathological assay were presented descriptively. The results showed no mice with clinical symptoms and death after being given mangkokan leaf extract up to 24 g/kg BW dose. The body and organ weight of mice were not significantly different (p>0.05) between treatments. The histopathological assay showed not any changes or abnormalities in the liver and kidneys.
Keyword: histopatologi, Nothopanax scutellarium Merr., uji toksisitas akut

Judul: Strategic Fit Value Proposition Produk Wedding Souvenir Du Anyam
Abstrak: Du Anyam adalah perusahaan sosial yang memproduksi produk sustainable wedding souvenir premium yang terbuat dari bahan alami dengan memberdayakan perempuan di pedesaan Indonesia. Du Anyam memiliki rencana pengembangan produk wedding souvenir dalam beberapa tahun ke depan. Namun, produk wedding souvenir mengalami penurunan beberapa tahun sebelum 2021. Penelitian ini ditujukan untuk merumuskan strategic fit pada value proposition produk wedding souvenir Du Anyam. Penelitian ini menggunakan TAM SAM SOM, peta empati, dan value proposition canvas dengan metode kualitatif. Semi-structured in-depth interview dilakukan kepada pihak manajemen Du Anyam serta pelanggan potensial pada bulan Mei hingga Juni 2022. Hasil wawancara dengan pihak manajemen dan pelanggan potensial dipetakan ke dalam value proposition canvas 0 sampai 1. Pengukuran market size menghasilkan 96 pernikahan yang menjadi pangsa pasar produk. Strategic fit berdasarkan prioritas tertinggi pelanggan potensial menghasilkan poin existing, perbaikan, dan pembaruan value proposition. Hasil pencocokan diharapkan dapat menjadi referensi perusahaan dalam pengembangan produk wedding souvenir Du Anyam.
Keyword: market size, perusahaan sosial, peta empati, value proposition canvas