Judul: Potential Active Compound Of White Turmeric (Curcuma  Zedoaria) as PLpro SARS-Cov-2’s Inhibitor by In Silico
Abstrak: SARS-CoV-2 yang menjadi penyebab COVID-19 diketahui mengkode dua protease, yaitu 3CL-Pro (protease utama) dan PLpro (Papain Like protease). PLpro berperan dalam proses pematangan replikasi virus dan dapat menghambat respon imun sel inang melalui penghilangan ubiquitin atau deubiquitinasi (DUBs). Hal ini menjadikan PLpro sebagai target obat yang baik. Kunyit putih (Curcuma zedoaria) merupakan tanaman herbal yang diketahui memiliki berbagai jenis bioaktivitas seperti antikanker dan antimikroba. Namun, belum pernah dilakukan penelitian terkait potensinya sebagai antivirus. Penelitian ini bertujuan menguji potensi senyawa tanaman kunyit putih dalam menghambat aktivitas proteolitik PLpro SARS-CoV-2 yang dimulai dengan analisis bioavaibilitas ligan, validasi dan penambatan molekuler terarah menggunakan YASARA Structure, analisis interaksi ligan-reseptor menggunakan Discovery Studio, dan visualisasi binding pose menggunakan PyMol. Seluruh ligan uji merupakan inhibitor kompetitif. Epicurzerenone merupakan ligan dengan potensi inhibisi terbaik berdasarkan energi ikatan sebesar -4.734 kkal/mol, interaksi, dan sisi aktif pengikatan. Kata kunci : kunyit putih, Papain Like Protease (PLpro), penambatan molekuler, SARS CoV-2., SARS-CoV-2, which causes COVID-19, is known to encode two proteases, namely 3CL-Pro (main protease) and PLpro (Papain Like protease). PLpro plays a role in the maturation process of viral replication and can inhibit host cell immune responses through ubiquitin removal or deubiquitination (DUBs). This makes PLpro a good drug target. White turmeric (Curcuma zedoaria) is an herbal plant that is known to have various types of bioactivity such as anticancer and antimicrobial. However, no research has been conducted regarding its potential as an antiviral. This study aimed to examine the potential of white turmeric plant compounds in inhibiting the proteolytic activity of PLpro SARS-CoV-2 starting with analysis of ligand bioavailability, validation and directed molecular anchoring using YASARA Structure, analysis of ligand-receptor interactions using Discovery Studio, and visualization of binding poses using PyMol. All test ligands were competitive inhibitors. Epicurzerenone is the ligand with the best inhibitory potential based on the binding energy of -4.734 kcal/mol, interactions, and the active binding site. Keywords : molecular docking, Papain-like protease (PLpro), SARS CoV-2, white turmeric.
Keyword: kunyit putih, Papain Like Protease (PLpro), penambatan molekuler, SARS-CoV-2, molecular docking, white  turmeric

Judul: Potensi Senyawa Aktif Kulit Kayu Gmelina (Gmelina arborea) sebagai Inhibitor Spike SARS-CoV-2 Asal Indonesia Melalui Uji In Silico
Abstrak: Jati putih (Gmelina arborea) merupakan tanaman yang memiliki aktivitas antioksidan dari famili Verbenaceae. Tanaman ini biasanya dijadikan obat antidiabetes, memiliki aktivitas antioksidan, dapat meregenerasi sel serta aktivitas insektisida pada tanaman. Protein spike terdiri dari dua subunit, yaitu S1 dan S2. Subunit 1 memiliki domain pengikatan reseptor (Receptor Binding Domain/RBD) sedangkan Subunit S2 untuk proses fusi virus dengan membran. Penelitian ini bertujuan untuk menganalisis senyawa aktif dari kulit kayu Gmelina (Gmelina arborea) sebagai inhibitor dalam interaksi Spike SARS-CoV-2 asal Indonesia dengan reseptor ACE2. Senyawa aktif yang digunakan yaitu gmelinol;4- (2hydroxyethyl) phenol[2(4 hydroxyphenyl)ethanol] ;(+) balanophonin ;2,6 dimethoxy-p-benzoquinone; 3,4,5- trimethoxyphenol, serta ligan pembanding yaitu emodin dan luteolin. Parameter yang menjadi acuan yaitu energi afinitas (ΔG), konstanta inhibisi (Ki), serta jenis interaksinya (kompetitif). Balanophonin memiliki potensi yang paling tinggi di antara ligan uji lainnya karena memiliki nilai energi afinitas ikatan yang paling tinggi yaitu -5,6 kcal/mol, serta berbanding lurus dengan KI sebesar 78,10 μM., White teak (Gmelina arborea) is a plant from Verbenaceae family that has antioxidant activities. This plant is usually used as antidiabetic medicine, antioxidant activities, cell regeneration and insecticidal activity for plants. The spike protein consists of the two subunits: S1 and S2. Subunit 1 has the receptor binding domain (RBD), while Subunit 2 is used as viral fusion process with the membrane. The aim for this research was to analyze active compounds from Gmelina arborea teak bark as the inhibitor in the interaction of Spike SARS-CoV- 2 from Indonesia with ACE2 receptor. The active compounds that were being analyzed were Gmelinol;4-(2-hydroxyethyl)-phenol [2-(4-hydroxyphenyl)-ethanol] ; (+)Balanophonin ; 2,6dimethoxy-p-benzoquinone ; 3,4,5-trimethoxyphenol, with Emodin and Luteolin as the ligands comparison. The parameters for the references were Affinity energy (ΔG), inhibition constant (Ki), and the interaction type (competitive). Balanophonin has the highest potential among other ligands since it has the highest binding affinity energy of -5,6 kcal / mol, and it is directly proportional to the KI value of 78,10 μM.
Keyword: Active compounds, balanophonin, Gmelina arborea, In Silico, spike protein

Judul: Perilaku Remaja dalam Mendengarkan Radio Komunitas (Kasus Pendengar BeTe Radio di Kelurahan Tegal Gundil, Kecamatan Bogor Utara, Kota Bogor, Provinsi Jawa Barat)
Abstrak: This research aimed to analyze the relation between teenager behaviors on community radio listening activity. This research goals are (1) to identify the pattern of listening activity on community radio among teenager (2) to analyze the relation between listeners characteristics and broadcast format assessment by listening community radio (3) to analyze the relation between community radio listeners pattern with the teenager behaviors, and (4) to identify the listeners expectations towards community radio. The main method of this research is quantitative approach, and qualitative approach as supporting. Research and observationshow that the teenagers who are listening to the BeTe community radio have low level of listening activity pattern. Affective level and social network were also relatively low. Related to the listeners characteristics, the research result showed that gender does not have any relation with the pattern of radio listening activity. Beside that, age, media ownership, and main activities have significant relation towards pattern of radio listening activity. To assess broadcast format variable, pshycological proximity does not have any relation significantly with the pattern of radio listening activity. In the pattern of radio listening activity variable which is consist of listening frequency, listening duration, program choices, participation on the program have significant relation with to point of view, affective, and social network of BeTe Radio listeners.
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