Judul: Sitotoksisitas Fraksi Teraktif Biji Mahoni Berdaun Lebar (Swietenia macrophylla) terhadap Sel Kanker MCF-7
Abstrak: Tanaman mahoni (Swietenia macrophylla) memiliki aktivitas antikanker, terutama pada bagian biji. Penelitian ini bertujuan mendapatkan fraksi paling toksik terhadap larva Artemia salina pada biji mahoni, menentukan sitotoksisitasnya terhadap sel kanker payudara MCF-7, dan mengidentifikasi senyawa dugaan menggunakan liquid chromatography-mass spectrometry. Sampel dikeringudarakan dan digiling, kemudian diekstraksi dan menghasilkan ekstrak etil asetat yang mengandung golongan senyawa triterpenoid yang berperan sebagai antikanker. Ekstrak etil asetat selanjutnya difraksionasi menggunakan kromatografi cair vakum yang menghasilkan 10 fraksi. Fraksi ke-7 paling toksik terhadap A. salina dengan LC50 43.94 μg/mL. Fraksionasi kembali pada fraksi 7 menghasilkan 3 fraksi teraktif, yaitu fraksi 7a, 7b dan 7i dengan nilai LC50 berturut-turut sebesar 23.55, 34.14, dan 19.93 μg/mL. Hasil ini menunjukkan bahwa fraksi teraktif berpotensi sebagai antikanker. Fraksi 7b dengan rendemen 5.93% menunjukkan sitotoksisitas terhadap sel MCF-7 dengan persen inhibisi sebesar 76.49% pada konsentrasi 50 μg/mL. Profil kromatogram fraksi 7b diduga menunjukkan adanya golongan senyawa limonoid yang diduga berperan dalam antikanker.
Keyword: fraksionasi, sitotoksisitas, Swietenia macrophylla, toksisitas

Judul: Bioaktivitas Biji Mahoni Berdaun Lebar (Swietenia macrophylla) sebagai Antikanker
Abstrak: There are three species of mahogany in Indonesia, namely small-leaf mahogany (Swietenia mahogany), broad-leaf mahogany (Swietenia macrophylla), and Swietenia sp. This study aimed to study the toxicity of bioactive compounds in fractions of ethyl acetate extract from broad-leaf mahogany seeds, which is potencial as anticancer, by using brine shrimp lethality test. The seeds were ground into powder and air-dried. The powder was then soxhletized with nhexane. The residue was macerated in 96% ethanol. The ethanol extract was evaporated and then extracted by using liquid-liquid extraction with 1:1 ethyl acetate-water. The ethyl acetate extract yield was 5.7% (w/w). The ethyl acetate extract was further fractionated by using column chromatography with gradien elution with chloroform and ethyl acetate. Four fractions were obtained with fraction 1 (Rf = 0.95 in 1:1 chloroform-ethyl acetate eluent) was the most active fraction with LC50 of 35.46 ppm and 12% (w/w) yield. This result showed that fraction 1 was potencial as anticancer. Phytochemical test of fraction 1 gave positive results for alkaloids, saponins, steroids, triterpenoids, and tannins.
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Judul: The addition of a noun word graph dictionary module in bogordelftconstruct
Abstrak: Knowledge Graph is a new method in Natural Language Processing that is used to describe human language and displaying it into a graph form. BogorDelftConStruct is a tool to analyze Indonesian text, developed by Deni Romadoni (2009). The tool has limited feature, opening many opportunities to add some other features. The goal of this research is to develop a noun word graph dictionary module and add it in BogorDelftConStruct. The patterns of the noun word-graph are based the research of Saleh (2009). In this research, of the 20 patterns in Saleh (2009) only 13 patterns are used, since some of word graph patterns which have the same affix and also have the different meaning. As many as 144 nouns were used in scenario testing, with 1 error was generated (99,33% accuracy).
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