GSK plc (GSK, LSE)
Annual report, fiscal year 2022



## GSK

## Ahead Together

Annual Report 2022



We are a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together.

We aim to positively impact the health of 2.5 billion people by the end of 2030. Our bold ambitions for patients are reflected in commitments to growth and a step-change in performance.

We are a company where outstanding people can thrive.

## Contents

Strategic report
Ahead Together 01
2022 performance and key performance indicators 02
Chair's statement 04
CEO's statement 06
Business model 08
Our culture and people 10
Our external environment 12
Research and development 15
Commercial operations:
Performance: Vaccines 29
Performance: Specialty Medicines 33
Performance: General Medicines 38
Responsible business 41
Risk management 51
2022 principal risks summary 53
Climate-related financial disclosures 55
Nature-related financial disclosure 62
Employees by gender 63
Viability statement 64
Group financial review 65

Corporate governance
The Board and GSK Leadership Team 97
Chair's governance statement 103
Corporate governance architecture 107
Ahead Together – Board oversight 110
Key decisions and engagements 112
Board committee reports 117
Directors' report 130

Remuneration report
Chair's annual statement 133
Annual report on remuneration 136
2022 remuneration policy summary 158

Financial statements
Directors' statement of
responsibilities
Independent auditor's report
Financial statements
Notes to the financial statements
Financial statements of GSK plc
prepared under UK GAAP

Investor information
Financial record 274
Product development pipeline 278
Products, competition and intellectual property 282
Principal risks and uncertainties 285
Share capital and control 296
Dividends 298
Financial calendar 2023 299
Annual General Meeting 2023 299
Tax information for shareholders 299
Shareholder services and contacts 302
US law and regulation 304
Group companies 307
Glossary of terms 315




# Ahead Together

2022 was a landmark year for GSK. Following the demerger of our consumer healthcare business to form Haleon in July, we are now a fully focused biopharma company.

We prioritise innovation in vaccines and specialty medicines, maximising the increasing opportunities to prevent and treat disease

At the heart of this is our R&D focus on the science of the immune system, human genetics and advanced technologies, and our world-leading capabilities in vaccines and medicines development. We focus on four therapeutic areas: infectious diseases, HIV, immunology/respiratory and oncology.

## We're confident in our future

Our bold ambitions for patients are reflected in our commitments to a step-change in growth and performance over the period to 2026. This means more GSK vaccines and medicines, including innovative new products, will reach more people than ever before.
Being a responsible business means getting ahead of disease together in the right way

That’s why environmental, social and governance (ESG) impacts are embedded in our strategy and support our sustainable performance and long-term growth. They help us build trust with our stakeholders, reduce risk to our operations and deliver positive social impact.

## Culture at GSK is something we all own

It powers our purpose, drives delivery of our strategy and helps make GSK a place where people can thrive. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we’ll deliver for our patients, shareholders and GSK people.



## 2022 performance and key performance indicators

## Financial

We delivered a step-change in commercial execution with growth across the portfolio. Prioritised investment and cost discipline supported strong growth in operating profit and earnings per share (EPS).

Group turnover (£bn) \( ^{®} \) 

£29.3bn AER 19% \( ^{*} \) 
CER 13% \( ^{*} $ 

2020 24.4

2021 24.7

2022 29.3

* 2022 growth excluding COVID-19 solutions AER 16% CER 10%

Total continuing operating profit (£bn) \( ^{®} \) 

£6.4bn AER 48%
CER 31%

2020 6.0

2021 4.4

2022 6.4

Total continuing earnings per share (p)

110.8p AER 34%
CER 18%

2020 122.4p

2021 82.9p

2022 110.8p

Cash generated from operations attributable to continuing operations (£bn) \( ^{®} \) 

£79bn

2020 7.7

2021 7.2

2022 79

Turnover by product area



Vaccines
£7.9bn AER 17% CER 11%

Specialty Medicines
£11.3bn AER 37% CER 29%

General Medicines
£10.1bn AER 5% CER 1%

Adjusted operating profit (£bn) \( ^{®} \) 

£8.2bn AER 26% \( ^{*} \) 
CER 14% \( ^{*} $ 

2020 6.7

2021 6.5

2022 8.2

* 2022 growth excluding COVID-19 solutions AER 29% CER 17%

Adjusted earnings per share (p)

139.7p AER 27% \( ^{*} \) 
CER 15% \( ^{*} $ 

2020 114.4p

2021 110.3p

2022 139.7p

* 2022 growth excluding COVID-19 solutions AER 31% CER 18%

Free cash flow (£bn) \( ^{®} \)  R

£3.3bn

2020 3.7

2021 3.3

2022 3.3

We use a number of adjusted, non-IFRS, measures to report the performance of its business. Adjusted results and other non-IFRS measures may be considered in addition to, but not as a substitute for or superior to, information presented in accordance with IFRS. Adjusted results and other non-IFRS measures are defined on pages 69 and 70. AER – actual exchange rate; CER – constant exchange rate.

2020 and 2021 comparative results presented in the tables above have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business. The presentation of continuing and discontinued operations under IFRS 5 are set out on page 192.

KP Key performance indicator attributable to continuing operations R Liked to executive remuneration. See pages 136 to 139 for more details



## Performance summary and key performance indicators continued

## Research and development

We continued to strengthen the late-stage pipeline with regulatory approvals, positive data read-outs and strategic business development.

Innovation sales (£bn) RPI (R)

£12.7bn

sales of products launched in the last five years including lifecycle innovation

>20

new approvals since 2017

Innovative pipeline

69

vaccines and specialty medicines based on the science of the immune system

18

in phase III/registration

Phase III starts (R)

5

including for depemokimab in eosinophilic disease, and cobolimab for second-line non-small cell lung cancers

7

new collaborations and acquisitions including with Affinivax, Sierra Oncology and Spero Therapeutics

Pipeline value and progress  \( {}^{R} \)  are not reported externally because of their commercial sensitivity.

## Responsible business

We continue to be recognised for our environmental and sustainability leadership. Our ESG Performance Rating  \( {}^{R} \)  is on track based on 83% of all performance metrics being met or exceeded. The metrics cover our six new focus areas: access to healthcare, global health and health security, environment  \( {}^{R} \) , diversity, equity and inclusion  \( {}^{R} \) , ethical standards, and product governance (see pages 41 to 50).

1st

in the Access to Medicine Index for 8th consecutive time

2nd

in the pharmaceuticals industry for the S&P Global Corporate Sustainability Assessment, with a score of 86 (as at 17 February 2023)

13%

reduction in indirect scope 3 \( ^{1} \)  carbon emissions

## Culture

Culture progress  \( {}^{R} \)  – ambitious for patients, accountable for impact and do the right thing – is measured through our employee surveys. Our employee engagement score was 81% in 2022 compared to 78% in 2021.

+ Read more on page 10



## Chair's statement

2022 was one of the most important years in GSK’s history with strong operational and financial performance and the successful demerger of Consumer Healthcare.
As I said last year, the programme of change Emma and her team are delivering is designed to fundamentally reconstruct and strengthen GSK’s operational capability. Clear, ambitious priorities have been set to sharpen commercial execution and cost discipline; improve the pipeline and R&D productivity; tackle the Group’s structure and capital allocation capacity; and shift GSK’s culture to be more competitive and performance focused.

We are seeing clear evidence of success of this strategic transformation. But, as always, there is more to do.

We delivered the demerger and separation of GSK’s Consumer Healthcare business to form Haleon, a separate company listed in London, in July. This was the largest demerger in Europe for 20 years and the culmination of a huge amount of work over several years. We have created two attractive and competitive businesses with compelling investment propositions: a world-leading consumer healthcare business, and a newly focused GSK with a strengthened balance sheet to enable increased investment in R&D and future growth.

We are already seeing evidence of the benefits of a simpler, more focused, business model.

Operational performance for GSK in 2022 was excellent, with strong growth in sales of vaccines and specialty medicines and double-digit growth in operating profit and EPS. This is the start of a new, sustained period of growth for the Group, with sales and operating profit forecast to grow by more than 5% and 10% CAGR \( ^{1} \) , respectively over the period to 2026. The Board is very confident in delivery of these targets, underpinned by the improvement we are seeing in the Group’s commercial execution and competitiveness. Increasing R&D productivity and building a culture of performance, which take longer to embed, are critical levers of longer-term value creation for GSK.



Progress in R&D
We are making good progress in R&D. In the past five years, over 20 new medicines and vaccines have been approved and more than 18 new medicines are currently in late-stage clinical trial development.

It was good to see clear progress in our pipeline reflected in important milestones during 2022. Our respiratory syncytial virus (RSV) vaccine candidate for older adults achieved exceptional phase III results, and the US Food and Drug Administration (FDA) approval of our long-acting HIV medicine administered every two months reaffirms GSK’s leadership in next-generation HIV treatment and prevention.

We also remain ambitious to support the pipeline and future growth through business development, with acquisitions of Sierra Oncology and Affinivax completed during the year.

I was delighted by the seamless transition of Tony Wood into the Chief Scientific Officer role in August, replacing Hal Barron. Tony is an outstanding and highly respected scientist and has been a key architect in rebuilding our pipeline.



## Chair’s statement continued

## Engaging with shareholders

The Board and management continue to maintain very significant engagement with shareholders.

It is clear from these conversations that the vast majority of shareholders support the strategy the company is implementing. Nevertheless – and despite the progress that is being made – the Board recognises that there is more to do to increase investor confidence in the ability of the Group to sustain growth over the next decade.

This is important as GSK has underperformed in terms of TSR and share price performance for many years and the Board understands the need to deliver on this.

In the short term, this means consistent, year-on-year delivery of the targets for sales and operating profit, including successful launch of the company’s key new product opportunities such as the RSV vaccine in 2023.

Looking beyond 2026, successful delivery and strengthening of the late-stage pipeline is critical across vaccines and specialty medicines, including for our long-acting HIV portfolio, supported by targeted business development.

Longer term, the Board is confident that the progress the company is making to develop industry-leading AI and machine learning capabilities, and application of deep understanding of genetics, can provide us with an edge to be able to identify, develop and launch products that make a difference for patients and deliver value for our shareholders.

## Zantac litigation

The Group’s share price performance in the second half of the year was impacted by the uncertainties associated with the Zantac product liability litigation in the US. While this is disappointing, the company remains clear on its position on these matters, namely that the scientific consensus is that there is no consistent or reliable evidence that Zantac (ranitidine) increases the risk of any cancer. The decision in December by the US Federal Court in Southern Florida to dismiss all claims and cases relating to ranitidine was very welcome and GSK will continue to defend itself vigorously against claims brought at the State level.

## Targets and governance

The Board did not adopt the targets for sales and operating profit growth lightly. These commitments were a very important demonstration of our confidence in the business and our determination to be held accountable for delivery.

In line with this, we introduced a new remuneration policy in 2022 linking executive remuneration to reward for outperformance.

We engaged extensively with shareholders to develop these proposals, recognising the new reward system is a fundamental part of the architecture of GSK post-separation to ensure we build a performance culture and generate sustained delivery of shareholder value. While we were pleased the policy achieved a positive shareholder vote, we recognise a sizeable minority of shareholders voted against. We will continue to engage with shareholders to demonstrate why we believe incentivising outperformance against the targets will ultimately be rewarded through shareholder value creation.

## Operating responsibly

Operating responsibly is a foundation stone on which GSK has been built.

We are committed to ensuring ESG considerations are properly embedded into our strategy.

This supports long-term growth, reduces risk and helps us build trust with stakeholders. The Board was pleased to see continued progress in many ESG areas during 2022, including GSK again topping the independent Access to Medicines Index.

## Board evolution

Delivery of the demerger obviously resulted in changes to the Board, including departures of Vindi Banga and Vivienne Cox to Haleon and the retirement of Laurie Glimcher. I would like to thank them all for their significant contributions to GSK over recent years.

We committed to using the opportunity of the demerger to deepen the GSK Board’s biopharma experience and credentials. I was delighted to welcome Dr Vishal Sikka and Elizabeth McKee Anderson to the Board during the year. Vishal is a world-leading technologist and Elizabeth has deep commercial expertise, across both large and specialty biopharma.

Together with the continued involvement of Hal Dietz and Hal Barron, I believe the scientific credentials of GSK’s Board are among the strongest in the industry.

We also look forward to the future appointment of the highly experienced Julie Brown as our new CFO, starting 1 May 2023. I would like to thank outgoing CFO Iain Mackay for his outstanding work and support over the last four years.

I would also like to note the appointments of Anne Beal, who joined the Board in May 2021 as Chair of the Corporate Responsibility Committee, and Charles Bancroft, currently Audit & Risk Committee Chair, as our new Senior Independent Director.

Finally, I would like to thank all employees, partners, shareholders and customers for their support and commitment through the last year and I look forward to what promises to be an exciting 2023 for GSK.



Sir Jonathan Symonds
Chair



## CEO's statement

# 2022 was a landmark year for GSK. We enter 2023 with strong momentum and as a focused global biopharma company.

## Creating a focused global biopharma company

2022 was a landmark year for GSK. We successfully delivered the demerger of Haleon which is the most significant corporate change for the company in 20 years, and began a new chapter of competitive and profitable growth. We enter 2023 with strong momentum and as a focused global biopharma company with the ambition and purpose to unite science, technology and talent, to get ahead of disease together.

Strong 2022 performance increases confidence in delivering growth through 2026 and beyond
Group sales were £29.3 billion in 2022, up 13% CER, driven by strong growth in both Vaccines and Specialty Medicines. Adjusted operating profit grew 14% and adjusted EPS by 15% (both CER).
Reflecting the huge progress we have made to improve the competitiveness of our commercial execution, we now have 10 products exceeding £1 billion in annual sales, including Shingrix, Trelegy, Nucala, Benlysta and Dovato. Shingrix alone delivered a record year with £3 billion of sales. HIV sales, including Dovato, were £5.7 billion, up 12% CER.

Vaccines and Specialty Medicines now represent nearly two-thirds of our sales, compared to 46% in 2017, and we are well on track to exceed our target of 75% of revenues from Vaccines and Specialty Medicines by 2026. This evolving portfolio, together with prioritised investment in innovation and good cost discipline, is reflected in the further expansion of our operating margin.
Strong operational performance has enabled us to increase annual investment in R&D to over £5 billion and, through the demerger, we have also significantly strengthened GSK's balance sheet, creating additional flexibility to invest in growth and innovation. In 2022, we acquired the Boston-based vaccine company, Affinivax, which gave us access to the disruptive MAPS technology – for higher valency and broader coverage in a single vaccine – and a phase II next-generation 24-valent vaccine for pneumococcal disease. We also acquired Sierra Oncology, including the myelofibrosis treatment, mometolinib, which we hope to see approved in 2023, and signed an exclusive licence agreement with Spero Therapeutics for tebipenem, a novel oral antibiotic in late-stage development for complicated urinary tract infections (cUTIs). We expect to do more targeted business development in 2023.



In addition, we generated over £3.3 billion of free cash flow in 2022, supporting investments and a dividend of 61.25 pence per share for the year.

Our strong momentum underpins our confidence in delivering the ambitious sales and profit outlooks we have set for 2026. At the same time, we continue to build a stronger portfolio and pipeline based on science of the immune system, to absorb the loss of revenues from future patent expirations, and to put us in a strong position to deliver growth through the decade and beyond.



## CEO’s statement continued

Innovation supports future growth
We now have a pipeline of 69
vaccines and specialty medicines,
many with the potential to be first-
or best-in-class.

In August, Tony Wood took up his new role as GSK’s Chief Scientific Officer, succeeding Hal Barron. With his proven expertise in science, data and new technologies, Tony is well placed to capture the value and opportunities we see with our R&D approach.

We are focused across four core therapeutic areas: infectious diseases; HIV; immunology/respiratory and oncology. Overall, infectious diseases and HIV represent around two-thirds of our pipeline and our primary focus for R&D.

In infectious diseases, we have developed a potential best-in-class vaccine for RSV in older adults. We were excited to present the phase III results in late 2022, which demonstrated 94% efficacy against severe disease – an exceptional result. The world has been waiting more than 50 years for an RSV vaccine, so this is a significant scientific achievement. We have submitted this data to regulators and hope to see approval during 2023. Alongside our existing in-house capabilities, such as adjuvants, MAPS through our Affinivax acquisition and our collaboration with CureVac in mRNA, we now have the broadest suite of vaccine platform technologies of any company in the sector.

We also made important advances in the clinical development of two late-stage assets: gepotidacin, a new novel antibiotic for uncomplicated urinary tract infections (uUTIs), and bepirovirsen, which has the potential to provide a first-in-class functional cure for chronic hepatitis B, where there remains a significant unmet medical need. One in three people around the globe have been infected with the virus and more than 300 million are living with chronic hepatitis B infection today. Current standard of care for chronic hepatitis B achieves functional cure for very few patients, fewer than 5%.
With bepirovirsen, which is now undergoing final stage trials, and other assets in our pipeline, we aim to be at the forefront of a new wave of treatments for this ancient disease.

In HIV, we launched Apretude, the first and only long-acting injectable for HIV prevention which, alongside Cadenuva, the first and only complete long-acting HIV treatment regimen, means we are changing the landscape for HIV patients. We also made further progress during the year in the development of next-generation pipeline options, including presenting promising early-stage data for N6LS, our new broadly neutralizing antibody, and we look forward to providing further visibility on these pipeline options during 2023.

In immunology/respiratory, we increased R&D investment to support the phase III programme for depemokimab, a promising potential new long-acting medicine to treat severe asthma – an area in which GSK has long-standing expertise and proven commercial capability. In oncology, we reported very positive data for Jemperli as a potential treatment for patients with primary advanced or recurrent endometrial cancer. Following discussions with the FDA, we took the decision to withdraw Blenrep from the US market in November, based on the previously announced outcome of the DREAMM-3 trial.

Building trust, reducing risk and delivering positive social impact
We are committed to running a responsible business, which builds trust and reduces risk to deliver sustainable health impact at scale, shareholder returns and to support our people to thrive.

As we set out later in this report, we are making good progress in strengthening our culture, which is key to how we deliver our ambition and purpose. We are committed to making GSK a place where talented people can thrive, with a culture where we are all ambitious for patients, accountable for impact, and do the right thing. In June 2022, we introduced our new Code, which sets out our culture, as well as commitments GSK and our people make, so we can deliver our ambition and purpose in the right way.

Our ESG focus is on: access to healthcare, global health and health security, environment, diversity, equity and inclusion, ethical standards, and product governance. In 2022, we made excellent progress, maintaining our number one position in the Access to Medicines Index for the 8th consecutive time and ranking 2nd in the S&P Corporate Sustainability Assessment for the pharmaceutical industry.

As I talked about last year, investors and other stakeholders are demanding transparent reporting of performance on ESG matters. We are introducing a new ESG Performance Rating, to track delivery. I am pleased to report that our performance in 2022 is ‘on track’ with details set out on page 42.

As Jon has made clear on the Zantac product liability litigation in the US, the scientific consensus is that there is no consistent or reliable evidence that Zantac (ranitidine) increases the risk of any cancer. We will continue to defend ourselves vigorously in the State cases. From my perspective, it is important that as we do that, the company does not get distracted from our main priority – continuing to deliver on our strategy for patients, shareholders and our people.

Looking ahead with confidence
As we enter 2023, I believe GSK has compelling prospects. As ever, its our people who fuel this confidence and I want to thank them for all they have achieved during 2022 and the strong momentum they are delivering. I am very optimistic for the future and excited by what we can achieve together.



Emma Walmsley
Chief Executive Officer



## Business model

Our ambition is to positively impact the health of 2.5 billion people by the end of 2030. We aim to do this by developing transformational vaccines and medicines and making them available at responsible prices that are accessible for patients and sustainable for our business.

Central to our success are our people: experts in science, technology, manufacturing, regulation, intellectual property and commercialisation...

69,400
GSK people

£5.5bn

R&D investment in 2022
up by 9% at AER, 4% at CER

>80
countries worldwide

37
manufacturing sites

24,000
suppliers working directly
with GSK

4
global R&D centres

...who are identifying, researching, developing and testing ground-breaking discoveries, and manufacturing and commercialising...

## Vaccines

We deliver one and a half million doses of our vaccines every day; and around 40% of the world’s children receive a GSK vaccine each year.



## Specialty Medicines

Our portfolio of specialty medicines prevent and treat diseases, from HIV and respiratory diseases, to immunoinflammation diseases like lupus, to cancer. Many are first or best-in-class.



## General Medicines

Our portfolio of more than 150 products encompasses all of GSK’s primary care medicines, supplied in 112 countries worldwide.






## ...products that improve the health of millions of people around the world in our core therapeutic areas...

## Infectious diseases

We are a world leader in infectious diseases like shingles and meningitis, which, including HIV, account for two-thirds of the vaccines and medicines in our pipeline.

## HIV

Our goal is to minimise the impact of HIV on people’s lives through treatment, prevention and ultimately cure.

## Immunology/respiratory

We’re unlocking the science of the immune system to understand how it reacts to diseases like lupus, eosinophilic asthma and other inflammatory diseases.

## Oncology

Our emerging portfolio in oncology will potentially bring new cancer therapies to the patients who need them most.

## ...steered by our long-term priorities...

## Innovation

We develop new medicines and vaccines where they are needed, with better, faster and smarter R&D.

We’re combining the power of genetic and genomic insights into the causes of disease, with the speed and scale of artificial intelligence and machine learning.

## Performance

We've made commitments to growth and a significant step-change in delivery.

We are confident in our ability to sustain growth through the decade and beyond.

## Trust

We deliver our strategy responsibly: always considering the ESG impacts of everything we do from lab to patient, helping to build trust with our stakeholders, reduce risk to our operations and deliver positive social impact.

## ...and creating value for:

## Patients

2.3bn

packs of medicines and
doses of vaccines delivered

## Shareholders

61.25p

per share dividend

## Society

£1.3bn

corporate income tax paid; in addition we pay duties, levies, transactional and employment taxes

## Our people

All our people are supported to grow, be well and do work that really matters.

## Reinvestment

The returns we make enable us to reinvest in discovering and developing new vaccines and medicines so we can continue getting ahead of disease.

Company directors are required by law to promote the success of their organisation for the benefit of both shareholders and their wider stakeholders, including employees, suppliers and the community. Information on the issues, factors and stakeholders that the Board considers relevant to complying with Section 172 (a) to (f) of the Companies Act 2006 can be found on page 112.

+ Our business model is supported by our ESG strategy, described on page 42
+ Our strategy is supported by a robust framework for monitoring and managing risk, described on pages 51 and 52



## Our culture and people

GSK’s purpose – to unite science, technology and talent to get Ahead of disease Together – puts our people at the heart of our success.

## Our culture

We are committed to making GSK a place where people can thrive, with a culture where we are all ambitious for patients, accountable for impact, and do the right thing. This means we support our people to do things better and faster, focusing on what matters most. It means setting clear objectives and accountability for results and giving everyone the support and space they need to succeed. It means doing everything responsibly with care and integrity, because people and patients around the world count on us.

During 2022, we have dedicated significant leadership energy in bringing to life our Ahead Together purpose, strategy and culture across GSK. We have also placed real emphasis on individual ownership of the culture and the small changes we each need to make it a reality. This change has been supported by team conversation guides and simple tools used globally to support better and faster decision making, greater clarity of accountabilities and more ambitious, focused objectives.

In June, we introduced The Code. This sets out our culture as well as the commitments GSK and our people make so we can deliver on our ambition in the right way. GSK people sign up to The Code annually and personally commit 'I'm in'.

+ See The Code on gsk.com \( ^{1} \) 

## Making GSK a place where people thrive

Core to our Ahead Together ambition is to make GSK a place where people thrive. Although how people thrive is very individual, we also believe there are common themes that matter for all. Firstly, a belief in our purpose and a desire to live our culture and contribute to delivering our ambition. Secondly, feeling included and able to be yourself with opportunities to keep growing, with the support, feedback and space needed to succeed. And finally, feeling good, with positive mental, physical, financial and social wellbeing. This all requires GSK to be a place where people feel welcome and valued, with an environment (including our policies, workplaces and ways of working) which wholeheartedly enables and supports each person to deliver at their best.

## Supporting our people managers

Our people managers play a crucial role in helping their teams to thrive and bring culture to life. We expect people managers to Motivate, Focus, Care for and Develop their teams. Over the last two years we have delivered First Line Leader training, anchored in these four areas, to over 80% of this population. In addition, in 2022, we launched a new senior leader programme, Leading Leaders, to further build on our leadership development at more senior levels of the organisation.

In preparation for 2023, we brought all people managers together in a virtual event to bring to life our biggest priorities and support managers in setting focused, ambitious objectives with their teams, aligned to our Innovation, Performance, Trust and Culture priorities.

## Focusing on diversity, equity and inclusion

We are continuing our focus on building a more diverse organisation and an equitable and inclusive culture so that everyone feels welcome, valued and included. We are delivering our leadership representation aspirations, have implemented annual diversity, equity and inclusion (DEI) training for all, and invested in development tools to build more inclusive leaders. We support an award-winning leadership development programme, Accelerating Difference, to support women and ethnically diverse leaders. We have also continued to evolve our people policies, processes and practices to support recruitment, retention and development of a more diverse workforce. More details on our aspirational targets for DEI for our people, business and suppliers, can be found in the Responsible Business section on page 47.

## Driving Performance with Choice

Performance with Choice – our approach to hybrid working for those in office-based roles (about a quarter of our people) continues to allow us to find the right balance of on-site and remote working. This framework, balanced in driving collective and individual performance, as well as supporting individual flexibility, is supporting personal wellbeing, driving performance and making us attractive as an employer.

This year we have been clear in our expectations so that we spend enough time together in person to help us continue to build our sense of community, connectedness, enable development and better achieve our Ahead Together ambition.



## Our culture and people continued

## Developing outstanding people

We are committed to developing outstanding people and giving people opportunities to grow. All GSK people are expected to have an agreed development plan, regardless of grade or role, that is underpinned by a robust conversation to understand the space and support needed for them to succeed. We continue to invest in development initiatives and training that can be accessed by all through our Keep Growing Campus – a central platform for our training and knowledge sharing.

In 2022, we have also redesigned our talent framework – focusing our reviews for our people against performance, living our culture and future potential. This gives us a simpler assessment process, in line with our culture, to support placing our best people in our most critical roles, with strong and diverse succession plans. This allows us to spend more time on development and action planning and less on process.

## Health and wellbeing improvements

We have announced improvements to our health and wellbeing benefits, to better support people through different life stages and to make sure our offerings are fair and inclusive. These include a new global minimum standard of 18 weeks' parental leave for primary and secondary carers for all forms of family, a new global minimum standard for care of a family member for end of life or serious health emergencies, insured benefits to include same sex partners wherever possible, a new financial wellbeing service and mental health training – available to everyone.

In November, we gave a one-time discretionary payment to our people who were feeling the greatest impact of rising cost-of-living challenges. This payment was given to almost half of our global workforce in 47 of our 83 countries, using consistent criteria to determine eligible countries.
Understanding how our people experience GSK
We regularly measure how our people experience GSK, including progress in our culture focus areas and as a place to work. This includes an annual survey for all employees featuring questions on engagement, confidence, inclusivity, our culture focus areas and trust priorities. We also run a series of pulse surveys each year, with a statistically significant population, to get timely insights on our culture progress as well as hot topics of the moment. Over the last year, our progress is demonstrated by increased engagement at 81% in 2022, up from 78% in 2021, confidence in delivery of our ambitions, and positive trends in Ambitions for Patients, Accountability for Impact, Doing the Right Thing, and measures of inclusion.

To measure the effectiveness of our global manager population, their teams provide feedback via an annual One80 survey. Managers receive anonymised aggregate feedback on their effectiveness in motivating their team, focusing people on what matters most, leading with care, inclusive leadership and supporting performance and development. In 2022, 77% of our managers were rated as highly effective by their reports.

## Recognising and rewarding our people

Sharing our success and recognising and rewarding our people, not just on the progress we have made but how we have made it, continues to be an important part of our culture. In addition to our bonus scheme that rewards performance across the company, each year we award 10% of our population with extra 'Ahead Together' awards for those delivering exceptional performance in line with our culture. And 5% of people are identified as Missed Performance for those that do not deliver on their objectives or live the culture. This year, in addition to our annual bonus and long-term incentive structure, we also gave a special thank you to all our people (excluding the GSK Leadership Team (GLT)), allowing us to recognise in real time what we achieved together in preparation for separation and the unprecedented transformation of GSK: everyone received a one-off week's salary in March, separate to our 2021 bonus pay-out.

We remain energised to continually live and evolve our culture in line with the internal and external environment. It is part of everyone's objectives, starting at the top, with all leadership team members having ambitious goals to embed and grow culture, and shows up in how we act every day.



## Our external environment

Here, we set out five major themes that have influenced our environment – and how we work with governments, regulators and industry partners to keep providing medicines and vaccines to patients worldwide.

## Life sciences continue to be shaped by new technology

Rapid advances in science and technology are changing life sciences R&D. This is particularly evident in the expansion of artificial intelligence and machine learning (AI/ML), which has the potential to transform outcomes for patients by making R&D more precise and productive. Research has identified nearly 270 companies working in the AI-driven drug discovery industry. \( ^{1} \)  We’re investing in building our own AI/ML capabilities and forging partnerships to further strengthen our position. Other biopharma companies are also collaborating with AI organisations, with 46 partnerships struck in 2022, compared to 28 in 2016. \( ^{2} \) 

The pivotal role of innovation in managing the COVID-19 pandemic underscored the potential of new technologies and approaches to improve patient outcomes. Growth areas include next-generation vaccines, where there has been a substantial increase in assets in development, driven by the advancement of mRNA and DNA vaccine technology.

Greater use of new technologies and digital tools, as well as growth of decentralised trials, is accelerating a drive towards modernisation of clinical trial and regulatory processes. Governments and regulators are continuing to build on lessons learned from COVID-19 and expand international collaboration on complex trials and further develop policies and infrastructure for responsible access to public datasets. As AI/ML advances, different regulatory approaches on the use of AI in medicines are emerging.

Collaboration is also needed to create common models and standards for AI regulation that support innovation and benefit patients.

+ Read about our focus on data and platform technologies on pages 18 and 19

270

companies working in the
AI-driven drug discovery industry

## Geopolitical tensions prompt countries to shift their priorities and focus

Scientific and technological advances offer significant promise for patients. But geopolitical tensions are putting pressure on the systems needed to deliver this innovation. Rising nationalism and friction between countries, due to the conflict in Ukraine and tensions between the US and China, bring potential risk and disruption. In the face of these tensions, governments are taking more interventionist actions to protect their domestic economic competitiveness, strengthen national security, create domestic jobs and improve public health.

There were notable examples of solidarity during the year. Constructive World Trade Organization discussions about reducing tariffs demonstrated that governments recognise the importance of minimising trade friction. But domestic interests remain the priority with governments encouraging companies to localise and shorten value chains \( ^{3} \) , prioritising strategic resilience over efficiency. Policies to restrict trade and secure access to essential items including medical goods have persisted. For example, in 2022, governments introduced over 150 harmful policy interventions affecting trade in pharmaceutical goods. \( ^{4} \) 

In an environment defined by tensions, trade disruption and economic uncertainty, health and life sciences continue to be viewed as sectors of strategic importance for governments across advanced markets, including the US, Europe and the UK. In March 2022, the US enacted a new federal agency – Advanced Research Projects Agency for Health – to improve the government’s ability to speed biomedical and health research. Life sciences was earmarked as a key strength in the UK government’s new Growth Plan. \( ^{5} \)  Given their potential to bolster economic productivity and protect lives, healthcare and life sciences are likely to be subject to more muscular industrial policy interventions such as additional support for R&D, as well as state scrutiny over supply chain resilience.

## >150

In 2022, governments introduced over 150 harmful policy interventions affecting trade in pharmaceutical goods



## Economic slowdown as energy crisis and inflation bite

Lockdowns at the height of the pandemic weighed on economies worldwide and the outlook continued to weaken in 2022. Global growth was forecast to slow to 3.2% in 2022 \( ^{6} \)  amid surging inflation, heightened geopolitical uncertainty and tightening financial conditions. Energy prices soared across Europe due to increased demand and restricted supply, contributing to rising inflation. This has had immediate and challenging consequences for individuals and businesses.

With energy prices climbing, governments have staged significant and costly interventions to protect households, seek alternative energy sources, and invest in renewable energy infrastructure. Government interventions on this scale risk growing fiscal deficits and put pressure on other areas of public spending, including healthcare. During the pandemic, healthcare spending increased as governments rolled out vaccination programmes. But spending is estimated to have fallen in real terms during 2022 as it failed to keep pace with inflation. \( ^{7} \)  Medicines spending is expected to return to pre-pandemic growth rates by 2024, albeit with pricing and value under increasing scrutiny over the next few years due to economic pressures and geopolitical disruption. \( ^{8} \) 

As governments meet economic headwinds, cost containment measures are on the rise, with healthcare budgets facing significant pressures in the UK, EU and other advanced markets. In August 2022, the US President signed into law the Inflation Reduction Act. This includes provisions to drive down US national debt through higher taxes, lowering energy costs, and lowering drug prices. Parts of the Act that focus on patients are welcome as they bring benefits to people who would otherwise face challenges accessing important vaccines. But there are concerns over negotiation provisions, allowing the federal health secretary to negotiate prices of certain expensive drugs each year for Medicare. This could potentially limit investment in innovation.

As well as cost containment, we are also seeing more examples of innovative contracting to support prudent stewardship of healthcare spending. Companies and payers are continuing to explore innovative pricing models, which facilitate patient access and support payer confidence in the value of a medicine or vaccine at the time of launch.

+ Read more about pricing and access on page 43

3.2%

Global growth was forecast to slow to 3.2% in 2022

## Green transition disrupted but long-term momentum remains

The energy crisis has not only weakened economies, but also disrupted the green transition. Amid concerns over reliability, supply and affordability, policymakers face conflicting priorities. While energy transition is necessary to mitigate climate change, immediate energy needs are driving renewed investment in traditional fossil fuel energy sources. European countries announced plans to revert to higher coal usage to produce electricity, while the US has taken steps such as reopening oil and gas leasing on public lands. Investor sentiment, particularly in the US, has seen similar shifts as the ESG agenda becomes increasingly polarised and politicised. During the year, Florida and Texas implemented measures banning their pension funds from investing through any asset managers that have policies on excluding fossil fuels or taking ESG factors into account.

Against this fractured backdrop, corporate net zero efforts remain in the spotlight with stakeholder expectations on credibility and transparency on net zero continuing to rise. But voluntary commitments and coalitions are being tested with, for example, the UN-backed Race to Zero dropping its explicit bar on support for new coal projects.
Despite the disruption seen during 2022, getting ahead of climate change remains a long-term investor and societal expectation, and a government priority. This was reinforced by the $369 billion clean energy investment in the US Inflation Reduction Act. Any setback to the energy transition is likely to be time-limited, so companies must continue to demonstrate leadership on the issue and remain committed to cutting their climate impact.

+ Read more about climate and nature on pages 45 and 46

$369bn

allocated to climate and clean energy programmes in the US Inflation Reduction Act



## Our external environment continued

## Access in focus as COVID-19 shines light on health inequity

COVID-19 demonstrated the value of the life sciences sector and the potential for delivering innovative interventions at speed. But the pandemic also raised questions about the pace at which medicines and vaccines could be rolled out, shining a light on inequalities in access and healthcare outcomes both within and between countries. Around 26% of people in low-income countries are partially or fully vaccinated against COVID-19, compared with 80% in high-income countries. \( ^{9} \) 

Scrutiny of the COVID-19 vaccine rollout has reignited the debate around the intersection between intellectual property (IP) rights and access to medicines and vaccines. This was evidenced by the TRIPS waiver, agreed in June 2022, which temporarily removes developing country obligations on patent protections for COVID-19 vaccines. Such a step doesn’t address inequitable access and instead undermines industry’s ability to partner, invest at risk, and respond quickly to future pandemics. Industry has sought to encourage a more holistic approach to realising equitable and timely access during future pandemics. This recognises the multiple factors that enable access, such as sustainable funding and free trade. The international pharmaceutical industry, along with biotech and vaccine manufacturers based in developing countries, united behind a vision for access in future pandemics, known as the Berlin Declaration. This outlined industry’s willingness to reserve an allocation of real-time production for distribution to priority populations during future pandemics. The success of such an approach will rely on having a strong innovation ecosystem; removal of regulatory and trade barriers to export; procurement mechanisms for low- and middle-income countries; and robust health systems.

More resilient health systems are needed not only to counter the increasing threat of infectious disease emergencies, but also to manage the growing burden of non-communicable diseases. Delays to cancer diagnosis and treatment during the pandemic could have an adverse effect on survival for years to come. As health systems continue to manage the long-term repercussions of the pandemic, there is an opportunity to move towards new models of care that enable earlier action to prevent, diagnose and treat disease. Investing in prevention to get ahead of disease has a clear return. It improves health outcomes, is cost-effective, and contributes to healthier lives, societies and economies.

+ See pages 43 to 45 for more on pricing and access, and global health and health security

26%

of people in low-income countries are partially or fully vaccinated against COVID-19

## Our position

In a challenging economic and political landscape, it’s more important than ever that we invest in a pipeline of vaccines and specialty medicines that will meet changing and unmet healthcare needs. At the same time, we have to work with governments, regulators and industry partners to make sure these medicines and vaccines can reach patients, bringing value to both the people who need them and payers.

Scientific innovation and improving health remain a critical pathway to sustainable economic growth. We therefore continue to work with our peers and governments to make sure that the policy and regulatory environment stimulates and sustains innovation. This includes, for example, advocating for appropriate IP protections; a balanced regulatory framework that supports the discovery and delivery of vaccines and medicines developed through emerging technologies; and reinforcing the importance of global, diversified supply chains.

As the pricing environment becomes tougher, we are well placed to offer a differentiated, high-value pipeline across prevention and treatment of disease. This is built on using new technology and techniques to make our R&D faster and smarter. Demand for data and real-world evidence to support continued reimbursement of new products is likely to increase. We continue to work with payers to design innovative solutions that manage their risk and uncertainty, while also recognising the full health, social and economic value of innovative medicines and vaccines. We also continue to collaborate with global health partners to increase our reach to patients in lower income countries.

To support delivery of innovative medicines and vaccines, we continue to advocate for investment in resilient healthcare systems around the world. More robust infrastructure is needed to support, for example, routine life-course immunisation. Getting ahead of future pandemics, and managing them more effectively when they do happen, starts with investing in health systems and improving public health now.



# Research and
development

Science and technology have never before opened up so many possibilities for new vaccines and medicines for patients. In 2022, we've continued to harness the science of the immune system alongside genetics, genomics and advanced technology to continue to strengthen our pipeline.






## Research and development

## Highlights

69

vaccines and medicines
in the pipeline

>20

new approvals
since 2017

2/3rds

of our pipeline comes from infectious diseases and HIV

– Potential best-in-class RSV older adults candidate vaccine filed in US, EU, Japan

– Shingrix interim 10-year data presented at ID Week 2022

– Continued progress in development of long-acting HIV treatments; positive phase II data on N6LS broadly-neutralising antibody presented at HIV Glasgow

– Pivotal phase III trials for gepotidacin antibiotic for uUTIs stopped early for efficacy

– Positive phase IIb data for bepirovirsen, our investigational treatment for chronic hepatitis B, and started phase III study in early 2023

## Our R&D approach

R&D is central to our purpose to get ahead of disease together. By combining the science of the immune system, genetics, genomics, advanced technologies and outstanding talent, we discover and develop vaccines and medicines to make a transformational impact on people’s lives.

In 2022, R&D expenditure was £5,488 million, up 9% at AER, 4% at CER, from 2021 and we have strengthened our pipeline and platform capabilities through strategic business development. This means we have 22 vaccines and 47 medicines in development (see page 28). Many have the potential to be first-in-class.

Our late-stage R&D aligns to four therapeutic areas:

– infectious diseases, see page 20

– HIV, see page 23

– immunology/respiratory, see page 24

– oncology, see page 25

– Expansion of depemokimab phase III programme with trials for long-acting IL-5 inhibitor in three additional eosinophil-driven diseases

– Business development including: acquisition of Affinivax giving access to disruptive MAPS technology and phase II next-generation vaccine for pneumococcal disease; acquisition of Sierra Oncology adding mometolinib for myelofibrosis patients with anaemia (regulatory submission EU, US); and exclusive licence with Spero Therapeutics giving access to tebipenem HBr, a late-stage antibiotic for cUTIs

Our research team takes an approach that follows the science to identify opportunities with the greatest probability of success to lead to differentiated vaccines and medicines, including opportunities outside these four areas. Our scientists prioritise genetically identified targets that are at least twice as likely to succeed in the clinic. They also prioritise infectious disease targets and immune-modulators that have greater lifecycle opportunities.

## Prioritising execution and technology

Our priorities are:

– flawless execution of our late-stage pipeline and acceleration of our organically derived pipeline

– doubling down on technology to deliver further innovation faster

– finding new ways to help patients through lifecycle innovation

– targeted business development to push towards new discoveries



## Research and development continued

## Flawless execution and acceleration of our pipeline

Our pipeline, across all phases, has 69 potential vaccines and medicines, more than 70% of them modulating the immune system and more than 70% with human genetic validation. In 2022, we started 16 phase I programmes, moved nine candidates into phase II and started five phase III programmes.

We also achieved industry-leading milestones, including the approval and launch of the first long-acting HIV medicines and the FDA priority review of the exceptional RSV older adult vaccine candidate with a potential best-in-class profile. We also presented new data at IDWeek 2022 showing that Shingrix can provide at least 10 years of protection against shingles in the over 50s, and completed our acquisition of Affininax.

We have made significant progress in improving key measures of productivity. We reduced overall cycle times by 20% from the start of new drug discovery projects through to the end of phase I (for 2019-2021 compared to 2016-2018), and we now have a phase I portfolio that includes many potential first-in-class medicines.

## Doubling down on technology to deliver further innovation faster

We believe the combination of science and technology holds the key to fundamentally transforming medical discovery, improving success rates and shaping how we treat and prevent even the most challenging diseases. This is why technology plays a growing role in progressing our R&D towards vaccines and medicines not previously thought possible. It covers:

– data technology, which helps us to understand the patient and human biology, choose targets and design clinical trials. We have access to large, rich datasets thanks to our data-focused collaborations, including our recent collaboration with Tempus (see page 19) as well as established partnerships, for example with 23andMe, the UK Biobank, and the Laboratory of Genomic Research with the University of California (see page 18)

– platform technology, for the efficient design and development of new vaccines and medicines. We have access to a broad set of platform technologies, including an unrivalled suite within vaccines like mRNA, MAPS and adjuvant science, and a growing investment in oligonucleotides (see page 19)

## Finding new ways to help patients through lifecycle innovation

We look to innovate throughout the lifecycle of our vaccines and medicines by exploring new ways for them to treat patients. Examples include:

– approval in the US for Boostrix, for immunisation during pregnancy to prevent whooping cough in newborn babies

– FDA approval for a new, more convenient presentation of our Rotarix vaccine to prevent gastroenteritis caused by rotavirus

– approval for Priorix, our vaccine against measles, mumps and rubella, in the US for children over 12 months

– approval of a two-dose regimen for Cervarix, our human papillomavirus vaccine for girls aged 9 to 14, in China

– approval in China for Benlysta to treat adults with active lupus nephritis (LN) and FDA approval for Benlysta for paediatric patients with active LN

– continue to develop a new monoclonal antibody, depemokimab, under development for its high affinity and long-acting suppression of IL-5 function

## Pushing towards new discoveries through strategic business development

We work with commercial organisations and academic institutions to find new research and discovery opportunities, access new technology platforms or to progress the development of our pipeline. We remain agile and ambitious, looking for opportunities that address high unmet medical needs and complement our R&D strategy.

We look to grow our pipeline through acquisitions. In 2022, these included Affinivax adding a novel class of next-generation pneumococcal vaccine candidates and innovative MAPS technology (see page 20), and Sierra Oncology adding mometolinitb for the treatment of myelofibrosis (see page 25).

We also announced five new collaborations, giving us access to exciting new vaccines, medicines and technologies, and deepening our understanding of how to prevent and treat disease. We partnered with precision medicine company Tempus, with oncology being a first area of focus. We added to our pipeline through new partnerships with Mersana Therapeutics for an option to co-develop and commercialise their XMT-2056

immunosyn them antibody-drug conjugate in oncology, with WuXi to progress bi-specific T-cell engaging antibodies for oncology and with Zheming to progress a phase I TLR8 agonist for hepatitis B virus (HBV). We announced a new partnership with Wave Life Sciences to drive discovery and development of oligonucleotide therapeutics, including a programme for alpha-1-antitrypsin deficiency with a novel RNA-editing mechanism of action, and we also announced an exclusive licence agreement with Spero Therapeutics for tebipenem HBr, a late-stage antibiotic that may treat cUTIs.



## Genetics, genomics and advanced technologies

To get ahead of disease, we use innovative tools to maximise our chances of success and accelerate the pace of discovery. Genomics and the predictive power of AI/ML are changing how we find the right medicines for the right patients.

Advanced technologies and real-world data are bringing patients into the discovery and development process earlier. This, in turn, improves how researchers can integrate data into decision making. For diseases like cancer or neurological conditions, we’re investigating how tools like genetic validation, wearables, genomics and AI/ML can provide important insights that make us better at choosing drug targets and the specific groups of patients in which to study them.

Data produced using these tools helps us:

– select novel targets that are genetically validated and so more likely to become approved medicines and vaccines

– design clinical trials to include the patients most likely to benefit from our potential medicines and vaccines

– recruit these patients faster, and accelerate the pace of our clinical trials

## Improving drug discovery with the power of genomics and partnerships

Today, more than 70% of the projects in our pipeline are supported by human genetic evidence, informed by the large genetic datasets from our ongoing collaborations with the UK Biobank, 23andMe and FinnGen. In 2022, we were a founding member in the creation of Our Future Health, an ambitious UK effort aiming to recruit up to five million people to capture a wide range of medical and genetic information. We're also working with Genes & Health and Discover Me South Africa to further expand this work and ensure a diverse and robust genetic representation of diseases.

In our collaboration with the consumer genetics and research company 23andMe we have approximately 50 active joint drug discovery programmes for genetically validated targets. In 2022, we extended our collaboration for a fifth year to identify and validate additional new drug targets until July 2023. This year we also took on sole development responsibility for phase I of the collaboration programme consisting of an investigational antibody targeting CD96 as a novel immuno-oncology agent. This is an investigational antibody that is currently being evaluated for cancer alongside other GSK medicines. Several collaborations in functional genomics are providing further insight to improve our target selection. We work with a range of institutions innovating in this fast-moving field, from CRISPR pioneers to start-ups. In the US, this includes dedicated genomics research centres, such as the Altius Institute in Seattle and the Broad Institute affiliated with MIT and Harvard University in Boston. We continue to partner with Adrestia, a British biotech, and with Open Targets, a UK consortium where we're a founding member.

These advances complement the progress we're making at the genomics lab we founded in 2019 with CRISPR pioneers at the University of California in San Francisco. The Laboratory for Genomic Research is now advancing a portfolio of 16 active technology and biology projects. By automating and advancing CRISPR, our scientists work side by side with academic researchers to uncover new knowledge about disease mechanisms for immunology, oncology and neurology. Scientists are creating new technologies that stem from CRISPR, and they are identifying additional applications of these technologies to find better starting points for new medicines.

CRISPR and other tools contribute to the data we have to understand the underlying causes of disease. Other information sources range from tissue and blood samples to human behaviour from wearable technology. Our proprietary AI/ML capabilities help our researchers interpret this volume of data and also make connections and predictions that help identify which targets are most likely to succeed. As assets move through our pipeline, both AI/ML and functional genomics continue to play a role, including in optimising clinical trial design, for example as happening now with bepivorisen.

## Building in-house AI/ML teams and expanding our collaborations

AI/ML enables us to generate deeper insights from our own research data and our collaborations. Our work in applied AI/ML primarily focuses on two areas in R&D: at the early discovery stage to find genetically validated targets, and at the clinical stage to match patients with the right medicines.

We’ve built one of the largest in-house functions dedicated to AI/ML, and we work with partners to lead the way in these fields. Our AI/ML team includes more than 160 experts based at key GSK R&D sites, including London, San Francisco, Tel Aviv, Philadelphia and Boston. Combining our team with the resources and expertise of our partners helps us collect more data, find patterns in genetic data faster than we could before and, ultimately, helps us increase our success rates in making life-changing medicines. We continue to expand our partnerships with world leader data aggregation companies such as Tempus to further complement our internally generated data.



## Research and development continued

Our models are becoming more and more advanced with every iteration. We've created a new imaging tool using AI/ML that we are using to inform target selection and potential business development opportunities in a challenging and complex disease area, non-alcoholic steatohepatitis (NASH).

Also, through a partnership with King's College London, we're using tumour models alongside digital pathology and AI to develop personalised immuno-oncology treatments for several solid cancers, including lung, gastrointestinal and women's cancers.

The Oxford-GSK Institute of Molecular and Computational Medicine (IMCM), which we established in partnership with Oxford University in December 2021, combines human genetics with functional genomics and ML to focus on neurological diseases like ALS, Alzheimer's and Parkinson's.

Our collaborations in data technology complement our existing capabilities and resources and include ongoing work with Cerebras, the pioneer in high performance AI computer systems, and NVIDIA, a global leader in AI hard and software. In 2022, we started two other data collaborations:

– PathAI, a global leader in AI-powered pathology, aimed at accelerating R&D in oncology and NASH. We’ll combine our predictive and data-driven approach to drug discovery and trials with PathAI’s models to build algorithms that uncover new insights. We’ll integrate these into trials to help us predict which patients will be impacted most

– Tempus, which enables access to their library of de-identified patient data. Tempus’ dataset draws from its work with over 40% of oncologists in the US at academic medical centres and community hospitals. We will work with Tempus to improve clinical trial design, speed up enrolment and identify drug targets, with an initial focus on oncology

## Platform technology across vaccines and medicines

Our work to use technology to drive drug discovery also includes expanding our platform capabilities. These technologies allow us to broaden the range of options for future medicines and vaccines, going beyond existing modalities like small molecules, antibodies and adjuvants to help immune responses to vaccines, but importantly also ensure we remain highly competitive by being faster and more confident in identifying new medicines from our genetically validated targets.
We develop these technologies ourselves and through external collaborations. Key areas for new medicine and vaccine technologies that we're actively investing in include:

– MAPS (multiple antigen presenting system), a novel and highly efficient vaccine technology platform that potentially enables broader coverage, generating higher antibody responses. MAPS has mainly been directed at preventing pneumococcal disease and has also shown promise in addressing other infectious disease pathogens, including those that cause hospital-acquired infections

– mRNA, which was validated by the launch of the COVID-19 vaccines in 2020 and could potentially be applied across a number of diseases. We're progressing the development of the mRNA technology in-house, in parallel with our CureVac collaboration. We're currently evaluating a second generation mRNA backbone, which we developed with CureVac, in a phase I trial featuring modified mRNA vaccine candidates targeting COVID-19 and flu. Based on the promising preliminary analysis of these studies, evaluating safety, reactogenicity and immunogenicity, we are preparing to move these candidates into late-stage clinical testing

– RNAi and oligonucleotides including: ARO-HSD, a phase II programme for NASH, in-licensed from Arrowhead in 2021, consisting of an RNA interference (RNAi) molecule against a genetically validated target; and bepirovirsen, an anti-sense oligonucleotide designed to recognise HBV DNA, in phase III, which we in-licensed from Ionis in 2019. We also announced a collaboration with Wave Life Sciences, which allows us to advance up to eight preclinical programmes using Wave's PRISM oligonucleotide platform and includes the in-licensing of a novel RNA-editing oligonucleotide to treat liver and lung disease caused by alpha-1-antitrypsin deficiency

– monoclonal antibodies (mAbs) such as Xevudy for COVID-19, co-developed with Vir Biotechnology, as well as other research programmes

– new ways to understand the biology and pharmacology of genetically validated targets and how best to intervene in their disease processes. Our Chemical Biology group has developed several such methods, including chemogenomic libraries, encoded libraries, and reactive fragments, in part in collaboration with the Francis Crick Institute. These novel technologies help find critical starting points for drug discovery projects

– natural products derived from the biosphere, such as the collaboration we started with LifeMine Therapeutics in 2022, which gives us access to its platform for proprietary evolutionary-derived genomic drug discovery

– bi-specific antibodies for multiple auto-immune diseases that are advancing through preclinical phases

– digitisation to optimise each phase of vaccine development and production. Working with Siemens and Atos, two of the world’s leading digital transformation and technology companies, we’ve developed a ‘digital twin’, a complete and real-time simulation of the vaccine manufacturing process.



## Infectious diseases

Two-thirds of the vaccines and medicines in our pipeline address the global public health burden of infectious diseases, such as those caused by HIV, RSV, meningococcal, hepatitis B, rotavirus and antibiotic resistant bacteria. These diseases cause significant morbidity and mortality and put strain on global healthcare systems.

In 2022, we generated pivotal data for our RSV candidate vaccine for older adults and positive interim analysis readout for gepotidacin, our antibiotic to treat uUTIs and gonorrhoea. Both have the potential to be first and best-in-class.

We also sought opportunities to boost our pipeline through business development. In 2022, we completed our acquisition of the clinical-stage biopharmaceutical company Affinivax. It has pioneered a novel class of next-generation pneumococcal vaccine candidates. These include a 24-valent vaccine candidate for adults, which has completed phase II, and a paediatric version currently in phase II. A 30-plus valent pneumococcal vaccine programme is in pre-clinical development. These vaccines incorporate the MAPS technology (see page 19).

Our new partnership with Spero Therapeutics, Inc. gave us an exclusive licence agreement for tebipenem HBr, a late-stage antibiotic being developed by Spero. This is the first oral carbapenem antibiotic, and it has the potential to treat cUTIs. With a clear FDA regulatory path to potential approval, tebipenem HBr will address an unmet medical need for a novel oral antibiotic as an alternative to intravenous hospital therapy for drug-resistant cUTIs.

## RSV

RSV is a major cause of acute respiratory illness in older adults and is currently one of the major infectious diseases without a vaccine. RSV can worsen underlying conditions and cause pneumonia. It leads to approximately 420,000 hospitalisations and over 29,000 deaths a year in adults in industrialised countries. Around 94% of people hospitalised with RSV have underlying comorbidities.

In 2022, we became the first company to announce positive phase III efficacy data for a RSV older adult vaccine candidate. Interim results from our ARESVI-006 phase III pivotal trial showed vaccine efficacy of over 94% \( ^{1} \)  observed against RSV lower respiratory tract disease (RSV-LRTD) in adults with at least one comorbidity of interest and in those with severe disease. Overall vaccine efficacy against RSV-LRTD was 82.6% \( ^{1} \) , meeting the trial's primary endpoint. Consistent high vaccine efficacy was observed across a range of pre-specified secondary endpoints, including against severe disease, in adults aged 70-79 and across RSV A and B strains.
The vaccine was generally well tolerated, with a favourable safety profile. These data were presented as part of the Infectious Disease Society of America's IDWeek 2022 annual meeting in Washington, DC, in October. We also shared positive data on the co-administration of our RSV older adult vaccine candidate with a flu vaccine, a key finding for practical immunisation.

Based on these data, the vaccine candidate was granted Priority Review by the FDA. It was also accepted for accelerated assessment by the European Medicines Agency (EMA) and for review by the Japanese Ministry of Health, Labour and Welfare (MHLW).

We’re committed to finding solutions for people at high risk of the serious consequences of RSV infection. In 2022, we started a clinical trial exploring the effect of the RSV older adult vaccine candidate in people aged 50–59, including those at increased risk of RSV-LRTD, compared to people 60 and over. We also began two further flu co-administration trials. The ARESVI-006 trial will also continue to evaluate an annual revaccination schedule and longer-term protection over multiple seasons.

## Shingles

Approximately one in three adults develop shingles, a painful and potentially serious illness. Shingrix is the first approved shingles vaccine to combine a non-live antigen with one of our adjuvants. It may help overcome the natural age-related decline in immunity that contributes to the challenge of protecting people aged 50 and over from this disease.

Shingrix is now available in 26 countries, and we've continued to broaden access to it in 2022. In Japan, where Shingrix is already approved for people over 50, we've also submitted an application to extend the indications to include over 18-year-olds at risk, such as those with immune suppression and immune deficiency. The US Cancer Network has recommended Shingrix for cancer survivors over 19, and the vaccine has a preferential recommendation from the Brazilian Immunization Society.

We presented new data at IDWeek 2022 showing that Shingrix can provide at least 10 years of protection against shingles in the over 50s. In the primary endpoint analysis, the interim data showed overall efficacy of more than 80% \( ^{2} \)  in the follow-up period of approximately six to ten years after initial vaccination. No new safety concerns were identified during the follow-up period. These data significantly add to the real-world evidence demonstrating the long-term benefit of Shingrix.



## Research and development continued

## Meningitis

Around 1.2 million people develop invasive meningococcal disease (IMD) each year. It can be fatal, and 10–20% of survivors will have long-term disabilities such as brain damage, deafness, nervous system problems or loss of limbs. Bacterial meningitis is also of particular concern. One in 10 people who are diagnosed with bacterial meningitis end up dying, and 1 in 5 are left with severe complications.

Bexsero, our meningitis B vaccine, and Menveo, our meningitis ACWY vaccine, are registered in more than 60 countries, and together protect against most forms of IMD. Since launch, more than 150 million doses of these vaccines have been distributed. In 2022, we received FDA approval in the US and ANVISA approval in Brazil for a fully liquid, ready-to-use single vial presentation of Menveo. This gives healthcare providers a more convenient option by removing the need to reconstitute the vaccine.

Our investigational first generation MenABCWY candidate pentavalent (5-in-1) vaccine combines the technologies used in our Bexsero and Menveo vaccines. The goal of introducing a 5-in-1 meningitis vaccine is to protect people against the five serotypes that cause most disease with just one vaccine, not two. A 5-in-1 meningitis vaccine has the potential to help improve vaccination rates by providing a more convenient way to prevent IMD.

MenABCWY is currently in phase III development, in a trial spanning five countries with 3,650 participants aged 10-25. We expect results in early 2023. New multivalent vaccines like this have the potential to support the global strategy to defeat meningitis by 2030, set out in the World Health Organization’s Global Road Map.

A second-generation 5-in-1 meningitis vaccine is currently in phase II and is aimed at improving protection against B strains and allowing for broader age indications globally.

## COVID-19

By the end of 2022, more than 650 million cases of COVID-19 had been reported around the world, and there had been over 6.5 million deaths. The disease continues to challenge healthcare systems. We and our innovation partners have been part of the response, developing treatments and vaccines.

## Treating COVID-19 with Xevudy

Xevudy (sotrovimab) is our SARS-CoV-2 monoclonal antibody treatment, developed with Vir Biotechnology. It works by preventing the virus from entering and infecting healthy cells in the body. It has been an important part of early treatment to prevent high-risk patients from developing severe disease. With Vir, we developed sotrovimab from discovery to approval in less than 1.5 years. We have delivered over two million doses of Xevudy to over 30 countries including government purchases to meet current and future need.
Providing solutions with new COVID-19 vaccines
Our pandemic adjuvant technology is part of several protein-based COVID-19 vaccines we've developed, such as with Sanofi and SK bioscience, which are now licensed in some markets. These vaccines are important new options to help protect against COVID-19.

## Chronic hepatitis B

Chronic hepatitis B (CHB) is a major global health issue with approximately 300 million people infected and approximately 900,000 people dying annually due to liver complications, including cirrhosis and liver cancer. The mainstay of therapy includes nucleoside/nucleotide analogues (NA) which are often taken for life because they suppress but rarely clear the virus.

Bepirovirsen is the only drug in development as a monotherapy for CHB that works to reduce virus replication, suppress surface antigen and stimulate the immune system. In November 2022, phase II full-study data published in The New England Journal of Medicine demonstrated that treatment with bepirovirsen resulted in sustained clearance of hepatitis B surface antigen (HBsAg) and HBV DNA in a sub-group of patients followed for six months after discontinuation of their bepirovirsen. Levels of HBsAg and HBV DNA together are key efficacy measures. When HBsAg and HBV DNA remain undetectable for more than six months without medications, patients are considered to have a functional cure, an outcome associated with significant decreased risk developing cirrhosis, hepatocellular carcinoma and death. Currently, standard of care treatment with NA rarely achieves functional cure, which is why new therapies are needed for patients diagnosed with chronic HBV. Our phase III study which started in early 2023 will build our understanding of how bepirovirsen works. Our aim for bepirovirsen is for it to become a potential monotherapy or the backbone of future therapy for hepatitis B patients. We are exploring potential sequential treatment trials and expect to share data later in 2023.

## Other infectious diseases

## Dipheria, tetanus and pertussis

Since 2010, there have been up to 48,000 cases of pertussis (whooping cough) in the US each year, with infants more likely to experience complications from the disease. Boostrix, our tetanus, diphtheria and pertussis vaccine (Tdap), received approval from the FDA in October 2022 for immunisation during the third trimester of pregnancy for the prevention of whooping cough in newborn infants. This makes it the first vaccine in the US approved specifically for use during pregnancy. The vaccine is approved in 80 countries, including in the EU, Canada, Australia and New Zealand.



## Research and development continued

## Rotavirus

In November 2022, the FDA approved the new fully liquid presentation of our Rotarix vaccine to prevent gastroenteritis caused by rotavirus. This new presentation makes it more convenient for healthcare providers to prepare Rotarix by removing the need to reconstitute the dose at the point of use. We expect it to be commercially available in early 2023.

## Varicella

In February 2022, we started a phase II study in the US with children aged 12-15 months to compare the safety and immunogenicity of our varicella (chickenpox) new strain candidate vaccine with the vaccine currently available. The aim is to develop a vaccine that fits the Advisory Committee for Immunization Practices' (ACIP) recommended US immunisation schedule and offers healthcare professionals and parents an alternative to the current vaccine. This varicella new strain vaccine could also be used as a component of the measles-mumps-rubella-varicella vaccine in the US.

## Herpes simplex virus

We have started a phase I study to investigate the potential of GSK 3943104A, an immunotherapeutic against herpes simplex virus (HSV). The aim is to offer a better solution for people with the virus than current standard of care. The study is gathering safety and immunogenicity data on GSK 3943104A in healthy people. Phase II development will focus on safety and immunogenicity, as well as proof-of-concept efficacy.

## Human papillomavirus

Human papillomavirus (HPV) is a common sexually transmitted infection – around 14 million people a year become infected in the US alone. It often has no symptoms but can cause genital warts or cancer. We’ve begun a phase I/II study of our next-generation adjuvanted vaccine, developed in collaboration with Innovax, to protect against nine types of HPV. The study is evaluating the reactogenicity, safety and immunogenicity of an adjuvanted vaccine candidate for girls and women aged 16-26. The aim is to identify the most effective vaccine formulation to take into phase III trials.

We also received approval in China for Cervarix, our human papillomavirus vaccine for girls aged nine to 14, in a two-dose regimen.

## Pneumococcal disease

Pneumococcal disease is the term for any illness caused by the bacterium Streptococcus pneumoniae, a leading cause of acute bacterial disease worldwide. Our acquisition of Affinivax adds a novel class of next-generation pneumococcal vaccine candidates that incorporate MAPS technology (see pages 19 and 20).

## Antibiotics and antimicrobial resistance

According to the World Health Organization (WHO), antimicrobial resistance (AMR) is one of the top 10 global health threats. By undermining the effectiveness of antibiotics, it contributes to around 1.2 million worldwide deaths a year.

We’re using our expertise in developing prevention and treatment options to focus on pathogens that have the highest probability of developing AMR, as identified by the Centers for Disease Control (CDC) and the WHO.

## Progressing towards a new treatment for urinary tract infections and gonorrhoea

We are developing gepotidacin, a novel mechanism topoisomerase inhibitor, for uncomplicated UTs and gonorrhoea, in partnership with the Biomedical Advanced Research and Development Authority (BARDA) in the US. In early November, we received positive results from EAGLE-2 and EAGLE-3 phase III trials evaluating gepotidacin, in female adults and adolescents with uUTIs. Following a recommendation by the Independent Data Monitoring Committee (IDMC) we stopped the trials early for efficacy and plan to submit a New Drug Application to the FDA in 2023. We are also studying gepotidacin as a potential treatment for urogenital gonorrhoea (GC) in the EAGLE-3 phase III trial, with potential to read out in the second half of 2023.

In November 2022, we started a phase I/II study to evaluate the safety and efficacy of a new vaccine candidate for gonorrhoea prevention. This vaccine candidate, based on our proprietary GMMA (generalised modules for membrane antigens), aims at protecting adolescents and adults against gonorrhoea infections.

In 2022, we also started a phase Ib study of our first-in-class FimH antagonist, a novel molecule that blocks binding of E. coli bacteria to the bladder epithelium, as a treatment for recurrent urinary tract infection.

## Investigating our salmonella vaccine

In July 2022, we started a phase I study with the University of Oxford to investigate our candidate vaccine for invasive non-typhoidal salmonellosis (iNTS). The vaccine uses our generalised modules for membrane antigens (GMMA) technology. To explore its potential, we're partnering with Vacc-iNTS, a consortium of 12 partners from eight countries, including some where iNTS is endemic.



## HIV

In recent years, we’ve made breakthroughs in treating and preventing HIV to transform patients’ lives. We’re now building on these achievements with new products, including long-acting injectables which, for many, means significantly reducing therapy to just a few times a year.

HIV is one of the world’s biggest health threats, with 1.5 million new cases in 2021, including approximately 38,000 in the US. Around 38 million people were living with HIV worldwide in 2021, over half of them in sub-Saharan Africa.

In HIV, our work is through ViV Healthcare, the world’s only specialist HIV pharmaceutical company, which we majority own, with Pfizer and Shionogi as shareholders. Our goal is to treat, prevent and eventually cure HIV.

## Transforming the experience of patients living with HIV

With our portfolio of 17 antiretroviral medicines, we’re transforming the experience of people living with HIV. Instead of taking medicine orally every day, our Cabenuva (cabotegravir, rilpivirine) long-acting injectable regimen allows some patients to only have treatment six times a year. The treatment has established ViV Healthcare as the industry leader in long-acting HIV medicines.

Cabenuva is approved for dosing every two months in the US, and in Europe as the combination of Vocabria (cabotegravir) and Rekambys (rilpivirine). This combination received marketing approval in Japan in 2022, again for dosage every two months. The FDA has also approved a label update for Cabenuva that means patients no longer have to take cabotegravir and rilpivirine tablets for a month before starting Cabenuva injections.

ViV’s dolutegravir is the world’s most widely prescribed integrase inhibitor for HIV, taken by around 21 million people, or three out of four of those currently on HIV medications. It’s the foundation for Dovato and Juluca, our two-drug regimen oral therapies, which are as effective as three-drug regimens and allow people to take fewer drugs while still maintaining viral suppression.

## Working to prevent HIV

Preventing HIV is a central part of ViV Healthcare’s work. In late 2021, we received FDA approval for Apretude (cabotegravir), the first and only long-acting injectable pre-exposure prophylaxis (PrEP) option to reduce the risk of sexually acquired HIV-1. This approval was based on results from two pivotal phase III studies, HIV Prevention Trials Network (HPTN) 083 and 084, demonstrating superiority over the established standard of care.

In August 2022, we announced more data showing the continued superior efficacy of cabotegravir long-acting for PrEP over daily tablets. The unblinded portion of the HPTN 084 trial with women in sub-Saharan Africa showed a substantially lower rate of HIV acquisition.

## Offering a range of options for people living with HIV

We offer different medicines to meet the varying needs of people living with HIV.

Our portfolio of antiretrovirals also includes Trivicay and Triumeq, which contain dolutegravir. Triumeq now has US approval in a dispersible once-daily tablet formulation for children weighing 10kg and above and the Committee for Medicinal Products for Human Use (CHMP) of the EMA issued a positive opinion recommending marketing authorisation for Triumeq PD for children 14kg and above at the end of 2022. With 1.7 million children living with the virus, it’s important that this medicine, the first fixed-dose tablet regimen for children, is now available in a form that’s easier for them to take. The FDA has also lowered the minimum weight at which a child can be prescribed the Triumeq tablet from 40kg to 25kg.

Our commitment is to leave no person with HIV behind. That includes working to develop medicines for heavily treatment-experienced adults who have very few treatment options because of safety concerns, intolerance, or resistance. In 2022, we announced five-year data for Rukobia (fostemsavir), a first-in-class attachment inhibitor. In the ongoing BRIGHTE study, week 240 data shows that these patients can take fostemsavir as part of their antiretroviral regimen and keep their virus suppressed over the long term.

## Exploring more ways to improve the lives of people living with HIV

We’re exploring new types of long-acting therapy, based on cabotegravir, that could give people living with HIV the option to take medicine at home. These involve combining cabotegravir with other assets in our early-stage pipeline to create medicines that patients can administer themselves.

We’re also investigating ultra-long-acting medicines with dosing every three months or longer. Based on studies in 2022 and 2023, we will choose partners for cabotegravir and begin phase IIb and phase III studies of these combinations in 2024.

In October 2022, we announced positive phase IIa data for N6LS, a novel broadly neutralising antibody (bNAb). A study showed strong antiviral efficacy at two dosing levels. bNAbs can recognise different strains of HIV and stop them entering healthy cells, and so block the virus from replicating. They offer a potentially new approach to treatment and may help us combat treatment resistance in our efforts to end the HIV epidemic.

A European study of Vocabria (cabotegravir injection) and Rekambys (rilpivirine long-acting injectable suspension) showed the treatment was well received by people living with HIV and by clinic staff. In the CARISEL study, 81% of participants said the injectable treatment was less stigmatising than daily tablets, and the combination showed a high clinical effectiveness and a low rate of viral failure.



## Immunology/respiratory

For 50 years, we have been leaders in medicines that advance the management of asthma and chronic obstructive pulmonary disease (COPD), and we've sold products for respiratory problems since the 1880s. Now we draw on our expertise in the science of the immune system to develop medicines for immune-mediated conditions including lupus, eosinophilic-driven diseases such as severe eosinophilic asthma and other inflammatory diseases. Our innovative medicines help millions of people with immune and respiratory conditions.

## Widening access to Benlysta beyond systemic lupus erythematosus (SLE) to include lupus nephritis (LN)

SLE is a chronic autoimmune disease where the immune system mistakenly attacks healthy tissue in many parts of the body. It causes symptoms like swollen joints, fever, hair loss and facial rash, along with potential long-term complications including irreversible damage to vital organs like the heart and kidneys. SLE affects around five million people worldwide. LN, the kidney inflammation caused by lupus, can progress to kidney failure if left untreated. Approximately 40% of patients with SLE develop LN.

Our innovative research into the role of B cells in autoimmune conditions led to the development of Benlysta (belimumab), the only biologic approved for both SLE and LN. Benlysta is a monoclonal antibody that targets B-lymphocyte stimulator (BLyS), an underlying cause of SLE and LN, reducing autoantibody levels to help treat the short-term symptoms of inflammation and prevent irreversible damage to vital organs. In 2022, we received approval in China for Benlysta to treat adults with active LN. We also received FDA approval for Benlysta for paediatric patients with active LN. These followed earlier approvals for adult treatment in markets including EU member states, Japan and Brazil.

Our ambition is to improve outcomes for lupus patients with a ‘treat to target’ approach that aims for remission or reduced disease activity.

## Innovating to treat eosinophil-driven diseases

Eosinophil-driven diseases are associated with heightened levels of eosinophils, a type of white blood cell. Increased levels of eosinophils in the blood or tissue can cause a range of symptoms across a variety of conditions. When eosinophils infiltrate certain tissues, they can cause inflammation and organ damage which, over time, can affect patients' day-to-day life.
Eosinophil-driven diseases are associated with poor symptom control such as worsening asthma, and can cause breathing difficulties and interfere with taste, smell and sleep.

Our first-in-class monoclonal antibody Nucala (mepolizumab), targets interleukin-5 (IL-5) to reduce the number of eosinophils. It’s the only treatment in the US and Europe with indications across four eosinophilic diseases, including severe eosinophilic asthma (SEA), chronic rhinosinusitis with nasal polyps (CRSwNP), eosinophilic granulomatosis with polyangiitis (EGPA) and hypereosinophilic syndrome (HES).

In 2022 Nucala was approved in the US, Japan and Europe as a 40mg pre-filled syringe for 6-11-year-olds with SEA. The pre-filled syringe allows healthcare professionals or caregivers to administer Nucala at home. Previously, children could only receive the medicine in hospitals or physicians' offices, as pre-filled syringes were only available in adult strength.

We also continue to develop a new monoclonal antibody, depemokimab, under development for its high affinity and long-acting suppression of IL-5 function. Current IL-5 inhibitors are dosed every four weeks or every eight weeks. Depemokimab is designed to be administered every six months, which means it has the potential to be the first biologic to deliver ultra-long-acting treatment for patients with SEA. In 2022, we began phase III trials of depemokimab for CRSwNP, EGPA and HES, following initiation of trials in SEA in 2021.

## Otilimab

Data from the ContRAst programme examining otilimab as a potential treatment for rheumatoid arthritis showed limited efficacy and did not support a suitable benefit/risk profile. As a result, we decided not to progress with regulatory submissions.

## Other clinical advances

We moved two antibodies from phase I to phase II: anti-CCL17 – a novel anti-cytokine antibody for pain in both osteoarthritis and diabetic peripheral neuropathy, representing a novel non-opioid, non-NSAID analgesic therapy; and anti-IL18 – a novel anti-cytokine antibody for atopic dermatitis which was identified with the use of human genetics and human translational studies.



## Oncology

Cancer remains a leading cause of death with unmet patient need. We have an emerging portfolio in oncology and will develop programmes using the science of the immune system with human genetics and new technology.

In oncology, we take a balanced and pragmatic approach to investment in our research areas of immuno-oncology, tumour cell-targeting therapies and synthetic lethality. We have 11 investigational medicines in our oncology pipeline that have the potential to make a meaningful difference for patients with cancer.

We also grow our oncology pipeline through targeted business development with acquisitions and collaborations. In 2022, we acquired Sierra Oncology, a biopharmaceutical company focused on therapies for rare forms of blood cancer, such as myelofibrosis. We also entered into an exclusive global licence option agreement with Mersana in a range of HER2-expressing tumours, such as breast, gastric and non-small-cell lung cancers, and an expanded global, non-exclusive licence and collaboration agreement with SpringWorks Therapeutics for multiple myeloma. In 2022, we also expanded our existing collaboration with precision medicine partner Tempus, with an initial focus in oncology (see page 19).

## Positive readouts for Jemperli

Colorectal cancer is the third most common form of cancer, with over 1.9 million new cases in 2020. We’re exploring an immunotherapy treatment with curative intent using Jemperli (dostarlimab) in a subset of rectal cancer. At ASCO 2022 breakthrough findings were presented and published in The New England Journal of Medicine by researchers at Memorial Sloan Kettering Cancer Center (MSK) confirming a clinical complete response in all 14 patients who received treatment with Jemperli as a neoadjuvant treatment for mismatch repair-deficient locally advanced rectal cancer. In February 2023 the FDA Oncologic Drugs Advisory Committee (ODAC) voted 8 to 5 that the two proposed single-arm trials would be sufficient to characterise the benefits and risks of Jemperli in the curative-intent setting for patients with mismatch repair-deficient/microsatellite instability-high locally advanced rectal cancer.
In late 2022, our phase II PERLA study comparing Jemperli plus chemotherapy to pembrolizumab plus chemotherapy for metastatic non-squamous non-small-cell lung cancer returned positive data. The results support our ambition for Jemperli to be the backbone of our immuno-oncology programme, either alone or combined with standard of care and novel cancer therapies, especially for patients with limited treatment options.

Our phase III COSTAR trial is studying Jemperli in combination with cobalimab, an investigational selective anti-TIM-3 monoclonal antibody, and chemotherapy in patients with advanced non-small-cell lung cancer who have progressed on anti-PD-(L)1 therapy and chemotherapy. The combination has the potential to be the first of its kind.

## CD226 axis

Our work focused in immuno-oncology aims to help the immune system recognise and kill cancer cells more effectively. We’re investigating how Jemperli, in combination with novel assets targeting the CD226 axis, can support anti-tumour activity.

We are the only company with access to antibodies targeting all three checkpoints on the CD226 axis, including PVRIG, TIGIT and CD96. We’re executing a comprehensive development plan that will combine these investigational antibodies with Jemperli, in both doublet and triplet therapies. In addition to several early phase trials that are underway, our phase II platform study in first-line non-small-cell lung cancer began dosing patients with an initial combination of Jemperli and our TIGIT antibody, partnered with iTeos Therapeutics.

## Gynaeologic and breast cancers

In 2020, nearly 1.4 million women around the world were diagnosed with a gynaeologic cancer.

We continue to explore the potential for our existing treatments to advance the standard of care for hard-to-treat gynaeologic cancers, both alone and in combination with each other and other agents. In second-line endometrial cancer, the FDA granted full approval for Jemperli in February 2023 for the treatment of adult patients with mismatch repair-deficient (dMMR) recurrent or advanced endometrial cancer, as determined by an FDA-approved test, that has progressed on or following a prior platinum-containing regimen in any setting and are not candidates for curative surgery or radiation.



## Research and development continued

In December 2022, we announced positive headline results from the planned interim analysis, or Part 1, of our RUBY phase III trial investigating Jemperli in combination with chemotherapy as a frontline treatment for advanced or recurrent endometrial cancer. It showed a statistically significant and clinically meaningful progression-free survival (PFS) benefit in the prespecified dMMR/MSI-H patient subgroup and in the overall population. In Part 2 of the RUBY study, we will assess Jemperli in combination with Zejula in the same setting, with initial results anticipated in the second half of 2023. Our FIRST trial, is evaluating this combination as a potential new first-line maintenance therapy for ovarian cancer with results expected in the second half of 2023. \( ^{1} \) 

Our phase III trial, ZEST I, is exploring the efficacy and safety of Zejula (niraparib) as an early-stage treatment for breast cancer. The trial uses circulating tumour DNA technology for the first time in a pivotal breast cancer study. This offers the potential to detect tumour cells earlier at the molecular level and identify women at higher risk of recurrence. This means therapy with Zejula could start when the burden of disease is still low and may create an opportunity to slow or stop the cancer’s progress more effectively.

## Investigating Zejula for lung cancer

We’re evaluating Zejula in our phase III ZEAL lung cancer trial, which is investigating Zejula as a first-line maintenance therapy for patients with advanced non-small-cell lung cancer (squamous and non-squamous histologies), after they have received platinum-based chemotherapy. The trial is studying the efficacy and safety of Zejula in combination with the standard of care treatment.

## Blood cancers

Myelofibrosis is a rare blood cancer that affects around 20,000 patients in the US, most of whom either have anaemia when they’re diagnosed or develop it eventually. Patients often need transfusions, and around 30% stop treatment because of anaemia.

Momelotinib may address the significant medical needs of myelofibrosis patients with anaemia by reducing dependence on transfusions while still treating other symptoms of the disease and enlarged spleen.

A New Drug Application and Marketing Authorisation Application for momelotinib is currently under review with the FDA and EMA, respectively. Momelotinib is not currently approved in any market. We anticipate a US launch in 2023.
Multiple myeloma is the world’s third most common blood cancer, with more than 175,000 people developing it every year. Blenrep (belantamab mafodotin) is for patients with relapsed or refractory multiple myeloma who have received at least four other therapies.

Blenrep is approved in Europe and Hong Kong. Our DREAMM trials are investigating its potential in earlier lines of treatment, together with standard and novel therapies, as well as exploring dosing and scheduling modifications.

In November 2022, we announced we would withdraw Blenrep from the US market following the request of the FDA. This request was based on the outcome of the DREAMM-3 confirmatory trial, which did not meet the requirements of the FDA Accelerated Approval regulations. Other trials in the DREAMM clinical trial programme will continue. They are designed to demonstrate the benefit of Blenrep in combination with novel therapies and standard-of-care treatments in earlier lines of therapy and dosing optimisation to maintain efficacy while reducing corneal events. We anticipate data from the DREAMM-7 and DREAMM-8 phase III trials in the second half of 2023.

## Early science and other collaborations

In 2022, we announced an exclusive global licence option agreement to co-develop and commercialise Mersana Therapeutics' XMT-2056 immunosyn them anti-body-drug conjugate that targets a novel epitope of HER2. It's designed to activate the innate immune system through STING signalling in immune cells in tumours, and tumour cells themselves. Mersana has initiated a phase I clinical trial of XMT-2056 to investigate its potential in a range of HER2-expressing tumours, such as breast, gastric, colorectal and non-small-cell lung cancers. The FDA has granted an orphan drug designation to XMT-2056 for the treatment of gastric cancer.

Additionally, to further enhance our tumour-cell targeting portfolio, we entered into an agreement with WuXi Biologics for exclusive licences for up to four bi- and multi-specific T-cell engaging (TCE) antibodies developed using WuXi Biologics' proprietary technology platforms. This deal allows us to access potential best-in-class TCE antibodies that have been optimised for effective tumor killing with a desirable safety profile.



## Opportunity driven

As well as our portfolio across therapy areas, we pursue other opportunities where the emerging science indicates the potential for important new opportunities to have major impact in addressing unmet need.

## Transforming the treatment of anaemia with
daprodustat

Over 700 million people suffer from chronic kidney disease (CKD) worldwide, and an estimated one in seven of them has anaemia. For many, the treatment options are limited. When left untreated or undertreated, anaemia of CKD is associated with poor clinical outcomes and leads to a substantial burden on patients and healthcare systems.

Daprodustat is our oral treatment in a class of medicines called oral hypoxia-inducible factor prolly hydroxylase inhibitors (HIF-PHIs). It's based on human genetics and Nobel Prize-winning science showing how cells sense and adapt to oxygen availability. Daprodustat offers a potentially easier oral treatment than the current injection-based standard of care, while still managing haemoglobin levels effectively. It's approved as Duvrog in Japan.

In October 2022, we reported that the FDA Cardiovascular and Renal Drugs Advisory Committee (CRDAC) supported that the benefit of treatment with daprodustat outweighs the risks for adult dialysis patients with anaemia of CKD with a 13 to 3 vote. In adult non-dialysis patients with anaemia of CKD, the CRDAC did not support that the benefit of treatment with daprodustat outweighs the risks with a 5 to 11 vote.

On 1 February 2023, the FDA approved daprodustat under the name Jesduvrog for the treatment of anaemia of chronic kidney disease in adults on dialysis. In March 2022, the EMA validated the marketing authorisation application for daprodustat, which is currently under regulatory review with a decision anticipated mid-2023.
Progressing towards a new treatment for cholestatic pruritus in primary biliary cholangitis
Linerixibat is our ileal bile acid transporter (IBAT) inhibitor to potentially treat cholestatic pruritus in patients with primary biliary cholangitis (PBC). This is a rare autoimmune liver disease affecting approximately 15 per 100,000 people. Significant numbers of PBC patients suffer with cholestatic pruritus, a debilitating itch, and there has been no new pharmacologic therapy in this area in 60 years.

Our development programme demonstrates how we are using digital technology to modernise drug development, using novel platforms to run our studies with the potential to increase trial diversity. An example of this is a new decentralised clinical trial (DCT) design with the potential to improve patient recruitment and retention in GLISTEN, the phase III trial of linerixibat for cholestatic pruritus in patients with PBC. This is an emerging trial model where assessment of patients can occur at a patient’s own home, improving accessibility for patients who may not live near to a specialist. This is a first and we expect this innovation to continue.

Linerixibat has received Orphan Drug Designation in Europe and the US.



## Research and development continued

## Pipeline overview

We have 69 assets in development, of which 18 are late-stage.

<table><tr><td>Phase III/Registration</td></tr><tr><td>Bexsero infants US (recombinant protein) MenB</td></tr><tr><td>SKYCovione (SK Bioscience) \( ^{1} \)  COVID-19 \( ^{4} \)</td></tr><tr><td>3536819 (conjugated, recombinant protein) MenABCWY</td></tr><tr><td>1st gen</td></tr><tr><td>3844766 \( ^{1} \)  (recombinant protein) \( ^{3} \)  RSV older adults</td></tr><tr><td>gepotidacin \( ^{1} \)  (BTI inhibitor) uUTI and GC</td></tr><tr><td>bepirovirsen \( ^{1} \)  (HBV ASO) HBV</td></tr><tr><td>tebipenem pivoxil \( ^{1} \)  (antibacterial carbapenem) cUTI \( ^{10} \)</td></tr><tr><td>Xevudy \( ^{1} \)  (sotrovimab/VIR-7831 monoclonal antibody)</td></tr><tr><td>COVID-19</td></tr><tr><td>Blenrep \( ^{1} \)  (anti-BCMA ADC) multiple myeloma</td></tr><tr><td>Jemperli \( ^{1} \)  (anti-PD-1) IL endometrial cancer \( ^{2} \)</td></tr><tr><td>Zejula \( ^{1} \)  (PARP inhibitor) ovarian, lung and breast cancer</td></tr><tr><td>molemotinib \( ^{1} \)  (JAK1, JAK2 and ACVR1 inhibitor) myelofibrosis</td></tr><tr><td>cobolimab \( ^{1} \)  (anti-TIM-3) NSCLC</td></tr><tr><td>Iatozinemab \( ^{1} \)  (AL001, anti-sortilin) frontotemporal dementia \( ^{2,9} \)</td></tr><tr><td>depemokimab \( ^{1} \)  (LA anti- IL5) asthma \( ^{2} \)</td></tr><tr><td>Nucala (anti-IL5) COPD</td></tr><tr><td>daprodustat (HIF-PHI) anaemia of chronic kidney disease \( ^{12} \)</td></tr><tr><td>linerixibat (IBAT inhibitor) cholestatic pruritus in primary biliary cholangitis</td></tr><tr><td>Phase II</td></tr><tr><td>3437949 \( ^{1} \)  (recombinant protein) \( ^{3} \)  malaria fractional dose</td></tr><tr><td>4406371 (live, attenuated) MMRV new strain</td></tr><tr><td>3536852 \( ^{1} \)  (GMMA) Shigella</td></tr><tr><td>3528869 \( ^{1} \)  (viral vector with recombinant protein) \( ^{3} \)</td></tr><tr><td>therapeutic HBV \( ^{6} \)</td></tr><tr><td>4023393 (conjugated, recombinant protein) MenABCWY</td></tr><tr><td>2nd gen \( ^{6} \)</td></tr><tr><td>4178116 (live, attenuated) varicella new strain</td></tr><tr><td>5101955 \( ^{1} \)  (MAPS) pneumococcal 24-valent - paediatric</td></tr><tr><td>5101956 \( ^{1} \)  (MAPS) pneumococcal 24-valent - adults</td></tr><tr><td>4106647 \( ^{1} \)  (protein-adjuvant) \( ^{3} \)  HPV \( ^{6} \)</td></tr><tr><td>3036656 \( ^{1} \)  (leucyl t-RNA inhibitor) tuberculosis</td></tr><tr><td>sanfetrinen cilexetil \( ^{1} \)  (serine beta lactamase inhibitor) tuberculosis</td></tr><tr><td>BVL-GSK098 \( ^{1} \)  (ethionamide booster) tuberculosis</td></tr><tr><td>VIR-2482 \( ^{1} \)  (neutralising monoclonal antibody) \( ^{5} \)  influenza</td></tr><tr><td>3640254 (maturation inhibitor) HIV \( ^{13} \)</td></tr><tr><td>3810109 \( ^{1} \)  (broadly neutralising antibody) HIV</td></tr><tr><td>4428859 \( ^{1} \)  (anti-TIGIT) cancer</td></tr><tr><td>Benlysta (anti-BLyS) Systemic sclerosis associated interstitial lung disease \( ^{10} \)</td></tr><tr><td>4532990 \( ^{1} \)  (HSD17B13 siRNA) non-alcoholic steatohepatitis \( ^{10} \)</td></tr></table>

<table><tr><td>Phase I</td></tr><tr><td>2904545 \( ^{1} \)  (recombinant protein) \( ^{3} \)  C. difficile</td></tr><tr><td>4429016 \( ^{1} \)  (bioconjugated, recombinant protein) \( ^{3} \)  K. pneumoniae</td></tr><tr><td>3993129 (recombinant subunit) \( ^{3} \)  CMV \( ^{6} \)</td></tr><tr><td>4382276 \( ^{1} \)  (mRNA) flu</td></tr><tr><td>4396687 \( ^{1} \)  (mRNA) COVID-19</td></tr><tr><td>4077164 \( ^{1} \)  (bivalent GMMA) iNTS (typhimurium + enteritidis) \( ^{2} \)</td></tr><tr><td>3943104 \( ^{1} \)  (recombinant protein) \( ^{3} \)  Therapeutic HSV</td></tr><tr><td>4348413 (GMMA) gonorrhoea \( ^{6} \)</td></tr><tr><td>3536867 \( ^{1} \)  (bivalent conjugate) Salmonella (typhoid + paratyphoid A)</td></tr><tr><td>2556286 \( ^{1} \)  (Mtb inhibitor) tuberculosis</td></tr><tr><td>3186899 \( ^{1} \)  (CRK-12 inhibitor) visceral leishmaniasis \( ^{7} \)</td></tr><tr><td>3494245 \( ^{1} \)  (proteasome inhibitor) visceral leishmaniasis</td></tr><tr><td>3772701 \( ^{1} \)  (P falciparum whole cell inhibitor) malaria</td></tr><tr><td>3882347 \( ^{1} \)  (FimH antagonist) uUTI</td></tr><tr><td>3923868 (PI4k \( ^{8} \)  inhibitor) viral COPD exacerbations</td></tr><tr><td>4182137 \( ^{1} \)  (VIR-7832 monoclonal antibody) COVID-19 \( ^{6} \)</td></tr><tr><td>3965193 (PAPD5/7 inhibitor) HBV</td></tr><tr><td>5251738 \( ^{1} \)  (TLR8 agonist) HBV</td></tr><tr><td>3739937 (maturation inhibitor) HIV</td></tr><tr><td>cabotegravir (400 mg/ml formulation) HIV</td></tr><tr><td>4004280 (capsid protein inhibitor) HIV</td></tr><tr><td>4011499 (capsid protein inhibitor) HIV</td></tr><tr><td>4524184 \( ^{1} \)  (integrase inhibitor) HIV</td></tr><tr><td>3745417 (STING agonist) cancer</td></tr><tr><td>4074386 \( ^{1} \)  (anti-LAG3) cancer</td></tr><tr><td>6097608 \( ^{1} \)  (anti-CD96) cancer</td></tr><tr><td>4381562 \( ^{1} \)  (anti-PVRIG) cancer</td></tr><tr><td>XMT-2056 \( ^{11} \)  (STING agonist ADC) cancer (wholly owned by Mersana Therapeutics)</td></tr><tr><td>4527226 \( ^{1} \)  (AL101, anti-sortilin) neurodegenerative diseases</td></tr><tr><td>3858279 \( ^{1} \)  (anti-CCL17) osteoarthritis pain</td></tr><tr><td>1070806 (anti-IL18) atopic dermatitis</td></tr><tr><td>3888130 \( ^{1} \)  (anti-IL7) multiple sclerosis</td></tr><tr><td>4172239 \( ^{1} \)  (DNMT1 inhibitor) - sickle cell disease \( ^{8} \)</td></tr></table>

Only the most advanced indications are shown for each asset.

1 In-licence or other alliance relationship with third party

2 Additional indications or candidates also under investigation

3 Adjuvanted

4 GSK contributing pandemic adjuvant

5 GSK has exclusive option to co-develop post phase II

6 In phase I/II study

7 Transition activities underway to enable further progression by partner
8 Imminent study start

9 Phase III trial in patients with progranulin gene mutation

10 Phase II or III study start expected in 2023

11 GSK has an exclusive global license option to co-develop and commercialise the candidate

12 FDA approved in February 2023

13 Will not progress to phase III

MenB: meningitis B; RSV: respiratory syncytial virus; uUTI: uncomplicated urinary tract infection; GC: urogenital gonorrhoea; HBV: hepatitis B virus; cUTI: complicated urinary tract infection; ADC: Antibody drug conjugate NSCLC: non-small cell lung cancer; LA: long-acting ;COPD: chronic obstructive pulmonary disease; MMRV: measles, mumps, rubella & varicella; HSV: herpes simplex virus; siRNA: small interfering RNA; HPV: human papillomavirus; MAPS: multiple antigen presenting system; CMV: cytomegalovirus; GMMA: generalised modules for membrane antigens; iNTS: invasive non-typhoidal salmonella; ASO: antisense oligonucleotide



# Commercial operations
Performance: Vaccines

Our broad vaccines portfolio targets infectious diseases at every stage of life, helping to protect people from meningitis, shingles, flu, polio and many more.






## Performance: Vaccines

Turnover
£7.9bn
+17% AER, +11% CER



● Established £3,085m
● Shingles £2,958m
● Meningitis £1,116m
● Influenza £714m
● Pandemic £64m

Key products

<table><tr><td>Product</td><td>Disease</td><td>Total revenue</td><td>Key information</td></tr><tr><td>Shingrix</td><td>Herpes zoster (shingles)</td><td>£2,958m +72% AER; +60% CER</td><td>Record sales year. Now launched in 26 markets</td></tr><tr><td>Bexsero</td><td>Meningitis group B</td><td>£753m +16% AER; +12% CER</td><td>Approved in France for National Immunisation Programme in 2022. Now available in 50 markets</td></tr><tr><td>Fluarix, FluLaval</td><td>Seasonal influenza</td><td>£714m +5% AER; -4% CER</td><td>Joint first to market with Sanofi in US enabling vaccinations to begin in July 2022</td></tr><tr><td>Boostrix</td><td>Diphtheria, tetanus, acellular pertussis booster</td><td>£594m +14% AER; +7% CER</td><td>US approval for maternal immunisation indication in 2022</td></tr><tr><td>Infanrix, Pediarix</td><td>Diphtheria, tetanus, pertussis, polio, hepatitis B, haemophilus influenza type B</td><td>£594m +9% AER; +3% CER</td><td>Pediarix leads in the US in market share by volume</td></tr><tr><td>Energix, Twirrix, Havrix</td><td>Hepatitis</td><td>£571m +24% AER; +16% CER</td><td>Travel and routine immunisation for hepatitis recovering as expected in 2022</td></tr><tr><td>Rotarix</td><td>Rotavirus</td><td>£527m -3% AER; -3% CER</td><td>Rotarix fully liquid in the US and approved in France for National Immunisation Programme in 2022</td></tr><tr><td>Menveo</td><td>Meningitis group A, C, W and Y</td><td>£345m +27% AER; +18% CER</td><td>Menveo fully liquid in the US and Brazil in 2022</td></tr><tr><td>Synflorix</td><td>Invasive disease, pneumonia, acute otitis media</td><td>£305m -15% AER; -15% CER</td><td>Affinivax acquisition for next-generation PCV of 24 valents and greater</td></tr><tr><td>Priorix, Priorix Tetra, Varilrix</td><td>Measles, mumps, rubella and chickenpox</td><td>£188m -28% AER; -29% CER</td><td>US approval for Priorix in 2022 supporting continued expansion of our established portfolio</td></tr><tr><td>Cervarix</td><td>Human papilloma virus</td><td>£117m -15% AER; -20% CER</td><td>China approval for a two-dose schedule in 2022</td></tr></table>

## Sales performance

We achieved strong growth in vaccines in 2022, driven by record sales for our shingles vaccine, and continued geographic expansion of our meningitis vaccine.

Vaccines turnover was £7,937 million, up 17% at AER, 11% at CER in total, and up 24% at AER, 17% at CER excluding pandemic adjuvant sales. The performance reflected a favourable comparator, which was impacted by COVID-19 related disruptions in several markets primarily in H1 2021, and strong commercial execution of Shingrix, particularly in the US and Europe.

Shingrix sales grew 72% at AER, 60% at CER to £2,958 million. All regions grew significantly reflecting post-pandemic rebound, strong uptake and new market launches with more than half of the growth contributed from outside of the US. In the US, Shingrix grew 46% at AER, 32% at CER to £1,964 million due to higher non-retail and retail demand and strong commercial execution. Germany and China contributed strongly to the Shingrix growth. Shingrix was launched in nine markets during 2022 and is now available in 26 countries.
Meningitis vaccines sales grew 16% at AER, 11% at CER to £1,116 million mainly driven by Bexsero up 16% at AER, 12% at CER to £753 million resulting from higher CDC demand and increased share in the US. Menveo sales were also up 27% AER, 18% CER to £345 million, primarily driven by post-pandemic vaccination catch-up and higher public demand in International, together with favourable pricing mix and share gain in the US.

Fluarix/FluLaval sales grew by 5% AER but decreased 4% CER to £714 million, primarily driven by lower post-pandemic demand in Europe and the US, partly offset by lower expected returns in the US.

Established Vaccines grew 4% AER but was stable at CER to £3,085 million mainly resulting from supply constraints in MMR/V vaccines and lower tender demand in International for Synflorix. This was offset by hepatitis vaccines demand rebound in the US and Europe and Boostrix post-pandemic demand recovery and increased share in the US.



## Performance: Vaccines continued

Pandemic vaccines decreased 86% AER and CER primarily reflecting comparison to 2021 pandemic adjuvant sales to the US and Canadian governments partly offset by GSK’s share of 2022 contracted European volumes related to the COVID-19 booster vaccine developed through a collaboration with Sanofi Pasteur (Sanofi).

## Our strategy for growth

Vaccines play a critical role in our growth. We aim to reach 1.3 billion people with vaccines by 2031, a significant contribution to our overall ambition to positively impact the health of 2.5 billion people. We will achieve this through growth of our existing adult and paediatric vaccines and new launches. Our focus is on accelerating the vaccines pipeline, particularly RSV and MenABCWY, ensuring manufacturing capability and capacity for RSV, Shingrix and our established portfolio, and entering new markets. We also prioritise targeted business development which complements our existing vaccine portfolio and gives us access to new patients.

Vaccines are complex and highly technical both to develop and manufacture. As such there is no established generic industry and they therefore do not generally face the so-called 'patent cliff'. This longer lifecycle means that vaccines can remain in use for decades after their initial authorisation. For example Boostrix, Infanrix, Priorix and Engerix are beyond their patents but remain important parts of our portfolio in terms of contribution to performance. And importantly, our vaccines have a strong efficacy profile with 90% of our portfolio by sales having an efficacy level of above 90% – helping to protect our portfolio from potential disruption from new technologies.

Our portfolio of more than 20 marketed vaccines is one of the industry’s broadest, helping to protect people throughout their lives against diseases, including meningitis, shingles, flu, polio, measles and many more. We deliver one and a half million doses of our vaccines every day; and around 40% of the world’s children receive a GSK vaccine each year.

The full benefits of vaccination go beyond the health of individuals. Vaccination programmes help minimise health inequity and reduce costs to the healthcare system, potentially promoting economic growth and societal wellbeing. With our acquisition of Affinivax and, if we get approval, the future launch of our RSV vaccine for older adults, we are well positioned in the adult vaccination segment, which will be a key growth driver of the global vaccines market.
Our established platform technologies, and the new platforms we’re building, such as the MAPS and mRNA technologies, are a key part of our vaccines growth strategy and are enabling us to tackle the most complex diseases from birth throughout adulthood (see page 19).

## Drivers of growth across the portfolio

Record annual sales for Shingrix were driven by strong demand in existing markets and geographic expansion. Shingrix continues to be recommended for adults and at-risk groups in countries around the world, driving its uptake. By 2024, we aim to have launched in 35 markets which make up about 90% of the vaccine market by value.

We continue to strengthen our leadership position in meningitis vaccines with an aim to double sales by 2031 through continued market share growth, the geographic expansion of Bexsero and the anticipated launch of our pentavalent vaccine. During the year, France approved Bexsero for its National Immunisation Programme and we also launched Bexsero in Taiwan and received marketing authorisation in South Korea, making Bexsero available in a total of 50 countries.

We remain committed to growing our established portfolio, which represents about half of our total vaccines business. We continue to seek to expand the availability of our vaccines in markets around the world; our lifecycle management strategy has strengthened our presence in the US. For example, Priorix, our measles, mumps and rubella vaccine, has been protecting people worldwide for 25 years; its launch in the US this year underscores how it remains an important part of our established portfolio. Also in the US, we received FDA approval for fully liquid formulations of Rotarix, our rotavirus vaccine and Menveo, our meningitis ACWY vaccine. We were also first to receive FDA approval for a vaccine given in pregnancy, Boostrix maternal, which can be administered in the third trimester to help prevent whooping cough in young babies (see page 22).



## Performance: Vaccines continued

## Meeting the needs of healthcare professionals and patients (HCPs)

From the age of about 50, our immune system starts to decline and becomes less effective, leading to increased vulnerability to infectious diseases. Given this, we are focusing our efforts on helping to keep older adults healthy. We want to improve physician-patient dialogue on vaccination, to raise awareness in adults of vaccine-preventable diseases and to increase access to vaccination beyond the physician's office.

Our Vaccine Study 2022 Report explored attitudes and beliefs of HCPs and those over 50 years to vaccination. The study showed that HCPs are a patient's number one source of information about vaccines. But HCPs can't always meet their patients' needs because they lack time, want to avoid conflict or don't have enough information and training.

To ease some of the pressure on HCPs, we've started a digital channel partnership with NextDoor in the US, providing vaccination information directly to patients. We've also launched a consumer campaign about the importance of vaccination. We're working directly with HCPs through a series of Vaccinology Master Classes, helping to better equip them for conversations with their patients about vaccines.

With US research company IQVIA, we also launched Vaccine Track, a data platform to help improve adult vaccination nationwide. The platform gives HCPs information about the uptake of recommended adult immunisations. With this data, HCPs can target their efforts to increase discussion about vaccination and improve coverage in areas showing a relative decline in immunisation.

We're working with expert groups on adult vaccination calendars which show HCPs and their patients which vaccines they're eligible for.

In 2022, we launched a first-ever shingles awareness week with the International Federation on Ageing, reaching more than 900 million people globally. Such campaigns remain an important way of increasing awareness of vaccine preventable diseases, prompting patients to seek HCP guidance on next steps, including preventative options.

Globally, governments, policymakers and healthcare providers are recognising the potential advantages of having increased access to vaccination through additional channels such as vaccination centres as well as retail pharmacies. We're working with pharmacy chains to provide information for patients as they consider their vaccination options.

## Strengthening our manufacturing network to support vaccines growth

In 2022, our 12 manufacturing sites in nine countries produced and delivered over 500 million vaccine doses. This was despite supply challenges with incoming materials and shipping impacts caused by COVID-19, the global economic environment and the conflict in Ukraine.

Our sites are routinely inspected by multiple regulatory agencies. In 2022, there were 45 inspections by health authorities across our manufacturing sites.

We are preparing our manufacturing and supply capabilities to support both our inline product growth and our pipeline products pending approval. This includes our RSV vaccine for older adults. In 2022, the RSV production facility in Wavre, Belgium, produced the first doses for the market at a 100% success rate. To be ready for demand, we announced a €70 million investment in a second manufacturing facility for RSV antigen production in Belgium. Also in Belgium, we invested in more capacity for lyophilised products as well as building our internal mRNA capabilities. Following the acquisition of Affinivax, we are adding MAPS to our production technology platforms by using capabilities at our Singapore site as well as new investments at GSK Binney Street in Cambridge, Boston.

Overall, we're focused on increasing the control and robustness of our supply chain. A good example of this is the manufacturing of key adjuvants (AS01, AS03). We've brought production of MPL and QS21 (components of AS01) in-house at Hamilton. We've also formulated over 200 batches of adjuvant in Belgium since 2020 for current and future key assets such as Shingrix, Mosquirix or our RSV candidate vaccine for older adults.

Throughout the year we invested in modernising, digitising and automating our manufacturing network. For example, our quality control laboratories at all our sites went completely paperless. We’ll transition more than 50 production lines at 10 sites to electronic batch records by 2025 as we build on our digital capability for better operational efficiency, compliance, yield and shorter lead times.



## Commercial operations
Performance: Specialty Medicines

We continue to be global leaders in HIV medicines, focus on pioneering treatments for immune-mediated conditions and respiratory diseases, and have an emerging portfolio of cancer medicines.






## Performance: Specialty Medicines

Turnover

£11.3bn

+37% AER, +29% CER



HIV £5,749m

Immuno-inflammatory, respiratory and other £2,609m

Pandemic £2,309m

Oncology £602m

## Sales performance

Specialty Medicines sales were £11,269 million, up 37% at AER, 29% at CER, driven by consistent double-digit growth in all therapy areas. Specialty Medicines, excluding sales of Xevudy, were £8,960 million up 23% at AER, 15% at CER.

HIV sales were £5,749 million with growth of 20% at AER, 12% at CER. The performance benefited from strong patient demand for the new HIV medicines (Dovato, Cabenuva, Juluca, Rukobia and Apretude), which contributed approximately three quarters of the growth. US pricing favourability and year-end inventory build together contributed one third of the growth which was partially offset by International tender decline.

Key marketed products

<table><tr><td>Product</td><td>Disease</td><td>Total revenue</td><td>Key information</td></tr><tr><td>Xevudy</td><td>COVID-19 treatment</td><td>£2,309m  \( \times $  100% AER;  \( \times $ 100% CER</td><td>Monoclonal antibody treatment. Delivered more than two million doses to over 30 countries since approval</td></tr><tr><td>Triumeq</td><td>HIV treatment</td><td>£1,799m -4% AER; -11% CER</td><td>Dolutegravir-based fixed dose combination tablets. Marketed in 67 countries</td></tr><tr><td>Nucala</td><td>Respiratory eosinophil-driven diseases</td><td>£1,423m +25% AER; +18% CER</td><td>The only treatment to be indicated in the US and Europe for use across four eosinophil-driven diseases (see page 24)</td></tr><tr><td>Tivicay</td><td>HIV treatment</td><td>£1,381m flat% AER; -7% CER</td><td>Dolutegravir tablet for use in combination with other antiretroviral agents. Marketed in 71 countries</td></tr><tr><td>Dovato</td><td>HIV treatment</td><td>£1,375m +75% AER; +65% CER</td><td>Dolutegravir based two-drug regimen. Now launched in over 50 markets</td></tr><tr><td>Benlysta</td><td>Lupus and lupus nephritis</td><td>£1,146m +31% AER; +20% CER</td><td>Only biologic approved to treat both SLE and LN, in the US, Europe and elsewhere</td></tr><tr><td>Juluca</td><td>HIV treatment</td><td>£636m +23% AER; +14% CER</td><td>Dolutegravir based two-drug regimen. Marketed in 30 countries</td></tr><tr><td>Zejula</td><td>Ovarian cancer</td><td>£463m +17% AER; +12% CER</td><td>PARP inhibitor commercially available in 1L maintenance in 29 markets and in 2L maintenance in 29 markets</td></tr><tr><td>Cabenuva (Vocabria + Rekambys in Europe and Japan)</td><td>HIV treatment</td><td>£340m  \( \times $  100% AER;  \( \times $ 100% CER</td><td>First and only complete long-acting injectable regimen (cabotegravir, rilpivirine). Launched in over 20 countries</td></tr><tr><td>Blenrep</td><td>Blood cancer - multiple myeloma</td><td>£118m +33% AER; +25% CER</td><td>An antibody-drug conjugate commercially available in 19 countries for patients with relapsed or refractory multiple myeloma</td></tr><tr><td>Rukobia</td><td>HIV treatment</td><td>£82m +82% AER; +64% CER</td><td>Extended-release tablets for people living with multi-drug resistant HIV-1 for use in combination with other antiretrovirals. Approved in the US, Canada and Europe</td></tr><tr><td>Apretude</td><td>HIV prevention</td><td>£41m</td><td>First and only long-acting injectable (cabotegravir) for HIV prevention. Launched in the US in 2022</td></tr><tr><td>Jemperli</td><td>Endometrial cancer</td><td>£21m  \( \times $  100% AER;  \( \times $ 100% CER</td><td>PD-1-blocking antibody available in 15 countries that is continuing to be investigated for future monotherapy and combination regimens in multiple tumour types</td></tr></table>

New HIV products delivered sales of over two billion to £2,474 million, up 78% at AER, 67% at CER, representing 43% of the total HIV portfolio compared to 29% last year. Growth was primarily driven by sales of Dovato and Cabenuva. Dovato recorded sales of £1,375 million up 75% at AER and 65% at CER and Cabenuva recorded sales of £340 million. Apretude delivered sales of £41 million.

Immuno-inflammatory, Respiratory and Other sales were £2,609 million up 29% at AER, 20% at CER on strong performance of Benlysta and Nucala. Benlysta sales were £1,146 million, up 31% at AER, 20% at CER, representing strong underlying demand in US and worldwide. Nucala sales were £1,423 million, up 25% at AER, 18% at CER, reflecting continued strong patient demand and the launch of additional indications.



## Performance: Specialty Medicines continued

Oncology sales were £602 million, up 23% at AER, 17% at CER. Zejula sales of £463 million were up 17% at AER, 12% at CER driven by the first-line indication, but with diagnosis and treatment rates continuing to be impacted by the pandemic especially in the US. Sales of Blenrep of £118 million grew 33% at AER, 25% at CER, and included the impact of withdrawal from US market in Q4 2022.

Sales of Xevudy were £2,309 million, compared to £958 million sales in 2021. Sales were delivered in all regions, comprising £828 million in the US, £456 million in Europe, and £1,025 million in International.

## Our strategy for growth

Our portfolio of Specialty Medicines is focused on four therapeutic areas: infectious diseases, HIV, immunology/ respiratory and oncology. We're leaders in infectious diseases and HIV innovation and we're also building our positions in immunology and oncology. In the next five years, we expect Specialty Medicines and HIV as a part of Specialty to continue to be an important part of our growth. The increasing convergence of disease prevention and treatment and our expertise in vaccines and medicines mean we are uniquely placed to focus on connections between treatment and prevention.

We do this by accelerating our pipeline as well as prioritising strategic business development which complements are existing portfolio, such as our acquisition of Sierra Oncology and global licence agreement with Mersana Therapeutics.

## Drivers of growth across the portfolio

In HIV, our strategy for growth now and in the future is built on our innovative portfolio of medicines that are transforming the HIV treatment and prevention landscape.

– Launched in 2019, our dolutegravir-based two-drug regimen, Dovato, continues to build positive momentum, benefiting over 143,000 people living with HIV globally and delivering £1,375 million of revenue in 2022.

– Our long-acting therapies are also central to our growth and are delivering results as they launch across our markets.

– In 2021 we launched the only long-acting treatment regimen, Cabenuva (known as Vocabria + Rekambys in Europe and other markets). Non-inferior to daily anti-viral therapy and dosed once every two months, Cabenuva addresses the challenges associated with daily oral therapy of stigma, adherence and daily pill fatigue.

– In January 2022 we launched Apretude in the US. It’s the only long-acting medicine for HIV prevention offering superior efficacy to daily oral prevention (FTC/TDF tablets) and two-monthly dosing. The launch was supported by a direct-to-consumer campaign, as well as innovative community-driven interventions focused on reaching key populations who could benefit most from a preventative option.

– By 2026 we estimate our long-acting regimens Cabenuva and Apretude will generate around £2 billion of sales, representing around a third of HIV net sales.
In immunology/respiratory, we continue to see strong demand from Benlysta and Nucala.

– Benlysta for systemic lupus erythematosus and lupus nephritis in adults and children continues to perform strongly, with around 9,000 US patients initiating therapy in 2022. It also became China’s only biologic medicine of its kind, helping around 12,500 patients in 2022. We’re focused on supporting earlier identification and greater urgency to treat patients before lupus progresses and organ damage occurs (see page 24)

– Nucala, the only targeted biologic therapy approved for use across four eosinophilic diseases, continues to be a driver of growth. We expanded access to Nucala in 2022 with approvals in Europe, Japan and the US for a 40mg syringe for use at home with children. This follows earlier approvals for at-home use for adults. The evidence behind Nucala continues to grow, and in 2022 we shared two-year data from REALITI-A, the real-world study with Nucala in patients with severe eosinophilic asthma, demonstrating how IL-5 inhibition in everyday practice can help to achieve treatment goals. Our pioneering work in IL-5 inhibition continues with the research into depemokimab, a monoclonal antibody specifically engineered with an increased affinity for IL-5 and a longer duration of action to allow longer periods of time between injections (see page 24)

In oncology, Zejula is the only monotherapy PARP inhibitor approved in first-line therapy for newly diagnosed patients with advanced ovarian cancer, regardless of biomarker. This group of patients represents a significant area of growth as healthcare providers are using PARPs more in a first-line setting. Since COVID-19 we have seen the number of patients presenting to their doctors with ovarian cancer symptoms decline and the volume of newly diagnosed ovarian cancer patients is 15-20% below pre-COVID (2019) monthly averages. We expect that numbers will increase again as patients return to normal health practices. We're now working to develop other combination therapies with Zejula (see page 26).

Daprodustat, our treatment for anaemia of chronic kidney disease, is the market-leading and preferred HIF-PHI in Japan, where it’s available as Duvrog. In February 2023 daprodustat was approved as Jesduvrog in the US for adults on dialysis. We are seeking approval in the EU and expect to have a decision mid-2023 (see page 27).

Our COVID-19 treatment Xevudy, developed with Vir Biotechnology, continued to play an important role in pandemic response for vulnerable patients in 2022. To date we have delivered more than two million doses to over 30 countries, generating over £3 billion in sales.



## Performance: Specialty Medicines continued

## Building our commercial capabilities

We are delivering growth across our portfolio by continuing to focus on disciplined commercial and medical execution, capability enhancement, competitive resourcing in customer-facing activity and rigorous investment allocation.

Attaining and keeping leading positions in our markets means attracting and retaining the best people in our industry. We’ve focused on developing our leaders internally and we recruit specific marketing and commercial experts from outside the business.

Over the last year, 67% of senior commercial leadership appointments in Specialty Medicines were internal. We recruited senior people externally to drive growth in oncology and supplement our specialty global marketing capability in our top 10 markets.

We’ve also focused on strengthening sales execution capability in our markets. We appointed 16 general managers in 2022, bringing fresh leadership into 26% of these positions.

## Maintaining strong links with healthcare professionals and patients

Connecting with HCPs and patients helps us to meet their needs. It also helps us to keep them informed about clinical data, products in our pipeline and upcoming launches. The more effectively we interact, the better they understand the science behind our products, their benefits and how best to use them.

We have scaled up our use of data-led omnichannel communication platforms to reach more patients face-to-face and digitally. To date, we've digitally enabled 27 brands and 447 campaigns across 44 markets, doubling our efforts compared to last year, and resulting in incremental growth and market share.
Our use of digital, data and analytics in 2022 extends to driving Medical Affairs effectiveness. Advanced analytics and text mining has produced medical insights which allow for high-quality scientific engagement with experts to improve patient outcomes. We'll continue to prioritise use of omnichannel communication platforms in Medical Affairs to engage HCPs on the latest scientific advances.

## Managing our global supply chain

Our supply chain is a global network that enabled us to produce and deliver 1.8 billion packs in 2022. We've streamlined our network to make it smaller, more agile and more resilient, with the capacity and capability to bring the next generation of medicines to patients all over the globe.

Amid geopolitical uncertainties, we're focused on the availability of energy and commodities, and on managing constraints around freight and other resources needed to supply medicines to patients. Despite these challenges, our programme of productivity and efficiency improvements remains on track. This year we delivered £23 million in savings through the programme, taking the cumulative total to £62 million. Our target for the programme is to deliver £119 million in savings by 2025. These savings support improvements in gross margin.

We have 25 sites manufacturing medicines in our GSK network. Overall, site productivity has increased by 3.9% year on year over the last three years.

## Strengthening our manufacturing base

Modern manufacturing facilities help us launch specialty medicines quickly so we can build and strengthen our market positions and performance.

In June 2022, we opened our new manufacturing facility at Barnard Castle in the UK. It is sustainably designed, paperless and fully automated, using robotic aseptic filling technology to increase efficiency. The facility will manufacture many of the existing and new biopharmaceutical assets in our pipeline.



## Performance: Specialty Medicines continued

We also opened our expanded facility at Upper Merion, Pennsylvania, which is now one of the most advanced single-use facilities for the manufacture of bulk drug substances and able to manufacture a wide range of biopharmaceutical pipeline assets, including monoclonal antibodies. Our expanded facility at Rockville, Maryland, is on target to start manufacturing in 2023. This facility combines single-use systems, large-scale stainless steel manufacturing and automation to produce our lupus treatment, Benlysta. The investment of more than $150 million will increase capacity at Rockville by around 50%.

We’re also investing over £60 million in our new oral solid dose facility at Ware in the UK to help us deliver new products at pace, in partnership with R&D. Product performance qualification (the first set of batches that confirm the commercial manufacturing process performs as expected) is due to start in the second half of 2023.

Streamlining our supply chain helps us control costs and allocate more capital to developing, launching and marketing medicines. This includes investing in AI/ML which helps us to optimise yield, inventory and on-time in-full (OTIF) delivery.

## Maintaining a consistent and reliable supply

A reliable, high-quality supply of products is essential for us to meet patients' needs and maintain our performance. We routinely update our quality management system (QMS) to keep pace with the evolving regulatory environment and new scientific understanding of our products and processes. We've also made our policies and procedures simpler to understand and implement.

We've improved deviation rates, and reliability of supply remains strong with an OTIF measure of 97.2% across our full supply chain and 99.4% for Specialty Medicines.

+ For information on product governance and data on recalls, regulatory inspections and audits, see pages 49 and 50

## Supporting our Innovation ambition

Our Specialty Medicines supply chain continues to support our innovation strategy by delivering launch products across therapy areas and regions worldwide. We are making our internal and external network flexible enough to enable on-time launches of our upcoming medicines. We're also working with R&D by investing in rapid knowledge transfer from chemistry manufacturing & control project teams to manufacturing sites.

Following a successfully managed rapid launch of our COVID-19 therapeutic Xevudy (sotrovimab), by the end of 2022 over two million doses of Xevudy had been supplied globally. We are also preparing for the successful launch and supply of late-stage assets like adprostudat and momelotinib (if approved) in 2023. Our Specialty Medicines supply chain will support multiple late-stage clinical programmes and further upcoming launches in the second half of 2023 and 2024.

+ For details about the General Medicines supply chain, see page 40



## Commercial operations
Performance: General Medicines

From antibiotics to inhaled medicines for asthma and COPD, we have over 150 general medicine products, many of them leaders in their class, making life better for millions of people worldwide.






## Performance: General Medicines

Turnover

£10.1bn

+5% AER, +1% CER



Respiratory £6,548m
Other General Medicines £3,570m

## Key marketed products

<table><tr><td>Product</td><td>Disease</td><td>Total revenue</td><td>Key information</td></tr><tr><td>Trelegy Elipta</td><td>COPD, asthma</td><td>£1,729m +42% AER; +32% CER</td><td>Most prescribed single inhaler triple therapy worldwide, reaching an estimated 5.1 million patients since launch</td></tr><tr><td>Seretide/Advair</td><td>Asthma, COPD</td><td>£1,159m -15% AER; -17% CER</td><td>One of the market-leading ICS/LABA² treatments worldwide</td></tr><tr><td>Relvar/Breo Elipta</td><td>Asthma, COPD</td><td>£1,145m +2% AER; -2% CER</td><td>One of the leading ICS/LABA treatments worldwide powered by its 24-hour, sustained efficacy and the convenience of the Elipta inhaler device</td></tr><tr><td>Ventolin</td><td>Asthma, COPD</td><td>£771m +7% AER; +2% CER</td><td>Global market-leading SABA³ reliever</td></tr><tr><td>Augmentin</td><td>Common bacterial infections</td><td>£576m +35% AER; +38% CER</td><td>Global leader in oral antibiotics available in over 95 countries</td></tr><tr><td>Lamictal</td><td>Epilepsy, bipolar disorder</td><td>£511m +7% AER; +1% CER</td><td>No. 1 brand by sales value in the global lamotrigine market</td></tr><tr><td>Anoro Elipta</td><td>COPD</td><td>£483m -4% AER; -9% CER</td><td>Global market leader in the LAMA/LABA¹ class approved in over 70 countries</td></tr><tr><td>Avodart &amp; Duodart</td><td>Benign prostatic hyperplasia (BPH)</td><td>£330m -1% AER; -3% CER</td><td>Market leaders by sales value in the global dutasteride and dutasteride+tamsulosin FDC⁴ market respectively, approved in over 85 countries</td></tr><tr><td>Avamys/ Veramyst</td><td>Allergic rhinitis</td><td>£321m +8% AER; +6% CER</td><td>Global leader in the inhaled corticosteroids prescription class</td></tr><tr><td>Dermovate, Betnovate, Cutivate, Eumovate</td><td>Inflammatory skin conditions</td><td>£200m 0%AER; +1% CER</td><td>Global leader in topical corticosteroids across 60 markets globally</td></tr></table>

1 LABA/LAMA: long-acting beta agonists/long-acting muscarinic antagonists

2 ICS/LABA: inhaled corticosteroid/long-acting beta agonists

3 SABA: short-acting beta agonist

4 FDC: fixed dose combination

Key information source IQVIA

## Sales performance

General Medicines sales in the year were £10,118 million, up 5% at AER, 1% at CER, with the impact of generic competition in US, Europe and Japan offset by Trelegy growth in respiratory and the post-pandemic rebound of the antibiotic market since H2 2021, in Other General Medicines.

Respiratory sales were £6,548 million, up 8% at AER, 3% at CER. The performance was driven by Trelegy sales of £1,729 million, up 42% AER, 32% CER, including strong growth across all regions. Advair/Seretide sales of £1,159 million decreased 15% at AER, 17% at CER predominantly reflecting the adverse impact of generic competition, with growth in certain International markets due to targeted promotion offsetting the decrease.

Other General Medicines sales were £3,570 million, decreasing 1% at AER, 2% at CER. Augmentin sales were £576 million, up 35% at AER, 38% at CER, reflecting the post-pandemic rebound of the antibiotic market since H2 2021 in the International and Europe regions.
This partially offsets the ongoing adverse impact of generic competition, and approximately two percentage points impact at AER and CER from the divestment of cephalosporin products in Q4 2021.

## Our strategy for impact

The General Medicines portfolio encompasses our primary care medicines from pre-launch R&D assets to growth and established products. In 2022, General Medicines contributed over one third of GSK's sales, helping to fuel growth and investment in R&D.

Our combination of more than 150 products, several of which are market leaders, are expected to impact the lives of millions of patients over the next 10 years. Our products are supplied in more than 112 countries worldwide, delivering over 80% of our total medicines supply volume. Every day, these medicines improve health and make life better for millions of people all over the world.



## Performance: General Medicines continued

With expected growth from Trelegy, Anoro, the established products portfolio in emerging markets and, if successful, gepotidacin and, tebipenem, we are committed to positively impacting more lives every day.

We continue to focus on maximising investment in our growth brands and new opportunities, while managing the expected decline of other products in mature markets as they lose their exclusivity. The decline in established products is well managed, through targeted investments towards growth opportunities and reflects continued strong demand for our core products.

## Drivers of growth across the portfolio

Our main sources of growth in General Medicines in 2022 were Trelegy, Anoro and Augmentin.

Trelegy, our single inhaler triple-therapy for asthma and COPD, has continued to accelerate strongly, with growth in all regions including the US and is the third biggest growth driver (excluding Xevudy) across GSK's portfolio this year. Trelegy, is now prescribed in more than 63 countries, with dual indications in key markets. Several new approvals were received in 2022, further expanding Trelegy's availability to asthma patients in Argentina, Taiwan, New Zealand, Oman, Bahrain, South Korea and Kuwait, and COPD patients in Kuwait and Indonesia.

Trelegy leads market share in our two largest markets, US and Japan, with market shares significantly exceeding the next largest competitor. In 2022 the competitive market position for Trelegy was further strengthened by a network meta-analysis of the triple therapy class demonstrating differentiation among the COPD single-inhaler triple therapies. We continue to expect Trelegy to be a key driver of growth in General Medicines in the coming years.

Anoro is approved in approximately 70 countries for the treatment of symptomatic COPD. Anoro remains the global market leader in the LAMA/LABA class, with continued growth in global sales (ex-US). Anoro has a robust clinical data profile which includes head-to-head data within the LAMA/LABA class and versus other common initial maintenance therapy options, such as LAMA.

Augmentin is a global leader in oral antibiotics and available in 95 countries. It has reached over 2.5 billion patients since launching 41 years ago, and continues to grow strongly in emerging markets. Augmentin grew 35% AER, 38% CER to £576 million with recovery in key emerging markets and Europe, recovering stronger than any competitor post-pandemic. Today, Augmentin is still being recognised for its impact and recently won the bronze in the best pharmaceutical product category for the Prix Galien Golden Jubilee awards in October 2022.

Two important products in our late-stage pipeline, anticipated to be future growth drivers for General Medicines, include gepotidacin, for uUTIs and urogenital gonorrhoea, and tebipenem HBr, a late-stage antibiotic licensed exclusively from Spero Therapeutics, that may treat cUTIs (see pages 20 and 22).

## Maximising commercial capabilities

We have a targeted investment strategy to deliver returns, backing our largest opportunities, both branded and geographic, to maximise launches in new medicines and indications. In parallel, we target our investments appropriately to optimise returns in mature brands where there is a broader range of opportunity and risk.

We continue to invest in omnichannel and digital customer engagement. Digital plays an important role in how we connect with our customers, and this is especially important in General Medicines given our expansive global footprint. Our data-driven customer experience (DDCX) programme for Trelegy was recognised externally by the International Customer Experience Awards (iCXA) across all sectors. In 2021, among 120 companies and 353 initiatives entered, we won three silver awards for Trelegy competing across all industries, in the following categories:

– Best Business-to-Business Customer Experience Strategy

– Business Change and Transformation

– Customer Experience Team of the Year

## Maintaining an efficient supply chain

Demand for many products in our General Medicines portfolio increased significantly as COVID-19 lockdowns lifted and global markets recovered from the effects of the pandemic. We increased packs supplied from 1.60 billion in 2021 to 1.64 billion in 2022. This growth demonstrated the resilience of our General Medicines brands. We anticipate this further increasing to 1.67 billion in 2023.

To keep our supply chain lean, we continue to simplify our portfolio by standardising packaging and formats and discontinuing products. By the end of 2022, General Medicines had reduced the number of brands in the portfolio by a further 9% from 194 to 177, and we plan to further discontinue non-priority brands in 2023.

We have also taken key decisions as part of our focus on productivity and efficiency, for example to outsource the manufacture of amoxicillin.

We rigorously benchmark the performance of our General Medicines supply chain against the competition and make thoughtful choices on how we optimise both our cost and cash footprint for the portfolio.

+ For more about our global supply chain, which also covers Specialty Medicines, see pages 36 and 37



# Responsible business

Our approach to ESG is an integral part of our strategy and investment case. It helps us build trust and create value for our shareholders and society – so we can get ahead of disease together.






## Responsible business

Being a responsible business means getting ahead of disease together in the right way. We therefore need to consider ESG impacts across everything we do, from the lab to the patient. That's why ESG is embedded in our strategy and supports our sustainable performance and long-term growth. It helps us build trust with and deliver returns to our stakeholders, reduce risk to our operations and deliver positive social impact.

## Our six ESG focus areas

We can only deliver on our purpose if we embed ESG into everything that we do. We have identified six ESG focus areas that address what is most material to our business and the issues that matter to our stakeholders. These focus areas are core to our strategy and are the areas where we can have the greatest positive impact on some of society’s most urgent challenges. These focus areas are:

– Access to healthcare

– Global health and health security

– Environment

– Diversity, equity and inclusion

– Ethical standards

– Product governance

Our approach is guided by extensive stakeholder engagement and the key issues relevant to our industry and company. The results of our most recent materiality assessment reaffirmed that the most material issues for our business were well aligned with our six ESG focus areas. We are aware, however, that being a responsible business is not a static requirement and our operating environment continues to change at pace. We will continue to adapt, respond and proactively change our approach, to ensure GSK continues to deliver strong ESG performance.

## Our ESG Performance Rating

To support the integration of ESG into strategy delivery and to make our ESG performance measurable and verifiable, we have introduced a new ESG Performance Rating. The rating is one of our corporate KPIs and measures progress against key metrics aligned to each of our six focus areas. In 2022, this included 23 metrics, and we cover our performance against these in this section of the report.

## External benchmarking

Detailed below is how we perform in key ESG ratings that we are frequently asked about by investors:

– Access to Medicines: Ranked 1st in the Access to Medicines Index in 2022 and an industry leader in the 2021 Antimicrobial Resistance Benchmark

– S&P Corporate Sustainability Assessment: Ranked 2nd in the pharmaceuticals industry with a score of 86 (as at 17 February 2023) and included in the DJSI World and Europe indices
The metrics were developed with stakeholder input, and our understanding of the key issues for our industry and our company. We are committed to ensuring that our ESG Performance Rating responds to stakeholder expectations, so we will continue to review the metrics as our business and external expectations change.

To create the ESG Performance Rating, management sought metrics that:

– Are well defined to ensure we have a standardised approach

– Can be used consistently in future years

– Are ambitious and achievable

– Can be externally assured

– Are meaningful for stakeholders

## How we assess performance

GLT is accountable for delivering progress against the metrics and regularly reviews performance along with the Board’s Corporate Responsibility Committee (CRC). Each individual metric is assessed as either: on track (metric met or exceeded); on track with work to do (at least 80% of metric has been achieved); or off track (metric missed by more than 20%).

In addition, in order to calculate the overall ESG Performance Rating, performance across all metrics is aggregated to a single score to illustrate whether we are on track, on track with work to do, or off track. This rating is defined below:

On track: 70% of all metrics are on track

On track with work to do: more than 50% of all metrics are either on track, or on track with work to do

Off track: more than 50% of all metrics are off track

## 2022 ESG Performance Rating

Our 2022 ESG Performance Rating is on track, based on 83% of all performance metrics being met or exceeded.

Assessment of performance against our annual targets has been reviewed, and the overall ESG Performance Rating score has been externally assured for 2022.

– FTSE4Good: Member of FTSE4Good Index since 2004

– CDP: A- in Climate change, B in Water security, A- in Forests (palm oil) and B in Forests (timber)

– Sustainalytics: Low risk rating

– MSCI: AA rating

– Moody's ESG solutions: Ranked 2nd in the pharmaceuticals sector

– ISS Corporate Rating: B+ rating



## Access

Our ambition is to positively impact the health of 2.5 billion people by the end of 2030. We will achieve this by developing vaccines and medicines and making them available through responsible pricing, strategic access programmes and partnerships.

## Our commitment

Make our products available at value-based prices that are sustainable for our business and implement access strategies that increase the use of our medicines and vaccines to treat and protect underserved people.

## How we assess performance

– Develop and externally publish pricing and access principles

– Progress towards our 2030 goal of reaching 1.3 billion people in lower income countries with our products

## Progress in 2022

## Putting the right value on innovation

We follow a set of pricing and access principles, published for the first time in 2022. These help us to get the balance right between responsible pricing and a sustainable, profitable business that allows us to re-invest financial returns in future innovation, while ensuring people can access medicines and vaccines.

In 2022, in the US, through GSK and ViiV Healthcare’s Patient Assistance Programs Foundation, we provided prescribed medicines and vaccines to more than 78,000 low-income uninsured, underinsured and Medicare Part D patients.

In the US, during the year, our combined average net price (after discounts, rebates or other allowances) for our pharmaceutical and vaccines portfolio increased by 1.4%, while the average list price increased by 3.8% compared to 4.9% (list) for the industry, which demonstrates we are responsible in our pricing decisions \( ^{1} \) . Over the past five years, the average net price for our products decreased by 1.1% annually, while the average list price rose by 3.9% compared to 5.0% (list) for the industry \( ^{1} \) .

## Reaching patients in lower income countries

Our goal is to reach 1.3 billion people in lower income countries with our products by the end of 2030, through access initiatives such as voluntary licensing, donations and our work with Gavi, the Vaccine Alliance. In 2022, we reached 73 million people with our products and supplied an additional 533 million doses of albendazole \( ^{2} \) . In 2022, we ranked first in the Access to Medicines Index for the eighth consecutive time.

## Vaccines

We have been a partner with Gavi since its foundation in 2000. We reserve our lowest vaccine prices for Gavi and similar organisations and, in 2022, we passed the milestone of supplying Gavi with more than one billion vaccines since 2010.

Our partnership includes supplying Cervarix, a critical vaccine in lower income countries for addressing cervical cancer. In 2022, we supplied around 40 million doses of our pneumococcal vaccine, Synflorix, to eight Gavi-eligible countries at our lowest price. Our Rotarix vaccine against rotavirus reaches children across 27 Gavi-eligible countries and four former Gavi countries. Since March 2021, as well as Synflorix, we have also offered Rotarix through the Humanitarian Mechanism, to civil society organisations serving refugees and working in other emergency situations. We are also a long-standing supplier of oral polio vaccines (OPV) through UNICEF and, in 2022 alone, supplied around 95 million doses to help eradicate polio.

## Neglected tropical diseases

In 2022, we donated 533 million doses of albendazole, a medicine used to help eliminate lymphatic filariasis and treat soil-transmitted helminths. We have also extended our soil-transmitted helminths commitment to include preschool children and made an additional commitment to donate albendazole for treatment of echinococcosis.

## HIV

In 2022, ViiV Healthcare and the Medicines Patent Pool (MPP) signed a new voluntary licensing agreement to allow generic manufacturers to develop, manufacture and supply cabotegravir long-acting for HIV pre-exposure prophylaxis.

ViiV Healthcare also has voluntary licensing agreements with 17 generic manufacturers to produce and sell low-cost single or fixed-dose combination products containing our HIV medicine dolutegravir for adults in 95 low- and middle-income countries, with one direct licence and the others via the MPP. There are similar agreements with 14 generic manufacturers for children, covering 123 countries. As a result of these voluntary licence agreements, around 21 million people living with HIV across 122 countries had access to a generic product containing dolutegravir by the end of 2022. This is at least 80% of people living with HIV on antiretrovirals in low- and middle-income countries.

In 2022, ViiV Healthcare donated around 7,200 packs of antiretroviral medicines to NGO partners and national HIV and AIDS programmes to support people living with HIV who have been impacted by the conflict in Ukraine. ViiV has also provided over  \( £800,000 \)  through its Positive Action programme to support 11 community-based organisations with humanitarian response activities, both within Ukraine and in surrounding countries hosting refugees.



## Responsible business continued

Positive Action, ViiV Healthcare’s community grant-giving programme, celebrated its 30th anniversary in 2022 with a year-long campaign to showcase the people at the heart of the programme, the partners in implementation and the progress made through collaboration. It invested more than £12.6 million in 2022, reaching approximately 392,000 people and providing 137 grants across 33 countries.

## Malaria

Working with our partners, more than 1.2 million children in Africa have now received at least one dose of our malaria vaccine, Mosquirix (RTS,S/AS01 E). In September 2022, the WHO awarded pre-qualification to the vaccine. This is a prerequisite for UN agencies to procure the vaccine, and an important step in rolling it out in countries with moderate to high P. falciparum malaria transmission.

GSK, PATH and Bharat Biotech have agreed a product transfer to help ensure long-term supply of the RTS,S malaria vaccine. We have committed to supply up to 18 million doses over the next three years, in addition to our donation of up to 10 million doses to the WHO-coordinated Malaria Vaccine Implementation Programme in Ghana, Kenya and Malawi.

+ For full details of our progress against our six focus areas, please see our ESG Performance Report

## Global health and health security

We use our expertise to address the biggest health challenges for underserved people around the world.

## Our commitment

To develop novel products and technologies to treat and prevent priority diseases, including pandemic threats.

## How we assess performance

– Progress three Global Health pipeline assets to address priority WHO diseases

## Progress in 2022

## Global health R&D

In June 2022, GSK, including ViiV Healthcare, announced a £1 billion investment in R&D to help us get ahead of infectious diseases in lower income countries. The 10-year investment will support R&D on new medicines and vaccines to prevent and treat tuberculosis (TB), malaria, HIV, enteric diseases, and neglected tropical diseases, and to reduce AMR. In 2022, we progressed 12 Global Health pipeline assets to address priority WHO diseases, including malaria and TB, exceeding our target of three.

We want to discover shorter, simpler and safer treatments for TB. In 2022, alongside our partners and through public-private research consortiums, we continued to progress our pipeline of novel TB medicines. In 2022, we announced positive phase IIa study results for GSK3036656, a new first-in-class candidate medicine for patients with TB. Results of the study demonstrated the potential for the candidate to become a component of simpler treatment regimens in the future.

In partnership with BioVersys, the University of Lille and the Innovative Medicines Initiative (IMI) project, TRIC-TB, we also successfully completed phase I trials of BVL-GSK098, which has the potential to help tackle drug resistance by boosting the activity of an existing antibiotic.

With our partners, we’ve brought two products for the prevention and treatment of malaria to market – the world’s first vaccine against malaria, and a single-dose, radical cure for P. vivax malaria.
In March 2022, the Australian regulator, the Therapeutic Goods Administration, approved the use of single-dose medicine tafenoquine in children aged two and above in combination with chloroquine for the radical cure of P. vivax malaria.

The FDA approved Triumeg PD, the first dispersible single tablet formulation containing dolutegravir for children weighing more than 10kg, which increases the age-appropriate treatment options for children living with HIV. At the end of 2022, the CHMP of the EMA also issued a positive opinion recommending marketing authorisation for Triumeg PD for children 14kg and above.

Invasive non-typhoidal salmonella disease can be life-threatening for children in Africa and is a key driver of AMR. We’re using our innovative vaccine technology in partnership with the University of Oxford and Vacc-iNTS, to develop a potential candidate vaccine using our Generalised Modules for Membrane Antigens technology.

To help support global R&D, in December 2022, we announced the fourth call for proposals as part of the Africa Open Lab. The call for proposals is aimed at African early-career scientists who are based in sub-Saharan Africa, with a focus on infectious diseases which disproportionately affect sub-Saharan populations, such as malaria, TB and neglected tropical diseases.

## Getting ahead of antimicrobial resistance

We have more than 30 R&D projects across medicines and vaccines that are relevant to AMR, ranging from early-to late-stage development. These include gepotidacin, which could be the first novel oral antibiotic treatment for uncomplicated urinary tract infections in over 20 years; and in 2022, we announced an exclusive licence agreement with Spero Therapeutics for tebipenem HBr, a late-stage antibiotic that may treat complicated urinary tract infections. 13 of these projects target pathogens deemed 'critical' or 'urgent' by the WHO and the US CDC. See page 22 for more about our R&D pipeline.



## Responsible business continued

Surveillance is central to tackling AMR. In 2022, we shared data from our long-running Survey of Antibiotic Resistance (SOAR) study, which tracks community-acquired respiratory infections, with the new AMR Register, developed by Vivli. In 2022, we also worked with the AMR Industry Alliance to publish a new Antibiotic Manufacturing Standard. This provides clear guidance to manufacturers in the global antibiotic supply chain to help ensure that their antibiotics are made responsibly and in compliance with scientifically robust discharge limits.

+ For full details of our progress against our six focus areas, please see our ESG Performance Report

## Future pandemic preparedness

In July 2022, GSK, along with other major biopharmaceutical companies, signed up to the Berlin Declaration. This sets out the industry’s vision for equitable access during future pandemics.
The declaration stated the sector’s willingness to reserve an allocation of real-time production of medicines and vaccines for distribution to priority populations, as determined by health authorities, during future pandemics.

In 2022, GSK concluded a series of contracts under which we would provide at least 200 million doses of pandemic influenza vaccine to governments around the world.

In February 2022, we extended our pandemic influenza vaccine stockpile contract with the United States government. This was followed by a renewed agreement, in June 2022, for supply of pandemic influenza vaccines to the WHO, and in July 2022, a contract with the government of Canada for both seasonal and pandemic influenza vaccines. We signed an agreement with Europe for the reservation and future production and supply of pandemic influenza vaccines. We are also continuing to partner with the BARDA to manufacture and assess the safety and immunogenicity of pandemic influenza vaccine candidates.

## Environment

We continue to work hard to do more to protect the environment, often in partnership with others. We’ve set clear and measurable targets to help achieve our goals.

## Our commitment

Commit to a net zero, nature positive, healthier planet, with ambitious goals set for 2030 and 2045.

## How we assess performance

The following metrics are included in our ESG Performance Rating and support delivery of our carbon and nature ambitions:

## – Climate

– Operational emissions reduction (scope 1 and 2 market-based emissions)

– Industrialisation of green Ventolin initiated, and clinical and non-clinical data available to support regulatory submissions

– Percentage of carbon offset volume in project pipeline
– Water

– Average of the percentage of GSK sites and suppliers compliant with wastewater active pharmaceutical ingredient limits and the percentage of suppliers that are compliant with the AMR Industry Alliance Common Antibiotic Manufacturing Framework and discharge limits

## – Waste and materials

– Operational waste and material reduction at our sites

– Biodiversity

– Number of high-risk materials implementing sustainable sourcing roadmaps

## Progress in 2022

## Climate

We have set a clear pathway to a net zero impact on climate with ambitious goals for 2030 and 2045. We have updated our climate targets to be in line with the new Science Based Targets initiative (SBTi) Net-Zero Standard. By 2030, we aim to reduce carbon emissions across all scopes by 80%, against a 2020 baseline, with the remaining 20% offset through investment in high-quality nature-based solutions. We have also now set a longer-term target to reduce carbon emissions by at least 90% with the remainder tackled through high-quality offsets by 2045. For additional context on these changes see pages 16 and 17 of the ESG Performance Report.

## Targets¹:

– 80% reduction in carbon emissions and investment in nature-based solutions for the remaining 20% of our footprint by 2030 (all scopes) \( ^{2} \) 

– 100% renewable electricity by 2025 (scope 2)

– Net zero emissions across our full value chain by 2045 (all scopes) \( ^{3} \)



## Responsible business continued

## Performance

In 2022, we reduced our scope 1 and 2 carbon emissions by 6% compared with 2021. This was primarily through increasing our use of renewable electricity and continued delivery of energy efficiency across our sites, such as the installation of new solar panels, upgraded lighting and replacing chillers to reduce the use of ozone depleting refrigerant. As a member of RE100, we have committed to source 100% renewable electricity by 2025. In 2022, we reached 73%, an increase of 6% since 2021 and 28% since 2020.

Following the demerger of our Consumer Healthcare business, we are restating our value chain carbon footprint for our baseline year 2020. In 2021 (our latest available data), our scope 3 emissions reduced by 13% compared with 2020. These reductions reflect the evolution of our product portfolio.

Approximately 29% of our total emissions footprint comes from the goods and services that we buy. In September 2022, we launched a Sustainable Procurement Programme, which will require our suppliers to, among other things, disclose emissions, set carbon reduction targets aligned with  $ 1.5^{\circ} \) C, and switch to renewable power and heat.

We are also working with our peers through the Energize programme to encourage the use of renewable energy throughout the pharmaceutical sector’s supply chain. In 2022, nine suppliers formed the first Energize buyer’s cohort, who together will purchase two terawatt-hours of renewable electricity.

See pages 55 to 62 for our disclosure on climate risk and resilience in line with the Task Force on Climate-related Financial Disclosures (TCFD) framework.

## Nature

We are committed to working towards our goal of having a net positive impact on nature by 2030, by reducing our environmental impacts across water, waste and materials, and biodiversity and by investing in protecting and restoring nature.

## Targets¹:

– Achieve good water stewardship at 100% of our sites by 2025 \( ^{2} \) 

– Reduce overall water use in our operations by 20% by 2030

– Be water neutral in our own operations and at key suppliers in water-stressed regions by 2030 \( ^{2} \) 

– Zero impact active pharmaceutical ingredient (API) levels for all sites and key suppliers by 2030 \( ^{3} \) 

– Zero operational waste, including eliminating single-use plastics, by 2030 \( ^{4} $ 

1 Targets are measured against a 2020 baseline
2 See our Environment Basis of reporting for definition
3 Zero impact against predicted no effect concentrations
4 Where regulatory obligations allow, and excluding plastics which are critical to product discovery and development and health & safety
– 25% environmental impact reduction for our products and packaging by 2030

– 10% waste reduction from our supply chain by 2030

– Positive impact on biodiversity at all sites by 2030

– 100% agricultural, forestry and marine-derived materials sustainably sourced and deforestation free by 2030

## Performance

In 2022, we reduced overall water use in our operations by 5% since 2021 and by 1% in sites in high water stress regions. This is a decrease of 23% for overall water use and 6% for sites in high water stress regions against our 2020 baseline. This achieved our 2030 overall water use reduction target, which we will now review. 100% of our sites are now good water stewards, in line with the Alliance for Water Stewardship’s definition.

We have initially identified three water basins in water-stressed areas in Algeria, India and Pakistan where we have manufacturing sites, and where we aim to be water neutral. At our manufacturing facility in Nashik, India, we have built plants for rainwater harvesting.

In 2022, 100% of our sites and 98% of our suppliers that manufacture antibiotics complied with AMR Alliance industry standards on safe discharges.

In 2022, we continued to reduce the waste from our sites and increase the amount of materials recovered through circular routes like reuse or recycling. We are also targeting materials across our existing product portfolio.

We are progressing our plans for net positive biodiversity at our own sites by investing in individual site action plans that improve habitats, protect species and improve soil and water quality. In 2022, we completed baseline biodiversity assessments for 80% of our sites. We have commenced biodiversity uplift projects at our three largest R&D facilities. We have also completed a full assessment of our biodiversity impact (across the entire value chain) and will be taking targeted actions to address the highly-stressed areas.

In the lead-up to the UN Convention on Biological Diversity, the critical COP15 conference in Canada at the end of 2022, we worked with partners to call for mandatory disclosure by businesses and financial institutions of their impacts and dependencies on nature.

We are part of the LEAF Coalition (Lowering Emissions by Accelerating Forest finance), a private-public effort to protect tropical forests. We are also testing a framework for voluntary carbon credits from the Voluntary Carbon Market Integrity Initiative, which is working to establish a globally-standardised benchmark to guide the use of carbon credits by companies.

See pages 62 to 63 for how we plan to disclose on our impacts and dependencies on nature in line with the emerging Taskforce on Nature-related Financial Disclosures (TNFD) framework.

+ For full details of our progress against our six focus areas, please see our ESG Performance Report



## Diversity, equity and inclusion

Diversity, equity and inclusion (DEI) are central to our purpose of getting ahead of disease together. Being an inclusive and diverse business – and doing business inclusively – makes us more successful, making the most of our people’s potential and increasing our positive impact.

## Our commitment

Create a diverse, equitable and inclusive workplace; enhance recruitment of diverse patient populations in our clinical trials; and support diverse communities.

## How we assess performance

– 75% of phase III trials initiated in 2022 will have proactive plans in place designed to enrol appropriately diverse trial participants, consistent with disease epidemiology

– Performance towards 2025 aspirations through fair and equitable opportunities:

– have women hold at least 45% of VP-and-above roles globally by the end of 2025

– have at least 30% ethnically diverse leaders in our roles at VP and above in the US, and increase the percentage of Black or African American, and Hispanic or Latinx VP-and-above leaders year on year

– have at least 18% ethnically diverse leaders in our roles at VP and above in the UK, and increase the percentage of Black VP-and-above leaders year on year

– Improve year-on-year spend with certified US-based diverse-owned suppliers

## Progress in 2022

## Building an inclusive business

We are committed to improving diversity in clinical trial enrolment and are already using our disease insights to set diversity enrolment goals. At the end of 2022, 100% of GSK’s phase III trials had a diversity plan in place to enrol the groups most affected by the disease being studied, based on epidemiology data. For example, in our hepatitis B trials, a disease that disproportionately affects people of African and Asian descent, 52% of participants are of Asian origin, and we are actively working to improve the representation of participants of African descent.

Our supplier diversity programme is well established in the US, and an expansion plan is being developed for the UK. We have a target to increase spend annually with certified US-based diverse-owned suppliers. This was significantly exceeded in 2022 through a combination of spend increases with selected suppliers in marketing, sales and technology, as well as identification of new global diverse suppliers and a strong multi-year strategy of engagement with key advocacy groups.
Our GSK Science in the Summer initiative offers free, hands-on STEM learning to students in traditionally under-represented groups in STEM careers or from under-resourced communities in the US. In 2022, it reached more than 30,000 students nationwide.

## Nurturing all our people

In 2022, 42% of women held VP-and-above roles globally, compared with 40% in 2021. Women made up 47% of all employees in 2022, and 50% of all management roles.

We published our sixth UK gender pay gap report in 2022. Our gender pay gap for all permanent UK-based GSK employees is -1.36% (mean), compared to the national average of 13.9%. We published our first UK ethnicity pay gap report for 2022 using the same approach as our gender pay gap. Our ethnicity pay gap for all permanent UK-based GSK employees is 0.06% (mean), at this time there is no national average comparator.

In those countries that meet our criteria for data confidentiality and anonymity, we disclose the race and ethnicity of our people at each level and set aspirational targets. Currently, the US and the UK meet those criteria. In the US in 2022, we have 31.3% of ethnically diverse leaders at VP level and above, reaching our 2025 aspirational target of at least 30%, and increasing the percentage of Black or African American and Hispanic or Latinx people in those roles year on year. In the UK in 2022, we have 14.3% of ethnically diverse leaders at VP and above, continuing to make progress towards our 2025 aspirational target of reaching at least 18%. Black representation at VP and above remains flat and we will be focused in our efforts to achieve our aspiration for year-on-year growth.

We are members of the UK government’s Disability Confident scheme and are an active member of the Valuable 500 pledge, a grouping of 500 global companies committed to placing disability inclusion on the leadership agenda. We are delivering on the scheme’s objectives through our long-term, measurable, disability confidence plan, which includes educating our people on the issue.

In 2022, we introduced a new global minimum standard of 18 weeks' parental leave for primary and secondary carers for all forms of family, a new global minimum standard for care of a family member for end of life or serious health emergencies, insured benefits to include same sex partners wherever possible, a new financial wellbeing service and mental health training – available to everyone.

This year, we were recognised as a Gold employer within Stonewall's Top Global Employers Index. Our Allyship programme received an award recognising the tangible impact the campaign has had on the lives of LGBT+ employees. We also achieved the Human Rights Campaign Foundation's Best Places to Work for LGBT+ Equality standard in 2022.

+ For full details of our progress against our six focus areas, please see our ESG Performance Report



## Ethical standards

Our culture guides our people to do the right thing and Speak Up about any concerns they have. It is important that all our people live up to this, and we expect the same of our suppliers.

## Our commitment

Promote ethical behaviour across our business by supporting our employees to do the right thing and working with suppliers that share our standards and operate in a responsible way.

## How we assess performance

– 100% of employees and complementary workers complete GSK’s 2022 mandatory training

– Percentage of employees who believe they ‘can and do Speak Up if things don’t feel right’ is above the general industry benchmark \( ^{1} \) 

– Number of employees leaving GSK’s employment for misconduct in the last 12 months versus the three-year rolling average

– 80% of direct high-risk suppliers achieve GSK’s minimum EcoVadis score or have an improvement plan in place

## Progress in 2022

## Supporting GSK people to do the right thing

In 2022, we launched our new Code of Conduct which reflects our purpose to unite science, technology and talent to get ahead of disease together. Our new Code sets out the commitments we make as a company and to each other to deliver on our purpose and ambitions. In 2022, 100% of employees and 98% of complementary workers completed the accompanying global mandatory learning curriculum where due by year end.

Those in certain high-risk roles or geographic regions also complete additional anti-bribery and corruption (ABAC) training. In 2022, 100% of employees and 96% of complementary workers completed this training where due by year end. Our approach to managing ABAC risk, and other risks relating to ethical standards, forms part of our well embedded risk management framework, which is described in detail on pages 51 to 52.

## Reporting and investigating concerns

This year, we have updated how we report the breakdown of types of policy violations to provide more granularity by case class. In 2022, we saw an overall decrease in disciplinary cases, attributed to, in part, a revision to our procedures for discipline regarding late completion of mandatory training, now reported under the employee conduct category.
Upholding our commitment to human rights
We are signatories to the UN Global Compact and our Human Rights Position statement lays out our commitment to the UN Guiding Principles on Business and Human Rights. During the year, we established a Human Rights Steering Group, which has a formal reporting mechanism to the Board’s Corporate Responsibility Committee.

In 2022, we developed guidance to enhance supplier visits to help employees better understand labour and human rights non-compliances. To support this guidance, we also developed and delivered labour rights training to environment, health and safety (EHS) and procurement employees to better equip them to spot human rights issues when visiting suppliers.

We are committed to the application of fair and equitable pay practices, which includes ensuring that all employees globally receive pay that is competitive in their local markets and sufficient to support a sustainable standard of living. In 2022, we completed the first global living wage review in partnership with the Fair Wage Foundation. We assessed the pay of all our employees (over 75,000 people in 87 countries) and differences were detected in fewer than 200 cases, in 11 countries. All necessary adjustments will be made by the end of the first quarter of 2023. We will be factoring the living wage data into our standard compensation processes to ensure that we continue to offer a fair wage, and have built an annual living wage review into our standard cycle.

## Working with third parties

We expect our third parties to meet our ABAC and labour rights standards and to comply with our standards on quality, health and safety, and the environment. See pages 285 to 295 for further information.

We updated our Third-Party Risk Management (TPRM) programme, which evaluates and mitigates risks introduced by third parties engaged by GSK to provide goods or services.

In 2022, for our high-risk third parties – determined by location in high-risk markets and size of spend – we performed 7,168 assessments across 20 risk areas. Over 62% of these assessments presented risks in one or more areas. Most of these third parties are goods and services providers (77%), distributors and wholesalers (5%), contract manufacturers and suppliers (1%) and direct material suppliers (1%). We also use tools to assess how suppliers manage risks, including EcoVadis desktop assessments.



## Responsible business continued

We visit sites, in person or virtually, to help suppliers better understand and control their risks. The relaxation of travel restrictions has allowed us to increase in-person visits to identify and reduce risk, enabling us to conduct 50 physical visits across 63 priority suppliers this year \( ^{1} \) . We completed warehouse safety surveys for 54 priority suppliers, 38 contract manufacturing suppliers and 15 large warehouses that hold stock this year. These surveys have generated corrective and preventative action plans, all of which we expect to complete in 2023.

In 2022, we conducted 47 supplier audits, compared with 49 in 2021, following industry standard Pharmaceutical Supply Chain Initiative guidelines, with any corrective and preventative actions tracked to completion. We have also trained more than 600 supplier employees on EHS and ESG fundamentals in 2022, revised EHS contractual obligations, tracked management actions to completion and have helped suppliers improve their EcoVadis scores \( ^{2} \) . See page 293 for further information.

## Data and engagement

We have created a new digital, privacy and information security team within Legal and Compliance, to streamline support and provide expertise around GSK’s digital and data strategy.
Privacy and the ethical use of data are part of the global mandatory learning curriculum Living our Code that all our people have to complete. We ensure that key privacy personnel have certifications and sufficient training and experience to carry out their roles effectively.

We are investing in our AI/ML capability to, for example, help analyse patients' genetic data. We are mindful that AI and machine learning can raise ethical issues and are subject to evolving decisions from policymakers on how best to promote trust in these systems and avoid unintended outcomes or harmful impacts.

In R&D, we have oversight boards and a new advisory panel that oversees controls to manage how we use or re-use data and respond to bioethical questions in our research activities.

## Political engagement

As a major multinational company, we seek to contribute to public policy debate, especially in relation to life sciences and healthcare. In all of our political engagements, we are committed to ensuring that we adhere to the highest ethical standards and legislative requirements. We do not make corporate political contributions, nor do we sponsor party political meetings anywhere around the world.

+ For full details of our progress against our six focus areas, please see our ESG Performance Report

## Product governance

Ensuring the quality, safety and reliable supply of our products is critical to protecting patients and delivering health impact.

## Our commitment

We commit to maintaining robust quality and safety processes, and using data and new technologies responsibly.

## How we assess performance

– Average number of critical and major findings by FDA/MHRA/EMA regulators \( ^{3} \) 

– Percentage of inspections from all regulators with no critical findings or official action indicated

– Number of FDA warning letters

– Total number of Class I/II external product recalls across all markets

– Register and disclose all human subject research of GSK products. Specifically, register protocol summaries for studies initiated in 2022; and disclose results summaries for studies with results due in 2022

## Progress in 2022

## A focus on quality management

Our GSK Quality Management System is a detailed and specific framework which describes how we comply with regulatory requirements and other standards across our markets. It addresses global and local regulations across manufacturing and distribution processes, and is based on principles defined by the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use.



## Responsible business continued

## Inspections, recalls and audit

In 2022, we had 122 regulatory inspections at our manufacturing sites and local operating companies, compared with 111 in 2021. We remain prepared for inspections from regulators and received no warning letters from the US FDA or critical findings from the Medicines and Healthcare products Regulatory Agency (MHRA) and EMA regulators in 2022; however we received one critical finding from the Chinese regulator \( ^{1} \) . We continue to learn from and respond to all inspection findings, taking the necessary action to address them.

Throughout 2022, we had no Class I product recalls. There were fewer Class II and III recalls than in 2021 \( ^{2} \) . We will not hesitate to voluntarily recall products to protect patients.

## Working with our suppliers on quality

We expect all our contract manufacturers and suppliers to comply with GSK standards, and regularly conduct audits to verify that they do. In 2022, we conducted 1,060 quality audits of suppliers, with an increased focus on API suppliers.

We have a comprehensive quality oversight model that is aligned to our Quality Management System and uses a risk-based approach to assess, qualify, manage and monitor our third-party suppliers, driving continuous performance.

## Maintaining pharmacovigilance

Pharmacovigilance aims to protect those who use medicines and vaccines and support public health programmes with reliable, comprehensive information on the overall benefit-risk balance of our products. We have a well established and rigorous worldwide system to monitor and review the safety of our products throughout clinical development and after regulatory approval.

## Vigilance against falsified medicines and vaccines

We have a robust approach to handling all falsified product incidents, ensuring that cases of confirmed counterfeit products are reported to the WHO and to relevant regulatory authorities. We actively participate in legal proceedings against illegal actors, provide regular training to customs and local authorities and we monitor online marketplaces and social media to request takedowns of sites illicitly selling prescription-only medicines.

## Committed to transparency

As part of our commitment we have made 7,377 protocol summaries and 6,295 summaries of results available since the set-up of the GSK trial register in 2004. We have also listed 2,559 studies for data sharing via www.vivli.org and www.clinicalstudydatabasequest.com.

+ For full details of our progress against our six focus areas, please see our ESG Performance Report



## Risk management

Our Board continuously reviews and oversees our risk management and internal control framework, which reflects who we are as a responsible biopharma company with bold ambitions for patients.

## Managing our risks in line with our long-term priorities

Our well embedded risk management and internal control framework gives our Board the ability to evaluate and oversee how the company manages principal and emerging risks in line with our strategy and long-term priorities as a fully-focused biopharma company, following this year’s demerger of Haleon. Our company-wide policy sets out the requirements, roles and responsibilities for the management and governance of risks and controls, as well as supporting guidance on the essential elements of our internal control framework. We routinely evaluate our framework for improvements.

## Board oversight of risk appetite and management systems

The Board oversees our risk management system and establishes our risk appetite, supported by the Audit & Risk Committee (ARC). The Corporate Responsibility Committee (CRC) and Science Committee further assess the effectiveness of risk management strategies that fall within their defined remits. Our Risk Oversight & Compliance Council (ROCC) helps the ARC, CRC and Science Committee to oversee the risks, and the strategies used to address them. Alongside this, risk management and compliance boards across the Group promote the ‘tone from the top’, establish our risk culture and oversee the effectiveness of risk management activities, while also communicating information about internal controls. Management is held accountable for delivering on its objectives in line with the established risk appetite pertaining to principal risks. An enterprise risk owner is responsible for each principal risk, overseen by a GLT member. Risk owners report risk and mitigation to ROCC and the appropriate Board committee each quarter. Legal and Compliance support these efforts by advising on our business strategies, activities, risks and controls, and Audit & Assurance provides assessments of the adequacy and effectiveness of our framework.

## Assessing emerging and current risks

Our risk assessment process considers the likelihood and impact of risks, and the timescale over which a risk could occur. As well as considering current risks, we evaluate emerging risks that could affect our ability to achieve our long-term priorities – that is, risks on the three-year horizon, in line with our viability statement. We also define risks as ‘emerging’ if we need to know more about how likely they are to materialise, or what impact they would have if they did. We’ll evaluate whether to investigate further before classifying them as principal risks.

Our risk management and compliance boards at all levels of the organisation identify emerging risks on an ongoing basis, and ROCC discusses emerging risks at each meeting. At the same time, we scan the risk horizon throughout the year to identify external trends that may be opportunities and/or emerging risks and monitor our business activities and internal environment.

ROCC conducts an annual risk review to assess principal and emerging risks for the company. This review is supported by extensive analysis of external trends and insights, senior-level interviews and recommendations from risk management and compliance boards and risk owners. ROCC shares this annual review with the ARC and Board for assessment, forming the basis for the following year’s risk management focus.

## Enabling effective risk management, in line with our culture

We define enterprise risk plans that include a description of the risk, its context, our assessment, risk appetite, how we will treat the risk, and the actions businesses need to take in line with our internal control framework to mitigate the risk. These plans enable our Board committees to assess the effectiveness of our risk management strategies.

We report risks to ROCC and the Board committees every quarter, to drive more dynamic, data-driven discussions, agile risk management strategies and oversight. We report on existing control measures, implementation, emerging risks, external insights and key risk indicators, with risk reporting thresholds aligned to risk appetite. We include risks and mitigations associated with relevant events around us, such as COVID-19 and geopolitical tensions.



## Risk management continued

Our Code sets out the overarching expectations for our employees and complementary workers. Our risk management framework complements our culture and Speak Up processes in making sure that we identify and mitigate risks effectively. We monitor our most important risks and take action to address issues. Our annual confirmation exercise checks that key risks are well managed, or that actions are in place to address gaps. Our principal risks include controls for responding to problems within their risk plans. We also have business continuity planning embedded in our framework and our critical processes, so we can continue business operations in the event of a crisis.

## Our current risks

The table starting on page 53 shows our current principal risks and respective trends, assessments and mitigation activities for the year. These are not in order of significance. For full risk definitions, potential impact, context and mitigating activities, see Principal risks and uncertainties on pages 285 to 295. The Separation principal risk was removed in July 2022 following successful demerger and analysis of any residual risk.

Other risks, not at the level of principal risks, and opportunities, related to ESG, including environmental sustainability and climate change, are managed through our six focus areas, as described in our ESG Performance Report. Additional information on climate-related risk management is in our climate-related financial disclosures, see pages 55 to 61.

## COVID-19 pandemic

The potential impact of the COVID-19 pandemic on GSK’s trading performance and all its principal risks is continually assessed, with appropriate mitigation plans put in place on an as-needed basis. In 2022, GSK was encouraged by the uptake of its vaccines and medicines. The company remains confident in the underlying demand for its vaccines and medicines, especially given the significant number of COVID-19 vaccinations and boosters administered worldwide. However, the pandemic remains a dynamic ongoing risk, with the WHO continuing to monitor the emergence of new variants. The current rate of infection is predominantly driven by the circulation of the BA.5 subvariant and its descendant lineages, which are still the dominant subvariants of Omicron globally. While COVID-19 vaccines are being updated with Omicron variants to provide broader immunity against circulating and emerging variants, these subvariants and potential future variants of concern could potentially impact GSK’s trading results, clinical trials, supply continuity and its employees materially.

## Changes to our risks for 2023

In our December 2022 annual risk review, the ARC agreed to ROCC’s recommendation of our principal risks for 2023, which remain largely unchanged. We identified a new principal risk, Legal Matters, which brings into greater focus a range of legal risks. As a result, Anti-bribery and Corruption will no longer be a stand-alone principal risk in 2023. Additionally, we expanded our Information Security principal risk to explicitly include cyber risks. We also identified data management as a new emerging risk for 2023, which we will evaluate during the year. The 2022 emerging risks of geopolitical tensions and healthcare reform were embedded in our risk management activities throughout the year and will not be reported separately for 2023.

+ Viability statement, see page 64

+ ARC report, see page 124

+ Internal control framework, see page 125

+ Legal proceedings, see page 265

+ Environment, see page 45

+ Climate-related financial disclosures report, see page 55



## 2022 Principal risks summary

<table><tr><td>Risk</td><td>Trend versus prior year</td><td>Assessment and mitigation activities</td></tr><tr><td>Patient safety</td><td>→ External</td><td>The external risk environment remains stable. The regulatory environment remains challenging, with recent examples of evolving regulatory requirements related to safety reporting for clinical trials. Also, there is a risk that external parties, including regulatory agencies and technology companies, may reach conclusions and communicate information about the safety of our products based on real-world evidence that is not available to us. This could inhibit our ability to make timely decisions and take appropriate action in relation to the safety of our products, or to confirm or refute conclusions asserted by external parties. Our risk exposure remains stable. We continue to balance resources between change programmes while maintaining routine activities. In 2022, we’ve allocated resources to optimise pharmacovigilance operations, advance innovative solutions for safety case management, and simplify key safety processes. Change initiatives have the short-term potential to distract focus from our key business priorities. However, such changes will reduce our overall risk exposure by increasing workload capacity and organisational capability.</td></tr><tr><td>Product quality</td><td>→ External</td><td>The external risk environment is stabilising and remains high following COVID-19, with regulators resuming multiple on-site inspections to check that product quality expectations are met. There continues to be a focus on data governance and data integrity requirements, and on evaluation of products for the presence of nitrosamines. The regulatory environment is evolving with respect to continued use of titanium dioxide in medicines, with the EMA due to make a decision on potential discontinuation in 2024. Our risk exposure has stabilised as we return to pre-pandemic levels of health authority inspections. We continue with inspection readiness programmes to ensure full preparedness. We’ve continued to invest in technology and digital platforms to strengthen our controls around good data management practices. We’ve completed all nitrosamine product assessments in line with regulatory expectations.</td></tr><tr><td>Financial controls and reporting</td><td>↑ External</td><td>The external risk environment remains challenging due to political uncertainty, proposed increases in the obligations of directors and auditors, increasing threats of cyber attacks and fraud, and increasing ESG disclosure requirements. Our risk exposure remains stable due to our ongoing focus on the resilience of personnel and the testing of our internal control framework. We implement optimal risk mitigation through transformational programmes, technology, centralised processes, and risk and control assessments, and maintain effective tax and treasury strategies. We continually strengthen our control frameworks and collaborate with external bodies on setting standards.</td></tr><tr><td>Anti-bribery and corruption (ABAC)</td><td>→ External</td><td>The external risk environment remains stable. The enforcement of anti-corruption laws and regulations remains a priority in many countries, in particular the US and the UK, with a continued focus on investigating the use of third parties to bribe foreign public officials. As a result, rigorous anti-bribery and corruption controls are expected. Disruption to global supply chains and the commercial pressures caused by higher-than-usual inflation rates may increase the risks of bribery and corruption in certain contexts in the coming years. Our risk exposure remains stable as we continuously improve our ABAC programme to make sure that our controls match evolving and emerging risks. We’ve enhanced our mandatory ABAC training for all employees, and we provide role- and risk-tailored ABAC training on an ongoing basis. We also impose stringent ABAC training requirements on certain third parties who provide services for or on our behalf.</td></tr><tr><td>Commercial practices</td><td>→ External</td><td>The external risk environment has stabilised. Macroeconomic factors such as energy price increases, inflationary pressure, and ongoing effects of the COVID-19 pandemic contribute to a challenging environment for all stakeholders. Competitive pressure remains intense across therapy areas and market segments. Governments remain focused on initiatives to drive down medicine and vaccine costs for consumers. Our risk exposure remains stable. We have a mature and robust control environment, which has evolved to match the competitive enhancements to our commercial practices, including higher volumes of engagement with healthcare professionals and strengthened sales force incentive schemes.</td></tr></table>



## 2022 Principal risks summary continued

<table><tr><td>Risk</td><td>Trend versus prior year</td><td>Assessment and mitigation activities</td></tr><tr><td>Scientific and patient engagement</td><td>→ External</td><td>The external risk environment remains stable. It continues to be characterised by complex, dynamic disease areas and treatments with increased patient-centric focus during all phases of the product lifecycle, increasing diversity of engagement platforms and more virtual engagements.</td></tr><tr><td></td><td>→ GSK</td><td>Our risk exposure remains stable. We continue to mitigate risk by modernising and adjusting our engagement practices and internal controls to the rapidly evolving environment. We have internal networks to foster collaboration and best practice sharing, as well as the identification of emerging risks associated with scientific and patient engagement activities.</td></tr><tr><td>Data ethics and privacy</td><td>↑ External</td><td>The external risk environment continues to increase as the global landscape of data protection, privacy and cyber laws develops. Given that the current pace of technology-focused innovation is expected to continue, companies need to be mindful of relevant potential legislation and regulations. The increasing trend for data sovereignty, initially affecting tech companies, could affect healthcare companies in their ability to drive medical innovation and to effectively operate internationally.</td></tr><tr><td></td><td>↑ GSK</td><td>Our risk exposure is increasing in the context of an unstable privacy regulatory environment and our multinational footprint, as we re-align with our digital transformation and focus on data-driven science. Laws in our key markets such as the US, EU, UK, China and India continue to evolve, including those relating to international data transfer mechanisms.</td></tr><tr><td>Research practices</td><td>→ External</td><td>The external risk environment remains stable. Research remains critical to the development of safe and effective products. Advances in technology, use of data, societal expectations and ethical considerations and new entrants to the sector continue to influence the environment. Global regulations and quality standards continue to evolve, and are particularly impactful when expectations change or there are country-specific requirements.</td></tr><tr><td></td><td>→ GSK</td><td>Our risk exposure remains stable, as laws and regulations are continually evolving. We continue to perform robust risk scanning and assessments that inform the evolution of our control framework in response to regulatory changes, ensuring clear accountabilities for actions.</td></tr><tr><td>Environment, health and safety (EHS)</td><td>→ External</td><td>The external risk environment remains stable. Manufacturing sites are operating at full staffing levels. Work location arrangements have been made to maintain the safety and wellbeing of employees affected by the Ukraine conflict.</td></tr><tr><td></td><td>→ GSK</td><td>Our risk exposure remains stable. We&#x27;ve continued to focus on safety leadership training, embedding our Life Saving Rules, and adhering to our EHS standards. We&#x27;re introducing our Safety Leadership Experience across Global Supply Chain, and R&amp;D operations. This programme trains leaders to take EHS accountability and make sure all our people understand the importance of adhering to our EHS standards.</td></tr><tr><td>Information security</td><td>↑ External</td><td>The external risk environment continues to rise as digital footprints increase and threats from hackers become more sophisticated. Growing geopolitical conflicts have significantly increased cyber risk to large corporations. Governments are tightening regulatory frameworks with regards to data and information, and we are seeing a rise in enforcement of them.</td></tr><tr><td></td><td>↑ GSK</td><td>Our risk exposure continues to increase as we operate in an increasingly digital healthcare ecosystem and continue to expand our own digital footprint. In response, our cyber security maturity programme continues to improve our controls and governance to identify, protect, detect, respond to and recover from cyber incidents.</td></tr><tr><td>Supply continuity</td><td>↑ External</td><td>The external risk environment is increasing due to unpredictable external forces that put pressure on the resilience of our supply chains. These include geopolitical tensions and growing nationalistic approaches (including US-China decoupling).</td></tr><tr><td></td><td>→ GSK</td><td>Our risk exposure remains stable. Across our Medicines and Vaccines supply chains, we continue to focus on strategic materials planning parameters, adapting to changes in the external environment, including inventory strategies, safety stocks and hedging. We&#x27;re making a concerted effort to stabilise and accelerate newly acquired assets and we&#x27;re focusing on making sure we recruit the right people to support our future portfolio.</td></tr></table>



## Climate-related financial disclosures

GSK climate-related financial disclosures are consistent with the recommendations and recommended disclosures of the Task Force on Climate-related Financial Disclosures (TCFD) including the TCFD all-sector guidance, and in compliance with the requirements of LR 9.8.6R.(8) (UK Listing Rules).

GSK has been reporting on climate-related financial disclosures in accordance with the TCFD recommendations since 2019, with the purpose of building trust and connecting both our strategic and financial disclosures to climate change. This year we have updated the climate scenarios used to model transition and physical risks, which enabled us to extend the timeframe to model risks to 2050 where data was available and to broaden the scope to include GSK’s supply chain. We will continue to monitor for emerging risks and new data to include in future assessments.

## Governance

## Board

The Board considers climate-related matters throughout the year assessing the risk management processes in place and challenging and endorsing the business plan and budgets, including overseeing major capital expenditures, acquisitions and divestments. The Committee that exercises oversight, provides guidance and reviews our ESG performance, including climate-related risks and opportunities, and environmental performance against targets is the CRC.

The Committee is supported by GLT and ROCC which receive quarterly updates on environmental sustainability, including climate. Regular attendees include the CEO, and the President Global Supply Chain. See the CRC report on page 107 for further details of the Board architecture.

In 2022 the CRC met four times. Key areas of focus were:

– discussed climate-related issues on three separate occasions with management, including: progress in delivering against our climate ambitions; implications of the geopolitical landscape; key milestones and decisions required to achieve net zero targets

– reviewed mid-year performance for key environmental metrics, including climate-related metrics, as part of reviewing GSK’s ESG Performance Rating

– approved GSK’s TCFD statement and public environmental reporting and disclosures

In 2022 the Remuneration Committee, with the support of the CRC, introduced a 10% measure into GSK’s long-term incentive plan opportunity for senior leaders based on key metrics related to GSK’s ESG performance.
These metrics include climate-related metrics such as reduction in scope 1 & 2 emissions and reaching key milestones in the R&D programme to reduce greenhouse gas emissions (GHG) in metered dose inhalers for asthma and chronic obstructive pulmonary disease, see page 148.

## GSK Leadership Team (GLT)

The GLT meets regularly and is an opportunity for members to discuss strategic, financial and reputational matters.

Regis Simard, President, Global Supply Chain and GLT member has management responsibility for environmental sustainability, which includes climate change. He is responsible for governance and oversight of risks and opportunities and ensures there is an effective framework in place to manage the risks and opportunities across each of our business units along with delivering on the commitments made to a net zero, nature positive, healthier planet, with ambitious goals set for 2030 and 2045 across our entire value chain.

Regis is supported by GSK’s Vice President (VP) Sustainability who regularly reviews progress with him and who co-chairs the quarterly GSK Sustainability Council.

In 2022 GLT reviewed and discussed the mid-year performance for key environmental metrics, including climate-related ones, as part of reviewing GSK’s ESG Performance Rating.

## GSK Sustainability Council

The Sustainability Council, held quarterly, is attended by senior leaders from across the business who play a key role in delivering our commitment to a net zero, nature positive, healthier planet, with ambitious goals set for 2030 and 2045 across our entire value chain. Members include leaders from procurement, finance, HR, Compliance, R&D and manufacturing. The Council is co-chaired by the President Global Supply Chain and the VP Sustainability and supported by the global sustainability team who provides specialist expertise and advice to the business.

## In 2022 the Council:

– received monthly performance dashboards covering key performance metrics and escalations of any potential concerns or issues

– held quarterly performance reviews across all areas of programme delivery and focused reviews of aspects of the programme such as the implementation of the sustainable sourcing strategy, and recommendations for refreshing GSK’s Science Based Target commitments. The Council reviews include decisions on interventions or support required to maintain progress towards 2030 targets

– reviewed insights on ESG trends and regulations

– approved the proposed Sustainability Data Strategy



## Risk management continued

In order to address the key priorities of the climate impact from GSK’s metered dose inhaler, a specific council was established in 2022 and is attended by senior leaders from across the commercial, supply chain, regulatory and R&D businesses aligned to GSK’s respiratory business. This council is chaired by the President Global Supply Chain and is the decision-making body for:

– the programme to reduce the climate impact of metered dose inhalers which contribute to approximately 50% of GSK’s total GHG emissions by up to 90%, if the clinical trials are successful

– advocacy and engagement with regulators and policymakers

– industrialisation strategy and progress

## Other business support

– the Sustainability Programme Steering Team co-ordinates the sustainability programme and associated workstreams and has oversight for monitoring performance and progress of the enablers required to deliver the sustainability programme

– business unit sustainability councils meet quarterly to review business unit performance and delivery against the company sustainability ambition

– the Capital Allocations Board (CAB) which includes the CFO and Group Financial Controller reviews climate-related capital expenditure as part of its annual planning and capital allocation process

– the Finance Sustainability Network includes leaders from across Finance, Sustainability and Procurement and focuses on key financial enablers to deliver the sustainability programme

## Strategy

GSK's commitment to a net zero, nature positive, healthier planet is embedded in GSK's strategic long-term priorities, always considering the social, environmental and governance impacts of everything we do from laboratory to patient.

There are many teams across GSK involved in this process, to ensure that we make sound strategic decisions. The process for identifying and assessing climate-related risks and opportunities is set out under Risk Management as part of this TCFD section. To achieve our climate ambition, active holistic management of all climate-related risk components is important. In addition to risk, we also continue to identify opportunities for GSK. These risks and opportunities are described further in the table on pages 58 and 59.

In order to achieve reductions in emissions across our operations by 2030, as part of our transition plans, we are focusing on:

– maximising energy efficiency in our sites

– transitioning to 100% renewable electricity by 2025

– increasing the use of electric vehicles by our sales fleet
Supply chain emissions are a shared challenge across our sector, and we are working with our peers on collaborative initiatives such as:

– the Activate programme to help Active Pharmaceutical Ingredients (API) suppliers accelerate decarbonisation initiatives

– the Energize programme to encourage the use of renewable energy throughout the pharmaceutical sector’s supply chain

– the Manufacture 2030 initiative to encourage suppliers to measure, manage and reduce their emissions

In September 2022, we launched a Sustainable Procurement Programme which will require our suppliers to disclose emissions and set carbon reduction targets aligned with 1.5°C.

The use of our metered dose inhalers by patients for asthma and chronic obstructive pulmonary disease makes up around 50% of our total climate impact. We are investing in an R&D programme to reduce greenhouse gas emissions from this vital medicine that could potentially reduce the climate impact by up to 90%. If the clinical studies confirm that the new propellant could be an appropriate replacement, GSK will work on securing approval from regulators in markets where the new product could be made available to patients. This process can take time, but GSK is focused on meeting our commitment and we have made considerable investments towards achieving this goal.

The Science Based Targets initiative (SBTi) accredited our climate targets, set prior to our demerger, as aligned to the 1.5°C pathway. Our reduction pathway to 2030 is significantly more ambitious and we are currently seeking reaccreditation from the SBTi for our targets as a fully focused biopharma company.

We recognise that the global energy crisis as described on page 13 is disrupting and delaying the green transition across the world. This may impact the pace of decarbonisation in the short term but any setback to the energy transition is expected to be time-limited.

In 2021, we developed a three-year plan to further embed climate risk analysis across material areas of our business and focused on risks impacting our direct operations. In 2022, we updated the climate scenarios used to model transition and physical risks, which enabled us to extend the timeframe to model climate risks out to 2050 where data was available and to broaden the scope to include GSK's sites and suppliers across all geographies with a strategic revenue dependency aligned to other supply chain risk management processes.



## Risk management continued

We will continue to monitor for emerging risks and new data to include in future assessments, using external parties to provide horizon scanning insights on ESG trends and regulations.

GSK prioritised scenario modelling of the following risks in 2022:

– changes to regulations governing the supply of high global warming potential (GWP) substances by the EU, UK and US governments could restrict GSK’s ability to manufacture metered dose inhalers

– future regulatory policy responses to address climate change could lead to the imposition of carbon taxes by countries where GSK manufactures and sources goods from third parties

– increasing levels of water stress that could lead to interruptions to supply of water to GSK and third-party supply sites

– increasing frequency and impact of extreme weather events that could cause disruption to GSK and third-party supplier sites

## Climate scenarios

We reviewed and updated our climate scenarios, developing four climate scenarios. We used three of these scenarios for modelling transition risks (Net Zero, Low Carbon and Current Trajectory), and three scenarios for modelling physical risks (Low Carbon, Current Trajectory, and Breach of Planetary Boundaries).

## Net zero scenario (SSP 1 – RCP 1.9)

This scenario sets out a narrow but achievable pathway for the global energy sector to achieve net zero  \( CO_{2} \)  emissions by 2050 \( ^{1} \) . It does not rely on emissions reduction from outside the energy sector to achieve its goal. The scenario is consistent with limiting the global temperature rise to 1.5°C without a temperature overshoot. Net zero means huge declines in the use of coal, oil and gas and a shift to renewable energy sources.

## Low carbon scenario (SSP 1 – RCP 2.6)

In this scenario, all current net zero pledges are achieved in full and there are extensive efforts to realise near-term emissions reductions; advanced economies reach net zero emissions by 2050. China around 2060, and all other countries by 2070 at the latest \( ^{2} \) . The scenario is consistent with limiting the global temperature rise to below 2°C. With some level of net negative emissions after 2070, the temperature rise could be reduced to 1.5°C in 2100.

## Current trajectory scenario (SSP2 – RCP4.5)

This scenario sets out to show to what extent announced ambitions and targets are on the path to deliver the emissions reductions required to achieve net zero emissions by 2050 \( ^{3} \) . The temperature rise will exceed 2°C by 2100, with a more noticeable shift to happen in the latter half of the century. A net zero pledge for emissions within the scenario does not necessarily mean that  \( CO_{2} \)  emissions from the energy sector need to reach net zero, there is an allocation for carbon offsetting within the pledges.

## Breach of planetary boundaries scenarios (SSP 5 – RCP 8.5)

This scenario is not aligned to any of the pledges laid out within the Paris Agreement and is one where countries are unable to meet the United Nations Sustainable Development Goals. This scenario will have the most severe physical consequences for the planet. The temperature rise will exceed  $ 4^{\circ} \) C by 2100, leading to high loss of biodiversity and species extinction.

Each risk and opportunity was analysed including how they are being managed by GSK and the metrics and targets in place and the potential impact on our profit using a low ( $ \leq $ 100 million), medium ( $ \leq $ 100 million- $ \leq $ 250 million) or high ( $ \geq $ 250 million) threshold.

Due to the inherent uncertainty, and the nature of the risks across GSK strategy and business model, the climate-related issues are monitored within these time horizons: short term (less than 3 years); medium term (3–10 years) and long term (> 10 years).

In comparison to the 2021 disclosure, we have extended the timeframe for climate risk assessments out to 2050 where data is available to be able to differentiate between the potential long-term outcomes in different climate scenarios.

Based on the different climate scenarios analysis performed and taking into consideration the climate risk and opportunities identified across all geographies, as described in the table below, we have tested the resilience of GSK's business strategy and did not identify any material impact to our business resilience.



## Risk management continued

<table><tr><td>Physical risk/ description</td><td>GSK response</td><td>Scenario</td><td>Potential financial impact/ timeframe</td><td>Metrics</td><td>Targets</td></tr><tr><td>The risk from increasing levels of water stress leading to interruptions to supply of water to GSK sites and third-party supply sites.</td><td>We have identified three water basins in water-stressed areas in Algeria, India and Pakistan where we have manufacturing sites, and where we aim to be water neutral. At our manufacturing facility in Nashik, India we have built plants for rainwater harvesting. The climate scenario analysis has identified a number of sites and supplier sites located in water basins that could become water stressed by 2040 which have been added to a watch list. We will monitor changes to the risk levels and update our site water risk assessments appropriately.</td><td>Current trajectory</td><td>Medium (£100m-£250m/ Long term (&gt; 10 years)</td><td>Sites that have achieved water stewardship</td><td>Achieve good water stewardship at 100% of our sites by 2025</td></tr><tr><td>GSK and its third-party suppliers use freshwater as the main source of water to manufacture medicines and vaccines. If water availability was restricted at a factory, then production operations would be interrupted.</td><td></td><td>Breach of planetary boundaries</td><td>Low (&lt; £100m)/ long term (&gt; 10 years)</td><td>Total supplied water</td><td>Reduce overall water use in our operations by 20% by 2030</td></tr><tr><td>Increasing frequency of extreme weather events causing disruption to GSK and third-party supplier sites.</td><td>The climate scenario modelling indicated that of the seven physical perils, flood from rainfall presents the highest likelihood of an acute interruption. However, the risk of flooding from rainfall and from the other extreme weather events is expected to remain very low.</td><td>Low carbon scenario</td><td></td><td>Business continuity plans are reviewed annually</td><td>Where climate-related risks to business continuity are identified, we have taken action to mitigate the risk</td></tr><tr><td>Extreme weather events from any one of precipitation (rainfall), flood from precipitation, tidal flood, extreme wind, wildfire, extreme heat or extreme cold can result in short-term interruptions to manufacturing at GSK or supplier sites.</td><td>We have performed risk assessments for our manufacturing and other operations and have business continuity plans in place which are reviewed annually to respond to the impacts of extreme weather events including adopting appropriate mitigation plans.</td><td>Current trajectory scenario</td><td>Low (&lt; £100m)/ Long term (&gt; 10 years)</td><td></td><td></td></tr><tr><td>Regulations governing the use of high global warming potential (GWP) substances are being updated in the EU and UK and were updated recently in the US.</td><td>GSK has a well established loss prevention and risk engineering programme to identify a range of risks that could impact our sites and where flood risks exist, we have taken action to mitigate the risk.</td><td>Breach of planetary boundaries scenario</td><td></td><td></td><td></td></tr><tr><td>This could lead to increasing costs and restrict the ability to manufacture our metered dose inhaler (MDI) products that use a high GWP propellant (HFAI34a).</td><td>We are investing in an R&amp;D programme to reduce greenhouse gas emissions from metered dose inhalers used to treat asthma and COPD and have made good progress towards reformulating an alternative gas that could potentially reduce the climate impact by up to 90%, if the clinical trials are successful.</td><td>Current trajectory scenario</td><td>High (&gt; £250m)/ medium (3-10 years)</td><td>On/off track against delivery of key milestones on the R&amp;D programme plan</td><td>80% and 90% reduction in carbon emissions (all scopes) by 2030 and 2045, respectively</td></tr></table>



## Risk management continued

<table><tr><td>Transitional risk/ description</td><td>GSK response</td><td>Scenario</td><td>Potential financial impact/ timeframe</td><td>Metrics</td><td>Targets</td></tr><tr><td rowspan="3">Future regulatory policy responses to address climate change could lead to the imposition of carbon taxes by countries where GSK manufactures and source goods from third parties.</td><td>GSK is managing this risk by reducing Scope 1 and 2 emissions through the following:
- GSK&#x27;s energy efficiency programme
- Transitioning to 100% renewable electricity by 2025
- Investigating options for renewable heat technology
- Transitioning sales fleet to electric vehicles by 2030
- Using shadow carbon pricing on capital investments of US$ 100 per tonne of GHG emissions</td><td>Net zero scenario</td><td>Medium (£100-250m) in both medium (3-10 years) and long term (&gt; 10 years)</td><td>Scope 1 &amp; 2 carbon emissions
Scope 3 carbon emissions</td><td>80% and 90% reduction in carbon emissions (all scopes) by 2030 and 2045, respectively</td></tr><tr><td>GSK is managing this risk by reducing Scope 3 emissions through the following:
- R&amp;D programmes to reduce greenhouse gas emissions from metered dose inhalers
- The new supply chain programme requiring our suppliers to take action on carbon, set targets aligned with 1.5°C and switch to renewable power and heat
- Collaborating with sector peers in the Enerqize and Activate programmes and the Manufacture 2030 initiative
- Joining the Sustainable Markets Initiative Health Systems Task Force to reduce healthcare supply chain emissions</td><td>Low carbon scenario</td><td>Medium (£100-250m) in the medium (3-10 year) term falling to low ( \( &lt; $ 100m) in the long term (&gt; 10 years)</td><td>Low ( \( &lt; $ 100)/ in the medium (3-10 years) and long term (&gt; 10 years)</td><td></td></tr><tr><td>Opportunities</td><td>GSK response</td><td>Scenario</td><td>Potential profit impact/ timeframe</td><td>Metrics</td><td>Targets</td></tr><tr><td>At COP26 in November 2021, more than 50 countries around the world committed to provide low carbon healthcare systems.</td><td>We are reducing our own Scope 1 &amp; 2 carbon emissions which in turn reduces the Scope 3 footprint of our customers and suppliers; for example, at our site in Irvine in Scotland, a closed loop heat system has helped to drive reductions in operating costs, and onsite renewables and biogas will provide 85% of its energy.</td><td>Net zero scenario</td><td>Low carbon scenario</td><td>Scope 1 &amp; 2 and 3 carbon emissions</td><td>80% and 90% reduction in carbon emissions (all scopes) by 2030 and 2045, respectively</td></tr><tr><td>This could lead to increasing demand for low carbon medicines and vaccines.</td><td>We have an Eco-design programme to reduce the impacts of all our products and packaging. We are investing in an R&amp;D programme to reduce greenhouse gas emissions from metered dose inhalers used to treat asthma and COPD and have made good progress towards reformulating an alternative gas that could potentially reduce the climate impact by up to 90% if the clinical trials are successful.</td><td>Current trajectory scenario</td><td>Low ( \) &lt;100m/ Long (&gt; 10 years)</td><td>Total waste and materials</td><td>Zero operational waste</td></tr><tr><td>There have been several reports exploring the impact of climate change and health showing that climate change affects water- and vector-borne diseases.</td><td>We have a portfolio of dry powder inhaler products that have low carbon footprints.</td><td>Current trajectory scenario</td><td>Long (&gt; 10 years)</td><td>Not applicable</td><td>Not applicable</td></tr><tr><td>This could lead to an increasing demand for new medicines and vaccines.</td><td>In September 2022, GSK and Microsoft announced an innovative collaboration with the Centre for Health and Disease Studies (CHDS) Nepal. The pilot project, which will leverage Microsoft&#x27;s Premotion systems and GSK&#x27;s expertise in health and disease, will investigate how AI and robotics can support local community response to vector-borne diseases and climate change.</td><td>Current trajectory scenario</td><td>Long (&gt; 10 years)</td><td>Not applicable</td><td>Not applicable</td></tr></table>



## Risk management continued

## Risk management

As described in the Risk management section on page 51, GSK’s risk management policies are designed to address all types of risks, including the Group principal risks and uncertainties and our climate risk assessment follows the same policy and framework.

The nature of the risks and opportunities from climate change depends not only on the physical aspects of climate change, but also regulatory and commercial changes in the markets in which GSK operates, including pressures to reduce the climate impact of GSK’s metered dose inhaler medicines.

In terms of GSK climate risk management policies, a specific and dedicated environmental sustainability risk management plan was put in place in 2020. The risk management plan covers expectations that GSK is addressing its impact on the environment, and that the environment has increasing impacts on operational resilience such as access to energy, water and the natural resources used in products, along with any anticipated cost increases from regulatory changes or environmental taxes. Policy developments at global and national level are monitored for their potential impact. For example, as a result of the UN Montreal Protocol 2016 Kigali amendment that mandates a global phase down of the use of high global warming potential hydrofluoroalkane gases, governments are introducing or proposing to introduce quota restrictions to HFA134a that is used by GSK to manufacture metered dose inhalers used to treat asthma and COPD. GSK has been part of an industry consultation with the UK Department for Environment, Food & Rural Affairs as the UK government develops its UK specific regulations on the control of F-gases.

GSK has policies and procedures in place to identify risks from climate change when things change, for example to assess the climate impact of merger and acquisition activity, or the construction of new buildings, or major capital expenditure. Furthermore, an internal control framework has been established for environmental sustainability, including the appointment of dedicated senior leaders for environmental sustainability to ensure that governance processes are in place and effective.

For the purposes of our TCFD disclosures we have made use of the TCFD distinction between “physical” and “transition” climate-related risk.

Risks which may be identified include potential effects on operations at asset level, performance at business level and developments at regional level from extreme weather or the transition to a lower carbon economy.
Physical risks are typically identified at the asset or project level and are managed depending on the level of risk assessed. Increasing levels of water stress is a physical risk and could reduce the availability of water for our operations in affected locations. This is an important risk as GSK uses freshwater as the main source of water to manufacture medicines and vaccines. If water availability was restricted at a factory, then production operations could be interrupted. We perform water stewardship risk assessments for our manufacturing sites and update them every three years.

Transition risks are typically identified at enterprise level and at market level. Currently the transitions risks which are a priority for GSK are regulatory and commercial risks which we manage through our investment decisions and through our sustainability transformation programme. From a legal point of view, we consider risks which may arise from product claims based on environmental performance. To manage this risk, we use external accreditation processes and organisations to review the evidence used to support environmental claims for our products criteria. From a technological point of view, GSK has developed tools to incorporate eco-design principles into the design and development of new products and to identify opportunities to reduce the environmental impacts of existing products. Our communications and governance affairs team manages corporate reputation through identification and monitoring of climate-related issues and then undertake both proactive and reactive engagement with relevant stakeholder groups to communicate GSK’s position.

On an annual basis a cross-functional team from GSK’s business units, sustainability team and finance perform a review of risks from climate change to identify any new or emerging risks and to determine if an updated risk assessment is required for any existing risks. Climate-related risks are considered from a strategic and operational perspective to ensure we maintain a comprehensive view of the different types of climate risks we face and the different time horizons in which they may affect GSK. This review is approved by the VP Sustainability and Finance VPs from each of GSK’s business units.

The identified risks are assessed by a climate risk working group who consider the likelihood and financial impact of each risk on GSK under different climate scenarios. The impact assessments are approved by the President, Global Supply Chain who has company level responsibility for Environmental Sustainability, the VP Sustainability and Finance VPs from each of GSK’s business units. The results are shared with Business Unit Risk Management Control Boards (RMCB) and the Finance RMCB to ensure risks are both contextualised with other business risks and managed appropriately. This allows management to take a holistic view and optimise risk mitigation responses, to ensure that responses to climate-related risks are properly integrated into the relevant businesses’ and functions’ activities.



## Risk management continued

## Metrics and targets

GSK commits to a net zero, nature positive, healthier planet, with ambitious goals set for 2030 and 2045 across our entire value chain. GSK reports progress in reducing Scope 1 & 2 carbon emissions, Scope 3 carbon emissions \( ^{1} \) , energy use, water, waste annually in our ESG Performance Report for detailed performance data and other environmental KPI and in our public responses to the CDP Climate, Water and Forest questionnaires.

a. Disclose the metrics used by the organisation to assess climate risks and opportunities in line with its strategy and risk management process
GSK has considered the key metrics following the guidance of Tables A1.1 and A1.2 as well as the metrics consistent with cross-industry, climate-related metrics as described in TCFD. Based on that, our strategic metrics are:

– Scope 1 & 2 emissions (market-based and location-based approach), described in the table below

– Scope 3 emissions, described in the table below

– % renewably sourced electricity, described in the table below

– Total supplied water, described in the table below

– Total waste and materials, described in the table below

– ESG composite metric, as part of our senior leaders' remuneration policy see page 148

– Sites that have achieved water stewardship, described in the table below

Our ESG Performance Report includes additional metrics used to support the strategic metrics listed above.

b. Disclose Scope 1, 2 and if applicable
Scope 3 GHG
emissions and
related risks
In Energy and carbon emissions, see table below

– Scope 1 emissions from energy

– Scope 1 from other sources

– Scope 2 emissions (market-based)

– Scope 2 emissions (location-based)

– Scope 3 emissions metrics

– Scope 1 & 2 emissions from intensity metrics

Prioritised physical and transition risks are included in the Strategy Section on page 56.

c. Describe the targets used by the organisation to manage climate-related risks and opportunities and performance against targets
Our targets (measured against a 2020 baseline where applicable) are:

– 80% reduction in carbon emissions and investment in nature-based solutions for the remaining 20% of our footprint by 2030 (all scopes)

– 100% renewable electricity by 2025 (Scope 2)

– Net zero emissions across our full value chain by 2045 (all scopes)

– Achieve good water stewardship at 100% of our sites by 2025

– Reduce overall water use in our operations by 20% in 2030

– Zero operational waste by 2030.

– Be water neutral in our own operations and at key suppliers in water-stressed regions by 2030

The performance against our targets can be found on pages 45 and 46. \( ^{1} \)



## Metrics data

## Carbon emissions \( ^{1,2} \) 

<table><tr><td>Carbon emissions 000 tonnes CO2e</td><td>2022</td><td>2021</td><td>2020</td></tr><tr><td>Scope 1 emissions (from energy)</td><td>320</td><td>333</td><td>355</td></tr><tr><td>Scope 1 emissions (other \( ^{3} \) )</td><td>306</td><td>300</td><td>358</td></tr><tr><td>Scope 2 emissions (market-based)</td><td>88</td><td>131</td><td>169</td></tr><tr><td>Scope 2 emissions (location-based)</td><td>265</td><td>285</td><td>309</td></tr><tr><td>Scope 3 emissions \( ^{4} \)</td><td>—</td><td>8,624</td><td>9,949</td></tr><tr><td>UK Scope 1 &amp; 2 emissions</td><td>111</td><td>126</td><td>138</td></tr><tr><td>Other metrics</td><td>2022</td><td>2021</td><td>2020</td></tr><tr><td>Scope 1 and 2 emissions from energy/sales revenue (tonnes CO2e/ \( \text{Em} \) )</td><td>13.9</td><td>18.8</td><td>21.5</td></tr><tr><td>Scope 1 and 2 emissions from energy/FTE (tonnes CO2e/FTE)</td><td>5.9</td><td>6.5</td><td>7.2</td></tr><tr><td>Total energy used (GWh)</td><td>2,759</td><td>2,871</td><td>3,085</td></tr><tr><td>UK energy used (GWh)</td><td>735</td><td>807</td><td>917</td></tr><tr><td>% renewably sourced electricity</td><td>73%</td><td>63%</td><td>46%</td></tr><tr><td>Total supplied water million m \( ^{3} \)</td><td>7.5</td><td>7.9</td><td>9.7</td></tr><tr><td>Total waste and materials 000 metric tonne</td><td>57.2</td><td>63.1</td><td>63.0</td></tr><tr><td>% sites that have achieved water stewardship</td><td>100%</td><td>100%</td><td>89%</td></tr></table>

1 All data reported excludes our previous Consumer Healthcare business unless otherwise specified

2 Carbon emissions are calculated according to the Greenhouse Gas Protocol: A Corporate Accounting and Reporting Standard (revised edition). GSK uses market-based Scope 2 emissions for reporting purposes and reports Scope 3 emissions across all 15 categories in our ESG Performance Report. We ask external assurance providers, Deloitte, to provide limited assurance to ISAE 3000 for energy. Scope 1, 2 and selected Scope 3 carbon emission data, water and wastewater data. Methodologies for reporting and measurements are provided in the Basis of Reporting 2022 in the ESG resources section of gsk.com (https://www.gsk.com/en-gb/responsibility/esg-resources/)

3 'Other' refers to emissions from sales force vehicles, propellant emissions released during manufacture of inhalers (the majority of propellant emissions, released during patient use, are included in Scope 3 carbon emissions), on-site waste, or wastewater treatment and refrigerant gas losses

4 We collect and publish Scope 3 data across 15 categories. The most recent Scope 3 data available is for 2021 as the process of compiling the 2022 data is not yet complete, except for 2022 Scope 3 emissions from patient use of inhalers which are disclosed in the ESG Performance Report. We will publish this data once it becomes available and it will be included in the 2023 ESG Performance Report

## Nature-related financial disclosure

At GSK we are committed to playing our part to minimise our impact and dependencies on nature, as well as helping to protect and restore nature. We have performed a full assessment of our impacts on nature across our value chain and are setting targets to reduce these pressures in line with evolving guidance from Science Based Targets for Nature (SBTN). In line with our commitment to nature and building on the achievements of our climate-related financial disclosures, GSK is currently piloting the recommendations of the Taskforce on Nature-related Financial Disclosures (TNFD) ahead of the launch of the TNFD's final framework expected in September 2023.

As part of the pilot, we are working to understand how we can utilise the TNFD guidelines to report the risks that our impacts and dependencies on nature present to our business. We are making an initial disclosure with a particular focus on strategy, metrics and targets. Some early findings from the results of our in-progress analysis are included below.

## Strategy

We are committed to have a net positive impact on nature by 2030 by reducing our environmental impacts across water, waste and materials biodiversity and by investing in nature protection and restoration. In 2022, we conducted an assessment of GSK’s nature-related risks and opportunities, in line with the latest TNFD guidance from November 2022. By following the latest TNFD LEAP (Locate, Evaluate, Assess and Prepare) methodology, we have been able to better understand the magnitude of GSK’s physical and transitional risks across each Nature pressure. We will continue to refine our assessment, following the methodology from TNFD, and will look to report against it once the final version is available.

Additionally, GSK is one of the first companies to conduct a materiality assessment for its full value chain, in line with the SBTN methodology, to better understand our impacts and dependencies.



## Risk management continued

This process has clearly indicated that to achieve Net Nature Positive by 2030 requires us to build a portfolio of pressure-specific initiatives that drive action in targeted landscapes and regions of impact. As part of our commitment, we acknowledge that collaboration across different stakeholders will continue to be an imperative in this multi-year journey. Ultimately, the direction provided by the SBTN technical guidance will help shape our strategy to ensure we minimise our impacts and dependencies on nature globally.

## Metrics and targets

To address GSK’s pressures on Nature, we have existing targets across water, waste, materials and biodiversity (see page 46).
Our targets will continue to evolve as we incorporate the findings of our materiality assessment and progress towards achieving Net Nature Positive by 2030. To support progress, we actively engage with external partners including the SBTN and World Business Council for Sustainable Development to ensure targets and metrics are meaningful and robust.

Addressing our impacts on the natural world and understanding the impacts of the changing state of nature globally on GSK is no small undertaking, but we are proud to be pioneering the use of nature-related financial disclosures in our industry. Ultimately, delivering positive outcomes for the environment is fundamental to delivering positive outcomes on human health. At GSK we are excited to continue on this path, uniting science, technology and talent to get ahead of disease together.

## Non-financial information statement

The following aligns to the non-financial reporting requirements contained in sections 414CA and 414CB of the Companies Act 2006.

<table><tr><td>Description of the business model</td><td>Human rights</td><td>Policy, due diligence and outcomes</td></tr><tr><td>Business model</td><td>Human rights</td><td>Risk management</td></tr><tr><td>Social matters</td><td>Working with third parties</td><td>Principal risks and uncertainties</td></tr><tr><td>Access</td><td>Data and engagement</td><td>Viability statement</td></tr><tr><td>Global health and health security</td><td>44</td><td>Audit &amp; Risk Committee report</td></tr><tr><td>Employees</td><td>Ethical standards</td><td>Non-financial key performance indicators</td></tr><tr><td>Our culture and people</td><td>Reporting and investigating concerns</td><td>2022 performance and key performance indicators</td></tr><tr><td>Employee engagement</td><td>Environmental matters</td><td>Our policies</td></tr><tr><td>Diversity, equity and inclusion</td><td>Environment</td><td>All of our public policies, codes and standards are available on gsk.com</td></tr><tr><td>Wellbeing and development</td><td>Climate-related financial disclosures</td><td>55</td></tr><tr><td>Gender pay gap</td><td>Nature-related financial disclosure</td><td>62</td></tr><tr><td>Ethical standards</td><td></td><td></td></tr><tr><td>Board diversity</td><td></td><td></td></tr></table>

## Employees by gender

<table><tr><td></td><td>Male</td><td>Female</td><td>Total</td></tr><tr><td>Board</td><td>8</td><td>3</td><td>11</td></tr><tr><td>Management \( ^{*} \)</td><td>8,318</td><td>8,201</td><td>16,519</td></tr><tr><td>All employees</td><td>36,782</td><td>32,618</td><td>69,400</td></tr></table>

* Senior managers as defined in the Companies Act 2006 (Strategic Report and Directors' Report) Regulations 2013



## Viability statement

In accordance with provision 31 of the 2018 revision of the Code, GSK has assessed the prospects of the Group over a longer period than the 12 months required by the 'Going Concern' provision. The Directors confirm that they have a reasonable expectation that GSK will continue to operate and meet its liabilities, as they fall due, over the next three years. The Directors' assessment has been made with reference to GSK's current position and prospects, our strategy, the Board's risk appetite and GSK's principal risks and how these are managed, as detailed on pages 51 to 54 in the Strategic report.

The Board reviews our internal controls and risk management policies and approves our governance structure and code of conduct. It also appraises and approves major financing, investment and licensing decisions, and evaluates and monitors the performance and prospects of GSK as a whole. The focus is largely on improving our long-term financial performance through delivery of our company's business strategies and aligned priorities.

The Board reviews GSK’s strategy and makes significant capital investment decisions over a long-term time horizon, based on a multi-year assessment of return on capital, the performance of the company, and the market opportunities in medicines and vaccines. This approach is aligned to GSK’s model of achieving balanced growth by investing in high quality, innovative products for patients and healthcare providers. However, since many internal and external parameters become increasingly unpredictable over longer time horizons, GSK focuses its detailed, bottom-up Plan on a three-year cycle. The Plan is reviewed at least annually by the Directors, who approve business forecasts showing expected financial impact. The Directors believe that a three-year assessment period for the Viability statement is most appropriate as it aligns with the Group’s well established business planning processes that balance the long-term nature of investments in medicines and vaccines with an assessment of the period over which analysis of near-term business performance is realistically visible.

The Plan has been stress tested in a series of robust operational and principal risk downside scenarios as part of the Board’s review on risk. The Plan assumes the next several years to be challenging for the healthcare industry with continued pressure on pricing of pharmaceuticals. GSK assumes no premature loss of exclusivity for key products over the period and for all anticipated launches to proceed as planned. Despite the ongoing recovery of healthcare systems from the impact of the COVID-19 Pandemic, uncertain economic conditions prevail across many markets in which GSK operates.
The downside scenarios consider GSK’s cash flows, sustainability of dividends, funding strategy, insurance provision and recovery as well as other key financial ratios over the period. These metrics have been subject to sensitivity analysis, which involves flexing a number of the main assumptions underlying the forecasts both individually and in combination, along with mitigating actions that could realistically be taken to avoid or reduce the impact or occurrence of the underlying risk.

The following hypothetical downside scenarios have been evaluated:

Scenario 1: Business performance risks. These include key performance risks, including lower sales from new products, greater adverse impact from generic competition and other competitive launches to other GSK products, as well as possible supply and manufacturing challenges.

Scenario 2: External and macroeconomic risks. This scenario reflects incremental risks to the business driven by outside factors, such as more intense competition, increased pricing pressure in both the US and Europe as well as the potential impact of material negative changes in the macroeconomic and healthcare environment.

Scenario 3: Principal risks. This scenario includes a severe assessment of the potential loss impact from the principal risks related to patient safety, product quality, supply chain continuity and environmental harm as well as anti-bribery and corruption and any consequent regulatory actions, fines or significant litigation, all of which could fundamentally threaten our operations. These risks are managed through mitigating activities described on pages 285 to 295.

Scenario 4: Put option exercise. This scenario evaluates the additional funding requirements assuming the earliest potential exercise of the outstanding put option held by our partner in the HIV business.

The three-year review also makes certain assumptions about the normal level of capital recycling likely to occur and considers whether additional financing facilities will be required and the respective level of funding flexibility and headroom.

The results of this stress testing show that certain combinations of these hypothetical scenarios could increase funding demands on GSK and require mitigating changes to the Group’s funding strategy. However, in light of the liquidity available to the Group and based on this analysis, the Directors have a reasonable expectation that, even under these most severe stress tests, the Group will be able to continue in operation and meet its liabilities as they fall due over the three-year period of assessment.



## Group financial review

<table><tr><td colspan="2">In this section</td></tr><tr><td>Summary full year results</td><td>66</td></tr><tr><td>Financial performance</td><td>68</td></tr><tr><td>Reporting framework</td><td>69</td></tr><tr><td>Adjusting items</td><td>81</td></tr><tr><td>Cash generation and conversion</td><td>86</td></tr><tr><td>Financial position and resources</td><td>87</td></tr><tr><td>Approach to tax</td><td>92</td></tr><tr><td>Treasury policies</td><td>93</td></tr><tr><td>Critical accounting policies</td><td>94</td></tr></table>



## Group financial review

## Summary full year results

<table><tr><td></td><td>Full year 2022 £m</td><td>Growth AER %</td><td>Growth CER %</td><td>Full year 2021(1) £m</td><td>Full year 2020(1) £m</td></tr><tr><td>Turnover</td><td>29,324</td><td>19</td><td>13</td><td>24,696</td><td>24,354</td></tr><tr><td>Total continuing operating profit(1)</td><td>6,433</td><td>48</td><td>31</td><td>4,357</td><td>5,979</td></tr><tr><td>Total EPS(1)</td><td>371.4p</td><td>&gt;100</td><td>&gt;100</td><td>109.6p</td><td>144.4p</td></tr><tr><td>Total continuing EPS(1)</td><td>110.8p</td><td>34</td><td>18</td><td>82.9p</td><td>122.4p</td></tr><tr><td>Total discontinued EPS(1)</td><td>260.6p</td><td>&gt;100</td><td>&gt;100</td><td>26.7p</td><td>22.0p</td></tr><tr><td>Adjusted operating profit(1)</td><td>8,151</td><td>26</td><td>14</td><td>6,493</td><td>6,656</td></tr><tr><td>Adjusted EPS(1)</td><td>139.7p</td><td>27</td><td>15</td><td>110.3p</td><td>114.4p</td></tr><tr><td>Cash generated from operations attributable to continuing operations(1)</td><td>7944</td><td>10</td><td></td><td>7,249</td><td>7,674</td></tr><tr><td>Free cash flow</td><td>3,348</td><td>1</td><td></td><td>3,301</td><td>3,683</td></tr></table>

(1) The amounts presented above for continuing operations and Adjusted results excludes the Consumer Healthcare business discontinued operation. The amounts presented for discontinued EPS are for the demerger of the Consumer Healthcare business. The presentation of continuing and discontinued operations under IFRS 5 are set out on page 192. The 2021 and 2020 comparative results have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see page 238) and the impact of the Share Consolidation implemented on 18 July 2022 (see page 233).

## Total Turnover

Total turnover in 2022 was £29,324 million, up 19% at AER, 13% at CER, reflecting strong performance in all three product groups. Commercial Operations turnover, excluding COVID-19 solution sales, grew 16% at AER, 10% at CER. Specialty Medicines included £2,309 million sales of Xevudy, and double-digit growth across all therapy areas. Vaccines growth reflected strong Shingrix and Meningitis performance, partially offset by pandemic adjuvant sales in 2021. General Medicines reflected the recovery of the antibiotics market and the strong performance of Trelegy in respiratory across all regions.

## Specialty Medicines

Specialty Medicines sales were £11,269 million, up 37% at AER, 29% at CER, driven by consistent double-digit growth in all therapy areas. Specialty Medicines, excluding sales of Xevudy, were £8,960 million up 23% at AER, 15% at CER.

## Vaccines

Vaccines turnover was £7937 million, up 17% at AER, 11% at CER in total, and up 24% at AER, 17% at CER excluding pandemic adjuvant sales. The performance reflected a favourable comparator, which was impacted by COVID-19 related disruptions in several markets primarily in H1 2021, and strong commercial execution of Shingrix, particularly in the US and Europe.

## General Medicines

General Medicines sales in the year were £10,118 million, up 5% at AER, 1% at CER, with the impact of generic competition in US, Europe and Japan offset by Trelegy growth in respiratory and the post-pandemic rebound of the antibiotic market since H2 2021, in Other General Medicines.

## Total Continuing Operating Profit

Total operating profit from continuing operations was £6,433 million compared with £4,357 million in 2021.

This included the £0.9 billion upfront income received from the settlement with Gilead Sciences, Inc. (Gilead), increased profits on turnover growth of 13% at CER and fair value gains on investments, partly offset by higher remeasurement charges for contingent consideration liabilities.

## Total continuing Adjusted operating profit

Adjusted operating profit was £8,151 million, 26% higher at AER and 14% at CER than 2021. The Adjusted operating margin of 27.8% was 1.5 percentage points higher at AER and 0.3 percentage points higher at CER compared to 2021. This primarily reflected the impact from low margin COVID-19 solutions sales (Xevudy). This was offset by operating leverage from strong sales growth, mix benefit, lower inventory adjustments and write-offs and higher royalty income.

## Total Earnings per Share

Total EPS was 371.4p compared with 109.6p in 2021. The increase primarily reflected the profit after taxation for discontinued operations recognised on the Consumer Healthcare business demerger, upfront income received from the settlement with Gilead, increased profits and fair value gains on investments, partly offset by higher remeasurement charges for contingent consideration liabilities and an unfavourable comparison due to a credit of £397 million to Taxation in 2021.



## Group financial review continued

## Total continuing Earnings per Share

Total EPS from continuing operations was 110.8p compared with 82.9p in 2021. This primarily reflected the upfront income received from the settlement with Gilead, increased profits from turnover growth and fair value gains on investments, partly offset by higher remeasurement charges for contingent consideration liabilities and an unfavourable comparison due to a credit of £430 million to Taxation in 2021.

## Total discontinued Earnings per Share

EPS from discontinued operations was 260.6p, compared with 26.7p in 2021. The increase primarily reflected the gain arising on the demerger of Consumer Healthcare recognised in Profit after taxation for discontinued operations.

## Adjusted Earnings per Share

Adjusted EPS was 139.7p compared with 110.3p in 2021. Operating leverage from strong sales growth, beneficial mix and lower inventory adjustments and write-offs, higher royalty income and a lower effective tax rate was partly offset by increased investment behind launches, higher supply chain, freight and distribution costs and higher non-controlling interests.

## Cash generated from operations attributable to continuing operations

Cash generated from operations attributable to continuing operations for the year was £7,944 million (2021: £7,249 million). The increase primarily reflected a significant increase in operating profit, favourable exchange impact and favourable timing of collections, partly offset by unfavourable timing of profit share payments for Xevudy sales, increased cash contributions to the UK defined benefit pension schemes, increased contingent consideration payments and a higher increase in inventory.

## Free cash flow

Free cash inflow from continuing operations was £3,348 million for 2022 (2021: £3,301 million). The increase primarily reflected a significant increase in operating profit, favourable exchange, reduced purchases of intangible assets and favourable timing of collections. This was partly offset by unfavourable timing of profit share payments for Xevudy sales, increased cash contributions to pensions, increased contingent consideration payments, higher tax payments, lower proceeds from disposals, higher capital expenditure and a higher increase in inventory.



## Financial performance

The Total results of the Group are set out below.

<table><tr><td rowspan="2"></td><td colspan="3">2022</td><td colspan="3">2021 \( ^{(1)} \)</td><td rowspan="2">Growth</td></tr><tr><td>£m</td><td>% of turnover</td><td>£m</td><td>% of turnover</td><td>£%</td><td>CER%</td></tr><tr><td>Turnover</td><td>29,324</td><td>100</td><td>24,696</td><td>100</td><td>19</td><td>13</td><td></td></tr><tr><td>Cost of sales</td><td>(9,554)</td><td>(32.6)</td><td>(8,163)</td><td>(33.1)</td><td>17</td><td>16</td><td></td></tr><tr><td>Gross profit</td><td>19,770</td><td>67.4</td><td>16,533</td><td>669</td><td>20</td><td>12</td><td></td></tr><tr><td>Selling, general and administration</td><td>(8,372)</td><td>(28.6)</td><td>(7,070)</td><td>(28.6)</td><td>18</td><td>13</td><td></td></tr><tr><td>Research and development</td><td>(5,488)</td><td>(18.7)</td><td>(5,019)</td><td>(20.3)</td><td>9</td><td>4</td><td></td></tr><tr><td>Royalty income</td><td>758</td><td>2.6</td><td>417</td><td>1.7</td><td>82</td><td>81</td><td></td></tr><tr><td>Other operating (expenses)/income</td><td>(235)</td><td></td><td>(504)</td><td></td><td></td><td></td><td></td></tr><tr><td>Operating profit</td><td>6,433</td><td>219</td><td>4,357</td><td>176</td><td>48</td><td>31</td><td></td></tr><tr><td>Net finance costs</td><td>(803)</td><td></td><td>(755)</td><td></td><td></td><td></td><td></td></tr><tr><td>Loss on disposal of interest in associates</td><td>-</td><td></td><td>(36)</td><td></td><td></td><td></td><td></td></tr><tr><td>Share of after-tax (losses)/profits of associates and joint ventures</td><td>(2)</td><td></td><td>33</td><td></td><td></td><td></td><td></td></tr><tr><td>Profit before taxation</td><td>5,628</td><td></td><td>3,599</td><td></td><td>56</td><td>37</td><td></td></tr><tr><td>Taxation</td><td>(707)</td><td></td><td>(83)</td><td></td><td></td><td></td><td></td></tr><tr><td>Profit after taxation from continuing operations for the year</td><td>4,921</td><td></td><td>3,516</td><td></td><td>40</td><td>23</td><td></td></tr><tr><td>Profit after taxation from discontinued operations and other gains from the demerger</td><td>3,049</td><td></td><td>1,580</td><td></td><td></td><td></td><td></td></tr><tr><td>Remeasurement of discontinued operations distributed to shareholders on demerger</td><td>7,651</td><td></td><td>-</td><td></td><td></td><td></td><td></td></tr><tr><td>Profit after taxation from discontinued operations</td><td>10,700</td><td></td><td>1,580</td><td></td><td>100</td><td>100</td><td></td></tr><tr><td>Total profit after taxation for the year</td><td>15,621</td><td></td><td>5,096</td><td></td><td>100</td><td>100</td><td></td></tr><tr><td>Profit attributable to non-controlling interests from continuing operations</td><td>460</td><td></td><td>200</td><td></td><td></td><td></td><td></td></tr><tr><td>Profit attributable to shareholders from continuing operations</td><td>4,461</td><td></td><td>3,316</td><td></td><td></td><td></td><td></td></tr><tr><td>Profit attributable to non-controlling interests from discontinued operations</td><td>205</td><td></td><td>511</td><td></td><td></td><td></td><td></td></tr><tr><td>Profit attributable to shareholders from discontinued operations</td><td>10,495</td><td></td><td>1,069</td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>15,621</td><td></td><td>5,096</td><td></td><td>100</td><td>100</td><td></td></tr><tr><td>Total profit attributable to non-controlling interests</td><td>665</td><td></td><td>711</td><td></td><td></td><td></td><td></td></tr><tr><td>Total profit attributable to shareholders</td><td>14,956</td><td></td><td>4,385</td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>15,621</td><td></td><td>5,096</td><td></td><td>100</td><td>100</td><td></td></tr><tr><td>Earnings per share from continuing operations (p)</td><td>110.8p</td><td></td><td>829p</td><td></td><td>34</td><td>18</td><td></td></tr><tr><td>Earnings per share from discontinued operations (p)</td><td>260.6p</td><td></td><td>267p</td><td></td><td>100</td><td>100</td><td></td></tr><tr><td>Total earnings per share (p)</td><td>371.4p</td><td></td><td>109.6p</td><td></td><td>100</td><td>100</td><td></td></tr><tr><td>Earnings per ADS from continuing operations (US$)</td><td>2.75</td><td></td><td>2.29</td><td></td><td></td><td></td><td></td></tr><tr><td>Earnings per ADS from discontinued operations (US$)</td><td>6.46</td><td></td><td>0.73</td><td></td><td></td><td></td><td></td></tr><tr><td>Total earnings per ADS (US$)</td><td>9.21</td><td></td><td>3.02</td><td></td><td></td><td></td><td></td></tr></table>

The Adjusted results for the Group are set out below. Reconciliations between Total results and Adjusted results for 2022 and 2021 are set out on pages 81 to 82.

<table><tr><td rowspan="2"></td><td colspan="3">2022</td><td colspan="3">2021 \( ^{(1)} \)</td><td rowspan="2">Growth</td></tr><tr><td>£m</td><td>% of turnover</td><td>£m</td><td>% of turnover</td><td>£%</td><td>CER%</td></tr><tr><td>Turnover</td><td>29,324</td><td>100</td><td>24,696</td><td>100</td><td>19</td><td>13</td><td></td></tr><tr><td>Cost of sales</td><td>(8,741)</td><td>(29.8)</td><td>(7,346)</td><td>(297)</td><td>19</td><td>18</td><td></td></tr><tr><td>Selling, general and administration</td><td>(8,128)</td><td>(27.7)</td><td>(6,749)</td><td>(273)</td><td>20</td><td>15</td><td></td></tr><tr><td>Research and development</td><td>(5,062)</td><td>(17.3)</td><td>(4,525)</td><td>(18.3)</td><td>12</td><td>6</td><td></td></tr><tr><td>Royalty income</td><td>758</td><td>2.6</td><td>417</td><td>1.6</td><td>82</td><td>81</td><td></td></tr><tr><td>Adjusted operating profit</td><td>8,151</td><td>27.8</td><td>6,493</td><td>26.3</td><td>26</td><td>14</td><td></td></tr><tr><td>Adjusted profit attributable to shareholders</td><td>5,625</td><td></td><td>4,415</td><td></td><td>27</td><td>15</td><td></td></tr><tr><td>Adjusted profit attributable to non-controlling interest</td><td>595</td><td></td><td>441</td><td></td><td></td><td></td><td></td></tr><tr><td>Adjusted profit after tax</td><td>6,220</td><td></td><td>4,856</td><td></td><td>28</td><td>16</td><td></td></tr><tr><td>Adjusted earnings per share (p)</td><td>139.7p</td><td></td><td>110.3p</td><td></td><td>27</td><td>15</td><td></td></tr></table>

(1) The 2021 comparative results have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see page 238) and the impact of the Share Consolidation implemented on 18 July 2022 (see page 233).



## Reporting framework

## Total and Adjusted results

The Group financial review discusses the operating and financial performance of the Group, its cash flows and financial position and our resources. The results for each year are compared primarily with the results of the preceding year.

## Total results

Total reported results represent the Group’s overall performance.

GSK also uses a number of adjusted, non-IFRS, measures to report the performance of its business. Adjusted results and other non-IFRS measures may be considered in addition to, but not as a substitute for or superior to, information presented in accordance with IFRS. Adjusted results are defined below and other non-IFRS measures are defined on page 70.

GSK believes that Adjusted results, when considered together with Total results, provide investors, analysts and other stakeholders with helpful complementary information to understand better the financial performance and position of the Group from period to period, and allow the Group's performance to be more easily compared against the majority of its peer companies. These measures are also used by management for planning and reporting purposes. They may not be directly comparable with similarly described measures used by other companies.

GSK encourages investors and analysts not to rely on any single financial measure but to review GSK’s Annual Reports, including the financial statements and notes, in their entirety.

## Adjusted results

Adjusted results exclude the profits from discontinued operations from the Consumer Healthcare business (see details on page 238) and the following items in relation to our continuing operations from Total results, together with the tax effects of all of these items:

– amortisation of intangible assets (excluding computer software and capitalised development costs)

– impairment of intangible assets (excluding computer software) and goodwill

– Major restructuring costs, which include impairments of tangible assets and computer software, (under specific Board approved programmes that are structural, of a significant scale and where the costs of individual or related projects exceed £25 million) including integration costs following material acquisitions

– transaction-related accounting or other adjustments related to significant acquisitions

– proceeds and costs of disposals of associates, products and businesses; significant settlement income; significant legal charges (net of insurance recoveries) and expenses on the settlement of litigation and government investigations; other operating income other than royalty income, and other items
Costs for all other ordinary course smaller scale restructuring and legal charges and expenses are retained within both Total and Adjusted results.

As Adjusted results include the benefits of Major restructuring programmes but exclude significant costs (such as amortisation of intangible assets except for computer software and capitalised development costs, significant legal, major restructuring and transaction items), they should not be regarded as a complete picture of the Group’s financial performance, which is presented in its Total results. The exclusion of other Adjusting items may result in Adjusted earnings being materially higher or lower than Total earnings. In particular, when significant impairments, restructuring charges and legal costs are excluded, Adjusted earnings will be higher than Total earnings.

GSK is undertaking a number of Major restructuring programmes in response to significant changes in the Group’s trading environment or overall strategy, or following material acquisitions. Costs, both cash and non-cash, of these programmes are provided for as individual elements are approved and meet the accounting recognition criteria. As a result, charges may be incurred over a number of years following the initiation of a Major restructuring programme.

Significant legal charges and expenses are those arising from the settlement of litigation or government investigations that are not in the normal course and are materially larger than more regularly occurring individual matters. They also include certain major legacy matters.

Reconciliations between Total and Adjusted results, providing further information on the key Adjusting items for 2022, 2021 and 2020, are set out on pages 81 to 83.

GSK provides earnings guidance to the investor community on the basis of Adjusted results. This is in line with peer companies and expectations of the investor community, supporting easier comparison of the Group’s performance with its peers. GSK is not able to give guidance for Total results as it cannot reliably forecast certain material elements of the Total results, particularly the future fair value movements on contingent consideration and put options that can and have given rise to significant adjustments driven by external factors such as currency and other movements in capital markets.



## Group financial review continued

## Reporting framework continued

## Historical record of Adjusting items

The reconciliations between Total and Adjusted operating profit from continuing operations over the last three years \( ^{(1)} \)  can be summarised as follows:

<table><tr><td></td><td>2022
£m</td><td>2021(2)
£m</td><td>2020(2)
£m</td></tr><tr><td>Total operating profit from continuing operations</td><td>6,433</td><td>4,357</td><td>5,979</td></tr><tr><td>Intangible amortisation</td><td>739</td><td>761</td><td>724</td></tr><tr><td>Intangible impairment</td><td>296</td><td>347</td><td>200</td></tr><tr><td>Major restructuring</td><td>321</td><td>424</td><td>1,178</td></tr><tr><td>Transaction-related items</td><td>1,750</td><td>1,143</td><td>1,237</td></tr><tr><td>Divestments, significant legal and other items</td><td>(1,388)</td><td>(539)</td><td>(2,662)</td></tr><tr><td>Adjusted results</td><td>8,151</td><td>6,493</td><td>6,656</td></tr></table>

The analysis of the impact of transaction-related items on operating profit for each of the last three years is as follows:

<table><tr><td></td><td>2022
£m</td><td>2021(2)
£m</td><td>2020(2)
£m</td></tr><tr><td>Contingent consideration on former Shionogi-ViIV Healthcare JV (including Shionogi preferential dividends)</td><td>1,431</td><td>1,026</td><td>1,114</td></tr><tr><td>ViIV Healthcare put options and Pfizer preferential dividends</td><td>85</td><td>48</td><td>(52)</td></tr><tr><td>Contingent consideration on former Novartis Vaccines business</td><td>193</td><td>27</td><td>172</td></tr><tr><td>Contingent consideration on acquisition of Affinivax</td><td>17</td><td>-</td><td>-</td></tr><tr><td>Other adjustments</td><td>24</td><td>42</td><td>3</td></tr><tr><td>Transaction-related items</td><td>1,750</td><td>1,143</td><td>1,237</td></tr></table>

(1) Three year financial data is presented reflecting the restated results following the demerger of Consumer Healthcare business. The financial results of 2019 and 2018 are not restated and are not presented.

(2) The 2021 and 2020 comparative results have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see page 238).

Full reconciliations between Total and Adjusted results for 2020–2022 including continuing and discontinued operations are set out on pages 81 to 83. Further explanations on the Adjusting items for 2022 are reported on pages 84 to 85.

## Other non-IFRS measures

## Free cash flow

Free cash flow is defined as the net cash inflow/outflow from continuing operating activities less capital expenditure on property, plant and equipment and intangible assets, contingent consideration payments, net finance costs, and dividends paid to non-controlling interests plus proceeds from the sale of property, plant and equipment and intangible assets, and dividends received from joint ventures and associates. It is used by management for planning and reporting purposes and in discussions with and presentations to investment analysts and rating agencies. Free cash flow growth is calculated on a reported basis. A reconciliation of net cash inflow from continuing operating activities to free cash flow is set out on page 86.

## Working capital

Working capital represents inventory and trade receivables less trade payables.

## CER and AER growth

In order to illustrate underlying performance, it is the Group's practice to discuss its results in terms of constant exchange rate (CER) growth. This represents growth calculated as if the exchange rates used to determine the results of overseas companies in Sterling had remained unchanged from those used in the comparative period. CER% represents growth at constant exchange rates. £% or AER% represents growth at actual exchange rates.

## Return on capital employed

Return on capital employed is calculated as total profit before taxation as a percentage of average net assets over the year.

## Total net debt

Net debt is defined as total borrowings less cash, cash equivalents, liquid investments, and short-term loans to third parties that are subject to an insignificant risk of change in value. Please see Note 30 'Net Debt' for the calculation of net debt.

## Total Operating Margin

Total Operating margin is operating profit dividend by turnover.

## Compound Annual Growth Rate (CAGR)

CAGR is defined as the compound annual growth rate and shows the annualised average rate of revenue growth between a number of given years, assuming growth takes place at an exponentially compounded rate.



## Group financial review continued

## Reporting framework continued

## Non-controlling interests in ViiV Healthcare

## Trading profit allocations

As ViiV Healthcare is a subsidiary of the Group, 100% of its operating results (turnover, operating profit, profit after tax) are included within the Group income statement and then a portion of the earnings is allocated to the non-controlling interests owned by the other shareholders, in line with their respective equity shareholdings (Pfizer, Inc. (Pfizer) 11.7% and Shionogi & Co. Ltd (Shionogi) 10%). Each of the shareholders, including GSK, is also entitled to preferential dividends determined by the performance of certain products that each shareholder contributed. As the relative performance of these products changes over time, the proportion of the overall earnings allocated to each shareholder also changes. In particular, the increasing proportion of sales of dolutegravir and cabotegravir-containing products has a favourable impact on the proportion of the preferential dividends that is allocated to GSK. Adjusting items are allocated to shareholders based on their equity interests. GSK was entitled to approximately 83% of the Total earnings and 82% of the Adjusted earnings of ViiV Healthcare for 2022. Remeasurements of the liabilities for the preferential dividends allocated to Pfizer and Shionogi are included within other operating income/(expense).

## Acquisition-related arrangements

As consideration for the acquisition of Shionogi’s interest in the former Shionogi-ViiV Healthcare joint venture in 2012, Shionogi received the 10% equity stake in ViiV Healthcare and ViiV Healthcare also agreed to pay additional future cash consideration to Shionogi, contingent on the future sales performance of the products being developed by that joint venture, dolutegravir and cabotegravir. Under IFRS 3 ‘Business combinations’, GSK was required to provide for the estimated fair value of this contingent consideration at the time of acquisition and is required to update the liability to the latest estimate of fair value at each subsequent period end. The liability for the contingent consideration recognised in the balance sheet at the date of acquisition was £659 million. Subsequent re-measurements are reflected within other operating income/(expense) and within Adjusting items in the income statement in each period.

Cash payments to settle the contingent consideration are made to Shionogi by ViiV Healthcare each quarter, based on the actual sales performance and other income of the relevant products in the previous quarter. These payments reduce the balance sheet liability and hence are not recorded in the income statement. The cash payments made to Shionogi by ViiV Healthcare in 2022 were £1,100 million.

As the liability is required to be recorded at the fair value of estimated future payments, there is a significant timing difference between the charges that are recorded in the Total income statement to reflect movements in the fair value of the liability and the actual cash payments made to settle the liability.
The cash payments are reflected in the cash flow statement partly in operating cash flows and partly within investing activities. The tax relief on these payments is reflected in the Group’s Adjusting items as part of the tax charge. The part of each payment relating to the original estimate of the fair value of the contingent consideration on the acquisition of the Shionogi-ViiV Healthcare joint venture in 2012 of £659 million is reported within investing activities in the cash flow statement and the part of each payment relating to the increase in the liability since the acquisition is reported within operating cash flows.

Movements in contingent consideration payable to Shionogi were as follows:

<table><tr><td></td><td>2022£m</td><td>2021£m</td></tr><tr><td>Contingent consideration at beginning of the year</td><td>5,559</td><td>5,359</td></tr><tr><td>Remeasurement through income statement and other movements</td><td>1,431</td><td>1,026</td></tr><tr><td>Cash payments: operating cash flows</td><td>(1,031)</td><td>(721)</td></tr><tr><td>Cash payments: investing activities</td><td>(69)</td><td>(105)</td></tr><tr><td>Contingent consideration at end of the year</td><td>5,890</td><td>5,559</td></tr></table>

Of the contingent consideration payable (on a post-tax basis) to Shionogi at 31 December 2022, £940 million (31 December 2021: £937 million) is expected to be paid within one year.

## Exit rights

Pfizer may request an IPO of ViiV Healthcare at any time and if either GSK does not consent to such IPO or an offering is not completed within nine months, Pfizer could require GSK to acquire its shareholding. Under the original agreements, GSK had the unconditional right, so long as it made no subsequent distribution to its shareholders, to withhold its consent to the exercise of the Pfizer put option and, as a result, in accordance with IFRS, GSK did not recognise a liability for the put option on its balance sheet. However, during Q1 2016, GSK notified Pfizer that it had irrevocably given up this right and accordingly recognised the liability for the put option on the Group's balance sheet during Q1 2016 at an initial value of £1,070 million. Consistent with this revised treatment, at the end of Q1 2016 GSK also recognised liabilities for the future preferential dividends anticipated to become payable to Pfizer and Shionogi on the Group's balance sheet.

Pfizer has the right to require GSK to acquire its shareholding in ViiV Healthcare in certain circumstances at any time. A put option liability is therefore recorded on the Group’s balance sheet as a current liability. It is measured on the gross redemption basis derived from an internal valuation of the ViiV Healthcare business.

The closing balances of the liabilities related to Pfizer’s shareholding are as follows:

<table><tr><td></td><td>2022£m</td><td>2021£m</td></tr><tr><td>Pfizer put option</td><td>1,093</td><td>1,008</td></tr></table>



## Group financial review continued

## Reporting framework continued

Under the original agreements, Shionogi could also have requested GSK to acquire its shareholding in ViiV Healthcare in six-month windows commencing in 2017, 2020 and 2022. GSK had the unconditional right, so long as it made no subsequent distribution to its shareholders, to withhold its consent to the exercise of the Shionogi put option and, as a result, GSK did not recognise a liability for the put option on its balance sheet.

However, during Q1 2016, GSK notified Shionogi that it had irrevocably given up this right and accordingly recognised the liability for the put option on the Group’s balance sheet during Q1 2016 at an initial value of £926 million. In Q4 2016, Shionogi irrevocably agreed to waive its put option and as a result GSK de-recognised the liability for this put option on the Group’s balance sheet directly to equity. The value of the liability was £1,244 million when it was de-recognised.

GSK also has a call option over Shionogi’s shareholding in ViiV Healthcare, which under the original agreements was exercisable in six-month windows commencing in 2027, 2030 and 2032. GSK has now irrevocably agreed to waive the first two exercise windows, but the last six-month window in 2032 remains. As this call option is at fair value, it has no value for accounting purposes.

## Settlement with Gilead

On 1 February 2022, ViiV Healthcare reached agreement with Gilead to settle the global patent infringement litigation relating to the commercialisation of Gilead's Biktarvy. Under the terms of the global settlement and licensing agreement, Gilead made an upfront payment of $1.25 billion to ViiV Healthcare in February 2022. In addition, Gilead will also pay a 3% royalty on all future US sales of Biktarvy and in respect of the bicegvair component of any other future bicegvair-containing products sold in the US. These royalties will be payable by Gilead to ViiV Healthcare from 1 February 2022 until the expiry of ViiV Healthcare's US Patent No. 8,129,385 on 5 October 2027. Gilead's obligation to pay royalties does not extend into any period of regulatory paediatric exclusivity, if awarded.

The impact of the settlement with Gilead on the contingent consideration liability (CCL) was to increase it by £288 million, on a post-tax basis in Q4 2021 due to the obligation ViiV Healthcare has to pay future cash consideration to Shionogi for its share of the upfront and of the future US sales performance of Biktarvy and products containing bicegvair. The liability which is discounted at 8% is £5,890 million at 31 December 2022 on a post-tax basis. The impact of the settlement on the Pfizer put option liability was an increase of £114 million and was included in the re-measurement at 31 December 2021.

## Reporting definitions

## COVID-19 solutions

COVID-19 solutions include the sales of pandemic adjuvant and other COVID-19 solutions including vaccine manufacturing and Xevudy and the associated costs but does not include reinvestment in R&D. This categorisation is used by management and we believe is helpful to investors by providing clarity on the results of the Group by showing the contribution to growth from COVID-19 solutions.

## General Medicines

General medicines are usually prescribed in the primary care or community settings by general healthcare practitioners. For GSK, this includes medicines in inhaled respiratory, dermatology, antibiotics and other diseases.

## Specialty Medicines

Specialty medicines are typically prescription medicines used to treat complex or rare chronic conditions. For GSK, this comprises medicines in infectious diseases, HIV, oncology, immunology and respiratory.

## Share Consolidation

Shareholders received 4 new Ordinary shares with a nominal value of 31 \( ^{1} \) /4 pence each for every 5 existing Ordinary shares which had a nominal value of 25 pence each. Earnings per share, diluted earnings per share, adjusted earnings per share and dividends per share were retrospectively adjusted to reflect the Share Consolidation in all the periods presented.

## Earnings per share

Earnings per share has been retrospectively adjusted for the Share Consolidation on 18 July 2022, applying a ratio of 4 new Ordinary shares for every 5 existing Ordinary shares.

## Total Earnings per share

Unless otherwise stated, Total earnings per share refers to Total basic earnings per share. The same principle applies to continuing and discontinued earnings per share.



## Financial performance

## Group turnover

## Group turnover by business



● Specialty Medicines

£11.3bn

AER growth 37% CER growth 29%

Vaccines

£7.9bn

AER growth 17% CER growth 11%

● General Medicines

£10.1bn

AER growth 5% CER growth 1%

## Group turnover by geographic region



US

£14.5bn

AER growth 22% CER growth 10%

Europe

£6.3bn

AER growth 18% CER growth 19%

International

£8.4bn

AER growth 14% CER growth 14%

## Group turnover

GSK has revised its operating segments during the year. Previously, GSK reported results under four segments: Pharmaceuticals; Pharmaceuticals R&D; Vaccines and Consumer Healthcare. GSK now reports results under two segments namely Commercial Operations and Total R&D. See Note 6 to the consolidated financial statements for more details.

The Commercial Operations segment has three product groups of Specialty Medicines, Vaccines and General Medicines.

• Specialty Medicines products which includes GSK’s marketed products for HIV, oncology, immuno-inflammatory, respiratory and other specialty medicines (including Nucala) and the pandemic solution, Xevudy;

• Vaccines products, including sales of GSK’s AS03 adjuvant as part of the pandemic solutions;

• General Medicines products, which include products previously reported as Established Pharmaceuticals and sales of Trelegy Ellipta and Anoro Ellipta (previously reported within the Respiratory category under Specialty products). These products are typically accessed by patients through primary care settings.

Group turnover was £29,324 million in the year, up 19% at AER, 13% at CER. In 2022 sales grew 16% at AER, 10% CER excluding COVID-19 solutions.

## Specialty medicines

## Turnover (£bn)

£11.3bn
38% of Group turnover
AER growth
37%

2020

7.0

2021

2022

8.3

2022

11.3

## Specialty medicines turnover



● Specialty turnover excluding COVID-19 solutions

£9.0bn
AER growth 23% CER growth 15%

Pandemic turnover

£2.3bn
AER growth  \( \geq $ 100% CER growth  \( \geq $ 100%

<table><tr><td></td><td>2022 £m</td><td>2021 (revised) £m</td><td>Growth £%</td><td>Growth CER%</td></tr><tr><td>HIV</td><td>5,749</td><td>4,777</td><td>20</td><td>12</td></tr><tr><td>Oncology</td><td>602</td><td>489</td><td>23</td><td>17</td></tr><tr><td>Immuno-inflammation, respiratory and other</td><td>2,609</td><td>2,027</td><td>29</td><td>20</td></tr><tr><td></td><td>8,960</td><td>7,293</td><td>23</td><td>15</td></tr><tr><td>Pandemic</td><td>2,309</td><td>958</td><td>&gt;100</td><td>&gt;100</td></tr><tr><td>Specialty medicines</td><td>11,269</td><td>8,251</td><td>37</td><td>29</td></tr></table>

2021 has been revised to reflect changes to product groups previously reported as Established Pharmaceuticals.

## HIV

HIV sales were £5,749 million with growth of 20% at AER, 12% at CER. The performance benefited from strong patient demand for the new HIV medicines (Dovato, Cabenva, Juluca, Rukobia and Apretude), which contributed approximately three quarters of the growth. US pricing favourability and year-end inventory build together contributed one third of the growth which was partially offset by International tender decline.

New HIV products delivered sales of over two billion to £2,474 million, up 78% at AER, 67% at CER, representing 43% of the total HIV portfolio compared to 29% last year. Growth was primarily driven by sales of Dovato and Cabenva. Dovato recorded sales of £1,375 million up 75% at AER and 65% at CER and Cabenva, the first long acting injectable for the treatment of HIV-1 infection, recorded sales of £340 million. Apretude, the first long acting injectable for the prevention of HIV-1 delivered sales of £41 million.



## Group financial review continued

## Financial performance continued

## Oncology

Oncology sales were £602 million, up 23% at AER, 17% at CER. Zejula sales of £463 million were up 17% at AER, 12% at CER driven by the first line indication, but with diagnosis and treatment rates continuing to be impacted by the pandemic especially in the US. Sales of Blenrep of £118 million grew 33% at AER, 25% at CER, and included the impact of withdrawal from US market in Q4 2022.

## Immuno-inflammation, respiratory and other

Immuno-inflammation, Respiratory and Other sales were £2,609 million up 29% at AER, 20% at CER on strong performance of Benlysta and Nucala. Benlysta sales were £1,146 million, up 31% at AER, 20% at CER, representing strong underlying demand in US and worldwide. Nucala sales were £1,423 million, up 25% at AER, 18% at CER, reflecting continued strong patient demand and the launch of additional indications.

## Pandemic

Sales of Xevudy were £2,309 million, compared to £958 million sales in 2021. Sales were delivered in all regions, comprising £828 million in the US, £456 million in Europe, and £1,025 million in International.

## Vaccines

Turnover (£bn)

£7.9bn

27% of Group turnover

AER growth
17%
CER growth
11%



## Vaccines turnover



● Vaccines turnover excluding COVID-19 solutions

£7.9bn

AER growth 24% CER growth 17%

Pandemic turnover

£64 million
AER decline -86% CER decline -86%

<table><tr><td></td><td>2022 £m</td><td>2021 £m</td><td>Growth £%</td><td>Growth CER%</td></tr><tr><td>Meningitis</td><td>1,116</td><td>961</td><td>16</td><td>11</td></tr><tr><td>Influenza</td><td>714</td><td>679</td><td>5</td><td>(4)</td></tr><tr><td>Shingles</td><td>2,958</td><td>1,721</td><td>72</td><td>60</td></tr><tr><td>Established Vaccines</td><td>3,085</td><td>2,970</td><td>4</td><td>—</td></tr><tr><td></td><td>7,873</td><td>6,331</td><td>24</td><td>17</td></tr><tr><td>Pandemic Vaccines</td><td>64</td><td>447</td><td>(86)</td><td>(86)</td></tr><tr><td>Vaccines</td><td>7937</td><td>6,778</td><td>17</td><td>11</td></tr></table>

## Meningitis

Meningitis vaccines sales grew 16% at AER, 11% at CER to £1,116 million mainly driven by Bexsero up 16% at AER, 12% at CER to £753 million resulting from higher CDC (Center for Disease Control) demand and increased share in the US. Menveo sales were also up 27% AER, 18% CER to £345 million, primarily driven by post-pandemic vaccination catch-up and higher public demand in International, together with favourable pricing mix and share gain in the US.

## Influenza

Fluarix/FluLaval sales grew by 5% AER but decreased 4% CER to £714 million, primarily driven by lower post-pandemic demand in Europe and the US, partly offset by lower expected returns in the US.



## Group financial review continued

## Financial performance continued

## Shingles

Shingrix sales grew 72% at AER, 60% at CER to £2,958 million. All regions grew significantly reflecting post-pandemic rebound, strong uptake and new market launches with more than half of the growth contributed from outside of the US. In the US, Shingrix grew 46% at AER, 32% at CER to £1,964 million due to higher non-retail and retail demand and strong commercial execution. Germany and China contributed strongly to the Shingrix growth. Shingrix was launched in 9 markets during 2022 and is now available in 26 countries.

## Established Vaccines

Established Vaccines grew 4% AER but were stable at CER to £3,085 million mainly resulting from supply constraints in MMR/V vaccines and lower tender demand in International for Synflorix. This was offset by hepatitis vaccines demand rebound in the US and Europe and Boostrix post-pandemic demand recovery and increased share in the US.

## Pandemic Vaccines

Pandemic Vaccines decreased 86% AER and CER primarily reflecting comparison to 2021 pandemic adjuvant sales to the US and Canadian governments partly offset by GSK’s share of 2022 contracted European volumes related to the COVID-19 booster vaccine developed through a collaboration with Sanofi Pasteur (Sanofi).

## General Medicines

## Turnover (£bn)

<table><tr><td>£10.1bn</td><td>AER growth 5%</td><td>CER growth 1%</td></tr><tr><td colspan="3">35% of Group turnover</td></tr><tr><td>2020</td><td></td><td>10.4</td></tr><tr><td>2021</td><td></td><td>9.7</td></tr><tr><td>2022</td><td></td><td>10.1</td></tr></table>

## General Medicines turnover

<table><tr><td></td><td>2022 £m</td><td>2021 (revised) £m</td><td>Growth £%</td><td>Growth CER%</td></tr><tr><td>Respiratory</td><td>6,548</td><td>6,048</td><td>8</td><td>3</td></tr><tr><td>Other general medicines</td><td>3,570</td><td>3,619</td><td>(1)</td><td>(2)</td></tr><tr><td>General medicines</td><td>10,118</td><td>9,667</td><td>5</td><td>1</td></tr></table>

2021 has been revised to reflect changes to product groups previously reported as Established Pharmaceuticals.

## Respiratory

Respiratory sales were £6,548 million, up 8% at AER, 3% at CER. The performance was driven by Trelegy sales of £1,729 million, up 42% AER, 32% CER, including strong growth across all regions. Advair/Seretide sales of £1,159 million decreased 15% at AER, 17% at CER predominantly reflecting the adverse impact of generic competition, with growth in certain International markets due to targeted promotion offsetting the decrease.

## Other general medicines

Other General Medicines sales were £3,570 million, decreasing 1% at AER, 2% at CER. Augmentin sales were £576 million, up 35% at AER, 38% at CER, reflecting the post pandemic rebound of the antibiotic market since H2 2021 in the International and Europe regions. This partially offsets the ongoing adverse impact of generic competition, and approximately two percentage points impact at AER and CER from the divestment of cephalosporin products in Q4 2021.



## Group financial review continued

## Financial performance continued

## Turnover by regions

## US

In the US, sales were £14,542 million, up 22% at AER, 10% at CER. Sales adjusted for COVID-19 solutions were up 24% AER, 12% CER. Sales of Xevudy were £828 million.

In Specialty, HIV sales of £3,756 million were up 30% at AER, 17% at CER. Growth benefited from strong patient demand for all new HIV products, pricing favourability and year-end inventory build. New HIV medicines (Dovato, Cabenuva, Juluca, Rukobia and Apretude) sales were £1,685 million up 88% at AER, 70% at CER. Nucala in respiratory and Benlysta in immunology both continued to grow double-digit and reflected ongoing strong patient demand. Oncology sales increased 14% at AER, 3% at CER with diagnosis and treatment rates continuing to be impacted by the pandemic for Zejula, and the withdrawal of Blenrep from the US market in Q4 2022.

Vaccine sales were £4,243 million, up 22% at AER, 10% at CER, excluding the impact of pandemic adjuvant sales in 2021, sales increased 31% at AER, 18% at CER. The performance was primarily driven by Shingrix sales of £1,964 million up 46% at AER, 32% at CER, mostly due to higher non-retail and retail demand and strong commercial execution. Demand recovery in Established Vaccines and share gains in Meningitis vaccines also contributed to growth.

General Medicines sales were £3,572 million up 10% at AER down 1% at CER. Trelegy was up 47% at AER, 32% at CER reflecting increased patient demand and growth of the single inhaler triple therapy market, and Flovent grew on launch of authorised generics in the year. Overall, there was a three-percentage point reduction in growth of US General Medicines due to prior period Returns and Rebates (RAR) adjustments in the year.

## Europe

In Europe, sales were £6,348 million, up 18% at AER, 19% at CER, including COVID-19 solution sales of £513 million contributing 8 percentage points of growth at AER and CER.

In Specialty Medicines, HIV sales were £1,310 million up 10% at AER, 10% at CER primarily driven by strong patient demand for Dovato, Cabenuva and Juluca. Dovato delivered sales of £478 million, Juluca £127 million and Cabenuva £40 million. Benlysta in immunology, Nucala in respiratory, and Oncology medicines Zejula, Blenrep and Jemperli all continued to show strong double-digit growth.

Vaccine sales were £1,884 million, up 31% at AER, 32% at CER. The performance was driven by Shingrix sales of £688 million, >100% at AER and CER, particularly in Germany. Pandemic adjuvant sales of £57 million contributed four percentage points of growth at AER and CER.
General Medicines sales of £2,079 million decreased 3% at AER and CER, reflecting the ongoing impact of generic competitive pressures on Seretide and the divestment in Q4 2021 of cephalosporin products which caused one percentage point of drag on growth at AER and CER. This was partly offset, however, by strong demand for Trelegy and the growth of Augmentin following the post-pandemic rebound of the antibiotic market since H2 2021.

## International

International sales were £8,434 million, up 14% at AER and CER, including Xevudy sales of £1,025 million. Sales grew 7% AER and 6% CER excluding sales of COVID-19 solutions.

In Specialty, HIV sales were £683 million, stable at AER and decreased 3% at CER, primarily driven by tender decline. Excluding tenders, International grew driven by strong Dovato growth. Combined Tivicay and Triumeg sales were £506 million, down 12% at AER and 15% at CER. Nucala sales of £242 million grew 24% at AER and 28% at CER reflecting strong market growth and patient uptake. Benlysta sales of £114 million grew 44% at AER, 43% at CER reflecting growth in the biological market in Japan and inclusion on China's National Reimbursement Drug List.

Vaccine sales were £1,810 million, down 3% at AER, 5% at CER, reflecting an 11 percentage points drag at AER and CER from COVID-19 vaccine adjuvant sales in 2021. Growth excluding COVID-19 solutions was driven by strong Shingrix take-up in China, Canada and Japan more than offsetting the impact of supply constraints in MMR/V vaccines and lower Synflorix tender demand across several markets.

General Medicines sales were £4,467 million up 5% at AER and CER. Respiratory sales of £1,955 million increased 10% at AER, 9% at CER, with Trelegy sales up 47% at AER, 48% at CER reflecting strong demand and inclusion on China's National Reimbursement Drug List. Sales of Advair/Seretide were up 3% at AER, 1% at CER with the adverse impact of generic competition offset by growth in certain markets due to targeted promotion. Other General Medicines sales of £2,512 million increased 1% at AER, 2% at CER, and reflected growth of Augmentin following the post-pandemic rebound of the antibiotic market since H2 2021, partially offset by generic competition and price reductions in certain markets.



## Group financial review continued

## Financial performance continued

## Cost of sales

<table><tr><td></td><td>2022£m</td><td>2021(1)£m</td><td>Growth£%</td><td>GrowthCER%</td></tr><tr><td>Total cost of sales</td><td>(9,554)</td><td>(8,163)</td><td>17</td><td>16</td></tr><tr><td>Adjusted cost of sales</td><td>(8,741)</td><td>(7,346)</td><td>19</td><td>18</td></tr></table>

(1) The 2021 comparative results have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see page 238).

Total cost of sales as a percentage of turnover was 32.6%, 0.5 percentage points lower at AER and 0.9 percentage points higher in CER terms than 2021.

Adjusted cost of sales as a percentage of turnover was 29.8%, 0.1 percentage points higher at AER and 1.3 percentage points higher at CER compared with 2021. This primarily reflected higher sales of lower margin Xevudy compared to 2021 which included higher margin pandemic adjuvant sales, increasing cost of sales margin by 2.5 percentage points at AER and CER, as well as the impact of increased commodity prices and freight costs. This was partially offset by a favourable mix primarily from increased sales of Shingrix in the US and Europe and increased sales of HIV medicines in the US, lower inventory adjustments and write offs in Vaccines and continued contribution from restructuring savings.

## Selling, general and administration

<table><tr><td></td><td>2022£m</td><td>2021(1)£m</td><td>Growth£%</td><td>GrowthCER%</td></tr><tr><td>Total selling, general and administration</td><td>(8,372)</td><td>(7,070)</td><td>18</td><td>13</td></tr><tr><td>Adjusted selling, general and administration</td><td>(8,128)</td><td>(6,749)</td><td>20</td><td>15</td></tr></table>

(1) The 2021 comparative results have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see page 238).

Total SG&A costs as a percentage of turnover were 28.6%, 0.1 percentage points lower at AER and stable at CER compared to 2021. This included a reduction in restructuring charges.

Adjusted SG&A costs as a percentage of turnover were 27.7%, 0.4 percentage points higher at AER and 0.5 percentage points higher at CER than in 2021. Adjusted SG&A costs increased 20% at AER, 15% at CER which primarily reflected an increased level of launch investment in Specialty Medicines particularly HIV and Vaccines including Shingrix to drive post-pandemic recovery demand and support market expansion. The growth in Adjusted SG&A also reflected an unfavourable comparison to a beneficial legal settlement in 2021 as well as impairment provisions relating to Russia and Ukraine. This growth was partly offset by the continuing benefit of restructuring and tight control of ongoing costs.

## Research and development

<table><tr><td></td><td>2022£m</td><td>2021(1)£m</td><td>Growth£%</td><td>GrowthCER%</td></tr><tr><td>Total research and development</td><td>(5,488)</td><td>(5,019)</td><td>9</td><td>4</td></tr><tr><td>Adjusted research and development</td><td>(5,062)</td><td>(4,525)</td><td>12</td><td>6</td></tr></table>

(1) The 2021 comparative results have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see page 238).

Total R&D expenditure was £5,488 million up 9% at AER, 4% at CER. This included amortisation and impairments.

Adjusted R&D expenditure in the full-year increased by 12% at AER, and 6% at CER, to £5,062 million. This reflected continued increased investment across Vaccines clinical development, including investments into our mRNA technology platforms, continued investment in the late-stage portfolio and several early discovery programmes, as well as expenditure related to our recent acquisition of Affinivax, Inc (Affinivax).

In addition, in Specialty Medicines, the level of R&D investment increased to support the phase III respiratory programme for depemokimab, a potential new medicine to treat severe asthma, and bepiovirus, our study in chronic hepatitis B, in preparation for the start of the phase III trial. In Oncology, investment increased in our early-stage immuno-oncology assets and in mometolinib (MMB), our potential new treatment of myelofibrosis patients with anaemia, acquired as part of the recent Sierra Oncology acquisition. These increases in investment were offset by decreases related to the completion of several late-stage clinical development programmes and reduced R&D investment in COVID-19 pandemic solutions versus 2021.

## Royalty income

Royalty income was £758 million (2021: £417 million), up 82% at AER, 81% at CER, the increase primarily reflecting royalty income from Gilead under the settlement and licensing agreement with Gilead announced on 1 February 2022 and Gardasil royalty income increasing to £446 million due to higher sales.



## Group financial review continued

## Financial performance continued

## Other operating income/(expense)

Net other operating expense was £235 million (2021: £504 million) reflecting accounting charges of £1,726 million (2021: £1,101 million) arising from the remeasurement of contingent consideration liabilities and the liabilities for the Pfizer put option and Pfizer and Shionogi preferential dividends in ViiV Healthcare. This included a remeasurement charge of £1,431 million (2021: £1,026 million) for the contingent consideration liability due to Shionogi, including the unwinding of the discount of £410 million and a charge for £1,021 million primarily from changes to exchange rates as well as adjustments to sales forecasts. This was partly offset by £922 million upfront income received from the settlement with Gilead, fair value gain on investments including £229 million on the retained stake in Haleon plc (Haleon), reflecting an increase in share price since listing and milestone income from disposals.

## Operating profit

Total operating profit from continuing operations was £6,433 million compared with £4,357 million in 2021.

This included the £922 million upfront income received from the settlement with Gilead, increased profits on turnover growth of 19% at AER, 13% at CER and fair value gains on investments including £229 million on the retained stake in Haleon, partly offset by higher remeasurement charges for contingent consideration liabilities. Adjusted operating profit was £8,151 million, 26% higher at AER and 14% at CER than 2021 on a turnover increase of 13% at CER. The Adjusted operating margin of 27.8% was 1.5 percentage points higher at AER and 0.3 percentage points higher at CER compared to 2021. This primarily reflected the impact from low margin COVID-19 solutions sales (Xevudy), which reduced Adjusted Operating profit growth by 3% AER and CER and reduced the Adjusted operating margin by approximately 1.4 percentage points at AER and approximately 1.3 percentage points at CER. This was offset by operating leverage from strong sales growth, mix benefit, lower inventory adjustments and write offs and higher royalty income.

Contingent consideration cash payments made to Shionogi and other companies reduce the balance sheet liability and hence are not recorded in the income statement. Total contingent consideration cash payments in 2022 amounted to £1,137 million (2021: £856 million). These included cash payments made to Shionogi of £1,100 million (2021: £826 million).

## Adjusted operating profit by business

Commercial Operations operating profit was £13,590 million, up 19% at AER and 10% at CER on a turnover increase of 13% at CER. The operating margin of 46.3% was 0.1 percentage points lower at AER, 1.2 percentage points lower at CER than in 2021. This primarily reflected strong sales of lower margin Xevudy, increased investment behind launches in Specialty Medicines including HIV and Vaccines plus higher commodity, freight and distribution costs as well as an adverse comparison to a favourable legal settlement in 2021. This was partly offset by leverage from strong sales growth, mix and lower inventory adjustments and write-offs, continued tight control of ongoing costs, benefits from continued restructuring and increased royalty income from Biktarvy and Gardasil sales.

R&D segment operating expenses were £5,060 million, up 11% at AER, 5% at CER, primarily reflecting increased investment in Vaccines including priority investments for mRNA, late stage portfolio and expenditure from the acquisition of Affinivax and in Specialty Medicines in early stage HIV and depemokimab. This was partly offset by decreases related to the completion of several late-stage clinical development programmes and reduced R&D investment in COVID-19 pandemic solutions versus 2021.



## Group financial review continued

## Financial performance continued

## Net finance costs

<table><tr><td>Finance income</td><td>2022£m</td><td>2021(1)£m</td></tr><tr><td>Interest and other income</td><td>62</td><td>13</td></tr><tr><td>Fair value movements</td><td>14</td><td>1</td></tr><tr><td></td><td>76</td><td>14</td></tr><tr><td>Finance expense</td><td></td><td></td></tr><tr><td>Interest expense</td><td>(789)</td><td>(735)</td></tr><tr><td>Unwinding of discounts on provisions</td><td>(7)</td><td>(2)</td></tr><tr><td>Remeasurements and fair value movements</td><td>(20)</td><td>(2)</td></tr><tr><td>Finance expense on lease liabilities</td><td>(30)</td><td>(27)</td></tr><tr><td>Other finance expense</td><td>(33)</td><td>(3)</td></tr><tr><td></td><td>(879)</td><td>(769)</td></tr></table>

(1) The 2021 comparative results have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see page 238).

Total net finance costs were £803 million compared with £755 million in 2021. Adjusted net finance costs were £791 million compared with £752 million in 2021. The increase is mainly driven by costs associated with the Sterling Notes repurchase in Q4 2022 and higher interest on tax offset by increased interest income due to higher interest rates and larger cash balances as a result of the Consumer Healthcare demerger.

## Share of after tax profits of associates and joint ventures

The share of after tax loss of associates and joint ventures was £2 million (2021: £33 million share of profit).

## Loss on disposal of interest in associates

In 2021, the Group also reported a net loss on disposal of interests in associates of £36 million, primarily driven by a loss on disposal of our interest in the associate Innoviva Inc.

## Profit before tax

Taking account of net finance costs, the share of profits of associates and loss on disposal of interest in associates, profit before taxation was £5,628 million compared with £3,599 million in 2021.

## Taxation

<table><tr><td></td><td>2022£m</td><td>2021(1)£m</td></tr><tr><td>UK current year charge</td><td>200</td><td>119</td></tr><tr><td>Rest of world current year charge</td><td>1,351</td><td>593</td></tr><tr><td>Charge/(credit) in respect of prior periods</td><td>(60)</td><td>219</td></tr><tr><td>Total current taxation</td><td>1,491</td><td>931</td></tr><tr><td>Total deferred taxation</td><td>(784)</td><td>(848)</td></tr><tr><td>Taxation on total profits</td><td>707</td><td>83</td></tr></table>

(1) The 2021 comparative results have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see page 238).

The charge of £707 million represented an effective tax rate on Total results of 12.6% (2021: 2.3%) and reflected the different tax effects of the various Adjusting items. Included in 2021 was a credit of £430 million resulting from the remeasurement of deferred tax assets following enactment of the proposed change of UK corporate income tax rates from 19% to 25%. Tax on Adjusted profit amounted to £1,138 million and represented an effective Adjusted tax rate of 15.5% (2021: 15.9%).

Issues related to taxation are described in Note 14 to the financial statements 'Taxation'. The Group continues to believe it has made adequate provision for the liabilities likely to arise from periods which are open and not yet agreed by tax authorities. The ultimate liability for such matters may vary from the amounts provided and is dependent upon the outcome of agreements with relevant tax authorities.

## Non-controlling interests

The allocation of Total profit from continuing operations to non-controlling interests amounted to £460 million (2021: £200 million). The increase was primarily due to an increased allocation of ViV Healthcare profits of £416 million (2021: £197 million), including the Gilead upfront settlement income, partly offset by increased credits for remeasurement of contingent consideration liabilities, as well as higher net profits in some of the Group’s other entities with non-controlling interests.

The allocation of Adjusted earnings from continuing operations to non-controlling interests amounted to £595 million (2021: £441 million). The increase in allocation primarily reflected an increased allocation of ViV Healthcare profits of £551 million (2021: £438 million), as well as higher net profits in some of the Group’s other entities with non-controlling interests.

## Earnings per share from continuing operations

Total EPS from continuing operations was 110.8p compared with 82.9p in 2021. This primarily reflected the £922 million upfront income received from the settlement with Gilead, increased profits on turnover growth of 13% at CER and fair value gains on investments including the retained stake in Haleon, partly offset by higher remeasurement charges for contingent consideration liabilities and an unfavourable comparison due to a credit of £430 million to Taxation in 2021 resulting from the remeasurement of deferred tax assets.

Adjusted EPS was 139.7p compared with 110.3p in 2021, up 27% at AER, 15% at CER on a 13% CER turnover increase. Operating leverage from growth in sales of Specialty Medicines including HIV and Vaccines, beneficial mix and lower inventory adjustments and write-offs, higher royalty income and a lower effective tax rate was partly offset by increased investment behind launches in Specialty Medicines including HIV and Vaccines plus higher supply chain costs, freight and distribution costs and higher non-controlling interests. Growth in lower margin COVID-19 solutions sales reduced Adjusted EPS growth by 4% AER and 3% CER.



## Group financial review continued

## Financial performance continued

## Profit and earnings per share from discontinued operations

Discontinued operations include the Consumer Healthcare business and certain Corporate costs directly attributable to the Consumer Healthcare business. Profit after taxation from discontinued operations amounted to £10,700 million (2021: £1,580 million). This includes £10,084 million for the gain arising on the demerger of Consumer Healthcare split between the amount distributed to shareholders on demerger of £7,651 million and profit after taxation on discontinued operations for the retained stake of £2,433 million. In addition, the Profit after taxation from discontinued operations for the Consumer Healthcare business was £616 million (2021: £1,580 million).

EPS from discontinued operations was 260.6p, compared with 26.7p in 2021. The increase primarily reflected the gain arising on the demerger of the Consumer Healthcare business. For further details see page 238.

## Total earnings per share

Total EPS was 371.4p compared with 109.6p in 2021. The increase primarily reflected the profit after taxation for discontinued operations recognised on the Consumer Healthcare business demerger, upfront income received from the settlement with Gilead, increased profits and fair value gains on investments, partly offset by higher remeasurement charges for contingent consideration liabilities and an unfavourable comparison due to a credit of £397 million to Taxation in 2021.

## Dividends

The Board has declared four interim dividends resulting in a total dividend for the year of 61.25p per share retrospectively adjusted for the share consolidation. The 2021 dividend per share was 100p retrospectively adjusted for the share consolidation. See Note 16 to the financial statements, 'Dividends'.

## Dividend policy

On 23 June 2021, at the new GSK Investor Update, GSK set out that from 2022 a progressive dividend policy will be implemented guided by a 40 to 60 percent pay-out ratio through the investment cycle. The dividend policy, the total expected cash distribution, and the respective dividend pay-out ratios for GSK remain unchanged.

GSK has previously stated that it expected to declare a 27p per share dividend for the first half of 2022, a 22p per share dividend for the second half of 2022 and a 45p per share dividend for 2023 (before the Share Consolidation) but that these targeted dividends per share would increase in step with the Share Consolidation to maintain the same aggregate dividend pay-out in absolute Sterling terms. Accordingly, using the consolidation ratio, GSK's expected dividend for the fourth quarter of 2022 converts to 13.75p per new ordinary share. This results in an expected total dividend for the second half of 2022 of 27.5p per new ordinary share. The expected dividend for 2023 converts to 56.5p per new ordinary share in line with the original expectation converted for the Share Consolidation and rounded up.

## Guidance and Outlook

GSK expects 2023 turnover to increase between 6 to 8 per cent, Adjusted operating profit to increase between 10 to 12 per cent and Adjusted earnings per share to increase between 12 to 15 per cent. This guidance is provided at CER and excludes any contributions from COVID-19 solutions.

In outlining the guidance for 2023, the Group has made certain assumptions about the healthcare sector, the different markets in which the Group operates and the delivery of revenues and financial benefits from its current portfolio, pipeline and restructuring programmes. Due to the phasing of quarterly results in 2022 and the resulting comparators, GSK expects turnover and Adjusted operating profit growth to be slightly lower in the first half of 2023 including a challenging comparator in Q1 2022 and somewhat higher in the second half, relative to full-year expectations. Despite the ongoing recovery of healthcare systems from the impact of the COVID-19 pandemic, uncertain economic conditions prevail across many markets in which GSK operates and we continue to expect to see variability in performance between quarters.

We expect sales of Specialty Medicines to increase mid to high single-digit per cent, sales of Vaccines to increase mid-teens per cent and sales of General Medicines to decrease slightly.

## COVID-19 solutions

Based on known binding agreements with governments, GSK does not anticipate any significant COVID-19 pandemic-related sales or operating profit in 2023. Sales of COVID-19 solutions were £2.4 billion in 2022 and therefore we expect a reduction in Turnover growth by approximately 9% and a reduction in Adjusted Operating profit growth by 6% to 7%. However, the Company continues to discuss future opportunities to support governments, healthcare systems, and patients whereby its COVID-19 solutions can address the emergence of any new COVID-19 variant of concern.



## Adjusting items

<table><tr><td colspan="3">Adjusted results reconciliation 31 December 2022</td><td>Total results £m</td><td>Profit from discount-in-timed operation £m</td><td>Intangible asset amortisation £m</td><td>Intangible asset impairment £m</td><td>Major restructuring £m</td><td>Transaction-related £m</td><td>Divestments, significant legal and other items £m</td><td>Adjusted results £m</td></tr><tr><td>Turnover</td><td></td><td>29,324</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>29,324</td></tr><tr><td>Cost of sales</td><td></td><td>(9,554)</td><td></td><td></td><td>648</td><td></td><td>102</td><td>45</td><td>18</td><td>(8,741)</td></tr><tr><td>Gross profit</td><td></td><td>19,770</td><td></td><td></td><td>648</td><td></td><td>102</td><td>45</td><td>18</td><td>20,583</td></tr><tr><td>Selling, general and administration</td><td></td><td>(8,372)</td><td></td><td></td><td></td><td></td><td>180</td><td>13</td><td>51</td><td>(8,128)</td></tr><tr><td>Research and development</td><td></td><td>(5,488)</td><td></td><td></td><td>91</td><td>296</td><td>39</td><td></td><td></td><td>(5,062)</td></tr><tr><td>Royalty income</td><td></td><td>758</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>758</td></tr><tr><td>Other operating (expense)/income</td><td></td><td>(235)</td><td></td><td></td><td></td><td></td><td></td><td>1692</td><td>(1,457)</td><td>-</td></tr><tr><td>Operating profit</td><td></td><td>6,433</td><td></td><td>739</td><td>296</td><td>321</td><td>1750</td><td>(1,358)</td><td>8,151</td><td></td></tr><tr><td>Net finance costs</td><td></td><td>(803)</td><td></td><td></td><td></td><td>2</td><td></td><td>10</td><td>(791)</td><td></td></tr><tr><td>Share of after-tax losses of associates and joint ventures</td><td></td><td>(2)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>(2)</td></tr><tr><td>Profit before taxation</td><td></td><td>5,628</td><td></td><td>739</td><td>296</td><td>323</td><td>1750</td><td>(1,378)</td><td>7,358</td><td></td></tr><tr><td>Taxation</td><td></td><td>(707)</td><td></td><td>(150)</td><td>(64)</td><td>(87)</td><td>(242)</td><td>112</td><td>(1,138)</td><td></td></tr><tr><td>Tax rate</td><td></td><td>12.6%</td><td></td><td></td><td></td><td></td><td></td><td></td><td>15.5%</td><td></td></tr><tr><td>Profit after taxation from continuing operations</td><td></td><td>4,921</td><td></td><td>589</td><td>232</td><td>236</td><td>1,508</td><td>(1,266)</td><td>6,220</td><td></td></tr><tr><td>Profit after taxation from discontinued operations and other gains/(losses) from the demerger</td><td></td><td>3,049</td><td>(3,049)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Remeasurement of discontinued operations distributed to shareholders on demerger</td><td></td><td>7,651</td><td>(7,651)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Profit after taxation from discontinued operations</td><td></td><td>10,700</td><td>(10,700)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Total profit after taxation for the year</td><td></td><td>15,621</td><td>(10,700)</td><td>589</td><td>232</td><td>236</td><td>1,508</td><td>(1,266)</td><td>6,220</td><td></td></tr><tr><td>Profit attributable to non-controlling interests from continuing operations</td><td></td><td>460</td><td></td><td></td><td></td><td></td><td>135</td><td></td><td>595</td><td></td></tr><tr><td>Profit attributable to shareholders from continuing operations</td><td></td><td>4,461</td><td></td><td>589</td><td>232</td><td>236</td><td>1,373</td><td>(1,266)</td><td>5,625</td><td></td></tr><tr><td>Profit attributable to non-controlling interest from discontinued operations</td><td></td><td>205</td><td>(205)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Profit attributable to shareholders from discontinued operations</td><td></td><td>10,495</td><td>(10,495)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td>15,621</td><td>(10,700)</td><td>589</td><td>232</td><td>236</td><td>1,508</td><td>(1,266)</td><td>6,220</td><td></td></tr><tr><td>Total profit attributable to non-controlling interests</td><td></td><td>665</td><td>(205)</td><td></td><td></td><td></td><td>135</td><td></td><td>595</td><td></td></tr><tr><td>Total profit attributable to shareholders</td><td></td><td>14,956</td><td>(10,495)</td><td>589</td><td>232</td><td>236</td><td>1,373</td><td>(1,266)</td><td>5,625</td><td></td></tr><tr><td></td><td></td><td>15,621</td><td>(10,700)</td><td>589</td><td>232</td><td>236</td><td>1,508</td><td>(1,266)</td><td>6,220</td><td></td></tr><tr><td>Earnings per share from continuing operations</td><td></td><td>110.8p</td><td></td><td>14.6p</td><td>5.8p</td><td>5.9p</td><td>34.1p</td><td>(31.5)p</td><td>139.7p</td><td></td></tr><tr><td>Earnings per share from discontinued operations</td><td></td><td>260.6p</td><td>(260.6)p</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Total earnings per share</td><td></td><td>371.4p</td><td>(260.6)p</td><td>14.6p</td><td>5.8p</td><td>5.9p</td><td>34.1p</td><td>(31.5)p</td><td>139.7p</td><td></td></tr><tr><td>Weighted average number of shares (millions)</td><td></td><td>4,026</td><td></td><td></td><td></td><td></td><td></td><td></td><td>4,026</td><td></td></tr></table>



## Group financial review continued

## Financial performance continued

<table><tr><td colspan="3">Adjusted results reconciliation 31 December 2021(1)</td><td>Total results £m</td><td>Profit from discontinued operations £m</td><td>Intangible asset amortisation £m</td><td>Intangible asset impairment £m</td><td>Major restructuring £m</td><td>Transaction-related £m</td><td>Divestments, significant legal and other items £m</td><td>Adjusted results £m</td></tr><tr><td>Turnover</td><td>24,696</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>24,696</td></tr><tr><td>Cost of sales</td><td>(8,163)</td><td></td><td></td><td>660</td><td></td><td>102</td><td>28</td><td>27</td><td>(7,346)</td><td></td></tr><tr><td>Gross profit</td><td>16,533</td><td></td><td></td><td>660</td><td></td><td>102</td><td>28</td><td>27</td><td>17,350</td><td></td></tr><tr><td>Selling, general and administration</td><td>(7,070)</td><td></td><td></td><td></td><td></td><td>277</td><td>9</td><td>35</td><td>(6,749)</td><td></td></tr><tr><td>Research and development</td><td>(5,019)</td><td></td><td></td><td>101</td><td>347</td><td>45</td><td></td><td>1</td><td>(4,525)</td><td></td></tr><tr><td>Royalty income</td><td>417</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>417</td><td></td></tr><tr><td>Other operating (expense)/income</td><td>(504)</td><td></td><td></td><td></td><td></td><td></td><td>1106</td><td>(602)</td><td></td><td></td></tr><tr><td>Operating profit</td><td>4,357</td><td></td><td></td><td>761</td><td>347</td><td>424</td><td>1143</td><td>(539)</td><td>6,493</td><td></td></tr><tr><td>Net finance costs</td><td>(755)</td><td></td><td></td><td></td><td></td><td>2</td><td></td><td>1</td><td>(752)</td><td></td></tr><tr><td>Loss on disposal of interest in associates</td><td>(36)</td><td></td><td></td><td></td><td></td><td></td><td></td><td>36</td><td>-</td><td></td></tr><tr><td>Share of after-tax profits of associates and joint ventures</td><td>33</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>33</td><td></td></tr><tr><td>Profit before taxation</td><td>3,599</td><td></td><td></td><td>761</td><td>347</td><td>426</td><td>1143</td><td>(502)</td><td>5,774</td><td></td></tr><tr><td>Taxation</td><td>(83)</td><td></td><td></td><td>(153)</td><td>(81)</td><td>(79)</td><td>(179)</td><td>(343)</td><td>(918)</td><td></td></tr><tr><td>Tax rate</td><td>2.3%</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>15.9%</td><td></td></tr><tr><td>Profit after taxation from continuing operations</td><td>3,516</td><td></td><td></td><td>608</td><td>266</td><td>347</td><td>964</td><td>(845)</td><td>4,856</td><td></td></tr><tr><td>Profit after taxation from discontinued operations and other gains/(losses) from the demerger</td><td>1,580</td><td>(1,580)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Profit after taxation from discontinued operations</td><td>1,580</td><td>(1,580)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Total profit after taxation for the year</td><td>5,096</td><td>(1,580)</td><td>608</td><td>266</td><td>347</td><td>964</td><td>(845)</td><td>4,856</td><td></td><td></td></tr><tr><td>Profit attributable to non-controlling interests from continuing operations</td><td>200</td><td></td><td></td><td></td><td></td><td></td><td>241</td><td></td><td>441</td><td></td></tr><tr><td>Profit attributable to shareholders from continuing operations</td><td>3,316</td><td></td><td></td><td>608</td><td>266</td><td>347</td><td>723</td><td>(845)</td><td>4,415</td><td></td></tr><tr><td>Profit attributable to non-controlling interest from discontinued operations</td><td>511</td><td>(511)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Profit attributable to shareholders from discontinued operations</td><td>1,069</td><td>(1,069)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>5,096</td><td>(1,580)</td><td>608</td><td>266</td><td>347</td><td>964</td><td>(845)</td><td>4,856</td><td></td><td></td></tr><tr><td>Total profit attributable to non-controlling interests</td><td>711</td><td>(511)</td><td></td><td></td><td></td><td></td><td>241</td><td></td><td>441</td><td></td></tr><tr><td>Total profit attributable to shareholders</td><td>4,385</td><td>(1,069)</td><td>608</td><td>266</td><td>347</td><td>723</td><td>(845)</td><td>4,415</td><td></td><td></td></tr><tr><td></td><td>5,096</td><td>(1,580)</td><td>608</td><td>266</td><td>347</td><td>964</td><td>(845)</td><td>4,856</td><td></td><td></td></tr><tr><td>Earnings per share from continuing operations</td><td>829p</td><td></td><td></td><td>15.2p</td><td>6.6p</td><td>8.7p</td><td>18.1p</td><td>(21.2)p</td><td>110.3p</td><td></td></tr><tr><td>Earnings per share from discontinued operations</td><td>267p</td><td>(26.7)p</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Total earnings per share</td><td>109.6p</td><td>(26.7)p</td><td>15.2p</td><td>6.6p</td><td>8.7p</td><td>18.1p</td><td>(21.2)p</td><td>110.3p</td><td></td><td></td></tr><tr><td>Weighted average number of shares (millions)</td><td>4,003</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>4,003</td><td></td></tr></table>

(1) The 2021 comparative results have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see page 238) and the impact of Share Consolidation implemented on 18 July 2022 (see page 233).



## Group financial review continued

Financial performance continued

<table><tr><td colspan="3">Adjusted results reconciliation 31 December 2020(1)</td><td>Total results £m</td><td>Profit from discontinued unlisted operations £m</td><td>Intangible asset amortisation £m</td><td>Intangible asset impairment £m</td><td>Major restructuring £m</td><td>Transaction-related £m</td><td>Divestments, significant legal and other items £m</td><td>Adjusted results £m</td></tr><tr><td>Turnover</td><td>24,354</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>24,354</td></tr><tr><td>Cost of sales</td><td>(7,929)</td><td></td><td></td><td>649</td><td>-</td><td>585</td><td>23</td><td>-</td><td>(6,672)</td><td></td></tr><tr><td>Gross profit</td><td>16,425</td><td></td><td></td><td>649</td><td>-</td><td>585</td><td>23</td><td>-</td><td>17,682</td><td></td></tr><tr><td>Selling, general and administration</td><td>(7,437)</td><td></td><td></td><td></td><td>2</td><td>395</td><td>(1)</td><td>16</td><td>(7,025)</td><td></td></tr><tr><td>Research and development</td><td>(4,793)</td><td></td><td></td><td>75</td><td>198</td><td>198</td><td></td><td></td><td>(4,322)</td><td></td></tr><tr><td>Royalty income</td><td>321</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>321</td><td></td></tr><tr><td>Other operating (expense)/income</td><td>1,463</td><td></td><td></td><td></td><td></td><td></td><td>1,215</td><td>(2,678)</td><td>-</td><td></td></tr><tr><td>Operating profit</td><td>5,979</td><td></td><td></td><td>724</td><td>200</td><td>1,178</td><td>1,237</td><td>(2,662)</td><td>6,656</td><td></td></tr><tr><td>Net finance costs</td><td>(842)</td><td></td><td></td><td></td><td></td><td>2</td><td></td><td>2</td><td>(838)</td><td></td></tr><tr><td>Share of after-tax profits of associates and joint ventures</td><td>33</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>33</td><td></td></tr><tr><td>Profit before taxation</td><td>5,170</td><td></td><td></td><td>724</td><td>200</td><td>1,180</td><td>1,237</td><td>(2,660)</td><td>5,851</td><td></td></tr><tr><td>Taxation</td><td>(67)</td><td></td><td></td><td>(142)</td><td>(38)</td><td>(213)</td><td>(231)</td><td>(125)</td><td>(816)</td><td></td></tr><tr><td>Tax rate</td><td>1.3%</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>13.9%</td><td></td></tr><tr><td>Profit after taxation from continuing operations</td><td>5,103</td><td></td><td></td><td>582</td><td>162</td><td>967</td><td>1,006</td><td>(2,785)</td><td>5,035</td><td></td></tr><tr><td>Profit after taxation from discontinued operations and other gains/(losses) from the demerger</td><td>1,285</td><td>(1,285)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Profit after taxation from discontinued operations</td><td>1,285</td><td>(1,285)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Total profit after taxation for the year</td><td>6,388</td><td>(1,285)</td><td></td><td>582</td><td>162</td><td>967</td><td>1,006</td><td>(2,785)</td><td>5,035</td><td></td></tr><tr><td>Profit attributable to non-controlling interests from continuing operations</td><td>230</td><td></td><td></td><td></td><td></td><td></td><td>251</td><td></td><td>481</td><td></td></tr><tr><td>Profit attributable to shareholders from continuing operations</td><td>4,873</td><td></td><td></td><td>582</td><td>162</td><td>967</td><td>755</td><td>(2,785)</td><td>4,554</td><td></td></tr><tr><td>Profit attributable to non-controlling interest from discontinued operations</td><td>409</td><td>(409)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Profit attributable to shareholders from discontinued operations</td><td>876</td><td>(876)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>6,388</td><td>(1,285)</td><td></td><td>582</td><td>162</td><td>967</td><td>1,006</td><td>(2,785)</td><td>5,035</td><td></td></tr><tr><td>Total profit attributable to non-controlling interests</td><td>639</td><td>(409)</td><td></td><td></td><td></td><td></td><td>251</td><td></td><td>481</td><td></td></tr><tr><td>Total profit attributable to shareholders</td><td>5,749</td><td>(876)</td><td></td><td>582</td><td>162</td><td>967</td><td>755</td><td>(2,785)</td><td>4,554</td><td></td></tr><tr><td></td><td>6,388</td><td>(1,285)</td><td></td><td>582</td><td>162</td><td>967</td><td>1,006</td><td>(2,785)</td><td>5,035</td><td></td></tr><tr><td>Earnings per share from continuing operations</td><td>122.4p</td><td></td><td></td><td>14.6p</td><td>41p</td><td>24.3p</td><td>19.0p</td><td>(70.0)p</td><td>114.4p</td><td></td></tr><tr><td>Earnings per share from discontinued operations</td><td>22.0p</td><td>(22.0p)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Total earnings per share</td><td>144.4p</td><td>(22.0p)</td><td></td><td>14.6p</td><td>41p</td><td>24.3p</td><td>19.0p</td><td>(70.0)p</td><td>114.4p</td><td></td></tr><tr><td>Weighted average number of shares (millions)</td><td>3,981</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>3,981</td><td></td></tr></table>

(1) The 2020 comparative results have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see page 238) and the impact of Share Consolidation implemented on 18 July 2022 (see page 233).



## Group financial review continued

## Adjusting items continued

## Profit from discontinued operations

Discontinued operations include the Consumer Healthcare business and certain Corporate costs directly attributable to the Consumer Healthcare business. Profit after taxation from discontinued operations amounted to £10,700 million (2021: £1,580 million). This includes £10,084 million for the gain arising on the demerger of Consumer Healthcare split between the amount distributed to shareholders on demerger of £7,651 million and profit after taxation on discontinued operations for the retained stake of £2,433 million. In addition, the Profit after taxation from discontinued operations for the Consumer Healthcare business was £616 million (2021: £1,580 million).

## Intangible asset amortisation

See page 211 for description and information on Intangible asset amortisation.

## Intangible asset impairment

See page 211 for description and information on Intangible asset impairment. No individual intangible asset accounted for a material impairment.

## Major restructuring and integration

Within the Pharmaceuticals sector, the highly regulated manufacturing operations and supply chains and long life cycle of the business mean that restructuring programmes, particularly those that involve the rationalisation or closure of manufacturing or R&D sites are likely to take several years to complete.

Major restructuring costs are those related to specific Board-approved Major restructuring programmes and are excluded from Adjusted results. Major restructuring programmes, including integration costs following material acquisitions, are those that are structural and are of a significant scale where the costs of individual or related projects exceed £25 million. Other ordinary course smaller-scale restructuring costs are retained within Total and Adjusted results.

Total Major restructuring charges incurred in 2022 were £321 million (2021 \( ^{[0]} $ : £424 million), analysed as follows:

<table><tr><td></td><td colspan="4">2022</td><td colspan="4">2021 \( ^{[0]} \)</td></tr><tr><td></td><td>Cash £m</td><td>Non-cash £m</td><td>Total £m</td><td>Cash £m</td><td>Non-cash £m</td><td>Total £m</td><td></td><td></td></tr><tr><td>Separation preparation restructuring programme</td><td>177</td><td>110</td><td>287</td><td>353</td><td>59</td><td>412</td><td></td><td></td></tr><tr><td>Significant acquisitions</td><td>20</td><td>-</td><td>20</td><td>-</td><td>-</td><td>-</td><td></td><td></td></tr><tr><td>Legacy programmes</td><td>9</td><td>5</td><td>14</td><td>32</td><td>(20)</td><td>12</td><td></td><td></td></tr><tr><td></td><td>206</td><td>115</td><td>321</td><td>385</td><td>39</td><td>424</td><td></td><td></td></tr></table>

(1) The 2021 comparative results have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see page 238).

Cash charges of £177 million under the Separation Preparation programme primarily arose from the restructuring of some administrative functions as well as Global Supply Chain, R&D functions and commercial. The non-cash charges of £110 million primarily reflected the write-down of assets in administrative and manufacturing locations and impairment of IT assets.

Total cash payments made in 2022 were £388 million (2021: £551 million), £332 million (2021: £428 million) relating to the Separation Preparation restructuring programme, £17 million relating to significant acquisitions (2021: £nil) and £39 million (2021: £123 million) relating to other legacy programmes including the settlement of certain charges accrued in previous quarters.

The analysis of Major restructuring charges by income statement line was as follows:

<table><tr><td></td><td>2022</td><td>2021 \( ^{(1)} \)</td></tr><tr><td></td><td>£m</td><td>£m</td></tr><tr><td>Cost of sales</td><td>102</td><td>102</td></tr><tr><td>Selling, general and administration</td><td>180</td><td>277</td></tr><tr><td>Research and development</td><td>39</td><td>45</td></tr><tr><td>Total Major restructuring costs from continuing operations</td><td>321</td><td>424</td></tr></table>

(1) The 2021 comparative results have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see page 238).

The benefit in 2022 from restructuring programmes was £0.5 billion, primarily relating to the Separation Preparation restructuring programme.

The Group initiated in Q1 2020 a Separation Preparation programme to prepare for the separation of GSK into two companies: The programme aims were:

– Drive a common approach to R&D with improved capital allocation

– Align and improve the capabilities and efficiency of global support functions to support GSK

– Further optimise the supply chain and product portfolio, including the divestment of non-core assets

– Prepare Consumer Healthcare to operate as a standalone company

The programme delivered £0.9 billion of annual savings by 2022 and targets to deliver £1.0 billion by 2023, with total costs estimated at £2.4 billion, of which £1.6 billion is expected to be cash costs. The proceeds of divestments have largely covered the cash costs of the programme.



## Group financial review continued

## Adjusting items continued

## Transaction-related adjustments

Transaction-related adjustments from continuing operations resulted in a net charge of £1,750 million (2021: £1,143 million). This included a net £1,726 million accounting charge for the re-measurement of the contingent consideration liabilities and the liabilities for the Pfizer put option and Pfizer and Shionogi preferential dividends in ViiV Healthcare.

<table><tr><td>Charge/(credit)</td><td>2022 £m</td><td>2021(1) £m</td></tr><tr><td>Contingent consideration on former Shionogi-ViiV Healthcare Joint Venture (including Shionogi preferential dividends)</td><td>1,431</td><td>1,026</td></tr><tr><td>ViiV Healthcare put options and Pfizer preferential dividends</td><td>85</td><td>48</td></tr><tr><td>Contingent consideration on former Novartis Vaccines business</td><td>193</td><td>27</td></tr><tr><td>Contingent consideration on acquisition of Affinivax</td><td>17</td><td>-</td></tr><tr><td>Other adjustments</td><td>24</td><td>42</td></tr><tr><td>Total transaction-related charges</td><td>1,750</td><td>1,143</td></tr></table>

(1) The 2021 comparative results have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see page 238).

The £1,431 million charge relating to the contingent consideration for the former Shionogi-ViiV Healthcare joint venture represented an increase in the valuation of the contingent consideration due to Shionogi, as a result of the unwind of the discount for £410 million and a charge of £1,021 million primarily from adjustments to sales forecasts and the settlement with Gilead as well as updated exchange rate assumptions. The £85 million charge relating to the ViiV Healthcare put option and Pfizer preferential dividends represented an increase in the valuation of the put option as a result of the settlement with Gilead, offset by lower cash and updated exchange rate assumptions.
The ViiV Healthcare contingent consideration liability is fair valued under IFRS. An explanation of the accounting for the non-controlling interests in ViiV Healthcare is set out on page 71.

## Divestments, significant legal charges and other items

Divestments, significant legal charges and other items primarily included the £922 million upfront settlement income received from Gilead, a fair value gain on investments including £229 million on the retained stake in Haleon as well as milestone income and gains from a number of asset disposals, partly offset by certain other Adjusting items.

## Discontinued operations

From Q2 2020, the Group started to report additional costs to prepare for establishment of the Consumer Healthcare business as an independent entity (“Separation costs”). These are presented as part of discontinued operations. Total separation costs incurred in 2022 were £366 million (2021: £314 million). This includes £103 million relating to transaction costs incurred in connection with the demerger and preparatory admission costs related to the listing of Haleon.

Total separation costs to date are £748 million including £141 million relating to transaction costs.



## Cash generation and conversion

A summary of the consolidated cash flow statement is set out below.

<table><tr><td></td><td>2022
£m</td><td>2021
£m</td></tr><tr><td>Total net cash inflow from operating activities</td><td>7,403</td><td>7,952</td></tr><tr><td>Total net cash (outflow) from investing activities</td><td>(8,772)</td><td>(1,777)</td></tr><tr><td>Total net cash inflow/(outflow) from financing activities</td><td>823</td><td>(7,589)</td></tr><tr><td>Decrease in cash and bank overdrafts</td><td>(546)</td><td>(1,414)</td></tr><tr><td>Cash and bank overdrafts at beginning of year</td><td>3,819</td><td>5,262</td></tr><tr><td>Exchange adjustments</td><td>152</td><td>(29)</td></tr><tr><td>Decrease in cash and bank overdrafts</td><td>(546)</td><td>(1,414)</td></tr><tr><td>Cash and bank overdrafts at end of year</td><td>3,425</td><td>3,819</td></tr><tr><td>Cash and bank overdrafts at end of year comprise:</td><td></td><td></td></tr><tr><td>Cash and cash equivalents</td><td>3,723</td><td>4,274</td></tr><tr><td>Overdrafts</td><td>(298)</td><td>(455)</td></tr><tr><td></td><td>3,425</td><td>3,819</td></tr></table>

## Reconciliation of net cash inflow from continuing operating activities to free cash inflow

A reconciliation of net cash inflow from operating activities, which is the closest equivalent IFRS measure to free cash flow, is shown below.

<table><tr><td></td><td>2022
£m</td><td>2021(1)
£m</td></tr><tr><td>Net cash inflow from continuing operating activities</td><td>6,634</td><td>6,277</td></tr><tr><td>Purchase of property, plant and equipment</td><td>(1,143)</td><td>(950)</td></tr><tr><td>Purchase of intangible assets</td><td>(1,115)</td><td>(1,704)</td></tr><tr><td>Proceeds from sale of property, plant and equipment</td><td>146</td><td>132</td></tr><tr><td>Proceeds from sale of intangible assets</td><td>196</td><td>641</td></tr><tr><td>Net finance costs</td><td>(784)</td><td>(758)</td></tr><tr><td>Dividends from joint ventures and associates</td><td>6</td><td>9</td></tr><tr><td>Contingent consideration paid (reported in investing activities)</td><td>(79)</td><td>(114)</td></tr><tr><td>Contribution from non-controlling interests</td><td>8</td><td>7</td></tr><tr><td>Distributions to non-controlling interests</td><td>(521)</td><td>(239)</td></tr><tr><td>Free cash inflow</td><td>3,348</td><td>3,301</td></tr></table>

(1) The 2021 comparative results have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see page 238).

## Capital expenditure and financial investment

Cash payments for tangible and intangible fixed assets amounted to £2,258 million (2021: £2,654 million) and disposals realised £342 million (2021: £773 million). Cash payments to acquire equity investments amounted to £143 million (2021: £162 million) and sales of equity investments realised £238 million (2021: £202 million).

## Free cash flow

Free cash flow is the amount of cash generated by the Group after meeting our obligations for contingent consideration, interest, tax and dividends paid to non-controlling interests, and after capital expenditure on property, plant and equipment and intangible assets.

<table><tr><td></td><td>2022
£m</td><td>2021(1)
£m</td></tr><tr><td>Free cash inflow</td><td>3,348</td><td>3,301</td></tr></table>

(1) The 2021 comparative results have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see page 238).

Total cash payments to Shionogi in relation to the ViiV Healthcare contingent consideration liability in the year were £1,100 million (2021: £826 million), of which £1,031 million was recognised in cash flows from operating activities and £69 million was recognised in contingent consideration paid within investing cash flows. These payments are deductible for tax purposes.

## Future cash flow

Over the long term, we expect that future cash generated from operations will be sufficient to fund our operating and debt servicing costs, normal levels of capital expenditure, obligations under existing licensing agreements, expenditure arising from restructuring programmes and other routine outflows including tax, pension contributions and dividends, subject to the 'Principal risks and uncertainties' discussed on pages 285 to 295. We may from time to time have additional demands for finance, such as for acquisitions. We have access to multiple sources of liquidity from short and long-term capital markets and financial institutions for such needs, in addition to the cash flow from operations.

## Investment appraisal and capital allocation

We have a strong framework for capital allocation, including a board to govern the allocation of capital between our businesses. We utilise a consistent cash return on invested capital (CROIC) methodology to prioritise investment across the Group as a whole, so that we can more effectively compare the returns from each of the businesses as we allocate capital between them. We also consider the impact on EPS and our credit profile where relevant.



## Financial position and resources

<table><tr><td></td><td>2022
£m</td><td>2021
£m</td></tr><tr><td>Assets</td><td></td><td></td></tr><tr><td>Non-current assets</td><td></td><td></td></tr><tr><td>Property, plant and equipment</td><td>8,933</td><td>9,932</td></tr><tr><td>Right of use assets</td><td>687</td><td>740</td></tr><tr><td>Goodwill</td><td>7,046</td><td>10,552</td></tr><tr><td>Other intangible assets</td><td>14,318</td><td>30,079</td></tr><tr><td>Investments in associates and joint ventures</td><td>74</td><td>88</td></tr><tr><td>Other investments</td><td>1,467</td><td>2,126</td></tr><tr><td>Deferred tax assets</td><td>5,658</td><td>5,218</td></tr><tr><td>Derivative financial instruments</td><td>-</td><td>18</td></tr><tr><td>Other non-current assets</td><td>1,194</td><td>1,676</td></tr><tr><td>Total non-current assets</td><td>39,377</td><td>60,429</td></tr><tr><td>Current assets</td><td></td><td></td></tr><tr><td>Inventories</td><td>5,146</td><td>5,783</td></tr><tr><td>Current tax recoverable</td><td>405</td><td>486</td></tr><tr><td>Trade and other receivables</td><td>7,053</td><td>7,860</td></tr><tr><td>Derivative financial instruments</td><td>190</td><td>188</td></tr><tr><td>Current equity investments</td><td>4,087</td><td>-</td></tr><tr><td>Liquid investments</td><td>67</td><td>61</td></tr><tr><td>Cash and cash equivalents</td><td>3,723</td><td>4,274</td></tr><tr><td>Assets held for sale</td><td>98</td><td>22</td></tr><tr><td>Total current assets</td><td>20,769</td><td>18,674</td></tr><tr><td>Total assets</td><td>60,146</td><td>79,103</td></tr><tr><td>Liabilities</td><td></td><td></td></tr><tr><td>Current liabilities</td><td></td><td></td></tr><tr><td>Short-term borrowings</td><td>(3,952)</td><td>(3,601)</td></tr><tr><td>Contingent consideration liabilities</td><td>(1,289)</td><td>(958)</td></tr><tr><td>Trade and other payables</td><td>(16,263)</td><td>(17,554)</td></tr><tr><td>Derivative financial instruments</td><td>(183)</td><td>(227)</td></tr><tr><td>Current tax payable</td><td>(471)</td><td>(489)</td></tr><tr><td>Short-term provisions</td><td>(652)</td><td>(841)</td></tr><tr><td>Total current liabilities</td><td>(22,810)</td><td>(23,670)</td></tr><tr><td>Non-current liabilities</td><td></td><td></td></tr><tr><td>Long-term borrowings</td><td>(17,035)</td><td>(20,572)</td></tr><tr><td>Corporation tax payable</td><td>(127)</td><td>(180)</td></tr><tr><td>Deferred tax liabilities</td><td>(289)</td><td>(3,556)</td></tr><tr><td>Pensions and other post-employment benefits</td><td>(2,579)</td><td>(3,113)</td></tr><tr><td>Other provisions</td><td>(532)</td><td>(630)</td></tr><tr><td>Derivative financial instruments</td><td>-</td><td>(1)</td></tr><tr><td>Contingent consideration liabilities</td><td>(5,779)</td><td>(5,118)</td></tr><tr><td>Other non-current liabilities</td><td>(899)</td><td>(921)</td></tr><tr><td>Total non-current liabilities</td><td>(27,240)</td><td>(34,091)</td></tr><tr><td>Total liabilities</td><td>(50,050)</td><td>(57,761)</td></tr><tr><td>Net assets</td><td>10,096</td><td>21,342</td></tr><tr><td>Total equity</td><td>10,096</td><td>21,342</td></tr></table>

## Property, plant and equipment

Our business is science-based, technology-intensive and highly regulated by governmental authorities. We allocate significant financial resources to the renewal and maintenance of our property, plant, equipment and vehicles to minimise risks of interruption to production and to ensure compliance with regulatory standards. A number of our processes use hazardous materials.

The total cost of our property, plant and equipment at 31 December 2022 was £19,451 million, with a net book value of £8,933 million. Of this, land and buildings represented £3,113 million, plant, equipment and vehicles £4,012 million and assets in construction £1,808 million. In 2022, we invested £1,245 million in new property, plant and equipment. This was mainly related to a large number of projects for the renewal, improvement and expansion of facilities at various worldwide sites to support new product development and launches as well as to improve the efficiency of existing supply chains. Property is mainly held freehold. New investment is financed from our liquid resources. At 31 December 2022, we had contractual commitments for future capital expenditure of £743 million. We believe that our property and plant facilities are adequate for our current requirements.

## Right of use assets

Right of use assets amounted to £687 million at 31 December 2022 compared with £740 million at 31 December 2021. The decrease in the year reflected the impact of depreciation and transfer to assets held for sale/distribution of £192 million and £127 million respectively, disposals and impairments amounting to £75 million, partly offset by additions through business combinations of £53 million and other additions of £233 million.

## Goodwill

Goodwill decreased to £7,046 million at 31 December 2022, from £10,552 million primarily as a result of transfer of assets held for sale/distribution of £5,183 million for the Consumer Healthcare demerger partially offset by an increase of £1,127 million for the acquisitions of Sierra Oncology and Affinivax.

## Other intangible assets

Other intangible assets include the cost of intangibles acquired from third parties and computer software. The net book value of other intangible assets as at 31 December 2022 was £14,318 million (2021: £30,079 million). The decrease primarily reflected transfer to assets held for sale/distribution of £19,957 million, impairment losses, net of reversals and amortisation of £1,519 million, offset by additions, net of disposals, write-offs of £4,047 million and exchange rate gains of £1,628 million.



## Group financial review continued

## Financial position and resources continued

## Investments in associates and joint ventures

We held investments in associates and joint ventures with a carrying value at 31 December 2022 of £74 million (2021: £88 million). See Note 21 to the financial statements, 'Investments in associates and joint ventures' for more details.

## Current equity investments

Current equity investments amounted to £4,087 million at 31 December 2022 (2021: £nil). Current equity investments comprise equity investments which the Group holds with the intention to sell and which it may sell in the short term. Where acquired with this intention, they are measured at fair value through the profit and loss (FVTPL). They are initially recorded at fair value plus transaction costs and then remeasured at subsequent reporting dates to fair value. Unrealised gains and losses are recognised in the income statement. The investment of £4,087 million (2021: £nil) represents the shares held in Haleon after the demerger.

## Other investments

We held other investments with a carrying value at 31 December 2022 of £1,467 million (2021: £2,126 million). The most significant of these investments held at 31 December 2022 were in Vir Biotechnology and Nimbus Discovery. These investments had a fair value at 31 December 2022 of £180 million (2021: £266 million) and £139 million (2021: £32 million) respectively. The other investments included equity stakes in companies with which we have research collaborations, and which provide access to biotechnology developments of potential interest and interests in companies that arise from business divestments.

## Derivative financial instruments: assets

We held current derivative financial assets at fair value of £190 million (2021: £188 million) and non-current derivative financial assets held at fair value of £nil (2021: £18 million). The majority of these financial instruments related to foreign exchange contracts both designated and not designated as accounting hedges.

## Inventories

Inventories amounted to £5,146 million (2021: £5,783) at 31 December 2022. The decrease was mainly driven by the Consumer Healthcare demerger partially offset by vaccines stock build.

## Trade and other receivables

Trade and other receivables amounted to £7,053 million (2021: £7,860 million) at 31 December 2022. The decrease was mainly driven by the Consumer Healthcare demerger and lower pandemic adjuvant sales compared to last year.

## Deferred tax assets

Deferred tax assets amounted to £5,658 million (2021: £5,218 million) at 31 December 2022.

## Derivative financial instruments: liabilities

We held current and non-current derivative financial liabilities at fair value of £183 million (2021: £228 million). This primarily related to foreign exchange contracts both designated and not designated as accounting hedges.

## Trade and other payables

At 31 December 2022, trade and other payables were £16,263 million compared with £17,554 million at 31 December 2021. See Note 29 to the financial statements, 'Trade and other payables'. The decrease was mainly driven by the Consumer Healthcare demerger and profit share collaborations offset by an increase in promotional activity in the regions.

## Provisions

We carried deferred tax provisions and other short-term and non-current provisions of £1,473 million at 31 December 2022 (2021: £5,027 million). Other provisions at the year-end included £218 million (2021: £196 million) related to legal and other disputes and £351 million (2021: £652 million) related to Major restructuring programmes. Provision has been made for legal and other disputes, indemnified disposal liabilities, employee related liabilities and the costs of the restructuring programme to the extent that at the balance sheet date a legal or constructive obligation existed and could be reliably estimated.

## Pensions and other post-employment benefits

We account for pension and other post-employment arrangements in accordance with IAS 19. The net deficits were £1,356 million (2021: £1,129 million) on pension arrangements and £994 million (2021: £1,243 million) on unfunded post-employment liabilities. See Note 31 to the financial statements, 'Pensions and other post-employment benefits'.

## Other non-current liabilities

Other non-current liabilities amounted to £899 million at 31 December 2022 (2021: £921 million).

## Contingent consideration liabilities

Contingent consideration amounted to £7,068 million at 31 December 2022 (2021: £6,076 million), of which £5,890 million (2021: £5,559 million) represented the estimated present value of amounts payable to Shionogi relating to ViiV Healthcare, £501 million (2021: £nil) represented the estimated present value of contingent consideration payable to the former shareholders of Affinivax and £673 million (2021: £479 million) represented the estimated present value of contingent consideration payable to Novartis related to the Vaccines acquisition.

The liability due to Shionogi was £263 million in respect of preferential dividends. An explanation of the accounting for the non-controlling interests in ViiV Healthcare is set out on page 71.

Of the total contingent consideration payable (on a post-tax basis) at 31 December 2022, £940 million (2021: £937 million) is expected to be paid within one year. The consideration payable is expected to be paid over a number of years. As a result, the total estimated liabilities are discounted to their present values, on a post-tax basis using post-tax discount rates.

The Shionogi-ViiV Healthcare contingent consideration liability is discounted at 8% and the Novartis Vaccines contingent consideration liability is discounted partly at 7.5% and partly at 8.5%.



## Group financial review continued

## Financial position and resources continued

## Maturity profile of bond debt



## Net debt

<table><tr><td></td><td>2022
£m</td><td>2021
£m</td></tr><tr><td>Liquid investments</td><td>67</td><td>61</td></tr><tr><td>Cash and cash equivalents</td><td>3,723</td><td>4,274</td></tr><tr><td>Short term borrowings</td><td>(3,952)</td><td>(3,601)</td></tr><tr><td>Long term borrowings</td><td>(17,035)</td><td>(20,572)</td></tr><tr><td>Net debt the end of the year</td><td>(17,197)</td><td>(19,838)</td></tr></table>

At 31 December 2022, net debt was £17.2 billion, compared with £19.8 billion at 31 December 2021, comprising gross debt of £21.0 billion and cash and liquid investments of £3.8 billion. Net debt reduced by £2.6 billion primarily due to £3.3 billion free cash flow from continuing operations, £0.2 billion disposals of equity investments and £7.2 billion decrease from discontinued operations as a result of demerger primarily reflecting £7.1 billion of pre-separation dividends attributable to GSK funded by Consumer Healthcare debt. This was partly offset by purchases of businesses of £3.1 billion, net of cash acquired, reflecting the acquisitions of Sierra Oncology and Affinivax, dividends paid to shareholders of £3.5 billion, net adverse exchange impacts of £1.4 billion from the translation of non-Sterling denominated debt and exchange on other financing items and £0.1 billion purchases of equity investments.

At 31 December 2022, GSK had short-term borrowings (including overdrafts and lease liabilities) repayable within 12 months of £4.0 billion and £19 billion repayable in the subsequent year.

At 31 December 2022, GSK’s cash and liquid investments were held as follows:

<table><tr><td></td><td>2022
£m</td><td>2021
£m</td></tr><tr><td>Bank balances and deposits</td><td>1,324</td><td>2,825</td></tr><tr><td>US Treasury and Treasury repo only money market funds</td><td>146</td><td>54</td></tr><tr><td>Liquidity funds</td><td>2,253</td><td>1,395</td></tr><tr><td>Cash and cash equivalents</td><td>3,723</td><td>4,274</td></tr><tr><td>Liquid investments - government securities</td><td>67</td><td>61</td></tr><tr><td></td><td>3,790</td><td>4,335</td></tr></table>

Cash and liquid investments of £3.1 billion (2021: £2.9 billion) were held centrally at 31 December 2022.

The analysis of cash and gross debt after the effects of hedging is as follows:

<table><tr><td></td><td>2022
£m</td><td>2021
£m</td></tr><tr><td>Liquid investments</td><td>67</td><td>61</td></tr><tr><td>Cash and cash equivalents</td><td>3,723</td><td>4,274</td></tr><tr><td>Gross debt - fixed</td><td>(19,214)</td><td>(23,167)</td></tr><tr><td>- floating</td><td>(1,773)</td><td>(1,006)</td></tr><tr><td>Net debt</td><td>(17,197)</td><td>(19,838)</td></tr></table>

## Movements in net debt

<table><tr><td></td><td>2022
£m</td><td>2021
£m</td></tr><tr><td>Total net debt at beginning of year</td><td>(19,838)</td><td>(20,780)</td></tr><tr><td>Decrease in cash and bank overdrafts</td><td>(7,597)</td><td>(2,504)</td></tr><tr><td>Decrease in liquid investments</td><td>(1)</td><td>(18)</td></tr><tr><td>Net decrease in long-term loans</td><td>569</td><td>-</td></tr><tr><td>Net decrease of short-term loans</td><td>4,053</td><td>2,003</td></tr><tr><td>Repayment of lease liabilities</td><td>202</td><td>181</td></tr><tr><td>Debt of subsidiary undertaking acquired</td><td>(24)</td><td>-</td></tr><tr><td>Exchange adjustments</td><td>(1,531)</td><td>314</td></tr><tr><td>Other non-cash movements</td><td>(207)</td><td>(134)</td></tr><tr><td>Decrease/(increase) in net debt from continuing operations</td><td>(4,536)</td><td>(158)</td></tr><tr><td>Decrease/(increase) in net debt from discontinued operations</td><td>7,177</td><td>1,100</td></tr><tr><td>Total net debt at end of year</td><td>(17,197)</td><td>(19,838)</td></tr></table>



## Group financial review continued

## Financial position and resources continued

## Total equity

At 31 December 2022, total equity had decreased from £21,342 million at 31 December 2021 to £10,096 million.

A summary of the movements in equity is set out below:

<table><tr><td></td><td>2022
£m</td><td>2021
£m</td></tr><tr><td>Total equity at beginning of year</td><td>21,342</td><td>20,808</td></tr><tr><td>Total comprehensive income for the year</td><td>14,790</td><td>4,759</td></tr><tr><td>Non-cash distribution to non-controlling interests</td><td>(2,960)</td><td>-</td></tr><tr><td>Deconsolidation of former subsidiaries</td><td>(3,045)</td><td>-</td></tr><tr><td>Dividends to shareholders</td><td>(3,467)</td><td>(3,999)</td></tr><tr><td>Ordinary shares issued</td><td>25</td><td>21</td></tr><tr><td>Changes in non-controlling interests</td><td>(20)</td><td>-</td></tr><tr><td>Non-cash dividends to shareholders</td><td>(15,526)</td><td>-</td></tr><tr><td>Hedging gain/loss transferred to non-financial assets</td><td>9</td><td>-</td></tr><tr><td>Transaction with non-controlling interest</td><td>-</td><td>10</td></tr><tr><td>Share-based incentive plans</td><td>357</td><td>367</td></tr><tr><td>Tax on share-based incentive plans</td><td>(8)</td><td>11</td></tr><tr><td>Contributions from non-controlling interests</td><td>8</td><td>7</td></tr><tr><td>Distributions to non-controlling interests</td><td>(1,409)</td><td>(642)</td></tr><tr><td>Total equity at end of year</td><td>10,096</td><td>21,342</td></tr></table>

## Share purchases

At 31 December 2022, GSK held 217.1 million shares as Treasury shares (2021: 284.2 million shares), at a cost of £3,798 million (2021: £4,969 million), which has been deducted from retained earnings.

No ordinary shares were repurchased in the period 1 January 2023 to 9 March 2023 and the company does not expect to make any ordinary share repurchases in the remainder of 2023.

In 2022, 77.1 million Treasury shares were transferred to the Employee Share Ownership Plan (ESOP) Trusts, of which 50.3 million shares were transferred prior to share consolidation. Shares are held by the Trusts to satisfy future exercises of options and awards under the Group share option and award schemes.

A proportion of the shares held by the Trusts are in respect of awards where the rules of the scheme require GSK to satisfy exercises through market purchases rather than the issue of new shares. The shares held by the Trusts are matched to options and awards granted.

At 31 December 2022, the ESOP Trusts held 599 million (2021: 23.3 million) GSK shares against the future exercise of share options and share awards. The carrying value of £353 million (2021: £27 million) has been deducted from other reserves. The market value of these shares was £861 million (2021: £371 million).

## Contractual obligations and commitments

Financial commitments are summarised in Note 36 to the financial statements, 'Commitments'.

The following table sets out our contractual obligations and commitments at 31 December 2022 as they fall due for payment.

<table><tr><td></td><td>Total
£m</td><td>Under 1 yr
£m</td><td>1-3 yrs
£m</td><td>3-5 yrs
£m</td><td>5 yrs+
£m</td></tr><tr><td>Loans</td><td>20,086</td><td>3,786</td><td>3,213</td><td>2,259</td><td>10,828</td></tr><tr><td>Interest on loans</td><td>6,322</td><td>594</td><td>1,101</td><td>961</td><td>3,666</td></tr><tr><td>Finance lease obligations</td><td>1,008</td><td>167</td><td>328</td><td>177</td><td>336</td></tr><tr><td>Future Finance Charges on
leases</td><td>146</td><td>25</td><td>41</td><td>28</td><td>52</td></tr><tr><td>Lease contracts that have
not yet commenced</td><td>396</td><td>18</td><td>42</td><td>68</td><td>268</td></tr><tr><td>Intangible assets</td><td>10,659</td><td>317</td><td>590</td><td>1,616</td><td>8,136</td></tr><tr><td>Property, plant &
equipment</td><td>743</td><td>612</td><td>131</td><td>-</td><td>-</td></tr><tr><td>Investments</td><td>138</td><td>51</td><td>71</td><td>13</td><td>3</td></tr><tr><td>Purchase commitments</td><td>161</td><td>96</td><td>61</td><td>4</td><td>-</td></tr><tr><td>Pensions and post-
retirement benefits</td><td>345</td><td>345</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Total</td><td>40,004</td><td>6,011</td><td>5,578</td><td>5,126</td><td>23,289</td></tr></table>

Commitments in respect of loans and future interest payable on loans are disclosed before taking into account the effect of derivatives.

We have entered into a number of research collaborations to develop new compounds with other pharmaceutical companies. The terms of these arrangements can include upfront fees, equity investments, loans and commitments to fund specified levels of research. In addition, we will often agree to make further payments if future ‘milestones’ are achieved.

As some of these agreements relate to compounds in the early stages of development, the potential obligation to make milestone payments will continue for a number of years if the compounds move successfully through the development process. Generally, the closer the product is to marketing approval, the greater the probability of success. The amounts shown above within intangible assets represent the maximum that would be paid if all milestones were achieved. There was a decrease in the commitments in 2022 as a result of a reduction in outstanding loan commitments.



## Group financial review continued

## Financial position and resources continued

In connection with the demerger of Consumer Healthcare, the 31 December 2020 pension scheme valuations identified cash funding or technical provisions deficits in three GSK UK Pension Schemes. Scottish limited partnerships (“SLPs”) were established to provide a funding mechanism for each of GSK’s UK defined benefit pension schemes. The SLPs together hold shares representing 7.5% of the total issued share capital of Haleon.

Each pension scheme, through its SLP interest, is entitled to receive a distribution from that SLP in an amount equal to the net proceeds of sales of Haleon shares, and to receive dividend income on Haleon shares, until it has received an aggregate amount equal to an agreed threshold (“Proceeds Threshold”). The Proceeds Thresholds total £1,080 million (as increased by notional interest on the remaining balance from time to time), and payment of this amount would fully fund the cash funding or technical provisions deficits in the three schemes shown by the 31 December 2020 valuations. Once the Proceeds Threshold has been reached the GSK-controlled General Partner of each SLP is entitled to sell the remaining Haleon shares held by the SLP and distribute the proceeds to GSK. As at 31 December 2022, £345 million remains outstanding to the UK Pension Trustees.

## Contingent liabilities

Other contingent liabilities are set out in Note 35 to the financial statements, 'Contingent liabilities'.

The following table sets out contingent liabilities, comprising performance guarantees, letters of credit and other items arising in the normal course of business, and when they are expected to expire.

<table><tr><td></td><td>Total £m</td><td>Under 1 yr £m</td><td>1-3 yrs £m</td><td>3-5 yrs £m</td><td>5 yrs+ £m</td></tr><tr><td>Guarantees</td><td>12</td><td>8</td><td>3</td><td>—</td><td>1</td></tr><tr><td>Other contingent liabilities</td><td>46</td><td>10</td><td>—</td><td>11</td><td>25</td></tr><tr><td>Total</td><td>58</td><td>18</td><td>3</td><td>11</td><td>26</td></tr></table>

In the normal course of business, we have provided various indemnification guarantees in respect of business disposals in which legal and other disputes have subsequently arisen. A provision is made where an outflow of resources is considered probable and a reliable estimate can be made of the likely outcome of the dispute and this is included in Note 32 to the financial statements, 'Other provisions'.

We provide for the outcome of tax, legal and other disputes when an outflow of resources is considered probable and a reliable estimate of the outflow may be made. At 31 December 2022, other than for those disputes where provision has been made, it was not possible to make a reliable estimate of the potential outflow of funds that might be required to settle disputes where the possibility of there being an outflow was more than remote.

The ultimate liability for such matters may vary significantly from the amounts provided and is dependent upon negotiations with the relevant tax authorities and the outcome of litigation proceedings, where relevant. This is discussed further in ‘Principal risks and uncertainties’ on pages 285 to 295 and Note 47 to the financial statements, ‘Legal proceedings’.



## Approach to tax

Business makes a major contribution to the public purse through its tax contribution. This includes direct taxes (such as corporate income tax) and indirect taxes (such as VAT and customs duties) as well as other taxes (such as employment taxes and property taxes). It is therefore important that companies explain their approach to tax. This helps inform dialogue about tax and tax policy.

We are supportive of efforts to ensure companies are appropriately transparent about how their tax affairs are managed. As part of that, our Tax Strategy is set out in detail within the Public policies section of our website.

We support the exchange of country-by-country reporting (CBCR) data between tax authorities as, validated against existing information held on taxpayers, it will support their ability to ensure multinational groups pay the right amount of tax in the right places.

As a global biopharmaceutical company, we have a substantial business and employment presence in many countries around the world and pay a significant amount of tax. This includes corporate income tax and other business taxes, and tax associated with our employees. We also collect a significant amount of tax on behalf of governments along our supply chain, including from our employees.

We are subject to taxation throughout our supply chain. The worldwide nature of our operations means that our cross-border supply routes, necessary to ensure supplies of medicines into numerous countries, can result in conflicting claims from tax authorities as to the profits to be taxed in individual countries. This can lead to double taxation (with profits taxed in more than one country).

Profits are recognised in territories by reference to the activities performed there and the value they generate. To ensure the profits recognised in jurisdictions are aligned to the activity undertaken there, and in line with current OECD guidelines, we base our transfer pricing policy on the arm's length principle and support our transfer prices with economic analysis and reports.

We do not engage in artificial tax arrangements – those without business or commercial substance. We do not seek to avoid tax by the use of ‘tax havens’ or transactions we would not fully disclose to a tax authority. We have a zero-tolerance approach to tax evasion and the facilitation of tax evasion.

Tax risk in all countries in which we operate is managed through robust internal policies, processes, training and compliance programmes. Our Board of Directors and the Audit & Risk Committee are responsible for approving our tax policies and risk management arrangements as part of our wider internal control framework.
We seek to maintain open and constructive relationships with tax authorities worldwide, meeting regularly to discuss our tax affairs and real time business updates wherever possible.

We also monitor government debate on tax policy in our key jurisdictions so that we can understand and share an informed point of view regarding any potential future changes in tax law. Where relevant, we provide pragmatic and constructive business input to tax policy makers either directly or through industry trade bodies, advocating reform to support economic growth and job creation as well as the needs of our patients and other key stakeholders.

In 2022, the Group corporate tax charge was £707 million (2021 \( ^{①} $ ): £83 million) on profits before tax of £5,628 million (2021 \( ^{①} $ ): £3,599 million) representing an effective tax rate of 12.6% (2021 \( ^{①} \) ): 2.3%. We made cash tax payments of £1,310 million in the year (2021 \( ^{①} $ ): £972 million). In addition to the taxes we pay on our profits, we pay duties, levies, transactional and employment taxes.

Our Adjusted tax rate for 2022 was 15.5% (2021 \( ^{①} \) ): 15.9%. The rate has benefited from the closure of open issues with tax authorities in various jurisdictions. Subject to any material changes in our product mix, or other material changes in tax regulations or laws in the countries in which we operate, the Group’s average effective Adjusted tax rate for 2023 is expected to be around 15%.

The Group’s Total tax rate for 2022 of 12.6% (2021 \( ^{①} \) ): 2.3%) was lower than the Adjusted tax rate reflecting the different tax effects of various Adjusting items.

The UK Government has confirmed that the Spring Finance Bill 2023 will include legislation introducing a 15% global minimum corporate income tax rate, to have effect from 2024. The detail of the measures and how they are to be accounted for is still being finalised and so it is not possible to accurately quantify the impact for GSK at this stage.

Further details about our corporate tax charges for the year are set out in Note 14.

(1) The 2021 comparative results have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see page 238).



## Treasury policies

We report in Sterling and pay dividends out of Sterling cash flows. The role of Treasury is to monitor and manage the Group’s external and internal funding requirements and financial risks in support of our strategic objectives. GSK operates on a global basis, primarily through subsidiary companies, and we manage our capital to ensure that our subsidiaries are able to operate as going concerns and to optimise returns to shareholders through an appropriate balance of debt and equity. Treasury activities are governed by policies approved annually by the Board of Directors, and most recently on 12 October 2022. A Treasury Management Group (TMG) meeting, chaired by our Chief Financial Officer, takes place on a regular basis to review Treasury activities. Its members receive management information relating to these activities.

## Treasury operations

The objective of GSK’s Treasury activities is to minimise the post-tax net cost of financial operations and reduce its volatility in order to benefit earnings and cash flows. GSK uses a variety of financial instruments to finance its operations and derivative financial instruments to manage market risks from these operations. Derivatives principally comprise foreign exchange forward contracts and swaps which are used to swap borrowings and liquid assets into currencies required for Group purposes, as well as interest rate swaps which are used to manage exposure to financial risks from changes in interest rates.

Derivatives are used exclusively for hedging purposes in relation to underlying business activities and not as trading or speculative instruments.

## Capital management

GSK’s financial strategy, implemented through the Group’s financial architecture, supports GSK’s strategic priorities and is regularly reviewed by the Board. We manage the capital structure of the Group through an appropriate mix of debt and equity. We continue to manage our financial policies to a credit profile that particularly targets short-term credit ratings of A-1 and P-1 while maintaining single A long-term ratings consistent with those targets.

GSK’s long-term credit rating with Standard and Poor’s is A (stable outlook) and with Moody’s Investor Services (‘Moody’s’) is A2 (stable outlook). Our short-term credit ratings are A-1 and P-1 with Standard and Poor’s and Moody’s respectively.

## Liquidity risk management

GSK’s policy is to borrow centrally in order to meet anticipated funding requirements. Our cash flow forecasts and funding requirements are monitored by the TMG on a regular basis. Our strategy is to diversify liquidity sources using a range of facilities and to maintain broad access to financial markets.

Each day, we sweep cash to or from number of global subsidiaries to central Treasury accounts for liquidity management purposes.

## Interest rate risk management

GSK’s objective is to minimise the effective net interest cost and to balance the mix of debt at fixed and floating interest rates over time. The policy on interest rate risk management limits the net amount of floating rate debt to a specific cap, reviewed and agreed no less than annually by the Board.

## Foreign exchange risk management

Our objective is to minimise the exposure of overseas operating subsidiaries to transaction risk by matching local currency income with local currency costs where possible. Foreign currency transaction exposures arising on external and internal trade flows are selectively hedged. GSK’s internal trading transactions are matched centrally and we manage inter-company payment terms to reduce foreign currency risk. Where possible, we manage the cash surpluses or borrowing requirements of subsidiary companies centrally using forward contracts to hedge future repayments back into the originating currency.

In order to reduce foreign currency translation exposure, we seek to denominate borrowings in the currencies of our principal assets and cash flows. These are primarily denominated in US Dollars, Euros and Sterling.

Borrowings can be swapped into other currencies as required. Borrowings denominated in, or swapped into, foreign currencies that match investments in overseas Group assets may be treated as a hedge against the relevant assets. Forward contracts in major currencies are also used to reduce exposure to the Group’s investment in overseas Group assets. The TMG reviews the ratio of borrowings to assets for major currencies regularly.

## Commodity risk management

Our objective is to minimise income statement volatility arising from fluctuations in commodity prices, where practical and cost effective to do so. The TMG is authorised to approve the execution of certain financial derivatives to hedge commodity price exposures.

## Counterparty risk management

We set global counterparty limits for each of our banking and investment counterparties based on long-term credit ratings from Moody’s and Standard and Poor’s. Usage of these limits is actively monitored and any breach of these limits would be reported to the Chief Financial Officer immediately.

In addition, relationship banks and their credit ratings are reviewed regularly so that, when changes in ratings occur, changes can be made to investment levels or to authority limits as appropriate. All banking counterparty limits are reviewed at least annually.



## Critical accounting policies

The Group consolidated financial statements have been prepared in accordance with international accounting standards in conformity with the requirements of the Companies Act 2006 and the International Financial Reporting Standards (IFRS) as issued by the International Accounting Standard Board (IASB).

We are required to make estimates and assumptions that affect the amounts of assets, liabilities, revenue and expenses reported in the financial statements. Actual amounts and results could differ from those estimates.

The critical accounting policies relate to the following areas:

– Turnover

– Taxation (Note 14)

– Legal and other disputes (Notes 47)

– Contingent liabilities (Note 35)

– Pensions and other post-employment benefits (Note 31)

Information on the judgements and estimates made in these areas is given in Note 3 to the financial statements, 'Critical accounting judgements and key sources of estimation uncertainty'.

## Turnover

In respect of the Turnover accounting policy, our largest business is US Commercial Operations, and the US market has the most complex arrangements for rebates, discounts and allowances. The following briefly describes the nature of the arrangements in existence in our US Commercial Operations:

– We have arrangements with certain indirect customers whereby the customer is able to buy products from wholesalers at reduced prices. A chargeback represents the difference between the invoice price to the wholesaler and the indirect customer's contractual discounted price. Accruals for estimating chargebacks are calculated based on the terms of each agreement, historical experience and product growth rates

– Customer rebates are offered to key managed care and Group Purchasing Organisations and other direct and indirect customers. These arrangements require the customer to achieve certain performance targets relating to the value of product purchased, formulary status or pre-determined market shares relative to competitors. The accrual for customer rebates is estimated based on the specific terms in each agreement, historical experience and product growth rates
– The US Medicaid programme is a state-administered programme providing assistance to certain poor and vulnerable patients. In 1990, the Medicaid Drug Rebate Program was established to reduce state and federal expenditure on prescription drugs. In 2010, the Patient Protection and Affordable Care Act became law. We participate by providing rebates to states. Accruals for Medicaid rebates are calculated based on the specific terms of the relevant regulations or the Patient Protection and Affordable Care Act

– Cash discounts are offered to customers to encourage prompt payment. These are accrued for at the time of invoicing and adjusted subsequently to reflect actual experience

– We record an accrual for estimated sales returns by applying historical experience of customer returns to the amounts invoiced, together with market-related information such as stock levels at wholesalers, anticipated price increases and competitor activity

A reconciliation of gross turnover to net turnover for US Commercial Operations is as follows:

<table><tr><td rowspan="2"></td><td colspan="3">2022</td><td colspan="3">2021</td><td>2020</td></tr><tr><td>£m</td><td>Margin %</td><td>£m</td><td>Margin %</td><td>£m</td><td>Margin %</td><td></td></tr><tr><td>Gross turnover</td><td>29,814</td><td>100</td><td>24,432</td><td>100</td><td>24,570</td><td>100</td><td></td></tr><tr><td>Market-driven segments</td><td>(8,275)</td><td>(28)</td><td>(6,875)</td><td>(28)</td><td>(7,004)</td><td>(29)</td><td></td></tr><tr><td>Government mandated and state programmes</td><td>(6,218)</td><td>(21)</td><td>(5,134)</td><td>(21)</td><td>(5,710)</td><td>(23)</td><td></td></tr><tr><td>Cash discounts</td><td>(536)</td><td>(2)</td><td>(438)</td><td>(2)</td><td>(453)</td><td>(2)</td><td></td></tr><tr><td>Customer returns</td><td>(255)</td><td>(1)</td><td>(253)</td><td>(1)</td><td>(235)</td><td>(1)</td><td></td></tr><tr><td>Prior year adjustments</td><td>780</td><td>3</td><td>855</td><td>4</td><td>540</td><td>2</td><td></td></tr><tr><td>Other items</td><td>(768)</td><td>(2)</td><td>(673)</td><td>(3)</td><td>(560)</td><td>(2)</td><td></td></tr><tr><td>Total deductions</td><td>(15,272)</td><td>(81)</td><td>(12,518)</td><td>(51)</td><td>(13,422)</td><td>(55)</td><td></td></tr><tr><td>Net turnover</td><td>14,542</td><td>49</td><td>11,914</td><td>49</td><td>11,148</td><td>45</td><td></td></tr></table>

The reconciliation has been revised to include Vaccines as part of US Commercial Operations in all years.

Market-driven segments consist primarily of managed care and Medicare plans with which we negotiate contract pricing that is honoured via rebates and chargebacks. Mandated segments consist primarily of Medicaid and federal government programmes which receive government-mandated pricing via rebates and chargebacks.



## Group financial review continued

## Critical accounting policies continued

Overall sales deduction as a percentage of sales is consistent year over year with sales growth coming primarily from Trelegy and Specialty Products including ViiV. Deductions within the year were split approximately as follows: General Medicines 70%, Specialty Medicines 20% and Vaccines 10%.

At 31 December 2022, the total accrual for rebates, discounts, allowances and returns for US Commercial Operations amounted to £5,855 million (2021: £5,044 million).

A monthly process is operated to monitor inventory levels at wholesalers for any abnormal movements. This process uses gross sales volumes, prescription volumes based on third party data sources and information received from key wholesalers. The aim of this is to maintain inventories at a consistent level from year to year based on the pattern of consumption.

On this basis, US Commercial Operations inventory levels at wholesalers and in other distribution channels at 31 December 2022 were estimated to amount to approximately four weeks of turnover. This calculation uses third party information, the accuracy of which cannot be totally verified, but is believed to be sufficiently reliable for this purpose.

## Legal and other disputes

In respect of the accounting policy for Legal and other disputes, the following briefly describes the process by which we determine the level of provision that is necessary.

In accordance with the requirements of IAS 37, 'Provisions, contingent liabilities and contingent assets', we provide for anticipated settlement costs where an outflow of resources is considered probable and a reliable estimate may be made of the likely outcome of the dispute and legal and other expenses arising from claims against the Group.
We may become involved in significant legal proceedings, in respect of which it is not possible to meaningfully assess whether the outcome will result in a probable outflow, or to quantify or reliably estimate the liability, if any, that could result from ultimate resolution of the proceedings. In these cases, appropriate disclosure about such cases would be included in the Annual Report, but no provision would be made.

This position could change over time and, therefore, there can be no assurance that any losses that result from the outcome of any legal proceedings will not exceed by a material amount the amount of the provisions reported in the Group’s financial statements.

Like many pharmaceutical companies, we are faced with various complex product liability, anti-trust and patent litigation, as well as investigations of our operations conducted by various governmental regulatory agencies. Throughout the year, the General Counsel of the Group, as head of the Group's legal function, and the Senior Vice President and Head of Global Litigation for the Group, who is responsible for all litigation and government investigations, routinely brief the Chief Executive Officer, the Chief Financial Officer and the Board of Directors on the significant litigation pending against the Group and governmental investigations of the Group.

These meetings, as appropriate, detail the status of significant litigation and government investigations and review matters such as the number of claims notified to us, information on potential claims not yet notified, assessment of the validity of claims, progress made in settling claims, recent settlement levels and potential reimbursement by insurers.

The meetings also include an assessment of whether or not there is sufficient information available for us to be able to make a reliable estimate of the potential outcomes of the disputes. Often, external counsel assisting us with various litigation matters and investigations will also assist in the briefing of the Board and senior management. Following these discussions, for those matters where it is possible to make a reliable estimate of the amount of a provision, if any, that may be required, the level or provision for legal and other disputes is reviewed and adjusted as appropriate. These matters are discussed further in Note 47 to the financial statements, 'Legal proceedings'.

## Strategic report

The Strategic report was approved by the Board of Directors on 9 March 2023

Iain Mackay
Chief Financial Officer
9 March 2023



## Corporate
governance

<table><tr><td colspan="2">In this section</td></tr><tr><td>The Board and GSK Leadership Team</td><td>97</td></tr><tr><td>Chair&#x27;s governance statement</td><td>103</td></tr><tr><td>Corporate governance architecture</td><td>107</td></tr><tr><td>Ahead Together – Board oversight</td><td>110</td></tr><tr><td>Key decisions and engagements</td><td>112</td></tr><tr><td>Board committee reports</td><td>117</td></tr><tr><td>Directors&#x27; report</td><td>130</td></tr></table>



## The Board

Sir Jonathan Symonds, CBE
Non-Executive Chair
Age: 64
Nationality: British
Appointed: 1 September 2019



## Skills and experience

Jon has extensive international financial, life sciences and governance experience.
Jon served as an Independent Non-Executive Director of HSBC Holdings plc from April 2014, and as Deputy Group Chairman from August 2018, until his retirement from the Board in February 2020. He was previously Chairman of HSBC Bank plc, Chief Financial Officer of Novartis AG, Partner and Managing Director of Goldman Sachs, Chief Financial Officer of AstraZeneca plc, and a Partner at KPMG. His governance experience includes roles as Non-Executive Director and Chair of the Audit Committees of Diageo plc and QinetiQ Group plc, Non-Executive Chair of Proteus Digital Health Inc and Non-Executive Director of Rubius Therapeutics, Inc.

Jon is a Fellow of the Institute of Chartered Accountants in England and Wales.

## External appointments

Non-Executive Director, Genomics England Limited having previously served as its Chairman; Non-Executive Chair, Energy Aspects; Member, European Round Table for Industry; Senior Advisor to Chatham House.

## Dame Emma Walmsley
Chief Executive Officer

## Age: 53

Nationality: British
Appointed: 1 January 2017
Chief Executive Officer from
1 April 2017

## Skills and experience

Prior to her appointment as GSK’s CEO, Emma was the CEO of GSK Consumer Healthcare, a Joint Venture between GSK and Novartis, from its creation in March 2015. Emma joined GSK in 2010 from L'Oreal, having worked for 17 years in a variety of roles in Paris, London, New York and Shanghai. Emma was previously a Non-Executive Director of Diageo plc.

Emma holds an MA in Classics and Modern Languages from Oxford University.

External appointments
Independent director, Microsoft, Inc.

## Iain Mackay

Chief Financial Officer

## Skills and experience

Age: 61
Nationality: British
Appointed: 14 January 2019
Chief Financial Officer from
1 April 2019

Prior to joining GSK, Iain was Group Finance Director at HSBC Holdings plc, a position he held for eight years. A chartered accountant, Iain has lived and worked in Asia, the US and Europe and before HSBC was at General Electric, Schlumberger Dowell and Price Waterhouse. Iain was previously a Trustee of the British Heart Foundation and Chair of its Audit and Risk Committee.

Iain holds an MA in Business Studies and Accounting and holds an Honorary Doctorate from Aberdeen University in Scotland.

Iain is a member of the Institute of Chartered Accountants of Scotland.

Iain will step down as CFO and Executive Director on 1 May 2023. He will continue as an employee and leave the company on 31 December 2023.

## External appointments

Non-Executive Director, Chair of Audit & Risk Committee and member of Remuneration Committee, National Grid plc; Member, Court of the University of Aberdeen and Chair of its Remuneration Committee; Member, The 100 Group and Chair of its Stakeholder Communications and Reporting Committee.

## Elizabeth (Liz) McKee Anderson

Independent Non-Executive Director

Age: 65
Nationality: American
Appointed: 1 September 2022



## Skills and experience

Liz brings significant experience in commercial biopharmaceuticals and is a seasoned biotech board member. Her significant experience in commercial biopharmaceuticals, both operationally and at Board level, as well as her deep understanding of the biotechnology sector are invaluable to GSK as a pure biopharma company.

Prior to her current roles, Liz served as Worldwide Vice President and commercial leader in infectious diseases and vaccines and also for immunology and oncology at Janssen Pharmaceuticals, and as Vice President and General Manager at Wyeth Vaccines. Liz was also previously a Board member of Bavarian Nordic A/S and of Huntsworth Plc.

## External appointments

Board Member, BioMarin Pharmaceutical, Inc; Board Member, Revolution Medicines, Inc; Board Member, Insmed, Inc; Trustee, The Wistar Institute; Director, Aro Biotherapeutics Company.



## The Board continued

Charles Bancroft
Senior Independent Non-Executive
Director

Age: 63
Nationality: American
Appointed: 1 May 2020
Senior Independent Non-Executive Director
from 18 July 2022



## Dr Hal Barron

Non-Executive Director

Age: 60
Nationality: American
Appointed: 1 January 2018
Chief Scientific Officer and
President, R&D from 1 April 2018
Transitioned to the role of Non-Executive
Director on 1 August 2022



## Dr Anne Beal

Independent Non-Executive Director

Age: 60
Nationality: American
Appointed: 6 May 2021



## Skills and experience

Charlie has a wealth of financial and management experience in global biopharma.
Charlie retired from a successful career at Bristol Myers Squibb (BMS) in March 2020 where he held a number of leadership roles in commercial, strategy and finance. Beginning his career at BMS in 1984, he held positions of increasing responsibility within the finance organisation and had commercial operational responsibility for Latin America, Middle East, Africa, Canada, Japan and several Pacific Rim countries. He was appointed Chief Financial Officer in 2010, Chief Financial Officer and Executive Vice President, Global Business Operations in 2016 and Executive Vice President and Head of Integration and Strategy & Business Development in 2019. Charlie successfully steered BMS through a period of strategic transformation, including its $74 billion acquisition of Celgene. Charlie also served as a member of the Board of Colgate-Palmolive Company from 2017 until March 2020.

## External appointments

Board Member, Kodiak Sciences Inc; Board Member, BioVector Inc; Advisory Board Member, Drexel University's LeBow College of Business.
The Board determined that Charlie has recent and relevant financial experience and agreed that he has the appropriate qualifications and background to be an audit committee financial expert.

## Skills and experience

Hal joined GSK in 2018 as Chief Scientific Officer and President, R&D. On 1 August 2022, he transitioned to the role of Non-Executive Director, with additional responsibilities to support R&D.
Prior to joining GSK, Hal was President, R&D at Calico LLC (California Life Company), an Alphabet-funded company that uses advanced technologies to increase understanding of lifespan biology. Prior to this, Hal was Executive Vice President, Head of Global Product Development, and Chief Medical Officer of Roche, responsible for all the products in the combined portfolio of Roche and Genentech. At Genentech, he was Senior Vice President of Development and Chief Medical Officer. Hal was a Non-Executive Director and Chair of the Science & Technology Committee at Juno Therapeutics, Inc until March 2018, when it was acquired by Celgene Corporation. Hal previously served as a Non-Executive Board Director of GRAIL, Inc and an Advisory Board Member of Verily Life Sciences LLC.

## External appointments

CEO and Board Co-Chair, Altos Labs Inc; Associate Adjunct Professor, Epidemiology & Biostatistics, University of California, San Francisco.

## Skills and experience

Anne brings extensive healthcare experience to the Board as a physician and entrepreneur combined with a passion for patient advocacy. She is a recognised health policy expert in the development of global and national programmes for improving healthcare access for all patient groups and in ensuring the voice of patients is reflected in research programmes.

Prior to her current roles, Anne spent six years at Harvard Medical School and Massachusetts General Hospital, where she was an instructor in paediatrics. She has also held leadership roles at the Commonwealth Fund and the Aetna Foundation. Anne was previously Deputy Executive Director and Chief Engagement Officer for The Patient-Centered Outcomes Research Institute in the US and Chief Patient Officer and Global Head of Patient Solutions at Sanofi.

## External appointments

Founder and CEO, AbsoluteJOI Skincare; Board Member, AcademyHealth; Board Member, Prolacta Bioscience.



## The Board continued

Dr Harry (Hal) C Dietz
Independent Non-Executive Director
and Scientific & Medical Expert
Age: 64
Nationality: American
Appointed: 1 January 2022



## Skills and experience

Hal brings extensive experience in the field of human genetics which is central to GSK's approach to R&D. He is a former President of the American Society of Human Genetics and is recognised as the world's leading authority on a genetic disorder known as Marfan Syndrome. He also brings experience in development of novel therapies, in particular in relation to disease-modifying treatments for fibrotic and neurodegenerative diseases. In total, Hal has authored 282 original publications in peer-reviewed journals across his career.
As a physician scientist, he has dedicated his entire career to the care and study of individuals with heritable connective tissue disorders with primary perturbations of extracellular matrix homeostasis and function. His lab has identified the genes for many of these conditions, for which he uses model systems to elucidate disease mechanisms.

Hal has received multiple prestigious awards including the Curt Stern Award from the American Society of Human Genetics, the Colonel Harland Sanders Lifetime Achievement Award in Medical Genetics, the Taubman Prize for excellence in translational medical science, the Harrington Prize from the American Society for Clinical Investigation and the Harrington Discovery Institute, the Pasarow Award in Cardiovascular Research, the InBev-Baillet Latour Health Prize from the country of Belgium, and the Research Achievement Award from the American Heart Association.

He is an inductee of the American Society for Clinical Investigation, American Association for the Advancement of Science, Association of American Physicians, National Academy of Medicine, and National Academy of Sciences.

## External appointments

Victor A. McKusick Professor of Paediatrics, Medicine, and Molecular Biology & Genetics in the Department of Genetic Medicine, The Johns Hopkins University School of Medicine; Investigator, Howard Hughes Medical Institute; Consultant and Chair of Scientific Advisory Board, Aytu Biopharma; Independent Chair, GSK's Human Genetics Scientific Advisory Board; founded and previously Scientific Adviser to Blade Therapeutics.

## Dr Jesse Goodman

Independent Non-Executive Director and Scientific & Medical Expert

Age: 71
Nationality: American
Appointed: 1 January 2016



## Skills and experience

Jesse brings scientific and public health expertise to the Board’s deliberations. He has a wealth of experience spanning science, medicine, vaccines, regulation and public health, and has a proven record in addressing pressing public health needs from both the academic and federal sectors.
Jesse previously served in senior leadership positions at the US Food and Drug Administration (FDA), including most recently as the FDA’s Chief Scientist and previously as Deputy Commissioner for Science and Public Health and as Director of the Center for Biologics Evaluation and Research (CBER).

Jesse played a leadership role in developing the FDA’s Regulatory Science and Medical Countermeasures Initiatives and has worked collaboratively with industry, academia, government and global public health and regulatory partners to prepare for and respond to major public health threats, including emerging infectious diseases, disasters and terrorism. He led the FDA’s response to West Nile Virus and to the 2009 H1N1 influenza pandemic and served on the Senior Leadership Team for the 2010 White House Medical Countermeasure Review. Jesse was previously a member of both the Scientific Advisory Committee and the Regulatory and Legal Working Group of the Coalition for Epidemic Preparedness Innovations (CEPI).

## External appointments

Professor of Medicine and Attending Physician, Infectious Diseases, Georgetown University and directs the Georgetown University Center on Medical Product Access, Safety and Stewardship (COMPASS); Board Member (formerly President), United States Pharmacopeia (USP); Board Member, Scientific Counselors for Infectious Diseases, Centers for Disease Control and Prevention (CDC); Board Member, Intellia Therapeutics Inc; Member, US National Academy of Medicine; Board Member, Adaptive Phage Therapeutics, Inc.



## The Board continued

<table><tr><td>Urs Rohner
Independent Non-Executive Director</td><td>Skills and experience
Urs has a broad business, banking and legal background and extensive senior level experience at multinational companies.</td></tr><tr><td>Age: 63
Nationality: Swiss
Appointed: 1 January 2015</td><td>Urs has served as Chairman on a number of Boards, most recently for Credit Suisse Group from 2011 until April 2021. Prior to joining Credit Suisse in 2004, Urs served as Chairman of the Executive Board and CEO of ProSieben and ProSiebenSat.1 Media AG. This followed a number of years in private practice at major law firms in Switzerland and the US, having been admitted to the bars of the canton of Zurich in Switzerland in 1986 and the state of New York in the US in 1990.
External appointments
Member, International Advisory Board, Investcorp: Chair, Vega Cyber Associates AG.</td></tr><tr><td>Dr Vishal Sikka
Independent Non-Executive Director</td><td>Skills and experience
Vishal has a distinguished background in technology and particularly in the field of Artificial Intelligence (AI) and Machine Learning, which is central to GSK&#x27;s approach to R&amp;D. He is the founder and CEO of Vianai Systems, Inc, a Silicon Valley-based company that provides advanced technological software and services in AI and Machine Learning to large enterprises around the world.</td></tr><tr><td>Age: 55
Nationality: American
Appointed: 18 July 2022</td><td>Prior to founding Vianai Systems, Vishal served as CEO of Infosys Limited and as a member of the Executive Board of SAP SE. Vishal has a PhD in Artificial Intelligence from Stanford University and has co-authored several research abstracts related to AI, technology and database management.
External appointments
Founder and CEO, Vianai Systems, Inc; Board Member, Oracle Corporation; Member, Supervisory Board, BMV AG.</td></tr></table>

Key ▶ Committee Chair ☐ Corporate Responsibility ☐ Science ☑ Nominations & Corporate Governance ☒ Audit & Risk ☒ Remuneration

## Directors departing during 2022

<table><tr><td>Manvinder Singh (Vindi) Banga</td><td>1 Sept 2016 to July 2022</td><td></td></tr><tr><td>Dame Vivienne Cox</td><td>1 July 2016 to 18 July 2022</td><td>Retired from the Board on appointment to the Haleon plc Board effective on demerger</td></tr><tr><td>Lynn Elsenhans</td><td>1 July 2012 to 18 July 2022</td><td>Retired from the Board after nine years of service</td></tr><tr><td>Dr Laurie Glimcher</td><td>1 Sept 2017 to 10 Oct 2022</td><td>Retired from the Board after over five years of service</td></tr></table>



## GSK Leadership Team (GLT)

<table><tr><td colspan="2">Skills and experience</td></tr><tr><td>Emma Walmsley
Chief Executive Officer</td><td>Emma joined GSK in 2010 and the GLT in 2011. See Board biographies on pages 97 to 100.</td></tr><tr><td>Iain Mackay&#x27; 
Chief Financial Officer</td><td>Iain joined GSK and the GLT in 2019. See Board biographies on pages 97 to 100.</td></tr><tr><td>Diana Conrad
Chief People Officer</td><td>Diana was appointed Chief People Officer and member of the GLT in April 2019. She was previously Senior Vice President, HR, Pharmaceuticals R&amp;D from 2016 where she played a key strategic role as leader of the R&amp;D people and culture agenda to support its transformation. Diana joined GSK Canada&#x27;s HR team in 2000 where she held several roles of increasing responsibility before becoming Senior Vice President, HR for Consumer Healthcare in 2009. Prior to joining GSK, she held HR roles in companies including GE Capital, Gennum Corporation and Zenn Environmental Laboratories. Diana has an Honours Bachelor of Arts from McMaster University in Canada.</td></tr><tr><td>James Ford
SVP and Group General Counsel,
Legal and Compliance</td><td>James joined the GLT in 2018, when he was appointed Senior Vice President and Group General Counsel, later taking responsibility for Compliance, Corporate Security and Investigations in 2021. He joined GSK in 1995 and has served as General Counsel Consumer Healthcare, General Counsel Global Pharmaceuticals, Vice President of Corporate Legal and was Acting Head of Global Ethics and Compliance. Prior to GSK, James was a solicitor at Clifford Chance and DLA. He holds a law degree from the University of East Anglia and a Diploma in Competition Law from King&#x27;s College. He is qualified as a solicitor in England and Wales and is an attorney at the New York State Bar. James is based in London and has practised law and lived in the US, Singapore and Hong Kong. James was co-chair of the US-based Civil Justice Reform Group 2019-2022, and is a director of the European General Counsel Association and the Association of Corporate Counsel.</td></tr><tr><td>Sally Jackson
SVP, Global Communications
and CEO Office</td><td>Sally joined the GLT in March 2019 as Senior Vice President, Global Communications and CEO Office. She leads our Communications and Government Affairs function globally and is also the CEO&#x27;s Chief of Staff. Prior to this, Sally was Senior Vice President, Office of the CEO and CFO and she previously served as Head of Investor Relations. She joined GSK in 2001. Sally holds a degree in Natural Sciences from the University of Cambridge.</td></tr><tr><td>Luke Miels
Chief Commercial Officer</td><td>Luke joined GSK and the GLT in 2017. As Chief Commercial Officer he is responsible for our commercial portfolio of medicines and vaccines. Luke also co-chairs the Portfolio Investment Board with Tony Wood and is a member of the ViiV Healthcare Board. Outside of GSK, Luke is a member of the Singapore Economic Development Board. He previously worked for AstraZeneca as Executive Vice President of their European business and, prior to that, was Executive Vice President of Global Product and Portfolio Strategy, Global Medical Affairs and Corporate Affairs. Before that, he was head of Asia for Roche, based in Shanghai and then Singapore. Prior to that he held roles of increasing seniority at Roche and Sanofi-Aventis in the US, Europe and Asia. Luke holds a Bachelor of Science degree in Biology from Fildes University in Adelaide and a MBA from the Macquarie University, Sydney.</td></tr><tr><td>Shobie Ramakrishnan
Chief Digital and Technology Officer</td><td>Shobie joined the GLT in 2021 when she was appointed Chief Digital and Technology Officer. She joined GSK in 2018 and has deep and broad experience in both biotech and hi-tech companies and, most recently, has led Digital and Technology for GSK&#x27;s Global Commercial organisation, transforming the company&#x27;s capabilities in digital, data and analytics and playing a pivotal role in establishing a more agile commercial operating model. Before joining GSK, Shobie held senior technology leadership roles in organisations including AstraZeneca, Salesforce, Genentech and Roche. She is a former member of the board of directors at Remediant and is a member of the board of directors at SustainableIT.org. Shobie holds a Bachelor&#x27;s degree in Electronics Engineering from Vellore Institute of Technology, University of Madras, India.</td></tr></table>

1 Iain Mackay will step down from the Board and GLT from 2023. He will be succeeded as CFO by Julie Brown.



## GSK Leadership Team continued

<table><tr><td></td><td>Skills and experience</td></tr><tr><td>David Redfern
President, Corporate Development</td><td>David joined the GLT as Chief Strategy Officer in 2008 and is responsible for corporate development and strategic planning. Previously, he was Senior Vice President, Northern Europe with responsibility for GSK&#x27;s pharmaceutical businesses in that region and, before that, he was Senior Vice President for Central and Eastern Europe. He joined GSK in 1994. David was appointed Chairman of the Board of ViiV Healthcare Limited in 2011 and a Non-Executive Director of the Aspen Pharmacare Holdings Limited Board in 2015.
He has a Bachelor of Science degree from Bristol University and is a Chartered Accountant.</td></tr><tr><td>Regis Simard
President, Global Supply Chain</td><td>Regis joined the GLT in 2018, when he became President, Pharmaceuticals Supply Chain.
He is responsible for the manufacturing and supply of GSK&#x27;s medicines and vaccines. In addition, he leads Quality and Environment, Health, Safety and Sustainability at a corporate level. Regis joined GSK in 2005 as a Site Director in France, rising to become Senior Vice President of Global Pharmaceuticals Manufacturing before his current role. Previously, he held senior positions at Sony, Konica Minolta and Tyco Healthcare. He is a member of the Board of ViiV Healthcare.
He is a mechanical engineer and holds an MBA.</td></tr><tr><td>Phil Thomson
President, Global Affairs</td><td>Phil joined the GLT in 2011. He was appointed President, Global Affairs in 2017, and has responsibility for the Group&#x27;s strategic approach to stakeholder engagement, reputation and policy development. Previously, Phil was Senior Vice President, Communications and Government Affairs. He joined Glaxo Wellcome as a commercial trainee in 1996.
Phil is also Chair of The Whitehall &amp; Industry Group and holds a degree in English, History and Russian Studies from Durham University.</td></tr><tr><td>Deborah Waterhouse
CEO, ViiV Healthcare and President, GSK Global Health</td><td>Deborah was appointed to the GLT in January 2020. She became Chief Executive Officer of ViiV Healthcare in April 2017. In addition to ViiV, Deborah also leads GSK&#x27;s Global Health organisation.
Deborah joined GSK in 1996 and, prior to ViiV, was the Senior Vice President of Primary Care within GSK&#x27;s US business. She has a strong track record of performance in both specialty and primary care. Deborah led the HIV business in the UK before heading the HIV Centre of Excellence for Pharma Europe and held roles as General Manager of Australia and New Zealand and Senior Vice President for Central and Eastern Europe.
Deborah is a Non-Executive Director of Schroders plc and holds a degree in Economic History and English Literature from Liverpool University.</td></tr><tr><td>Tony Wood
Chief Scientific Officer</td><td>Tony was appointed Chief Scientific Officer (CSO) designate on 19 January 2022 and became CSO, Head of R&amp;D and a member of GLT on 1 August 2022. He joined GSK from Pfizer in 2017 as Senior Vice President, Medicinal Science and Technology, responsible for all science and technology platforms driving the delivery of new innovation.
Tony has led large-scale global organisations in drug discovery and development in multiple therapeutic areas, including immunology, oncology and infectious diseases. During his time at Pfizer, Tony was responsible for the invention of a new antiretroviral medication used to treat HIV infection. He is a Fellow of the Academy of Medical Sciences, an Honorary Fellow of the Royal Society of Chemistry (RSC), the highest honour given by the RSC, and a Fellow of the Royal Society of Biology.
Tony has a BSc in chemistry and PhD in organic synthesis from the University of Newcastle, and was a postdoctoral fellow at Imperial College, London. He is also currently a visiting professor at IMCM Oxford.</td></tr></table>

## GLT members departing during 2022

Hal Barron was a member of the GLT and Chief Scientific Officer until 1 August 2022, when he transitioned to a Non-Executive Director. Roger Connor was a member of the GLT and President, Global Vaccines until 1 December 2022, when he left the company.



## Chair's governance statement

2022 was one of the most important years in GSK’s recent history which saw the delivery of strong operational and financial performance, the successful demerger of Consumer Healthcare and the establishment of new GSK as a fully focused global biopharma company.

There was an intensity to the Board’s work in supporting and overseeing this, which required a number of additional meetings to be scheduled, as illustrated below.

## 2022 Board activity

Pre-demerger (1 January to 17 July)

<table><tr><td></td><td>Routine</td><td>Additional \( ^{*} \)</td></tr><tr><td>Board</td><td>3</td><td>3</td></tr><tr><td>Nominations &amp; Corporate Governance</td><td>3</td><td>1</td></tr><tr><td>Science</td><td>1</td><td>2</td></tr><tr><td>Corporate Responsibility</td><td>1</td><td>1</td></tr><tr><td>Audit &amp; Risk</td><td>3</td><td>2</td></tr><tr><td>Remuneration</td><td>3</td><td>2</td></tr><tr><td>Chairs&#x27;</td><td>0</td><td>5</td></tr></table>

 \( ^{*} \) Additional activity:

– Development and approval of demerger documentation and forecast

– Haleon plc (Haleon): Chair appointment and Board development

– GSK Remuneration policy development and investor approval

– GSK Board development and CSO succession

– Business development

Post-demerger (18 July to 31 December)

<table><tr><td></td><td>Routine</td><td>Additional \( ^{*} \)</td></tr><tr><td>Board</td><td>3</td><td>2</td></tr><tr><td>Nominations &amp; Corporate Governance</td><td>2</td><td>0</td></tr><tr><td>Science</td><td>2</td><td>1</td></tr><tr><td>Corporate Responsibility</td><td>3</td><td>0</td></tr><tr><td>Audit &amp; Risk</td><td>3</td><td>2</td></tr><tr><td>Remuneration</td><td>3</td><td>1</td></tr><tr><td>Chairs&#x27;</td><td>0</td><td>1</td></tr></table>

 \( ^{*} \) Additional activity:

– CFO succession

– Zantac litigation

– Business development

## Executing the demerger and creating new GSK

The Board’s work in the first half of the year was primarily occupied in overseeing the smooth execution of the demerger of Consumer Healthcare from GSK, resulting in the creation of two strong businesses. This culminated in the approval of the GSK Circular and the Haleon Prospectus which were overwhelmingly approved by shareholders at the General Meeting in July, with over 99% of votes cast in favour. This work

## 2022 separation process

– Disciplined Board approach to deliver demerger

– Creation of world-leading consumer healthcare business with competitive long-term growth prospects and compelling financial proposition

– Newly focused GSK with strengthened balance sheet for investment in pipeline/R&D

– Both companies with clear targets for upper-quartile growth, set out at Investor Updates
included, at its heart, a robust focus on shareholder value creation embodied in the ambitions for both companies. These were communicated in the investor updates in February 2022 for Haleon and previously in June 2021 for GSK.






## Chair's governance statement continued

At our investor updates, we set out what we believed to be competitive financial aspirations for new GSK. Namely: cumulative top-line growth of 5% and operating profit growth of 10% (excluding COVID-19 solutions), together with an aspiration of £31 billion to £33 billion of sales by 2031. This was not an ambition that the Board entered into lightly. It was a very important demonstration of the confidence the Board has in the business and our determination to be held accountable for a step-change in improved performance. 2022's strong operational and financial performance is a good platform to progress from.

Similarly, for Haleon, the focus was on a top-line growth aspiration to signal that the business had upper quartile growth potential. This view was robustly tested when an unsolicited conditional and non-binding proposal to acquire the Consumer Healthcare business was received. In exercising its fiduciary duties all proposals were evaluated but rejected by the Board as they were not in the best interests of shareholders. This is because the proposals fundamentally undervalued the Haleon business and its future prospects. The Board was confident that Haleon could deliver sustained organic sales growth in the range of 4-6% CER over the medium term. It has been very pleasing to see that since separation, Haleon has subsequently announced strong performance.

A key part of our aspiration for GSK was the restructuring of the GSK balance sheet with an appropriate level of debt for Haleon. This sought to ensure the competitiveness of both companies on separation and GSK’s ability to continue to invest in external as well as internal science was improved. The refinancing of approximately £10 billion of indebtedness was successfully completed in the first quarter of 2022. This timing was opportune given the current environment. GSK received £7.1 billion of pre-separation dividends attributable to GSK funded by Consumer Healthcare debt and we continue to hold 13.5% of Haleon shares, which will be divested in due course.

## R&D and business development

I have also previously described the succession process we followed for the CSO transition from Dr Hal Barron to Dr Tony Wood. We are very pleased with how smooth this process has been and that we are making good progress in R&D. The Board receives regular reports on R&D from Dr Wood as well as from the Science Committee, following its reviews. Progress is achieved by organic and inorganic business development (BD).

We now have an efficient Board cadence for BD to support R&D. The scientific screening of a target is undertaken first by the Science Committee, well in advance of the Board’s consideration. This is to ensure that we are confident with the scientific rationale underpinning a deal before progressing to the Board. If the proposal is for a late or later stage target or asset, we then also undertake a commercial review of the forecasts and the commercial assumptions underpinning it. We consider deals in respect of their contribution to our ambitions for the periods: to 2026, 2026 to 2031, and beyond. The Board can then review the proposal knowing that these important aspects have been established. We then focus on the value associated with the transaction and how it contributes to furthering our strategy and plan.

During 2022, this process included the appraisal and approval of the acquisitions of:

– Sierra Oncology, a biopharmaceutical company focused on targeted therapies for rare forms of cancer. The acquisition included memolitinib, a new medicine with a unique dual mechanism of action intended to address the critical unmet medical needs of myelofibrosis patients with anaemia

– Affinivax, a clinical stage biopharmaceutical company providing GSK with access to a next generation pneumococcal vaccine candidate and a highly innovative Multiple Antigen Presenting System, known as MAPS

Other transactions reviewed by the Board included:

– a licensing agreement with Spero Therapeutics for tebipenem HBr, a late-stage antibiotic targeted to treat complicated urinary tract infections; a significant unmet medical need

– a collaboration with Wave Life Sciences, bringing together Wave’s oligonucleotide platform and GSK’s expertise in genetics and genomics

– a collaboration with Tempus to provide GSK with access to Tempus' AI-enabled platform, including its library of de-identified patient data – one of the world’s largest sources of clinical and molecular data

## Shareholder perspectives and engagement

The Board believes in the importance of maintaining a high and continuous level of engagement with shareholders. During 2022 and up to the date of publication of this Report, I held 27 individual meetings with a range of investors, who make up approximately 35% of the company’s share register. Charles Bancroft, who was appointed our new SID after the demerger, has held 14 introductory meetings with shareholders making up over 25% of our register. We were also pleased to be able to hold our Annual Governance Meeting in London in December 2022 as an ‘in person’ meeting once again. We extended an invitation to shareholders representing holdings totalling approximately 50% of our share register to this event and were pleased that representatives of over 25% participated virtually or in person. It is of prime importance for us to maintain a clear understanding of investors’ views on the company’s performance. These meetings help achieve that and provide a key input to our Board planning.



## 2023 Board priorities

Externally facilitated Board review to agree priorities and ways of working

Focus on value creation, governance and oversight of Ahead Together strategy:

– Delivery of performance targets

– Execution of R&D pipeline and business development

– Long-term R&D strategy and approach

– People/Talent/Culture

– ESG Leadership

– Zantac litigation – defence and mitigation

– Focus on shareholder value creation

## New GSK Board priorities

When I joined the Board in September 2019, GSK was entering a period of significant transition in the run up to the separation of the Group. The Board engaged in a structured, externally facilitated appraisal of our governance and the architecture of the Board and its committees. The output of this was a Board agenda that was focused and linked directly to the business needs of innovation, pipeline, performance, culture and separation, and a refined committee architecture that reinforced these priorities.

Following separation, it was time to set new Board priorities. Ms Hall of No 4, a business advisory company, was engaged to facilitate this work following the success of her previous review. This work comprised two key aspects:

– a review of our current ways of working, with recommendations for further improvement and establishing priorities for the Board agenda for the next three to five years

– an evaluation of the Board and its committees during 2022

The Board is now aligned with management to deliver our new Ahead Together purpose, strategy and culture, with a strong emphasis on value creation over three time periods: near-term (2023-26) based around delivering our public commitments; medium- to long-term (2026-31); and beyond. Our Board programme for 2023 has been set accordingly.

The report of the formal independent external 2022 Board and committee performance review is set out on page 111.

## Board culture and decision-making

The Board fully supported our new purpose, strategy and the performance culture for new GSK. We are now well-positioned to deliver on our public commitments for growth and to create sustainable long-term value. All Board discussions focus on the powerful combination of Science, Technology and Talent and realising GSK’s desired culture. These support our aim to be:

– ambitious for patients

– accountable for impact

– doing the right thing



They also frame Board discussions when considering strategic decisions and actions to be taken.

## Connecting with the business and our people

Following the COVID-19 restrictions, the Board is now able to meet together in person. Time is set aside to enable our Non-Executive Directors to have more informal time, together with the GLT members presenting to them and to meet with other colleagues at each meeting location.

## The Board and Board committees

The Board’s agenda seeks to be focused and not to duplicate work. Each committee remit defines its agenda to support our priorities. Our Committee Chairs continue to be responsible for sharing with the Board the work their committees undertake and the main issues they are overseeing. They also highlight specific committee papers which they believe would benefit the Board’s wider understanding. Non-Executive Directors may attend any committee meeting and have full access to agendas and papers. From time to time the Chairs’ Committee, or a more specific Board committee, may be convened for a specific topic. This creates flexibility and enables the Board to be more agile, if required. Given the increased biopharma expertise of the new Board, management has also been sharing proposals and opportunities at an earlier stage to facilitate more efficient decision-making.

The following is a snapshot of aspects of our Board committees, work in 2022.

Audit & Risk Committee: assisted in the establishment of a robust internal control and risk management control framework for Haleon as an independent listed company. It also confirmed that GSK’s framework remained fit for our new future. The Committee took a lead role in completing the scrutiny of and then subsequently recommending to the Board the demerger and listing documents for shareholder approval at the General Meeting in July 2022.



## Chair's governance statement continued

Since the demerger, the Group’s share price performance in the second half of the year was impacted by the uncertainties associated with the Zantac product liability litigation in the US. The Committee continues to have primary Board accountability for the Zantac litigation, including accounting, disclosure and communication assessments on behalf of the Board. The Committee has a clear remit and recommends decisions on the navigation of the litigation to the Board, as appropriate. I would reiterate at this point that the company remains very confident in its position on these matters and will defend itself vigorously against any claims brought.

Nominations & Corporate Governance Committee: supported the demerger of the Consumer Healthcare business by assisting the Haleon Chair designate in completing the composition of the Haleon Board. This included the transfer, on demerger, of two of our serving Directors, Vindi Banga and Dame Vivienne Cox. The Committee felt strongly that their particular skills and experience would be valuable to Haleon and that they would also importantly provide continuity for the new Haleon Board.

The Committee’s other focus was on continuing to complete the composition of the new GSK Board and changes to the GLT. The key focus was in deepening the Board’s scientific and biopharma skills. The Committee selected new Directors with a strong emphasis on life sciences and technology to help deepen our biopharma expertise and experience:

– Dr Vishal Sikka is a world-leading technologist in the field of advanced enterprise technologies with extraordinary credentials in AI and machine learning

– Liz McKee Anderson has deep commercial expertise across both large and specialty biopharma and has specific experience of global commercialisation and market access in specialisms such as respiratory, immunology, vaccines and HIV

– Julie Brown, will join GSK in April as our incoming CFO. She has considerable listed pharmaceuticals and commercial experience

The Board now has scientific credentials ideally suited to its new purpose and which are among the strongest in the industry. We have moved away from the broader experience on the Board I originally joined in 2019. I am pleased at how the debate and discussion in Board and committee meetings has evolved to our new purpose and is deeper and more enriched as a result. The Committee will continue to recruit diverse Directors with scientific and biopharma expertise to meet the evolving needs of the Board to oversee the company’s strategy as a global biopharma business.
Science Committee: Good progress has been made in R&D. The Committee continues to support the ambitious and agile development of our pipeline, both organically and through smart business development, by overseeing and reviewing our application of science. The Committee supported the seamless transition of leadership of R&D to Dr Tony Wood from Dr Hal Barron. Tony’s role as a key architect in rebuilding our pipeline was key to this.

Corporate Responsibility Committee: The new culture at GSK is something that we all own. It powers our purpose, drives delivery of our strategy and helps make GSK a place where people can thrive. The Committee continues to focus its oversight on evolving the company’s ESG performance. I am pleased that we are able to report that we are on track against our new ESG rating and reassured by the further enhancements to our ESG reporting and data oversight.

Remuneration Committee: Our focused new Remuneration policy is a fundamental part of the architecture of new GSK post-separation. It is critical we now build a strong performance culture to generate sustained delivery of shareholder value. Our new policy seeks to achieve this key linkage between executive remuneration rewarding outperformance.

We engaged extensively with shareholders and shareholder representative bodies as we developed the new policy to recognise the importance of the new reward system to support new GSK’s success. The final policy was modified to reflect the feedback we received, whilst recognising the sizeable minority of shareholders who voted against it. We will continue to engage with shareholders to demonstrate the importance we place on rewarding over-performance in the policy at this crucial next stage of new GSK’s development. The strong operational and financial performance of the company in 2022 is an encouraging start. However, GSK has underperformed in terms of TSR and share price performance for many years. The new policy is firmly focused on addressing and reversing this trend and the outturns of awards in 2022 recognise the significant improvement in performance.

Overall good progress was made in 2022. However, your Board is clear that there is more to do to increase investor confidence in the ability of the Group to sustain growth over the next decade.

Thank you for your continued support and I look forward to connecting with you during the year, whether at our Annual General Meeting in May, or otherwise, to share our continued progress.

Sir Jonathan Symonds
Chair
9 March 2023



## Corporate governance architecture



Our corporate governance architecture is a framework designed to improve the effectiveness of the Board and to support its oversight of the GSK Leadership Team (GLT) in the delivery of our strategy. It continues to evolve to support our infrastructure and priorities as a pure biopharma business.

GSK’s internal control and risk management arrangements are an integral part of our overall corporate governance framework and are described on pages 51 to 64 and pages 125 and 126.

To ensure the framework’s optimal effectiveness it requires:

– a clear division of responsibilities for individual and collective Board roles described on the next page

– the appropriate distribution of workload to the Board committee with the requisite focus and skills

– highly committed Board Directors motivated to discharge their roles and responsibilities for the success of the company

<table><tr><td colspan="3">Committee roles</td><td rowspan="2">Membership</td><td rowspan="2">Committee report on page</td></tr><tr><td>Committee</td><td>Role and focus</td><td></td></tr><tr><td>Chairs&#x27;</td><td>Acts on behalf of the Board between its scheduled meetings to take decisions on urgent matters in accordance with matters and authority delegated to it by the Board from time to time</td><td>Sir Jonathan Symonds (Company Chair) Senior Independent Director Chairs of the Board&#x27;s committees</td><td>-</td><td></td></tr><tr><td>Corporate Responsibility</td><td>Considers GSK&#x27;s Trust priority and has oversight of our responsible business approach and ESG strategy, performance and reporting. This reflects the most important issues for responsible and sustainable business growth. It has oversight of the views and interests of our internal and external stakeholders and reviews issues that have the potential for serious impact upon GSK&#x27;s business and reputation</td><td>Dr Anne Beal (Chair) Dr Jesse Goodman Dr Vishal Sikka</td><td>117-118</td><td></td></tr><tr><td>Science</td><td>Supports the Board in its understanding of the key strategic themes, upon which the company&#x27;s R&amp;D strategy is based, and of external transactions, by performing in-depth reviews of the underlying scientific assumptions to give the Board technical assurance. It also undertakes more in-depth risk oversight of R&amp;D-related risks</td><td>Dr Hal Dietz (Chair from 1 January 2023) Dr Jesse Goodman (Chair to 31 December 2022) Dr Hal Barron</td><td>118-120</td><td></td></tr><tr><td>Nominations &amp; Corporate Governance</td><td>Reviews the structure, size and composition of the Board, the appointment of members to Board committees and the appointment of Corporate Officers. It makes recommendations to the Board as appropriate. It also plans and assesses orderly succession for Executive and Non-Executive Directors and reviews management&#x27;s Succession Plan to ensure its adequacy</td><td>Sir Jonathan Symonds (Chair) Charles Bancroft Dr Anne Beal Urs Rohner</td><td>120-124</td><td></td></tr><tr><td>Audit &amp; Risk</td><td>Is responsible for reporting to the Board, overseeing and monitoring corporate governance arrangements and for making recommendations to the Board to ensure the company&#x27;s standards and arrangements are consistent with existing corporate governance standards and emerging best practice. It also reviews Board and GLT conflicts of interest</td><td>Charles Bancroft (Chair) Elizabeth McKee Anderson Urs Rohner</td><td>124-129</td><td></td></tr><tr><td>Remuneration</td><td>Reviews the financial reporting process, the integrity of the company&#x27;s financial statements, the external and internal audit process, the system of internal control and the identification and management of risks, and the company&#x27;s process for monitoring compliance with laws, regulations and ethical codes of practice. It also oversees ESG data reporting and assurance</td><td>Charles Bancroft (Chair) Elizabeth McKee Anderson Urs Rohner</td><td>124-129</td><td></td></tr><tr><td></td><td>Initiates audit tenders, the selection and appointment of the external auditor, setting its remuneration and exercising oversight of its work</td><td></td><td></td><td></td></tr><tr><td>Remuneration</td><td>Sets the company&#x27;s Remuneration policy having regard to GSK&#x27;s workforce remuneration so that GSK is able to recruit, retain and motivate its executives</td><td>Urs Rohner (Chair) Charles Bancroft Dr Anne Beal Elizabeth McKee Anderson</td><td>132-164</td><td></td></tr><tr><td></td><td>The Remuneration policy is regularly reviewed to ensure that it is consistent with the company&#x27;s scale and scope of operations, supports the business strategy and growth plans, is aligned to the wider workforce and helps drive the creation of shareholder value</td><td></td><td></td><td></td></tr><tr><td></td><td>(The Chair and the CEO are responsible for evaluating and making recommendations to the Board on the remuneration arrangements and policy for the Non-Executive Directors)</td><td></td><td></td><td></td></tr></table>

Each Board committee has written terms of reference which are approved by the Board and are reviewed at least annually to ensure that they comply with the latest legal and regulatory requirements and reflect best practice developments. The current full terms of reference of each Board committee are available on gsk.com. Board and committee meeting attendance for 2022 and oversight of the company's policy on external appointments is set out on page 109.



## Corporate governance architecture continued

## Leadership

Chair

Jonathan Symonds

– leads and manages the business of the Board
– provides direction and focus
– ensures a clear structure for effective operation of the Board and its committees
– maintains a dialogue with shareholders about the governance of the company
– sets the Board agenda and ensures sufficient time is allocated to promote effective debate to support sound decision-making
– ensures the Board receives accurate, timely and clear information
– meets continuously with each Non-Executive Director to discuss individual contributions and performance, together with training and development needs
– shares peer feedback that is provided as part of the Board evaluation process
– meets regularly with all the Non-Executive Directors independently of the Executive Directors
+ The Chair’s role description is available on gsk.com

## Chief Executive Officer

## Emma Walmsley

– is responsible for the management of the Group and its business
– develops the Group’s strategic direction for consideration and approval by the Board
– implements the agreed strategy
– is supported by members of the GLT
– maintains a continual and active dialogue with shareholders in respect of the company’s performance
+ The Chief Executive Officer’s role description is available on gsk.com

## Independent oversight and rigorous challenge

## Non-Executive Directors

– provide a strong independent element to the Board
– constructively support and challenge management and scrutinise its performance in achieving agreed deliverables
– shape proposals on strategy and offer specialist advice to management
– each has a letter of appointment setting out the terms and conditions of their directorship
– devote such time as is necessary to the proper performance of their duties
– are expected to attend all meetings as required

## Independence statement

The Board considers all of its Non-Executive Directors who are identified on pages 97 to 100, with the exception of Dr Hal Barron, to be independent after being assessed against Provision 10 of the Financial Reporting Council’s (FRC) UK Corporate Governance Code (Code).
The independence and commitment of Dr Jesse Goodman and Urs Rohner, who have each served on the Board for over six years, has been subjected to a rigorous review.

+ GSK’s Non-Executive Director role description is available on gsk.com

## Senior Independent Director

## Charles Bancroft

– acts as a sounding board for the Chair and a trusted intermediary for other Directors
– together with the Non-Executive Directors, leads the annual review of the Chair’s performance, taking into account the views of the Executive Directors
– discusses the results of the Chair’s effectiveness review with the Chair
– leads the search and appointment process and makes the recommendation to the Board for a new Chair
– acts as an additional point of contact for shareholders, maintains an understanding of the issues and concerns of major shareholders through meetings with investors and briefings from the Company Secretary and Investor Relations
+ GSK’s Senior Independent Non-Executive Director’s role description is available on gsk.com

## Company Secretary
Victoria Whyte

– is secretary to the Board and all Board committees

– supports the Board and Committee Chairs in annual agenda planning
– ensures information is made available to Board members in a timely fashion
– supports the Chair in designing and delivering Board inductions
– coordinates continuing business awareness and training requirements for the Non-Executive Directors
– undertakes internal Board and committee evaluations at the request of the Chair
– advises the Directors on Board practice and procedures, and corporate governance matters
– chairs the Group’s Disclosure Committee
– operates a Board-approved appointments policy that reflects the Board and external appointment requirements of the Code
– is a point of contact for shareholders on all corporate governance matters



## Corporate governance architecture continued

<table><tr><td colspan="9">2022 Board and committee attendance</td></tr><tr><td></td><td>Board</td><td>Chairs&#x27;</td><td>Corporate Responsibility</td><td>Science</td><td>Nominations &amp; Corporate Governance</td><td>Audit &amp; Risk</td><td>Remuneration</td><td></td></tr><tr><td>Total number of routine meetings</td><td>6</td><td>6</td><td>4</td><td>3</td><td>5</td><td>6</td><td>6</td><td></td></tr><tr><td>Current members</td><td>Attended</td><td></td><td>Attended</td><td>Attended</td><td>Attended</td><td>Attended</td><td>Attended</td><td></td></tr><tr><td>Sir Jonathan Symonds</td><td>6</td><td>6</td><td></td><td></td><td>5</td><td></td><td></td><td></td></tr><tr><td>Emma Walmsley</td><td>6</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Iain Mackay</td><td>6</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr></table>

The numbers in brackets denote the number of meetings which these individuals were eligible to attend. See Board and committee changes during 2022 on page 123. Details of committee members' skills and experience are included in their biographies under 'The Board' on pages 97 to 100.

## FRC UK Corporate Governance Code

## Financial experience

In accordance with the FRC’s Code, the Board has determined that Charles Bancroft has recent and relevant financial experience. It has also agreed that he has the appropriate qualifications and background to be an audit committee financial expert as defined by the Sarbanes-Oxley Act of 2002, and has determined that he is independent within the meaning of the Securities Exchange Act of 1934, as amended.

## Compliance

The Board is pleased to report that in 2022 it was in full compliance with the provisions of the FRC’s Code, with the exception of Code provision 38.
Provision 38 requires alignment of pension rates for executive directors with those available to the local workforce. Since 1 January 2023, current Executive Directors' pension rates have been aligned to the wider workforce local to them. This replicates the requirement for pension arrangements for any new Executive Directors appointed to GSK.

In addition, provision 38 requires that only base salary should be pensionable. US pension arrangements for employees allow basic salary and bonus to be pensionable. Following Dr Hal Barron’s transition to a Non-Executive Director with effect from 1 August 2022, this FRC Code requirement has also been met.

The Board is also pleased to report that it has consistently applied the principles of the FRC’s Code, as set out in the pages of this and the Remuneration report. A copy of the Code is available on the FRC’s website, www.frc.org.uk.

All our Non-Executive Directors are expected to devote such time as is necessary for the performance of their duties. Each Director is required to attend a minimum of 75% of scheduled Board and committees meetings. However, it is recognised that there may be rare occasions when this is not possible. Special allowance is given during the first year of Board membership while calendars are aligned. There was a high attendance record at scheduled Board and committee meetings for all our Directors who served during 2022, as set out above.

Our Board Directors’ external appointments are governed by a Board approved policy. External appointments can help Board and GLT members widen their expertise and knowledge and hence perform their roles more effectively. When proposing new Non-Executive Director appointments to the Board for approval, the Board takes into account other demands on the individuals’ time. Prior to appointment to the Board, an individual is required to disclose significant commitments they may have with an indication of the time involved.

All additional prospective external appointments for serving Board Directors are considered and approved by the Board, noting the nature of the role and type of organisation, time commitment and any potential conflicts that are envisaged.

The Company Secretary maintains a register of commitments and potential conflicts. The Board is satisfied that given Directors’ other interests, each has sufficient time to carry out their role. Our Executive or Non-Executive Directors may undertake a maximum of one, or up to four listed company directorships, respectively.



## Ahead Together – Board oversight

The Board discharges its responsibilities through an annual programme of meetings.

In 2022, papers and presentations were provided to the Board (and its committees) which were focused on the strengthening of the fundamental elements of the business to move Ahead Together in pursuit of the company's strategy to deliver GSK's growth-based performance ambitions, oversee the demerger and listing of Haleon, establishing GSK as a pure biopharma business and drive our ESG leadership priorities. In doing so, these papers and presentations also highlighted the relevant stakeholder impacts and perspectives.

These materials enable the Board’s effective decision-making, input and oversight of business performance and governance.

The key items of business considered critical to GSK’s long-term success through the achievement of GSK’s key priorities are highlighted below:

<table><tr><td colspan="2">Areas of focus in 2022</td></tr><tr><td rowspan="5">Demerger and listing of Haleon</td><td>The Board&#x27;s preparation for the demerger as a value-based process included:</td></tr><tr><td>- discussing strategy and plans for Consumer Healthcare for the period up to and beyond its separation as Haleon</td></tr><tr><td>- receiving regular performance reports</td></tr><tr><td>- scrutinising and overseeing the Consumer Healthcare Capital Markets Day approach and materials</td></tr><tr><td>- supporting appointments to the Haleon Board, including the transition of Vindi Banga and Dame Vivienne Cox to Haleon</td></tr><tr><td rowspan="3">Build GSK as a pure biopharma business</td><td>- scrutinising and responding to an unsolicited proposal for the Consumer Healthcare business in advance of the demerger</td></tr><tr><td>- approving the GSK Shareholder Circular recommending the demerger and overseeing the Haleon Prospectus</td></tr><tr><td>- approval of the demerger and subsequent GSK share consolidation</td></tr><tr><td rowspan="5">Ahead Together - further strengthening the fundamentals of value creation</td><td>The Board&#x27;s oversight of the creation of GSK as a pure biopharma business and delivery of a step-change in performance included:</td></tr><tr><td>- regularly discussing and scrutinising transformation plans for GSK</td></tr><tr><td>- scrutinising updates on R&amp;D strategy, progress and progression of the company&#x27;s pipeline</td></tr><tr><td>- requesting the Remuneration Committee renew the Remuneration policy&#x27;s focus to incentivise overdelivery and reward a new performance culture</td></tr><tr><td>- Board and management succession planning, including approval of the appointment of a new Chief Scientific Officer, the transition of Dr Hal Barron to Non-Executive Director, and the appointment of two new independent Non-Executive Directors and a new Chief Financial Officer</td></tr><tr><td rowspan="2">Ahead Together - further strengthening the fundamentals of value creation</td><td>- approval of Charles Bancroft as successor to Vindi Banga in the role of Senior Independent Director</td></tr><tr><td>- approval of a change in approach to workforce engagement</td></tr><tr><td rowspan="5">Enhancing ESG leadership</td><td>The Board&#x27;s oversight of the fundamentals of commercial execution, cost base management, capital allocation, pipeline and culture included:</td></tr><tr><td>- setting and approving the Board&#x27;s 2022-24 priorities</td></tr><tr><td>- receiving regular progress updates and providing input into the company&#x27;s Vaccines mRNA strategy and plan</td></tr><tr><td>- receiving and discussing commercial strategy performance reports from Pharmaceuticals, Vaccines and ViV Healthcare</td></tr><tr><td>- receiving updates on R&amp;D strategy and pipeline progress</td></tr><tr><td rowspan="5">Enhancing ESG leadership</td><td>- approving business development transactions, acquisitions and strategic partnerships with third parties including: Sierra Oncology, Affinivax, Mersana Therapeutics, Spero Therapeutics, Wave Life Sciences and Tempus</td></tr><tr><td>- receiving quarterly reports from the CEO, CFO and CSO</td></tr><tr><td>- scrutinising the Group&#x27;s financial performance</td></tr><tr><td>- setting the company&#x27;s new name, purpose and simplified culture, through a new Code of Conduct</td></tr><tr><td>The Board&#x27;s oversight of our new culture and embedding ESG at our core:</td></tr><tr><td rowspan="5">Regular corporate governance oversight</td><td>- approving and supporting the new GSK culture</td></tr><tr><td>- approving the Responsible Business section of the Annual Report</td></tr><tr><td>- approving the Task Force on Climate-related Financial Disclosures section in the Annual Report</td></tr><tr><td>- final approval of our Pricing and Access Policy principles</td></tr><tr><td>- overseeing GSK&#x27;s overall response to the situation in Ukraine</td></tr><tr><td rowspan="10">Regular corporate governance oversight</td><td>The Board&#x27;s programme of governance included:</td></tr><tr><td>- reviewing the quarterly financial results, dividend proposals, earnings guidance, investor materials, results announcements and receiving reports from the external auditor</td></tr><tr><td>- approving the final 2021 Annual Report and Form 20-F</td></tr><tr><td>- setting the annual budget, and the forward-looking three-year plan</td></tr><tr><td>- conducting an annual review of the Board&#x27;s enterprise risk responsibility framework and enterprise-wide risks</td></tr><tr><td>- undertaking an annual Board evaluation and implementing its agreed outcomes</td></tr><tr><td>- reviewing and continuing to evolve the Board&#x27;s governance architecture</td></tr><tr><td>- evaluating the CEO&#x27;s 2021 performance, and setting her 2022 objectives</td></tr><tr><td>- reviewing the talent and succession plans annually</td></tr><tr><td>- receiving reports on Board committee work</td></tr><tr><td>- engaging with GSK&#x27;s stakeholders and the wider workforce to gather and understand their views on the company&#x27;s activities and operation</td></tr><tr><td>- reviewing the employee PULSE survey results</td></tr><tr><td>- receiving reports on wider corporate governance and regulatory developments, and the Company Secretary&#x27;s report</td></tr><tr><td>- approving the company&#x27;s modern slavery statement and gender pay gap positioning</td></tr><tr><td>- reviewing stakeholder perception research</td></tr></table>



## Ahead Together – Board oversight continued

## Board performance

The Board evaluates its performance, and that of its committees, every year. The evaluation is normally carried out externally every third year, with the last one being facilitated in 2020 by Jan Hall of No 4, a business advisory company which does not have any other connection with GSK. The Board felt it would be helpful for No 4 to conduct the 2022 evaluation following the completion of the demerger of Haleon and the formation of GSK as a new biopharma company.

## Preparation

No 4 met with the Chair and CEO in advance of the evaluation, for an update on how the Board is operating to understand GSK’s future priorities, and to agree the review’s objectives, scope and timetable. The Company Secretary also provided No 4 with access to Board and committee materials, and other information.

## Interviews

During November and December 2022, No 4 conducted confidential and detailed interviews with the Board, selected GLT members, the Company Secretary, GSK’s external auditor and our incoming and outgoing independent remuneration adviser, to seek their views on the Board’s effectiveness. These meetings reflected an agreed discussion guideline that was sent to each participant beforehand. This included key topics from the Financial Reporting Council’s 2018 Guidance on Board Effectiveness and the relevant requirements of its 2018 UK Corporate Governance Code. However, this did not limit the feedback each participant could give.

## Review

The Review sought to determine the Board’s priorities over the next three to five years and how they should be built into the Board’s agenda. The evaluation results and suggested next steps were included in a summary report, compiled by No 4 and discussed initially with the Chair, CEO and the Senior Independent Director (SID). The Review was presented to the Board in January 2023 which covered the following main areas of the effectiveness review:

– Overall review of the Board

– Board organisation, agenda and information

– Board dynamics, challenge and input

– Future strategy development

– Performance delivery

## Action points

After due consideration and discussion the following action points to further improve performance in 2023 were agreed:

– The key area of focus for the Board should continue to be R&D (organic and inorganic). Meeting the pipeline goals, and therefore delivering shareholder value, is seen by all as the top priority

– The importance of the Science Committee in working with the CSO to help optimise the pipeline

– Supporting the onboarding of the new CFO, Julie Brown

– Board succession planning would be progressed to ensure a broad range of diverse candidates for consideration as successor for the Remuneration Committee Chair

## Board committees

The review of the Board committees focused on their progress. It involved virtual interviews with committee members conducted by No 4 on behalf of the respective Committee Chairs. Each committee was considered to operate effectively and the following further enhancements were agreed:

– The importance of optimising concise feedback by Committee Chairs to the full Board following each committee meeting

– Following agreement of the overall Board priorities and the Board agenda, Committee Chairs agreed to review the main areas of responsibility for their committees in line with the Board priorities and incorporate them into their committee programmes for 2023

– In particular, the importance of the Science Committee in supporting organic and inorganic R&D and evolving the ways in which the committee works with the CSO and his team

## Chair

The SID and No 4 sought feedback on the Chair’s performance from the Directors individually and collectively. This concluded that the Chair was operating effectively in leading the Board. The results of the review were then noted by No 4 and discussed by the Chair and the SID.



# Key decisions and engagements

## Section 172 statement

Board members are required by law to promote the success of their organisation for the benefit of both shareholders and their wider stakeholders, including employees, suppliers and the community. This statement meets this requirement, as set out in Section 172 and Section 414CZA of the Companies Act 2006 (the Act). It states how, during the year, our Directors addressed the matters set out in Section 172(1) (a) to (f) of the Act when performing their duties.

The Board considers that the statement focuses on those risks and opportunities that are strategically important to GSK, and consistent with the Group’s size and complexity. This allows it to properly understand the potential impacts of the decisions it makes on all stakeholders.

Engagement with our main stakeholder groups, including our patients, shareholders, consumers, customers and employees at all levels and across the organisation, are summarised throughout the pages of our strategic report.
In particular, the Board’s continuous engagement with our investors and people is set out in this section on pages 114 to 116, and the company’s corporate governance architecture and processes are summarised on pages 107 to 109.

This summary sets out how the Board considered all relevant matters in making the principal decisions that contributed to the formation of two attractive and viable businesses with compelling investment propositions, through:

– delivering the separation of Haleon from GSK with a strong focus on shareholder value (the Demerger) and

– building GSK as a pure biopharma company that is ambitious for patients, accountable for impact and does the right thing (new GSK)

The Demerger represented a key step in a multi-year transformation of GSK to improve focus, performance and competitiveness, and to maximise value for shareholders. The Demerger also provided the right opportunity to implement the legal change of name of the company from GlaxoSmithKline plc to GSK plc. This was designed to mark the new GSK brand and culture and protect and build it for the future. The change was made in May 2022.

## (a) Long-term results

## The likely consequences of any decision in the long term

At the end of May 2022, the Board assessed the company’s readiness to proceed with the Demerger and approved the GSK Circular and agreed the Haleon Prospectus to be sent to shareholders as the final stage of the Demerger.

The Board exercised its Section 172 duties by reviewing the work of management and the Audit & Risk, Corporate Responsibility, Remuneration and Transformation & Separation committees in progressing the separation since mid-2020. This included:

– extensive consultations held with the key stakeholders, and sharing the long-term growth ambitions at the investor events for GSK in June 2021 and Haleon in February 2022

– considering and rejecting the unsolicited, conditional and non-binding proposals received to acquire the Consumer Healthcare business

In recommending these proposals to create two independent companies to most effectively serve their patients and customers respectively, the Board firmly believed that its decision would establish:
– a newly independent global leader in consumer health with a focused strategy to drive penetration growth across its portfolio, capitalising on new and emerging growth opportunities, underpinned by strong execution and financial discipline. Haleon, as an independent company, would be able to deliver sustainable above-market growth, moderate sustainable adjusted operating margin expansion in the medium term with attractive returns to shareholders

– new GSK, a pure biopharmaceuticals company with a portfolio focused on Vaccines, Specialty Medicines and General Medicines with clearly defined financial ambitions, a clear ambition to deliver large-scale and long-term positive human health impact and a strong balance sheet enabling a growth-oriented capital allocation policy and attractive shareholder returns

The Board believed that the Demerger would unlock the potential of both businesses, strengthen the balance sheet of new GSK and its ability to invest in growth and maximise long-term return for shareholders.

Shareholders duly approved the two resolutions proposed at the General Meeting held on 6 July 2022 and the Demerger was then effected on 18 July 2022.



## (b) Our workforce

## The interests of the Group’s employees

The Board had continual regard to the interests of our people who were either remaining with new GSK or departing to form Haleon. It achieved this by using various employee voice mechanisms described on pages 10, 11 and 115 to help explain the future shape of these companies, understand and assess the impact of these changes on the organisation and how they were being experienced by our people.

Significant focus was dedicated in bringing to life new GSK’s Ahead Together purpose, strategy and culture for our people across the Group. A strong emphasis has been given to individual ownership of our new culture. This was formally launched in June 2022 with events held around the company’s locations globally.

## (c) Our business relationships

The importance of developing the Group’s business relationships with suppliers, customers and others

A key imperative for the Board of GSK as a responsible business is to ensure the company develops and monitors these partnerships to ultimately serve patients. The benefits of these relationships and how they can support the achievement of our ambitions are described in the pages of our strategic report, for example:

– achieving our Ahead Together ambition to positively impact the health of 2.5 billion people by the end of 2030, requires the development of vaccines and medicines and making them available through responsible pricing, strategic access programmes and partnerships

## (d) The community and the environment

## The impact of the Group’s operations on the community and our environment

Our approach to making a positive impact has been guided by extensive stakeholder engagement on the key issues relevant to new GSK and, prior to the demerger, Haleon’s respective industries and the nature of the companies themselves. The Board has sought to achieve this by:

– in preparation for the Demerger, working with Haleon’s management team in developing its own distinctive responsible business approach and ESG framework bespoke to the needs of its customers and the communities it serves. This also involved scrutinising this framework and the proposed targets, including environmental sustainability targets. These were presented at Haleon’s investor update in February 2022
These were attended by GLT members and Non-Executive Board members including the Chair.

In 2022, in addition to our annual bonus and long-term incentive structure, the Board also gave a special thank you to all our people (excluding GLT), allowing us to recognise what we had achieved together in preparation for the Demerger and the transformation of the company into a pure biopharma company. As a result, everyone received a one-off payment equivalent to a week’s salary in March, separate to our 2021 bonus pay-out.

We also ensured that the treatment of awards or options held by GSK employees, and for departing Haleon employees, delivered a fair outcome in accordance with the rules of those share schemes as part of the Demerger and the GSK share consolidation.

– ethical behaviour is promoted across our business by supporting our people to do the right thing and working with suppliers that share our standards and operate in a responsible way. Our new Code of Conduct seeks to set out expectations in this regard

– our third parties are expected to meet our ABAC and labour rights standards and to comply with our standards on quality, health and safety, and the environment. Approximately 29% of our total emissions footprint comes from the goods and services that we buy. In September 2022, in support of our net zero carbon impact on climate ambition, we launched our Sustainable Procurement Programme. This will require our suppliers to, among other things, disclose emissions, set carbon reduction targets, and switch to renewable power and heat

– establishing the six areas of ESG focus for new GSK as a global biopharma company that are fundamental to our DNA and success. These six areas, detailed on pages 42 to 50, directly contribute to long-term shareholder value by contributing to our health impact, supporting thriving people and reducing risk. The environment is one of our principal ESG focus areas. In 2022, an environmental scorecard measure was introduced into our long-term incentive plans to incentivise and reward progress on delivering against our net zero impact on climate and net positive impact on nature public ambitions by 2030

The Board has also been focused on new GSK’s Ahead Together ambition to impact the lives of 2.5 billion patients over the next ten years. Human capital is key to GSK and as such we are seeking to strengthen early STEM education investments to further support a long-term diverse talent pool and increase the positive impact of volunteering activities within the communities in which we serve.



## Key decisions and engagements continued

## (e) Our reputation

Our desire to maintain our reputation for high standards of business conduct

This duty guided the Board’s approach to the Demerger and the creation of new GSK. This was achieved by:

– the transformation of the company, initially launched in early 2020. This included fundamentally reviewing our structure, cost base, ways of working and the effectiveness of both our biopharma and consumer healthcare businesses and implementing targeted enhancements in advance of the Demerger

– choosing the optimal form of separation through a Demerger with the same listing location and structure for Haleon as GSK. As a result, Haleon should operate to the same premium listed, legal and corporate governance standards, in an environment with common business and ethical values to GSK

– extensive legal and financial due diligence and engagement with key regulators, investors and other key stakeholders, which was undertaken in preparing the GSK Circular, the Haleon Prospectus and the Haleon 20-F

## (f) Fairness between our shareholders

Our aim to act fairly as between members of the Group

It was of fundamental importance that the Board was able to ensure that shareholders were treated fairly up to, on and after the Demerger. This was demonstrated by:

– deciding on the most appropriate capital structures required for the two companies to be competitive, on which stock exchanges Haleon should list, and whether, and to what extent, to distribute shares in Haleon to GSK’s shareholders and retain any stake in Haleon

– each shareholder having a right to vote on a one vote for one share basis at the General Meeting for the Demerger and the new GSK share consolidation, and related party transactions resolutions. To ensure that as many shareholders as possible could participate in the meeting, shareholders were able to ask questions and vote either electronically or in person. Voting majorities in excess of 99% were recorded for each resolution

## Approach to continuous engagement

Our stakeholders rightly have high expectations of us. The dynamic operating environment presents many challenges and opportunities. The Board aims to make sure that being commercially successful is balanced and aligned with meeting our stakeholders' expectations, upholding our reputation, maintaining our licence to operate and building trust. The Board engages with or is briefed on the views of our stakeholders, to ensure it identifies and responds to their expectations effectively and appropriately.

How we engage with our main stakeholder groups – including patients, shareholders, consumers, customers and employees – across the company is covered in the pages of our strategic report.
– reaching an agreement with the trustees of the GSK UK Pension Schemes on a package of measures (including funding and protections) in relation to the Demerger and the GSK UK Pension Schemes’ triennial actuarial valuations

– ensuring that GSK remained as one company in how we operated until the point of Demerger, with the overriding emphasis on driving top-line growth and improving margin

– implementing plans for the six areas of ESG focus for new GSK, outlined to investors in June 2021 to help retain and develop further GSK’s reputation for ESG leadership and responsible business conduct

– developing a distinctive and holistic responsible business case and ESG framework for Haleon which was outlined to investors in February 2022. This supported Haleon’s purpose, strategy and culture as a premium UK listed company, with a focus on the key responsible business issues

– ensuring that the Board and our people in new GSK commit annually to our new Code of Conduct introduced in June 2022. This Code sets out our Board endorsed Ahead Together purpose and culture, as well as the performance commitments our people make so we can all deliver on the company’s ambitions in the right way

– each shareholder receiving a pro-rated shareholding in Haleon after the Demerger, with the receipt of one Haleon share for each GSK share held. Additionally, all Haleon shares from the inception of the Demerger had equal rights to participate in capital, dividend and profit distributions by Haleon

– the GSK Share Consolidation achieved consistency in the GSK share price pre- and post-Demerger to enable comparability between the new GSK earnings per share and share price with previous periods. It also preserved, as far as reasonably possible, the value of share options and awards granted to our people after the Demerger

The Board placed two of our main stakeholders at the heart of our renewed culture, with our people all being ambitious for patients, accountable for impact, and doing the right thing. Our culture is described on pages 10 and 11 of the strategic report.

The influence and importance of different stakeholder groups can vary, depending on the matter being considered. Certain stakeholders’ interests can be in conflict, meaning the Board needs to make balanced judgements.

Continuous stakeholder engagement and feedback helps us identify emerging issues. It also enables the Board to make decisions in the context of what is relevant and important to each of them.



## Key decisions and engagements continued

Our principal Board committees, and the GLT, undertake engagement on the Board’s behalf in accordance with their remit. This means that they can build a detailed understanding of how our actions or plans are/or may impact stakeholders. These insights are then shared with the Board.

In particular, the Board receives briefings on stakeholders' perspectives from the work of the Corporate Responsibility Committee, which is discussed on pages 117 and 118.

Board members regularly receive:

– the CEO’s Board Report

– a specific External Stakeholders’ Report. This provides strategic insights based on an analysis of key developments, achievements and risks impacting our reputation and the perceptions of all our external stakeholders

– a regular Investor Relations Report which summarises investor perceptions

– regular corporate governance, litigation and regulatory updates

The Board also learns of stakeholder views through:

Engagement and feedback events such as: the quarterly investor results calls, the Annual General Meeting, employee survey reports, through the Board’s workforce engagement activities, and from experts presenting at Board or committee meetings. In addition to the Chair’s investor check-in meetings which he holds on an ongoing basis, our new SID, Charles Bancroft, joined him for some meetings. Charles also met individually with investors to introduced himself and gain a personal understanding of issues and any views they may have.

Other opportunities: Board members also gain wider stakeholder views during the annual strategy meeting with the GLT, as part of the annual review of strategy, budget and planning process. This includes a review of specific aspects of the company’s policies or strategy. In addition, Board members are encouraged to meet individually with employees, shareholders and other key stakeholders during their induction, and then on an ongoing basis. They are encouraged to report to the Board on such experiences where relevant and material.

## Our people

We have well-established and strong engagement mechanisms with our colleagues, which are described on pages 10 and 11 and are monitored regularly by the Board. Three key governance channels help communicate what our people are thinking to the Board:

– regular Board updates from our Chief People Officer and the CEO on culture and talent

– feedback from a range of pulse surveys of varying sizes of employee groups to help check sentiment and culture more quickly and frequently and provide valuable insights on the impact of major initiatives, events or communications

– direct engagement by the Board. Prior to the demerger, our designated Workforce Engagement Director, Dame Vivienne Cox, had a specific mandate to connect with our people
Workforce engagement: Dame Vivienne concluded her workforce engagement activities in the first half of the year. This was prior to her transfer to the Haleon Board in July 2022 on the separation of the Consumer Healthcare business. Her programme of visits was conducted on the same basis as she described in previous Annual Reports.

Dame Vivienne provided a focus for employee engagement as our designated Workforce Engagement Director from December 2018. Her tenure coincided in its entirety with the programme to transform GSK into a focused biopharma company and the demerger of Consumer Healthcare to form Haleon. She continued to take questions and gather feedback for the Board from employees on the future strategy, shape and culture of the two new independent companies in the build up to separation. In doing so, during 2022 she held listening events with a cross-section of:

– Consumer Healthcare employees in April 2022 prior to their transfer to Haleon and

– Digital and Tech employees in June 2022 that were helping to ensure a strong and secure technology platform for both companies

Prior to separation, the Board reviewed its formal workforce engagement arrangements. It was decided to move from a specific Workforce Engagement Director model and apply an 'alternative arrangement' to the three methods set out in the FRC's Code. Given that the new GSK Board was recently refreshed in terms of tenure, with over half of the independent Non-Executive Directors (NEDs) having served for less than three years, and with GSK's renewed purpose and focus as a global biopharma company, it was considered important to adopt a collective Board engagement model. This was agreed to be the most effective approach to ensure newer Board members meet our people and hear their views. This has been implemented by:

– a return to direct in-person receptions with local employees, following COVID-19 restrictions during Board site visits. During the second half of 2022 these included: Stevenage, UK (as one of our two global R&D hubs), Boston, US, and our Global HQ in Brentford

– the Chair undertaking a range of site visits, including: Raleigh Durham, US, to meet with our ViV employees, King's Cross, London where he met with our Artificial Intelligence and Machine Learning team, as well as our Respiratory supply chain employees based in Ware, UK and Aranda, Spain

– the Chair and Corporate Responsibility Committee Chair meeting with leaders of our employee resource groups (ERGs) to discuss how they experience GSK as well as hearing their views on progress with our diversity, equity and inclusion (DEI) agenda and ambitions

– utilising a variety of bespoke engagements that have enabled a broad and open dialogue and facilitated first hand engagement discussions between the NEDs and our people individually and as part of small groups, encompassing perspectives on our strategy, purpose and Ahead Together culture, and DEI



## Key decisions and engagements continued

## Our shareholders

The Board seeks to directly engage with and be directly accountable to institutional investors and private retail shareholders. It seeks to discharge this direct and continuous accountability in several ways. These include regular communications, the Annual General Meeting, General Meeting and our Annual Governance Meeting, and through the work of our Investor Relations team, the Chair, Sir Jonathan Symonds, and our Company Secretary, Victoria Whyte.

During the year, our CEO, Emma Walmsley, and CFO, Iain Mackay, gave quarterly results presentations to institutional investors, analysts and the media by webcast. They are also regularly joined by the CSO, the Chief Commercial Officer, and CEO, ViVi Healthcare and GSK Global Health. They are able to provide investors with more detailed insights into their specific areas of responsibility.

Through regular meetings, Emma and Iain have an ongoing and active dialogue with institutional shareholders about our performance, plans and objectives. In 2022 the CEO held a total of 92 engagements with major shareholders, representing approximately 40% of the company's share register. The CFO held a total of 113 such engagements with investors making up nearly 40% of the company's share register.

The Chair has always maintained a constant dialogue with shareholders too – including fund and portfolio managers – as well as engaging with governance and ESG professionals. During 2022 and up to the date of publication of this Report, the Chair held 27 meetings with a range of investors, who make up approximately 35% of the company’s share register. This enables him to gain a current understanding of investor views, insights and perspectives of the company. He discusses the many aspects of Board governance, oversight and succession.

Charles Bancroft was appointed our new SID in July 2022, after the demerger of the Consumer Healthcare business. He has been introducing himself to our shareholders to seek their views on GSK and discuss any key matters of importance. From his appointment as SID to the date of publication of this Report he had 14 meetings with investors making up over 25% of our share register.

The Chair, CEO and the rest of the Board had a particular focus in 2022 on communicating the final process for demerging Haleon, the ambitions for GSK as a global biopharma business beyond the demerger and progression of our pipeline over three key focus periods: to 2026, 2026 to 2031 and 2031 and beyond. They also sought investors feedback on our new Remuneration policy.

## Annual Governance Meeting

This year’s event was a hybrid meeting in central London. Institutional shareholders, key investment industry bodies and proxy advisory firms were invited. Over 14 institutional shareholders attended the event, representing approximately 25% of the company’s issued share capital. The Chair was joined by our new SID, Committee Chairs and GSK’s external audit partner and his successor.

We shared with investors the priorities and focus of the Board and its committees in 2022 and the progress made against them. This included:

– the execution of a clear plan for separation of Haleon from GSK with strong focus on shareholder value creation

– the creation of two attractive and viable businesses with compelling investment propositions

– building two highly-qualified Boards to complement the world class management teams

– re-architecting the GSK Board

– supporting the Haleon Board build

– the approval of a new binding Remuneration policy aligned to delivery of GSK’s public growth and ESG commitments announced at the Investor Update in June 2021 and

– continuous engagement with shareholders and other stakeholders

The meeting was well-received and shareholder feedback was shared subsequently with the full Board.

## Annual General Meeting

We were pleased to be able to hold a hybrid meeting at the Sofitel Heathrow in May 2022. This was the first meeting we were able to hold for in person attendance since the onset of the COVID-19 pandemic. We were pleased to see an increase in attendance by our shareholders compared to the 2021 AGM that had been held virtually at our registered office in Brentford. 94 shareholders joined the meeting in person and 68 shareholders joined virtually to watch or listen to updates from our Chair and the CEO, to ask questions, and vote. With the exception of our proposed Remuneration policy resolution which received shareholder approval of 62%, all our proposed resolutions were approved by shareholders, with majorities ranging from 91% to 99%.

Our AGM this year will be held once again in a hybrid format at the Sofitel Heathrow. Shareholders will also have the flexibility to be able to watch and listen, vote and ask questions at the meeting virtually via the Lumi platform and to ask questions via a video connection. See further details on page 299.

## General Meeting

In addition, the Board convened a General Meeting at Sofitel Heathrow on 6 July 2022 to seek shareholder approvals to authorise the demerger of Haleon and the related share consolidation for GSK. The Chair, CEO and CFO were present in person with the Company Secretary while the rest of the Board joined the meeting virtually. 46 shareholders joined the meeting in person and 99 shareholders joined virtually. Both resolutions were approved by shareholders with majorities in excess of 99%.



# Board committee reports

## Corporate Responsibility Committee report

## Dr Anne Beal

Corporate Responsibility Committee

I am pleased to present this report, which is my first as Chair of the Corporate Responsibility Committee (the Committee).

I joined the Committee in May 2021 and succeeded Lynn Elsenhans as Chair in July 2022 after a comprehensive transition and handover. During her time as Chair, Lynn made an outstanding contribution in overseeing, shaping and embedding our Trust priority and our approach as a responsible business, and, more recently, establishing the six areas of ESG focus for GSK as a pure biopharma company. These six areas – detailed on pages 42 to 50 – directly contribute to long-term shareholder value by contributing to our health impact, supporting thriving people and reducing risk.

I have been drawing on my extensive healthcare experience as a physician and public health expert – including my time as Chief Patient Officer of Sanofi combined with my passion for patient advocacy, to continue building on the Committee’s work. I have framed the work and scrutiny of the Committee on the following questions:

– how do we as a company and Committee know how we are performing across our ESG focus areas?

– can we challenge ourselves to further improve our performance?

– how we can best report to our key stakeholders on what we have done and the level of impact we have made?

## Driving the Board’s oversight for enhanced ESG performance

A central element of the Committee’s work over the last 12 months has been devoted to accelerating improvements in how ESG performance is understood and managed.

The Committee agreed the introduction and disclosure of a new ESG Performance Rating – one of our company KPIs as a key management tool to drive delivery of ESG across our six ESG focus areas. This rating has been derived from assessing the performance of a number of stretching, independently assured metrics across the focus areas to arrive at a single composite measure. The Committee has regularly monitored the company’s progress against these metrics during the course of the year. We recommended to the Board the publication of a final on track ESG Rating for 2022 alongside the other ESG disclosures in this Annual Report and our ESG Performance Report. Further details can be found on page 42 of the strategic report and within the ESG performance report, available on gsk.com.

## ESG performance deep dives

Throughout the year the Committee has discussed with management the following areas of our ESG focus.

Access and pricing principles: The Committee reviewed and recommended to the Board the adoption and publication of GSK’s Pricing and Access Principles (Principles).

The principles are a high-level articulation of management’s current approach to pricing and access. They have been prepared with extensive internal and external consultation and had been validated with key audiences including patient advocacy groups drawn from the US and UK.

The Committee, as part of its detailed input on these Principles, made sure that they captured:

– the impact value of GSK’s innovation in terms of economic benefit

– health equity within and between countries

– the importance of the supply network for access and

– that the Principles are sufficiently flexible to evolve over time and are subject to regular review

Diversity, Equity and Inclusion (DEI): The Committee continues to regularly assess the progress of GSK’s DEI approach and the key metrics identified to drive performance. Metrics to support some of these areas form part of the new ESG Performance Rating, which can be explored further on page 47.

This work includes efforts to further increase our leadership diversity, build a diverse talent pipeline and foster an inclusive culture. The Committee was pleased to note the strong overall progress that was being made towards the gender and ethnicity aspirations for 2025. In particular, it was pleased that the US ethnic diversity aspiration of at least 30% had already been exceeded this year, while further work was being undertaken to increase Black VP representation in the UK. I firmly believe that GSK is doing some outstanding work in this area and have been pleased with how the Committee’s feedback is being utilised by management to further improve performance for maximum impact.

The Committee also reviewed progress on efforts to broaden diversity of our clinical trial participants, grow our supplier diversity, improve health equity within countries and expand equitable access to STEM education.

Environment: The Committee has recently reviewed progress on the company’s ambition for net zero impact on climate and net positive impact on nature. The Committee is satisfied that good progress is being made to date, with a dual focus on maximising the success of the in-flight initiatives and developing targeted actions to maintain momentum against stretching ambitions.

Human rights: The Committee has reviewed management’s approach and progress on Human Rights including supply chain and third party interactions. We have also considered the complex and rapidly evolving legal and regulatory landscape for Human Rights.



## Board committee reports continued

ESG disclosures and reporting: GSK’s capability in respect of ESG reporting is continually evolving as we challenge ourselves on how best to report clearly and concisely on our performance. This is taking place against greater scrutiny on ESG from all stakeholders, with ESG reporting increasingly moving from voluntary to mandatory.

The Committee considers that GSK has a strong and mature ESG reporting approach, but there is an opportunity to bring the level of control of ESG data up to the same level as controls for financial data. With this in mind, the Committee has approved establishing an ESG data assurance hub to further strengthen ESG data oversight.

## Collaborating with other Board committees

There has been a careful division of responsibilities and allocation of the workload between this Committee and the Remuneration Committee, in respect of the introduction of specific ESG targets into our short- and long-term incentive plans from the beginning of 2022. We have been monitoring and helping the Remuneration Committee determine vesting outcomes.

The Audit & Risk Committee (ARC) supported the Committee in its discussions over the introduction, measurement and disclosure of the ESG Performance Rating. The Committee will also work closely with the ARC from this year onwards over the implementation and operation of enhanced ESG data assurance oversight and determinations, which the ARC Chair sets out further in his report on page 125.

## Dr Anne Beal

Corporate Responsibility Committee Chair
9 March 2023

## Science Committee report

## Dr Jesse Goodman

Science Committee

I am pleased to present this report as Chair of the Science Committee (the Committee) on our activities during 2022. It is the first since the demerger of Consumer Healthcare as Haleon in July 2022.

## Key activities in 2022

As a result of the demerger, GSK is now a pure biopharma business with a goal of uniting Science, Technology and Talent to better prevent and treat disease. In R&D, we are combining the power of genetic and genomic insights into what causes disease, with the speed and scale of Artificial Intelligence and Machine Learning to make better predictions about who a treatment might work for, and why.

This renewed focus has been evident in the Committee’s discussions for some time and I am excited for the future opportunities it brings for GSK and its patients. The Committee’s key activities in 2022 can be split into the following key areas, which are covered in more detail below:

– Pipeline reviews: monitoring of GSK’s pipeline

– Scientific deep-dives: discussion and analysis of the key scientific themes which drive the company’s R&D strategy

– Business development: undertaking technical reviews and assurance of the underlying science of potential business development transactions

## Pipeline progress

Fundamental to GSK’s achievement of its growth ambitions is the delivery of a successful pipeline, which the Committee has continued to monitor throughout the year.

During 2021, the Committee participated in the Chief Scientific Officer (CSO) succession planning process. This led to the appointment of Dr Tony Wood in August 2022. Dr Wood has since continued to build on the outstanding progress made by Dr Hal Barron. Prior to his appointment as CSO, Dr Wood was integrally involved in delivering R&D productivity improvement and helped develop GSK’s current R&D approach focused on the science of the immune system, human genetics and advanced technologies. Consequently, he was well-placed to implement a pipeline to deliver on GSK’s bold ambitions for patients.

An exceptional milestone during this year was the very positive results from our late-stage respiratory syncytial virus vaccine candidate. The vaccine demonstrated unprecedented efficacy in older adults and has the potential to help reduce disease and death from a major respiratory infection which has not, until now, been vaccine preventable. Our regulatory submission for the vaccine has been accepted for review in Japan, accepted by the European Medicines Agency under accelerated assessment and was submitted to and granted Priority Review status by the US Food and Drug Administration (FDA).



## Board committee reports continued

The Committee was also delighted with the positive phase III results for gepotidacin, a novel oral antibiotic, in the treatment of uncomplicated urinary tract infections. This is an important step in GSK’s continued scientific commitment and investment to address antimicrobial resistance (AMR).

Our licensing agreement with Spero Therapeutics (see below) provides further evidence of our continued leadership and focus in tackling infectious diseases and AMR.

A number of key approvals were also obtained during the year:

– FDA approval of Boostrix for immunisation during pregnancy for the prevention of whooping cough in newborn infants

– FDA approval of Menveo in a new single-vial presentation to help prevent disease caused by meningococcal bacteria serogroups A, C, Y and W

– FDA approval of Priorix for the prevention of measles, mumps and rubella in individuals 12 months of age and older

As well as having an exciting late-stage pipeline, we also now have a robust early-stage portfolio with a number of innovative programmes capable of transforming the lives of patients.

## Business development transactions

GSK is viewing research and development holistically and placing great importance on external as well as internal innovation to source promising new medicines and vaccines. During the year, the Committee continued to assess business development transactions from a scientific perspective. The acceleration of business development will be key to support GSK’s organic pipeline growth. Transactions reviewed by the Committee during the year include:

Sierra Oncology: The acquisition of Sierra Oncology, a biopharmaceutical company focused on targeted therapies for rare forms of cancer. The acquisition included mometolinib, a new medicine with a unique dual mechanism of action intended to address the critical unmet medical needs of myelofibrosis patients with anaemia. A new drug application for mometolinib for the treatment of myelofibrosis was accepted in August 2022 by the FDA and in December 2022 by the EMA.

Affinivax: The acquisition of Affinivax, a clinical-stage biopharmaceutical company, providing GSK with access to a next generation pneumococcal vaccine candidate and highly innovative Multiple Antigen Presenting System (MAPS) technology.

Mersana Therapeutics: The collaboration with Mersana Therapeutics for the co-development and commercialisation of XMT-2056, a first-in-class HER2 STING antibody drug conjugate, initially for the treatment of advanced breast cancer.
Spero Therapeutics: The licensing agreement with Spero Therapeutics for tebipenem HBr, a late-stage antibiotic that may treat complicated urinary tract infections. There is a significant unmet medical need for a novel oral antibiotic that can potentially provide an alternative to intravenous therapy, particularly for patients with multi-drug resistant organisms.

Wave Life Sciences: This collaboration brings together Wave's PRISM \( ^{™} \)  oligonucleotide platform and GSK's expertise in genetics and genomics to drive the discovery and development of oligonucleotide therapeutics focusing on novel genetic targets.

Tempus: The collaboration with Tempus provides GSK with access to Tempus' AI-enabled platform including its library of de-identified patient data – one of the world's largest sources of clinical and molecular data. Through its own leading AI/ML capability, GSK will work with Tempus both to identify new drug targets and improve clinical trial design, speeding up enrolment and completion, and accelerating the development of personalised treatments for patients.

GSK’s dedicated AI/ML team is the largest in-house strategic function in the biopharma industry. Collaborations between R&D and Technology within GSK have become increasingly important in drug discovery, enabling GSK to more rapidly and effectively design new vaccines and medicines.

## Scientific deep-dives

The Committee also dedicated a significant proportion of its time to discussing some of the most exciting and innovative areas of science which have been driving the company’s R&D strategy. Deep-dives undertaken during the year include:

– Phase 1 Pipeline review

– RNA based therapeutics and vaccines

– Oncology

In particular, the Committee’s discussion of RNA, including oligonucleotide therapeutics, provided important insights into emerging science with the potential to transform the lives of patients. In November 2022, the company published positive results from a phase IIb trial evaluating the safety and efficacy of bepirovirsen – a potentially transformative treatment for people living with chronic hepatitis B.

The results offer an early indication that bepirovirsen might be a potential treatment, either as monotherapy or in combination with other drugs, that could result in a functional cure. GSK’s expertise in human genetics, functional genomics and AI/ML to identify novel, genetically validated targets, as well as our recent collaboration with Wave Life Sciences referred to above, demonstrate that we are well-positioned to become a leader in oligo-based therapeutics.



## Board committee reports continued

## Committee changes

As previously mentioned, in August 2022 Dr Tony Wood succeeded Dr Hal Barron as CSO. Tony is an outstanding and highly respected scientist and the Committee had engaged with him regularly in advance of his appointment. Dr Barron transitioned to a Non-Executive Director and member of the Committee. The Committee, and GSK, will therefore continue to benefit from his expert advice and support on scientific matters.

Dr Laurie Glimcher retired from the Board in October 2022. I would like to thank Laurie for her valuable expertise and scientific insights contributed to the Committee during her tenure.

Finally, having chaired the Committee since its inception over six years ago, my rotation as Chair concluded effective 1 January 2023. Dr Hal Dietz, who joined the Committee on 1 January 2022, has succeeded me as Committee Chair. His experience in human genetics, which is central to GSK's approach in R&D, has already proven invaluable in the Committee's discussions. He is an excellent successor in the role of Chair.

It has been a privilege to work with GSK’s outstanding scientists and leaders, as well as my fellow Committee members, and to chair the Committee during what has been a transformational period, both for the company and the scientific fields in which we operate. I remain a member of the Committee and look forward to continuing the progress outlined today.

Dr Jesse Goodman
Science Committee Chair (2017-2022)
9 March 2023

## Nominations & Corporate Governance Committee report

Jonathan Symonds
Nominations & Corporate Governance Committee

I am pleased to present my fourth report as Chair of the Nominations & Corporate Governance Committee (the Committee).

## Key activities in 2022

During the year, the Committee continued its important role in the process of:

– delivering the demerger of Haleon from the Group as a key Board governance workstream and

– creating two attractive and viable businesses with compelling investment propositions, directed and overseen by highly capable boards

This was achieved in an orderly and targeted manner by building two highly-qualified boards to complement their world class leadership teams through:

– supporting the shaping and creation of the Haleon Board; and

– restructuring the GSK Board with a new focus and expertise for a pure biopharma business

## Haleon Board appointments

In my report last year, I described the work of the Committee in appointing the CEO, CFO and Chair designates of Haleon. I also disclosed that two Non-Executive members of the GSK Board were expected to transfer to the Haleon Board on completion of the demerger.

The Committee subsequently supported the Haleon Chair, Sir Dave Lewis, in finalising the search for and the appointment of high calibre non-executive directors to complete the Haleon Board and its committees. The Board subsequently endorsed the Committee’s recommendation to transition Vindi Banga and Dame Vivienne Cox to the Haleon Board on completion of the demerger. The Committee considered that the Haleon Board would benefit from both their knowledge and experience. They would also provide important continuity for Haleon post-demerger.

Separately, the company’s Consumer Healthcare joint venture partner (Pfizer) exercised its right to appoint two non-executive directors to the Haleon Board.

## Shaping our new biopharma Board

I previously described the process to transition the GSK Board as a pure focused global biopharma company and the work undertaken by the Committee in designing and planning the optimal structure and composition of the new biopharma Board.

## New Non-Executive Directors

The Committee wanted to ensure that new Non-Executive Director appointments would further deepen the biopharma skills, expertise and experience on the Board. A global search process was activated to appoint directors with deep life sciences commercial expertise and Artificial Intelligence and Machine Learning (AI/ML) expertise. A diverse list of such candidates was identified, shortlisted and then interviewed by Committee members, the CEO, CSO and our Chief People Officer.



## Board committee reports continued

Following careful review, the Committee was pleased to recommend the appointment of two high calibre individuals, Dr Vishal Sikka and Elizabeth McKee Anderson, as independent Non-Executive Directors with effect from 18 July and 1 September 2022, respectively.

Vishal has a very distinguished background as a world-leading technologist and most particularly in the field of AI/ML, which is not only central to GSK’s approach to R&D, but is also embraced across the Group. Meanwhile, Liz brings significant commercial understanding and experience in commercial biopharmaceuticals and is a seasoned biotech board member. Their contributions are already proving invaluable to the Board as a fully focused biopharma company.

Further details of Vishal and Liz’s experience and biographies can be found on pages 100 and 97. The rationale for their appointments was included in the company’s announcements on 4 May and 24 August 2022 respectively. They are available on gsk.com.

Dr Hal Dietz was appointed to the Board at the end of 2021, he joined the Board as a designated Scientific and Medical Expert on 1 January 2022. He has extensive experience in the field of human genetics, which is also central to GSK’s approach to R&D. The recruitment process for his appointment by the Committee was described in my report last year. After a year on the Board, Dr Dietz began his rotation as Science Committee Chair from 1 January 2023 in succession to Dr Jesse Goodman.

## Senior Independent Director (SID) succession

Vindi Banga performed the role of SID for over six years. Vindi's transition to the Haleon Board on completion of the demerger created the opportunity to appoint a successor. The Committee determined that Charles Bancroft, having served two years on the Board, with experience of working with investors from his role as CFO at Bristol Myers Squibb, a deep understanding of the pharma industry, his experience as a non-executive director of listed companies and having sufficient time to dedicate to the role, made him the ideal successor. He succeeded Vindi with effect from 18 July 2022. The Board fully endorsed his appointment.

## Continuing to shape the GSK Board for the future

## Management succession planning

I previously described the work of the Committee in the appointment of Dr Tony Wood as successor to Dr Hal Barron as CSO and a member of GLT. The transition of Drs Wood and Barron into the roles of CSO and Non-Independent Non-Executive Director took effect as planned on 1 August 2022.

## CFO succession

When our CFO, Iain Mackay, advised the Board of his intention to step down from the Board and leave the company, the Committee activated its CFO succession plan. A targeted search of high-quality executives for CFO succession had already been undertaken against a role profile for the next CFO for GSK as a pure biotech.
The Committee proposed, and the Board approved, the appointment of Ms Julie Brown as successor to Iain Mackay as CFO. Julie, currently Chief Operating and Financial Officer at Burberry Group plc, will join GSK in April 2023 and will work with Iain to transition his responsibilities. She will take on responsibilities as CFO and as an Executive Director on 1 May 2023. Our CFO succession process is described in more detail below.

In the Committee’s view, the ideal successor to Iain was a proven CFO of a global public company with deep biopharmaceutical experience. He or she would need to be an effective business partner to the CEO in the successful delivery of GSK’s growth ambitions. It was also important to the Committee that the successor be a good fit with our new culture and have a high energy and a positive mindset.

A thorough global search was initiated against this agreed profile. A shortlist of viable candidates was identified for the role. The CEO, other members of the Committee, the Chief People Officer and I met with Julie and there was unanimous support that she be recommended as Iain’s successor.

The Board is looking forward to welcoming Julie to GSK. She is a highly respected CFO with extensive experience in the biopharma and medtech sectors. Further details of Julie’s experience and the rationale for her appointment are included in the company’s announcement on 24 September 2022, which is available on gsk.com.

## GLT changes

In addition to the new CSO and CFO, the Committee has also reviewed the following internal senior executive changes to the GLT to help bring further simplification and alignment of the GLT in these areas:

– Luke Miels, Chief Commercial Officer, assumed full accountability for strategic commercial product development of vaccines, alongside his current accountabilities for strategic product development in Specialty and General Medicines and the commercial performance of the GSK portfolio in markets

– Regis Simard, President Global Supply Chain, assumed accountability for both Vaccines and Medicines supply

– Deborah Waterhouse, Chief Executive Officer ViiV Healthcare, assumed overall accountability for GSK Global Health

– Roger Connor, President of Vaccines and Global Health, left GSK to progress a new role in healthcare, outside biopharma

The Committee continues to review our talent and succession pipelines and development plans for key management roles and their successors.

## Non-Executive Director succession planning

The Committee regularly reviews the Board’s composition and skills. It will be working with the Science Committee for the potential to add a further Scientific and Medical Expert, as the Board seeks to further contribute to our biopharma skills and expertise to support our growth ambitions. The Committee is also looking to identify a successor to Urs Rohner, our Remuneration Committee Chair, who is due to retire from the Board in 2024.

I look forward to providing further updates on these roles next year.



## Board committee reports continued

## Composition and tenure



The Board seeks to balance its composition and tenure, and that of its committees, and to refresh them over time. This enables the Board to benefit from the experience of longer-serving Directors as well as the fresh perspectives and insights from newer appointees. Our Non-Executive Directors are now drawn from industries and backgrounds most relevant to a

## Diversity, equity and inclusion





pure biopharma company, including life sciences, the pharmaceuticals industry, R&D and Tech, vaccines and healthcare, medical research and academia and financial services. Collectively they have a wealth of experience of complex businesses with global reach.



1 Target female representation on Board is 40%. Data from GSK Annual Report published in the first quarter of each year. Current female representation is 27.2% at the date of publication. This is expected to rise to 36% in May 2023, post-CFO succession.

We are committed to the diversity of our Board, just as GSK is committed to equal opportunities for all employees at all levels of our organisation. The Board and management seek to encourage a diverse and inclusive culture throughout the company.

An effective Board needs a range and balance of skills, experience, knowledge, ethnicity, gender, social-economic backgrounds and independence, with individuals who are prepared to challenge each other collaboratively. This mix needs to be complemented by a diversity of personal Board attributes, including character, intellect, judgement, honesty and courage.

The Committee is responsible for developing measurable objectives and monitoring progress towards their achievement to assist the implementation of the Board’s diversity policy (Policy), including gender and ethnic diversity. As a minimum, we seek to align our Policy objectives with the Financial Conduct Authority, FTSE Women Leaders Review and Parker Review diversity targets and ensure that they are consistent with our public diversity, equity and inclusion (DEI) aspirations.

## Board and GLT gender diversity

<table><tr><td>Diversity objective</td><td>Status</td><td>Performance</td></tr><tr><td>At least 40% of Board positions held by women</td><td>Below objective</td><td>27.2%</td></tr><tr><td>At least one woman either in the Chair, SID role on the Board and/or one woman in the Chief Executive Officer or Finance Director role by the end of 2025</td><td>Met objective</td><td>One Director (CEO)</td></tr><tr><td>At least 40% of GLT positions held by women</td><td>Met objective</td><td>41.7%</td></tr><tr><td>At least one Board Director is ethnically diverse</td><td>Exceed objective</td><td>Two Directors</td></tr></table>



## Board committee reports continued

In May 2023, when Julie Brown becomes our new CFO, female Board representation will stand at 36%. GSK will then have one of the very few all-female Executive Boards running a FTSE 100 company. We also expect to fully restore our Board gender diversity to meet or exceed 40% by 2024.

The Board has been pleased that for many years its gender representation objective has been in excess of the target of over 40% of Board positions being held by women. This is illustrated on the previous page of my Committee report. The composition and diversity of the Board is currently in a transitional period following the demerger and the reshaping of the Board for the new biopharma company, the transfer of Board members to Haleon and the retirement of two female Board Directors. We also continue to oversee the developing pipeline of direct reports to the GLT by gender and from ethnically diverse backgrounds.

Details of GSK’s representation of women and ethnically diverse leaders is covered on page 47, as part of the diversity of our global workforce. Progress against our DEI commitments, including gender and ethnicity, is illustrated in our ESG Performance Report on gsk.com. This good progress has also been incentivised by the introduction of an ESG: DEI measure in the annual bonus arrangements for our Executive Directors and other GLT members.

Board committee and GLT membership and role changes in 2022

<table><tr><td>Director/GLT member</td><td>Membership/Role</td><td>Appointment date</td><td>Retirement date</td></tr><tr><td>Elizabeth McKee Anderson</td><td>Audit &amp; Risk and Remuneration committees</td><td>1 September</td><td></td></tr><tr><td>Dr Hal Barron</td><td>Science Committee (following transition to role of Non-Executive Director)</td><td>1 August</td><td></td></tr><tr><td rowspan="3">Charles Bancroft</td><td>Science Committee</td><td></td><td>8 February (stepped down after Dr Hal Dietz joined the Committee)</td></tr><tr><td>Senior Independent Director</td><td>18 July</td><td></td></tr><tr><td>Remuneration Committee</td><td>18 July</td><td></td></tr><tr><td>Vindi Banga</td><td>Audit &amp; Risk, Nominations &amp; Corporate Governance and Remuneration committees</td><td></td><td>18 July</td></tr><tr><td rowspan="3">Dr Anne Beal</td><td>Senior Independent Director</td><td>4 May</td><td></td></tr><tr><td>Nominations &amp; Corporate Governance and Remuneration committees</td><td>18 July</td><td></td></tr><tr><td>Audit &amp; Risk Committee</td><td></td><td>25 October</td></tr><tr><td>Dame Vivienne Cox</td><td>Corporate Responsibility and Remuneration committees</td><td></td><td>18 July</td></tr><tr><td>Dr Hal Dietz</td><td>Science Committee</td><td>1 January</td><td></td></tr><tr><td></td><td>Science Committee Chair</td><td>1 January 2023</td><td></td></tr><tr><td>Lynn Elsenhans</td><td>Corporate Responsibility Committee Chair</td><td></td><td>4 May</td></tr><tr><td></td><td>Audit &amp; Risk, Corporate Responsibility and Nominations &amp; Corporate Governance committees</td><td></td><td>18 July</td></tr><tr><td>Dr Jesse Goodman</td><td>Science Committee Chair</td><td></td><td>31 December</td></tr><tr><td>Dr Laurie Glimcher</td><td>Audit &amp; Risk and Science committees</td><td></td><td>10 October</td></tr><tr><td>Urs Rohner</td><td>Audit &amp; Risk Committee</td><td>18 July</td><td></td></tr><tr><td>Dr Vishal Sikka</td><td>Corporate Responsibility Committee</td><td>18 July</td><td></td></tr><tr><td>Roger Connor</td><td>President, Global Vaccines</td><td></td><td>1 December</td></tr><tr><td>Dr Tony Wood</td><td>Chief Scientific Officer and GLT member</td><td>1 August</td><td></td></tr></table>



## Board committee reports continued

## Ways of working

The Committee seeks to follow best practice in all the appointments it recommends, agreeing the criteria for each role, the most appropriate interview panel, before then considering a comprehensive and diverse long list of candidates. Shortlisted candidates are interviewed and assessed against the chosen criteria. Due diligence is then undertaken before the Committee makes its final recommendation. Executive search firms are appointed in accordance with the company’s procurement policy based on their expertise relative to each role.

The Committee has agreed that only search firms who are signatories to the Voluntary Code of Conduct of Executive Search Firms on gender diversity and best practice will be engaged.

The Committee worked with a number of executive search firms in 2022, who provided additional consultancy services to the company as outlined below:

– Korn Ferry: general recruitment, executive search and assessment services, coaching and other HR-related services

– Egon Zehnder: executive search, assessment and coaching services to specific senior executives

– Heidrick & Struggles: executive search services

The Committee reviewed the potential for conflicts of interest and judged that there were appropriate safeguards against such conflicts.

I look forward to reporting further progress in next year's report.

Sir Jonathan Symonds
Nominations & Corporate Governance Committee Chair
9 March 2023

## Audit & Risk Committee report

Charles Bancroft
Audit & Risk Committee

I am pleased to present this report, which is my second as Chair of the Audit & Risk Committee (the Committee).

In my report last year, I spoke about my initial, very favourable, impressions of the people, processes, systems and culture at GSK that underpin the successful management of financial reporting, audit, litigation and compliance risks. I am pleased to report that GSK continues to exhibit a strong compliance culture with a consistent tone and engagement from the top that runs throughout the organisation, and the financial reporting and controls framework remains robust and did not require any fundamental changes during the year.

## Key activities in 2022

Key decisions: As usual, it has been a busy year for the Committee. Not only working through its regular programme of activities, but making important decisions in support of the Board’s progression of its key priorities, in summary:

– recommended to the Board approval of the planned separation of our Consumer Healthcare business in July 2022, based on the Committee’s awareness and review of the transaction and Haleon’s operational readiness, and the approval of final issuance of public documents and entry into associated legal agreements

– exercised oversight for the Zantac product liability litigation by which I provided regular reports to the Board on progress

– conducted a robust review process, together with the CFO, to select and appoint a replacement to the current lead audit partner, who under the five-year audit partner rotation rules, rotates off after the publication of this Annual Report. Further details are set out on page 128

## Completion of the demerger

I highlighted, in my report last year, details of the technical work of the Committee as a key demerger governance workstream. This included overseeing the evolution of financial reporting matters, risk and controls and the public documents associated with delivering the demerger and listing to form Haleon. This work continued and intensified through the first half of 2022 to the point at which the Committee was able to complete its review processes and recommend the approval of the GSK Circular, Haleon Prospectus and Form 20-F and associated documents and matters to the Board. Separately, the Committee reviewed the processes to establish financial reporting systems and development of a robust internal control and risk management framework for Haleon. This was a significant and critical demerger workstream that was successfully delivered months prior to the demerger on a business-as-usual basis.



## Board committee reports continued

## Information and cyber security

This is one of our principal risks which is regularly on the Committee’s agenda. During 2022 the Committee oversaw the merging of programme deliverables into an updated Cyber Maturity Plan (CMP) with additional capabilities to continue to get ahead of a dynamic threat environment. The Committee has also reviewed the benchmarking of our target cyber maturity against an industry best-practice framework, known as the National Institute of Standards and Technology Cyber Security Framework (NIST-CSF) and these learnings have been incorporated into the CMP. The Committee will continue to perform regular assessments of delivery against the Plan to further enhance the capabilities and maturity of our cyber security framework. I am pleased that the Committee’s oversight in this area has been further strengthened this year with the expertise of my fellow Board Director colleague, Dr Vishal Sikka, who advises the Committee on this enterprise risk. Vishal has a distinguished career in the Tech industry and served as CEO of Infosys Limited and provides the Committee and management with valuable insights.

## Key risk indicators

For several years now, our Compliance function has worked with risk owners and management to develop and report to the Committee on key risk indicators (KRIs) at an enterprise level and across our markets. As a core part of this process, we have been using enhancements in our technology and data analytics capabilities to employ a more data-driven approach to risk management across a constantly evolving risk landscape to further strengthen our compliance oversight and culture.

Earlier this year, the Committee examined a review of our principal risks resulting in a simplified process with fewer KRIs, new KRIs, some revised definitions, and prioritisation of the most meaningful indicators for the company. The Committee was pleased to note that this simpler approach would result in more focus on fewer KRIs reported to Risk Oversight & Compliance Council (ROCC) which then reports to the Committee, with a greater focus being brought to bear on escalation of issues or concerns that are material to GSK. Meanwhile, operational data, monitoring findings and other established risks would continue to be analysed by risk owners to ensure appropriate risk mitigation continues and escalation, if necessary.

## Zantac litigation oversight

During the year, primary oversight for Zantac litigation, the related accounting, disclosure and communication assessments has continued to be undertaken by the Committee. I then report the Committee’s conclusions on these matters to the Board. The Committee continues to receive regular legally privileged updates. In December 2022, we welcomed the ruling by the United States District Court (Southern District of Florida) which dismissed all federal cases alleging the five remaining cancers in the Multi-District Litigation. We will continue to defend all claims brought at State level vigorously based on the science.

## Audit quality indicators

Audit Quality Indicators (AQIs) are quantitative and qualitative measures of external audit quality at an audit firm-level, an engagement level and from a management or company perspective. Together with our lead audit partner, I was pleased to participate in a project carried out by the FRC to identify the most useful engagement level AQIs relevant for the audit to help improve transparency and drive audit quality improvements. Our engagement with the FRC focused on our most recent Annual Report and considered the interactions between the auditor and the Committee during the audit process. We had a constructive dialogue and one which I hope was helpful to the FRC in progressing its work in promoting key drivers of audit quality.

## Committee aims in 2023

The Committee’s remit has expanded from 2023 onwards as the Board has requested that it exercise oversight and review of GSK’s ESG data assurance work. In doing so, the Committee is currently overseeing the build and implementation of a new dedicated ESG data assurance hub in our Finance organisation to support this.

The hub will ensure minimum standards of controls, governance and data quality to assure the accuracy of ESG data in support of the company’s performance against ESG metrics and compliance with new ESG reporting requirements. Meanwhile, our Corporate Responsibility Committee, on behalf of the Board, continues to exercise oversight of ESG strategy, performance assessment and reporting.

## Internal control framework

The Board recognises its obligation to present a fair, balanced and understandable assessment of GSK’s current position and prospects. Reflecting this responsibility, it is accountable for evaluating and approving the effectiveness of GSK’s internal controls, including financial, operational and compliance controls, and risk management processes.

We ensure the reliability of our financial reporting, and compliance with laws and regulations, through our internal control framework. This is a comprehensive enterprise-wide risk management model which supports the Board’s continuous identification, evaluation and management of the Group’s principal and emerging risks, as required by the FRC’s Code. The framework is designed to manage the risk of GSK not achieving its business objectives.

A fit-for-purpose framework – complemented by our corporate culture and Speak Up processes – ensures that the risks associated with our business activities are actively and effectively controlled in line with our agreed risk appetite. We believe GSK’s framework provides reasonable, but not absolute, assurance against material misstatement or loss.



## Board committee reports continued

The Board mandates the Group’s ROCC of senior leaders to assist the Committee in overseeing risk management and internal control activities. It also provides the business with a framework for risk management and upward escalation of significant risks. Risk Management and Compliance Boards (RMCBs) across the Group promote the ‘tone from the top’ and establish our risk culture, as well as ensuring effective oversight of internal controls and risk management processes.

Each principal risk has an assigned risk owner, drawn from senior management, who is accountable for managing the principal risk with oversight from a GLT member, which includes setting and implementing risk mitigation plans. Risk owners report quarterly on their respective risk management approach and progress at the ROCC and the appropriate Board Committee. Our Compliance function assists the ROCC and RMCBs. Compliance is responsible for advancing enterprise-wide risk management and for developing risk-based and ethically sound working practices. It also actively promotes ethical behaviours by enabling all employees to operate in line with our culture and comply with applicable laws and regulations.

Our Audit & Assurance (A&A) function provides independent assurance to senior management and the Board on the effectiveness of risk management Group-wide, in line with an agreed assurance plan. This helps senior management and the Board to meet their oversight and advisory responsibilities in fulfilling GSK’s strategic objectives and building trust with patients and other stakeholders. A&A has a dual reporting line to the CFO and the Committee.

The Committee receives regular reports from principal risk owners, Compliance and A&A on areas of significant risk to the Group and on related internal controls. These reports assess the internal control environment within each principal risk area, including enhancements to strengthen controls. Following consideration of these reports, the Committee reports annually to the Board on the effectiveness of GSK’s internal controls.
In 2022, through the authority delegated to the Committee, the Board conducted a robust assessment of the Group’s principal risks. This assessment, which was in line with the FRC’s Code, included consideration of the nature and extent of risk the Board is willing to take in achieving GSK’s strategic objectives.

The Board, via the Committee, also oversaw the effectiveness of our internal control environment and risk management processes across the Group for the whole year, up to the approval date of this Annual Report.

A review of the Group’s risk management approach is further discussed in the ‘Risk management’ section of the strategic report on pages 51 to 64.

The management of each principal risk is explained in ‘Principal risks and uncertainties’ on pages 285 to 295. The Group’s viability is discussed in the Group risk management section of the strategic report on page 64.

## Significant issues relating to the financial statements

In considering GSK’s quarterly financial results announcements and the financial results in the 2022 Annual Report, the Committee reviewed the significant issues and management judgements in determining those results. It reviewed management papers setting out the key areas of risk, actions taken to quantify the effects of the relevant issues, and judgements made by management on the appropriate accounting required to address those issues in the financial statements.

The significant issues considered in relation to the financial statements for the year ended 31 December 2022 are set out in the following table, with a summary of the financial outcomes where appropriate. The Committee and the external auditor have discussed the significant issues addressed by the Committee during the year and the areas of particular audit focus, as described in the Independent Auditor’s Report on pages 168 to 181.



## Board committee reports continued

<table><tr><td>Significant issues considered by the Committee in relation to the financial statements</td><td>How the issue was addressed by the Committee</td></tr><tr><td>Going concern basis for the preparation of the financial statements</td><td>The Committee considered the outcome of management&#x27;s half-yearly and year-end reviews of current and forecast net debt positions and the various financing facilities and options available to the Group. The Committee also considered management&#x27;s review of the impacts of the current economic environment and climate change impacts. Following consideration of these assessments, which included stress testing and viability scenarios, sources of liquidity and funding, forecasts and estimates, the Committee confirmed that the application of the going concern basis for the preparation of the financial statements continued to be appropriate.</td></tr><tr><td>Revenue recognition, including returns and rebates (RAR) accruals</td><td>The Committee reviewed management&#x27;s approach to the timing of recognition of revenue and accruals for customer returns and rebates. The RAR accrual for US Commercial Operations was £59 billion at 31 December 2022 and the Committee reviewed the basis on which the accrual had been made and concurred with management&#x27;s judgements on the amounts involved. A fuller description of the process operated in US Commercial Operations in determining the level of accrual necessary is set out in &#x27;Critical accounting policies&#x27; on pages 94 and 95.</td></tr><tr><td>Provisions for legal matters, including investigations into the Group&#x27;s commercial practices</td><td>The Committee received detailed reports on actual and potential litigation from both internal and external legal counsel including the Zantac litigation, together with a number of detailed updates on investigations into the Group&#x27;s commercial practices. Management outlined the levels of provision and corresponding disclosure considered necessary in respect of potential adverse litigation outcomes and also those areas where it was not yet possible to determine if a provision was necessary, or its amount. At 31 December 2022, the provision for legal matters was £0.2 billion, see Note 32 to the financial statements, &#x27;Other provisions&#x27; for more details.</td></tr><tr><td>Provisions for uncertain tax positions</td><td>The Committee considered current tax disputes and areas of potential risk and concurred with management&#x27;s judgement on the levels of tax contingencies required. At 31 December 2022, a tax payable liability of £0.6 billion, including provisions for uncertain tax positions, was recognised on the Group&#x27;s balance sheet.</td></tr><tr><td>Impairments of intangible assets</td><td>The Committee reviewed management&#x27;s process for reviewing and testing goodwill and other intangible assets for potential impairment. The Committee accepted management&#x27;s judgements on the intangible assets that required writing down and the resulting impairment charge of £402 million in 2022. See Note 20 to the financial statements, &#x27;Other intangible assets&#x27; for more details.</td></tr><tr><td>Valuation of contingent consideration in relation to ViiV Healthcare</td><td>The Committee considered management&#x27;s judgement that it was necessary to increase the liability to pay contingent consideration primarily as a result of updated exchange rate assumptions as well as increases in sales forecasts and the unwind of the discount. After cash payments of nearly £1.1 billion in the year, at 31 December 2022, the Groups&#x27; balance sheet included a contingent consideration liability of £59 billion in relation to ViiV Healthcare. See Note 33 to the financial statements, &#x27;Contingent consideration liabilities&#x27; for more details.</td></tr><tr><td>Viiv Healthcare put option</td><td>The Committee reviewed and agreed the accounting for the Pfizer put option and concurred with management&#x27;s judgement on the valuation of the put option of £1.1 billion at 31 December 2022.</td></tr><tr><td>Consumer Healthcare demerger</td><td>The Committee reviewed management&#x27;s process for presenting Consumer Healthcare as a discontinued operation and the subsequent demerger accounting. The gain on the demerger of £101 billion included significant values relating to the fair value of assets distributed and ownership in Haleon retained, the net assets and non-controlling interest distributed/de-recognised and the cumulative foreign exchange recycled. See Note 41 &#x27;Acquisitions and Disposals&#x27; to the financial statements for more details.</td></tr></table>



## Board committee reports continued

## Effectiveness and quality of external audit process

The Committee is committed to ensuring that GSK receives a high-quality and effective external audit. In evaluating Deloitte's performance during 2021, prior to making a recommendation on its reappointment in early 2022, the Committee reviewed the effectiveness of its performance against the criteria which it agreed with management at the beginning of 2021. The detailed criteria used for judging the effectiveness of Deloitte as external auditor are available on gsk.com. These are based on the audit approach and strategy, ensuring a high-quality independent audit, effective partnership and value for money.

The Committee monitors engagements with external stakeholders relevant to the Committee’s areas of oversight, including the FRC and Securities and Exchange Commission. During the year the FRC’s Audit Quality Review (AQR) team reviewed Deloitte’s audit of the Group’s 2021 financial statements as part of its annual inspection of audit firms. The Committee received and reviewed the final report from the AQR team which identified no key findings, assessed the audit as requiring limited improvement and noted several areas of good practice.

The Committee sought to ensure that Deloitte would deliver a smooth, thorough and efficiently-executed audit for 2022. In undertaking its review, the Committee considered:

– the overall quality of the audit

– the independence of Deloitte

– whether Deloitte exhibited an appropriate level of challenge and scepticism in its work

Deloitte’s length of tenure was not taken into account when assessing its independence and objectivity, given it only commenced its role as auditor in 2018. However, the Committee did consider how effectively it had assumed its role as auditor. The Committee also considered feedback on the 2022 external audit, through a survey of Committee members and the financial management team at corporate and business unit level. The survey covered the:

– effectiveness of the auditor’s challenge

– integrity of Deloitte

– transparency of its reporting to management and the Committee

– clarity of the auditor’s communications and ways of working

– alignment of the 2021 audit to the Group’s investment in Systems, Applications and Products (SAP)

– quality of the audit team’s leadership and

– skills and experience of the audit team

The Committee Chair regularly meets independently with the audit partners. The Committee also meets with the auditor privately at the end of each meeting to discuss progress, as appropriate. Having reviewed the above feedback, and noted any areas of improvement to be implemented by the audit team for 2023, the Committee was satisfied with the:

– effectiveness of the auditor and the external audit process and
– auditor’s independence, qualifications, objectivity, expertise and resources

The Committee therefore agreed to recommend the reappointment of Deloitte to the Board at the forthcoming AGM. In making its recommendation, the Committee was free from the influence of any third party.

## Auditor’s reappointment
External auditor

<table><tr><td colspan="2">External auditor appointment</td></tr><tr><td>Last tender</td><td>May - December 2016</td></tr><tr><td>Transition year</td><td>2017</td></tr><tr><td>First shareholder approval of current auditor</td><td>May 2018</td></tr><tr><td>First audited Annual Report and 20-F</td><td>Year ending 31 December 2018</td></tr><tr><td>New lead audit engagement partner</td><td>2023</td></tr><tr><td>Next audit tender required by regulations</td><td>2026 (to take effect from 2028)</td></tr></table>

There were no contractual or similar obligations restricting the Group’s choice of external auditor.

## Audit partner rotation

The external auditor is required to rotate the audit engagement partner for GSK every five years.

Our current audit partner is due to step down from their position after the audit of GSK’s financial statements for 2022 has been concluded.

After a robust review process by the Committee, together with the involvement of the CFO, to select their replacement, the Committee approved the appointment of the next audit engagement partner with effect from the financial year commencing on 1 January 2023.

The Committee is satisfied that Deloitte has been managing an orderly handover to the new audit engagement partner to ensure there is a seamless transition and maintenance of high levels of audit quality and effectiveness.

## Audit tender

The Committee considers that during 2022 the company complied with the mandatory audit processes and audit committee responsibility provisions of the Competition and Markets Authority Statutory Audit Services Order 2014.

As Deloitte continues to maintain its independence and objectivity, and the Committee remains satisfied with its performance, GSK does not intend to tender the external auditor contract before the end of the current required period of 10 years identified above and considers that this is in the best interests of shareholders. The Committee is mindful that the 2023 financial year will see a new CFO for GSK and audit partner for Deloitte, which will help further mitigate the risks of any over-familiarity between the company and the auditor.



## Board committee reports continued

## Non-audit services

Management operates on the presumption that other accountancy firms will provide non-audit services to GSK. However, where the external auditor's skills and experience make it the only suitable supplier of non-audit support – such as for audit-related matters, tax and other services – it may be used, in the best interests of the company. In line with GSK's non-audit services policy, the Committee ensures that auditor objectivity and independence are safeguarded by reviewing and pre-approving the external auditor's provision of such services. The company policy complies with the FRC's 2019 Revised Ethical Standard and the Sarbanes-Oxley Act of 2002. It observes the following core policy features on engaging the external auditor for non-audit services:

## GSK non-audit services policy, key features:

<table><tr><td>Process:</td><td>All non-audit services over £50,000 are put to competitive tender with other financial services providers, in line with the Group&#x27;s procurement process, unless the skills and experience of the external auditor make it the only suitable supplier.</td></tr><tr><td>Safeguards:</td><td>Adequate safeguards are established so that the objectivity and independence of the Group audit are not threatened or compromised.</td></tr><tr><td>Fee cap:</td><td>The total fee payable for non-audit services should not exceed 50% of the annual audit fee, except in special circumstances where there would be a clear advantage in the auditor undertaking the additional work.</td></tr><tr><td>Prohibitions:</td><td>GSK&#x27;s policy includes a &#x27;whitelist&#x27; of permitted non-audit services in line with the relevant regulations. Any service not on this list is prohibited.</td></tr><tr><td>Pre-approval:</td><td>All non-audit services require pre-approval as set out in the table below to ensure services approved are consistent with GSK&#x27;s non-audit policy for permissible services. This process ensures all services fall within the scope of services permitted and pre-approved by the Committee and does not represent a delegation of authority for pre-approval.</td></tr><tr><td></td><td>Value More than £50,000</td></tr><tr><td></td><td>Between £25,000 and £50,000</td></tr><tr><td></td><td>Under £25,000</td></tr><tr><td></td><td>Financial Controller</td></tr></table>

Audit and other services comparison (£m)



Audit and assurance services

● Other services, including tax, regulatory, compliance and treasury-related services

○ Services relating to the Consumer Healthcare demerger preparation

Note 8 to the financial statements provides further details of fees payable to the company’s auditor.
The fees paid to the company’s auditor and its associates are set out overleaf. Further details are given in Note 8 to the financial statements, ‘Operating profit’ on page 199.

During the year, fees for audit-related and other assurance services of £6.3 million included £4.4 million related to the continued work in the year associated with Deloitte's reporting accountant role in preparing for the demerger of the Consumer Healthcare business. Including audit fees in respect of the GSK pension schemes of £0.2 million, fees for audit-related and other assurance services represent 31.6% of the annual audit service fee (2021: 15.2%). Excluding the demerger work and quarterly review work, fees for audit-related and other assurance services would have represented 4.4% of the annual audit fee.

The Committee’s rationale for originally hiring Deloitte to undertake the reporting accountant role is set out on page 115 of GSK’s 2021 Annual Report.

The Committee considered the level of non-audit services incurred as part of its annual review of Deloitte’s independence set out on the previous page and was satisfied that the auditor continued to be independent and exercised objectivity throughout 2022.

## Fair, balanced and understandable assessment

The need for an annual report to be fair, balanced and understandable is one of the key compliance requirements for a company’s financial statements. To ensure that GSK’s Annual Report meets this requirement, we have a well-established and documented process governing the coordination and review of Group-wide contributions to the publication. This runs in parallel with the process followed by the external auditor. The Committee received a summary of management’s approach to GSK’s 2022 Annual Report to ensure it met the requirements of the FRC’s Code. This enabled the Committee, and the Board, to confirm that GSK’s 2022 Annual Report as a whole is fair, balanced and understandable and provides the necessary information for shareholders to assess the company’s position and performance, business model and strategy.

## Code of Conduct and reporting lines

We have a number of well-established policies (including a new Code of Conduct), which are available on gsk.com, together with details of our confidential Speak Up lines for reporting and investigating unlawful conduct.

Charles Bancroft
Audit & Risk Committee Chair
9 March 2023



## Directors' report

## Directors' powers

Our Directors’ powers are determined by UK legislation and our Articles of Association, which contain rules about the appointment and replacement of Directors. They provide that Directors may be appointed by an ordinary resolution of the members or by a resolution of the Board, provided that, if appointed by the Board, the Director retires at the next Annual General Meeting following their appointment.

Our Articles also provide that all Directors are required to seek re-election annually at the Annual General Meeting in accordance with the FRC’s Code.

A Director will cease to be a Director if he or she:

– becomes bankrupt

– ceases to be a Director by virtue of the Companies Act or the Articles

– suffers mental or physical ill health and the Board resolves that he or she shall cease to be a Director

– has missed Directors’ meetings for a continuous period of six months without permission and the Board resolves that he or she shall cease to be a Director

– is prohibited from being a Director by law

– resigns, or offers to resign and the Board accepts that offer

– is required to resign by the Board

## Directors' conflicts of interest

All Directors have a duty under the Companies Act 2006 to avoid a situation in which they have, or could have, a direct or indirect conflict of interest or possible conflict with the company. Our Articles provide a general power for the Board to authorise such conflicts.

The Board reviews any new potential or actual conflict, which is recorded by the Company Secretary. Directors are not counted in the quorum for the authorisation of their own actual or potential conflicts. The Nominations & Corporate Governance Committee reviews the Register of Conflicts on an annual basis which the Board subsequently approves.

On a continuing basis, the Directors are responsible for informing the Company Secretary of any such new actual or potential conflicts that may arise or if there are any changes in circumstances that may affect an authorisation previously given. Even when provided with authorisation, a Director is not absolved from his or her statutory duty to promote the success of the company. If an actual conflict arises post-authorisation, the Board may choose to exclude the Director from receipt of the relevant information and participation in the debate, or suspend the Director from the Board, or, as a last resort, require the Director to resign.
The Nominations & Corporate Governance Committee reviewed the register of potential conflict authorisations (the Register of Conflicts) in January 2022. The Committee reported to the Board that the conflicts had been appropriately authorised and that the process for authorisation continued to operate effectively. The Committee then recommended the approval of the Register of Conflicts to the Board which it subsequently approved. Except as described in Note 40 to the financial statements, 'Related party transactions', during or at the end of the financial year no Director or Person Closely Associated had any material interest in any contract of significance with a Group company.

Our Articles prohibit a Director from voting on any resolution concerning his or her appointment or the terms or termination of his or her appointment.

## Independent advice

The company has an agreed procedure for Directors to take independent legal and/or financial advice at the company’s expense where they deem it necessary.

## Indemnification of Directors

Qualifying third party indemnity provisions (as defined in the Companies Act 2006) are in force for the benefit of Directors and former Directors who held office during 2022 and up to the approval and signature of the Annual Report.

## Change of control and essential contracts

We do not have contracts or other arrangements which individually are fundamental to the ability of the business to operate effectively. Neither is the company party to any material agreements that would take effect, be altered, or terminate upon a change of control following a takeover bid. We do not have agreements with any Director that would provide compensation for loss of office or employment resulting from a takeover, except that provisions of the company’s share plans may cause options and awards granted under such plans to vest on a takeover.

Details of the termination provisions in the Executive Directors' service contracts are given in the full version of the company's 2022 Remuneration policy which is available on gsk.com in the Investors section.



## Directors' report continued

## Content of the Directors' report

For the purposes of the UK Companies Act 2006, the Directors' report of GSK plc for the year ended 31 December 2022 comprises:

## Directors' report

<table><tr><td>Section</td><td>Pages</td></tr><tr><td>Corporate governance report</td><td>96 to 131</td></tr><tr><td>Employee engagement</td><td>115</td></tr><tr><td>Directors&#x27; statements of responsibilities</td><td>166 and 167</td></tr><tr><td>Investor information</td><td>273 to 314</td></tr></table>

The strategic report sets out those matters required to be disclosed in the Directors' report which are considered to be of strategic importance:

## Strategic report

<table><tr><td>Section</td><td>Pages</td></tr><tr><td>Risk management objectives and policies</td><td>51 to 64 and 285 to 295</td></tr><tr><td>Likely future developments of the company</td><td>1 to 95</td></tr><tr><td>Research and development activities</td><td>15 to 28</td></tr><tr><td>Business relationships</td><td>49 and 50</td></tr><tr><td>Diversity</td><td>47</td></tr><tr><td>Provision of information to and consultations with employees</td><td>10, 11 and 47</td></tr><tr><td>Carbon emissions</td><td>45 and 46</td></tr><tr><td>Section 172 statement</td><td>112 to 114 and throughout 10 to 63</td></tr></table>

The following information is also incorporated into the Directors' report:

<table><tr><td></td><td>Location in Annual Report</td></tr><tr><td>Interest capitalised</td><td>Financial statements, Notes 17 and 20</td></tr><tr><td>Publication of unaudited financial information</td><td>Group financial review, page 65</td></tr><tr><td>Details of any long-term incentive schemes</td><td>Remuneration report</td></tr><tr><td>Waiver of emoluments by a Director</td><td>Not applicable</td></tr><tr><td>Waiver of future emoluments by a Director</td><td>Not applicable</td></tr><tr><td>Non pre-emptive issues of equity for cash</td><td>Not applicable</td></tr><tr><td>Non pre-emptive issues of equity for cash by any unlisted major subsidiary undertaking</td><td>Not applicable</td></tr><tr><td>Parent company participation in a placing by a listed subsidiary</td><td>Not applicable</td></tr><tr><td>Provision of services by a controlling shareholder</td><td>Not applicable</td></tr><tr><td>Shareholder waiver of dividends</td><td>Financial statements, Notes 16 and 45</td></tr><tr><td>Shareholder waiver of future dividends</td><td>Financial statements, Notes 16 and 44</td></tr><tr><td>Agreements with controlling shareholders</td><td>Not applicable</td></tr></table>

## The Directors' report

– has been drawn up and presented in accordance with and in reliance upon English company law and the liabilities of the Directors in connection with that Report shall be subject to the limitations and restrictions provided by such law.

– was approved by the Board of Directors on 9 March 2023 and signed on its behalf by:

Sir Jonathan Symonds
Chair
9 March 2023



## Remuneration

<table><tr><td colspan="2">In this section</td></tr><tr><td>Committee Chair&#x27;s annual statement</td><td>133</td></tr><tr><td>Annual report on remuneration</td><td>136</td></tr><tr><td>2022 Remuneration policy summary</td><td>158</td></tr></table>



# Remuneration report
Committee Chair’s annual statement

Dear Shareholder,

On behalf of the Remuneration Committee, I am pleased to present our Remuneration report for 2022. This includes my annual statement, explaining the Committee’s work this year, our annual report on remuneration for 2022, a summary of our Remuneration policy which was approved by shareholders at the 2022 AGM, and details of how we propose to operate the Policy this year.

## GSK's Remuneration policy 2022

As detailed last year, we introduced a new Remuneration policy in 2022 to better link executive remuneration to delivery of outperformance.

The new arrangements were designed to reward the delivery of the bold new performance ambitions set out at our Investor Update in 2021 – to deliver sales growth of more than 5% CAGR and adjusted operating profit growth of more than 10% CAGR from 2021 to 2026. These ambitions represent a step-change in performance for the Group and achievement of them should deliver top quartile performance for our sector.

The Committee concluded that the design of its existing Remuneration policy framework remained fit for purpose. However, given that driving long-term performance through consistent year-on-year improvement was the main aim behind these targets, changing the short-term Annual Bonus plan was determined to be the key imperative.

The main change to the plan was to significantly reduce the Annual Bonus opportunity for below-target performance while increasing the Annual Bonus opportunity for ‘exceptional performance’ to 300% of salary. The increase in overall Annual Bonus opportunity does not increase the cash reward opportunity, as any incremental reward is delivered in the form of shares deferred for three years.

The Committee is very aware of the sensitivity amongst stakeholders to levels of executive pay. We engaged extensively with shareholders to gain their views and feedback on these changes. Please see the table below which sets out the full details of this process.

As a result, we made adjustments to quantum, clarity on disclosure of outcomes, and transparency in relation to the targets set, that all feature in the final policy.

At the 2022 AGM, the new policy was approved with 62% of shareholders voting in favour, but the Committee recognises that a significant minority of shareholders voted against. Following the AGM, the Committee ensured continued consultation with shareholders to understand the full range of views, including those who voted against the proposals. The Committee thanks shareholders for their feedback and remains committed to engaging on remuneration. It continues to believe that incentivising outperformance against stretching targets will create long-term value for shareholders. Noting that no new issues were raised, the Committee is comfortable that no further change is required to the Annual Bonus plan. The Committee will review with shareholders the evolving needs of the business in advance of the renewal of our Remuneration policy in 2025.

Two administrative amendments to the 2022 Remuneration policy are being proposed for shareholder approval at the 2023 AGM. Further details are set out on page 163.

## 2022 remuneration outcomes

The very strong operating performance for GSK in the first year of the new remuneration arrangements has highlighted the importance of incentivising exceptional performance.

As set out earlier in the Annual Report, in 2022 the Group delivered strong sales growth of Vaccines and Specialty Medicines and double-digit growth in operating profit and earnings per share.

## 2022 Remuneration policy engagement

Details of the extensive consultation by the Committee and company Chairs regarding the 2022 Remuneration policy prior to the 2022 AGM vote and continuing engagement with shareholders afterwards, are set out below.

<table><tr><td>Engagement events</td><td>Dates</td><td>Investor participation</td><td>Share capital represented</td></tr><tr><td>Initial individual consultation meetings</td><td>October to November 2021</td><td>5 of the largest 15 shareholders</td><td>12%</td></tr><tr><td>2021 Annual Governance Meeting: invitations attendance</td><td>November 2021 December 2021</td><td>60 investors 13 investors</td><td>50% 15%</td></tr><tr><td>Follow-up letter after Annual Governance Meeting to non-attendees, setting out proposed Remuneration policy asking for input via meeting with the Remuneration Committee and company Chairs</td><td>January to February 2022</td><td>30 investors</td><td>35%</td></tr><tr><td>Letter circulated advising how feedback was incorporated into the final Remuneration policy to be submitted to the 2022 Annual General Meeting for binding approval</td><td>March 2022</td><td>40 investors</td><td>45%</td></tr><tr><td>Meetings held with shareholders prior to AGM</td><td>January to April 2022</td><td>11 investors</td><td>16%</td></tr><tr><td>2022 Annual Governance Meeting: invitations attendance</td><td>November 2022 December 2022</td><td>60 investors 14 investors</td><td>50% 25%</td></tr><tr><td>Meetings held after the AGM to the publication of this Annual Report</td><td>May 2022 to February 2023</td><td>20 meetings</td><td>35%</td></tr></table>

The principal proxy advisory firms were also consulted throughout the Remuneration policy process. This included invitations to the Annual Governance Meeting, receipt of engagement letters and meetings with the company and Remuneration Committee Chairs.



## Committee Chair’s annual statement continued

Remuneration awards for the year reflect this excellent operating performance, alongside successful delivery of the demerger of Consumer Healthcare to form Haleon, the largest demerger in Europe for over 20 years.

## 2022 Annual Bonus

The Bonus outcomes for the CEO and CFO were each determined by reference to performance against stretching total sales, adjusted operating profit and diversity, equity and inclusion (DEI) targets as well as the Committee’s assessment of their individual performance against specific strategic and operational measures.

The total sales growth rate was 3.4% above the target growth rate of 6.5% and the adjusted operating profit growth rate was 3.9% above the target growth rate of 12.8%. This led to an overall payout under the financial elements of 149.5% of salary. The targets were set with consideration given to analyst consensus, hence the Committee is comfortable that the payout represents exceptional performance. The full target range is set out on page 139. When combined with the assessment of the non-financial elements, the overall payout was 249.5% of salary for the CEO (149.5% of salary delivered in deferred shares) and 227.5% of salary for the CFO (127.5% of salary delivered in deferred shares).

The Committee believes the Bonus outcomes appropriately reflect the overall performance achieved in 2022. Full details are provided on page 139.

## Long-term incentive (LTI) awards

52% of the 2020 Performance Share Plan (PSP) award vested.

Targets were set against pipeline progress (20%), innovation sales (20%), adjusted free cash flow (30%) and relative TSR (30%). Disappointingly there was nil-vesting under relative TSR. However, strong performance against other metrics was evidenced with full vesting under the cash flow element and partial vesting under pipeline progress and innovation sales. This reflects progress in R&D, including positive data for the company’s potential new RSV vaccine, and strong sales from products launched over the last five years, including shingles vaccine Shingrix which generated sales of £3 billion during the year.

Following a review of contextual factors including previous payouts, the Committee believes that the formulaic outcomes appropriately reflect performance in the round having considered the experience of all stakeholders including shareholders and our employees. The Committee did not deem it necessary to exercise discretion. Incentive awards in relation to 2022 were made in accordance with the 2022 Remuneration policy.

## Remuneration policy implementation for 2023

## Annual Bonus and LTI performance measures

Following changes to the bonus in 2022, for 2023 we are maintaining the performance measures in our incentive plans as they continue to align with our strategic goals.

Annual Bonus measures will be: annual total sales growth (30%); annual adjusted operating profit growth (30%); personal performance against strategic and operational measures (30%); ESG: diversity, equity and inclusion (DEI) (10%).

LTI measures will be: relative TSR (30%), total sales growth over three years (20%); adjusted operating profit growth over three years (20%); pipeline progress (20%); and ESG: environment composite scorecard (10%).

## 2022 Pay for performance outcome



The nature of the strategic and operational objectives for each Executive Director will be in line with those agreed for the 2022 Annual Bonus. These focus particularly on individual areas of accountability to deliver the company’s strategy. For example, the CEO has clear pipeline delivery objectives. Each Executive’s objectives also require demonstration of their contribution to leading and living our culture of performance with integrity which the Board believes is a critical lever of long-term value creation for GSK.

The Committee has reflected at length on investor input regarding the most appropriate ESG measures to focus on. One theme which arose during consultation was the possibility of introducing a metric on access to medicines. However, as GSK is already an industry leader in this area, and as it is deeply engrained in the company’s culture and values, the Committee felt that it was not necessary to include this as a specific metric in incentives. Instead, the Committee has selected measures aimed at specific GSK challenges and opportunities in environmental sustainability and DEI.

Performance targets have been calibrated to consider a number of internal and external reference points, in particular analyst consensus has been considered for financial metrics where available. The Committee is therefore satisfied that the targets set for 2023 are sufficiently stretching.

## Salary

The Committee agreed that the CEO should receive a 4% salary increase for 2023 which is lower than the average increase to the wider workforce in the UK of 5%. In addition to the 5% average salary increase, the company has implemented a number of monetary and non-monetary initiatives for our colleagues in reaction to the cost of living crisis as explained in my statement.

## Workforce fairness

In setting executive pay it is important that the Committee does so with a good understanding of the Group’s wider workforce pay approach, with an emphasis on fairness and equity.

To that end, on an annual basis, I meet with senior Human Resources Leaders from across the company to understand perspectives on pay and GSK’s remuneration arrangements for the wider workforce. This year was the fourth such annual meeting held.



## Committee Chair’s annual statement continued

## How our performance measures align to our strategy

<table><tr><td>Performance measures</td><td>Alignment to strategy</td><td colspan="2">Weighting</td></tr><tr><td></td><td></td><td>AB</td><td>LT1</td></tr><tr><td>Total sales growth</td><td>Ambition of 5% sales growth</td><td>30%</td><td>20%</td></tr><tr><td>Adjusted operating profit growth</td><td>Ambition of 10% profit growth</td><td>30%</td><td>20%</td></tr><tr><td>Pipeline</td><td>Emphasis on Innovation - rewards acceleration and strengthening of pipeline</td><td>-</td><td>20%</td></tr><tr><td>Relative total shareholder return</td><td>Alignment with shareholders</td><td>-</td><td>30%</td></tr><tr><td>ESG ambitions</td><td>Nature and Climate ambitions 2022 - DEI Priorities</td><td>-</td><td>10%</td></tr><tr><td>Strategic and operational</td><td>Individual accountability for delivery of our strategy and public ambitions</td><td>30%</td><td>-</td></tr><tr><td></td><td></td><td>Key</td><td>Annual Bonus</td></tr></table>

At the meeting, we discussed how GSK continues to support its diversity aspiration through fair pay processes and proactive reviews and enhancements to its employee benefits. These included:

– new global minimum standards for parental leave and for care of a family member

– review of medical and insured benefits with a focus on equity for same sex couples wherever legally possible and

– new financial education support

Given the very challenging economic environment and cost of living pressures in many countries, management has taken action to support current employees and to attract talent, through competitive salary increases, one-off support payments to staff at lower grades, and enhancements to workforce wellbeing programmes.

At the start of 2022, changes were also made to the Annual Bonus plan below the GLT level to reflect a greater focus on performance. The new plan has been generally well received and first payments will be made in Q1 2023.

## Director changes

In August 2022, Dr Hal Barron transitioned, as planned, from his role as CSO to a non-independent Non-Executive Director. Dr Barron was contractually entitled to receive a pro-rated target bonus in respect of 2022. He did not receive an LTI grant in 2022.

We also announced the appointment of Julie Brown as CFO from May 2023, when Iain Mackay will step down from the Board. As previously communicated, Mr Mackay will continue to receive his base salary until he leaves GSK at the end of the year and will be eligible to receive an Annual Bonus in respect of 2023. He will not be eligible to receive any further LTI awards and will receive no salary increase in 2023. Full details of his retirement arrangements including the treatment of in-flight LTI awards can be found on page 149.
Our new CFO, Julie Brown’s salary of £915,335 was preliminarily set in line with that of her predecessor in September 2022. Her salary upon joining has been increased by 4% to £951,948. This is in line with the increase agreed for the CEO and is below that which has been awarded to the UK wider workforce.

## AGM

Finally, I would like to again thank shareholders for their valued input and engagement. I welcome all further feedback and look forward to receiving your support for this report at our Annual General Meeting on 3 May 2023.

Urs Rohner
Remuneration Committee Chair
9 March 2023

## Consideration of potential windfall gains

The Committee is aware of the guidance from investor bodies around considering a potential executive benefit arising from share award grants around the time of the stock market fall at the onset of the COVID-19 pandemic in March 2020.

Our Remuneration Policy contains sufficient flexibility to reduce the vesting of awards if required.

However, the Committee determined that no reduction is required in respect of the awards granted in March 2020. In making this determination, the Committee considered the share price at the following points:

– The share price at the time of the February 2020 award of £16.81

– The share price over the final quarter of 2022 of £13.99

– The share price at the time of the March 2019 award (grant previous to the 2020 award) of £15.09

Whilst there have been upward and downward movements in GSK’s share price over the period, taking these above points into consideration the Committee was satisfied that there was no risk of windfall gains.



## Annual report on remuneration

## 2022 Total remuneration (audited)



## 2022 Total remuneration (audited)

<table><tr><td rowspan="2"></td><td colspan="3">Emma Walmsley, CEO</td><td colspan="3">Iain Mackay, CFO</td><td colspan="2">Dr Hal Barron, former CSO (to 31 July 2022) \( ^{2)} \)</td></tr><tr><td>2022 £000</td><td>2021 £000</td><td>2022 £000</td><td>2021 £000</td><td>2022 £000</td><td></td><td>2022 $000</td><td>2021 $000</td></tr><tr><td>Fixed pay</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Salary</td><td>1,260</td><td>1,223</td><td>915</td><td>889</td><td>1,332</td><td>1,883</td><td></td><td></td></tr><tr><td>Benefits</td><td>131</td><td>134</td><td>291</td><td>242</td><td>107</td><td>145</td><td></td><td></td></tr><tr><td>Pension</td><td>253</td><td>245</td><td>183</td><td>178</td><td>190</td><td>651</td><td></td><td></td></tr><tr><td>Total fixed pay</td><td>1,644</td><td>1,602</td><td>1,389</td><td>1,309</td><td>1,629</td><td>2,679</td><td></td><td></td></tr><tr><td>Pay for performance</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Annual bonus \( ^{(1)} \)</td><td>3,143</td><td>2,275</td><td>2,082</td><td>1,573</td><td>1,177</td><td>3,483</td><td></td><td></td></tr><tr><td>Vesting of PSP LTI awards \( ^{(3)(4)} \)</td><td>3,666</td><td>4,326</td><td>1,854</td><td>2,408</td><td>4,381</td><td>6,371</td><td></td><td></td></tr><tr><td>Total pay for performance \( ^{(5)} \)</td><td>6,809</td><td>6,601</td><td>3,936</td><td>3,981</td><td>5,558</td><td>9,854</td><td></td><td></td></tr><tr><td>Total remuneration</td><td>£8,453</td><td>£8,203</td><td>£5,325</td><td>£5,290</td><td>$7,187</td><td>$12,533</td><td></td><td></td></tr></table>

## Notes:

(1) The mandatory Deferred Annual Bonus Plan (DABP) bonus deferrals for 2022 and 2023 are set out on page 154. The payment shown for Dr Barron represents a pro-rated on-target payment in respect of 1 January 2022 to 31 July 2022, in lieu of an Annual Bonus opportunity.

(2) Dr Barron transitioned from his role as CSO to Non-Executive Director on 1 August 2022. Salary above includes the basic salary earned for his time as CSO from 1 January to 31 July 2022 plus payment in lieu of accrued holiday not taken, in accordance with GSK's standard all employee US holiday pay policy. His Non-Executive Director fees earned from 1 August to 31 December 2022 were $17,107. Please see page 153 for further details.

(3) The PSP vesting figure for the CEO is inclusive of a top-up award (25% of salary) made in May 2020 following the vote in favour of the Remuneration policy at the company's 2020 AGM. This award will not vest until May 2023 and the final actual value received for the 2020-22 PSP will be restated in the 2023 Annual Report.

(4) The 2020 PSP was valued based on the vesting prices on 10 February 2023 of £14.78 and the ADS price of $35.727. The share and ADS prices on 14 February 2020, the main date of grant were £16.686 and $43.74. In respect of the top-up award for the CEO, the share price was £16.814. Of the vested amounts for the Executive Directors, nothing was attributable to share price appreciation over the performance period. The Committee did not exercise any discretion in relation to the vesting of the awards or share price changes. The value for Dr Hal Barron is illustrative as the award will not vest until August 2023 in accordance with the terms of the Executive and Senior Management Recoupment Policy. The actual value received will be restated in the 2023 Annual Report.

(5) The Committee may in specific circumstances, and in line with stated principles, apply malus/clawback, as it determines appropriate. Following due consideration by the Committee, there has been no recovery of sums paid (clawback) or reduction of outstanding awards or vesting levels (malus) applied during 2022 in respect of any of the CEO, CFO or the former CSO.



## Annual report on remuneration continued

## 2022 Total remuneration (audited) continued

The following sections provide details of each element of 2022 'Total remuneration', and how the Committee implemented the company's shareholder-approved Remuneration policy during the year in terms of fixed and performance pay:

## Fixed pay (audited)

## Salary

The table below sets out the base salaries of the Executive Directors over the last two years compared to increases for the UK and US workforce.

<table><tr><td></td><td>2022 effective date</td><td>% change</td><td>2022</td><td>Salary</td></tr><tr><td>UK &amp; US employees</td><td>1 April</td><td>3%</td><td>-</td><td>-</td></tr><tr><td>Emma Walmsley</td><td></td><td></td><td>£1,259,855</td><td>£1,223,160</td></tr><tr><td>Iain Mackay</td><td>1 January</td><td>3%</td><td>£915,335</td><td>£888,675</td></tr><tr><td>Dr Hal Barron \( ^{(1)} \)</td><td></td><td></td><td>$2,026,549</td><td>$1,967,523</td></tr></table>

(1) With effect from 1 August 2022, Dr Barron transitioned to a Non-Executive Director role and has not received a salary since that date. He receives Non-Executive Director fees as described on page 153. Dr Barron's 2021 base salary was increased by 8% from $1,821,781 to $1,967,523 with effect from 1 August 2021. See page 126 of the 2021 Annual Report for further details.

Details of salary levels for 2023 are provided on page 147.

## Benefits

The UK remuneration reporting regulations require the company to add into each Executive Director’s total benefits all items which are deemed by tax authorities to be a taxable benefit for them.

These comprise:

– Employee benefits in line with the policy for other employees, which may vary by location and role

– Business-related services provided to employees to assist or enable them to carry out their role, which a tax authority has deemed to be a taxable “benefit” to the individual. Because these are business expenses, the company meets the tax which arises on them and therefore the items are shown grossed up for tax. These include business travel and other related business costs
The table below provides an analysis of Total benefits (grossed up for tax) received by the Executive Directors in 2022 and 2021.

<table><tr><td></td><td>2022 Benefits £000</td><td>2021 Benefits £000</td></tr><tr><td>Emma Walmsley</td><td></td><td></td></tr><tr><td>Benefits available to employees</td><td>66</td><td>71</td></tr><tr><td>Business-related services</td><td>65</td><td>63</td></tr><tr><td>Total benefits</td><td>131</td><td>134</td></tr><tr><td>Iain Mackay</td><td></td><td></td></tr><tr><td>Benefits available to employees</td><td>156</td><td>131</td></tr><tr><td>Business-related services</td><td>135</td><td>111</td></tr><tr><td>Total benefits</td><td>291</td><td>242</td></tr><tr><td>Dr Hal Barron</td><td>$000</td><td>$000</td></tr><tr><td>Benefits available to employees</td><td>71</td><td>83</td></tr><tr><td>Business-related services</td><td>36</td><td>64</td></tr><tr><td>Accommodation whilst on business travel \( ^{(1)} \)</td><td>-</td><td>(2)</td></tr><tr><td>Total benefits</td><td>107</td><td>145</td></tr></table>

Notes:

(1) 2021 represents one-off refund of accommodation costs relating to 2020.



## Annual report on remuneration continued

Fixed pay (audited) continued

## Pensions

From 1 January 2023, pension arrangements for Executive Directors were aligned to the wider workforce. Further details are given on page 147.

<table><tr><td>Executive Director</td><td>Member since</td><td>Pension arrangements in 2022</td></tr><tr><td>Emma Walmsley</td><td>2010</td><td>Pension contributions of 20% of base salary and matching contributions of up to 5% on the first £13,333 of salary, with a cash payment of 20% of base salary in lieu of pension on salary in excess of £13,333 in line with plan rates.</td></tr><tr><td>Iain Mackay</td><td>2019</td><td>Member of the 401(k) plan open to all US employees and the Executive Supplemental Savings Plan (ESSP), a savings scheme open to US executives to accrue benefits above the 401(k) plan limits.</td></tr><tr><td>Dr Hal Barron</td><td>2018-July 2022</td><td>He received 38% of base salary, less a contribution to the 401(k) and ESSP equivalent to 5% of total base salary and bonus (net of the bonus deferred under the DABP). In addition, in line with the wider US workforce, from 1 January 2021, a combined contribution rate under the 401(k) and ESSP plans of 11% (7% core contribution plus a match of up to 4%) of total base salary and bonus (net of the bonus deferred under the DABP).</td></tr></table>

The following table shows the breakdown of the pension values included in Total remuneration on page 136. They are calculated in accordance with the methodology set out in the UK Large and Medium-sized Companies and Groups (Accounts and Reports) Regulations 2008 (as amended) (Remuneration regulations).

<table><tr><td></td><td colspan="3">Emma Walmsley</td><td colspan="3">Iain Mackay</td><td colspan="2">Dr Hal Barron</td></tr><tr><td>Pension remuneration values</td><td>2022 £000</td><td>2021 £000</td><td>2021 £000</td><td>2022 £000</td><td>2021 £000</td><td>Jan-Jul 2022 $000</td><td>2021 $000</td><td></td></tr><tr><td>UK defined contribution</td><td>3</td><td>3</td><td>3</td><td>3</td><td>-</td><td>-</td><td>-</td><td></td></tr><tr><td>US defined benefit</td><td>-</td><td>-</td><td>-</td><td>-</td><td>(134)</td><td>350</td><td></td><td></td></tr><tr><td>Employer cash contributions</td><td>250</td><td>242</td><td>180</td><td>175</td><td>324</td><td>301</td><td></td><td></td></tr><tr><td>Total pension remuneration value</td><td>253</td><td>245</td><td>183</td><td>178</td><td>190</td><td>651</td><td></td><td></td></tr></table>

Dr Hal Barron is now a deferred member of the US style defined benefit plan. Further details regarding the 2022 pension values for Dr Barron are set out in the table below. His accrued benefit (ie the annual pension accrued to date) for 2022 was calculated as the increase in the accrued benefit, adjusted for inflation and multiplied by 20 to reflect the fact that the benefit will be received over a number of years. The normal retirement age under the Cash Balance Pension Plan is age 65. Dr Barron has not received any additional benefit for retiring early.

<table><tr><td></td><td colspan="2">Accrued pension</td><td rowspan="2">Pension remuneration value for 2022 $000</td></tr><tr><td>Dr Hal Barron pension values</td><td>31 July 2022 $000</td><td>31 December 2021 $000</td></tr><tr><td>US - Funded</td><td>2</td><td>2</td><td>(6)</td></tr><tr><td>US - Unfunded</td><td>194</td><td>187</td><td>(128)</td></tr><tr><td>Total</td><td>196</td><td>189</td><td>(134)</td></tr></table>



## Pay for performance (audited)

Annual Bonus



## 2022 Annual Bonus performance against measures

The following table shows the Annual Bonuses earned compared to the bonus opportunity for 2022:

<table><tr><td rowspan="2">Bonus</td><td colspan="4">2022 Bonus opportunity</td><td colspan="6">2022 Bonus outcome</td></tr><tr><td>Target (% of salary)</td><td>Maximum (% of salary)</td><td>2022 salary</td><td>Total sales growth (% of salary)</td><td>Adjusted operating profit growth (% of salary)</td><td>Strategic and operational measures (% of salary)</td><td>ESG (% of salary)</td><td>Total 2022 bonus (% of salary)</td><td>Total 2022 bonus</td><td></td></tr><tr><td>Emma Walmsley</td><td rowspan="2">100</td><td rowspan="2">300</td><td>£1,259,855</td><td rowspan="2">71</td><td rowspan="2">79</td><td>90</td><td>10</td><td>249.5</td><td>£3,143,340</td><td></td></tr><tr><td>Iain Mackay</td><td>£915,335</td><td>78</td><td>0</td><td>227.5</td><td>£2,082,390</td><td></td></tr></table>

Details of the mandatory deferral by Executive Directors into the DABP for the 2022 bonus are set out on page 147.

Dr Barron received a pro-rated ‘on-target’ payment for 2022 of $1,177,064 in lieu of a bonus opportunity. This is because he transitioned to a Non-Executive Director role on 1 August 2022. This contractual payment, in accordance with the company’s Remuneration policy, is included in his remuneration for 2022 under Annual Bonus in the table on page 136.

## 2022 financial performance measures

<table><tr><td></td><td></td><td></td><td colspan="3">2022 Performance</td></tr><tr><td></td><td>Target weighting</td><td>Target growth rate</td><td>Outcome growth rate</td><td>Positioning achieved</td><td></td></tr><tr><td>Total sales growth</td><td>30%</td><td>6.5%</td><td>9.9%</td><td>+3.4%</td><td></td></tr><tr><td>Adjusted operating profit growth</td><td>30%</td><td>12.8%</td><td>16.8%</td><td>+3.9%</td><td></td></tr></table>

These targets were set following consideration of analyst consensus as well as internal budgets. The annual targets for 2022 exceeded the long-term sales and profit targets stated in our Investor Update of 5% and 10% respectively. The Committee is therefore comfortable that over achievement of these represents exceptional performance. Threshold and maximum performance targets were set at 1% below and 5% above target growth respectively. The total sales and adjusted operating profit targets and outcomes for the purposes of the Annual Bonus calculation are based on CER and exclude the commercial benefit from COVID-19 solutions.

## Overview of performance against financial performance measures

– 2022 saw a step-change in commercial execution; earnings guidance was updated during the year as momentum grew. This was driven by strong sales growth across Specialty Medicines and Vaccines, exceeding guidance for sales and operating profit

– Delivered full-year reported Group sales of £29.3 billion (+19% AER, +13% CER) with Specialty growth of 37% AER, 29% CER with double-digit growth across all Specialty therapy areas and Vaccines growth of 17% AER, 11% with a record year for Shingrix. The outcome was adjusted to exclude the benefit from COVID-19 solutions

– Adjusted Group operating profit of £8,151 million above target, driven by higher sales supported by prioritised investment and effective cost control. The outcome was adjusted to exclude the commercial benefit from COVID-19 solutions

– Adjusted EPS of 139.7p (+27% AER, +15% CER) was ahead of guidance excluding COVID-19 solutions



## Annual report on remuneration continued

## Pay for performance (audited) continued

## 2022 strategic and operational measures performance

The Committee received and considered a performance assessment report for each Executive Director showing the extent of their achievement against the individual personal strategic and operational measures agreed by the Committee for them to support the delivery of our strategic commitments during 2022. The Committee also reviewed Dr Hal Barron's performance in July 2022 before the release of his contractual 'on-target' bonus payment.

As with the financial elements of the Annual Bonus, the Committee was satisfied that the scale of Executive Directors' achievements this year was of an exceptional nature. In particular, these achievements relate to the pipeline, commercial execution and Haleon demerger.

<table><tr><td colspan="2">Strategic and operational measures Performance achieved</td></tr><tr><td colspan="2">Emma Walmsley</td></tr><tr><td colspan="2">The Committee determined that the CEO clearly exceeded or met her individual objectives</td></tr><tr><td>Strengthen pipeline and build GSK&#x27;s reputation for Innovation</td><td>- 47 potential new medicines and 22 vaccine candidates in development, with 18 now in phase 3/registration. Two-thirds of pipeline now focused on infectious diseases
- Significant progress to strengthen pipeline and advance key assets (including RSV OA vaccine, bepiovirsen, gepotidican, daprodustat and depemokinab) more than offset termination decisions on otilimab and RSV maternal
- Continued progress in development of long-acting HIV treatments including launch of Apretude, for HIV prevention and positive data for new broadly neutralising antibody N6LS
- Successful business development to support future growth and focus in Vaccines and Specialty Medicines including Affinivax, Sierra Oncology and Spero Therapeutics</td></tr><tr><td>Demonstrate continued commercial execution excellence</td><td>- Step-change in commercial execution, with double-digit sales growth across Specialty Medicines and Vaccines
- 10 products now exceeding £1 billion in annual sales, including Trelegy, Nucala, Benlysta and Dovato
- Strong momentum for Shingrix (sales +60% to £3 billion), reflecting post pandemic rebound, new geographic launches and excellent commercial execution</td></tr><tr><td>Complete separation and unlocked value</td><td>- Haleon successfully demerged on schedule from GSK on 18 July 2022. Largest demerger in Europe for 20 years
- Meaningful progress in value recognition prior to impact of market uncertainty following Zantac litigation</td></tr><tr><td>Demonstrate strong Environmental, Social and Governance (ESG) credentials and build trust in future delivery</td><td>- Sustained leading ESG performance, with delivery against Global Health, Environment and Inclusion and Diversity commitments
- Maintained sector-leading rankings in key ESG indices. Ranked number 1 in Access to Medicines Index for the 8th consecutive time and 2nd in S&amp;P Corporate Sustainability Assessment for the pharmaceutical industry</td></tr><tr><td>Demonstrate strong culture and leadership</td><td>- Drove rapid ownership of new culture; launch and roll out of new internal GSK Code, Talent Management and Performance with Choice programmes
- Employee engagement up to 81% (versus 78% in 2021)
- Continued development and succession planning for leadership team, with Tony Wood appointed CSO and new Chief Financial Officer Designate appointed</td></tr><tr><td colspan="2">Iain Mackay</td></tr><tr><td colspan="2">The Committee determined that the CFO successfully met his individual objectives</td></tr><tr><td>Demonstrate financial leadership</td><td>- Group financial targets exceeded: total sales £29.3 billion (+19% AER, +13% CER, +10% excl COVID); adjusted operating margin 27.8%; adjusted operating profit growth +26% AER, +14% CER, +17% excl COVID
- Adjusted EPS 1397p (+15% CER)</td></tr><tr><td>Cost discipline and cash flow management</td><td>- Prioritised investment and cost discipline supported strong growth in operating profit and EPS
- Transformation programme delivering £09 billion annual savings by end 2022, on track to deliver £1 billion by end 2023
- Cash generated from operations £79 billion and free cash flow of £3.3 billion</td></tr><tr><td>Complete separation and unlocked value</td><td>- Haleon successfully demerged on schedule from GSK on 18 July 2022. Largest demerger in Europe for 20 years
- Meaningful progress in value recognition prior to impact of market uncertainty following Zantac litigation</td></tr><tr><td>Demonstrate strong culture and leadership</td><td>- Finance and Tech engagement, confidence, culture and inclusivity employee survey scores all increased versus 2021</td></tr></table>

## 2022 ESG: diversity, equity and inclusion (DEI) performance

Our first Annual Bonus ESG measure reinforces achievement of our DEI ambitions, as set out on page 47. DEI is an important business imperative and aspirational targets could be set to warrant additional reward. To stay on track for the 2025 Aspirational Targets for diversity of senior leadership, the Committee agreed interim, annual aspirational targets including global gender representation and US and UK race and ethnicity representation. These interim, annual aspirations were agreed by the Committee for the CEO. An internal governance team comprising members of Reward and Legal audited their performance against these interim aspirations for consideration by the Committee. These interim aspirations were achieved in 2022 and at year end we had 42% gender representation and 31.3% US ethnicity and 14.3% UK ethnicity in our VP and above employee population which are above or on track to meet the 2025 Aspirations.

In addition, most directorates also performed strongly against their respective contributions to our Aspirations. However, not all directorates achieved their expected contributions to the aspirational targets including Finance.



## Annual report on remuneration continued

Pay for performance (audited) continued

## Vesting of PSP LTI awards

The following sets out the performance achieved for the company’s PSP and includes an update on performance of outstanding awards. In line with the Committee’s agreed principles, actual performance against each measure is carefully reviewed and adjustments are made, as appropriate, to ensure that the vesting outcome reflects genuine underlying business performance and has been delivered in line with our culture and responsible business priorities.

Overall, 52% of the 2020 PSP award vested. Targets were set against pipeline progress (20%), innovation sales (20%), adjusted free cash flow (30%) and relative TSR (30%). Disappointingly there was nil-vesting under relative TSR. However, strong performance against other metrics was evidenced with full vesting under the cash flow element and partial vesting under pipeline progress and innovation sales.

During the 2020–22 period, significant progress was achieved in accelerating the delivery of our pipeline, notably the company’s RSV vaccine, depemokimab and niraparib. Robust oversight resulted in a number of assets being discontinued as resources were reprioritised to focus on those with the greatest potential. Major approvals in the period included: niraparib, for ovarian cancer; sotrovimab (emergency use authorization) for COVID-19; Cabenuvab for HIV treatment and Apretude for HIV pre-exposure prevention. Innovation sales, in the period, reflected particularly strong performance of HIV medicines and our shingles vaccine, Shingrix.

<table><tr><td rowspan="2">Performance measures and relative weighting</td><td colspan="8">Outcome and vesting level</td></tr><tr><td colspan="4">Performance targets</td><td>Outcome</td><td>% of maximum</td><td>% of award</td><td></td></tr><tr><td rowspan="4">Pipeline progress (20%)</td><td colspan="4">The pipeline progress measure targets rewarding strengthening of our pipeline through progression of high quality assets into pivotal trials and the achievement of regulatory approvals in major markets. Points based on achievement are allocated to these two equally weighted elements.</td><td>16.5 points</td><td>88%</td><td rowspan="4">13.8%</td><td></td></tr><tr><td>Measure</td><td>LTI award %</td><td>Threshold 25%</td><td>50%</td><td>75%</td><td>19 points</td><td>50%</td></tr><tr><td>Pivotal Trial starts</td><td>10</td><td>13 points</td><td>14 points</td><td>15 points</td><td>18 points</td><td></td></tr><tr><td>Major regulatory approval milestones</td><td>10</td><td>18 points</td><td>19 points</td><td>20 points</td><td>22 points</td><td></td></tr><tr><td rowspan="5">Innovation sales (20%)</td><td colspan="4">The innovation sales measure recognises the importance of launching new products successfully and that driving their performance is key to our commercial success. This measure aggregates three-year sales for new innovative products launched in the three-year performance period and the preceding two years, ie 2018-22.</td><td>£15.368 billion</td><td>41%</td><td>8.2%</td><td></td></tr><tr><td colspan="4">Innovation sales (billion)</td><td>% vesting</td><td></td><td></td><td></td></tr><tr><td>Maximum</td><td>£18.132</td><td></td><td>100%</td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>£16.484</td><td></td><td>75%</td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>£15.660</td><td></td><td>50%</td><td></td><td></td><td></td><td></td></tr><tr><td rowspan="2">Threshold</td><td>£14.836</td><td></td><td>25%</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>&lt;£14.836</td><td></td><td>0%</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td rowspan="5">Adjusted free cash flow (AFCF) performance (30%)</td><td colspan="4">In line with the company’s agreed principles, the AFCF figures included adjustments for a number of material distorting items, including legal settlements, exchange rate movements and special pension contributions.</td><td>£13.08 billion</td><td>100%</td><td>30%</td><td></td></tr><tr><td>Original target (billion)</td><td>Revised target (billion) (1)</td><td>% vesting</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Maximum</td><td>£11.84</td><td>£10.47</td><td>100%</td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>£11.33</td><td>£10.01</td><td>75%</td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>£10.30</td><td>£9.10</td><td>50%</td><td></td><td></td><td></td><td></td></tr><tr><td rowspan="2">Threshold</td><td>£999</td><td>£8.83</td><td>25%</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>&lt;£999</td><td>&lt;£8.83</td><td>0%</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td colspan="9">(1) The revised target has been further adjusted since the 2021 Annual Report as noted overleaf.</td></tr><tr><td rowspan="5">Relative TSR performance (30%)</td><td colspan="4">TSR ranking within comparator group (2)</td><td>Ranked 9th</td><td>0%</td><td>0%</td><td></td></tr><tr><td>Maximum</td><td>1st, 2nd, 3rd</td><td></td><td>100%</td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>4th</td><td></td><td>70%</td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>5th</td><td></td><td>40%</td><td></td><td></td><td></td><td></td></tr><tr><td>Threshold (3)</td><td>Median</td><td></td><td>25%</td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>6th to 10th</td><td></td><td>0%</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td colspan="9">(2) TSR comparator group: AstraZeneca, Bristol-Myers Squibb, Eli Lilly, GSK, Johnson &amp; Johnson, Merck &amp; Co, Novartis, Pfizer, Roche Holdings and Sanofi.</td></tr><tr><td colspan="9">(3) The vesting schedule is based on delivering 25% vesting for median performance. In a comparator group of ten companies, median falls between two companies.</td></tr><tr><td colspan="9">Total vesting in respect of 2020 awards</td></tr></table>



## Annual report on remuneration continued

## Pay for performance (audited) continued

The Adjusted free cash flow (AFCF) target was revised in line with the disclosure on page 131 of the 2021 Annual Report. It has been further restated to take account of the demerger by removing the share of target cash flows related to Consumer Healthcare following the demerger in 2022, revised phasing of the Future Ready programme restructuring cash payments based on detailed programme planning undertaken in 2022, and revised timing of divestments. As a result, the target was decreased by £0.99 billion to £9.10 billion.

The Committee did not exercise any discretion in relation to the vesting of the awards or share price changes.

## 2020 PSP vesting

<table><tr><td></td><td>Granted</td><td>Vested \( ^{(1)} \)</td><td>Value of vested shares \( ^{(1)} \)</td></tr><tr><td>Emma Walmsley \( ^{(2)} \)</td><td>410,090</td><td>248,018</td><td>£3,666,163</td></tr><tr><td>Iain Mackay</td><td>207,267</td><td>125,432</td><td>£1,854,116</td></tr><tr><td>Dr Hal Barron - Pro-rated \( ^{(3)} \)</td><td>203,981</td><td>122,634</td><td>$4,381,400</td></tr></table>

(1) The vested number of shares and the value it represented at vesting includes dividend reinvestments during the performance period. These are based on the vesting price of £14.78 and the closing ADS price of $35.727 on 10 February 2023.

(2) The shares granted for Emma Walmsley include the additional 'top-up' award made in May 2020 which will not vest until May 2023. The final actual value received and any amount attributable to share price appreciation over the performance period will be restated in the 2023 Annual Report.

(3) The PSP award for Dr Hal Barron will not vest until August 2023 under the terms of the Executive & Senior Manager Financial Recoupment Policy.

## Performance of ongoing LTI awards

The Committee also reviewed the performance of the PSP awards granted to Executive Directors in 2021 and 2022.

The following charts provide an estimate of the vesting levels of the 2021 and 2022 awards, taking into account performance to 31 December 2022.

– Actual vesting levels will only be determined based on performance over the full three-year performance periods. The indications below should therefore not be regarded as predictions of the final vesting levels

– The AFCF measure target, threshold and associated vesting scales for the 2021 awards have been adjusted. The net overall impact is a decrease in the target of £3.02 billion to £5.64 billion for the 2021 award

– The adjustments took into account of the following items: the removal of the share of target cash flows relating to Consumer Healthcare in 2022 and 2023 following the demerger in 2022, revised phasing of the Future Ready programme restructuring cash payments, and revised timing of divestments

– There were no changes to other measures

2021 PSP award



2022 PSP award



Commercially sensitive target published on vesting Estimated vesting level Pivotal trial starts Major regulatory approval milestones

For threshold performance 25% of each award will vest in respect of each performance measure. Individual 2021 LTI award levels appear on page 131 of the 2021 Annual Report. They are set out below for the 2022 LTI awards.



## Annual report on remuneration continued

Pay for performance (audited) continued

## 2022 LTI awards

The 2022 DABP awards, in respect of the deferral of 2021 bonus, and the 2022 PSP awards are both shown in the table below.

<table><tr><td rowspan="2"></td><td colspan="3">2022 DABP awards</td><td colspan="3">2022 PSP awards</td></tr><tr><td>2021 % of total bonus deferred</td><td>Number of shares</td><td>Face value of award(1)</td><td>Award level as % of base salary</td><td>Number of shares</td><td>Face value of award(2)(3)</td></tr><tr><td>Emma Walmsley</td><td></td><td>72,399 shares</td><td>£1,138m</td><td>575%</td><td>461,059 shares</td><td>£7.2m</td></tr><tr><td>Iain Mackay</td><td>50%</td><td>50,056 shares</td><td>£0.786m</td><td>400%</td><td>233,028 shares</td><td>£3.7m</td></tr><tr><td>Dr Hal Barron(4)</td><td></td><td>40,617 ADS</td><td>£1.741m</td><td>-</td><td>-</td><td>-</td></tr></table>

(1) The face values of the DABP awards have been calculated based on a share price of £15.712 and an ADS price of $42.87, being the closing prices on 14 February 2022 (the day before grant). These are nil-cost options for the UK Executive Directors and restricted shares for the US Executive Director. No performance conditions are attached to the DABP awards, as they reflect the mandatory three-year deferrals in respect of the Annual Bonus for 2021.

(2) The face values of the PSP awards have been calculated based on a share price of £15.712, being the closing price on 14 February 2022 (the day before grant). These are conditional shares, based on the performance measures outlined above. Dr Barron did not receive a 2022 PSP award given his transition to a Non-Executive Director role on 1 August 2022.

(3) The performance period for the 2022 PSP awards is from 1 January 2022 to 31 December 2024. Awards vest at 25% of maximum for threshold performance.

(4) Dr Barron's DABP award will vest as normal three years after the date it was granted.

## Historical vesting for LTI plans

The following table summarises LTI vesting by performance measure for GSK over the last ten years.

<table><tr><td></td><td>2011</td><td>2012</td><td>2013</td><td>2014</td><td>2015</td><td>2016</td><td>2017</td><td>2018</td><td>2019</td><td>2020</td></tr><tr><td>Relative TSR</td><td>0</td><td>0</td><td>0</td><td>0</td><td>15</td><td>0</td><td>0</td><td>0</td><td>0</td><td>0</td></tr><tr><td>Adjusted free cash flow</td><td>13</td><td>0</td><td>0</td><td>0</td><td>21</td><td>26</td><td>33</td><td>33</td><td>33</td><td>30</td></tr><tr><td>Innovation sales (previously R&amp;D new product)</td><td>16</td><td>7</td><td>21</td><td>33</td><td>33</td><td>33</td><td>33</td><td>33</td><td>25</td><td>8.2</td></tr><tr><td>Pipeline progress</td><td colspan="10"></td></tr><tr><td>Business diversification</td><td>11</td><td>7</td><td>17</td><td colspan="7"></td></tr><tr><td>Total vested %</td><td>40</td><td>14</td><td>38</td><td>33</td><td>69</td><td>59</td><td>67</td><td>67</td><td>58</td><td>52</td></tr></table>

## Malus and clawback policy

For details of our existing policy on malus and clawback, please refer to the company’s 2022 Remuneration policy report on page 147 of the 2021 Annual Report, available on gsk.com.

The Committee reviews and discloses whether it (or the Recoupment Committee) has exercised malus or clawback. Disclosure is only made when the matter has been the subject of public reports of misconduct, where it has been fully resolved, where it is legally permissible to disclose and where it can be made without unduly prejudicing the company and therefore shareholders.

In line with these disclosure guidelines, neither the Committee (nor the Recoupment Committee) exercised malus or clawback during 2022.

An administrative amendment is proposed to the malus and clawback section of the 2022 Remuneration policy for shareholder approval at the 2023 AGM, as described on page 163.

## Other policies

For details of our existing policies on recruitment remuneration, loss of office and termination payments, please refer to the 2022 Remuneration policy report on pages 144 to 152 of the 2021 Annual Report, available on gsk.com.



## Directors' pay in a wider setting

## Internal context

## Remuneration structure for employees compared to Executive Directors and GLT during 2022

<table><tr><td>Element</td><td>Wider workforce pay</td><td>Comparison with Executive Director and GLT pay</td></tr><tr><td>Salary</td><td>- The market competitiveness of base salaries across the company is assessed at a local market level. The competitiveness of roles, which is measured against the external market and internal peers, is kept under regular review
- Increases may also be made to reflect a change in scope of an individual&#x27;s role, responsibilities or experience</td><td>- For our Executive Directors and the GLT, following a performance review, increases in base salaries are considered in line with market practice, the average increase for the wider employee population and other comparator tools.
- Increases may also be made to reflect a change in scope of an individual&#x27;s role, responsibilities or experience
- In agreeing increases for Executive Directors and the GLT, the Committee is mindful of the multiplier effect on the individual&#x27;s total remuneration</td></tr><tr><td>Pensions and benefits</td><td>- The company seeks to provide an appropriate pension and benefits package that is aligned to competitive market practices in those countries in which the company operates and where our employees are based</td><td>- Our Executive Directors and the GLT are eligible to receive benefits broadly in line with the policy for other employees, which may vary by location
- Pension arrangements are structured in accordance with where the Executive Director or GLT member is expected to retire. Current and future Executive Directors&#x27; pension arrangements have been aligned to the wider workforce in their location since 1 January 2023</td></tr><tr><td>Annual Bonus</td><td>- With the exception of our sales force, who participate in separate arrangements, our wider workforce participates in a plan based on performance against four business and financial measures. These are structured to reflect the priorities of each specific business area
- This plan is designed to reward our employees&#x27; collective contribution to business achievement. Separate mechanisms are in place to recognise outstanding individual performance or to address under-performance</td><td>- Our Executive Directors and the GLT participate in a plan based on an assessment of a combination of stretching financial/business, ESG: DEI and personal objectives
- For Executive Directors, any bonus up to 200% of salary is paid 50% in cash and 50% in shares deferred for three years. Any bonus earned in excess of this (up to a maximum of 300% of salary) would be delivered fully in shares deferred for three years
- For GLT members, any bonus up to 170% of salary is paid 75% in cash and 25% in shares deferred for three years. Any bonus earned in excess of this (up to a maximum of 255% of salary) would be delivered fully in shares deferred for three years
- Clawback and/or malus provisions apply</td></tr><tr><td>LTI plans</td><td>- Our employees at Senior Vice President (SVP) and Vice President (VP) level participate in the same PSP as our Executive Directors and the GLT with the same performance targets and periods
- Clawback and/or malus provisions apply
- Our SVP and VP employees, together with Directors and Managers below the GLT, receive annual Share Value Plan awards of restricted shares</td><td>- Our Executive Directors and the GLT are granted annual PSP awards with the same performance targets and periods as employees
- Executive Directors are required to hold vested awards for an additional two-year period
- Clawback and/or malus provisions apply
- Executive Directors and the GLT do not receive Share Value Plan awards following appointment</td></tr></table>

## All-employee share plans

UK Executive Directors may participate in His Majesty’s Revenue & Customs approved all-employee share plans along with the wider UK workforce, namely the company’s Share Save and Share Reward plans.

Participants of the company’s Share Save plan may save up to £250 a month for three years and at the end of the period have the option to buy GSK shares at a discount of up to 20% to the share price at the start of the savings contract. Participants of the Share Reward plan contribute up to £125 a month to purchase GSK shares which the company then matches on a one for one basis.

For further details see page 154.

## Dilution limits

All awards are made under plans which incorporate dilution limits consistent with the guidelines published by the Investment Association (IA). These limits are 10% in any rolling ten-year period for all plans and 5% in any rolling ten-year period for executive share plans (granted to senior executives). Estimated dilution from existing awards made over the last ten years up to 31 December 2022 is as follows:






## Annual report on remuneration continued

Directors' pay in a wider setting continued

## CEO pay ratios – Option A methodology

<table><tr><td>Financial year</td><td>Lower quartile P25</td><td>Median P50</td><td>Upper quartile P75</td></tr><tr><td>2022</td><td>144.1</td><td>106.1</td><td>67.1</td></tr><tr><td>2021</td><td>154.1</td><td>108.1</td><td>67.1</td></tr><tr><td>2020</td><td>130.1</td><td>96.1</td><td>62.1</td></tr><tr><td>2019</td><td>160.1</td><td>119.1</td><td>73.1</td></tr></table>

GSK continues to use the Option A methodology because it is the most robust and statistically accurate way to calculate the three ratios from the options available in the Remuneration regulations. The pay ratio is broadly similar to 2021 with the reduction at P25 influenced by the change in workforce composition following the Consumer Healthcare demerger. The pay ratios above are calculated using actual earnings for the CEO and UK employees. The CEO’s total single figure remuneration of £8,453,253 for 2022 and £8,203,422 for 2021 are detailed on page 136.

Total remuneration for all UK full-time equivalent employees on 31 December 2022 has been calculated in line with the single figure methodology. This reflects their actual earnings received in 2022 (excluding business expenses), which were used to produce the percentile calculation under Option A of the Remuneration regulations. Business expenses have been excluded as they are reimbursed to employees and are not sufficiently substantial in value to significantly impact the ratios.

The table below shows the salary, and total pay and benefits for each of the percentiles.

<table><tr><td></td><td>2022</td><td>2021</td><td>2020</td><td>2019</td><td>2022</td><td>2021</td><td>2020</td><td>2019</td><td>2020</td><td>2019</td></tr><tr><td>£</td><td>P25</td><td></td><td></td><td></td><td>P50</td><td></td><td>P75</td><td></td><td></td><td></td></tr><tr><td>Salary</td><td>37,776</td><td>37,251</td><td>36,924</td><td>34,510</td><td>52,107</td><td>51,492</td><td>50,000</td><td>47,029</td><td>74,905</td><td>72,997</td></tr><tr><td>Total pay and benefits</td><td>58,883</td><td>53,151</td><td>54,133</td><td>50,467</td><td>79,428</td><td>76,234</td><td>73,340</td><td>68,200</td><td>126,594</td><td>122,852</td></tr></table>

The Committee believes that the median pay ratio is consistent with the company’s pay, reward and progression policies. The base salaries of all employees, including the Executive Directors, are set with reference to a range of factors including market practice, experience and performance in role.

## Supplemental and additional ratios

The CEO pay ratio is likely to vary, potentially significantly, over time since it will be driven largely by CEO variable pay outcomes. In line with our reward principles, the CEO has a larger portion of her pay based on performance than the individuals at P25, P50 and P75. This means that depending on GSK’s performance the ratio could increase or decrease significantly.

The Committee believes that our senior executives should have a significant proportion of their pay linked directly to performance.

In light of this we have also provided supplemental ratios, where LTI compensation has been excluded.

We believe this provides an additional view as LTs formed a substantial percentage of the CEO’s total remuneration, which is highly variable and dependent on business performance. The CEO’s 2022 total remuneration excluding LTI compensation is £4,787,090.

CEO pay ratios (less LTI awards)

<table><tr><td rowspan="2">Financial year</td><td colspan="3">Option A Methodology</td></tr><tr><td>P25</td><td>P50</td><td>P75</td></tr><tr><td>2022</td><td>81.1</td><td>60.1</td><td>40.1</td></tr><tr><td>2021</td><td>73.1</td><td>51.1</td><td>34.1</td></tr><tr><td>2020</td><td>51.1</td><td>38.1</td><td>26.1</td></tr><tr><td>2019</td><td>65.1</td><td>48.1</td><td>32.1</td></tr></table>

## Relative importance of spend on pay

The table shows total employee pay and the Group’s dividends paid to shareholders.

<table><tr><td></td><td>Change %</td><td>2022 £m</td><td>2021 £m</td></tr><tr><td>Total employee pay</td><td>0.2</td><td>7,693</td><td>7,680</td></tr><tr><td>Dividends paid in the year</td><td>(13.3)</td><td>3,467</td><td>3,999</td></tr></table>

The figures in the table above, which reflect payments made during each year and the impact of movements in exchange rates, are as set out on pages 200 and 207. However, cash dividends declared in respect of 2022 were £2,468 million (2021: £4,011 million) a decrease of 38.5%. Please see Note 16 to the financial statements for further details.

Total employee pay is based on 69,130 employees, the average number of people employed during 2022 (2021: 71,345). Please see Note 9 to the financial statements for further details.

There were no share repurchases made by the company during 2022 and 2021.



## Annual report on remuneration continued

Directors' pay in a wider setting continued

## External context

## Comparator groups

The Committee used two pay comparator groups when considering executive pay for 2022. The European cross-industry comparator group is the primary comparator group used for the CEO and CFO. The Global pharmaceutical comparator group is the secondary group for the CEO and is also used to measure relative TSR performance.

European cross-industry comparator group

<table><tr><td>Roche Holding AG</td><td>Linde</td><td>Deutsche Telekom</td></tr><tr><td>Novartis</td><td>Sanofi</td><td>Kering</td></tr><tr><td>LVMH</td><td>AstraZeneca</td><td>Heineken</td></tr><tr><td>Anheuser-Busch InBev</td><td>Diageo</td><td>BASF</td></tr><tr><td>Unilever</td><td>Siemens</td><td>Vinci</td></tr><tr><td>SAP</td><td>Christian Dior</td><td>Adidas</td></tr><tr><td>L&#x27;Oreal</td><td>Inditex</td><td>Bayer</td></tr><tr><td>Novo Nordisk A/S</td><td>BAT</td><td>Safran</td></tr><tr><td>Airbus</td><td>Volkswagen</td><td>Reckitt Benckiser</td></tr></table>

Global pharmaceutical comparator group

<table><tr><td>France</td><td>US</td></tr><tr><td>Sanofi</td><td>AbbVie \( ^{(1)} \)</td></tr><tr><td>Switzerland</td><td>Amgen \( ^{(1)} \)</td></tr><tr><td>Novartis</td><td>Bristol-Myers Squibb</td></tr><tr><td>Roche Holdings</td><td>Eli Lilly</td></tr><tr><td>UK</td><td>Johnson &amp; Johnson</td></tr><tr><td>AstraZeneca</td><td>Merck &amp; Co</td></tr><tr><td></td><td>Pfizer</td></tr></table>

(1) AbbVie and Amgen are included for remuneration benchmarking, but are not included in the relative TSR comparator group.

## 2022 target CEO total remuneration positioning

When reviewing the CEO’s remuneration, the Committee’s primary comparator group is the European cross-industry comparator group. It also references pay for the Global pharmaceutical comparator group.



Remuneration includes salary and the expected value of incentives based on the Committee’s agreed benchmarking methodology.

## TSR Performance graph

The following graph sets out the performance of the company relative to the FTSE 100 Index and to the Global pharmaceutical performance comparator group for the ten-year period to 31 December 2022. These indices were selected for comparison purposes as they reflect both the primary index of which GSK is a constituent and the industry in which it operates.



* This index comprises AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Johnson & Johnson, Merck & Co, Novartis, Pfizer, Roche Holdings and Sanofi.

Historic CEO remuneration

<table><tr><td>Emma Walmsley</td><td></td><td></td><td></td><td></td><td></td><td>£000</td></tr><tr><td></td><td>2022</td><td>2021</td><td>2020</td><td>2019</td><td>2018</td><td>2017</td></tr><tr><td>Total remuneration</td><td>8,453</td><td>8,203</td><td>7,031</td><td>8,094</td><td>5,887</td><td>4,883 \( ^{(1)} \)</td></tr><tr><td>% of maximum</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Annual Bonus award \( ^{(2)} \)</td><td>83%</td><td>93%</td><td>49%</td><td>79%</td><td>93%</td><td>77%</td></tr><tr><td>Vesting of LTI awards</td><td>52%</td><td>58%</td><td>67%</td><td>67%</td><td>59%</td><td>69%</td></tr><tr><td>Sir Andrew Witty</td><td></td><td></td><td></td><td></td><td></td><td>£000</td></tr><tr><td></td><td>2017</td><td>2016</td><td>2015</td><td>2014</td><td>2013</td><td></td></tr><tr><td>Total remuneration</td><td>715 \( ^{(2)} \)</td><td>6,830</td><td>6,661</td><td>3,902</td><td>7,207</td><td></td></tr><tr><td>% of maximum</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Annual Bonus award \( ^{(2)} \)</td><td>0% \( ^{(2)} \)</td><td>97%</td><td>100%</td><td>42%</td><td>88%</td><td></td></tr><tr><td>Vesting of LTI awards</td><td>0% \( ^{(3)} \)</td><td>33%</td><td>38%</td><td>14%</td><td>31%</td><td></td></tr></table>

(1) Emma Walmsley's total remuneration includes her pay for the period 1 January to 31 March 2017, before she became CEO.

(2) Sir Andrew Witty received a pro-rata payment for 2017 in lieu of a variable bonus opportunity, in accordance with the 2014 Remuneration policy.

(3) PSP and DABP awards for Sir Andrew Witty granted in 2015 did not vest until April 2018, in accordance with the terms of the Executive financial recoupment policy.



## Implementation of Remuneration policy for 2023

## Fixed Pay

## Salary

The Committee is very aware of the sensitivity amongst stakeholders to levels of Executive pay. Before reviewing Executive Directors' salary, it considered the average increases being awarded to employees below the level of Executive Directors and was mindful of the multiplier effect of increases in base pay. After due consideration of the wider economic context, individual performance and market positioning it was agreed that it was appropriate to award increases below that of the wider workforce to the CEO.

During the year, in addition to the 5% average salary increase, the company has implemented a number of monetary initiatives for our colleagues in the wider workforce, in reaction to the cost of living crisis, which can be found on pages 134 and 135.

<table><tr><td>Base salary</td><td>2023</td><td>% change</td></tr><tr><td>Wider workforce \( ^{(1)} \)</td><td>—</td><td>5%</td></tr><tr><td>Emma Walmsley</td><td>£1,310,249</td><td>4%</td></tr><tr><td>Iain Mackay \( ^{(2)} \)</td><td>£915,335</td><td>0%</td></tr></table>

(1) Based on the average increase budget for employees below the level of GLT in the UK.

(2) As a known leaver on 31 December 2023, Mr Mackay is not eligible to receive a salary increase.

## Benefits

No significant changes to the provision of benefits are proposed for 2023.

For full details of the policy in relation to benefits, please refer to the 2022 Remuneration policy report on page 144 of the 2021 Annual Report.

## Pension

The table below provides an overview of the pension arrangements for each Executive Director in 2023.

Executive Directors' pensions were reduced to align with the wider UK workforce effective 1 January 2023.

Any new Executive Director’s pension will be aligned to the appropriate wider workforce on appointment.

2023 Pension contribution

<table><tr><td>Emma Walmsley</td><td>- 7% of base salary contribution to defined contribution plan and a further 3% in matched contributions on the first £26,666 of salary in accordance with the terms of the plan and</td></tr><tr><td></td><td>- 7% of base salary as a cash payment in lieu of pension contribution on salary in excess of £26,666, or</td></tr><tr><td></td><td>- 7% of base salary as a cash payment in lieu of pension contribution</td></tr></table>

## Pay for performance

## Annual Bonus

There are no changes to the operation of the Annual Bonus plan. For full details of the policy please refer to pages 145 and 146 of the 2021 Annual Report.

<table><tr><td rowspan="2"></td><td colspan="3">Bonus opportunity % of salary</td></tr><tr><td>Target</td><td>Maximum \( ^{(1)} \)</td><td></td></tr><tr><td>Emma Walmsley</td><td>100</td><td>300</td><td></td></tr><tr><td>Iain Mackay</td><td></td><td></td><td></td></tr></table>

(1) 50% of the equivalent of the first 200% of salary is deferred, and any portion in excess of 200% is deferred in full.

<table><tr><td rowspan="2"></td><td colspan="4">Weighting of performance measures %</td></tr><tr><td>Total sales growth</td><td>Adjusted operating profit growth</td><td>Strategic and operational measures</td><td>ESG: diversity, equity and inclusion</td></tr><tr><td>Emma Walmsley</td><td>30</td><td>30</td><td>30</td><td>10</td></tr><tr><td>Iain Mackay</td><td></td><td></td><td></td><td></td></tr></table>

Inevitably, targets linked directly to our financial and strategic plan are commercially sensitive. The Committee does not consider it appropriate to disclose Annual Bonus targets during the year, as it may result in competitive harm. However, details of the performance targets will, as usual, be disclosed on a retrospective basis in the 2023 Annual Report.

## Deferred Annual Bonus Plan (DABP) 2023 awards

The table below provides details of the mandatory deferral into the DABP of the 2022 Annual Bonus payments and the associated awards granted. The shares awarded have no performance conditions, but must be held for three years, regardless of continued employment.

<table><tr><td></td><td>Total bonus deferred into shares %</td><td>DABP awards</td></tr><tr><td>Emma Walmsley</td><td>59.9</td><td>Shares</td></tr><tr><td>Iain Mackay</td><td>56.0</td><td>77,751</td></tr></table>

## Performance Share Plan (PSP) 2023 awards

The table below provides details of awards granted under the PSP.

<table><tr><td></td><td>% of salary</td><td>Shares</td></tr><tr><td>Emma Walmsley</td><td>575</td><td>501,927</td></tr></table>

## LTI performance measures

The measures and weightings for the 2023 awards remain unchanged from those used for the 2022 awards. The weightings for the five LTI measures are:

<table><tr><td>LTI measure</td><td>Measure</td><td>Weighting</td></tr><tr><td>Innovation</td><td>Pipeline progress</td><td>20%</td></tr><tr><td>Performance</td><td>Relative TSR</td><td>30%</td></tr><tr><td></td><td>Total sales growth</td><td>20%</td></tr><tr><td></td><td>Adjusted operating profit growth</td><td>20%</td></tr><tr><td>Trust</td><td>ESG: environment</td><td>10%</td></tr></table>



## Annual report on remuneration continued

## Implementation of Remuneration policy for 2023 continued

## Innovation

The Pipeline progress measure seeks to reward acceleration and strengthening of the pipeline. This is based on two equally weighted elements of our key assets or indications measured over a three-year performance period.

Points are allocated for successful assets in each sub-measure based upon their forecast commercial value (peak year sales) at the end of the performance period.

The sub-measures for the 2023 award will vest as follows:

## Pivotal trial starts

Focuses mainly on phase III registrational trial starts, but may also include phase II starts.

<table><tr><td>Performance level</td><td>Points</td><td>Payout</td></tr><tr><td>Below Threshold</td><td>&lt;12</td><td>Nil</td></tr><tr><td>Threshold</td><td>12</td><td>25%</td></tr><tr><td></td><td>14</td><td>50%</td></tr><tr><td></td><td>16</td><td>75%</td></tr><tr><td>Maximum</td><td>20</td><td>100%</td></tr></table>

## Major regulatory approvals

<table><tr><td>Performance level</td><td>Points</td><td>Payout</td></tr><tr><td>Below Threshold</td><td>&lt;17</td><td>Nil</td></tr><tr><td>Threshold</td><td>17</td><td>25%</td></tr><tr><td></td><td>19</td><td>50%</td></tr><tr><td></td><td>20</td><td>75%</td></tr><tr><td>Maximum</td><td>22</td><td>100%</td></tr></table>

The Pipeline progress measure is commercially sensitive at the time of grant. At the end of the performance period we will provide disclosure of what has been achieved.

## Shareholdings versus Share Ownership Requirement (SOR) (audited)

To align the interests of Executive Directors with those of shareholders, they are required to build and maintain significant holdings of shares in GSK over time. Executive Directors are required to continue to satisfy these Share Ownership Requirements (SOR) by holding 100% of their SOR for the first 12 months after leaving GSK and not less than 50% of their SOR for months 13-24 after leaving GSK.

<table><tr><td rowspan="2"></td><td colspan="3">Value of holdings as % of salary</td></tr><tr><td>SOR % of salary</td><td>3 March 2023</td><td>31 December 2022</td></tr><tr><td>Emma Walmsley</td><td>650</td><td>1,292</td><td>1,031</td></tr><tr><td>Iain Mackay</td><td>300</td><td>406</td><td>228</td></tr></table>

## Performance

Relative TSR will continue to be measured against GSK’s Global pharmaceutical comparator group (see page 146). The total sales growth and adjusted operating profit growth measures recognise the importance of our commercial ambitions and the Committee has set targets that align with those ambitions. The targets for total sales growth and adjusted operating profit growth are commercially sensitive at the time of grant.

## ESG: environment

The ESG: environment measure is based on the goal of having a Nature Net Positive and Climate Net Zero impact by 2030 (see pages 45 and 46). The targets for the ESG: environment measure for the 2023 grant are based on a series of Nature goals relating to Water, Waste & Materials reduction, Biodiversity impact and Climate goals that incorporate Scope 1 & 2 emission reduction targets, carbon offsetting and our industrialisation of green Ventolin.

The ESG: environment measure includes six key performance measures:

– 3x Climate ambitions

– 3x Nature ambitions

To achieve:

– 75% vesting, all six measures must have met their 2025 targets

– 100% vesting, two of the six measures, at least one in Climate and one in Nature, must have exceeded their 2025 targets

Shares subject to performance conditions are excluded from each Executive Director’s SOR calculation until the end of the performance period. These vested shares are then included as part of the Director’s SOR to the extent that the performance conditions are met. The value of the holdings has been calculated on a post-tax basis.

Emma Walmsley and Iain Mackay, at the date of publication of this Report, exceed their SOR. Dr Hal Barron exceeded his SOR prior to his transition to a Non-Executive Director role on 1 August 2022.

The company has processes in place to ensure that each Executive Director maintains their SOR after leaving GSK. Each Executive Director agrees to the terms of the SOR as part of their service contract.



## Annual report on remuneration continued

Implementation of Remuneration policy for 2023 continued

## Termination arrangements for Executive Directors

As announced during 2022, Iain Mackay will step down as CFO and Executive Director on 1 May 2023, continue as an employee and leave the company on 31 December 2023.

<table><tr><td>Remuneration element</td><td>Summary of treatment</td></tr><tr><td>Annual Bonus</td><td>Eligible to receive bonuses which will be determined by the Committee based on a combination of business and individual performance for his service during 2022 and 2023.</td></tr><tr><td>PSP</td><td>Not eligible to receive any further PSP awards.</td></tr><tr><td>Outstanding PSP and DABP awards</td><td>All existing LTI awards will be retained and PSP awards will be pro-rated for time.</td></tr><tr><td>DABP deferred bonus awards</td><td>Awards in respect of bonuses deferred in 2022 and prior years will vest at their normal vesting dates.</td></tr></table>

In addition to the above, Iain Mackay will be required to maintain his SOR in accordance with the company’s Remuneration policy.

## Remuneration arrangements for Julie Brown

The Committee considered the remuneration arrangements that would be appropriate to enable the company to recruit and retain an experienced CFO within the criteria for the role in the company’s 2022 Remuneration policy.

Given Julie Brown’s wealth of experience as a CFO and of the industry, it was agreed that her remuneration should be set in line with Iain Mackay’s remuneration, as follows:

<table><tr><td>Remuneration element</td><td>Notes</td></tr><tr><td>Salary</td><td>£951,948</td></tr><tr><td>Annual Bonus</td><td>£951,948</td></tr><tr><td>Award of Long Term Incentives (LTIs)</td><td>£1,903,896</td></tr><tr><td>Share Ownership Requirement (SOR)</td><td>300% of salary</td></tr><tr><td>Pension</td><td></td></tr><tr><td>Benefits</td><td></td></tr></table>

The Committee sought to ensure Ms Brown was compensated on a like-for-like basis as far as possible when concluding her buyout payments, which are set out below:

– a sum (the Bonus Buyout) equivalent to Ms Brown’s on-target Burberry bonus for the period from 1 April 2022 to 31 March 2023, which she will forego on leaving Burberry

– a sum (the LTI Buyout) equivalent to the aggregate value of (i) her outstanding Burberry LTIs and SIP shares, which will be lost on leaving Burberry, at a price equivalent to the average price of such shares for the one-month period ended on 7 September 2022, and (ii) the value of any dividend equivalents accruing on those shares between their date of award and her departure from Burberry. Given that the Burberry LTIs are not subject to a performance measure, and only to a performance underpin, no discount will be applied to the value of the shares so calculated

The Committee agreed that these payments would be made in stages over a two year period as follows, as cash amounts equivalent to:

– the Bonus Buyout and one-third of 85% of the LTI Buyout will be paid to her in the first payroll following the commencement of her employment with GSK

– one-third of 85% of the LTI Buyout will be paid to her in the first payroll following the first anniversary of the commencement of her employment and

– one-third of 85% of the LTI Buyout will be paid to her in the first payroll following the second anniversary of the commencement of her employment

In addition, she will be paid an amount equivalent to 15% of the LTI Buyout in the first payroll following the commencement of her employment. Ms Brown has agreed that she will invest the net of tax proceeds of this 15% tranche in GSK shares at the first reasonably available opportunity, subject to dealing clearance, and that she will then hold those shares for a period of at least two years. Ms Brown’s SOR as CFO will be three times her base salary which she will be required to build over time.



## Remuneration governance

## Committee role and membership

These details are available on page 107 and are incorporated by reference into this Report. The Chair, CEO, Chief People Officer, Head of Reward, Group Financial Controller and the Company Secretary assisted the Committee during the year.

## Adviser to the Committee

The company undertook a full commercial tender process during 2022 and appointed Willis Towers Watson LLP (WTW) as independent adviser to the Committee with effect from 1 December 2022. WTW replaced PricewaterhouseCoopers LLP (PwC) who served as independent adviser up to 1 December 2022 and for over four years in total.

Both WTW and PwC are members of the Remuneration Consultants' Group and, as such, voluntarily operate under the code of conduct in relation to executive remuneration consulting in the UK. The code of conduct can be found at www.remunerationconsultantsgroup.com.

WTW provided additional market data to the Committee and other HR consulting services to the company prior to and after their appointment as independent Committee advisers. During the year, in addition to providing consultancy services to the Committee, PwC also provided other consulting and assurance services to the company prior to WTW’s appointment.

In line with the protocols agreed and set by the Committee Chair under which WTW and PwC provided their advice, the Committee is satisfied that such advice has been objective and independent. During their respective tenures in 2022, PwC and WTW have provided independent commentary on matters under consideration by the Committee and updates on market practice and legislative requirements.

The Committee also reviewed the potential for conflicts of interest and judged that there were appropriate safeguards against such conflicts. WTW’s and PwC’s fees for advice during that period, which were charged on a time and materials basis, were £4,000 and £162,945 respectively. The Committee is satisfied that these fees did not compromise either firm’s independence.
Statement of consideration of shareholder views
The Committee engages in regular dialogue with shareholders and holds annual meetings with GSK’s largest investors to discuss and take feedback on its Remuneration policy practices and governance matters.

## 2022 AGM voting

Details of voting levels in respect of our Remuneration arrangements are set out below.

<table><tr><td></td><td>Total votes cast (billion)</td><td>Total votes for (%)</td><td>Total votes against (%)</td><td>Votes withheld (million)</td></tr><tr><td>2022 AGM</td><td></td><td></td><td></td><td></td></tr><tr><td>Remuneration report</td><td>3.6</td><td>91.05</td><td>8.95</td><td>12.3</td></tr><tr><td>Remuneration policy</td><td>3.6</td><td>61.76</td><td>38.24</td><td>13.3</td></tr></table>

## Service contracts and letters of appointment

The table below sets out the dates of the Executive Directors' service contracts, which are available for review at the company's registered office and on gsk.com, with the exception of Julie Brown, whose contract will be available on gsk.com following her appointment. Each Executive Director's service contract contains a 12-month notice period.

<table><tr><td></td><td>Date of contract</td><td>Effective date</td><td>Expiry date</td></tr><tr><td>Emma Walmsley</td><td>29.0317</td><td>01.0417</td><td>30.06.34</td></tr><tr><td>Iain Mackay</td><td>18.0918</td><td>14.0119</td><td>n/a</td></tr><tr><td>Julie Brown</td><td>25.0922</td><td>01.05.23</td><td>n/a</td></tr></table>

The Non-Executive Directors have letters of appointment, which are available to view at the company’s registered office. Each Non-Executive Director is expected to serve on the Board until the end of the AGM following the third anniversary of their appointment. This is subject to election and subsequent annual re-election. Subject to mutual agreement, they are each expected to serve a further three years, and up to nine years from appointment in line with the provisions of the FRC’s UK Corporate Governance Code, subject to annual re-election.



## Annual report on remuneration continued

## Remuneration governance continued

## Committee focus during 2022

## Remuneration policy

The Committee sets the Remuneration policy for shareholder approval and then determines the remuneration of the Executive Directors, the Chair and other corporate officers in line with that policy.

## Salary review

The Committee periodically reviews and considers the remuneration environment for Executive Directors and GLT and approves, when appropriate, annual adjustments as necessary having regard to performance, market positioning and the remuneration of the wider workforce.

## Annual Bonus

The Committee is responsible for setting specific performance measures for the Annual Bonus and for assessments of performance against these measures.

## LTI plans

The Committee is responsible for approving LTI plan rule changes, grants, assessments of performance, and the vesting of LTI awards for the Executive Directors, GLT and below (including interim awards).

## Governance and other areas of focus

The Committee adheres to a robust remuneration governance framework, ensuring alignment between internal actions and external reporting/compliance requirements.

## Items discussed

– Prepared and agreed the proposed 2022 Remuneration policy

– Remuneration impact of Consumer Healthcare demerger

– Shareholder and advisory body engagement on new Remuneration policy. See page 133 for further details

– Review and consideration of shareholder and proxy adviser feedback

– Amendments to the proposed Remuneration policy following careful consideration of shareholder feedback

– Continued engagement with shareholders

– Executive Director and GLT benchmarking, competitiveness and GSK comparator groups

– GLT and Company Secretary salary review and recommendations for 2022

– Executive Director salary review and recommendations for 2023

– Setting remuneration for Julie Brown, the new CFO

– Review of company Chair’s fee

– CEO, Executive Directors and GLT 2021 bonus recommendations and 2022 CEO and Executive Directors' bonus objectives

– Proposed new Annual Bonus performance measures aligned with June 2021 Investor Update commitments

– LTI performance outcomes and award vesting for the CEO, Executive Directors, GLT and below

– Confirmation of LTI grants for the CEO, Executive Directors, GLT and below

– Proposed new performance conditions aligned with June 2021 Investor Update commitments

– Remuneration considerations and Committee programme for 2022

– Review of Terms of Reference

– Committee evaluation annual review

– 2021 Remuneration report

– Confirmation of 2022 Group Budget for remuneration purposes
– AGM and Remuneration report feedback, the external remuneration environment and performance target disclosure for incentive plans

– 2022 Remuneration report disclosures, including CEO pay ratio

– Annual Governance Meeting key Committee messages

– Committee Chair consultation with employee representatives on setting pay and wider workforce pay practices

– Remuneration adviser tender process



## Non-Executive Directors' fees

## Chair and other Non-Executive Directors

The company aims to provide the Chair and other Non- Executive Directors with fees that are competitive with those paid by other companies of equivalent size and complexity, subject to the limits contained in its Articles of Association.

## Chair's fees

The Chair’s fee was set at £700,000 per annum, nearly four years ago in September 2019 when he was first appointed to the Board. It has remained unchanged since that time. After a review of independently sourced data by the Committee in January 2023 it was agreed that it was appropriate to increase his fees by £35,000 to £735,000 from 1 January 2023 – a 5% increase from the rate originally set in 2019.

During 2022 the Chair invested approximately 25% of his pre-tax fees in notional shares under the GSK NED share allocation plan (NED plan). Since September 2022 he invests approximately 25% of his net fees in the purchase of GSK shares.

## 2022 Non-Executive Directors' fees

The Non-Executive Directors' fees that applied during 2022 are set out in the table below:

<table><tr><td></td><td>Per annum</td></tr><tr><td>Standard annual fee</td><td>£95,000</td></tr><tr><td>Supplemental fees</td><td></td></tr><tr><td>Chair of the Audit &amp; Risk Committee</td><td>£80,000</td></tr><tr><td>Senior Independent Director</td><td>£50,000</td></tr><tr><td>Scientific &amp; Medical Experts</td><td>£30,000</td></tr><tr><td>Chairs of the Remuneration, Corporate Responsibility and Science committees and Workforce Engagement Director</td><td>£40,000</td></tr><tr><td>Science Committee members undertaking significant additional responsibilities on behalf of GSK to support R&amp;D</td><td>Up to £200,000</td></tr><tr><td>Non-Executive Director undertaking intercontinental travel to meetings</td><td>£7,500 per meeting</td></tr></table>

## Standard annual fee for Non-Executive Directors

The standard Non-Executive Director annual fee was last increased in 2020. Following a review of independently sourced data and recognising the ever-increasing workload for Non-Executive Directors it was agreed that it was appropriate to increase the standard annual fee by £3,800 (4%) from £95,000 to £98,800 per annum from 1 January 2023.

With a view to further simplicity, creating greater transparency of the overall standard Non-Executive Director fee and based on review of independent data, going forward the intercontinental travel allowance of £7,500 per meeting will be added to the standard fee. Ordinarily, Non-Executive Directors are expected to travel overseas to attend two meetings per year and so can expect to receive two travel allowance payments totalling £15,000. The Chair does not receive this allowance. This amount will now be added to the Non-Executive Director standard fee from 1 January 2023 bringing the total standard fee to £113,800.

## Non-Executive Director Share Ownership Requirement

Following approval of the new Remuneration policy at the last AGM, in July 2022 it was agreed to implement a minimum Non-Executive Director share ownership requirement (SOR) of at least one times the annual standard fee (or the Chair’s fee) to be maintained until after retirement from the Board. The Chair, non-US based Non-Executive Directors and newly appointed Non-Executive Directors commenced purchasing shares or ADS in the market towards their new Non-Executive Director SOR from September 2022. US Non-Executive Directors began purchasing ADS towards their SOR from 1 January 2023.

Shareholder approval will be sought at the AGM for an administrative amendment to the Non-Executive Director section of the Remuneration policy to allow the notional shares or ADS previously allocated under the Non-Executive Director plan to be delivered to the Chair and Non-Executive Directors at such time as the Committee and Board considers appropriate after any applicable tax withholding. This would be subject to the Chair and Non-Executive Directors undertaking to hold these shares or ADS until they retire from the Board. This change will not only give the company greater operational flexibility, it will also reduce the administrative burden of operating the Non-Executive Director plan, and will ensure that the Chair and Non-Executive Directors directly maintain a meaningful and prudent level of investment which closer aligns their interests with shareholders.

The company does not expect to make any significant changes to the fee structure for Non-Executive Directors during the remainder of the 2022 Remuneration policy period.



## Annual report on remuneration continued

## 2022 Total fees (audited)

The audited table below sets out the value of fees and benefits received by the Non-Executive Directors in the form of cash and shares or ADS. Further details of the NED plan are set out on page 155. Non-Executive Directors fees paid in a currency other than Sterling are converted using an average exchange rate that is reviewed from time to time. The average exchange rates were updated in 2022. Non-Executive Directors fees were converted to US Dollars using an exchange rate of $1.3481 in 2022. Benefits comprise the grossed up cash value of travel and subsistence costs incurred in the normal course of business, in relation to attendance at Board and Committee meetings and in fulfilling their role as Non-Executive Directors.

<table><tr><td rowspan="2">Non-Executive Directors&#x27; emoluments (000) (audited)</td><td colspan="4">Fixed fees</td><td colspan="4">Fixed fees</td><td rowspan="2">2021</td></tr><tr><td>Cash</td><td>Shares/ADS</td><td>Benefits</td><td>Total pay</td><td>Cash</td><td>Shares/ADS</td><td>Benefits</td><td>Total pay</td></tr><tr><td>Sir Jonathan Symonds</td><td>£525</td><td>£175</td><td>£10</td><td>£710</td><td>£525</td><td>£175</td><td>£3</td><td>£703</td><td></td></tr><tr><td>Elizabeth McKee Anderson</td><td>$35</td><td>$8</td><td>-</td><td>$43</td><td>-</td><td>-</td><td>-</td><td>-</td><td></td></tr><tr><td>Charles Bancroft</td><td>-</td><td>$287</td><td>$10</td><td>$297</td><td>-</td><td>$210</td><td>$5</td><td>$215</td><td></td></tr><tr><td>Dr Hal Barron</td><td>$150</td><td>$16</td><td>$11</td><td>$177</td><td>-</td><td>-</td><td>-</td><td>-</td><td></td></tr><tr><td>Dr Anne Beal</td><td>$138</td><td>$46</td><td>$15</td><td>$199</td><td>$62</td><td>$21</td><td>-</td><td>$83</td><td></td></tr><tr><td>Dr Hal Dietz</td><td>$174</td><td>$58</td><td>$2</td><td>$234</td><td>-</td><td>-</td><td>-</td><td>-</td><td></td></tr><tr><td>Dr Jesse Goodman</td><td>$182</td><td>$61</td><td>$31</td><td>$274</td><td>$164</td><td>$55</td><td>$23</td><td>$242</td><td></td></tr><tr><td>Urs Rohner</td><td>£112</td><td>£31</td><td>£23</td><td>£166</td><td>£101</td><td>£34</td><td>£11</td><td>£146</td><td></td></tr><tr><td>Dr Vishal Sikka</td><td>-</td><td>$58</td><td>-</td><td>$58</td><td>-</td><td>-</td><td>-</td><td>-</td><td></td></tr><tr><td>Retired Directors</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Vindi Banga(1)</td><td>£65</td><td>£22</td><td>£4</td><td>£91</td><td>£109</td><td>£36</td><td>£1</td><td>£146</td><td></td></tr><tr><td>Dame Vivienne Cox(1)</td><td>£55</td><td>£18</td><td>£1</td><td>£74</td><td>£101</td><td>£34</td><td>£1</td><td>£136</td><td></td></tr><tr><td>Lynn Elsenhans(1)</td><td>$74</td><td>$25</td><td>$23</td><td>$122</td><td>$134</td><td>$45</td><td>$5</td><td>$184</td><td></td></tr><tr><td>Dr Laurie Glimcher(2)</td><td>-</td><td>$136</td><td>$20</td><td>$156</td><td>-</td><td>$165</td><td>$13</td><td>$178</td><td></td></tr></table>

(1) Retired from the Board on 18 July 2022.

(2) Retired from the Board on 13 October 2022.



## Directors' interests in shares (audited)

## Executive Directors' interests in shares

The interests of the Executive Directors of the company in office during 2022 and their persons closely associated (PCA) are shown in the table below:

<table><tr><td rowspan="3"></td><td colspan="6">As at 31 December 2022</td></tr><tr><td colspan="3">Total directors&#x27; interests</td><td colspan="3">Unvested share plan interests</td></tr><tr><td>3 March 2023 \( ^{(1)} \)</td><td>31 December 2022 \( ^{(1)} \)</td><td>Beneficial interests</td><td colspan="2">Not subject to performance</td><td>Subject to performance</td></tr><tr><td>Shares</td><td></td><td></td><td>Shares/ADS \( ^{(2)} \)</td><td>Shares/ADS \( ^{(3)(7)} \)</td><td>Options \( ^{(4)(7)} \)</td><td>Shares/ADS \( ^{(5)} \)</td></tr><tr><td>Emma Walmsley</td><td>1,503,484</td><td>1,334,155</td><td>493,081</td><td>656,084</td><td>184,990</td><td>1,550,844</td></tr><tr><td>Iain Mackay</td><td>471,595</td><td>284,967</td><td>-</td><td>157,965</td><td>127,002</td><td>783,978</td></tr><tr><td>ADS</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Dr Hal Barron</td><td>552,499</td><td>547,374</td><td>306,004</td><td>241,370</td><td>-</td><td>348,459</td></tr></table>

1) Total directors' interests includes beneficial interests and unvested share plan interests not subject to performance. For Emma Walmsley and Iain Mackay, the balance as at 3 March 2023 includes shares/ADS awarded in 2020 under the PSP and the DABP which vested in February 2023 less those sold to satisfy tax liabilities on the vested amounts where relevant. ADS awarded in 2020 under the PSP and the DABP to Dr Hal Barron will not vest until August 2023 in accordance with the terms of the Executive and Senior Management Recoupment Policy. Executive Directors' shareholdings against their SOR are outlined on page 148.

2) Beneficial interests includes shares/ADS held by the Executive Directors and their PCAs. For Emma Walmsley, this includes 2,166 shares purchased through the GSK Share Reward plan. Iain Mackay does not currently participate in the Share Reward plan. As a US employee, Dr Hal Barron was not eligible to participate in the Share Reward plan which is only open to UK employees. Dr Barron's beneficial interests include ADS and notional ADS held by way of his investments in the GSK 401(k) plan and the Executive Supplemental Savings Plan (ESSP). Further details on Dr Barron's membership of these plans can be found on page 138.

3) Unvested shares/ADS not subject to performance represent PSP shares/ADS which have vested but are subject to an additional two-year holding period. Unvested ADS not subject to performance for Dr Barron also represent bonus deferrals (as described in note 7 below).

4) Unvested options not subject to performance represent bonus deferrals under the DABP which are awarded as nil-cost options (as described in note 7 below). This figure excludes 790 options held by Emma Walmsley under the GSK Share Save plan.

5) Unvested shares/ADS subject to performance represent unvested PSP awards.

6) Vested but unexercised options: None of the Directors hold vested but unexercised options.

7) DABP: The table below shows bonus deferrals and subsequent reinvestment of dividends under the DABP. The amounts represent the gross shares/ADS balances prior to the sale of any shares/ADS to satisfy tax liabilities on vesting. As UK employees, bonus deferrals under the DABP are granted as nil-cost options to Emma Walmsley and Iain Mackay.

<table><tr><td>DABP (Bonus deferrals)</td><td>3 March 2023</td><td>31 December 2022</td><td>1 January 2022</td></tr><tr><td>Shares</td><td></td><td></td><td></td></tr><tr><td>Emma Walmsley</td><td>251,541</td><td>184,990</td><td>176,801</td></tr><tr><td>Iain Mackay</td><td>164,988</td><td>127,002</td><td>71,972</td></tr><tr><td>ADS</td><td></td><td></td><td></td></tr><tr><td>Dr Hal Barron</td><td>104,563</td><td>103,600</td><td>101,801</td></tr></table>

8) Options exercised in 2022: The following table sets out details of options (including nil-cost options under the DABP) exercised during 2022 by Executive Directors. Iain Mackay did not exercise any options during the year.

<table><tr><td>Type of award</td><td>Date of grant</td><td>Number of shares under option</td><td>Date of exercise</td><td>Grant price</td><td>Market price at exercise</td><td>Gain on exercise</td></tr><tr><td>Emma Walmsley</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Deferral award - DABP</td><td>13.02.2019</td><td>72,296</td><td>14.02.22</td><td>£0.00</td><td>£16.10</td><td>£1,164,000</td></tr><tr><td>Share Save</td><td>29.11.2018</td><td>744</td><td>25.02.22</td><td>£12.09</td><td>£15.82</td><td>£2,775</td></tr></table>

In respect of the nil-cost options awarded in 2019 under the DABP, the bonus which is deferred by the Executive Director was recorded as remuneration (under Annual Bonus) in the Total remuneration table in respect of 2018. The number of shares under option includes the initial award amount together with reinvested dividends accrued to the date of exercise.

In respect of options under the GSK Share Save plan, the remuneration receivable by an Executive Director is calculated on the date that the options first vest. The remuneration is the difference between the amount the Executive Director is required to pay to buy the shares and the total value of the shares on the vesting date. If the Executive Director chooses not to exercise the options on the vesting date, any subsequent increase or decrease in the amount realised will be due to movements in the share price between the vesting date and the date of exercise. This increase or decrease in value is the result of an investment decision by the Executive Director and, as such, is not recorded as remuneration.



## Annual report on remuneration continued

Directors' interests in shares (audited) continued

## Non-Executive Directors' interests in shares

The interests of the Non-Executive Directors of the company in office during 2022 and their persons closely associated (PCA) are shown in the table below:

<table><tr><td rowspan="2"></td><td colspan="4">Total directors&#x27; interests as at(1)</td><td colspan="5">Share allocation plan for Non-Executive Directors</td></tr><tr><td>3 March 2023</td><td>31 December 2022 or date of retirement</td><td>Beneficial interests at 31 December 2022 or date of retirement(2)</td><td>Dividends reinvested after year end</td><td>31 December 2022 or date of retirement</td><td>Adjustments for share consideration(6)</td><td>Elected &amp; allocated during the year(3)</td><td>1 January 2022</td><td></td></tr><tr><td>Shares</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Sir Jonathan Symonds</td><td>69,045</td><td>68,316</td><td>33,925</td><td>728</td><td>34,391</td><td>(8,598)</td><td>15,273</td><td>27,716</td><td></td></tr><tr><td>Vindi Banga(6)</td><td>-</td><td>93,391</td><td>57,440</td><td>-</td><td>35,951</td><td>(8,987)</td><td>12,266</td><td>32,672</td><td></td></tr><tr><td>Dame Vivienne Cox(6)</td><td>-</td><td>12,252</td><td>-</td><td>-</td><td>12,252</td><td>(3,062)</td><td>4,767</td><td>10,547</td><td></td></tr><tr><td>Urs Rohner</td><td>19,710</td><td>19,317</td><td>798</td><td>392</td><td>18,519</td><td>(4,630)</td><td>6,722</td><td>16,427</td><td></td></tr><tr><td>ADS</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Elizabeth McKee Anderson</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td></td><td></td></tr><tr><td>Charles Bancroft</td><td>15,804</td><td>15,564</td><td>-</td><td>240</td><td>15,564</td><td>(2,617)</td><td>10,715</td><td>7,466</td><td></td></tr><tr><td>Dr Anne Beal</td><td>1,800</td><td>1,777</td><td>-</td><td>23</td><td>1,777</td><td>(233)</td><td>1,507</td><td>503</td><td></td></tr><tr><td>Dr Hal Barron</td><td>552,499</td><td>547,374</td><td>306,004</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td></td></tr><tr><td>Dr Hal Dietz</td><td>1,593</td><td>1,575</td><td>-</td><td>18</td><td>1,575</td><td>(164)</td><td>1,739</td><td>-</td><td></td></tr><tr><td>Lynn Elsenhans(5)</td><td>-</td><td>47,692</td><td>800</td><td>-</td><td>46,892</td><td>(11,722)</td><td>14,631</td><td>43,983</td><td></td></tr><tr><td>Dr Laurie Glimcher(6)</td><td>-</td><td>27,408</td><td>-</td><td>-</td><td>27,408</td><td>(6,430)</td><td>11,186</td><td>22,652</td><td></td></tr><tr><td>Dr Jesse Goodman</td><td>12,614</td><td>12,375</td><td>-</td><td>238</td><td>12,375</td><td>(2,846)</td><td>4,999</td><td>10,222</td><td></td></tr><tr><td>Dr Vishal Sikka</td><td>1,147</td><td>1,147</td><td>1,147</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td></td></tr></table>

1) Total directors' interests include beneficial interests and any notional shares/ADS received as all or part of their fees under the NED plan. Dividends received on notional shares/ADS under the NED Plan during the year and in January 2023 were converted into notional shares/ADS as at 12 January 2023.

2) Beneficial interests includes shares/ADS held by the Non-Executive Directors and their PCAs.

3) Notional shares/ADS allocated during the year under the NED plan includes (i) dividends reinvested during the year; and (ii) the reinvestment, on demerger, of an amount equivalent to the value of the Haleon plc shares/ADS attributable to the Non-Executive Directors' notional allocation of GSK plc shares/ADS (see note 4 below).

4) To align as closely as possible the treatment of Non-Executive Directors in respect of their NED plan allocations with those of shareholders on the demerger and share consolidation, NED plan allocations were adjusted as follows: (a) an amount equivalent to the value of the Haleon plc shares/ADS attributable to the Non-Executive Directors' notional holding of GSK plc shares/ADS was reinvested so as to increase those notional allocations of GSK plc shares/ADS on 18 July 2022; and (b) all notional GSK share/ADS allocations in the NED plan, including allocations arising under (a), were consolidated at a ratio of four new notional GSK shares/ADS for every five notional GSK shares/ADS held as at 18 July 2022.

5) Vindi Banga, Dame Vivienne Cox and Lynn Elsenhans all retired from the Board on 18 July 2022.

6) Dr Laurie Glimcher retired from the Board on 13 October 2022.



## Percentage change in remuneration of Directors

<table><tr><td rowspan="2"></td><td colspan="4">2022 percentage change</td><td colspan="4">2021 percentage change</td><td colspan="4">2020 percentage change</td></tr><tr><td>Salary/fee %</td><td>Benefits %</td><td>Bonus %</td><td>Salary/fee %</td><td>Benefits %</td><td>Bonus %</td><td>Salary/fee %</td><td>Benefit %</td><td>Bonus %</td><td>Salary/fee %</td><td>Benefits %</td><td>Bonus %</td></tr><tr><td>UK employees(1)</td><td>3.0</td><td>2.26</td><td>44.81</td><td>2.0</td><td>0.0</td><td>4.85</td><td>2.5</td><td>0.0</td><td>11</td><td></td><td></td><td></td></tr><tr><td>Executive Directors(2,3)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Emma Walmsley</td><td>3.0</td><td>(2.2)</td><td>38.2</td><td>2.0</td><td>(5.0)</td><td>94.6</td><td>8.0</td><td>(26.6)</td><td>(33.4)</td><td></td><td></td><td></td></tr><tr><td>Iain Mackay</td><td>3.0</td><td>20.2</td><td>32.4</td><td>2.0</td><td>56.1</td><td>94.2</td><td>5.6</td><td>11.5</td><td>(31.6)</td><td></td><td></td><td></td></tr><tr><td>Dr Hal Barron(4)</td><td>(29.2)</td><td>(26.2)</td><td>(66.2)</td><td>5.4</td><td>150.0</td><td>100.1</td><td>2.5</td><td>(91.2)</td><td>(34.9)</td><td></td><td></td><td></td></tr><tr><td>Non-Executive Directors(2,5,6)</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Sir Jonathan Symonds</td><td>0.0</td><td>233.3</td><td>-</td><td>0.0</td><td>50.0</td><td>-</td><td>201.7</td><td>0.0</td><td>-</td><td></td><td></td><td></td></tr><tr><td>Elizabeth McKee Anderson</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>&lt;ecel&gt;</td><td></td><td></td><td></td><td></td></tr></table>

(1) This table is provided in accordance with Schedule 8 of The Companies (Directors' Remuneration Policy and Directors' Remuneration Report) Regulations 2019. The UK employee population was considered to be the most relevant comparison as it most closely reflects the economic environment encountered by the majority of the Executive Directors.

(2) Percentage changes have been calculated based on the 2022 Total remuneration table on page 136 for Executive Directors and the 2022 Total fees table on page 153 for Non-Executive Directors. Increases in benefits for Non-Executive Directors are due to increased travel costs following the return to in-person meetings post-COVID-19.

(3) Further information on Executive Directors' salary and benefits can be found on page 137.

(4) Dr Hal Barron transitioned to a Non-Executive Director role on 1 August 2022.

(5) Fees of Non-Executive Directors include fees received as cash and in the form of shares or ADS under the terms of the NED plan.

(6) See page 123 for details of Non-Executive Director changes during the year.

## Directors and Senior Management

Further information is provided on compensation and interests of Directors and Senior Management as a group (the group). For this purpose, the group is defined as the Executive and Non-Executive Directors, other members of the GLT and the Company Secretary. For the financial year 2022, the following table sets out aggregate remuneration for the group for the periods during which they served in that capacity.

<table><tr><td>Remuneration for 2022</td><td>£</td></tr><tr><td>Total compensation paid</td><td>31,807,039</td></tr><tr><td>Aggregate decrease in accrued pension benefits (net of inflation)</td><td>(19,550)</td></tr><tr><td>Aggregate payments to defined contribution schemes</td><td>1,739,677</td></tr></table>

During 2022, members of the group were awarded shares and ADS under the company’s various LTI plans, as set out in the table below. To align the interests of Senior Management with those of shareholders, Executive Directors and GLT members are required to build and maintain significant holdings of shares in GSK over time. GLT members are required to hold shares to an equivalent multiple of two times their base salary, and must continue to satisfy these share ownership requirements for a minimum of 12 months after leaving GSK.

<table><tr><td rowspan="2">Awarded during 2022</td><td colspan="2">Awards</td><td colspan="2">Dividend reinvestment awards</td></tr><tr><td>Shares</td><td>ADS</td><td>Shares</td><td>ADS</td></tr><tr><td>Performance Share Plan</td><td>1,973,531</td><td>52,484</td><td>317,026</td><td>32,823</td></tr><tr><td>Deferred Investment Awards \( ^{(12)} \)</td><td>-</td><td>-</td><td>17,352</td><td>419</td></tr><tr><td>Share Value Plan \( ^{(2)} \)</td><td>16,380</td><td>-</td><td>-</td><td>-</td></tr></table>

1) Notional shares and ADS.

2) Executive Directors are not eligible to receive Deferred Investment Awards or participate in the Share Value Plan.



## Annual report on remuneration continued

## Directors and Senior Management continued

At 3 March 2023, the group and their PCAs had the following interests in shares and ADS of the company. Interests awarded under the various LTI plans are described in Note 44 to the financial statements, 'Employee share schemes' on pages 262 to 263.

<table><tr><td>Interests at 3 March 2023</td><td>Shares</td><td>ADS</td></tr><tr><td>Owned</td><td>2,533,721</td><td>409,464</td></tr><tr><td>Unexercised options</td><td>3,160</td><td>-</td></tr><tr><td>Deferred Annual Bonus Plan</td><td>842,660</td><td>118,293</td></tr><tr><td>Performance Share Plan</td><td>7,084,743</td><td>617,307</td></tr><tr><td>Deferred Investment Awards \( ^{(12)} \)</td><td>280,056</td><td>8,968</td></tr><tr><td>Share Value Plan \( ^{(2)} \)</td><td>68,345</td><td>5,740</td></tr></table>

1) Notional shares.

2) Executive Directors are not eligible to receive Deferred Investment Awards or participate in the Share Value Plan.

## Fees in respect of Executive Directors' external appointments

## CEO

Emma Walmsley is an independent non-executive director of Microsoft Corporation. During 2022, she received $360,208, of which $125,208 was delivered as cash and $235,000 as stock options under the Microsoft Corporation's Deferred Compensation Plan for its non-employee directors.

## CFO

On 11 July 2022, Iain Mackay became an independent non-executive director of National Grid plc. During 2022, he received £33,330 in fees which was delivered as cash.

## Payments to past Directors (audited)

No payments were made to past Directors in 2022 with the exception of the value of the deferred bonus and accrued dividends made to Simon Dingemans, as described on page 142 of the 2021 Annual Report.

## Payments for loss of office (audited)

No loss of office payments were made during 2022.

## How our Remuneration policy continues to reflect Provision 40 of the UK Corporate Governance Code (the Code)

## Clarity and simplicity

The remuneration arrangements for the Executive Directors are set out in a clear and simple way in the Remuneration policy. Whilst compiling and before finalising the Remuneration policy, the Committee consulted extensively with 40 shareholders representing 45% of our issued share capital, to ensure its full understanding of their views on the policy and transparency and clarity of the proposals and how they would be implemented. The fixed remuneration elements (salary, benefits and pension) are closely aligned with wider workforce arrangements and our pay for performance plans (Annual Bonus and Long-term incentive) reward delivery of financial, strategic and ESG objectives in the short and long term.

## Risk

In line with the Code, we operate both deferral and post-vesting holding arrangements, in addition to operating malus and clawback provisions. The Committee retains discretion to adjust award outcomes (to zero if appropriate) should it consider the payout determined does not appropriately reflect the overall position and performance of the company.

## Predictability and proportionality

Our Remuneration policy defines maximum limits on the total Annual Bonus and Long-term incentive opportunities, and payouts under these elements are linked to fulfilment of performance conditions that support the company’s publicly stated ambitions. Through its implementation, maximum reward under our short- and long-term plans are only achievable for material outperformance against our stated ambitions.

## Alignment to culture

GSK’s purpose, strategy and culture continue to be directly reflected in the performance conditions set under the Annual Bonus and Long-term incentive. In particular, we have introduced an ESG measure in both our short- and long-term plans. These currently reinforce our diversity, equity and inclusion aspirations for 2025, and our Nature Net Positive and Climate Net Zero ambition by 2030. Our Share Ownership Requirements strengthen the focus on our strategic aims, and ensure alignment with the interests and experiences of shareholders, both during and after employment.
The Committee believes the Remuneration policy has been operated as intended in terms of company performance and quantum during 2022.



# 2022 Remuneration policy summary

The company’s Remuneration policy was approved on 4 May 2022 at GSK’s Annual General Meeting and has operated as intended since its approval. The full policy is available at gsk.com in the Investors section. Two administrative amendments to the company’s Remuneration policy are being proposed for binding shareholder approval at GSK’s 2023 Annual General Meeting, as described on page 163.

## Executive Director Remuneration policy

Salary

To provide a core reward for the role. Set at a level appropriate to secure and retain high calibre individuals needed to deliver the Group’s strategic priorities.

## Operation

Individual’s role, experience, performance and independently sourced data for relevant comparator groups considered when determining salary levels.

Salary increases typically take effect in the first quarter of each year.

Salaries are normally paid in the currency of the Executive Director’s home country.

## Opportunity

There is no formal maximum limit and, ordinarily, salary increases will be broadly in line with the average increases for the wider GSK workforce.

However, increases may be higher to reflect a change in the scope of the individual’s role, responsibilities or experience. Salary adjustments may also reflect wider market conditions in the geography in which the individual operates.

Details of current salary levels are set out in the Annual report on remuneration.

## Performance measures

The overall performance of the individual is a key consideration when determining salary increases.

## Benefits

Levels are set to recruit and retain high calibre individuals to execute the business strategy.

## Operation

Executive Directors are eligible to receive benefits in line with the policy for other employees which may vary by location. These include, but are not limited to, car allowances, healthcare, life assurance/death in service (where not provided as part of the individual’s pension arrangements), personal financial advice and contractual post-retirement benefits. In line with the policy for other employees, Executive Directors may be eligible to receive overseas relocation allowances and international transfer-related benefits when required. Executive Directors in the UK are also eligible to participate in all-employee share schemes (e.g. Share Save and Share Reward plans), under which they are subject to the same terms as all other employees.

In order to recognise the high business travel requirements of the role, Executive Directors are also entitled to car travel and exceptionally may be accompanied by their spouse/partner on business trips. Other benefits include expenses incurred in the ordinary course of business, which are deemed to be taxable benefits on the individual.
Where an Executive Director is based outside the UK, but is required to travel to the UK to fulfil the responsibilities of their role and to attend Board Meetings, they may be subject to tax on their business travel expenses to and from the UK and on the provision of any accommodation in the UK. Although in reality it represents a business expense, the tax treatment requires that their travel and accommodation expenses are then included as benefits. Because of the business context, the tax liabilities will be covered by the company on a grossed-up basis.

Benefit provision is tailored to reflect market practice in the geography in which the Executive Director is based and different policies may apply if current or future Executive Directors are based in a different country.

## Opportunity

There is no formal maximum limit as benefits costs can fluctuate depending on changes in provider cost and individual circumstances.

Details of current benefits and costs are set out in the Annual report on remuneration.

## Performance measure

None



## 2022 Remuneration policy summary continued

Executive Director Remuneration policy continued

## Pension

Pension arrangements provide a competitive level of retirement income.

Pension arrangements provide a competitive level of retirement income.

## Operation

Pension arrangements are structured in accordance with the plans operated in the country in which the individual is likely to retire. Where the individual chooses not to become a member of the pension plan, cash in lieu of the relevant pension contribution is paid instead. Executive Directors in the UK are entitled either to join the defined contribution pension plan or to receive a cash payment in lieu of pension contribution.

Where an individual is a member of a GSK legacy defined benefit plan, a defined contribution plan or an alternative pension plan arrangement and is subsequently appointed to the Board, he or she may remain a member of that plan.

## Opportunity

The policy for all current Executive Directors is:

## UK:

– 20% of base salary contribution to defined contribution plan and further 5% in matched contributions subject to any relevant cap and in line with implementation principles for other members of the plan; and

– 20% of base salary as a cash payment in lieu of pension contribution for the portion above the relevant cap;

or

– 20% of base salary as a cash payment in lieu of pension contribution.

From 1 January 2023, any current UK Directors who are still in role will have their pension arrangements aligned to new Executive Directors' arrangements as follows.

From 1 January 2023, any current UK Directors who are still in role will have their pension arrangements aligned to new Executive Directors' arrangements as follows.
Any new Executive Directors in the UK will receive from date of appointment:

– 7% of base salary contribution to defined contribution plan and further 3% in matched contributions subject to any relevant cap and in line with implementation principles for other members of the plan; and

– 7% of base salary as a cash payment in lieu of pension contribution for the portion above the relevant cap;

or

– 7% of base salary as a cash payment in lieu of pension contribution.

## US \( ^{0} \) :

– Supplemental Cash Balance pension plan, providing annual contribution of 38% of base salary, less 5% of total base salary and bonus (net of the bonus deferred under the DABP) \( ^{3} \) .

– GSK 401(k) plan \( ^{1} \)  and the ESSP \( ^{1} \)  with core contributions of 7% of salary and bonus \( ^{2} \)  and matched contributions of 4% of salary and bonus \( ^{2} \) .

From 1 January 2023, any current US Executive Directors who are still in role will have their pension arrangements aligned to new Executive Directors' arrangements as follows.

Any new Executive Directors in the US will receive from date of appointment:

– GSK 401(k) plan \( ^{1} \)  and the ESSP \( ^{1} \)  with core contributions of 7% of salary and bonus \( ^{2} \)  and matched contributions of 4% of salary and bonus \( ^{2} \) .

## Global:

– Eligible for appropriate equivalent arrangement not in excess of the US/UK arrangements.

## Performance measures

None.

(1) In the event of any change to the plans operated in the US, a similar treatment would be provided under any successor arrangements introduced within the market
(2) Less bonus deferred under the DABP

(3) The 5% offset is equal to the contribution to the 401(k) and ESSP which was moved from the pension plans, in line with the wider US workforce, from 1 January 2021

## Annual Bonus

To incentivise and recognise execution of the business strategy on an annual basis. Rewards the achievement of stretching annual financial, strategic and operational measures.

## Operation

Financial, operational and business targets are set at the start of the year by the Committee and bonus levels are determined by the Committee based on performance against those targets.

Strategic and operational measures are set at the start of the year by the Committee and performance against those measures is assessed by the Committee.

Executive Directors are required to defer part of any bonus earned into shares, or ADS as appropriate, for three years. 50% of the equivalent of the first 200% of salary is deferred, and any portion in excess of 200% is deferred in full. Deferred bonus shares are eligible for dividend equivalents up to the date of vesting.
The Committee may adjust the formulaic vesting outcome (either up or down) to ensure that the overall outcome reflects underlying business performance over the vesting period. Clawback and/or malus provisions apply as described on page 147 of the 2021 Annual Report.

## Opportunity

The maximum bonus opportunity for Executive Directors is 300% of salary. Below 99% of target performance, the bonus payout on the financial measures will be nil. For target performance, the bonus payout will be 100% of salary.



## 2022 Remuneration policy summary continued

## Executive Director Remuneration policy continued

## Performance measures

Based on a combination of financial targets and individual/strategic and ESG performance objectives, with the majority of the bonus assessed against the financial measures. The weighting between different measures will be determined each year according to business priorities. Further details, including the measures to be used in the financial year, are provided in the Annual report on remuneration.

## Selection of Annual Bonus measures

The Annual Bonus is designed to drive the achievement of GSK’s annual financial, strategic and operational measures. For this reason the majority of the Annual Bonus opportunity is based on a formal review of performance against stretching financial targets, with the remainder of the bonus subject to assessment of individual performance against the key strategic and operational measures which are aligned to the company’s key objectives for that financial year and/or assessment of performance against ESG targets.

The Annual Bonus financial targets are set by reference to internal budget and external consensus targets.

<table><tr><td>Performance Share Plan (PSP)</td><td>To incentivise and recognise delivery of the longer term business priorities, financial growth and increases in shareholder value compared to other pharmaceutical companies. In addition, to provide alignment with shareholder interests, a retention element, to encourage long-term shareholding and discourage excessive risk taking.</td></tr></table>

## Operation

Conditional awards are made annually with vesting dependent on the achievement of performance conditions over three years and are subject to an additional two-year holding period. PSP targets are set by reference to internal budget and external consensus targets.

Awards are eligible for dividend equivalents up to the date of vesting and release.

The Committee may adjust the formulaic vesting outcome (either up or down) to ensure that the overall outcome reflects underlying business performance over the vesting period.

Clawback and/or malus provisions apply as described on page 147 of the 2021 Annual Report.

## Selection of Long-term incentive measures

The Committee selects performance measures which focus Executive Directors' long-term remuneration on the delivery of GSK's key strategic priorities over the longer term. In addition to setting robust targets, the Committee has implemented a number of safeguards to ensure the targets are met in a sustainable way and performance reflects genuine achievement against targets and therefore represents the delivery of value for shareholders.

For each performance measure, the impact of any acquisition or divestment will be quantified and adjusted for after the event.

## Opportunity

The normal maximum award limits that may be granted under the PSP to an individual in any one year are set out in the table below:

<table><tr><td></td><td>% of salary</td></tr><tr><td>CEO</td><td>600</td></tr><tr><td>CFO</td><td>400</td></tr><tr><td>Other Executive Directors</td><td>500</td></tr></table>

## Performance measures

Based on a combination of financial, share price related and strategic and ESG performance conditions which are aligned to the company’s strategic plan. For all measures, 25% of awards will vest at threshold performance. Further details, including the performance targets attached to the PSP in respect of each year, and the weightings of the targets for the 2022 PSP awards are provided in the Annual report on remuneration.

Any major adjustment in the calculation of performance measures will be disclosed to shareholders on vesting.

The Audit & Risk Committee chair and other members, who are also members of the Remuneration Committee, provide input on the Audit & Risk Committee’s review of the Group’s performance and oversight of any risk factors relevant to remuneration decisions.

Details of the rationale behind the performance measures selected and how they are calculated are set out in the 2021 Annual report on remuneration.



## 2022 Remuneration policy summary continued

Executive Director Remuneration policy continued

## Share Ownership Requirements
No change

To align the interests of Executive Directors with those of shareholders, they are required to build and maintain significant holdings of shares in GSK over time. The requirements for each Executive Director are as follows:

<table><tr><td></td><td>% salary</td></tr><tr><td>CEO</td><td>650</td></tr><tr><td>Other Executive Directors</td><td>300</td></tr></table>

As a minimum, Executive Directors are required to maintain 100% of their share ownership requirements to the end of the first year following retirement from the company and 50% to the end of the second year.

For details of our policy on clawback and malus, approach to recruitment remuneration, loss of office and termination payments, please refer to the full 2022 Remuneration policy report on pages 144 to 152 of the 2021 Annual Report, available on gsk.com in the Investors section

## Differences between Remuneration policy for Executive Directors and other employees

When setting remuneration for the Executive Directors, the Committee considers the company’s strategic priorities, prevailing market conditions for global talent, the competitive environment (through comparison with the remuneration of executives at companies of similar size, complexity and international reach) and the positioning and relativities of pay and employment conditions across the broader GSK workforce.

In particular, the Committee considers the range of base salary rises for the workforces of those parts of GSK where the Executive Directors are employed. This is considered to be the most relevant comparison as these populations reflect most closely the economic environments encountered by the individuals.

The same principles apply to the Remuneration policy for Executive Directors and other employees although the remuneration offered to Executive Directors under this policy has a stronger emphasis on performance-related pay than that offered to other employees of the Group.

– Salary and benefits (including pension) are tailored to the local market

– The Annual Bonus plan applies to the wider employee population and is based on business performance

– A combination of performance-related and restricted share plans apply to the wider employee population

– All-employee share plans are available to employees in the UK, including the HM Revenue & Customs approved UK Share Save and Share Reward plans
While employees are not directly consulted in respect of the Remuneration policy, Urs Rohner, the Committee Chair, meets with senior HR representatives from across the business to review employee feedback. Dame Vivienne Cox, an Independent Non-Executive Director, engages with employees on various topics, including remuneration, in her role as Workforce Engagement Director. Board members engage with employees around during Board meetings where they are encouraged to share their views on the company, management and remuneration.

Since approval of the Policy in May 2022, the Board has evolved its approach to workforce engagement. Further details are provided on page 115.

In the wider organisation, we have aligned our performance and reward systems with our Innovation, Performance and responsible business priorities and with a culture anchored in purpose and performance. Our performance system evaluates employees on both ‘what’ they need to do and ‘how’ they do it. Also, for our most senior people we disincentivise unethical working practices using a clawback mechanism that allows us to recover performance-related pay.



## Non-Executive Director Remuneration policy 2022

<table><tr><td colspan="3">Non-Executive Directors&#x27; fees</td></tr><tr><td>Element</td><td>Purpose and link to strategy</td><td>Operation</td></tr><tr><td>Chair&#x27;s fees</td><td>To provide an inclusive flat rate fee that is competitive with those paid by other companies of equivalent size and complexity subject to the limits contained in GSK&#x27;s Articles of Association.</td><td>There is no formal maximum. However, fees are reviewed annually and set by reference to a review of the Chair&#x27;s performance and independently sourced market data. The Committee is responsible for evaluating and making recommendations to the Board on the fees payable to the Chair. The Chair does not participate in discussions in respect of their fees.</td></tr><tr><td>Basic fees</td><td>As above</td><td>There is no formal maximum. As with the Chair, fees are reviewed annually and set by reference to independent sources of data. The Chair and CEO are responsible for evaluating and making recommendations to the Board on the fees payable to the company&#x27;s Non-Executive Directors.</td></tr><tr><td>Fee payment</td><td>Alignment with shareholders</td><td>Fees are paid in cash. Non-Executive Directors (including the Chair) were required to invest at least 25% of their total net fees in shares or ADS of the company. The company has since replaced the 25% minimum investment requirement with a minimum share or ADS ownership requirement of at least one times the Non-Executive Director&#x27;s (or Chair&#x27;s) gross annual standard fees to be retained until their retirement from the Board. An administrative amendment to this section of the Remuneration policy is proposed for binding shareholder approval at the 2023 AGM as described on page 163.</td></tr><tr><td>Supplemental fees</td><td>To compensate Non-Executive Directors (other than the Chair) for taking on additional Board responsibilities or undertaking intercontinental travel.</td><td>Additional fees for the Senior Independent Director, Committee Chairs, Scientific and Medical Experts, the Workforce Engagement Director role and intercontinental travel. The company has the authority to pay an additional fee, up to the equivalent of the Committee Chair supplement to a Non-Executive Director, should the company require significant additional time commitment in exceptional or unforeseen circumstances. The company has the authority to pay an additional fee of up to £200,000 to Non-Executive Directors (excluding the Chair) who are members of the Science Committee for undertaking additional responsibilities on behalf of GSK and to support R&amp;D.</td></tr><tr><td>Benefits</td><td>To facilitate execution of responsibilities and duties required by the role.</td><td>Travel and subsistence costs for Non-Executive Directors are incurred in the normal course of business in relation to meetings on Board and Committee matters and other GSK-hosted events. For overseas-based Non-Executive Directors, this includes travel to meetings in the UK. In the event it is necessary for business purposes, whilst not normal practice, Non-Executive Directors may be accompanied by their spouse or partner to these meetings or events. The costs associated with the above are all met by the company and, in some instances, they are deemed to be taxable and therefore treated as benefits for the Non-Executive Director.</td></tr></table>

## Approach to recruitment remuneration

The following policy and principles apply to the roles of Chair and Non-Executive Director. It seeks to ensure alignment with shareholders through the requirement to invest in company shares and ADS.

## Chair

Fees will be set at a level that is competitive with those paid by other companies of equivalent size and complexity. Fees will be paid partly in shares.

## Loss of office

## Non-Executive Directors

Fee levels for new Non-Executive Directors will be set on the same basis as for existing Non-Executive Directors of the company, subject to local laws and regulations.

In the event of a Non-Executive Director with a different role and responsibilities being appointed, fee levels will be benchmarked and set by reference to comparable roles in companies of equivalent size and complexity.

The Chair and other Non-Executive Directors are not entitled to receive any payments in respect of fees for loss of office when they retire or step down from the Board.



# Administrative amendments to the 2022 Remuneration policy

## Proposed amendments

Two administrative amendments to the company’s 2022 Remuneration policy (Policy), which was approved at last year’s AGM, are being proposed as ordinary resolutions for binding shareholder approval at the AGM on 3 May 2023. The Policy is subject to renewal in respect of remuneration for 2025. Given that these changes are purely administrative, a full consultation with employees was not undertaken on these amendments.

## Non-Executive Directors’ minimum share ownership requirement

The Non-Executive Directors section of the 2022 Policy includes a requirement for Non-Executive Directors (including the Chair) to invest a minimum of 25% of their net basic fees in shares or ADS of the company. The Policy also states that, should the company replace this requirement, any shares or ADS previously acquired in accordance with this 25% minimum investment requirement would: (i) continue to be held under those previous arrangements, (ii) count towards any expected minimum ownership requirement; and (iii) be delivered or released following the Non-Executive Director’s (or Chair’s) retirement from the Board.

The company has since replaced the 25% minimum investment requirement, as set out in the 2021 Annual Report, with a minimum share or ADS ownership requirement of at least one times the Non-Executive Director’s (or Chair’s) gross Annual Standard Fees to be retained until their retirement from the Board.

Shareholder approval will be sought to amend the Non-Executive Directors section of the Policy to allow the shares or ADS acquired under the previous 25% minimum investment requirement to be delivered or released to the Non-Executive Director (or Chair) at such time as the Board (excluding that Non-Executive Director or the Chair) considers appropriate (subject to any applicable tax withholding), rather than continue to be held under the previous arrangements.

This is subject to the Non-Executive Directors (or the Chair) undertaking to the company to hold such shares or ADS in the company until they retire from the Board. This will give the company greater operational flexibility, and reduce the administrative burden, in the implementation of the new minimum share ownership requirement whilst ensuring that the Non-Executive Directors (and the Chair) continue to maintain a meaningful and prudent level of investment which aligns their interests with shareholders.

## Clawback and malus

Shareholder approval will be sought to amend the Clawback and malus section of the Policy to expressly refer to the company’s ability to update its clawback policies, and to make disclosures in relation to clawback, in each case as required by applicable regulatory requirements, including the recently adopted Securities and Exchange Commission (SEC) rules (and the New York Stock Exchange (NYSE) listing standards implementing those rules) on clawback in the event of an accounting restatement.

The SEC adopted new rules, in late 2022, which require the NYSE (amongst others) to adopt new listing standards that require a listed company to clawback erroneously awarded incentive-based compensation whenever it is required to prepare an accounting restatement that corrects an error in a previously issued financial statement, or that would result in a material misstatement if the error were corrected in the current period or left uncorrected in the current period. These new listing standards are expected to become effective in late 2023. GSK shares are listed and traded on the NYSE in the form of ADS and GSK will, as a result, be subject to the new listing standards which are expected to require clawback in circumstances that are wider than those currently provided for by the company’s policies. The related SEC rules will also require GSK to make certain disclosures in connection with its clawback policy in its annual report on Form 20-F (including filing a copy of the clawback policy with the SEC).

The proposed changes to the ‘Clawback and malus’ element of the Policy are intended to ensure clarity by expressly referring to the company’s ability to update its clawback policies, and to make disclosures in relation to clawback, in each case as required by applicable regulatory requirements (including the SEC and NYSE requirements). The Committee will update its current recoupment policies as required to meet the new NYSE listing standards and the related SEC disclosure requirements once they become effective.



## Operation and scope of Remuneration policy

The Remuneration policy (Policy) is set out on pages 144 to 152 of the 2021 Annual Report and it is intended that the Policy for GSK’s Executive and Non-Executive Directors will operate for a period of three years from the date of approval at the company’s Annual General Meeting on 4 May 2022.

The Committee wrote the Policy principally in relation to the remuneration arrangements for the Executive Directors, whilst taking into account the possible recruitment of a replacement or an additional Executive Director during the operation of the Policy. The Committee intends the Policy to operate for the period set out above in its entirety. However, it may after due consideration seek to change the Policy during this period, but only if it believes it is appropriate to do so for the long-term success of the company, after consultation with shareholders and having sought shareholder approval at a general meeting.

The Committee reserves the right to make any remuneration payments and/or payments for loss of office (including exercising any discretions available to it in connection with such payments) notwithstanding that they are not in line with the Policy where the terms of the payment were agreed:

(i) before the AGM on 7 May 2014 (the date the company’s first shareholder-approved Directors’ Remuneration policy came into effect);
(ii) before the Policy came into effect, provided that the terms of the payment were consistent with the shareholder-approved Remuneration policy in force at the time they were agreed; or

(iii) at a time when the relevant individual was not a Director of the company and, in the opinion of the Committee, the payment was not in consideration for the individual becoming a Director of the company. For these purposes ‘payments’ includes the Committee satisfying awards of variable remuneration and, in relation to an award over shares or ADS, the terms of the payment are ‘agreed’ at the time the award is granted.

Performance Share Plan (PSP) awards are subject to the terms of the PSP plan rules under which the award has been granted. The Committee may adjust or amend awards only in accordance with the provisions of the plan rules. This includes making adjustments to reflect one-off corporate events, such as a change in the company’s capital structure.

The Committee may also make minor amendments to the Policy (for regulatory, exchange control, tax or administrative purposes or to take account of a change in legislation) without obtaining shareholder approval for such amendments.

## Basis of preparation

The Annual report on remuneration has been prepared in accordance with the Companies Act 2006 and The Large and Medium-sized Companies and Groups (Accounts and Reports) (Amendment) Regulations 2013 (the Regulations). In accordance with the Regulations, the following parts of the Annual report on remuneration are subject to audit: total remuneration figures for Executive Directors including further details for each element of remuneration (salary, benefits, pension, Annual Bonus and Long-term incentive awards); Non-Executive Directors’ fees and emoluments received in the year; Directors’ interests in shares, including interests in GSK share plans; payments to past Directors; payments for loss of office; and share ownership requirements and holdings, for which the opinion thereon is expressed on page 181. The remaining sections of the Annual report on remuneration are not subject to audit nor are the pages referred to from within the audited sections.
The Annual report on remuneration has been approved by the Board of Directors and signed on its behalf by:

Urs Rohner
Remuneration Committee Chair
9 March 2023



## Financial
statements

<table><tr><td colspan="2">In this section</td></tr><tr><td>Directors&#x27; statement of responsibilities</td><td>166</td></tr><tr><td>Independent Auditor&#x27;s report</td><td>168</td></tr><tr><td>Financial statements</td><td>182</td></tr><tr><td>Notes to the financial statements</td><td>186</td></tr><tr><td>Financial statements of GSK plc prepared under UK GAAP</td><td>268</td></tr></table>



# Directors’ statement of responsibilities

The Directors are responsible for preparing the Annual Report, the Remuneration report and the Group and parent company financial statements in accordance with applicable law and regulations.

UK company law requires the Directors to prepare financial statements for each financial year. The Directors are required to prepare the Group consolidated financial statements in accordance with International Accounting Standards in conformity with the requirements of the Companies Act 2006 and the International Financial Reporting Standards (IFRS) as issued by the International Accounting Standards Board (IASB). The Directors have elected to prepare the parent company financial statements in accordance with United Kingdom Accounting Standards and applicable law (United Kingdom Generally Accepted Accounting Practice) (Financial Reporting Standard 101 Reduced Disclosure Framework). Under company law the Directors must not approve the financial statements unless they are satisfied that they give a true and fair view of the state of affairs of the Group and its profit or loss for that period. In preparing the financial statements, the Directors are

required to:

– select suitable accounting policies and then apply them consistently;

– make judgements and accounting estimates that are reasonable and prudent;

– state that the Group financial statements comply with IFRS, as issued by the IASB and in conformity with the requirements of the Companies Act 2006;

– state with regard to the parent company financial statements that applicable UK Accounting Standards have been followed, subject to any material departures disclosed and explained in the parent company financial statements; and

– prepare the financial statements on a going concern basis unless it is inappropriate to presume that the Group and the parent company will continue in business.

In preparing the Group financial statements, International Accounting Standard 1 requires that directors properly select and apply accounting policies; present information, including accounting policies, in a manner that provides relevant, reliable, comparable and understandable information; provide additional disclosures when compliance with the specific requirements in IFRS Standards are insufficient to enable users to understand the impact of particular transactions, other event and conditions on the entity's financial position and financial performance; and make an assessment of the company's ability to continue as a going concern.
The Directors are responsible for keeping adequate accounting records that are sufficient to show and explain the company's transactions and disclose with reasonable accuracy at any time the financial position of the Group and to enable them to ensure that the Group financial statements and the Remuneration report comply with the Companies Act 2006. They are also responsible for safeguarding the assets of the Group and hence for taking reasonable steps for the prevention and detection of fraud and other irregularities.

The Group financial statements for the year ended 31 December 2022, comprising principal statements and supporting notes, are set out in the 'Financial statements' on pages 182 to 267 of this report. The parent company financial statements for the year ended 31 December 2022, comprising the balance sheet and the statement of changes in equity for the year ended 31 December 2022 and supporting notes, are set out on pages 268 to 272.

The responsibilities of the auditor in relation to the financial statements are set out in the Independent Auditor’s report on pages 168 to 181.

The financial statements for the year ended 31 December 2022 are included in the Annual Report, which is published in printed form and made available on our website. The Directors are responsible for the maintenance and integrity of the corporate and financial information included on the company's website. Legislation in the United Kingdom governing the preparation and dissemination of financial statements may differ from legislation in other jurisdictions.

Each of the current Directors, whose names and functions are listed in the Corporate Governance section of the Annual Report 2022 confirms that, to the best of his or her knowledge:

– the Group financial statements, which have been prepared in accordance with IFRS, as issued by the IASB and in conformity with the requirements of Companies Act 2006, give a true and fair view of the assets, liabilities, financial position and profit of the Group;

– the Strategic report and risk sections of the Annual Report, which represent the management report, include a fair review of the development and performance of the business and the position of the company and the Group taken as a whole, together with a description of the principal risks and uncertainties that it faces; and

– the annual report and financial statement, taken as a whole, are fair, balanced and understandable and provide the information necessary for shareholders to assess the company’s position and performance, business model and strategy.



## Directors’ statement of responsibilities continued

## Disclosure of information to auditor

The Directors in office at the date of this Annual Report have each confirmed that:

– so far as he or she is aware, there is no relevant audit information of which the company’s auditor is unaware; and

– he or she has taken all the steps that he or she ought to have taken as a Director to make himself or herself aware of any relevant audit information and to establish that the company’s auditor is aware of that information.

This confirmation is given and should be interpreted in accordance with the provisions of section 418 of the Companies Act 2006.

## Going concern basis

Pages 66 to 95 and pages 55 to 61 contain information on the performance of the Group, its financial position, cash flows, net debt position, borrowing facilities and climate related risks. Further information, including Treasury risk management policies, exposures to market and credit risk and hedging activities, is given in Note 44 to the financial statements, 'Financial instruments and related disclosures'. Having assessed the principal risks and other matters considered in connection with the viability statement, the Directors considered it appropriate to adopt the going concern basis of accounting in preparing the financial statements.

## Internal control

The Board, through the Audit & Risk Committee, has reviewed the assessment of risks and the internal control framework that operates in GSK and has considered the effectiveness of the system of internal control in operation in the Group for the year covered by this Annual Report and up to the date of its approval by the Board of Directors. Further detail on the review of internal controls is set out in the Governance report on page 125.

## The 2018 UK Corporate Governance Code

The Board considers that GSK plc applies the principles and complies with the provisions of the UK Corporate Governance Code maintained by the Financial Reporting Council, as described in the Corporate Governance section on pages 97 to 131. The Board further considers that the Annual Report, taken as a whole, is fair, balanced and understandable, and provides the information necessary for shareholders to assess the Group’s position and performance, business model and strategy.

As required by the Financial Conduct Authority’s Listing Rules, the auditor has considered the Directors’ statement of compliance in relation to those points of the UK Corporate Governance Code which are specified for their review.

## Annual Report

The Annual Report for the year ended 31 December 2022, comprising the Report of the Directors, the Remuneration report, the Financial statements and Additional information for investors, has been approved by the Board of Directors and signed on its behalf by

Sir Jonathan Symonds
Chair
9 March 2023



# Independent Auditor’s report to the members of GSK plc

## Report on the audit of the financial statements

## 1. Opinion

In our opinion:

– The financial statements of GSK plc (the 'Parent company') and its subsidiaries (the 'Group') give a true and fair view of the state of the Group's and of the Parent company's affairs as at 31 December 2022 and of the Group's profit for the year then ended;

– The Group financial statements have been properly prepared in accordance with United Kingdom adopted international accounting standards and International Financial Reporting Standards (IFRSs) as issued by the International Accounting Standards Board (IASB);

– The Parent company financial statements have been properly prepared in accordance with United Kingdom Generally Accepted Accounting Practice including FRS 101 “Reduced Disclosure Framework”; and

– The financial statements have been prepared in accordance with the requirements of the Companies Act 2006.

We have audited the financial statements which comprise the:

## Group

– Consolidated balance sheet as at 31 December 2022;

– Consolidated income statement for the year then ended;

– Consolidated statement of comprehensive income for the year then ended;

– Consolidated statement of changes in equity for the year then ended;

– Consolidated cash flow statement for the year then ended; and

– Notes 1 to 47 to the financial statements, which includes the accounting principles and policies.

## Parent company

– Balance sheet as at 31 December 2022;

– Statement of changes in equity for the year then ended; and

– Notes A to M to the financial statements, which includes the accounting principles and policies.

The financial reporting framework that has been applied in the preparation of the Group financial statements is applicable law, United Kingdom adopted international accounting standards and IFRSs as issued by the IASB. The financial reporting framework that has been applied in the preparation of the Parent company financial statements is applicable law and United Kingdom Accounting Standards, including FRS 101 “Reduced Disclosure Framework” (United Kingdom Generally Accepted Accounting Practice).

## 2. Basis for opinion

We conducted our audit in accordance with International Standards on Auditing (UK) (ISAs (UK)) and applicable law. Our responsibilities under those standards are further described in the auditor's responsibilities for the audit of the financial statements section of our report.

We are independent of the Group and the Parent company in accordance with the ethical requirements that are relevant to our audit of the financial statements in the UK, including the Financial Reporting Council’s (the ‘FRC’s’) Ethical Standard as applied to listed public interest entities, and we have fulfilled our other ethical responsibilities in accordance with these requirements. We confirm that we have not provided any non-audit services prohibited by the FRC’s Ethical Standard to the Group or the Parent company, as noted in the Audit & Risk Committee report within the Corporate Governance section of the Annual Report on page 124 and the disclosure provided in Note 8 regarding fees payable to the Group’s auditor.

We believe that the audit evidence we have obtained is sufficient and appropriate to provide a basis for our opinion.

## 3. Audit scope and execution

We structured our approach to the audit to reflect how the Group is organised as well as ensuring our audit was both effective and risk focused. Our audit approach can be summarised into the following areas that enabled us to obtain the evidence required to form an opinion on the Group and Parent company financial statements:

– Risk assessment and audit planning at a Group level. The central control and common systems throughout most of the Group enabled us to structure our audit centrally. The use of data analytic tools allowed for a more detailed understanding of the flow of transactions, enabling us to focus our risk assessment and design targeted audit testing procedures. Our risk assessment procedures considered, amongst other factors, the impact of the global pandemic and climate change on the account balances, disclosures and company practices. We appointed partners from the Group audit team to lead the global audit of the revised operating segments (commercial operations, research & development and consumer healthcare), in addition to partners responsible for the component and legal entity audits in each country. These segment partners met regularly with senior segment management to understand the strategy, performance and other matters which arose throughout the year that could have impacted the financial reporting. Our risk assessment and audit planning included consideration of the separation of the consumer healthcare business from the Group on 18 July 2022. In addition, we held regular meetings with members of the Internal Audit, the internal Legal Counsel and the Global Ethics & Compliance teams to understand their work and to review their reports to enhance our risk assessment;



## Independent Auditor’s report continued

Report on the audit of the financial statements continued

– Audit work performed at global shared service centres.
A significant amount of the Group’s operational processes that cover financial reporting is undertaken in shared service centres. Our Group audit team included senior individuals responsible for each of the global processes who coordinated our audit work at the shared service centres in-scope for the Group audit to enable us to develop a good understanding of the end-to-end processes that supported material account balances, classes of transactions and disclosures within the Group financial statements. We then evaluated the effectiveness of internal controls over financial reporting for these processes and considered the implications for the remainder of our audit work;

– Audit work executed at component level and individual legal entities. The following components were subject to audit procedures as well as the assessment of the effectiveness of internal controls over financial reporting, which include in-scope entities in the consumer healthcare segment prior to demerger: Australia; Belgium; Canada; China; France; Germany; Italy; Japan; Spain; United Kingdom; and the United States. The Group audit team was in active dialogue throughout the audit with the component audit teams responsible for the audit work under the direction and supervision of the Group audit team. This included determining whether the work was planned and performed in accordance with the overall Group audit strategy and the requirements of our Group audit instructions to the components. We have planned and performed site visits of components where overseas travel restrictions allowed. To satisfy ourselves that our oversight and supervision was appropriate we performed reviews of audit working papers, increased the frequency and length of those reviews depending on the significance and risk of the component and continued to attend the planning and clearance meetings of components;

– Audit procedures undertaken at a Group level and on the parent company. In addition to the above, we also performed audit work on the Group and Parent company financial statements, including but not limited to the consolidation of the Group’s results, the preparation of the financial statements, certain disclosures within the Directors’ Remuneration report, litigation provisions and exposures in addition to entity level and oversight controls relevant to financial reporting. All components or legal entities with annual revenue greater than 1.8% (2021-1.8%) of the total Group revenue were included in our audit scope. The components or legal entities not covered by our audit scope were subject to analytical procedures to confirm our conclusion that there were no significant risks of material misstatement in the aggregated financial information; and

– Internal controls testing approach. We tested the effectiveness of internal controls over financial reporting across all in-scope entities, including in the consumer healthcare segment pre-demerger, and entity level controls at the Group level. Common systems allowed for relevant IT controls to be tested centrally across all components. The consumer healthcare demerger impacted relevant IT systems prior to the demerger which was reflected in the scope of our IT testing. We were able to place reliance on controls where planned and it was more efficient. Notwithstanding the IT controls deficiencies disclosed in the key audit matters section of this report, mitigating controls existed which allowed us to continue to take reliance on controls where planned.

Our audit scope addressed 79% (2021: 73%) of the Group’s revenue, 91% (2021: 76%) of the Group’s profit before tax and 86% (2021: 85%) of the Group’s total assets.

## The impact of climate change on our audit

Climate change has the potential to impact the Group in a number of ways as set out in the strategic report on pages 55 to 62 of the Annual Report and Notes 17, 19 and 20 of the financial statements. The Group has set out their environmental goals under the Paris Climate Accord to have a net zero impact on climate and a net positive impact on nature by 2030.

In the planning of our audit, we have considered the potential impact of climate change on the Group’s business and its financial statements.

We have sought to understand the Group’s identification and assessment of the potential impacts of climate change, how these risks influence the Group’s strategy and their implications on the financial statements.

The Group’s assessment focused on the impacts of more frequent extreme weather conditions, water scarcity, changes in the political landscape and media focus which has the propensity to cause changes in consumer and market behaviour; volatility in the costs and availability of materials and resources that could impact future financial performance and asset valuations.

In consultation with our climate change specialists, we:

– Conducted detailed risk assessment procedures across all in-scope balances and transactions to determine any risks of material misstatement in the financial statements by applying the expected impact of climate change to our understanding of the business;

– Challenged the appropriateness of the Group’s assessment of the potential impact of climate change and the impact of these on the financial statements, including in the area of intangible assets as described in section 6 to this report; and

– Used our own assessment of the impact of climate change to challenge the Group’s assessment of going concern, including considering the potential impact on future performance and availability of financing.

As part of our audit procedures, we are required to read and consider these disclosures to consider whether they are materially inconsistent with the financial statements or knowledge obtained in the audit. We did not identify any material inconsistencies as a result of these procedures.

## 4. Our application of materiality

We define materiality as the magnitude of misstatement in the financial statements that makes it probable that the economic decisions of a reasonably knowledgeable person would be changed or influenced. We use materiality both in planning the scope of our audit work and in evaluating the results of our work.



## Independent Auditor’s report continued

## Report on the audit of the financial statements continued

Based on our professional judgement, we determined materiality for the financial statements as a whole as follows:

<table><tr><td></td><td>Group financial statements</td><td>Parent company financial statements</td></tr><tr><td>Materiality</td><td>£210 million (2021: £275 million)</td><td>£52.5 million (2021: £68 million)</td></tr><tr><td>Basis for determining materiality</td><td>In determining our benchmark for materiality, we considered the metrics used by investors and other readers of the financial statements. In particular, we considered: Statutory profit before tax, Adjusted profit before tax, Revenue and Net cash flows from operations. Using professional judgement, we have determined materiality to be £210 million. Materiality reduced compared to the prior year predominantly due to the lower benchmarks resulting from the Consumer Healthcare demerger. We have removed the impact of the Gilead Settlement of £924 million received in Q1 2022 in determining our profit before tax benchmark as this is a nonrecurring item which it is not reflective of the underlying trade and due to its size would distort materiality. The below benchmarks are from continuing operations only as these were considered most relevant to the users of the financial statements.</td><td>Materiality was determined using the total assets benchmark capped at 25% of Group materiality. Our materiality represents 0.1% of total assets.</td></tr><tr><td>Statutory profit before tax</td><td>%</td><td>3.7%</td></tr><tr><td>Adjusted profit before tax*</td><td>2.9%</td><td></td></tr><tr><td>Revenue</td><td>0.7%</td><td></td></tr><tr><td>Net cash inflow from operating activities</td><td>3.2%</td><td></td></tr><tr><td colspan="3">* A reconciliation between the Statutory profit before tax and Adjusted profit before tax is detailed in the Adjusting Items section of the strategic report.</td></tr><tr><td>Rationale for the benchmark applied</td><td>Given the importance of the above metrics used by investors and other readers of the financial statements, we concluded ‘Statutory profit before tax’ to be the primary benchmark. The adjusted profit before tax, Revenue and Net cash inflow from operating activities, have been used as supporting benchmarks. The component materiality allocated to the in-scope components ranged between £40 million and £125 million. The range of materiality allocated across components (not including the parent company) in the audit of the prior year’s Group financial statements was between £83 million and £193 million.</td><td>The Parent company holds the Group’s investments and is not in itself profit-oriented. The strength of the balance sheet is the key measure of financial health that is important to shareholders since the primary concern for the Parent company is the payment of dividends. Using a benchmark of total assets is therefore the appropriate metric.</td></tr></table>

We set performance materiality at a level lower than materiality to reduce the probability that, in aggregate, uncorrected and undetected misstatements exceed the materiality for the financial statements as a whole. Group and Parent company performance materiality was set at 70% of Group and Parent materiality respectively for the 2022 audit (2021: 70%). In determining performance materiality, we considered factors including:

– Our risk assessment, including our assessment of the Group’s overall control environment and that we consider it appropriate to rely on controls over a number of business processes; and

– Our past experience of the audit, which has indicated a low number of corrected and uncorrected misstatements identified in prior periods.

We agreed with the Audit & Risk Committee that we would report to the Committee all audit differences in excess of £10 million (2021: £10 million) as well as any differences below this threshold, which in our view, warranted reporting on qualitative grounds. We also report to the Audit & Risk Committee on disclosure matters that we identified when assessing the overall presentation of the financial statements.

## 5. Conclusions relating to going concern

In auditing the financial statements, we have concluded that the directors' use of the going concern basis of accounting in the preparation of the financial statements is appropriate.

Our evaluation of the directors’ assessment of the Group’s and Parent company’s ability to continue to adopt the going concern basis of accounting included:

– Enquiries of the Group directors and management regarding the assumptions used in the going concern models, including the potential impact of climate change;

– Evaluating the Group’s existing access to sources of financing, including undrawn committed bank facilities, including the impact of changes in interest rates on profitability;

– Reading analyst reports, industry data and other external information to determine if it provided corroborative or contradictory evidence in relation to assumptions used;

– Comparing forecasted sales to recent historical financial information;

– Testing the underlying data generated to prepare the forecast scenarios and determined whether there was adequate support for the assumptions underlying the forecast; and

– Evaluating the Group’s disclosures on going concern against the requirements of IAS 1.

Based on the work we have performed, we have not identified any material uncertainties relating to events or conditions that, individually or collectively, may cast significant doubt on the Group’s and Parent company’s ability to continue as a going concern for a period of at least twelve months from when the financial statements are authorised for issue.



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In relation to the reporting on how the Group has applied the UK Corporate Governance Code, we have nothing material to add or draw attention to in relation to the Directors' statement in the financial statements about whether the Directors considered it appropriate to adopt the going concern basis of accounting. Our responsibilities and the responsibilities of the Directors with respect to going concern are described in the relevant sections of this report accounting.

## 6. Key audit matters

Key audit matters are those matters that, in our professional judgement, were of most significance in our audit of the financial statements of the current period and include the most significant assessed risks of material misstatement (whether or not due to fraud) that we identified. These matters included those which had the greatest effect on the overall audit strategy, the allocation of resources in the audit and directing the efforts of the engagement team.

We have included two additional key audit matters in 2022: the consumer healthcare demerger and the valuation of the contingent liabilities and significant legal proceedings. This reflects the additional audit effort required this year in relation to these.

These matters were addressed in the context of our audit of the financial statements as a whole, and in forming our opinion on the financial statements as a whole, we do not provide a separate opinion on these matters

## Key audit matter description

## Valuation of the ViiV Healthcare Shionogi contingent consideration liability

The Group has completed a number of significant transactions which resulted in the recognition of material contingent consideration liabilities, which are a key source of estimation uncertainty. The most significant of these liabilities was the ViiV Healthcare Shionogi Contingent Consideration Liability (ViiV CCL).

The Group completed the acquisition of the remaining 50% interest in the Shionogi-ViiV Healthcare joint venture in 2012. Upon completion, the Group recognised a contingent consideration liability for the fair value of the expected future payments to be made to Shionogi. As at 31 December 2022 the liability was valued at £5,890 million.

We identified the ViiV CCL as a key audit matter because of the significant estimates and assumptions relating to the sales forecasts used in valuing the ViiV CCL and the sensitivity of the valuation to these inputs. The most significant of these relate to sales forecasts in the United States (US) on certain products in the treatment portfolio. Such forecasts are based on an assessment of the expected launch dates, the ability to shift market practice and a prescriber behaviour towards long-acting injectable treatments and 2-drug regimens, the impact of healthcare reform and subsequent sales volumes and pricing. There is incremental challenge in forecasting sales associated with recently launched products due to the lack of historical actual data. The forecasts also required significant audit effort to perform appropriate audit procedures to challenge and evaluate the reasonableness of those forecasts.

Contingent consideration liabilities, including the ViiV CCL, are disclosed as a key source of estimation uncertainty in Note 3 of the Group financial statements with further disclosures provided in Notes 29, 33 and 44. The matter is also discussed in the Audit & Risk Committee report within the Corporate Governance section of the Annual Report.

## How the scope of our audit responded to the key audit matter

## Audit procedures performed

We performed the following audit procedures, amongst others, related to the sales forecasts:

– Obtained the Group’s assessment of the key inputs and assumptions used in the forecasts and challenged the reasonableness of these, including through enquiries of key individuals from the senior leadership team, commercial strategy team and key personnel involved in the budgeting and forecasting process, and inspection of supporting evidence;

– Challenged the US volume assumptions made by the Group to estimate sales forecasts. This involved benchmarking forecast market share data against external data, such as total prescription volumes and new patient prescription volumes, in order to assess for any sources of contradictory evidence;

– Challenged the reasonableness of US pricing assumptions by the Group, by comparing the forecasted Returns and Rebates rate by product against the current rate, and assessing the forecasted Returns and Rebates against comparable products considering expected changes in payer policy and healthcare reform implications;

– Considered the results of clinical studies undertaken in the year by the Group and key competitors in order to assess whether these are corroborative or contradictory to assumptions used in the product portfolio sales forecasts in the US;

– Benchmarked the Group’s sales forecasts against those included in reports from nine analysts and considered sales forecasts on both a total ViiV basis and an individual product basis, assessing against identified contradictory data; and

– Tested the controls over the key inputs and assumptions used in the valuation of the contingent consideration liability, including review controls over the sales forecasts of the treatment product portfolio used to value the ViiV CCL.

## Key observations communicated to the Audit & Risk Committee

The sales forecasts used in the valuation are reasonable and in line with relevant supporting information. We are satisfied that the sales forecasts appropriately reflect trends in the overall HIV treatment and prevention markets including the impacts of competition, healthcare reform and a predicted shifts towards long-acting injectable products.

The approach to valuing the ViiV CCL was consistent with prior periods and overall we are satisfied that the valuation liability is reasonable and consistent with IFRS.



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## Key audit matter description

Valuation of US Returns and Rebates (RAR) accruals
In the US the Group sells to customers under various commercial and government mandated contracts and reimbursement arrangements that include rebates, chargebacks and a right of return for certain pharmaceutical products. As such, revenue recognition reflects gross-to-net sales adjustments. These adjustments are known as the Returns and Rebates (RAR) accruals and are a source of significant estimation uncertainty which could have a material impact on reported revenue.

In US Commercial Operations in 2022 £15,272 million of RAR deductions were made to gross revenue of £29,814 million, resulting in net revenue of £14,542 million. The balance sheet accrual at 31 December 2022 for US Commercial Operations amounted to £5,855 million.

The four most significant payer channels (also referred to as buying groups) to which the RAR accrual relates are managed healthcare organisations, Medicaid, Ryan White and Medicare Part D.

The two main causes of significant estimation uncertainty are:

– The utilisation rate, which is the portion of total sales that will be made into each payer channel, estimated by the Group in recording the accruals. The utilisation assumption is the most challenging of the key assumptions used to derive the accrual given that it is influenced by market demand and other factors outside the control of the Group; and

– The time lag between the point of sale and the point at which exact rebate amounts are known to the Group upon receipt of a claim. Those payer channels with the longest time lag result in a greater accrued period, and therefore, a greater level of estimation uncertainty in estimating the period end accrual.

The level of estimation uncertainty is also impacted by significant shifts in channel mix driven by changes in the competitive landscape, including competitor and generic product launches and other macroeconomic factors. As such, we focus on the utilisation assumptions for those products where we deem the level of estimation uncertainty to be the most significant.

Furthermore, auditing standards presume that a significant fraud risk exists in revenue recognition. In line with this presumption, we also focus on the period-end adjustments made to the RAR accruals. These adjustments reflected updates made to the initial assumptions included within the forecasted RAR rates and, in our view, present the greatest opportunity for fraud in revenue recognition (notwithstanding the existence of internal controls).

US Commercial Operations returns and rebates are disclosed as a key source of estimation uncertainty in Note 3 of the Group financial statements with further disclosures provided in Note 29. The matter is also discussed in the Audit & Risk Committee report within the Corporate Governance section of the Annual Report.
How the scope of our audit responded to the key audit matter

## Audit procedures performed

We performed the following audit procedures, amongst others, related to estimates in the RAR accruals:

– Challenged assumptions for a selection of utilisation rates, focusing on certain products where we concluded the accrual is most sensitive to these assumptions. Our challenge included comparison to historical utilisation rates, consideration of historical accuracy and drivers of market changes such as the impact of competition and macroeconomic trends;

– Supplemented this with substantive analytical procedures by developing an independent expectation of the accrual balance for each of the key segments, based on historical claims received adjusted to reflect market changes in the period including an assessment of the time lag between the initial point of sale and the claim receipt. We then compared this independent expectation to those recorded to evaluate the appropriateness of the year ending accrual position;

– Considered the historical accuracy of estimates and evaluated whether forecast assumptions had been appropriately updated in a selection of cases where the actual rebate claims differed to the amount accrued;

– Evaluated the appropriateness of, and completeness of, period-end adjustments to the liability made as part of the ongoing review of the estimated accrual; and

– Tested the key controls over the estimation of RAR accruals including the controls associated with the forecasting of utilisation rates process and the month-end accrual review controls.

## Key observations communicated to the Audit & Risk Committee

We are satisfied that the estimated liability of the RAR accruals at the year-end is appropriate. We observed a level of prudence in the estimate when assessing against our own independent expectations, in accordance with the requirements of IFRS 15 Revenue from contracts with customers to limit the risk of a significant reversal of revenue.



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## Key audit matter description

## Valuation of other intangible assets

As at 31 December 2022, the Group held £13,663 million of other intangible assets (including licenses, patents, trademarks, and trade names, but excluding goodwill and computer software). This includes £2,964 million of intangible assets acquired as part of business combinations with Sierra Oncology Inc and Affinivax Inc during the year. During 2022, impairment charges of £330 million were recorded.

An individual intangible asset, or an intangible asset which forms part of a cash-generating unit, is impaired when its carrying amount exceeds its recoverable amount. The recoverable amount of these other intangible assets relies on certain assumptions and estimates of future trading performance which create estimation uncertainty.

Future trading performance of intangible assets includes key assumptions such as sales pricing, volume, growth rates and probability of technical and regulatory success of ongoing clinical trials. This includes assumptions on timing of cash flows determined by anticipated launch year, peak year sales, subsequent sales erosion due to generic product competition and profit margin levels. In addition, due to the impact of uncertainty driven by ongoing global macroeconomic volatility, the valuation of intangible assets will also be affected by discount rate assumptions made by the Group.

We identified the valuation of other intangible assets as a key audit matter due to the inherent judgements involved in estimating future cash flows. Auditing such assumptions and estimates required extensive audit effort to challenge and evaluate the reasonableness of forecasts and judgements.

The disclosures relating to other intangible assets, including those acquired as part of business combinations, are included in Note 20 and 41 of the Group financial statements. The matter is also discussed in the Audit & Risk Committee report within the Corporate Governance section of the Annual Report.

## How the scope of our audit responded to the key audit matter

## Audit procedures performed

We performed the following audit procedures, amongst others, related to the future sales pricing, volume, growth rates and probability of technical and regulatory success, profit margin levels, and discount rates used in the assessment in the valuation of other intangible assets:

– Inquired with the key individuals from the corporate development team, commercial forecasting leads, and key personnel involved in the assets research and development process to discuss and evaluate the Group’s evidence to support the future pricing, volume, sales growth rates and probability of regulatory and technical success;

– Evaluated the key inputs and assumptions applied in estimating sales and profit margin forecasts, including benchmarking of forecasts against external market data. This included independent market research of therapeutic area price points, price growth rates, and anticipated competitor market landscape, currently and at the time of forecast regulatory approval, plus assessment of any sources of contradictory evidence;

– Inspected independent research and literature to consider corroborative and contradictory evidence to assess assumptions on probability of technical and regulatory success;

– Compared the forecast sales and profit margin levels to the Plan data (asset by asset internal forecasts) approved by the GSK Leadership Team and the Board of Directors, where the in-development intangible asset is forecast to launch within the next 3-year period;

– Assessed the historical accuracy of sales forecasts by performing retrospective reviews across marketed assets within the business;

– Considered whether events or transactions that occurred after the balance sheet date but before the reporting date affect the conclusions reached on the carrying values of the assets and associated disclosures;

– Engaged Internal Fair Valuation Specialists (IFVS) to assess the reasonableness of discount rates and valuation methodology applied; and

– Tested review controls over the key inputs and assumptions used in the valuation of other intangible assets. The controls encompass review of the valuation models, which contain a number of assumptions such as the probability of technical and regulatory success, launch dates plus other revenue and cost assumptions number of assumptions such as the revenue growth rates and profit margins.

## Key observations communicated to the Audit & Risk Committee

For those intangible assets which were acquired during the period as part of the Sierra Oncology Inc and Affinivax Inc business acquisition, although we identified some control deficiencies we concluded that the complex assumptions underpinning the fair value of intangible assets reflected in the purchase price allocations were reasonable and in accordance with IFRS.

For those intangible assets in-development and subject to impairment reviews we concluded that the judgements made by the directors were reasonable and in accordance with IFRS. We are satisfied that the controls over intangible assets are designed and operating effectively or control deficiencies identified were mitigated by compensating controls.



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## Key audit matter description

Valuation of uncertain tax positions, including transfer pricing
The Group operates in numerous jurisdictions and there are open tax and transfer pricing matters and exposures with UK, US and overseas tax authorities that give rise to uncertain tax positions. There is a wide range of possible outcomes for provisions and contingencies. Certain judgements in respect of estimates of tax exposures and contingencies are required in order to assess the adequacy of tax provisions, which are sometimes complex as a result of the considerations required over multiple tax laws and regulations.

At 31 December 2022, the Group has recorded provisions of £551 million in respect of uncertain tax positions.

Valuation of uncertain tax positions is disclosed as a key source of estimation uncertainty in Note 3 of the Group financial statements with further disclosures included in Note 14. The matter is also discussed in the Audit & Risk Committee report within the Corporate Governance section of the Annual Report.
How the scope of our audit responded to the key audit matter

## Audit procedures performed

With the support of tax specialists, we assessed the appropriateness of the uncertain tax provisions by performing the following audit procedures amongst others:

– Assessed and challenged provisions for uncertain tax positions through the evaluation of possible outcomes. Our procedures were focused on those jurisdictions where the Group has the greatest potential exposure and where the highest level of judgement is required;

– Assessed the assumptions and judgements that are required to determine the range of possible outcomes for recognition and measurement of uncertain tax positions in compliance with the requirements of IFRIC 23;

– Involved our transfer pricing specialists to evaluate the transfer pricing methodology of the Group and associated approach to provision recognition and measurement;

– Considered evidence such as the actual results from the recent tax authority audits and enquiries, third-party tax advice obtained by the Group and our tax specialists' own knowledge of market practice in relevant jurisdictions; and

– Tested key controls over preparation, review and reporting of judgmental tax balances and transactions, which include provisions for uncertain tax provisions.

## Key observations communicated to the Audit & Risk Committee

We are satisfied that the estimates in relation to uncertain tax positions and the related disclosures are in accordance with IFRS. From our work we concluded that a consistent approach has been applied to estimating uncertain tax provisions which, whilst continuing to be prudent as required by IFRIC 23, are appropriate and supportable.



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## Key audit matter description

## Consumer Healthcare Demerger

As set out in Note 41, on 18 July 2022, GSK plc separated its Consumer Healthcare business from the GSK Group to form Haleon, an independent listed company. The separation was effected by way of a demerger of 80.1% of GSK's 68% holding in the Consumer Healthcare business to GSK shareholders. GSK retained 13.5% of Haleon (7.5% are held by Scottish Limited Partnership structures (SLPs)) which are recognised as an equity investment as set out in Note 22. The Group derecognised net assets and liabilities of £12.9 billion and recognised a gain on demerger of £10.1 billion.

The Consumer Healthcare trading results to the demerger date have been presented as a part of discontinued operations and the comparative results have been restated on a consistent basis. At the demerger date the assets and liabilities of the Consumer business have been derecognised from the balance sheet, with the difference between the value of the net assets and the fair value of the demerged business recognised in the consolidated income statement as a gain on demerger. The cumulative exchange differences arising on translation of those Consumer Healthcare foreign currency net assets, previously included in other comprehensive income, have also been recognised in the consolidated income statement.

We identified the demerger of Consumer Healthcare as a key audit matter because of the significant estimates related to calculating the gain on demerger and remeasuring the retained stake upon demerger, assessing the perimeters of the demerged business, validating the cumulative exchange differences arising on translation of the foreign currency net assets of the divested businesses, evaluating the Group's tax treatment of the demerger and assessing the impact on relevant IT systems prior to the demerger. This required a high degree of auditor judgment and an increased extent of effort, including the need to involve our technical accounting, tax, and IT specialists, when performing audit procedures.

The matter is also discussed in the Audit & Risk Committee report within the Corporate Governance section of the Annual Report.
How the scope of our audit responded to the key audit matter

## Audit procedures performed

We performed the following audit procedures, amongst others, related to the Consumer Healthcare demerger:

– Consulted with technical accounting specialists to evaluate the entity’s accounting conclusions in respect of the relevant accounting standards for the demerger steps including:

– the presentation of Consumer Healthcare results as a part of discontinued operations;

– the calculation of the gain on demerger; and

– the retained stake upon demerger.

– Recalculated the gain on demerger and the fair value of the Consumer Healthcare business at the demerger date;

– Tested the accuracy and completeness of the perimeters of the demerged business by inspecting legal agreements and recalculating the cumulative exchange differences arising on translation of the foreign currency net assets;

– Engaged tax specialists to assess the impact of the demerger on the Group tax balances;

– Engaged IT specialists to assess the impact on the relevant IT systems prior to the demerger of Consumer Healthcare; and

– Tested key controls over IT and the reporting of the Consumer Healthcare Demerger including the review and approval of the accounting considerations, accuracy and completeness of transactions to the demerger date, the cumulative exchange reserve and the adjustments required in relation to the classification between continued and discontinued operations.

## Key observations communicated to the Audit & Risk Committee

We are satisfied that the Group’s accounting conclusions, calculation of the gain from demerger and presentation of discontinued operations in respect of the demerger of the Consumer Healthcare business are appropriate and in accordance with IFRS.



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## Key audit matter description

## IT systems that impact financial reporting

The IT systems within the Group form a critical component of the Group’s financial reporting activities and impact all account balances.

We identified the IT systems that impact financial reporting as a key audit matter because of the:

– Pervasive reliance on complex technology that is integral to the operation of key business processes and financial reporting;

– Reliance on technology which continues to increase in line with the business strategy, such as the increase in the use of automation across the Group;

– Importance of the IT controls in maintaining an effective control environment. A key interdependency exists between the ability to rely on IT controls and the ability to rely on financial data, system configured automated controls and system reports;

– Continued remediation of IT controls supporting the application systems relevant to the Group’s financial reporting activities; and

– Separation activities undertaken across the Technology environment as part of the GSK Consumer Healthcare separation programme.

IT systems which impact financial reporting are discussed in the Audit & Risk Committee report within the Corporate Governance section of the Annual Report.
How the scope of our audit responded to the key audit matter

## Audit procedures performed

Our IT audit scope is driven by the level of reliance placed on technology to obtain sufficient audit evidence within a business process. The technology deemed relevant to the audit is based on the financial data, system configured automated controls and/or key financial reports that reside within it. We used IT specialists to support our evaluation of the risks associated with technology and with the testing of the design and operation of IT controls.

Testing over the technology deemed relevant to the audit included the following areas:

– General IT controls, including user access and change management controls;

– Key financial reports and system configured automated controls;

– Controls to provide assurance over the completeness and accuracy of relevant data migrations, including GSK Consumer Healthcare separation activities; and

– Testing of remediation of previously identified deficiencies.

Our risk assessment procedures included an assessment of the impact of all unmediated IT control deficiencies to determine the impact on our audit plan. Where relevant, the audit plan was adjusted to include the testing of additional manual business process controls to mitigate the unaddressed IT risk.

## Key observations communicated to the Audit & Risk Committee

We are satisfied that IT controls impacting the Group’s financial reporting activities are designed and operating effectively or control deficiencies identified were remediated by year end or mitigated by compensating controls.

Significant progress was made in remediating control deficiencies relating to user access and change management. The Group has many layers of business process controls to mitigate the risk associated with the remaining IT control deficiencies.



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Key audit matter description

Valuation of the contingent liabilities and significant legal proceedings

The Group operates in an environment where it is subject to significant legal and administrative proceedings, including product liability, intellectual property, tax, anti-trust, consumer fraud and governmental regulations.

The Group is currently exposed to a number of regulatory and litigation matters. In the current year, the Group classified the Zantac litigation as a significant legal matter due to the increase in cases. The Group’s provision for these matters is £218 million at 31 December 2022. Other matters are disclosed as contingent liabilities where the criteria for recognising a provision under IAS 37 Provisions, Contingent Liabilities and Contingent Assets are not met.

We identified contingent liabilities and significant legal proceedings as a key audit matter because of the significant judgement required by the Group in determining whether, under IAS 37, in particular in relation to the Zantac matter, as to:

– Whether the outcome will result in a probable outflow, particularly where the outcome of litigation is uncertain and subject to additional court proceedings;

– The determination of a reliable estimate can be made of the amounts of the obligation; and

– The nature and extent of any contingent liabilities and underlying significant estimation uncertainties disclosed.

Contingent liabilities and Significant legal proceedings are disclosed in Notes 35 and 47, respectively. The key audit matter is discussed within the Corporate Governance section of the Annual Report.

## Audit procedures performed

We performed the following audit procedures:

– Tested the Group’s controls over the completeness of provisions, the robustness of the provision against the requirements of IAS 37, the appropriateness of judgements used to determine a ‘best estimate’ and completeness and accuracy of data used in the process;

– Evaluated the assessment of the provisions, associated probabilities, and potential outcomes in accordance with IAS 37;

– Evaluated the methodology, data and significant judgements and assumptions used in the valuation of the provisions are appropriate in the context of the applicable financial reporting framework;

– Inquired with and inspected correspondence from the Group’s internal and external counsel to assess the litigation matter and evaluate the Group’s significant judgements and assumptions;

– Where no provision was made, we critically evaluated the Group’s conclusion supportive and contradictory evidence and the requirements of IAS 37, particularly with respect to the Zantac matter;

– In respect of the Zantac matter, we inspected the evidence presented in relevant scientific studies and the outcomes of other product liability litigation in the same jurisdictions alongside the entity’s assessment of possible outcomes of each ongoing and future trials; and

– Evaluated whether the disclosures made in the financial statements appropriately reflect the facts and critical accounting judgements.

Key observations communicated to the Audit & Risk Committee

We are satisfied that the estimation of the provisions and contingent liability disclosures are consistent with the requirements of IAS 37.



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## 7. Other information

The other information comprises the information included in the Annual Report, other than the financial statements and our auditor's report thereon. The Directors are responsible for the other information contained within the Annual Report. Our opinion on the financial statements does not cover the other information and, except to the extent otherwise explicitly stated in our report, we do not express any form of assurance conclusion thereon.

Our responsibility is to read the other information and, in doing so, consider whether the other information is materially inconsistent with the financial statements or our knowledge obtained in course of the audit or otherwise appears to be materially misstated.

If we identify such material inconsistencies or apparent material misstatements, we are required to determine whether this gives rise to a material misstatement in the financial statements themselves. If, based on the work we have performed, we conclude that there is a material misstatement of this other information, we are required to report that fact.

We summarise below our work in relation to areas of the other information including those areas upon which we are specifically required to report:

Matters we are specifically required to report

<table><tr><td>Our responsibility</td><td>Our reporting</td></tr><tr><td>Principal risks and viability statementReview the confirmation and description in the light of the knowledge gathered during the audit, such as through considering the directors&#x27; processes to support the statements made, challenging key judgements and estimates, consideration of historical forecasting accuracy and evaluating macro-economic assumptions.</td><td>As set out in the &quot;Corporate governance statement&quot; section, we have nothing material to report, add or draw attention to in respect of these matters.</td></tr><tr><td>Consider if the statements are aligned with the relevant provisions of the Code.</td><td></td></tr><tr><td>Directors&#x27; Remuneration reportReport whether the part of the Directors&#x27; Remuneration report to be audited is properly prepared and the disclosures specified by the Companies Act have been made.</td><td>As set out in the &quot;Opinions on other matters prescribed by the Companies Act 2006&quot; section, in our opinion, the part of the directors&#x27; remuneration report to be audited has been prepared in accordance with the Companies Act 2006.</td></tr><tr><td>Strategic report and directors&#x27; reportReport whether they are consistent with the audited financial statements and are prepared in accordance with applicable legal requirements.</td><td>As set out in the &quot;Opinions on other matters prescribed by the Companies Act 2006&quot; section, in our opinion, based on the work undertaken in the course of the audit, the information in these reports is consistent with the audited financial statements and has been prepared in accordance with applicable legal requirements.</td></tr><tr><td>Report if we have identified any material misstatements in either report in the light of the knowledge and understanding of the Group and of the Parent company and their environment obtained in the course of the audit.</td><td>As referenced on page 62, we have provided limited assurance in accordance with International Standards for Assurance Engagements 3000 (ISAE 3000) and Assurance Engagements on Greenhouse Gas Emissions 3410 (ISAE 3410) issued by the International Auditing and Assurance Standards Board (IAASB) over selected metrics.</td></tr></table>



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Other reporting on other information

<table><tr><td>Our responsibility</td><td>Our reporting</td></tr><tr><td>Alternative performance measures (APMs)APMs are measures that are not defined by generally accepted accounting practice (GAAP) and therefore are not typically included in the financial statement part of the Annual Report. The Group uses APMs, such as adjusted profit, free cash flow and constant currency growth rates in its reporting of financial performance.We have reviewed and assessed the calculation and reporting of these metrics to assess consistency with the Group’s published definitions and policies for these items.We have also considered and assessed whether the use of APMs in the Group’s reporting results is consistent with the guidelines produced by regulators such as the European Securities and Markets Authority (ESMA) guidelines on the use of APMs and the FRC Alternative Performance Measures Thematic Review published in October 2021.We also considered whether there was an appropriate balance between the use of statutory metrics and APMs, in addition to whether clear definitions and reconciliation for APMs used in financial reporting have been provided.</td><td>In our opinion:- the use, calculation and disclosure of APMs is consistent with the Group’s published definitions and policies;- the use of APMs in the Group’s reporting results is consistent with the guidelines produced by ESMA and FRC; and- there is an appropriate balance between the use of statutory metrics and APMs, together with clear definitions and reconciliation for APMs used in financial reporting.</td></tr></table>

## 8. Responsibilities of directors

As explained more fully in the directors’ responsibilities statement, the directors are responsible for the preparation of the financial statements and for being satisfied that they give a true and fair view, and for such internal control as the directors determine is necessary to enable the preparation of financial statements that are free from material misstatement, whether due to fraud or error.

In preparing the financial statements, the directors are responsible for assessing the Group’s and the Parent company’s ability to continue as a going concern, disclosing as applicable, matters related to going concern and using the going concern basis of accounting unless the directors either intend to liquidate the Group or the Parent company or to cease operations, or have no realistic alternative but to do so.

## 9. Auditor’s responsibilities for the audit of the financial statements

Our objectives are to obtain reasonable assurance about whether the financial statements as a whole are free from material misstatement, whether due to fraud or error, and to issue an auditor’s report that includes our opinion. Reasonable assurance is a high level of assurance but is not a guarantee that an audit conducted in accordance with ISAs (UK) will always detect a material misstatement when it exists. Misstatements can arise from fraud or error and are considered material if, individually or in the aggregate, they could reasonably be expected to influence the economic decisions of users taken on the basis of these financial statements.

A further description of our responsibilities for the audit of the financial statements is located on the FRC’s website at: www.frc.org.uk/auditorsresponsibilities. This description forms part of our auditor’s report.



## Independent Auditor’s report continued

Report on the audit of the financial statements continued

## 10. Extent to which the audit was considered

capable of detecting irregularities, including fraud
Irregularities, including fraud, are instances of non-compliance with laws and regulations. We design procedures in line with our responsibilities, outlined above, to detect material misstatements in respect of irregularities, including fraud. The extent to which our procedures are capable of detecting irregularities, including fraud is detailed below.

## Identifying and assessing potential risks related to irregularities

In identifying and assessing the risks of material misstatement in respect of irregularities, including fraud and non-compliance with laws and regulations, we considered the following:

– the nature of the industry and sector, control environment and business performance including the design of the Group’s remuneration policies, key drivers for directors’ remuneration, bonus levels and performance targets;

– results of our enquiries of the senior leadership team, internal audit and the Audit & Risk Committee, including obtaining and reviewing supporting documentation, concerning the Group’s policies and procedures relating to:

– identifying, evaluating and complying with laws and regulations and whether they were aware of any instances of non-compliance;

– detecting and responding to the risks of fraud and whether they have knowledge of any actual, suspected or alleged fraud; and

– the internal controls established to mitigate risks related to fraud or non-compliance with laws and regulations; and

– the matters discussed among the engagement team including significant component audit teams and involving relevant internal specialists, including tax, valuations, pensions, IT and industry specialists regarding how and where fraud might occur in the financial statements and any potential indicators of fraud.

We obtained an understanding of the legal and regulatory frameworks that the Group operates in, focusing on provisions of those laws and regulations that had a direct effect on the determination of material amounts and disclosures in the financial statements. The key laws and regulations we considered in this context included the provisions of the UK Companies Act, pensions legislation and tax legislation. We have also considered key laws and regulations that had a fundamental effect on the operations of the Group, including the Good Clinical Practice, the FDA regulations, General Data Protection requirements, Anti-bribery and corruption policy and the Foreign Corrupt Practices Act.

## Audit response to risks identified

As a result of performing the above, we identified the Valuation of US Returns and Rebates accruals as a key audit matter related to the potential risk of fraud. The key audit matters section of our report explains the matter in more detail and also describes the specific procedures in response to that key audit matter. In common with all audits under ISAs (UK), we are also required to perform specific procedures to respond to the risk of management override.

In addition to the above, our procedures to respond to risks identified included the following:

– reviewing the financial statement disclosures and testing to supporting documentation to assess compliance with provisions of relevant laws and regulations described as having a direct effect on the financial statements;

– enquiring of the senior leadership team, the Audit & Risk Committee and in-house and external legal counsel concerning actual and potential litigation and claims;

– performing analytical procedures to identify any unusual or unexpected relationships that may indicate risks of material misstatement due to fraud;

– reading minutes of meetings of those charged with governance, reviewing internal audit reports and correspondence with regulators; and

– in addressing the risk of fraud through management override of controls, testing the appropriateness of journal entries and other adjustments; assessing whether the judgements made in making accounting estimates are indicative of a potential bias; and evaluating the business rationale of any significant transactions that are unusual or outside the normal course of business.

We also communicated relevant identified laws and regulations and potential fraud risks to all engagement team members and significant component audit teams and remained alert to any indications of fraud or non-compliance with laws and regulations throughout the audit.

## Report on other legal and regulatory requirements

## 11. Opinions on other matters prescribed by the Companies Act 2006

In our opinion, the part of the Directors' Remuneration report to be audited has been properly prepared in accordance with the Companies Act 2006.

In our opinion, based on the work undertaken in the course of the audit:

– the information given in the strategic report and the directors' report for the financial year for which the financial statements are prepared is consistent with the financial statements; and

– the strategic report and the directors' report have been prepared in accordance with applicable legal requirements.



## Independent Auditor’s report continued

## Report on the audit of the financial statements continued

In the light of the knowledge and understanding of the Group and of the Parent company and their environment obtained in the course of the audit, we have not identified any material misstatements in the strategic report or the directors' report.

## 12. Corporate governance statement

The Listing Rules require us to review the directors' statement in relation to going concern, longer-term viability and that part of the corporate governance statement relating to the Group's compliance with the provisions of the UK Corporate Governance Code specified for our review.

Based on the work undertaken as part of our audit, we have concluded that each of the following elements of the Corporate Governance Statement is materially consistent with the financial statements and our knowledge obtained during the audit:

– the directors’ statement with regards to the appropriateness of adopting the going concern basis of accounting and any material uncertainties identified set out on page 167;

– the directors’ explanation as to its assessment of the Group’s prospects, the period this assessment covers and why the period is appropriate is set out on page 64;

– the directors’ statement on fair, balanced and understandable Annual Report set out on page 129;

– the board’s confirmation that it has carried out a robust assessment of the emerging and principal risks set out on pages 51 to 54;

– the section of the Annual Report that describes the review of effectiveness of risk management and internal control systems set out on pages 125 to 126; and

– the section describing the work of the audit and risk committee set out on page 124 to 129.

## 13. Matters on which we are required to report by exception

Adequacy of explanations received and accounting records Under the Companies Act 2006 we are required to report to you if, in our opinion:

– we have not received all the information and explanations we require for our audit; or

– adequate accounting records have not been kept by the Parent company, or returns adequate for our audit have not been received from branches not visited by us; or

– the Parent company financial statements are not in agreement with the accounting records and returns.

We have nothing to report in respect of these matters.

## Directors' remuneration

Under the Companies Act 2006 we are also required to report if in our opinion certain disclosures of directors' remuneration have not been made or the part of the directors' remuneration report to be audited is not in agreement with the accounting records and returns.

We have nothing to report in respect of these matters.

## 14. Other matters which we are required to address

## Auditor tenure

Following the recommendation of the Audit & Risk Committee, with effect from 1 January 2018 we were appointed by the Board of Directors to audit the financial statements for the year ended 31 December 2018 and subsequent financial periods. The period of total uninterrupted engagement of the firm is five years.

Consistency of the audit report with the additional report to the Audit & Risk Committee

Our audit opinion is consistent with the additional report to the Audit & Risk Committee we are required to provide in accordance with ISAs (UK).

## 15. Use of our report

This report is made solely to the Parent company’s members, as a body, in accordance with Chapter 3 of Part 16 of the Companies Act 2006. Our audit work has been undertaken so that we might state to the Parent company’s members those matters we are required to state to them in an auditor’s report and for no other purpose. To the fullest extent permitted by law, we do not accept or assume responsibility to anyone other than the Parent company and the Parent company’s members as a body, for our audit work, for this report, or for the opinions we have formed.

In due course, as required by the Financial Conduct Authority (FCA) Disclosure Guidance and Transparency Rule (DTR) 4.1.14R, these financial statements will form part of the European Single Electronic Format (ESEF)-prepared Annual Financial Report filed on the National Storage Mechanism of the UK FCA in accordance with the ESEF Regulatory Technical Standard (ESEF RTS). This auditor’s report provides no assurance over whether the annual financial report has been prepared using the single electronic format specified in the ESEF RTS.

The Parent company has passed a resolution in accordance with section 506 of the Companies Act 2006 that the senior statutory auditor’s name should not be stated.

Deloitte LLP
Statutory Auditor
London, United Kingdom
9 March 2023



## Consolidated income statement
for the year ended 31 December 2022

<table><tr><td></td><td>Notes</td><td>2022
£m</td><td>2021(1)
£m</td><td>2020(1)
£m</td></tr><tr><td>Turnover</td><td>6</td><td>29,324</td><td>24,696</td><td>24,354</td></tr><tr><td>Cost of sales</td><td></td><td>(9,554)</td><td>(8,163)</td><td>(7,929)</td></tr><tr><td>Gross profit</td><td></td><td>19,770</td><td>16,533</td><td>16,425</td></tr><tr><td>Selling, general and administration</td><td></td><td>(8,372)</td><td>(7,070)</td><td>(7,437)</td></tr><tr><td>Research and development</td><td></td><td>(5,488)</td><td>(5,019)</td><td>(4,793)</td></tr><tr><td>Royalty income</td><td></td><td>758</td><td>417</td><td>321</td></tr><tr><td>Other operating (expense)/income</td><td>7</td><td>(235)</td><td>(504)</td><td>1,463</td></tr><tr><td>Operating profit</td><td>8</td><td>6,433</td><td>4,357</td><td>5,979</td></tr><tr><td>Finance income</td><td>11</td><td>76</td><td>14</td><td>32</td></tr><tr><td>Finance expense</td><td>12</td><td>(879)</td><td>(769)</td><td>(874)</td></tr><tr><td>Loss on disposal of interest in associates</td><td>13</td><td>-</td><td>(36)</td><td>-</td></tr><tr><td>Share of after tax (loss)/profits of associates and joint ventures</td><td></td><td>(2)</td><td>33</td><td>33</td></tr><tr><td>Profit before taxation</td><td></td><td>5,628</td><td>3,599</td><td>5,170</td></tr><tr><td>Taxation</td><td>14</td><td>(707)</td><td>(83)</td><td>(67)</td></tr><tr><td>Profit after taxation from continuing operations</td><td></td><td>4,921</td><td>3,516</td><td>5,103</td></tr><tr><td>Profit after taxation from discontinued operations and other gains/(losses) from the demerger</td><td></td><td>3,049</td><td>1,580</td><td>1,285</td></tr><tr><td>Re-measurement of discontinued operations distributed to shareholders on demerger</td><td></td><td>7,651</td><td>-</td><td>-</td></tr><tr><td>Profit after taxation from discontinued operations</td><td></td><td>10,700</td><td>1,580</td><td>1,285</td></tr><tr><td>Total profit after taxation for the year</td><td></td><td>15,621</td><td>5,096</td><td>6,388</td></tr><tr><td>Profit attributable to non-controlling interests from continuing operations</td><td></td><td>460</td><td>200</td><td>230</td></tr><tr><td>Profit attributable to shareholders from continuing operations</td><td></td><td>4,461</td><td>3,316</td><td>4,873</td></tr><tr><td>Profit attributable to non-controlling interests from discontinued operations</td><td></td><td>205</td><td>511</td><td>409</td></tr><tr><td>Profit attributable to shareholders from discontinued operations</td><td></td><td>10,495</td><td>1,069</td><td>876</td></tr><tr><td></td><td></td><td>15,621</td><td>5,096</td><td>6,388</td></tr><tr><td>Total profit attributable to non-controlling interests</td><td></td><td>665</td><td>711</td><td>639</td></tr><tr><td>Total profit attributable to shareholders</td><td></td><td>14,956</td><td>4,385</td><td>5,749</td></tr><tr><td></td><td></td><td>15,621</td><td>5,096</td><td>6,388</td></tr><tr><td>Basic earnings per share (pence) from continuing operations</td><td>15</td><td>110.8p</td><td>82.9p</td><td>122.4p</td></tr><tr><td>Basic earnings per share (pence) from discontinued operations</td><td></td><td>260.6p</td><td>26.7p</td><td>22.0p</td></tr><tr><td>Total Basic earnings per share (pence)</td><td></td><td>371.4p</td><td>109.6p</td><td>144.4p</td></tr><tr><td>Diluted earnings per share (pence) from continued operations</td><td>15</td><td>109.2p</td><td>81.8p</td><td>120.9p</td></tr><tr><td>Diluted earnings per share (pence) from discontinued operations</td><td></td><td>257.0p</td><td>26.4p</td><td>21.7p</td></tr><tr><td>Total diluted earnings per share (pence)</td><td></td><td>366.2p</td><td>108.2p</td><td>142.6p</td></tr></table>

## Consolidated statement of comprehensive income for the year ended 31 December 2022

<table><tr><td></td><td>Notes</td><td>2022
£m</td><td>2021(1)
£m</td><td>2020(1)
£m</td></tr><tr><td>Total profit for the year</td><td></td><td>15,621</td><td>5,096</td><td>6,388</td></tr><tr><td>Other comprehensive income/(expense) for the year</td><td></td><td></td><td></td><td></td></tr><tr><td>Items that may be subsequently reclassified to continuing operations income statement:</td><td></td><td></td><td></td><td></td></tr><tr><td>Exchange movements on overseas net assets and net investment hedges</td><td>38</td><td>113</td><td>(339)</td><td>(416)</td></tr><tr><td>Reclassification of exchange movements on liquidation or disposal of overseas subsidiaries and associates</td><td>38</td><td>2</td><td>(25)</td><td>36</td></tr><tr><td>Fair value movements on cash flow hedges</td><td></td><td>(18)</td><td>5</td><td>(19)</td></tr><tr><td>Reclassification of cash flow hedges to income statement</td><td></td><td>14</td><td>12</td><td>54</td></tr><tr><td>Deferred tax on fair value movements on cash flow hedges</td><td></td><td>9</td><td>(8)</td><td>(18)</td></tr><tr><td></td><td></td><td>120</td><td>(355)</td><td>(363)</td></tr><tr><td>Items that will not be reclassified to continuing operations income statement:</td><td></td><td></td><td></td><td></td></tr><tr><td>Exchange movements on overseas net assets of non-controlling interests</td><td>38</td><td>(28)</td><td>(20)</td><td>(10)</td></tr><tr><td>Fair value movements on equity investments</td><td></td><td>(754)</td><td>(911)</td><td>1,346</td></tr><tr><td>Tax on fair value movements on equity investments</td><td></td><td>56</td><td>131</td><td>(220)</td></tr><tr><td>Remeasurement (losses)/gains on defined benefit plans</td><td></td><td>(786)</td><td>940</td><td>(164)</td></tr><tr><td>Tax on remeasurement losses/(gains) on defined benefit plans</td><td></td><td>211</td><td>(223)</td><td>55</td></tr><tr><td>Fair value movements on cash flow hedges</td><td></td><td>(6)</td><td>-</td><td>-</td></tr><tr><td></td><td></td><td>(1,307)</td><td>(83)</td><td>1,007</td></tr><tr><td>Other comprehensive expense for the year from continuing operations</td><td>38</td><td>(1,187)</td><td>(438)</td><td>644</td></tr><tr><td>Other comprehensive income for the year from discontinued operations</td><td></td><td>356</td><td>101</td><td>326</td></tr><tr><td>Total comprehensive income for the year</td><td></td><td>14,790</td><td>4,759</td><td>7,358</td></tr><tr><td>Total comprehensive income for the year attributable to:</td><td></td><td></td><td></td><td></td></tr><tr><td>Shareholders</td><td></td><td>14,153</td><td>4,068</td><td>6,753</td></tr><tr><td>Non-controlling interests</td><td></td><td>637</td><td>691</td><td>605</td></tr><tr><td>Total comprehensive income for the year</td><td></td><td>14,790</td><td>4,759</td><td>7,358</td></tr></table>

(1) The 2021 and 2020 comparatives have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see Note 4I) and/or the impact of Share Consolidation (see Note 37).



## Consolidated balance sheet
as at 31 December 2022

<table><tr><td></td><td>Notes</td><td>2022
£m</td><td>2021
£m</td></tr><tr><td>Non-current assets</td><td></td><td></td><td></td></tr><tr><td>Property, plant and equipment</td><td>17</td><td>8,933</td><td>9,932</td></tr><tr><td>Right of use assets</td><td>18</td><td>687</td><td>740</td></tr><tr><td>Goodwill</td><td>19</td><td>7,046</td><td>10,552</td></tr><tr><td>Other intangible assets</td><td>20</td><td>14,318</td><td>30,079</td></tr><tr><td>Investments in associates and joint ventures</td><td>21</td><td>74</td><td>88</td></tr><tr><td>Other investments</td><td>23</td><td>1,467</td><td>2,126</td></tr><tr><td>Deferred tax assets</td><td>14</td><td>5,658</td><td>5,218</td></tr><tr><td>Derivative financial instruments</td><td>44</td><td>-</td><td>18</td></tr><tr><td>Other non-current assets</td><td>24</td><td>1,194</td><td>1,676</td></tr><tr><td>Total non-current assets</td><td></td><td>39,377</td><td>60,429</td></tr><tr><td>Current assets</td><td></td><td></td><td></td></tr><tr><td>Inventories</td><td>25</td><td>5,146</td><td>5,783</td></tr><tr><td>Current tax recoverable</td><td>14</td><td>405</td><td>486</td></tr><tr><td>Trade and other receivables</td><td>26</td><td>7,053</td><td>7,860</td></tr><tr><td>Derivative financial instruments</td><td>44</td><td>190</td><td>188</td></tr><tr><td>Current equity investments</td><td>22</td><td>4,087</td><td>-</td></tr><tr><td>Liquid investments</td><td>30</td><td>67</td><td>61</td></tr><tr><td>Cash and cash equivalents</td><td>27</td><td>3,723</td><td>4,274</td></tr><tr><td>Assets held for sale</td><td>28</td><td>98</td><td>22</td></tr><tr><td>Total current assets</td><td></td><td>20,769</td><td>18,674</td></tr><tr><td>Total assets</td><td></td><td>60,146</td><td>79,103</td></tr><tr><td>Current liabilities</td><td></td><td></td><td></td></tr><tr><td>Short-term borrowings</td><td>30</td><td>(3,952)</td><td>(3,601)</td></tr><tr><td>Contingent consideration liabilities</td><td>33</td><td>(1,289)</td><td>(958)</td></tr><tr><td>Trade and other payables</td><td>29</td><td>(16,263)</td><td>(17,554)</td></tr><tr><td>Derivative financial instruments</td><td>44</td><td>(183)</td><td>(227)</td></tr><tr><td>Current tax payable</td><td>14</td><td>(471)</td><td>(489)</td></tr><tr><td>Short-term provisions</td><td>32</td><td>(652)</td><td>(841)</td></tr><tr><td>Total current liabilities</td><td></td><td>(22,810)</td><td>(23,670)</td></tr><tr><td>Non-current liabilities</td><td></td><td></td><td></td></tr><tr><td>Long-term borrowings</td><td>30</td><td>(17,035)</td><td>(20,572)</td></tr><tr><td>Corporation tax payable</td><td>14</td><td>(127)</td><td>(180)</td></tr><tr><td>Deferred tax liabilities</td><td>14</td><td>(289)</td><td>(3,556)</td></tr><tr><td>Pensions and other post-employment benefits</td><td>31</td><td>(2,579)</td><td>(3,113)</td></tr><tr><td>Other provisions</td><td>32</td><td>(532)</td><td>(630)</td></tr><tr><td>Derivative financial instruments</td><td>44</td><td>-</td><td>(1)</td></tr><tr><td>Contingent consideration liabilities</td><td>33</td><td>(5,779)</td><td>(5,118)</td></tr><tr><td>Other non-current liabilities</td><td>34</td><td>(899)</td><td>(921)</td></tr><tr><td>Total non-current liabilities</td><td></td><td>(27,240)</td><td>(34,091)</td></tr><tr><td>Total liabilities</td><td></td><td>(50,050)</td><td>(57,761)</td></tr><tr><td>Net assets</td><td></td><td>10,096</td><td>21,342</td></tr><tr><td>Equity</td><td></td><td></td><td></td></tr><tr><td>Share capital</td><td>37</td><td>1,347</td><td>1,347</td></tr><tr><td>Share premium account</td><td>37</td><td>3,440</td><td>3,301</td></tr><tr><td>Retained earnings</td><td>38</td><td>4,363</td><td>7,944</td></tr><tr><td>Other reserves</td><td>38</td><td>1,448</td><td>2,463</td></tr><tr><td>Shareholders&#x27; equity</td><td></td><td>10,598</td><td>15,055</td></tr><tr><td>Non-controlling interests</td><td></td><td>(502)</td><td>6,287</td></tr><tr><td>Total equity</td><td></td><td>10,096</td><td>21,342</td></tr></table>

The financial statements on pages 182 to 267 were approved by the Board on 9 March 2023 and signed on its behalf by

Sir Jonathan Symonds

Chair



## Consolidated statement of changes in equity for the year ended 31 December 2022

<table><tr><td rowspan="2"></td><td colspan="7">Shareholders&#x27; equity</td></tr><tr><td>Share capital £m</td><td>Share premium £m</td><td>Retained earnings £m</td><td>Other reserves* £m</td><td>Total £m</td><td>Non-controlling interests £m</td><td>Total equity £m</td></tr><tr><td>At 31 December 2019</td><td>1,346</td><td>3,174</td><td>4,530</td><td>2,355</td><td>11,405</td><td>6,952</td><td>18,357</td></tr><tr><td>Profit for the year</td><td>-</td><td>-</td><td>5,749</td><td>-</td><td>5,749</td><td>639</td><td>6,388</td></tr><tr><td>Other comprehensive (expense)/income for the year</td><td>-</td><td>-</td><td>(133)</td><td>1,137</td><td>1,004</td><td>(34)</td><td>970</td></tr><tr><td>Total comprehensive income for the year</td><td>-</td><td>-</td><td>5,616</td><td>1,137</td><td>6,753</td><td>605</td><td>7,358</td></tr><tr><td>Distributions to non-controlling interests</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>(1,208)</td><td>(1,208)</td></tr><tr><td>Contributions from non-controlling interests</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>3</td><td>3</td></tr><tr><td>Changes in non-controlling interests</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>(131)</td><td>(131)</td></tr><tr><td>Dividends to shareholders</td><td>-</td><td>-</td><td>(3,977)</td><td>-</td><td>(3,977)</td><td>-</td><td>(3,977</td></tr><tr><td>Realised profits after taxation on disposal of equity investments</td><td>-</td><td>-</td><td>163</td><td>(163)</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Share of associates and joint ventures realised profits on disposal of equity investments</td><td>-</td><td>-</td><td>44</td><td>(44)</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Shares issued</td><td>-</td><td>29</td><td>-</td><td>-</td><td>29</td><td>-</td><td>29</td></tr><tr><td>Shares acquired by ESOP Trusts</td><td>-</td><td>78</td><td>531</td><td>(609)</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Write-down of shares held by ESOP Trusts</td><td>-</td><td>-</td><td>(529)</td><td>529</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Share-based incentive plans</td><td>-</td><td>-</td><td>381</td><td>-</td><td>381</td><td>-</td><td>381</td></tr><tr><td>Tax on share-based incentive plans</td><td>-</td><td>-</td><td>(4)</td><td>-</td><td>(4)</td><td>-</td><td>(4)</td></tr><tr><td>At 31 December 2020</td><td>1,346</td><td>3,281</td><td>6,755</td><td>3,205</td><td>14,587</td><td>6,221</td><td>20,808</td></tr><tr><td>Profit for the year</td><td>-</td><td>-</td><td>4,385</td><td>-</td><td>4,385</td><td>711</td><td>5,096</td></tr><tr><td>Other comprehensive (expense)/income for the year</td><td>-</td><td>-</td><td>454</td><td>(771)</td><td>(317)</td><td>(20)</td><td>(337)</td></tr><tr><td>Total comprehensive income for the year</td><td>-</td><td>-</td><td>4,839</td><td>(771)</td><td>4,068</td><td>691</td><td>4,759</td></tr><tr><td>Distributions to non-controlling interests</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>(642)</td><td>(642)</td></tr><tr><td>Contributions from non-controlling interests</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>7</td><td>7</td></tr><tr><td>Dividends to shareholders</td><td>-</td><td>-</td><td>(3,999)</td><td>-</td><td>(3,999)</td><td>-</td><td>(3,999</td></tr><tr><td>Shares issued</td><td>1</td><td>20</td><td>-</td><td>-</td><td>21</td><td>-</td><td>21</td></tr><tr><td>Realised after tax profits on disposal of equity investments</td><td>-</td><td>-</td><td>132</td><td>(132)</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Share of associates and joint ventures realised profits on disposal of equity investments</td><td>-</td><td>-</td><td>7</td><td>(7)</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Write-down of shares held by ESOP Trusts</td><td>-</td><td>-</td><td>(168)</td><td>168</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Share-based incentive plans</td><td>-</td><td>-</td><td>367</td><td>-</td><td>367</td><td>-</td><td>367</td></tr><tr><td>Transaction with non-controlling interests</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>10</td><td>10</td></tr><tr><td>Tax on share-based incentive plans</td><td>-</td><td>-</td><td>11</td><td>-</td><td>11</td><td>-</td><td>11</td></tr><tr><td>At 31 December 2021</td><td>1,347</td><td>3,301</td><td>7,944</td><td>2,463</td><td>15,055</td><td>6,287</td><td>21,342</td></tr><tr><td>Profit for the year</td><td>-</td><td>-</td><td>14,956</td><td>-</td><td>14,956</td><td>665</td><td>15,621</td></tr><tr><td>Other comprehensive (expense)/income for the year</td><td>-</td><td>-</td><td>(89)</td><td>(714)</td><td>(803)</td><td>(28)</td><td>(831)</td></tr><tr><td>Total comprehensive income for the year</td><td>-</td><td>-</td><td>14,867</td><td>(714)</td><td>14,153</td><td>637</td><td>14,790</td></tr><tr><td>Distributions to non-controlling interests</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>(1,409)</td><td>(1,409</td></tr><tr><td>Non-cash distribution to non-controlling interests</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>(2,960)</td><td>(2,960</td></tr><tr><td>Contributions from non-controlling interests</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>8</td><td>8</td></tr><tr><td>Changes to non-controlling interests</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>(20)</td><td>(20</td></tr><tr><td>Deconsolidation of former subsidiaries</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>(3,045)</td><td>(3,045</td></tr><tr><td>Dividends to shareholders</td><td>-</td><td>-</td><td>(3,467)</td><td>-</td><td>(3,467)</td><td>-</td><td>(3,467</td></tr><tr><td>Non-cash dividend to shareholders</td><td>-</td><td>-</td><td>(15,526)</td><td>-</td><td>(15,526)</td><td>-</td><td>(15,526</td></tr><tr><td>Realised after tax losses on disposal or liquidation of equity investments</td><td>-</td><td>-</td><td>14</td><td>(14)</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Share of associates and joint ventures realised profits on disposal of equity investments</td><td>-</td><td>-</td><td>7</td><td>(7)</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Shares issued</td><td>-</td><td>25</td><td>-</td><td>-</td><td>25</td><td>-</td><td>25</td></tr><tr><td>Write-down of shares held by ESOP Trusts</td><td>-</td><td>-</td><td>(911)</td><td>911</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Shares acquired by ESOP Trusts</td><td>-</td><td>114</td><td>1,086</td><td>(1,200)</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Share-based incentive plans</td><td>-</td><td>-</td><td>357</td><td>-</td><td>357</td><td>-</td><td>357</td></tr><tr><td>Tax on share-based incentive plans</td><td>-</td><td>-</td><td>(8)</td><td>-</td><td>(8)</td><td>-</td><td>(8</td></tr><tr><td>Hedging gain after taxation transferred to non-financial assets</td><td>-</td><td>-</td><td>-</td><td>9</td><td>9</td><td>-</td><td>9</td></tr><tr><td>At 31 December 2022</td><td>1,347</td><td>3,440</td><td>4,363</td><td>1,448</td><td>10,598</td><td>(502)</td><td>10,096</td></tr></table>

* an analysis of Other reserves is presented as part of Note 38, 'Movements in equity'.



## Consolidated cash flow statement for the year ended 31 December 2022

<table><tr><td></td><td>Notes</td><td>2022
£m</td><td>2021(1)
£m</td><td>2020(1)
£m</td></tr><tr><td>Cash flow from operating activities</td><td></td><td></td><td></td><td></td></tr><tr><td>Profit after taxation from continuing operations for the year</td><td></td><td>4,921</td><td>3,516</td><td>5,103</td></tr><tr><td>Adjustments reconciling profit after tax to operating cash flows</td><td>42</td><td>3,023</td><td>3733</td><td>2,571</td></tr><tr><td>Cash generated from operations attributable to continuing operations</td><td></td><td>7944</td><td>7,249</td><td>7,674</td></tr><tr><td>Taxation paid</td><td></td><td>(1,310)</td><td>(972)</td><td>(1,086)</td></tr><tr><td>Net cash inflow from continuing operating activities</td><td></td><td>6,634</td><td>6,277</td><td>6,588</td></tr><tr><td>Cash generated from operations attributable to discontinued operations</td><td></td><td>932</td><td>1,994</td><td>2,422</td></tr><tr><td>Taxation paid from discontinued operations</td><td></td><td>(163)</td><td>(319)</td><td>(569)</td></tr><tr><td>Net operating cash flows attributable to discontinued operations</td><td></td><td>769</td><td>1,675</td><td>1,853</td></tr><tr><td>Total net cash inflows from operating activities</td><td></td><td>7,403</td><td>7,952</td><td>8,441</td></tr><tr><td>Cash flow from investing activities</td><td></td><td></td><td></td><td></td></tr><tr><td>Purchase of property, plant and equipment</td><td></td><td>(1,143)</td><td>(950)</td><td>(989)</td></tr><tr><td>Proceeds from sale of property, plant and equipment</td><td></td><td>146</td><td>132</td><td>49</td></tr><tr><td>Purchase of intangible assets</td><td></td><td>(1,115)</td><td>(1,704)</td><td>(956)</td></tr><tr><td>Proceeds from sale of intangible assets</td><td></td><td>196</td><td>641</td><td>343</td></tr><tr><td>Purchase of equity investments</td><td></td><td>(143)</td><td>(162)</td><td>(411)</td></tr><tr><td>Purchase of businesses, net of cash acquired</td><td>41</td><td>(3,108)</td><td>-</td><td>-</td></tr><tr><td>Proceeds from sale of equity investments</td><td></td><td>238</td><td>202</td><td>3,269</td></tr><tr><td>Contingent consideration paid</td><td></td><td>(79)</td><td>(114)</td><td>(120)</td></tr><tr><td>Disposal of businesses</td><td>41</td><td>(43)</td><td>(17)</td><td>117</td></tr><tr><td>Investments in associates and joint ventures</td><td>41</td><td>(1)</td><td>(1)</td><td>(4)</td></tr><tr><td>Proceeds from disposal of associates and joint ventures</td><td></td><td>-</td><td>277</td><td>-</td></tr><tr><td>Interest received</td><td></td><td>64</td><td>14</td><td>27</td></tr><tr><td>Decrease/(increase) in liquid investments</td><td></td><td>1</td><td>18</td><td>(1)</td></tr><tr><td>Dividends from associates and joint ventures</td><td></td><td>6</td><td>9</td><td>31</td></tr><tr><td>Net cash outflow from continuing investing activities</td><td></td><td>(4,981)</td><td>(1,655)</td><td>1,355</td></tr><tr><td>Net cash investing cash flows attributable to discontinued operations</td><td></td><td>(3,791)</td><td>(122)</td><td>806</td></tr><tr><td>Total net cash (outflow)/inflow from investing activities</td><td></td><td>(8,772)</td><td>(1,777)</td><td>2,161</td></tr><tr><td>Cash flow from financing activities</td><td></td><td></td><td></td><td></td></tr><tr><td>Issue of share capital</td><td>37</td><td>25</td><td>21</td><td>29</td></tr><tr><td>Repayment of long-term loans</td><td></td><td>(1,594)</td><td>-</td><td>-</td></tr><tr><td>Issue of long-term notes</td><td></td><td>1,025</td><td>-</td><td>3,298</td></tr><tr><td>Repayment of short-term loans</td><td></td><td>(5,074)</td><td>(2,304)</td><td>(3,738)</td></tr><tr><td>Increase in/(repayment of) other short-term loans</td><td></td><td>1,021</td><td>301</td><td>(3,594)</td></tr><tr><td>Repayment of lease liabilities</td><td></td><td>(202)</td><td>(181)</td><td>(182)</td></tr><tr><td>Interest paid</td><td></td><td>(848)</td><td>(772)</td><td>(851)</td></tr><tr><td>Dividends paid to shareholders</td><td></td><td>(3,467)</td><td>(3,999)</td><td>(3,977)</td></tr><tr><td>Distributions to non-controlling interests</td><td></td><td>(521)</td><td>(239)</td><td>(442)</td></tr><tr><td>Contributions from non-controlling interests</td><td></td><td>8</td><td>7</td><td>3</td></tr><tr><td>Other financing items</td><td></td><td>376</td><td>40</td><td>(89)</td></tr><tr><td>Net cash outflow from continuing financing activities</td><td></td><td>(9,251)</td><td>(7,126)</td><td>(9,543)</td></tr><tr><td>Net financing cash flows attributable to discontinued operations</td><td></td><td>10,074</td><td>(463)</td><td>(589)</td></tr><tr><td>Total net cash inflow/(outflow) from financing activities</td><td></td><td>823</td><td>(7,589)</td><td>(10,132)</td></tr><tr><td>(Increase)/decrease in cash and bank overdrafts</td><td>43</td><td>(546)</td><td>(1,414)</td><td>470</td></tr><tr><td>Cash and bank overdrafts at the beginning of year</td><td></td><td>3,819</td><td>5,262</td><td>4,831</td></tr><tr><td>Exchange adjustments</td><td></td><td>152</td><td>(29)</td><td>(39)</td></tr><tr><td>Increase/(Decrease) in cash and bank overdrafts in the year</td><td></td><td>(546)</td><td>(1,414)</td><td>470</td></tr><tr><td>Cash and bank overdrafts at the end of year</td><td></td><td>3,425</td><td>3,819</td><td>5,262</td></tr><tr><td>Cash and bank overdrafts at end of year comprise:</td><td></td><td></td><td></td><td></td></tr><tr><td>Cash and cash equivalents</td><td></td><td>3,723</td><td>4,274</td><td>6,292</td></tr><tr><td>Overdrafts</td><td></td><td>(298)</td><td>(455)</td><td>(1,030)</td></tr><tr><td></td><td></td><td>3,425</td><td>3,819</td><td>5,262</td></tr></table>

(1) The 2021 and 2020 comparative results have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see Note 4I).



# Notes to the financial statements

## 1. Presentation of the financial statements

## Description of business

GSK is a global biopharma group which makes innovative vaccines and specialty medicines to prevent and treat disease. GSK’s R&D focuses on the science of the immune system, human genetics and advanced technologies primarily in the following four therapeutic areas: infectious diseases, HIV, oncology and immunology/respiratory.

## Compliance with applicable law and IFRS

The financial statements have been prepared in accordance with international accounting standards in conformity with the requirements of the Companies Act 2006 and the International Financial Reporting Standards as issued by the IASB.

## Composition of financial statements

The consolidated financial statements are drawn up in Sterling, the functional currency of GSK plc, and in accordance with IFRS accounting presentation. The financial statements comprise:

– Consolidated income statement

– Consolidated statement of comprehensive income

– Consolidated balance sheet

– Consolidated statement of changes in equity

– Consolidated cash flow statement

– Notes to the financial statements.

## Composition of the Group

A list of the subsidiaries and associates which, in the opinion of the Directors, principally affected the amount of profit or net assets of the Group is given in Note 46, 'Principal Group companies'.

## Financial period

These financial statements cover the financial year from 1 January to 31 December 2022, with comparative figures for the financial years from 1 January to 31 December 2021 and, where appropriate, from 1 January to 31 December 2020. Income statement and cash flow comparatives have been restated on a consistent basis from those previously published to reflect the classification of the Consumer Healthcare business as a discontinued operation (see Note 41).

## Accounting principles and policies

The financial statements have been prepared using the historical cost convention modified by the revaluation of certain items, as stated in the accounting policies, and on a going concern basis.

The financial statements have been prepared in accordance with the Group’s accounting policies approved by the Board and described in Note 2, ‘Accounting principles and policies’. Information on the application of these accounting policies, including areas of estimation and judgement is given in Note 3, ‘Critical accounting judgements and key sources of estimation uncertainty’.

The preparation of the financial statements in conformity with generally accepted accounting principles requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates.

## Parent company financial statements

The financial statements of the parent company, GSK plc, have been prepared in accordance with UK GAAP and with UK accounting presentation. The company balance sheet is presented on page 268 and the accounting policies are given on pages 269 to 272.

## 2. Accounting principles and policies

## Consolidation

The consolidated financial statements include:

– the assets and liabilities, and the results and cash flows, of the company and its subsidiaries, including ESOP Trusts

– the Group’s share of the results and net assets of associates and joint ventures

– the Group’s share of assets, liabilities, revenue and expenses of joint operations.

The financial statements of entities consolidated are made up to 31 December each year.

Entities over which the Group has the power to direct the relevant activities so as to affect the returns to the Group, generally through control over the financial and operating policies, are accounted for as subsidiaries.
Where the Group has the ability to exercise joint control over, and rights to, the net assets of entities, the entities are accounted for as joint ventures. Where the Group has the ability to exercise joint control over an arrangement, but has rights to specified assets and obligations for specified liabilities of the arrangement, the arrangement is accounted for as a joint operation. Where the Group has the ability to exercise significant influence over entities, they are accounted for as associates. The results and assets and liabilities of associates and joint ventures are incorporated into the consolidated financial statements using the equity method of accounting. The assets, liabilities, revenue and expenses of joint operations are included in the consolidated financial statements in accordance with the Group’s rights and obligations.

Interests acquired in entities are consolidated from the date the Group acquires control and interests sold are de-consolidated from the date control ceases.



## Notes to the financial statements continued

## 2. Accounting principles and policies continued

Transactions and balances between subsidiaries are eliminated and no profit before tax is taken on sales between subsidiaries until the products are sold to customers outside the Group. The relevant proportion of profits on transactions with joint ventures, joint operations and associates is also deferred until the products are sold to third parties. Transactions with non-controlling interests are recorded directly in equity. Deferred tax relief on unrealised intra-Group profit is accounted for only to the extent that it is considered recoverable.

## Business combinations

Business combinations are accounted for using the acquisition accounting method. Identifiable assets, liabilities and contingent liabilities acquired are measured at fair value at acquisition date. The consideration transferred is measured at fair value and includes the fair value of any contingent consideration.

The fair value of contingent consideration liabilities is reassessed at each balance sheet date with changes recognised in the income statement. Payments of contingent consideration reduce the balance sheet liability and as a result are not recorded in the income statement.

The part of each payment relating to the original estimate of the fair value of the contingent consideration on acquisition is reported within investing activities in the cash flow statement and the part of each payment relating to the increase in the liability since the acquisition date is reported within operating cash flows.

Where the consideration transferred, together with the non-controlling interest, exceeds the fair value of the net assets, liabilities and contingent liabilities acquired, the excess is recorded as goodwill. The costs of effecting an acquisition are charged to the income statement in the period in which they are incurred.

Goodwill is capitalised as a separate item in the case of subsidiaries and as part of the cost of investment in the case of joint ventures and associates. Goodwill is denominated in the currency of the operation acquired.

Where the cost of acquisition is below the Group’s interest in the net assets acquired, the difference is recognised directly in the income statement.

Where not all of the equity of a subsidiary is acquired the non-controlling interest is recognised either at fair value or at the non-controlling interest's share of the net assets of the subsidiary, on a case-by-case basis. Changes in the Group's ownership percentage of subsidiaries are accounted for within equity.

## Foreign currency translation

Foreign currency transactions are booked in the functional currency of the Group company at the exchange rate ruling on the date of transaction. Foreign currency monetary assets and liabilities are retranslated into the functional currency at rates of exchange ruling at the balance sheet date. Exchange differences are included in the income statement.

On consolidation, assets and liabilities, including related goodwill, of overseas subsidiaries, associates and joint ventures, are translated into Sterling at rates of exchange ruling at the balance sheet date. The results and cash flows of overseas subsidiaries, associates and joint ventures are translated into Sterling using average rates of exchange. Exchange adjustments arising when the opening net assets and the profits for the year retained by overseas subsidiaries, associates and joint ventures are translated into Sterling, less exchange differences arising on related foreign currency borrowings which hedge the Group’s net investment in these operations, are taken to a separate component of equity within Retained Earnings.

When translating into Sterling the assets, liabilities, results and cash flows of overseas subsidiaries, associates and joint ventures which are reported in currencies of hyper-inflationary economies, adjustments are made where material to reflect current price levels. Any loss on net monetary assets is charged to the consolidated income statement.

## Revenue

## Turnover

The Group receives revenue for supply of goods to external customers against orders received. The majority of contracts that GSK enters into relate to sales orders containing single performance obligations for the delivery of pharmaceutical, vaccine and (prior to the demerger of the Consumer Healthcare business) consumer healthcare products. The average duration of a sales order is less than 12 months.

Product revenue is recognised when control of the goods is passed to the customer. The point at which control passes is determined by each customer arrangement, but generally occurs on delivery to the customer.

Product revenue represents net invoice value including fixed and variable consideration. Variable consideration arises on the sale of goods as a result of discounts and allowances given and accruals for estimated future returns and rebates. Revenue is not recognised in full until it is highly probable that a significant reversal in the amount of cumulative revenue recognised will not occur. The methodology and assumptions used to estimate rebates and returns are monitored and adjusted regularly in the light of contractual and legal obligations, historical trends, past experience and projected market conditions. Estimates associated with returns and rebates are revisited at each reporting date or when they are resolved and revenue is adjusted accordingly. Please refer to Note 3 for the details on rebates, discounts and allowances.

The Group has entered into collaborative agreements, typically with other pharmaceutical or biotechnology companies to develop, produce and market drug candidates and vaccines that do not qualify as joint arrangements. When GSK has control over the commercialisation activities, the Group recognises turnover and cost of sales on a gross basis. Profit sharing amounts and royalties due to the counterparty are recorded within cost of sales. Cost of sales includes profit sharing costs and royalties due to the counterparty of £1,635 million (2021: £640 million; 2020: £4 million). When the counterparty controls the commercialisation activities and records the sale, the Group is not deemed principal in the customer contract and instead records its share of gross profit as co-promotion income, on a net basis, within turnover. The nature of co-promotion activities is such that the Group records no costs of sales. Commercial Operations turnover includes co-promotion revenue of £3 million (2021: £7 million; 2020: £12 million). Reimbursements to and from the counterparty under collaboration agreements for 'selling, general and administration' and 'research and development' costs are recorded net in the respective lines in the Consolidated income statement.



## Notes to the financial statements continued

## 2. Accounting principles and policies continued

## Other operating income and royalty income

GSK enters into development and marketing collaborations and out-licences of the Group’s compounds or products to other parties. These contracts give rise to fixed and variable consideration from upfront payments, development milestones, sales-based milestones and royalties.

Income dependent on the achievement of a development milestone is recognised when it is highly probable that a significant reversal in the amount of cumulative revenue recognised will not occur, which is usually when the related event occurs. Sales-based milestone income is recognised when it is highly probable that the sales threshold will be reached.

Sales-based royalties on a licence of intellectual property are not recognised until the relevant product sale occurs.

For all revenue, if the time between the recognition of revenue and payment from the customer is expected to be more than one year and the impact is material, the amount of consideration is discounted using appropriate discount rates.

Value added tax and other sales taxes are excluded from revenue.

## Expenditure

Expenditure is recognised in respect of goods and services received when supplied in accordance with contractual terms. Provision is made when an obligation exists for a future liability in respect of a past event and where the amount of the obligation can be reliably estimated. Manufacturing start-up costs between validation and the achievement of normal production are expensed as incurred.

Advertising and promotion expenditure is charged to the income statement as incurred.

Shipment costs on inter-company transfers are charged to cost of sales; distribution costs on sales to customers are included in selling, general and administration expenditure.

Restructuring costs are recognised and provided for, where appropriate, in respect of the direct expenditure of a business reorganisation where the plans are sufficiently detailed and well advanced, and where appropriate communication to those affected has been undertaken.

Software as a service (SaaS) configuration costs are expensed as they are incurred where the software being configured is controlled by the SaaS provider.

## Research and development

Research and development expenditure is charged to the income statement in the period in which it is incurred. Development expenditure is capitalised when the criteria for recognising an asset are met, usually when a regulatory filing has been made in a major market and approval is considered highly probable. Property, plant and equipment used for research and development is capitalised and depreciated in accordance with the Group’s policy.

## Environmental expenditure

Environmental expenditure related to existing conditions resulting from past or current operations and from which no current or future benefit is discernible is charged to the income statement. The Group recognises its liability on a site-by-site basis when it can be reliably estimated.
This liability includes the Group’s portion of the total costs and also a portion of other potentially responsible parties’ costs when it is probable that they will not be able to satisfy their respective shares of the clean-up obligation. Recoveries of reimbursements are recorded as assets when virtually certain.

## Legal and other disputes

Provision is made for the anticipated settlement costs of legal or other disputes against the Group where an outflow of resources is considered probable and a reliable estimate can be made of the likely outcome. In respect of product liability claims related to certain products, provision is made when there is sufficient history of claims made and settlements to enable management to make a reliable estimate of the provision required to cover asserted and unasserted claims.

In certain cases, an incurred but not reported (IBNR) actuarial technique is used to determine this estimate. In addition, provision is made for legal or other expenses arising from claims received or other disputes.

The Group may become involved in legal proceedings, in respect of which it is not possible to meaningfully assess whether the outcome will result in a probable outflow, or to quantify or reliably estimate the liability. In these cases, appropriate disclosure about such cases is included but no provision is made.

Costs associated with claims made by the Group against third parties are charged to the income statement as they are incurred.

## Pensions and other post-employment benefits

The costs of providing pensions under defined benefit schemes are calculated using the projected unit credit method and spread over the period during which benefit is expected to be derived from the employees' services, consistent with the advice of qualified actuaries.

Pension obligations are measured as the present value of estimated future cash flows discounted at rates reflecting the yields of high-quality corporate bonds. Pension scheme assets are measured at fair value at the balance sheet date.

The costs of other post-employment liabilities are calculated in a similar way to defined benefit pension schemes and spread over the period during which benefit is expected to be derived from the employees' services, in accordance with the advice of qualified actuaries.

The service cost of providing retirement benefits to employees during the year, together with the cost of any curtailment, is charged to operating profit in the year.

Actuarial gains and losses and the effect of changes in actuarial assumptions are recognised in the statement of comprehensive income in the year in which they arise.

The Group’s contributions to defined contribution plans are charged to the income statement as incurred.



## Notes to the financial statements continued

## 2. Accounting principles and policies continued

## Employee share plans

Incentives in the form of shares are provided to employees under share option and share award schemes.

The fair values of these options and awards are calculated at their grant dates using a Black-Scholes option pricing model and charged to the income statement over the relevant vesting periods.

The Group provides finance to ESOP Trusts to purchase company shares to meet the obligation to provide shares when employees exercise their options or awards. Costs of running the ESOP Trusts are charged to the income statement.

Shares held by the ESOP Trusts are deducted from other reserves. A transfer is made between other reserves and retained earnings over the vesting periods of the related share options or awards to reflect the ultimate proceeds receivable from employees on exercise.

## Property, plant and equipment

Property, plant and equipment (PP&E) is stated at the cost of purchase or construction, less provisions for depreciation and impairment. Financing costs are capitalised within the cost of qualifying assets in construction.

Depreciation is calculated to write off the cost less residual value of PP&E, excluding freehold land, using the straight-line basis over the expected useful life. Residual values and lives are reviewed, and where appropriate adjusted annually. The normal expected useful lives of the major categories of PP&E are:

<table><tr><td>Freehold buildings</td><td>20 to 50 years</td></tr><tr><td>Leasehold land and buildings</td><td>Lease term or 20 to 50 years</td></tr><tr><td>Plant and machinery</td><td>10 to 20 years</td></tr><tr><td>Equipment and vehicles</td><td>3 to 10 years</td></tr></table>

On disposal of PP&E, the cost and related accumulated depreciation and impairments are removed from the financial statements and the net amount, less any proceeds, is taken to the income statement.

## Leases

The Group recognises right of use assets under lease arrangements in which it is the lessee, except for short-term leases (defined as leases with a lease term of 12 months or less) and leases of low value assets. Rights to use assets owned by third parties under lease agreements are capitalised at the inception of the lease and recognised on the consolidated balance sheet.

The corresponding liability to the lessor is recognised as a lease obligation within short and long-term borrowings. The carrying amount is subsequently increased to reflect interest on the lease liability and reduced by lease payments made.

For calculating the discounted lease liability on leases with annual payments of £2 million or more, the implicit rate in the lease is used. If this is not available, the incremental borrowing rate with a lease specific adjustment is used. If neither of these is available, and for leases with annual payments of less than £2 million, the incremental borrowing rate is used. The incremental borrowing rate is calculated at the rate of interest at which GSK would have been able to borrow for a similar term and with a similar security the funds necessary to obtain a similar asset in a similar market. Finance costs are charged to the income statement so as to produce a constant periodic rate of charge on the remaining balance of the obligations for each accounting period.

Variable rents are not part of the lease liability and the right of use asset. These payments are charged to the income statement as incurred. Lease rental costs for short-term and low-value leases which are not capitalised are also charged to the income statement as incurred.

Non-lease components are accounted for separately from the lease components in plant and equipment leases but are not separately accounted for in land and buildings or vehicle leases.

If modifications or reassessments of lease obligations occur, the lease liability and right of use asset are remeasured.

Right of use assets where title is expected to pass to GSK at a point in the future are depreciated on a basis consistent with similar owned assets. In other cases, right of use assets are depreciated over the shorter of the useful life of the asset or the lease term.

## Goodwill

Goodwill is stated at cost less impairments. Goodwill is deemed to have an indefinite useful life and is tested for impairment at least annually.

Where the fair value of the interest acquired in an entity’s assets, liabilities and contingent liabilities exceeds the consideration paid, this excess is recognised immediately as a gain in the income statement.

## Other intangible assets

Intangible assets are stated at cost less provisions for amortisation and impairments.

Licences, patents, know-how and marketing rights separately acquired or acquired as part of a business combination are amortised over their estimated useful lives, generally not exceeding 30 years, using the straight-line basis, from the time they are available for use. The estimated useful lives for determining the amortisation charge take into account patent lives (exclusivity period), where applicable, as well as the value obtained from periods of non-exclusivity. For Pharmaceutical intangible assets, depending on the characteristics, competitive environment and estimated long-term profits of the asset, between 80% to 90% of the book value is amortised over the exclusivity period on a straight-line basis and the remaining book value is amortised over a non-exclusivity period of 5-15 years on a straight-line basis. For Vaccines intangible assets, cost is usually amortised over the exclusivity period plus 10 years, or 30 years if no exclusivity period is granted, on a straight-line basis. Asset lives are reviewed, and where appropriate adjusted, annually.

Contingent milestone payments are recognised at the point that the contingent event becomes probable. Any development costs incurred by the Group and associated with acquired licences, patents, know-how or marketing rights are written off to the income statement when incurred, unless the criteria for recognition of an internally generated intangible asset are met, usually when a regulatory filing has been made in a major market and approval is considered highly probable.



## Notes to the financial statements continued

## 2. Accounting principles and policies continued

Acquired in process R&D and marketed products are valued independently as part of the fair value of businesses acquired from third parties where they have a value which is substantial and long term and where the brands either are contractual or legal in nature or can be sold separately from the rest of the businesses acquired.

The costs of acquiring and developing computer software for internal use and internet sites for external use are capitalised as intangible fixed assets where the software or site supports a significant business system and the expenditure leads to the creation of a durable asset controlled by the Group. ERP systems software is amortised over seven to ten years and other computer software over three to five years using the straight-line basis.

## Impairment of non-current assets

The carrying values of all non-current assets are reviewed for impairment, either on a stand-alone basis or as part of a larger cash generating unit, when there is an indication that the assets might be impaired. Additionally, goodwill and intangible assets which are not yet available for use are tested for impairment annually. Any provision for impairment is charged to the income statement in the year concerned.

Impairments of goodwill are not reversed. Impairment losses on other non-current assets are only reversed if there has been a change in estimates used to determine recoverable amounts and only to the extent that the revised recoverable amounts do not exceed the carrying values that would have existed, net of depreciation or amortisation, had no impairments been recognised.

## Investments in associates, joint ventures and joint operations

Investments in associates and joint ventures are carried in the consolidated balance sheet at the Group’s share of their net assets at date of acquisition and of their post-acquisition retained profits or losses and other comprehensive income together with any goodwill arising on the acquisition. The Group recognises the assets, liabilities, revenue and expenses of joint operations in accordance with its rights and obligations.

## Inventories

Inventories are included in the financial statements at the lower of cost (including raw materials, direct labour, other direct costs and related production overheads) and net realisable value. Cost is generally determined on a first in, first out basis. Pre-launch inventory is held as an asset when there is a high probability of regulatory approval for the product. Before that point a provision is made against the carrying value to reduce it to its recoverable amount; the provision is then reversed at the point when a high probability of regulatory approval is determined.

## Financial instruments

## Financial assets

Financial assets are measured at amortised cost, fair value through other comprehensive income (FVTOCI) or fair value through profit or loss (FVTPL). The measurement basis is determined by reference to both the business model for managing the financial asset and the contractual cash flow characteristics of the financial asset. For financial assets other than trade receivables a 12-month expected credit loss (ECL) allowance is recorded on initial recognition. If there is subsequent evidence of a significant increase in the credit risk of an asset, the allowance is increased to reflect the full lifetime ECL. If there is no realistic prospect of recovery, the asset is written off.

Expected credit losses are recognised in the income statement on financial assets measured at amortised cost and at fair value through other comprehensive income apart from equity investments.

## Current equity investments

Current equity investments comprise equity investments which the Group holds with the intention to sell and which it may sell in the short term. Where acquired with this intention, they are measured at FVTPL. They are initially recorded at fair value and then remeasured at subsequent reporting dates to fair value. Unrealised gains and losses are recognised in the income statement. Dividend income is recognised in the income statement when the Group’s right to receive payment is established. Purchases and sales of Current equity investments are accounted for on the trade date.

## Other investments

Other investments comprise equity investments and investments in limited life funds. The Group has elected to designate the majority of its equity investments as measured at FVTOCI. They are initially recorded at fair value plus transaction costs and then remeasured at subsequent reporting dates to fair value. Unrealised gains and losses are recognised in other comprehensive income. On disposal of the equity investment, gains and losses that have been deferred in other comprehensive income are transferred directly to retained earnings.

Investments in limited life funds are measured at FVTPL. They are initially recorded at fair value and then remeasured at subsequent reporting dates to fair value. Unrealised gains and losses are recognised in the income statement.

Dividends on equity investments and distributions from funds are recognised in the income statement when the Group’s right to receive payment is established.

Purchases and sales of Other investments are accounted for on the trade date.



## Notes to the financial statements continued

## 2. Accounting principles and policies continued

## Trade receivables

Trade receivables are measured in accordance with the business model under which each portfolio of trade receivables is held. The Group has portfolios in each of the three business models under IFRS 9: to collect the contractual cash flows where there is no factoring agreement in place (measured at amortised cost), to sell the contractual cash flows where the trade receivables will be sold under a factoring agreement (measured at FVTPL), and both to collect and to sell the contractual cash flows where the trade receivables may be sold under a factoring arrangement (measured at FVTOCI). Trade receivables measured at amortised cost are carried at the original invoice amount less allowances for expected credit losses.

Expected credit losses are calculated in accordance with the simplified approach permitted by IFRS 9, using a provision matrix applying lifetime historical credit loss experience to the trade receivables. The expected credit loss rate varies depending on whether, and the extent to which, settlement of the trade receivables is overdue and it is also adjusted as appropriate to reflect current economic conditions and estimates of future conditions. For the purpose of determining credit loss rates, customers are classified into groupings that have similar loss patterns. The key drivers of the loss rate are the nature of the business unit and the location and type of customer.

When a trade receivable is determined to have no reasonable expectation of recovery it is written off, firstly against any expected credit loss allowance available and then to the income statement.

Subsequent recoveries of amounts previously provided for or written off are credited to the income statement. Long-term receivables are discounted where the effect is material.

## Cash and cash equivalents

Cash held in deposit accounts is measured at amortised cost. Investments in money market funds are held at fair value through profit or loss because the funds fail the solely payments of principal and interest (SPPI) test.

## Borrowings

All borrowings are initially recorded at the amount of proceeds received, net of transaction costs. Borrowings are subsequently carried at amortised cost, with the difference between the proceeds, net of transaction costs, and the amount due on redemption being recognised as a charge to the income statement over the period of the relevant borrowing.

## Derivative financial instruments

Derivative financial instruments are used to manage exposure to market risks. The principal derivative instruments used by GSK are foreign currency swaps, interest rate swaps, foreign exchange forward contracts and options. The Group does not hold or issue derivative financial instruments for trading or speculative purposes.

Derivative financial assets and liabilities, including derivatives embedded in host contracts which have been separated from the host contract, are classified as held-for-trading and are measured at fair value. Changes in the fair value of any derivative instruments that do not qualify for hedge accounting are recognised immediately in the income statement.

## Hedge accounting

Derivatives designated as hedging instruments are classified at inception of hedge relationship as cash flow hedges, net investment hedges or fair value hedges.

Changes in the fair value of derivatives designated as cash flow hedges are recognised in other comprehensive income to the extent that the hedges are effective and accumulated in the cash flow hedge reserve. Ineffective portions are recognised in profit or loss immediately. Amounts deferred in the cash flow hedge reserve are reclassified to the income statement when the hedged item affects profit or loss, or if the hedged forecast transaction is to purchase a non-financial asset, the amount deferred in the cash flow hedge reserve is transferred directly from equity and included in the carrying value of the recognised non-financial asset.

Net investment hedges are accounted for in a similar way to cash flow hedges which are reclassified to the income statement when the hedged item affects profit or loss.

Changes in the fair value of derivatives designated as fair value hedges are recorded in the income statement, together with the changes in the fair value of the hedged asset or liability.

## Taxation

Current tax is provided at the amounts expected to be paid, applying tax rates that have been enacted or substantively enacted by the balance sheet date. The tax charge for the period is recognised in the income statement, the statement of comprehensive income or directly in equity, according to the accounting treatment of the related transaction.

Deferred tax is provided in full on temporary differences arising between the tax bases of assets and liabilities and their carrying amounts in the financial statements. Deferred tax assets are recognised to the extent that it is probable that future taxable profits will be available against which the temporary differences can be utilised. Deferred tax is provided on temporary differences arising on investments in subsidiaries, associates and joint ventures, except where the timing of the reversal of the temporary difference can be controlled and it is probable that the temporary difference will not reverse in the foreseeable future. Deferred tax is provided using rates of tax that have been enacted or substantively enacted by the balance sheet date. Deferred tax assets and liabilities are offset when there is a legally enforceable right to offset current tax assets against current tax liabilities and when they relate to income taxes levied by the same tax authority and the Company and its subsidiaries intend to settle their current tax assets and liabilities on a net basis.

Deferred tax assets and liabilities are not recognised if the temporary differences arise from the initial recognition of goodwill or from the initial recognition of other assets and liabilities in a transaction (other than a business combination) that affects neither the accounting nor the taxable profit or loss. Unrecognised deferred tax assets are reassessed at each reporting date and are recognised to the extent that it has become probable that future taxable profits will allow the deferred tax asset to be recovered.



## Notes to the financial statements continued

## 2. Accounting principles and policies continued

Where an uncertain tax position is identified, management will make a judgement as to what the probable outcome will be, assuming the relevant tax authority has full knowledge of the situation. Where it is assessed that an economic outflow is probable to arise, a provision is made for the best estimate of the liability. In estimating any such liability GSK applies a risk-based approach which takes into account, as appropriate, the probability that the Group would be able to obtain compensatory adjustments under international tax treaties. These estimates take into account the specific circumstances of each dispute and relevant external advice.

## Discounting

Where the time value of money is material, balances are discounted to current values using appropriate discount rates. The unwinding of the discounts is recorded in finance income and finance expense.

## Assets and liabilities held for sale or distribution and discontinued operations

Disposal groups are classified as held for sale or distribution if their carrying amount will be recovered principally through sale or a distribution to shareholders rather than through continuing use, they are available for sale or distribution in their present condition and the sale or distribution is considered highly probable. Assets held in Assets held for sale or distribution are measured at the lower of their carrying amount and fair value less costs to sell or distribute. Non-current assets included in Assets held for sale or distribution are not depreciated or amortised. Assets and liabilities classified as held for sale or distribution are presented in current assets and current liabilities separately from the other assets and liabilities in the balance sheet.

A discontinued operation is a component of the Group that has been disposed of, distributed or is classified as held for sale or distribution and that represents a separate major line of business. The results of discontinued operations are presented separately in the Consolidated income statement, the Consolidated statement of other comprehensive income and the Consolidated statement of cash flows and comparatives are restated on a consistent basis.

## 3. Critical accounting judgements and key sources of estimation uncertainty

In preparing the financial statements, management is required to make judgements about when or how items should be recognised in the financial statements and estimates and assumptions that affect the amounts of assets, liabilities, revenue and expenses reported in the financial statements. Actual amounts and results could differ from those estimates. The following are considered to be the critical accounting judgements and key sources of estimation uncertainty.

## Turnover

Reported Group turnover for 2022 was £29,324 million (2021 \( ^{(1)} $ : £24,696 million).

## Estimates

Gross turnover is reduced by rebates, discounts, allowances and product returns given or expected to be given, which vary by product arrangements and buying groups. These arrangements with purchasing organisations are dependent upon the submission of claims some time after the initial recognition of the sale. Accruals are made at the time of sale for the estimated rebates, discounts or allowances payable or returns to be made, based on available market information and historical experience.
Sales of pharmaceutical and vaccine products in the US have complex arrangements for rebates, discounts and allowances. Turnover of Commercial Operations products in the US for 2022 of £14,542 million (2021: £11,914 million) was after recording deductions of £15,272 million (2021: £12,518 million) for rebates, allowances, returns and other discounts. At 31 December 2022, the total accrual amounted to £5,855 million (2021: £5,044 million). Due to the nature of these accruals it is not practicable to give meaningful sensitivity estimates due to the large volume of variables that contribute to the overall rebates, chargebacks, returns and other revenue accruals.

As there can be significant variability in final outcomes, the Group applies a constraint when measuring the variable element within revenue, so that revenue is recognised at a suitably cautious amount. The objective of the constraint is to ensure that it is highly probable that a significant reversal of revenue will not occur when the uncertainties are resolved. The constraint is applied by making suitably cautious estimates of the inputs and assumptions used in estimating the variable consideration. Because the amounts are estimated they may not fully reflect the final outcome, and the amounts are subject to change dependent upon, amongst other things, the types of buying group and product sales mix. The constraints applied in recognising revenue mean that the risk of a material downward adjustment to revenue in the next financial year is low.



## Notes to the financial statements continued

3. Critical accounting judgements and key sources of estimation uncertainty continued

The level of accrual for rebates and returns is reviewed and adjusted regularly in the light of contractual and legal obligations, historical trends, past experience and projected market conditions. Market conditions are evaluated using wholesaler and other third-party analyses, market research data and internally generated information. It is reasonably possible that there could be a significant adjustment within the next 12 months to recognise additional revenue, if actual outcomes are better than the cautious constrained estimates.

Revenue is not recognised in full until it is highly probable that a significant reversal in the amount of cumulative revenue recognised will not occur. The amount of turnover recognised in the year from performance obligations satisfied in previous periods is set out in Note 6, 'Turnover and segment information', and is an indication of the level of sensitivity in the estimate.

Future events could cause the assumptions on which the accruals are based to change, which could materially affect the future results of the Group.

## Taxation

The tax charge for the year was £707 million (2021 \( ^{[1]} $ : £83 million). At December 2022, current tax payable was £471 million (2021: £489 million), non-current corporation tax payable was £127 million (2021: £180 million) and current tax recoverable was £405 million (2021: £486 million).

## Estimates

The Group has open tax issues with a number of revenue authorities. Management makes a judgement of whether there is sufficient information to be able to make a reliable estimate of the outcome of the dispute. If insufficient information is available, no provision is made.

If sufficient information is available, in estimating a potential tax liability GSK applies a risk-based approach which takes into account, as appropriate, the probability that the Group would be able to obtain compensatory adjustments under international tax treaties. These estimates take into account the specific circumstances of each dispute and relevant external advice, are inherently judgemental and could change substantially over time as each dispute progresses and new facts emerge.

At 31 December 2022, the Group had recognised provisions of £551 million in respect of uncertain tax positions (2021: £858 million). Due to the number of uncertain tax positions held and the number of jurisdictions to which these relate, it is not practicable to give meaningful sensitivity estimates. No uncertain tax position is individually significant to the Group.

Factors affecting the tax charge in future years are set out in Note 14, 'Taxation'. GSK continues to believe that it has made adequate provision for the liabilities likely to arise from open assessments. Where open issues exist, the ultimate liability for such matters may vary from the amounts provided and is dependent upon the outcome of negotiations with the relevant tax authorities or, if necessary, litigation proceedings.

## Legal and other disputes

Legal costs for the year were £144 million (2021 \( ^{[1]} $ : £50 million). At 31 December 2022 provisions for legal and other disputes amounted to £218 million (2021: £196 million).

## Estimates

Management makes a judgement of whether there is sufficient information to be able to make a reliable estimate of the likely outcome of the dispute and the legal and other expenses arising from claims against the Group. If insufficient information is available, no provision is made and disclosure of the claim is given.

The estimated provisions take into account the specific circumstances of each dispute and relevant external advice, are inherently judgemental and could change substantially over time as each dispute progresses and new facts emerge. Details of the status and various uncertainties involved in the significant unresolved disputes are set out in Note 47, 'Legal proceedings'.

The company’s Directors, having taken legal advice, have established provisions after taking into account the relevant facts and circumstances of each matter and in accordance with accounting requirements. In respect of product liability claims related to certain products, there is sufficient history of claims made and settlements to enable management to make a reliable estimate of the provision required to cover unasserted claims.

The Group may become involved in legal proceedings, in respect of which it is not possible to meaningfully assess whether the outcome will result in a probable outflow, or to quantify or reliably estimate the liability. In these cases, appropriate disclosure about such cases would be provided, but no provision would be made and no contingent liability can be quantified.

The ultimate liability for legal claims may vary from the amounts provided and is dependent upon the outcome of litigation proceedings, investigations and possible settlement negotiations. The position could change over time and, therefore, there can be no assurance that any losses that result from the outcome of any legal proceedings will not exceed the amount of the provisions reported in the Group’s financial statements by a material amount.

## Contingent consideration

The 2022 income statement charge for contingent consideration was £1,645 million (2021: £1,063 million).

At 31 December 2022, the liability for contingent consideration amounted to £7,068 million (2021: £6,076 million). Of this amount, £5,890 million (2021: £5,559 million) related to the acquisition of the former Shionogi-ViiV Healthcare joint venture in 2012.

## Estimates

Any contingent consideration included in the consideration payable for a business combination is recorded at fair value at the date of acquisition. These fair values are generally based on risk-adjusted future cash flows discounted using appropriate post-tax discount rates. The fair values are reviewed on a regular basis, at least annually, and any changes are reflected in the income statement. See Note 33, 'Contingent consideration liabilities'.



## Notes to the financial statements continued

3. Critical accounting judgements and key sources of estimation uncertainty continued

## Pensions and other post-employment benefits

## Judgement

Where a surplus on a defined benefit scheme arises, or there is potential for a surplus to arise from committed future contributions, the rights of the Trustees to prevent the Group obtaining a refund of that surplus in the future are considered in determining whether it is necessary to restrict the amount of the surplus that is recognised. Two UK schemes are in surplus (2021: three UK schemes), with a combined surplus of £109 million at 31 December 2022 (2021: £606 million). There are further recognised pension surpluses totalling £120 million spread across five countries (2021: £135 million across six countries). GSK has made the judgement that these amounts meet the requirements of recoverability.

## Estimates

The costs of providing pensions and other post-employment benefits are assessed on the basis of assumptions selected by management. These assumptions include future earnings and pension increases, discount rates, expected long-term rates of return on assets and mortality rates, and are disclosed in Note 31, 'Pensions and other post-employment benefits'.
Discount rates are derived from AA rated corporate bond yields except in countries where there is no deep market in corporate bonds where government bond yields are used. A sensitivity analysis is provided in Note 31, 'Pensions and other post-employment benefits', a 0.25% reduction in the discount rate would lead to an increase in the net pension deficit of approximately £424 million and an increase in the annual pension cost of approximately £19 million. Similarly, a 0.25% increase in the discount rate would lead to a decrease in the net pension deficit of approximately £400 million and a decrease in the annual pension cost of approximately £19 million. A 0.75% reduction in the discount rate would lead to an increase in the net pension deficit of approximately £1,341 million and an increase in the annual pension cost of approximately £52 million. Similarly, a 0.75% increase in the discount rate would lead to a decrease in the net pension deficit of approximately £1,147 million and a decrease in the annual pension cost of approximately £60 million. The selection of different assumptions could affect the future results of the Group.

## 4. New accounting requirements

Amendments to accounting standards issued by the IASB and adopted in the year ended 31 December 2022 did not have a material impact on the results or financial position of the Group. Certain new accounting standards, amendments to accounting standards and interpretations have been published that are not mandatory for 31 December 2022 reporting periods and have not been adopted early by the Group. These standards, amendments and interpretations are not expected to have a material impact on the results or financial position of the Group in future reporting periods.

## 5. Exchange rates

The Group uses the average of exchange rates prevailing during the period to translate the results and cash flows of overseas subsidiaries, joint ventures and associates into Sterling and period end rates to translate the net assets of those entities. The currencies which most influence these translations and the relevant exchange rates were:

<table><tr><td></td><td>2022</td><td>2021</td><td>2020</td><td></td><td>2022</td><td>2021</td><td>2020</td></tr><tr><td>Average rates:</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>US\(/£</td><td>1.24</td><td>1.38</td><td>1.29</td><td>Period end rates:</td><td></td><td></td><td></td></tr><tr><td>Euro/£</td><td>1.17</td><td>1.16</td><td>1.13</td><td>US\)/£</td><td>1.20</td><td>1.35</td><td>1.36</td></tr><tr><td>Yen/£</td><td>161</td><td>151</td><td>137</td><td>Euro/£</td><td>1.13</td><td>1.19</td><td>1.11</td></tr></table>



## 6. Turnover and segment information

Operating segments are reported based on the financial information provided to the Chief Executive Officer and the responsibilities of the GSK Leadership Team (GLT). GSK has revised its operating segments from Q1 2022 and from Q2 2022. Previously GSK reported results under four segments: Pharmaceuticals, Pharmaceuticals R&D, Vaccines and Consumer Healthcare. For the first quarter 2022, GSK reported results under three segments: Commercial Operations, Total R&D and Consumer Healthcare. From Q2 2022, GSK reports under two segments from continuing operations as the demerger of the Consumer Healthcare segment was completed on 18 July 2022. Members of the GLT are responsible for each segment. Comparative information has been retrospectively revised on a consistent basis.

R&D investment is essential for the sustainability of the business. However for segment reporting the Commercial Operating profits exclude allocations of globally funded R&D.

The Total R&D segment is the responsibility of the Chief Scientific Officer and is reported as a separate segment. The operating costs of this segment includes R&D activities across Specialty Medicines, including HIV and Vaccines. It includes R&D and some SG&A costs relating to regulatory and other functions.

The Group’s management reporting process allocates intra-Group profit on a product sale to the segment in which that sale is recorded, and the profit analyses below have been presented on that basis.

<table><tr><td>Turnover by segment</td><td>2022
£m</td><td>2021
(revised)
£m</td><td>2020
(revised)
£m</td></tr><tr><td>Commercial operations</td><td>29,324</td><td>24,696</td><td>24,232</td></tr><tr><td>Consumer Healthcare</td><td>-</td><td>-</td><td>122</td></tr><tr><td></td><td>29,324</td><td>24,696</td><td>24,354</td></tr></table>

On 1 April 2020, GSK completed its divestment of Horlicks and other Consumer Healthcare nutrition products in India and a number of other countries (excluding Bangladesh) to Unilever and the merger of GSK's Indian listed Consumer Healthcare entity with Hindustan Unilever, an Indian listed company. GSK completed the divestment of Bangladesh on 30 June 2020.

This business was excluded from the Consumer Healthcare Joint Venture but was included in the Consumer Healthcare segment performance in 2020.

For 2022, product sales are reported within three product groups: Specialty Medicines, Vaccines and General Medicines.

<table><tr><td>Commercial Operations:</td><td>2022</td><td>2021(1)</td><td>2020(1)</td></tr><tr><td></td><td>£m</td><td>(revised)</td><td>(revised)</td></tr><tr><td></td><td></td><td>£m</td><td>£m</td></tr><tr><td>HIV</td><td>5,749</td><td>4,777</td><td>4,876</td></tr><tr><td>Oncology</td><td>602</td><td>489</td><td>372</td></tr><tr><td>Immuno-inflammation, respiratory and other</td><td>2,609</td><td>2,027</td><td>1,721</td></tr><tr><td></td><td>8,960</td><td>7,293</td><td>6,969</td></tr><tr><td>Pandemic</td><td>2,309</td><td>958</td><td>-</td></tr><tr><td>Specialty Medicines</td><td>11,269</td><td>8,251</td><td>6,969</td></tr><tr><td>Meningitis</td><td>1,116</td><td>961</td><td>1,029</td></tr><tr><td>Influenza</td><td>714</td><td>679</td><td>733</td></tr><tr><td>Shingles</td><td>2,958</td><td>1,721</td><td>1,989</td></tr><tr><td>Established Vaccines</td><td>3,085</td><td>2,970</td><td>3,231</td></tr><tr><td></td><td>7,873</td><td>6,331</td><td>6,982</td></tr><tr><td>Pandemic Vaccines</td><td>64</td><td>447</td><td>-</td></tr><tr><td>Vaccines</td><td>7,937</td><td>6,778</td><td>6,982</td></tr><tr><td>Respiratory</td><td>6,548</td><td>6,048</td><td>6,006</td></tr><tr><td>Other General Medicines</td><td>3,570</td><td>3,619</td><td>4,275</td></tr><tr><td>General Medicines</td><td>10,118</td><td>9,667</td><td>10,281</td></tr><tr><td>Total Commercial Operations</td><td>29,324</td><td>24,696</td><td>24,232</td></tr><tr><td>Total Consumer Healthcare</td><td>-</td><td>-</td><td>122</td></tr></table>

(1) The 2021 and 2020 comparatives have been revised to reflect the Commercial Operations segment.



## Notes to the financial statements continued

## 6. Turnover and segment information continued

During 2022, sales were made to three US wholesalers of £4,045 million (2021: £3,159 million; 2020: £2,928 million), £4,161 million (2021: £3,081 million; 2020: £3,085 million) and £3,227 million (2021: £2,670 million; 2020: £2,795 million) respectively, after allocating final-customer discounts to the wholesalers.

Revenue recognised in the year from performance obligations satisfied in previous periods totalled £1,601 million (2021 \( ^{(1)} $ : £1,438 million) including £898 million (2021 \( ^{(1)} $ : £949 million) impacting turnover arising from changes to prior year estimates of RAR (returns and rebates) accruals, £115 million (2021: £61 million) of milestone income and £588 million (2021: £428 million) of royalty income recognised in the current year.

<table><tr><td>Segment profit</td><td>2022
£m</td><td>2021(1)
(revised)
£m</td><td>2020(1)
(revised)
£m</td></tr><tr><td>Commercial Operations</td><td>13,590</td><td>11,467</td><td>11,297</td></tr><tr><td>Research and development</td><td>(5,060)</td><td>(4,567)</td><td>(4,397)</td></tr><tr><td>Consumer Healthcare</td><td>-</td><td>-</td><td>55</td></tr><tr><td>Segment profit</td><td>8,530</td><td>6,900</td><td>6,955</td></tr><tr><td>Corporate and other unallocated costs</td><td>(379)</td><td>(407)</td><td>(299)</td></tr><tr><td>Other reconciling items between segment profit and operating profit</td><td>(1,718)</td><td>(2,136)</td><td>(677)</td></tr><tr><td>Total Operating profit</td><td>6,433</td><td>4,357</td><td>5,979</td></tr><tr><td>Finance income</td><td>76</td><td>14</td><td>32</td></tr><tr><td>Finance costs</td><td>(879)</td><td>(769)</td><td>(874)</td></tr><tr><td>Loss on disposal of interest in associates</td><td>-</td><td>(36)</td><td>-</td></tr><tr><td>Share of after-tax profits/(losses) of associates and joint ventures</td><td>(2)</td><td>33</td><td>33</td></tr><tr><td>Profit before taxation from continuing operations</td><td>5,628</td><td>3,599</td><td>5,170</td></tr><tr><td>Taxation</td><td>(707)</td><td>(83)</td><td>(67)</td></tr><tr><td>Profit after taxation for the year from continuing operations</td><td>4,921</td><td>3,516</td><td>5,103</td></tr></table>

On 1 April 2020, GSK completed its divestment of Horlicks and other Consumer Healthcare nutrition products in India and a number of other countries (excluding Bangladesh) to Unilever and the merger of GSK's Indian listed Consumer Healthcare entity with Hindustan Unilever, an Indian listed company. GSK completed the divestment of Bangladesh on 30 June 2020.

Other reconciling items between segment profit and operating profit comprise items not specifically allocated to segment profit. These include impairment and amortisation of intangible assets; major restructuring costs, which include impairments of tangible assets and computer software; transaction-related adjustments related to significant acquisitions; proceeds and costs of disposals of products and businesses, significant legal charges and expenses on the settlement of litigation and government investigations, other operating income other than royalty income and other items. Please refer to the detail of Other reconciling items between segment profit and operating profit in the analysis of adjusting items (Group financial review).

<table><tr><td>Depreciation and amortisation by segment</td><td>2022
£m</td><td>2021(1)
(revised)
£m</td><td>2020(1)
(revised)
£m</td></tr><tr><td>Commercial Operations</td><td>829</td><td>915</td><td>904</td></tr><tr><td>Research and development</td><td>467</td><td>378</td><td>355</td></tr><tr><td>Segment depreciation and amortisation</td><td>1,296</td><td>1,293</td><td>1,259</td></tr><tr><td>Corporate and other unallocated depreciation and amortisation</td><td>112</td><td>68</td><td>67</td></tr><tr><td>Other reconciling items between segment depreciation and amortisation and total depreciation and amortisation</td><td>739</td><td>761</td><td>724</td></tr><tr><td>Total depreciation and amortisation</td><td>2,147</td><td>2,122</td><td>2,050</td></tr></table>

(1) The 2021 and 2020 comparatives have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see Note 4).



## Notes to the financial statements continued

## 6. Turnover and segment information continued

<table><tr><td>PP&E, intangible asset and goodwill impairment by segment</td><td>2022 £m</td><td>2021(revised) \( ^{2} \)  £m</td><td>2020(revised) \( ^{2} \)  £m</td></tr><tr><td>Commercial Operations</td><td>29</td><td>30</td><td>87</td></tr><tr><td>Research and development</td><td>32</td><td>55</td><td>37</td></tr><tr><td>Segment impairment</td><td>61</td><td>85</td><td>124</td></tr><tr><td>Corporate and other unallocated impairment</td><td>20</td><td>63</td><td>5</td></tr><tr><td>Other reconciling items between segment impairment and total impairment</td><td>420</td><td>392</td><td>583</td></tr><tr><td>Total impairment</td><td>501</td><td>540</td><td>712</td></tr></table>

## PP&E and intangible asset impairment reversals by segment

<table><tr><td>Commercial Operations</td><td>(6)</td><td>(8)</td><td>(14)</td></tr><tr><td>Research and development</td><td>(19)</td><td>(2)</td><td>(4)</td></tr><tr><td>Segment impairment reversals</td><td>(25)</td><td>(10)</td><td>(18)</td></tr><tr><td>Corporate and other unallocated impairment reversals</td><td>-</td><td>-</td><td>(1)</td></tr><tr><td>Other reconciling items between segment impairment reversals and total impairment reversals</td><td>(1)</td><td>(2)</td><td>(35)</td></tr><tr><td>Total impairment reversals</td><td>(26)</td><td>(12)</td><td>(54)</td></tr></table>

<table><tr><td>Net operating assets by segment</td><td>2022 £m</td><td>2021 (revised) \( ^{2} \)  £m</td></tr><tr><td>Commercial Operations</td><td>10,288</td><td>9,440</td></tr><tr><td>Research and development</td><td>7,299</td><td>3,461</td></tr><tr><td>Segment net operating assets</td><td>17,587</td><td>12,901</td></tr><tr><td>Corporate and other unallocated net operating assets</td><td>264</td><td>1,504</td></tr><tr><td>Discontinued operations</td><td>-</td><td>25,208</td></tr><tr><td>Net operating assets</td><td>17,851</td><td>39,613</td></tr><tr><td>Net debt</td><td>(17,197)</td><td>(19,838)</td></tr><tr><td>Investments in associates and joint ventures</td><td>74</td><td>88</td></tr><tr><td>Current Equity Investment</td><td>4,087</td><td>-</td></tr><tr><td>Derivative financial instruments</td><td>7</td><td>(22)</td></tr><tr><td>Current and deferred taxation</td><td>5,176</td><td>1,479</td></tr><tr><td>Assets held for sale (excluding cash and cash equivalents)</td><td>98</td><td>22</td></tr><tr><td>Net assets</td><td>10,096</td><td>21,342</td></tr></table>

The Commercial Operations segment includes the Shionogi-ViV Healthcare contingent consideration liability of £5,890 million (2021: £5,559 million) and the Pfizer put option of £1,093 million (2021: £1,008 million).

## Geographical information

The UK is regarded as being the Group’s country of domicile.

<table><tr><td>Turnover by location of customer</td><td>2022 £m</td><td>2021(revised) \( ^{2} \)  £m</td><td>2020(revised) \( ^{2} \)  £m</td></tr><tr><td>UK</td><td>695</td><td>656</td><td>659</td></tr><tr><td>US</td><td>14,542</td><td>11,914</td><td>11,148</td></tr><tr><td>Rest of World</td><td>14,087</td><td>12,126</td><td>12,547</td></tr><tr><td>External turnover</td><td>29,324</td><td>24,696</td><td>24,354</td></tr></table>

<table><tr><td>Non-current assets by location of subsidiary</td><td>2022 £m</td><td>2021 £m</td></tr><tr><td>UK</td><td>5,134</td><td>6,618</td></tr><tr><td>US</td><td>14,024</td><td>17,852</td></tr><tr><td>Belgium</td><td>5,415</td><td>5,065</td></tr><tr><td>Switzerland</td><td>34</td><td>6,552</td></tr><tr><td>Rest of World</td><td>6,559</td><td>15,390</td></tr><tr><td>Non-current assets</td><td>31,166</td><td>51,477</td></tr></table>

Non-current assets by location excludes amounts relating to other investments, deferred tax assets, derivative financial instruments, pension assets, amounts receivable under insurance contracts and certain other non-current receivables. There are no other countries with individually material external revenue or non-current assets.

(1) The 2021 and 2020 comparatives have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see Note 4I).

(2) The 2021 and 2020 comparatives have been revised to reflect the new segments.



## 7. Other operating income/(expense)

<table><tr><td></td><td>2022
£m</td><td>2021(1)
£m</td><td>2020(1)
£m</td></tr><tr><td>Upfront settlement income(2)</td><td>922</td><td>-</td><td>-</td></tr><tr><td>Fair value remeasurements of equity investments</td><td>256</td><td>37</td><td>(6)</td></tr><tr><td>Disposal of businesses and assets</td><td>215</td><td>552</td><td>2,621</td></tr><tr><td>Fair value remeasurements on contingent consideration recognised in business combinations</td><td>(1,607)</td><td>(1,058)</td><td>(1,286)</td></tr><tr><td>Remeasurement of ViiV Healthcare put option liabilities and preferential dividends</td><td>(85)</td><td>(48)</td><td>52</td></tr><tr><td>Fair value adjustments on derivative financial instruments</td><td>3</td><td>(4)</td><td>20</td></tr><tr><td>Other income</td><td>61</td><td>17</td><td>62</td></tr><tr><td></td><td>(235)</td><td>(504)</td><td>1,463</td></tr></table>

(1) The 2021 and 2020 comparatives have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see Note 4f).

(2) On 1 February 2022, ViiV Healthcare reached agreement with Gilead Sciences, Inc. (Gilead) to settle the global patent infringement litigation relating to the commercialisation of Gilead's Biktarovy concerning ViiV Healthcare's patents relating to dolutegravir, an anti-retroviral medication used, together with other medicines, to treat human immunodeficiency virus (HIV). Under the terms of the global settlement and licensing agreement, Gilead made an upfront payment of $1.25 billion ($922 million) to ViiV Healthcare on 15 February 2022. In addition, Gilead will also pay a 3% royalty on all future US sales of Biktarovy and in respect of the bictegravir component of any other future bictegravir-containing products sold in the US. These royalties will be payable by Gilead to ViiV Healthcare from 1 February 2022 until the expiry of ViiV Healthcare's US Patent No. 8129,385 on 5 October 2027 and will be recorded as Royalty income in the Income Statement.

Fair value remeasurement on equity investments in 2022 included a gain/loss of £229 million from the remeasurement of the Group's retained investment in Haleon plc to fair value at 31 December 2022 from the initial recognition fair value (five-day average share price after the demerger). See details in Note 22.

Disposal of businesses and assets in 2022 includes milestone income and the reversal of provisions no longer required.

Disposal of businesses and assets in 2021 included a net gain on disposal of the rights to the royalty stream for cabozantinib and a net gain on disposal of the cephalosporin antibiotic brands to Sandoz.

Disposal of businesses and assets in 2020 included a net profit on disposal of the Horlicks and other Consumer Healthcare nutritional brands and two subsidiaries in India and Bangladesh of £2,815 million, which reflected reversal of £240 million of embedded derivative gains on the value of the shares taken in prior years. This was partly offset by the related £476 million loss on the shares in Hindustan Unilever Limited, including fair value remeasurement losses between their acquisition as consideration for the divestment of GSK Consumer Healthcare Limited in India and their subsequent disposal. Other operating income also included an increase in profit and milestone income from a number of asset disposals.

Fair value remeasurements on contingent consideration recognised as business combinations included £1,431 million related to the acquisition of the former Shionogi-ViiV Healthcare joint venture and £193 million payable to Novartis related to the Vaccines acquisition, together with fair value movements on related hedging contracts.



## 8. Operating profit

<table><tr><td>The following items have been included in operating profit:</td><td>2022</td><td>2021 \( ^{(1)} \)</td><td>2020 \( ^{(1)} \)</td></tr><tr><td>Employee costs (Note 9)</td><td>7,693</td><td>7,680</td><td>8,555</td></tr><tr><td>Advertising</td><td>735</td><td>433</td><td>361</td></tr><tr><td>Distribution costs</td><td>192</td><td>169</td><td>176</td></tr><tr><td>Depreciation of property, plant and equipment</td><td>885</td><td>855</td><td>822</td></tr><tr><td>Impairment of property, plant and equipment, net of reversals</td><td>70</td><td>87</td><td>424</td></tr><tr><td>Depreciation of right of use assets</td><td>176</td><td>179</td><td>182</td></tr><tr><td>Impairment of right of use assets</td><td>40</td><td>5</td><td>2</td></tr><tr><td>Amortisation of intangible assets</td><td>1,086</td><td>1,088</td><td>1,046</td></tr><tr><td>Impairment of intangible assets, net of reversals</td><td>365</td><td>435</td><td>230</td></tr><tr><td>Impairment of intangible assets held for sale, net of reversals</td><td>-</td><td>1</td><td>-</td></tr><tr><td>Impairment of goodwill allocated to a disposal group, net of reversals</td><td>-</td><td>-</td><td>2</td></tr><tr><td>Net foreign exchange (gains)/losses</td><td>11</td><td>(4)</td><td>99</td></tr><tr><td>Inventories:</td><td></td><td></td><td></td></tr><tr><td>Cost of inventories included in cost of sales</td><td>6,137</td><td>5,885</td><td>5,934</td></tr><tr><td>Write-down of inventories</td><td>687</td><td>800</td><td>607</td></tr><tr><td>Reversal of prior year write-down of inventories</td><td>(483)</td><td>(325)</td><td>(250)</td></tr><tr><td>Short-term lease charge</td><td>6</td><td>7</td><td>11</td></tr><tr><td>Low-value lease charge</td><td>2</td><td>3</td><td>5</td></tr><tr><td>Variable lease payments</td><td>9</td><td>10</td><td>11</td></tr><tr><td>Fees payable to the company&#x27;s auditor and its associates in relation to the Group (see below)</td><td>269</td><td>317</td><td>299</td></tr></table>

The reversals of prior year write-downs of inventories principally arise from the reassessment of usage or demand expectations prior to inventory expiration.

Net foreign exchange (gains)/losses include a net loss of £2 million (2021: £35 million gain; 2020: £36 million loss) arising from the recycling of exchange on liquidation or disposal of overseas subsidiaries. The recycling of exchange on disposal of overseas associates of a loss of £nil (2021: £10 million) is reported through loss on disposal of interest in associates. The recycling of exchange on disposal of overseas subsidiaries does not include recycling of exchange on disposal of Consumer Healthcare subsidiaries as this is reported as Profit after taxation on demerger of discontinued operations.

Included within operating profit are Major restructuring charges of £321 million (2021: £424 million; 2020: £1,178 million), see Note 10, 'Major restructuring costs'.

<table><tr><td>Fees payable to the company&#x27;s auditor and its associates:</td><td>2022</td><td>2021</td><td>2020</td></tr><tr><td>Audit of parent company and consolidated financial statements including attestation under s.404 of Sarbanes-Oxley Act 2002</td><td>£m</td><td>£m</td><td>£m</td></tr><tr><td>Audit of the company&#x27;s subsidiaries</td><td>9.7</td><td>14.5</td><td>14.5</td></tr><tr><td>Total audit services</td><td>20.6</td><td>27.7</td><td>28.3</td></tr><tr><td>Audit-related and other assurance services</td><td>6.3</td><td>4.0</td><td>1.6</td></tr><tr><td>Total audit services, audit-related and other assurance services</td><td>26.9</td><td>31.7</td><td>29.9</td></tr></table>

The other assurance services provided by the auditor related to agreed upon procedures and other assurance services outside of statutory audit requirements. In addition to the above, fees paid to the auditor in respect of the GSK pension schemes were:

<table><tr><td></td><td>2022</td><td>2021</td><td>2020</td></tr><tr><td>Audit</td><td>£m</td><td>£m</td><td>£m</td></tr><tr><td></td><td>0.2</td><td>0.2</td><td>0.2</td></tr></table>

There were immaterial fees of £0.1 million paid in 2022 (versus 2021: £nil; 2020 £0.2 million) to other auditors in respect of audits of certain of the company’s subsidiaries.

Audit related and other assurance services include £4.4 million (2021: £2.4 million) due to reporting accountant work performed in preparation for the Consumer Healthcare demerger.



## 9. Employee costs

<table><tr><td></td><td>2022
£m</td><td>2021 \( ^{①} \) 
£m</td><td>2020 \( ^{①} \) 
£m</td></tr><tr><td>Wages and salaries</td><td>6,110</td><td>5,858</td><td>6,464</td></tr><tr><td>Social security costs</td><td>763</td><td>793</td><td>775</td></tr><tr><td>Pension and other post-employment costs, including augmentations (Note 3i)</td><td>369</td><td>415</td><td>466</td></tr><tr><td>Cost of share-based incentive plans</td><td>314</td><td>345</td><td>330</td></tr><tr><td>Severance and other costs from integration and restructuring activities</td><td>137</td><td>269</td><td>520</td></tr><tr><td></td><td>7,693</td><td>7,680</td><td>8,555</td></tr></table>

The Group provides benefits to employees, commensurate with local practice in individual countries, including in some markets, healthcare insurance, subsidised car schemes and personal life assurance.

The cost of share-based incentive plans is analysed as follows:

<table><tr><td></td><td>2022
£m</td><td>2021 \( ^{①} \) 
£m</td><td>2020 \( ^{①} \) 
£m</td></tr><tr><td>Share Value Plan</td><td>243</td><td>258</td><td>266</td></tr><tr><td>Performance Share Plan</td><td>55</td><td>51</td><td>56</td></tr><tr><td>Share option plans</td><td>4</td><td>5</td><td>4</td></tr><tr><td>Cash settled and other plans</td><td>12</td><td>31</td><td>4</td></tr><tr><td></td><td>314</td><td>345</td><td>330</td></tr></table>

The average number of persons employed by the Group (including Directors) during the year:

<table><tr><td></td><td>2022
Number</td><td>2021 \( ^{①} \) 
Number</td><td>2020 \( ^{①} \) 
Number</td></tr><tr><td>Manufacturing</td><td>22,946</td><td>23,562</td><td>24,536</td></tr><tr><td>Selling, general and administration</td><td>34,642</td><td>36,909</td><td>37,977</td></tr><tr><td>Research and development</td><td>11,542</td><td>10,874</td><td>10,744</td></tr><tr><td>Total Continuing Operations</td><td>69,130</td><td>71,345</td><td>73,257</td></tr><tr><td>Discontinued Operations</td><td>21,292</td><td>20,616</td><td>22,628</td></tr><tr><td>Total</td><td>90,422</td><td>91,961</td><td>95,885</td></tr></table>

Note: Consumer Healthcare divested on 18 July 2022 is shown as Discontinued Operations in the above table.

The average monthly number of Group employees excludes temporary and contract staff. The numbers of Group employees at the end of each financial year are given in the financial record on page 277.

The compensation of the Directors and senior management (members of the GLT) in aggregate, was as follows:

<table><tr><td></td><td>2022
£m</td><td>2021 \( ^{①} \) 
£m</td><td>2020 \( ^{①} \) 
£m</td></tr><tr><td>Wages and salaries</td><td>31</td><td>27</td><td>21</td></tr><tr><td>Social security costs</td><td>5</td><td>3</td><td>4</td></tr><tr><td>Pension and other post-employment costs</td><td>2</td><td>3</td><td>3</td></tr><tr><td>Cost of share-based incentive plans</td><td>28</td><td>27</td><td>23</td></tr><tr><td></td><td>66</td><td>60</td><td>51</td></tr></table>

Further information on the remuneration of the Directors is given in the sections of the Annual Report on remuneration labelled as audited within pages 133 to 164.



## 10. Major restructuring costs

Within the Pharmaceuticals sector, the highly regulated manufacturing operations and supply chains and long lifecycle of the business mean that restructuring programmes, particularly those that involve the rationalisation or closure of manufacturing or R&D sites, are likely to take several years to complete.

Major restructuring costs are those related to specific Board-approved Major restructuring programmes, including integration costs following material acquisitions, which are structural and are of a significant scale where the costs of individual or related projects exceed £25 million.

In January 2020, the Board approved a Separation Preparation programme to prepare for the separation of GSK into two companies. Materially all of the Separation Preparation restructuring programme has been included as part of continuing operations. The legacy Consumer Healthcare Joint Venture integration programme is now included as part of discontinued operations.

After the acquisition of Sierra Oncology (July 2022) and Affinivax (August 2022), the Board approved a Major restructuring programme for the Integration of significant acquisitions designed to integrate and achieve synergies.

The total restructuring costs of £321 million in 2022 were incurred in the following areas:

– Restructuring costs to prepare for separation of GSK into two companies

– Continued transformation of central functions, including GSK technology platforms and interfaces, to deliver greater digital synergies, simplification of applications and staff reductions

– The integration of acquisitions.

The analysis of the costs charged to operating profit from continuing operations under these programmes was as follows:

<table><tr><td></td><td>2022
£m</td><td>2021(1)
£m</td><td>2020(1)
£m</td></tr><tr><td>Increase in provision for Major restructuring programmes (see Note 32)</td><td>138</td><td>321</td><td>606</td></tr><tr><td>Amount of provision reversed unused (see Note 32)</td><td>(111)</td><td>(140)</td><td>(71)</td></tr><tr><td>Impairment losses recognised</td><td>122</td><td>14</td><td>347</td></tr><tr><td>Other non-cash charges/(credit)</td><td>(7)</td><td>25</td><td>62</td></tr><tr><td>Other cash costs</td><td>179</td><td>204</td><td>234</td></tr><tr><td></td><td>321</td><td>424</td><td>1,178</td></tr></table>

Provision reversals of £111 million (2021 \( ^{(1)} $ : £140 million; 2020 \( ^{(1)} $ : £71 million) reflected provision releases mainly related to the Separation Preparation programme. Asset impairments of £122 million and other non-cash credit of £7 million principally comprised fixed asset write-downs of manufacturing facilities and accelerated depreciation where asset lives have been shortened in the supply chain manufacturing network as a result of the Major restructuring programmes, offset by profit on disposals. All other charges have been or will be settled in cash and include site closure costs, consultancy and project management costs.

The analysis of Major restructuring charges from continuing operations by programme was as follows:

<table><tr><td rowspan="2"></td><td colspan="3">2022</td></tr><tr><td>Cash
£m</td><td>Non-cash
£m</td><td>Total
£m</td></tr><tr><td>Separation Preparation programme</td><td>177</td><td>110</td><td>287</td></tr><tr><td>Significant acquisitions</td><td>20</td><td>-</td><td>20</td></tr><tr><td>Legacy programmes</td><td>9</td><td>5</td><td>14</td></tr><tr><td></td><td>206</td><td>115</td><td>321</td></tr><tr><td></td><td></td><td></td><td>2021(1)</td></tr><tr><td></td><td>Cash
£m</td><td>Non-cash
£m</td><td>Total
£m</td></tr><tr><td>Separation Preparation programme</td><td>353</td><td>59</td><td>412</td></tr><tr><td>Legacy programmes</td><td>32</td><td>(20)</td><td>12</td></tr><tr><td></td><td>385</td><td>39</td><td>424</td></tr></table>



## Notes to the financial statements continued

## 10. Major restructuring costs continued

The analysis of Major restructuring charges from continuing operations by income statement line was as follows:

<table><tr><td></td><td>2022
£m</td><td>2021(1)
£m</td><td>2020(1)
£m</td></tr><tr><td>Cost of sales</td><td>102</td><td>102</td><td>585</td></tr><tr><td>Selling, general and administration</td><td>180</td><td>277</td><td>395</td></tr><tr><td>Research and development</td><td>39</td><td>45</td><td>198</td></tr><tr><td></td><td>321</td><td>424</td><td>1,178</td></tr></table>

## 11. Finance income

<table><tr><td></td><td>2022
£m</td><td>2021(1)
£m</td><td>2020(1)
£m</td></tr><tr><td>Finance income arising from:</td><td></td><td></td><td></td></tr><tr><td>Financial assets measured at amortised cost</td><td>31</td><td>11</td><td>17</td></tr><tr><td>Financial assets measured at fair value through profit or loss</td><td>31</td><td>2</td><td>9</td></tr><tr><td>Net gains arising from the forward element of forward contracts in net investment hedge relationships</td><td>12</td><td>-</td><td>5</td></tr><tr><td>Other finance income</td><td>2</td><td>1</td><td>1</td></tr><tr><td></td><td>76</td><td>14</td><td>32</td></tr></table>

## 12. Finance expense

<table><tr><td></td><td>2022
£m</td><td>2021(1)
£m</td><td>2020(1)
£m</td></tr><tr><td>Finance expense arising on:</td><td></td><td></td><td></td></tr><tr><td>Financial liabilities at amortised cost</td><td>(789)</td><td>(735)</td><td>(811)</td></tr><tr><td>Net losses arising from:</td><td></td><td></td><td></td></tr><tr><td>Financial instruments mandatorily measured at fair value through profit or loss</td><td>743</td><td>(565)</td><td>382</td></tr><tr><td>Retranslation of loans</td><td>(761)</td><td>565</td><td>(384)</td></tr><tr><td>Reclassification of hedges from other comprehensive income</td><td>(2)</td><td>(2)</td><td>(2)</td></tr><tr><td>Unwinding of discounts on provisions</td><td>(7)</td><td>(2)</td><td>(3)</td></tr><tr><td>Finance expense arising on lease liabilities</td><td>(30)</td><td>(27)</td><td>(33)</td></tr><tr><td>Other finance expense</td><td>(33)</td><td>(3)</td><td>(23)</td></tr><tr><td></td><td>(879)</td><td>(769)</td><td>(874)</td></tr></table>



## 13. Associates and joint ventures

The Group’s share of after-tax profits and losses of associates and joint ventures is set out below:

<table><tr><td></td><td>2022</td><td>2021 \( ^{(1)} \)</td><td>2020 \( ^{(1)} \)</td></tr><tr><td></td><td>£m</td><td>£m</td><td>£m</td></tr><tr><td>Share of after-tax profits of associates</td><td>1</td><td>36</td><td>33</td></tr><tr><td>Share of after-tax losses of joint ventures</td><td>(3)</td><td>(3)</td><td>—</td></tr><tr><td></td><td>(2)</td><td>33</td><td>33</td></tr></table>

(1) 2021 and 2020 comparatives have not been restated, as the demerged Consumer Healthcare business contained no associates or joint ventures.

Following the disposal of Innoviva, Inc in May 2021 (see details in Note 4I), at 31 December 2022 and 31 December 2021 the Group held no significant individual associates. At 31 December 2020, the Group held one significant associate, Innoviva, Inc.

Summarised income statement information in respect of Innoviva until May 2021 is set out below. The Group’s 2021 share of after-tax profits of associates and other comprehensive income included a profit of £33 million and other comprehensive income of £nil in respect of Innoviva.

The results of Innoviva included in the summarised income statement information below represent the estimated earnings of Innoviva in the relevant periods, based on publicly available information at the balance sheet date. Figures for 2021 include share of Innoviva's turnover, profit and total comprehensive income until the date of the disposal.

<table><tr><td></td><td>2021</td><td>2020</td></tr><tr><td></td><td>£m</td><td>£m</td></tr><tr><td>Turnover</td><td>108</td><td>253</td></tr><tr><td>Profit after taxation</td><td>106</td><td>174</td></tr><tr><td>Total comprehensive income</td><td>106</td><td>174</td></tr></table>

Aggregated financial information in respect of GSK’s share of other associated undertakings and joint ventures is set out below:

<table><tr><td></td><td>2022</td><td>2021</td><td>2020</td></tr><tr><td></td><td>£m</td><td>£m</td><td>£m</td></tr><tr><td>Share of after-tax losses</td><td>(2)</td><td>—</td><td>(8)</td></tr><tr><td>Share of other comprehensive income/(expense)</td><td>(9)</td><td>28</td><td>53</td></tr><tr><td>Share of total comprehensive income/(expense)</td><td>(11)</td><td>28</td><td>45</td></tr></table>

The Group’s sales to associates and joint ventures were £nil in 2022 (2021: £nil; 2020: £nil).

Please refer to the Balance sheet information on associates and joint ventures in Note 21.



## 14. Taxation

The Group’s tax charge is the sum of the total current and deferred tax expense.

<table><tr><td>Taxation charge based on profits for the year</td><td>2022£m</td><td>2021(1)£m</td><td>2020(1)£m</td></tr><tr><td>UK current year charge</td><td>200</td><td>119</td><td>(45)</td></tr><tr><td>Rest of World current year charge</td><td>1,351</td><td>593</td><td>745</td></tr><tr><td>Charge/(credit) in respect of prior periods</td><td>(60)</td><td>219</td><td>11</td></tr><tr><td>Current taxation</td><td>1,491</td><td>931</td><td>711</td></tr><tr><td>Deferred taxation</td><td>(784)</td><td>(848)</td><td>(644)</td></tr><tr><td></td><td>707</td><td>83</td><td>67</td></tr></table>

In 2022, GSK made corporate income tax payments globally of £1.5 billion for continuing and discontinued operations, of which £48 million was UK corporation tax paid to HMRC. These amounts are for corporate income tax only, and do not include the various other business taxes borne by GSK each year.

The deferred tax credits in each period reflect current year losses where offset against taxable profits in future periods is probable and the release of deferred tax liabilities. The latter relates primarily to the unwind of deferred tax liabilities on intangible assets. The deferred tax credit in 2021 also reflected the impact of the remeasurement of deferred tax assets and liabilities following enactment of the increase in the headline rate of UK corporation tax from 19% to 25%.

The following table reconciles the tax charge calculated at the UK statutory rate on the Group profit before tax with the actual tax charge for the year.

<table><tr><td>Reconciliation of taxation on Group profits</td><td>2022£m</td><td>2022%</td><td>2021(1)£m</td><td>2021%</td><td>2020(1)£m</td><td>2020%</td></tr><tr><td>Profit before tax</td><td>5,628</td><td></td><td>3,599</td><td></td><td>5,170</td><td></td></tr><tr><td>UK statutory rate of taxation</td><td>1,069</td><td>19.0</td><td>685</td><td>19.0</td><td>984</td><td>19.0</td></tr><tr><td>Differences in overseas taxation rates</td><td>318</td><td>5.6</td><td>302</td><td>8.4</td><td>363</td><td>70</td></tr><tr><td>Benefit of intellectual property incentives</td><td>(600)</td><td>(10.7)</td><td>(382)</td><td>(10.6)</td><td>(516)</td><td>(99)</td></tr><tr><td>R&amp;D credits</td><td>(119)</td><td>(2.1)</td><td>(100)</td><td>(2.8)</td><td>(103)</td><td>(2.0)</td></tr><tr><td>Permanent differences on disposals, acquisitions and transfers</td><td>275</td><td>4.9</td><td>(3)</td><td>(0.1)</td><td>(316)</td><td>(6.1)</td></tr><tr><td>Other permanent differences</td><td>82</td><td>1.5</td><td>(4)</td><td>(0.1)</td><td>90</td><td>1.7</td></tr><tr><td>Re-assessments of prior year current tax estimates</td><td>(60)</td><td>(1.1)</td><td>219</td><td>6.1</td><td>11</td><td>0.2</td></tr><tr><td>Re-assessments of prior year deferred tax estimates</td><td>(233)</td><td>(4.1)</td><td>(281)</td><td>(7.8)</td><td>(283)</td><td>(5.5)</td></tr><tr><td>Changes in Tax Rates</td><td>(25)</td><td>(0.4)</td><td>(353)</td><td>(9.8)</td><td>(163)</td><td>(3.1)</td></tr><tr><td>Tax charge/tax rate</td><td>707</td><td>12.6</td><td>83</td><td>2.3</td><td>67</td><td>12.9</td></tr></table>

As a global biopharmaceutical company, we have a substantial business and employment presence in many countries around the world. The impact of differences in overseas taxation rates arose from profits being earned in countries with tax rates higher than the UK statutory rate, the most significant of which in 2022 were the US, Belgium, Germany and Japan. This adverse impact was offset by the benefit of intellectual property incentives such as the UK Patent Box and Belgian Innovation Income Deduction regimes, which provide a reduced rate of corporation tax on profits earned from qualifying patents. We claim these incentives in the manner intended by the relevant statutory or regulatory framework.

In 2021, ‘Changes in tax rates’ included credits in relation to the enactment of the increase in the headline rate of UK corporate income tax from 19% to 25% (effective 2023). In 2020, ‘Changes in tax rates’ included credits in relation to the UK, where a reduction in the corporate income tax rate from 19% to 17% was cancelled, and India, where the tax treatment of dividends changed with effect from 1 April 2020.

Permanent differences on disposals, acquisitions and transfers in 2022 includes tax on internal restructuring to simplify the group structure. The tax credit in 2020 reflected the tax impact of the disposal of Horlicks and other Consumer Healthcare brands to, and subsequent disposal of shares received in, Hindustan Unilever.

The Group’s 2022 tax rate has also been influenced by updates to estimates of prior period tax liabilities following closure of open issues with tax authorities in various jurisdictions.



## Notes to the financial statements continued

## 14. Taxation continued

Future tax charges, and therefore our effective tax rate, may be affected by factors such as acquisitions, disposals, restructurings, the location of research and development activity, tax regime reforms and resolution of open matters as we continue to bring our tax affairs up to date around the world.

The UK Government has confirmed that the Spring Finance Bill 2023 will include legislation introducing a 15% global minimum corporate income tax rate, to have effect from 2024 in line with the OECD's Pillar Two model framework. The detail of the measures and how they are to be accounted for is still being finalised and so it is not possible to accurately quantify the impact for GSK at this stage.

<table><tr><td>Tax on items charged to equity and statement of comprehensive income</td><td>2022
£m</td><td>2021(1)
£m</td><td>2020(1)
£m</td></tr><tr><td>Current taxation</td><td></td><td></td><td></td></tr><tr><td>Share-based payments</td><td>(3)</td><td>-</td><td>(14)</td></tr><tr><td>Defined benefit plans</td><td>-</td><td>-</td><td>(4)</td></tr><tr><td>Fair value movements on cash flow hedges</td><td>-</td><td>5</td><td>12</td></tr><tr><td>Fair value movements on equity investments</td><td>12</td><td>36</td><td>89</td></tr><tr><td></td><td>9</td><td>41</td><td>83</td></tr><tr><td>Deferred taxation</td><td></td><td></td><td></td></tr><tr><td>Share-based payments</td><td>11</td><td>(11)</td><td>18</td></tr><tr><td>Defined benefit plans</td><td>(211)</td><td>223</td><td>(51)</td></tr><tr><td>Fair value movements on cash flow hedges</td><td>(9)</td><td>3</td><td>6</td></tr><tr><td>Fair value movements on equity investments</td><td>(68)</td><td>(167)</td><td>131</td></tr><tr><td></td><td>(277)</td><td>48</td><td>104</td></tr><tr><td>Total credit to equity and statement of comprehensive income</td><td>(268)</td><td>89</td><td>187</td></tr></table>

(1) The 2021 and 2020 comparatives have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see Note 4I).

All of the above items have been charged to the statement of comprehensive income except for tax on share-based payments.

## Issues relating to taxation

The integrated nature of the Group’s worldwide operations involves significant investment in research and strategic manufacture at a limited number of locations, with consequential cross-border supply routes into numerous end-markets. In line with current OECD guidelines, we base our transfer pricing policy on the arm’s length principle and support our transfer prices with economic analysis and reports. However, different tax authorities may seek to attribute further profit to activities being undertaken in their jurisdiction potentially resulting in double taxation. The Group also has open items in several jurisdictions concerning such matters as the deductibility of particular expenses and the tax treatment of certain business transactions. GSK applies a risk based approach to determine the transactions most likely to be subject to challenge and the probability that the Group would be able to obtain compensatory adjustments under international tax treaties.

The calculation of the Group’s total tax charge therefore necessarily involves a degree of estimation and judgement in respect of certain items whose tax treatment cannot be finally determined until resolution has been reached with the relevant tax authority or, as appropriate, through a formal legal process. At 31 December 2022 the Group had recognised provisions of £551 million in respect of such uncertain tax positions (2021: £858 million). The net decrease in recognised provisions during 2022 was driven by the reassessment of estimates, the agreement of a number of open issues with tax authorities in various jurisdictions and amounts related to discontinued operations. Whilst the ultimate liability for such matters may vary from the amounts provided and is dependent upon the outcome of agreements with the relevant tax authorities, or litigation where appropriate, the Group continues to consider that it has made appropriate provision for periods which are open and not yet agreed by the tax authorities.

A provision for deferred tax liabilities of £157 million as at 31 December 2022 (2021: £204 million) has been made in respect of taxation that would be payable on the remittance of profits by certain overseas subsidiaries. Whilst the aggregate amount of unremitted profits at the balance sheet date was approximately £16 billion (2021: £15 billion), the majority of these unremitted profits would not be subject to tax (including withholding tax) on repatriation, as UK legislation relating to company distributions provides for exemption from tax for most overseas profits, subject to certain exceptions. Deferred tax is not provided on temporary differences of £660 million (2021: £831 million) arising on unremitted profits as management has the ability to control any future reversal and does not consider such a reversal to be probable.



## Notes to the financial statements continued

## 14. Taxation continued

## Movement in deferred tax assets and liabilities

<table><tr><td></td><td>Accelerated capital allowances £m</td><td>Intangible assets £m</td><td>Contingent consideration £m</td><td>Intra-Group profit £m</td><td>Pensions &amp; other post employment benefits £m</td><td>Tax losses £m</td><td>Share option and award schemes £m</td><td>Other net temporary differences £m</td><td>Total £m</td></tr><tr><td>At 1 January 2021</td><td>(296)</td><td>(3,982)</td><td>843</td><td>1,024</td><td>874</td><td>1,060</td><td>60</td><td>1,104</td><td>687</td></tr><tr><td>Exchange adjustments</td><td>17</td><td>(41)</td><td>-</td><td>6</td><td>(17)</td><td>(1)</td><td>-</td><td>-</td><td>(36)</td></tr><tr><td>Credit/(charge) to income statement</td><td>65</td><td>312</td><td>7</td><td>(31)</td><td>6</td><td>391</td><td>20</td><td>232</td><td>1,002</td></tr><tr><td>Credit/(charge) to statement of comprehensive income</td><td>-</td><td>-</td><td>-</td><td>-</td><td>(223)</td><td>-</td><td>11</td><td>164</td><td>(48)</td></tr><tr><td>Acquisitions/Disposals</td><td>3</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>(4)</td><td>(1)</td></tr><tr><td>R&amp;D credits utilisation</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>58</td><td>58</td></tr><tr><td>At 31 December 2021</td><td>(211)</td><td>(3,711)</td><td>850</td><td>999</td><td>640</td><td>1,450</td><td>91</td><td>1,554</td><td>1,662</td></tr><tr><td>Exchange adjustments</td><td>(29)</td><td>(264)</td><td>-</td><td>(40)</td><td>64</td><td>6</td><td>1</td><td>160</td><td>(102)</td></tr><tr><td>Credit/(charge) to income statement</td><td>122</td><td>126</td><td>142</td><td>258</td><td>(32)</td><td>104</td><td>(22)</td><td>190</td><td>888</td></tr><tr><td>Credit/(charge) to statement of comprehensive income</td><td>-</td><td>-</td><td>-</td><td>-</td><td>182</td><td>42</td><td>(11)</td><td>(12)</td><td>201</td></tr><tr><td>Acquisitions/Disposals</td><td>(1)</td><td>(637)</td><td>-</td><td>-</td><td>-</td><td>67</td><td>-</td><td>76</td><td>(495)</td></tr><tr><td>R&amp;D credits utilisation</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>(76)</td><td>(76)</td></tr><tr><td>Transfer of assets held for sale/ distribution</td><td>62</td><td>3,667</td><td>-</td><td>(118)</td><td>(60)</td><td>(8)</td><td>(2)</td><td>(250)</td><td>3,291</td></tr><tr><td>At 31 December 2022</td><td>(57)</td><td>(819)</td><td>992</td><td>1,099</td><td>794</td><td>1,661</td><td>57</td><td>1,642</td><td>5,369</td></tr></table>

Deferred tax liabilities in relation to intangible assets predominately relate to temporary differences arising as a result of historic business combinations.

The Group continues to recognise deferred tax assets on future obligations in respect of contingent consideration amounts payable to minority shareholders. These payments are tax deductible at the point in time at which payment is made.

A deferred tax asset is recognised on intra-Group profits arising on inter-company inventory which are eliminated within the consolidated accounts. As intra-Group profits are not eliminated from the individual entities' tax returns a temporary difference arises that will reverse at the point in time inventory is sold externally.

The deferred tax asset recognised on tax losses of £1,661 million (2021: £1,450 million) relates to trading losses. Such deferred tax assets are recognised where it is probable that future taxable profit will be available to utilise losses, as supported by long-range product level forecasts. Current forecasts indicate the assets will be utilised by around 2030. Other net temporary differences included accrued expenses for which a tax deduction is only available on a paid basis.

Deferred tax assets and liabilities are recognised on the balance sheet as follows:

<table><tr><td></td><td>2022 £m</td><td>2021 £m</td></tr><tr><td>Deferred tax assets</td><td>5,658</td><td>5,218</td></tr><tr><td>Deferred tax liabilities</td><td>(289)</td><td>(3,556)</td></tr><tr><td></td><td>5,369</td><td>1,662</td></tr></table>

<table><tr><td rowspan="2">Unrecognised tax losses</td><td colspan="3">2022</td><td colspan="2">2021</td></tr><tr><td>Tax losses £m</td><td>Unrecognised deferred tax asset £m</td><td>Tax losses £m</td><td>Unrecognised deferred tax asset £m</td><td></td></tr><tr><td>Trading losses expiring:</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Within 10 years</td><td>967</td><td>175</td><td>1,068</td><td>198</td><td></td></tr><tr><td>More than 10 years</td><td>44</td><td>13</td><td>390</td><td>62</td><td></td></tr><tr><td>Available indefinitely</td><td>192</td><td>41</td><td>200</td><td>43</td><td></td></tr><tr><td>At 31 December</td><td>1,203</td><td>229</td><td>1,658</td><td>303</td><td></td></tr><tr><td>Capital losses expiring:</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Available indefinitely</td><td>2,326</td><td>548</td><td>2,356</td><td>557</td><td></td></tr><tr><td>At 31 December</td><td>2,326</td><td>548</td><td>2,356</td><td>557</td><td></td><td rowspan="2"></td></tr></table>

Deferred tax assets are only recognised where it is probable that future taxable profit will be available to utilise losses.



## 15. Earnings per share

<table><tr><td></td><td>2022pence</td><td>2021 \( ^{(1)} \)  pence</td><td>2020 \( ^{(1)} \)  pence</td></tr><tr><td>Basic earnings per share from continuing operations</td><td>110.8</td><td>82.9</td><td>122.4</td></tr><tr><td>Basic earnings per share from discontinued operations</td><td>260.6</td><td>26.7</td><td>22.0</td></tr><tr><td>Total basic earnings per share</td><td>371.4</td><td>109.6</td><td>144.4</td></tr><tr><td>Diluted earnings per share from continuing operations</td><td>109.2</td><td>81.8</td><td>120.9</td></tr><tr><td>Diluted earnings per share from discontinued operations</td><td>257.0</td><td>26.4</td><td>21.7</td></tr><tr><td>Total diluted earnings per share</td><td>366.2</td><td>108.2</td><td>142.6</td></tr></table>

(1) The 2021 and 2020 comparatives have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see Note 4I) and/or the impact of Share Consolidation (see Note 37).

Basic earnings per share has been calculated by dividing the profit attributable to shareholders by the weighted average number of shares in issue during the period after deducting shares held by the ESOP Trusts and Treasury shares. The trustees have waived their rights to cash dividends on the GSK shares held by the ESOP Trusts.

Diluted earnings per share has been calculated after adjusting the weighted average number of shares used in the basic calculation to assume the conversion of all potentially dilutive shares. A potentially dilutive share forms part of the employee share schemes where its exercise price is below the average market price of GSK shares during the period and any performance conditions attaching to the scheme have been met at the balance sheet date.

The numbers of shares used in calculating basic and diluted earnings per share are reconciled below.

<table><tr><td></td><td>2022</td><td>2021 \( ^{(2)} \)</td><td>2020 \( ^{(2)} \)</td></tr><tr><td>Weighted average number of shares in issue</td><td></td><td></td><td></td></tr><tr><td>Basic</td><td>4,026</td><td>4,003</td><td>3,981</td></tr><tr><td>Dilution for share options and awards</td><td>58</td><td>49</td><td>49</td></tr><tr><td>Diluted</td><td>4,084</td><td>4,052</td><td>4,030</td></tr></table>

(2) Restated to reflect the impact share consolidation (see Note 37).

## 16. Dividends

<table><tr><td rowspan="2"></td><td colspan="4">2022</td><td colspan="4">2021</td><td colspan="2">2020</td></tr><tr><td>Paid/payable</td><td>Dividend per share (pence) \( ^{(3)} \)</td><td>Total dividend £m</td><td>Paid</td><td>Dividend per share (pence) \( ^{(3)} \)</td><td>Total £m</td><td>Paid</td><td>Dividend per share (pence) \( ^{(2)} \)</td><td>Total £m</td><td>Paid</td></tr><tr><td>First interim</td><td>1 July 2022</td><td>17.50</td><td>704</td><td>8 July 2021</td><td>23.75</td><td>951</td><td>9 July 2020</td><td>23.75</td><td>946</td><td></td></tr><tr><td>Second interim</td><td>6 October 2022</td><td>16.25</td><td>654</td><td>7 October 2021</td><td>23.75</td><td>951</td><td>8 October 2020</td><td>23.75</td><td>946</td><td></td></tr><tr><td>Third interim</td><td>12 January 2023</td><td>13.75</td><td>555</td><td>13 January 2022</td><td>23.75</td><td>952</td><td>14 January 2021</td><td>23.75</td><td>946</td><td></td></tr><tr><td>Fourth interim</td><td>13 April 2023</td><td>13.75</td><td>555</td><td>7 April 2022</td><td>28.75</td><td>1,157 \( ^{*} \)</td><td>8 April 2021</td><td>28.75</td><td>1,151</td><td></td></tr><tr><td>Total</td><td></td><td>61.25</td><td>2,468</td><td></td><td>100</td><td>4,011</td><td></td><td>100</td><td>3,989</td><td></td></tr></table>

* The estimate for the fourth interim dividend for 2021 disclosed in the 2021 annual report was £1.52 million, £5 million less than the dividend that was ultimately paid.
(3) Dividends per share were retrospectively adjusted to reflect the Share Consolidation in all the periods presented. See details in Note 37.

Under IFRS, interim dividends are only recognised in the financial statements when paid and not when declared. GSK normally pays a dividend two quarters after the quarter to which it relates and one quarter after it is declared. The 2022 financial statements recognise those dividends paid in 2022, namely the third and fourth interim dividends for 2021, and the first and second interim dividends for 2022.

The demerger of the Consumer Healthcare business was effected by GSK declaring an interim dividend in specie of Haleon plc shares. The fair value of the distribution was £15,526 million.

The amounts recognised in each year were as follows:

<table><tr><td></td><td>2022</td><td>2021</td><td>2020</td></tr><tr><td>Cash dividends to shareholders</td><td>3,467</td><td>3,999</td><td>3,977</td></tr><tr><td>Dividends in specie to shareholders in Haleon plc shares (Note 4I)</td><td>15,526</td><td>—</td><td>—</td></tr><tr><td></td><td>18,993</td><td>3,999</td><td>3,977</td></tr></table>



## 17. Property, plant and equipment

<table><tr><td></td><td>Land and buildings £m</td><td>Plant, equipment and vehicles £m</td><td>Assets in construction £m</td><td>Total £m</td></tr><tr><td>Cost at 1 January 2021</td><td>7488</td><td>12105</td><td>1890</td><td>21483</td></tr><tr><td>Exchange adjustments</td><td>(214)</td><td>(315)</td><td>(47)</td><td>(576)</td></tr><tr><td>Other additions</td><td>16</td><td>98</td><td>1091</td><td>1205</td></tr><tr><td>Capitalised borrowing costs</td><td>-</td><td>-</td><td>16</td><td>16</td></tr><tr><td>Disposals and write-offs</td><td>(217)</td><td>(940)</td><td>(17)</td><td>(1174)</td></tr><tr><td>Reclassifications</td><td>202</td><td>906</td><td>(1182)</td><td>(74)</td></tr><tr><td>Transfer to assets held for sale/distribution</td><td>(63)</td><td>(38)</td><td>(1)</td><td>(102)</td></tr><tr><td>Cost at 31 December 2021</td><td>7212</td><td>11816</td><td>1750</td><td>20778</td></tr><tr><td>Exchange adjustments</td><td>403</td><td>542</td><td>105</td><td>1050</td></tr><tr><td>Additions through business combinations</td><td>5</td><td>8</td><td>17</td><td>30</td></tr><tr><td>Other additions</td><td>13</td><td>79</td><td>1153</td><td>1245</td></tr><tr><td>Capitalised borrowing costs</td><td>-</td><td>-</td><td>21</td><td>21</td></tr><tr><td>Disposals and write-offs</td><td>(64)</td><td>(222)</td><td>(5)</td><td>(291)</td></tr><tr><td>Reclassifications</td><td>146</td><td>689</td><td>(874)</td><td>(39)</td></tr><tr><td>Transfer to assets held for sale/distribution</td><td>(1067)</td><td>(1959)</td><td>(317)</td><td>(3343)</td></tr><tr><td>Cost at 31 December 2022</td><td>6648</td><td>10953</td><td>1850</td><td>19451</td></tr><tr><td>Depreciation at 1 January 2021</td><td>(3310)</td><td>(7140)</td><td>-</td><td>(10450)</td></tr><tr><td>Exchange adjustments</td><td>100</td><td>191</td><td>-</td><td>291</td></tr><tr><td>Charge for the year</td><td>(267)</td><td>(715)</td><td>-</td><td>(982)</td></tr><tr><td>Disposals and write-offs</td><td>169</td><td>893</td><td>-</td><td>1062</td></tr><tr><td>Transfer to assets held for sale/distribution</td><td>27</td><td>27</td><td>-</td><td>54</td></tr><tr><td>Depreciation at 31 December 2021</td><td>(3281)</td><td>(6744)</td><td>-</td><td>(10205)</td></tr><tr><td>Exchange adjustments</td><td>(191)</td><td>(310)</td><td>-</td><td>(501)</td></tr><tr><td>Charge for the year</td><td>(226)</td><td>(726)</td><td>-</td><td>(952)</td></tr><tr><td>Disposals and write-offs</td><td>47</td><td>181</td><td>-</td><td>228</td></tr><tr><td>Transfer to assets held for sale/distribution</td><td>376</td><td>1130</td><td>-</td><td>1506</td></tr><tr><td>Depreciation at 31 December 2022</td><td>(3275)</td><td>(6469)</td><td>-</td><td>(9744)</td></tr><tr><td>Impairment at 1 January 2021</td><td>(280)</td><td>(551)</td><td>(26)</td><td>(857)</td></tr><tr><td>Exchange adjustments</td><td>7</td><td>10</td><td>3</td><td>20</td></tr><tr><td>Disposals and write-offs</td><td>30</td><td>76</td><td>13</td><td>119</td></tr><tr><td>Impairment losses</td><td>(21)</td><td>(54)</td><td>(37)</td><td>(112)</td></tr><tr><td>Reversal of impairments</td><td>-</td><td>5</td><td>4</td><td>9</td></tr><tr><td>Impairment at 31 December 2021</td><td>(264)</td><td>(514)</td><td>(43)</td><td>(821)</td></tr><tr><td>Exchange adjustments</td><td>(9)</td><td>(14)</td><td>(1)</td><td>(24)</td></tr><tr><td>Disposals and write-offs</td><td>9</td><td>47</td><td>5</td><td>61</td></tr><tr><td>Impairment losses</td><td>(33)</td><td>(45)</td><td>(5)</td><td>(83)</td></tr><tr><td>Reversal of impairments</td><td>-</td><td>9</td><td>-</td><td>9</td></tr><tr><td>Transfer to assets held for sale/distribution</td><td>37</td><td>45</td><td>2</td><td>84</td></tr><tr><td>Impairment at 31 December 2022</td><td>(260)</td><td>(472)</td><td>(42)</td><td>(774)</td></tr><tr><td>Total depreciation and impairment at 31 December 2021</td><td>(3545)</td><td>(7258)</td><td>(43)</td><td>(10846)</td></tr><tr><td>Total depreciation and impairment at 31 December 2022</td><td>(3535)</td><td>(6941)</td><td>(42)</td><td>(10518)</td></tr><tr><td>Net book value at 1 January 2021</td><td>3898</td><td>4414</td><td>1864</td><td>10176</td></tr><tr><td>Net book value at 31 December 2021</td><td>3667</td><td>4558</td><td>1707</td><td>9932</td></tr><tr><td>Net book value at 31 December 2022</td><td>3113</td><td>4012</td><td>1808</td><td>8933</td></tr></table>



## Notes to the financial statements continued

## 17. Property, plant and equipment continued

The weighted average interest rate for capitalised borrowing costs in the year was 4% (2021: 3%). Disposals and write-offs in the year included a number of assets with nil net book value that are no longer in use in the business.

The impairment losses principally arose from decisions to rationalise facilities and were calculated based on fair value less costs of disposal. The fair value less costs of disposal valuation methodology uses significant inputs which are not based on observable market data, and therefore this valuation technique is classified as level 3 of the fair value hierarchy. These calculations determine the net present value of the projected risk-adjusted, post-tax cash flows of the relevant asset or cash generating unit, applying a discount rate of the Group post-tax weighted average cost of capital (WACC) of 7%, adjusted where appropriate for specific segment, country and currency risk.

Assets that continue to be used by the Group are generally assessed as part of their associated cash generating unit on a value in use basis. For value in use calculations, the post-tax cash flows do not include the impact of future uncommitted restructuring plans or improvements. Where an impairment is indicated and a pre-tax cash flow calculation is expected to give a materially different result, the test would be reperformed using pre-tax cash flows and a pre-tax discount rate. The Group WACC is equivalent to a pre-tax discount rate of approximately 9%.

The net impairment losses have been charged to cost of sales: £11 million (2021: £46 million), R&D: £7 million (2021: £3 million) and SG&A: £55 million (2021: £54 million), and included £34 million (2021: £20 million) arising from the Major restructuring programmes.

Reversals of impairment arose from subsequent reviews of the impaired assets where the conditions which gave rise to the original impairments were deemed no longer to apply. All of the reversals have been credited to cost of sales.

During 2022, £39 million (2021: £74 million) of computer software was reclassified from assets in construction to intangible assets on becoming ready for use.

GSK has assessed the qualitative and quantitative impact of climate related risks on asset recoverable amounts and concluded that there are no material impairments.

## 18. Right of use assets

<table><tr><td></td><td>Land and buildings £m</td><td>Plant and equipment £m</td><td>Vehicles £m</td><td>Total £m</td></tr><tr><td>Net book value at 1 January 2021</td><td>699</td><td>18</td><td>113</td><td>830</td></tr><tr><td>Exchange adjustments</td><td>(9)</td><td>(1)</td><td>(5)</td><td>(15)</td></tr><tr><td>Additions</td><td>152</td><td>1</td><td>62</td><td>215</td></tr><tr><td>Depreciation</td><td>(149)</td><td>(5)</td><td>(59)</td><td>(213)</td></tr><tr><td>Disposals</td><td>(53)</td><td>(4)</td><td>(13)</td><td>(70)</td></tr><tr><td>Impairments</td><td>(7)</td><td>-</td><td>-</td><td>(7)</td></tr><tr><td>Net book value at 31 December 2021</td><td>633</td><td>9</td><td>98</td><td>740</td></tr><tr><td>Exchange adjustments</td><td>47</td><td>-</td><td>8</td><td>55</td></tr><tr><td>Additions through business combinations</td><td>53</td><td>-</td><td>-</td><td>53</td></tr><tr><td>Other additions</td><td>140</td><td>2</td><td>91</td><td>233</td></tr><tr><td>Depreciation</td><td>(131)</td><td>(3)</td><td>(58)</td><td>(192)</td></tr><tr><td>Transfer to assets held for sale/distribution</td><td>(115)</td><td>(1)</td><td>(11)</td><td>(127)</td></tr><tr><td>Disposals</td><td>(27)</td><td>(1)</td><td>(8)</td><td>(36)</td></tr><tr><td>Impairments</td><td>(39)</td><td>-</td><td>-</td><td>(39)</td></tr><tr><td>Net book value at 31 December 2022</td><td>561</td><td>6</td><td>120</td><td>687</td></tr></table>

The Group has entered into some commitments for lease contracts that have not yet commenced. See Note 36.

An analysis of lease liabilities is set out in Note 30, 'Net debt'.



## Notes to the financial statements continued

## 19. Goodwill

<table><tr><td></td><td>2022£m</td><td>2021£m</td></tr><tr><td>Cost at 1 January</td><td>10,552</td><td>10,597</td></tr><tr><td>Exchange adjustments</td><td>550</td><td>(55)</td></tr><tr><td>Additions through business combinations (Note 4I)</td><td>1,127</td><td>-</td></tr><tr><td>Other movements</td><td>-</td><td>10</td></tr><tr><td>Transfer to assets held for sale/distribution</td><td>(5,183)</td><td>-</td></tr><tr><td>Cost at 31 December</td><td>7,046</td><td>10,552</td></tr><tr><td>Net book value at 1 January</td><td>10,552</td><td>10,597</td></tr><tr><td>Net book value at 31 December</td><td>7,046</td><td>10,552</td></tr></table>

All Goodwill is allocated to the Group’s segments as follows:

<table><tr><td></td><td>2022</td></tr><tr><td>Commercial operations</td><td>£m</td></tr><tr><td>Total R&amp;D</td><td>6,148</td></tr><tr><td>Net book value at 31 December</td><td>898</td></tr><tr><td></td><td>7,046</td></tr></table>

In 2021, prior to changes in the Group’s segment reporting (Note 6) Goodwill was allocated as follows:

<table><tr><td></td><td>2021</td></tr><tr><td></td><td>£m</td></tr><tr><td>Pharmaceuticals</td><td>4,228</td></tr><tr><td>Vaccines</td><td>1,264</td></tr><tr><td>Consumer Healthcare</td><td>5,060</td></tr><tr><td>Net book value at 31 December</td><td>10,552</td></tr></table>

Goodwill of £5,183 million allocated to Consumer Healthcare was transferred to 'assets held for sale/distribution' prior to the Consumer Healthcare demerger (Note 4I).

The recoverable amounts of the cash generating units are assessed using a fair value less costs of disposal model. Fair value less costs of disposal is calculated using a discounted cash flow approach, with a post-tax discount rate applied to the projected risk-adjusted post-tax cash flows and terminal value.

The discount rate used is based on the Group WACC of 7% (2021: 6.5%), as most cash generating units have integrated operations across large parts of the Group. The discount rate is adjusted where appropriate for specific segment, country and currency risks. The valuation methodology uses significant inputs which are not based on observable market data, therefore this valuation technique is classified as level 3 in the fair value hierarchy.

The R&D segment is evaluated on an arms length pricing model, see assumptions below.

Details relating to the discounted cash flow models used in the impairment tests are as follows:

<table><tr><td>Valuation basis</td><td>Fair value less costs of disposal</td></tr><tr><td rowspan="5">Key assumptions</td><td>Sales growth rates</td></tr><tr><td>Profit margins</td></tr><tr><td>Terminal growth rate</td></tr><tr><td>Discount rate</td></tr><tr><td>Taxation rate</td></tr><tr><td rowspan="5">Determination of assumptions</td><td>Growth rates are internal forecasts based on both internal and external market information.</td></tr><tr><td>Margins reflect past experience, adjusted for expected changes.</td></tr><tr><td>Terminal growth rates based on management&#x27;s estimate of future long-term average growth rates.</td></tr><tr><td>Discount rates based on Group WACC, adjusted where appropriate.</td></tr><tr><td>Taxation rates based on appropriate rates for each jurisdiction.</td></tr><tr><td>Period of specific projected cash flows</td><td>Five years</td></tr><tr><td rowspan="6">Terminal growth rate and discount rate</td><td>Terminal growth rate</td></tr><tr><td>0% p.a.</td></tr><tr><td>7% p.a</td></tr><tr><td>0% p.a.</td></tr><tr><td>7% p.a</td></tr></table>

The terminal growth rate does not exceed the long-term projected growth rates for relevant markets, reflects the impact of future generic competition and take account of new product launches. Goodwill is monitored for impairment at the segmental level and the valuations indicated sufficient headroom such that a reasonably possible change to key assumptions is unlikely to result in an impairment of the related goodwill.

GSK has assessed the qualitative and quantitative impact of climate related risks on asset recoverable amounts and concluded that there are no material impairments.



## 20. Other intangible assets

<table><tr><td></td><td>Computer software £m</td><td>Licences, patents, amortised brands etc. £m</td><td>Indefinite life brands £m</td><td>Total £m</td></tr><tr><td>Cost at 1 January 2021</td><td>2,403</td><td>20,822</td><td>18,613</td><td>41,838</td></tr><tr><td>Exchange adjustments</td><td>(15)</td><td>(207)</td><td>65</td><td>(157)</td></tr><tr><td>Capitalised development costs</td><td>-</td><td>346</td><td>-</td><td>346</td></tr><tr><td>Other additions</td><td>184</td><td>1,410</td><td>-</td><td>1,594</td></tr><tr><td>Disposals and asset write-offs</td><td>(221)</td><td>(935)</td><td>-</td><td>(1,156)</td></tr><tr><td>Transfer to assets held for sale/distribution</td><td>(1)</td><td>(6)</td><td>(43)</td><td>(50)</td></tr><tr><td>Reclassifications</td><td>74</td><td>9</td><td>(9)</td><td>74</td></tr><tr><td>Cost at 31 December 2021</td><td>2,424</td><td>21,439</td><td>18,626</td><td>42,489</td></tr><tr><td>Exchange adjustments</td><td>63</td><td>934</td><td>1,112</td><td>2,109</td></tr><tr><td>Capitalised development costs</td><td>-</td><td>317</td><td>-</td><td>317</td></tr><tr><td>Additions through business combinations</td><td>-</td><td>2,964</td><td>-</td><td>2,964</td></tr><tr><td>Other additions</td><td>149</td><td>626</td><td>-</td><td>775</td></tr><tr><td>Disposals and asset write-offs</td><td>(203)</td><td>(33)</td><td>-</td><td>(236)</td></tr><tr><td>Transfer to assets held for sale/distribution</td><td>(513)</td><td>(496)</td><td>(19,772)</td><td>(20,781)</td></tr><tr><td>Reclassifications</td><td>39</td><td>(34)</td><td>34</td><td>39</td></tr><tr><td>Cost at 31 December 2022</td><td>1,959</td><td>25,717</td><td>-</td><td>27,676</td></tr><tr><td>Amortisation at 1 January 2021</td><td>(1,322)</td><td>(7,932)</td><td>-</td><td>(9,254)</td></tr><tr><td>Exchange adjustments</td><td>13</td><td>52</td><td>-</td><td>65</td></tr><tr><td>Charge for the year</td><td>(225)</td><td>(956)</td><td>-</td><td>(1,181)</td></tr><tr><td>Disposals and asset write-offs</td><td>165</td><td>572</td><td>-</td><td>737</td></tr><tr><td>Transfer to assets held for sale</td><td>-</td><td>2</td><td>-</td><td>2</td></tr><tr><td>Amortisation at 31 December 2021</td><td>(1,369)</td><td>(8,262)</td><td>-</td><td>(9,631)</td></tr><tr><td>Exchange adjustments</td><td>(33)</td><td>(307)</td><td>-</td><td>(340)</td></tr><tr><td>Charge for the year</td><td>(204)</td><td>(931)</td><td>-</td><td>(1,135)</td></tr><tr><td>Disposals and asset write-offs</td><td>129</td><td>19</td><td>-</td><td>148</td></tr><tr><td>Transfer to assets held for sale/distribution</td><td>254</td><td>300</td><td>-</td><td>554</td></tr><tr><td>Amortisation at 31 December 2022</td><td>(1,223)</td><td>(9,181)</td><td>-</td><td>(10,404)</td></tr><tr><td>Impairment at 1 January 2021</td><td>(28)</td><td>(2,487)</td><td>(245)</td><td>(2,760)</td></tr><tr><td>Exchange adjustments</td><td>-</td><td>5</td><td>-</td><td>5</td></tr><tr><td>Impairment losses</td><td>(93)</td><td>(362)</td><td>-</td><td>(455)</td></tr><tr><td>Reversal of impairments</td><td>-</td><td>2</td><td>37</td><td>39</td></tr><tr><td>Disposals and asset write-offs</td><td>30</td><td>362</td><td>-</td><td>392</td></tr><tr><td>Impairment at 31 December 2021</td><td>(91)</td><td>(2,480)</td><td>(208)</td><td>(2,779)</td></tr><tr><td>Exchange adjustments</td><td>(2)</td><td>(138)</td><td>(1)</td><td>(141)</td></tr><tr><td>Impairment losses</td><td>(72)</td><td>(313)</td><td>(17)</td><td>(402)</td></tr><tr><td>Transfer to assets held for sale/distribution</td><td>10</td><td>34</td><td>226</td><td>270</td></tr><tr><td>Reversal of impairments</td><td>1</td><td>17</td><td>-</td><td>18</td></tr><tr><td>Disposals and asset write-offs</td><td>73</td><td>7</td><td>-</td><td>80</td></tr><tr><td>Impairment at 31 December 2022</td><td>(81)</td><td>(2,873)</td><td>-</td><td>(2,954)</td></tr><tr><td>Total amortisation and impairment at 31 December 2021</td><td>(1,460)</td><td>(10,742)</td><td>(208)</td><td>(12,410)</td></tr><tr><td>Total amortisation and impairment at 31 December 2022</td><td>(1,304)</td><td>(12,054)</td><td>-</td><td>(13,358)</td></tr><tr><td>Net book value at 1 January 2021</td><td>1,053</td><td>10,403</td><td>18,368</td><td>29,824</td></tr><tr><td>Net book value at 31 December 2021</td><td>964</td><td>10,697</td><td>18,418</td><td>30,079</td></tr><tr><td>Net book value at 31 December 2022</td><td>655</td><td>13,663</td><td>-</td><td>14,318</td></tr></table>

The weighted average interest rate for capitalised borrowing costs in the year was 4% (2021: 3%).

The net book value of computer software included £479 million (2021: £526 million) of internally generated costs.

The carrying value at 31 December 2022 of intangible assets, for which impairments have been charged in the year following those impairments, was £83 million (2021: £694 million). The carrying value at 31 December 2022 of intangible assets, for which impairment reversals have been charged in the year following those impairment reversals, was £776 million (2021: £104 million). No individual intangible asset accounted for a material impairment.

The patent expiry dates of the Group’s most significant assets, where relevant, are set out on pages 282 to 284. Please refer to Note 2 to the Group’s accounting policy and estimate of the useful life for intangible assets over the exclusivity and non-exclusivity periods.



## Notes to the financial statements continued

## 20. Other intangible assets continued

Amortisation and impairment losses, net of reversals, have been charged in the income statement as follows:

<table><tr><td rowspan="2"></td><td colspan="3">Amortisation</td><td colspan="2">Net impairment losses</td></tr><tr><td>2022£m</td><td>2021(9)£m</td><td>2022£m</td><td>2021(9)£m</td><td></td></tr><tr><td>Cost of sales</td><td>663</td><td>750</td><td>2</td><td>—</td><td></td></tr><tr><td>Selling, general and administration</td><td>116</td><td>126</td><td>66</td><td>65</td><td></td></tr><tr><td>Research and development</td><td>307</td><td>212</td><td>299</td><td>373</td><td></td></tr><tr><td></td><td>1,086</td><td>1,088</td><td>367</td><td>438</td><td></td></tr></table>

(a) The 2021 comparatives have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see Note 4I).

Licences, patents, amortised brands etc. includes a large number of acquired licences, patents, know-how agreements and marketing rights, which are either marketed or in use, or still in development. Note 4I, 'Acquisitions and disposals' gives details of additions through business combinations in the year. The book values of the largest individual items are as follows:

<table><tr><td></td><td>2022£m</td><td>2021£m</td></tr><tr><td>Tesaro Assets</td><td>2,858</td><td>2,677</td></tr><tr><td>Meningitis portfolio</td><td>1,855</td><td>1,889</td></tr><tr><td>Momelotinib</td><td>1,499</td><td>-</td></tr><tr><td>Affinivax Assets</td><td>1,473</td><td>-</td></tr><tr><td>Dolutegravir</td><td>1,150</td><td>1,093</td></tr><tr><td>Benlysta</td><td>541</td><td>644</td></tr><tr><td>Alector Assets</td><td>509</td><td>509</td></tr><tr><td>iTeos Assets</td><td>443</td><td>444</td></tr><tr><td>Shingrix</td><td>288</td><td>268</td></tr><tr><td>Okairos</td><td>202</td><td>191</td></tr><tr><td>BMS Assets</td><td>196</td><td>219</td></tr><tr><td>Spero</td><td>163</td><td>-</td></tr><tr><td>Vir Assets</td><td>159</td><td>212</td></tr><tr><td>Fluarix/Flulaval</td><td>147</td><td>180</td></tr><tr><td>Stiefel trade name</td><td>142</td><td>151</td></tr><tr><td>CureVac Assets</td><td>106</td><td>164</td></tr><tr><td>Lamisil®</td><td>-</td><td>259</td></tr><tr><td>Others</td><td>1932</td><td>1,797</td></tr><tr><td></td><td>13,663</td><td>10,697</td></tr></table>

(a) Disposed of as part of the Consumer Healthcare demerger (Note 4I).

On 1 July 2022, GSK completed the acquisition of Sierra Oncology Inc. The main asset is momelotinib.

On 15 August 2022, GSK completed the acquisition of Affinivax, Inc.

Indefinite life brands related to healthcare brands used within the Consumer Healthcare business. Indefinite life brands were disposed of as part of the Consumer Healthcare demerger (Note 4I).

The Group do not consider that any reasonably possible changes in the key assumptions would cause the recoverable amount of the Intangible assets disclosed above to fall below their carrying values.

GSK has assessed the qualitative and quantitative impact of climate related risks on asset recoverable amounts and concluded that there are no material impairments.



## 21. Investments in associates and joint ventures

<table><tr><td></td><td>Joint ventures</td><td>Associates</td><td>2022 Total</td><td>Joint ventures</td><td>Associates</td><td>2021 Total</td></tr><tr><td></td><td>£m</td><td>£m</td><td>£m</td><td>£m</td><td>£m</td><td>£M</td></tr><tr><td>At 1 January</td><td>12</td><td>76</td><td>88</td><td>15</td><td>349</td><td>364</td></tr><tr><td>Exchange adjustments</td><td>1</td><td>1</td><td>2</td><td>-</td><td>(15)</td><td>(15)</td></tr><tr><td>Additions</td><td>-</td><td>1</td><td>1</td><td>-</td><td>1</td><td>1</td></tr><tr><td>Disposals</td><td>-</td><td>-</td><td>-</td><td>-</td><td>(278)</td><td>(278)</td></tr><tr><td>Distributions received</td><td>-</td><td>(6)</td><td>(6)</td><td>-</td><td>(9)</td><td>(9)</td></tr><tr><td>Net fair value movements through Other comprehensive income</td><td>-</td><td>(9)</td><td>(9)</td><td>-</td><td>28</td><td>28</td></tr><tr><td>Impairment of interest in associates</td><td>-</td><td>-</td><td>-</td><td>-</td><td>(36)</td><td>(36)</td></tr><tr><td>Profit/(loss) after tax recognised in the consolidated income statement</td><td>(3)</td><td>1</td><td>(2)</td><td>(3)</td><td>36</td><td>33</td></tr><tr><td>At 31 December</td><td>10</td><td>64</td><td>74</td><td>12</td><td>76</td><td>88</td></tr></table>

On 20 May 2021, the Group agreed with Innoviva Inc to sell all of its shares in Innoviva back to Innoviva for £277 million. Following settlement of the transaction, GSK no longer held any Innoviva stock. A loss of £46 million (including £10 million of recycling of exchange differences in Innoviva) is presented in Loss on disposal of interest in associates in the 2021 Consolidated income statement. The transaction did not include any changes in Innoviva's commercial interest in royalties paid by GSK. Loss on disposal of interest in associates in 2021 also includes a £10 million gain from a disposal of another immaterial associate.

Please refer to the Income statement information on associates and joint ventures in Note 13.

## 22. Current equity investments

<table><tr><td></td><td>Investments measured at FVTPL 2022 £m</td></tr><tr><td>Current</td><td>-</td></tr><tr><td>At 1 January</td><td>2</td></tr><tr><td>Exchange adjustments</td><td>3,852</td></tr><tr><td>Additions</td><td>233</td></tr><tr><td>Net fair value movements through profit or loss</td><td>4,087</td></tr></table>

Current equity investments represent Haleon plc shares held after the demerger of Consumer Healthcare. Shares are held for trading and measured at fair value through profit or loss (FVTPL) based on the Haleon plc share price. Changes in fair value after the demerger are presented as Other operating income/expense in continuing operations. The Group’s investment in Haleon plc at the end of December 2022 is held by Glaxo Group Limited (5.4%), Scottish Limited Partnerships (SLPs) which were set up to collateralise agreed additional funding for GSK’s UK Defined Benefit pension schemes (7.5%) (Note 31) and the ESOP Trusts (0.6%). Net fair value movement through profit or loss of £233 million includes a fair value gain of £229 million and £4 million of other adjustments.



## Notes to the financial statements continued

## 23. Other investments

<table><tr><td></td><td>Investments designated as measured at FVTOCI £m</td><td>Investments measured at FVTPL £m</td><td>2022 £m</td><td>Investments designated as measured at FVTOCI £m</td><td>Investments measured at FYTPL £m</td><td>2021 £m</td></tr><tr><td>Non-current</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>At 1 January</td><td>1927</td><td>199</td><td>2,126</td><td>2,939</td><td>121</td><td>3,060</td></tr><tr><td>Exchange adjustments</td><td>75</td><td>25</td><td>100</td><td>5</td><td>-</td><td>5</td></tr><tr><td>Additions</td><td>87</td><td>63</td><td>150</td><td>125</td><td>52</td><td>177</td></tr><tr><td>Net fair value movements through Other comprehensive income</td><td>(716)</td><td>-</td><td>(716)</td><td>(902)</td><td>-</td><td>(902)</td></tr><tr><td>Net fair value movements through profit or loss</td><td>-</td><td>27</td><td>27</td><td>-</td><td>37</td><td>37</td></tr><tr><td>Disposals</td><td>(220)</td><td>-</td><td>(220)</td><td>(240)</td><td>(11)</td><td>(251)</td></tr><tr><td>At 31 December</td><td>1153</td><td>314</td><td>1,467</td><td>1,927</td><td>199</td><td>2,126</td></tr></table>

Non-current other investments comprise non-current equity investments which are recorded at fair value at each balance sheet date. For investments traded in an active market, the fair value is determined by reference to the relevant stock exchange quoted bid price. For other investments, the fair value is estimated by management with reference to relevant available information, including the current market value of similar instruments, recent financing rounds and discounted cash flows of the underlying net assets. Movements arising on the translation of overseas net assets for consolidation into the Group accounts are recorded as Exchange adjustments. Net fair value movements include the impact of other exchange gains of £134 million through Other comprehensive income and £nil through profit or loss (2021: gains of £15 million through Other comprehensive income and £2 million through profit or loss). Other investments include listed investments of £823 million (2021: £1,736 million).

GSK has elected to designate the majority of its equity investments as measured at fair value through Other comprehensive income (FVTOCI). The most significant of these investments held at 31 December 2022 were in Vir Biotechnology, Inc. which had a fair value at 31 December 2022 of £180 million (2021: £266 million) and Nimbus Therapeutics, LLC which had a fair value at 31 December 2022 of £139 million (2021: £32 million). The fair value of the investment in CureVac N.V., disclosed as a significant investment at 31 December 2021, was £75 million at 31 December 2022 (2021: £380 million). The other investments include equity stakes in companies with which GSK has research collaborations and in companies which provide access to biotechnology developments of potential interest.

On disposal of equity investments measured at FVTOCI, the accumulated fair value movements are reclassified from the fair value reserve to retained earnings. Investments measured at FVTOCI with a fair value of £220 million (2021: £240 million) were disposed of during the year. The cumulative gain on these investments after tax was £14 million (2021: £132 million).

Certain other investments, such as investments in funds with limited lives and investments acquired with an intention to sell, are measured at fair value through profit or loss (FVTPL).



## 24. Other non-current assets

<table><tr><td></td><td>2022</td><td>2021</td></tr><tr><td>Amounts receivable under insurance contracts</td><td>857</td><td>849</td></tr><tr><td>Pension schemes in surplus</td><td>229</td><td>741</td></tr><tr><td>Other receivables</td><td>108</td><td>86</td></tr><tr><td></td><td>1,194</td><td>1,676</td></tr></table>

Amounts receivable under insurance contracts are held at cash surrender value with movements through profit or loss.

Within the other receivables of £108 million (2021: £86 million), £34 million (2021: £44 million) is classified as financial assets of which £13 million (2021: £23 million) is classified as fair value through profit or loss. On the remaining balance of £21 million (2021: £21 million), the expected credit loss allowance was immaterial at 31 December 2022 and 2021.

## 25. Inventories

<table><tr><td></td><td>2022</td><td>2021</td></tr><tr><td></td><td>£m</td><td>£m</td></tr><tr><td>Raw materials and consumables</td><td>1,576</td><td>1,772</td></tr><tr><td>Work in progress</td><td>2,286</td><td>1,889</td></tr><tr><td>Finished goods</td><td>1,284</td><td>2,122</td></tr><tr><td></td><td>5,146</td><td>5,783</td></tr></table>

## 26. Trade and other receivables

<table><tr><td></td><td>2022</td><td>2021</td></tr><tr><td></td><td>£m</td><td>£m</td></tr><tr><td>Trade receivables, net of loss allowance</td><td>5,452</td><td>6,246</td></tr><tr><td>Accrued income</td><td>19</td><td>12</td></tr><tr><td>Prepayments</td><td>343</td><td>315</td></tr><tr><td>Interest receivable</td><td>2</td><td>3</td></tr><tr><td>Employee loans and advances</td><td>11</td><td>18</td></tr><tr><td>Other receivables</td><td>1,226</td><td>1,266</td></tr><tr><td></td><td>7,053</td><td>7,860</td></tr></table>

There were no trade or other receivable balances (2021: £nil) due from associates and joint ventures. The most significant component of other receivables comprises receivables for taxes other than corporate income tax. Other significant balances within other receivables are royalties receivable and amounts receivable from collaboration partners.

<table><tr><td>Loss allowance - trade receivables</td><td>2022</td><td>2021</td></tr><tr><td></td><td>£m</td><td>£m</td></tr><tr><td>At 1 January</td><td>150</td><td>151</td></tr><tr><td>Exchange adjustments</td><td>9</td><td>(3)</td></tr><tr><td>Charge for the year</td><td>35</td><td>52</td></tr><tr><td>Transfer to assets held for sale</td><td>(60)</td><td>-</td></tr><tr><td>Subsequent recoveries of amounts provided for</td><td>(19)</td><td>(39)</td></tr><tr><td>Utilised</td><td>(24)</td><td>(11)</td></tr><tr><td>At 31 December</td><td>91</td><td>150</td></tr></table>

Of the total trade receivables balance, £58 million (2021: £86 million) is considered credit impaired, against which a £26 million (2021: £4 million) expected credit loss allowance has been applied. No amount was purchased or originated credit impaired.

Within the other receivables of £1,226 million (2021: £1,266 million), £683 million (2021: £553 million) is classified as financial assets of which £nil (2021: £nil) is classified as held at fair value through profit or loss. At 31 December 2022 an expected credit loss allowance of £6 million (2021: £5 million) was recognised in respect of financial assets with no charge reported in profit or loss during the year.

For more discussion on credit risk practices, please refer to Note 44.



## 27. Cash and cash equivalents

<table><tr><td></td><td>2022
£m</td><td>2021
£m</td></tr><tr><td>Cash at bank and in hand</td><td>879</td><td>1,427</td></tr><tr><td>Short-term deposits</td><td>2,844</td><td>2,847</td></tr><tr><td></td><td>3,723</td><td>4,274</td></tr></table>

During 2022 £1,421 million was transferred to assets held for sale relating to the Consumer Healthcare business that was demerged during the year (see Note 41). Cash and cash equivalents included £0.2 billion (2021: £0.2 billion) not available for general use due to restrictions applying in the subsidiaries where it is held. Restrictions include exchange controls and taxes on repatriation.

## 28. Assets held for sale

<table><tr><td></td><td>2022
£m</td><td>2021
£m</td></tr><tr><td>Property, plant and equipment</td><td>83</td><td>22</td></tr><tr><td>Other</td><td>15</td><td>—</td></tr><tr><td></td><td>98</td><td>22</td></tr></table>

Non-current assets and disposal groups are transferred to assets held for sale when it is expected that their carrying amounts will be recovered principally through disposal and a sale is considered highly probable. They are held at the lower of carrying amount and fair value less costs to sell.

In Q2 2022, the Consumer Healthcare business was classified as held for sale. Following completion of the demerger of the Consumer Healthcare business in Q3 2022, a total of £12.9 billion of net assets and liabilities were distributed/derecognised as part of the gain on the demerger.



## 29. Trade and other payables

<table><tr><td></td><td>2022
£m</td><td>2021
£m</td></tr><tr><td>Trade payables</td><td>3,866</td><td>4,535</td></tr><tr><td>Wages and salaries</td><td>1,488</td><td>1,470</td></tr><tr><td>Social security</td><td>126</td><td>152</td></tr><tr><td>ViV Healthcare put option</td><td>1,093</td><td>1,008</td></tr><tr><td>Other payables</td><td>418</td><td>518</td></tr><tr><td>Deferred income</td><td>299</td><td>307</td></tr><tr><td>Customer return and rebate accruals</td><td>6,627</td><td>6,322</td></tr><tr><td>Other accruals</td><td>2,346</td><td>3,242</td></tr><tr><td></td><td>16,263</td><td>17,554</td></tr></table>

Trade and other payables included £nil (2021: £nil) due to associates and joint ventures. The Group provides limited supplier financing arrangements to certain customers. The amounts involved at 31 December 2022 were not material.

Revenue recognised in the year that was included in deferred income at 1 January 2022 was £85 million (2021: £29 million).

Customer return and rebate accruals are provided for by the Group at the point of sale in respect of estimated rebates, discounts or allowances payable to customers as more fully described in the Group financial review on page 94. At 31 December 2022, Customer return and rebate accruals included £5,717 million (2021: £5,044 million) in respect of US Commercial Operations. Accruals are made at the time of sale but the actual amounts paid are based on claims made some time after the initial recognition of the sale. As the amounts are estimated, they may not fully reflect the final outcome and are subject to change dependent upon, amongst other things, the types of buying group and product sales mix. The level of accrual is reviewed and adjusted quarterly in light of historical experience of actual amounts paid and any changes in arrangements. Future events could cause the assumptions on which the accruals are based to change, which could affect the future results of the Group.

Pfizer’s put option over its shareholding in ViiV Healthcare is currently exercisable. Pfizer may request an IPO of ViiV Healthcare at any time and if either GSK does not consent to such IPO or an offering is not completed within nine months, Pfizer could require GSK to acquire its shareholding. The amount of the liability for this put option, which is held on the gross redemption basis, is derived from an internal valuation of the ViiV Healthcare business, utilising both discounted forecast future cash flow and multiples-based methodologies.

The table below shows on an indicative basis the income statement and balance sheet sensitivity of the Pfizer put option to reasonably possible changes in key assumptions.

<table><tr><td>Increase/(decrease) in financial liability and loss/(gain) in Income statement</td><td>2022
£m</td><td>2021
£m</td></tr><tr><td>10% increase in sales forecasts*</td><td>100</td><td>89</td></tr><tr><td>15% increase in sales forecasts*</td><td>149</td><td>133</td></tr><tr><td>10% decrease in sales forecasts*</td><td>(99)</td><td>(89)</td></tr><tr><td>15% decrease in sales forecasts*</td><td>(149)</td><td>(134)</td></tr><tr><td>1% (100 basis points) increase in discount rate</td><td>(32)</td><td>(30)</td></tr><tr><td>1.50% (150 basis points) increase in discount rate</td><td>(48)</td><td>(45)</td></tr><tr><td>1% (100 basis points) decrease in discount rate</td><td>35</td><td>34</td></tr><tr><td>1.50% (150 basis points) decrease in discount rate</td><td>53</td><td>50</td></tr><tr><td>10 cent appreciation of US Dollar</td><td>66</td><td>55</td></tr><tr><td>15 cent appreciation of US Dollar</td><td>103</td><td>81</td></tr><tr><td>10 cent depreciation of US Dollar</td><td>(56)</td><td>(47)</td></tr><tr><td>15 cent depreciation of US Dollar</td><td>(80)</td><td>(64)</td></tr><tr><td>10 cent appreciation of Euro</td><td>29</td><td>26</td></tr><tr><td>15 cent appreciation of Euro</td><td>46</td><td>41</td></tr><tr><td>10 cent depreciation of Euro</td><td>(24)</td><td>(22)</td></tr><tr><td>15 cent depreciation of Euro</td><td>(35)</td><td>(32)</td></tr></table>

* The sales forecast is for ViiV Healthcare sales only in respect of the ViiV Healthcare put option.

Other accruals includes interest accrued on financial liabilities at amortised cost of £207 million (2021: £244 million).

An explanation of the accounting for ViiV Healthcare is set out on page 71.



## Notes to the financial statements continued

## 30. Net debt

<table><tr><td></td><td>Listing exchange</td><td>2022
£m</td><td>2021
£m</td></tr><tr><td>Current assets:</td><td></td><td></td><td></td></tr><tr><td>Liquid investments</td><td></td><td>67</td><td>61</td></tr><tr><td>Cash and cash equivalents</td><td></td><td>3,723</td><td>4,274</td></tr><tr><td></td><td></td><td>3,790</td><td>4,335</td></tr><tr><td>Short-term borrowings:</td><td></td><td></td><td></td></tr><tr><td>Commercial paper</td><td></td><td>(1,191)</td><td>(252)</td></tr><tr><td>Bank loans, overdrafts and other</td><td></td><td>(448)</td><td>(550)</td></tr><tr><td>2.850% US\( US Medium Term Note 2022</td><td>New York Stock Exchange</td><td>-</td><td>(1,483)</td></tr><tr><td>2.875% US\) US Medium Term Note 2022</td><td>New York Stock Exchange</td><td>-</td><td>(1,113)</td></tr><tr><td>0.125% € European Medium Term Note 2023</td><td>London Stock Exchange</td><td>(665)</td><td>-</td></tr><tr><td>0.000% € European Medium Term Note 2023</td><td>London Stock Exchange</td><td>(443)</td><td>-</td></tr><tr><td>0.534% US\( Medium Term Note 2023</td><td>New York Stock Exchange</td><td>(1,038)</td><td>-</td></tr><tr><td>Lease liabilities</td><td></td><td>(167)</td><td>(203)</td></tr><tr><td></td><td></td><td>(3,952)</td><td>(3,601)</td></tr><tr><td>Long-term borrowings:</td><td></td><td></td><td></td></tr><tr><td>2.800% US\) US Medium Term Note 2023</td><td>New York Stock Exchange</td><td>-</td><td>(926)</td></tr><tr><td>0.125% € Euro Medium Term Note 2023</td><td>London Stock Exchange</td><td>-</td><td>(629)</td></tr><tr><td>3.375% US\( US Medium Term Note 2023</td><td>New York Stock Exchange</td><td>-</td><td>(925)</td></tr><tr><td>0.000% US\) US Medium Term Note 2023</td><td>New York Stock Exchange</td><td>-</td><td>(204)</td></tr><tr><td>0.000% € Euro Medium Term Note 2023</td><td>London Stock Exchange</td><td>-</td><td>(420)</td></tr><tr><td>0.534% US\( US Medium Term Note 2023</td><td>New York Stock Exchange</td><td>-</td><td>(926)</td></tr><tr><td>3.000% US\) US Medium Term Note 2023</td><td>New York Stock Exchange</td><td>(829)</td><td>(739)</td></tr><tr><td>1.375% € Euro Medium Term Note 2024</td><td>London Stock Exchange</td><td>(884)</td><td>(836)</td></tr><tr><td>4.000% € Euro Medium Term Note 2025</td><td>London Stock Exchange</td><td>(663)</td><td>(627)</td></tr><tr><td>3.625% US\( US Medium Term Note 2025</td><td>New York Stock Exchange</td><td>(827)</td><td>(738)</td></tr><tr><td>1.000% € Euro Medium Term Note 2026</td><td>London Stock Exchange</td><td>(620)</td><td>(587)</td></tr><tr><td>1.250% € Euro Medium Term Note 2026</td><td>London Stock Exchange</td><td>(885)</td><td>(838)</td></tr><tr><td>3.000% € Euro Medium Term Note 2027</td><td>London Stock Exchange</td><td>(442)</td><td>-</td></tr><tr><td>3.375% € Euro Medium Term Note 2027</td><td>London Stock Exchange</td><td>(306)</td><td>(595)</td></tr><tr><td>3.875% US\) US Medium Term Note 2028</td><td>New York Stock Exchange</td><td>(1,450)</td><td>(1,294)</td></tr><tr><td>1.250% € Euro Medium Term Note 2028</td><td>London Stock Exchange</td><td>(744)</td><td>(743)</td></tr><tr><td>3.375% US\( US Medium Term Note 2029</td><td>New York Stock Exchange</td><td>(822)</td><td>(733)</td></tr><tr><td>1.375% € Euro Medium Term Note 2029</td><td>London Stock Exchange</td><td>(441)</td><td>(418)</td></tr><tr><td>1.750% € Euro Medium Term Note 2030</td><td>London Stock Exchange</td><td>(663)</td><td>(628)</td></tr><tr><td>3.125% € Euro Medium Term Note 2032</td><td>London Stock Exchange</td><td>(616)</td><td>-</td></tr><tr><td>5.250% € Euro Medium Term Note 2033 \(</td><td>London Stock Exchange</td><td>(640)</td><td>(984)</td></tr><tr><td>5.375% US\) US Medium Term Note 2034</td><td>London Stock Exchange</td><td>(412)</td><td>(368)</td></tr><tr><td>1.625% € Euro Medium Term Note 2035</td><td>London Stock Exchange</td><td>(744)</td><td>(744)</td></tr><tr><td>6.375% US\( US Medium Term Note 2038</td><td>New York Stock Exchange</td><td>(2,264)</td><td>(2,022)</td></tr><tr><td>6.375% € Euro Medium Term Note 2039 \(</td><td>London Stock Exchange</td><td>(695)</td><td>(695)</td></tr><tr><td>5.250% € Euro Medium Term Note 2042</td><td>London Stock Exchange</td><td>(472)</td><td>(987)</td></tr><tr><td>4.200% US\) US Medium Term Note 2043</td><td>New York Stock Exchange</td><td>(408)</td><td>(364)</td></tr><tr><td>4.250% € Euro Medium Term Note 2045</td><td>London Stock Exchange</td><td>(366)</td><td>(789)</td></tr><tr><td>Other long-term borrowings</td><td></td><td>(1)</td><td>(1)</td></tr><tr><td>Lease liabilities</td><td></td><td>(841)</td><td>(812)</td></tr><tr><td></td><td></td><td>(17,035)</td><td>(20,572)</td></tr><tr><td>Net debt</td><td></td><td>(17,197)</td><td>(19,838)</td></tr></table>

(1) Partially purchased and cancelled on 13 February 2023.



## Notes to the financial statements continued

## 30. Net debt continued

## Current assets

Liquid investments are classified as financial assets at amortised cost. At 31 December 2022, they included US Treasury Notes and other government bonds. The effective interest rate on liquid investments at 31 December 2022 was approximately 0.1% (2021: approximately 0.1%). Liquid investment balances at 31 December 2022 earning interest at floating rates amount to £67 million (2021: £2 million). Liquid investment balances at 31 December 2022 earning interest at fixed rates amount to £nil (2021: £59 million).

Balances reported within cash and cash equivalents have an original maturity of three months or less. The effective interest rate on cash and cash equivalents at 31 December 2022 was approximately 3.1% (2021: approximately 0.6%). Cash and cash equivalents at 31 December 2022 earning interest at floating and fixed rates amounted to £3,441 million and £10 million respectively (2021: £3,906 million and £39 million) and non-interest bearing holdings amounted to £272 million (2021: £329 million).

GSK’s policy regarding the credit quality of cash and cash equivalents is set out in Note 44, ‘Financial instruments and related disclosures’.

## Short-term borrowings

GSK has a $10 billion (£8.3 billion) US commercial paper programme, of which $900 million (£748 million) was in issue at 31 December 2022 (2021: $nil). GSK has a £5 billion Euro commercial paper programme, of which €500 million (£443 million) was in issue at 31 December 2022 (2021: €300 million (£252 million)). In February 2022 GSK cancelled the £1.9 billion three year and $2.5 billion (£2.1 billion) 364 day committed facilities and replaced them with new revolving credit facilities of equivalent size with maturities in September 2025 and September 2023 respectively. Post separation of the Consumer Healthcare business these facilities were reduced to £1.6 billion and $2.2 billion (£1.8 billion) respectively.

The weighted average interest rate on commercial paper borrowings at 31 December 2022 was 3.5% (2021: -0.5%).

The weighted average interest rate on current bank loans and overdrafts at 31 December 2022 was 7.8% (2021: 79%).

The average effective pre-swap interest rate of notes classified as short-term at 31 December 2022 was 0.4% (2021: 3.0%).

## Long-term borrowings

At the year-end, GSK had long-term borrowings of £17.0 billion (2021: £20.6 billion), of which £11.1 billion (2021: £11.7 billion) fell due in more than five years.

During 2022, three bonds were repaid earlier than original maturity, those being the 2.800% US\( US Medium Term Note 2023, the 3.375% US\) US Medium Term Note 2023 and the 0.000% US\( US Medium Term Note 2023. Also, during 2022 GSK undertook a tender on outstanding Sterling Notes, repaying face values of £292 million on the 3.375% £ Euro Medium Term Note 2027, £350 million on the 5.250% £ Euro Medium Term Note 2033, £522 million on the 5.250% £ Euro Medium Term Note 2042 and £429 million on the 4.250% £ Euro Medium Term Note 2045.

The average effective pre-swap interest rate of all notes in issue at 31 December 2022 was approximately 3.5% (2021: approximately 3.3%).

Long-term borrowings repayable after five years carry interest at effective rates between 1.4% and 6.4%, with repayment dates ranging from 2027 to 2045.

Both effective rates exclude the impact of one-off premiums associated with the early repayment of the Sterling Notes.

## Pledged assets

The Group held pledged investments in US Treasury Notes with a par value of $56 million (£47 million), (2021: $56 million (£42 million)) as security against irrevocable letters of credit issued on the Group's behalf in respect of the Group's self-insurance activity. Provisions in respect of self-insurance are included within the provisions for legal and other disputes discussed in Note 32. 'Other provisions'.

## Lease liabilities

The maturity analysis of discounted lease liabilities recognised on the Group balance sheet is as follows:

<table><tr><td></td><td>2022£m</td><td>2021£m</td></tr><tr><td>Rental payments due within one year</td><td>167</td><td>203</td></tr><tr><td>Rental payments due between one and two years</td><td>201</td><td>185</td></tr><tr><td>Rental payments due between two and three years</td><td>127</td><td>120</td></tr><tr><td>Rental payments due between three and four years</td><td>97</td><td>93</td></tr><tr><td>Rental payments due between four and five years</td><td>80</td><td>73</td></tr><tr><td>Rental payments due after five years</td><td>336</td><td>341</td></tr><tr><td>Total lease liabilities</td><td>1,008</td><td>1,015</td></tr></table>



## 31. Pensions and other post-employment benefits

<table><tr><td>Pension and other post-employment costs</td><td>2022
£m</td><td>2021(1)</td><td>2020(2)</td></tr><tr><td>UK pension schemes</td><td>114</td><td>185</td><td>239</td></tr><tr><td>US pension schemes</td><td>48</td><td>40</td><td>58</td></tr><tr><td>Other overseas pension schemes</td><td>154</td><td>153</td><td>170</td></tr><tr><td>Unfunded post-retirement healthcare schemes</td><td>53</td><td>37</td><td>(1)</td></tr><tr><td></td><td>369</td><td>415</td><td>466</td></tr><tr><td>Analysed as:</td><td></td><td></td><td></td></tr><tr><td>Funded defined benefit/hybrid pension schemes</td><td>152</td><td>231</td><td>318</td></tr><tr><td>Unfunded defined benefit pension schemes</td><td>31</td><td>23</td><td>30</td></tr><tr><td>Unfunded post-retirement healthcare schemes</td><td>53</td><td>37</td><td>(1)</td></tr><tr><td>Defined benefit schemes</td><td>236</td><td>291</td><td>347</td></tr><tr><td>Defined contribution pension schemes</td><td>133</td><td>124</td><td>119</td></tr><tr><td></td><td>369</td><td>415</td><td>466</td></tr></table>

The costs of the defined benefit pension and post-retirement healthcare schemes are charged in the income statement as follows:

<table><tr><td></td><td>2022</td><td>2021(1)</td><td>2020(2)</td></tr><tr><td></td><td>£m</td><td>£m</td><td>£m</td></tr><tr><td>Cost of sales</td><td>104</td><td>106</td><td>128</td></tr><tr><td>Selling, general and administration</td><td>90</td><td>136</td><td>167</td></tr><tr><td>Research and development</td><td>42</td><td>49</td><td>52</td></tr><tr><td></td><td>236</td><td>291</td><td>347</td></tr></table>

(a) The 2021 and 2020 comparatives have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see Note 4I).

GSK entities operate pension arrangements which cover the Group’s material obligations to provide pensions to retired employees. These arrangements have been developed in accordance with local practices in the countries concerned. Pension benefits can be provided by state schemes; by defined contribution schemes, whereby retirement benefits are determined by the value of funds arising from contributions paid in respect of each employee; or by defined benefit schemes, whereby retirement benefits are based on employee pensionable remuneration and length of service.

Pension costs of defined benefit schemes for accounting purposes have been calculated using the projected unit credit method. In certain countries pension benefits are provided on an unfunded basis, some administered by trustee companies. Formal, independent, actuarial valuations of the Group’s main plans are undertaken regularly, normally at least every three years.

Remeasurement movements in the year are recognised through the statement of comprehensive income. Discount rates are derived from AA rated corporate bond yields except in countries where there is no deep market in corporate bonds where government bond yields are used. Discount rates are selected to reflect the term of the expected benefit payments. Projected inflation rates and pension increases are long-term predictions based on the yield gap between long-term index-linked and fixed interest Gilts. In the UK, mortality rates are determined by adjusting the SAPS S3 standard mortality tables to reflect recent scheme experience. These rates are then projected to reflect improvements in life expectancy in line with the CMI 2021 projections with a long-term rate of improvement of 1.0% per year for both males and females. In the US, mortality rates are calculated using the PRI-2012 white collar table adjusted to reflect recent experience. These rates are projected using MP-2020 to allow for future improvements in life expectancy.



## Notes to the financial statements continued

## 31. Pensions and other post-employment benefits continued

The average life expectancy assumed now for an individual at the age of 60 and projected to apply in 2042 for an individual then at the age of 60 is as follows:

<table><tr><td rowspan="2"></td><td colspan="4">UK</td><td>US</td></tr><tr><td>Male Years</td><td>Female Years</td><td>Male Years</td><td>Female Years</td><td></td></tr><tr><td>Current</td><td>273</td><td>28.2</td><td>273</td><td>28.6</td><td></td></tr><tr><td>Projected for 2042</td><td>28.5</td><td>29.5</td><td>28.8</td><td>30.1</td><td></td></tr></table>

The assets of funded schemes are generally held in separately administered trusts, either as specific assets or as a proportion of a general fund, or are insurance contracts. Assets are invested in different classes in order to maintain a balance between risk and return. Investments are diversified to limit the financial effect of the failure of any individual investment. The physical asset allocation strategy for three of the four UK plans is 36% in return-seeking assets and 64% in liability-matching assets. During 2019, a buy-in insurance contract was purchased to cover substantially all of the obligations of the other UK plan. At 31 December 2022, the value of the insurance contract was £402 million (2021: £570 million). The asset allocation of the US plans is currently set at 25% return-seeking assets and 75% liability-matching assets.

The pension plans are exposed to risk that arises because the estimated market value of the plans’ assets might decline, the investment returns might reduce, or the estimated value of the plans’ liabilities might increase.

In line with the agreed mix of return-seeking assets to generate future returns and liability-matching assets to better match future pension obligations, the Group has defined an overall long-term investment strategy for the plans, with investments across a broad range of assets. The main market risks within the asset and hedging portfolio are against credit risk, interest rates, long-term inflation, equities, property, currency and bank counterparty risk.

The plan liabilities are a series of future cash flows with relatively long duration. On an IAS 19 basis, these cash flows are sensitive to changes in the expected long-term inflation rate and the discount rate (AA corporate bond yield curve) where an increase in long-term inflation corresponds with an increase in the liabilities, and an increase in the discount rate corresponds with a decrease in the liabilities.

The interest rate risk and credit rate risk in the US are partially hedged. The targets are based on an accounting measure of the plan liabilities.

For the UK plans, there is an interest rate and inflation hedging strategy in place. The targets are based on an economic measure of the plan liabilities.

In the UK, the defined benefit pension schemes operated for the benefit of former Glaxo Wellcome employees and former SmithKline Beecham employees remain separate. These schemes were closed to new entrants in 2001 and subsequent UK employees are entitled to join a defined contribution scheme. In addition, the Group operates a number of post-retirement healthcare schemes, the principal one of which is in the US.

Following a period of consultation with impacted employees, it was announced on 17 December 2020 that the UK defined benefit plans would be closed to future accrual effective from 31 March 2022. As a result, post closure the accrued benefits of active participants will be revalued in line with inflation (RPI for the legacy Glaxo Wellcome plans and CPI for the legacy SmithKline Beecham plans subject to the relevant caps for each arrangement) rather than capped pay increases. In addition, all defined benefit plan participants who were still active at 1 April 2022 received a defined pension contribution of £10,000 each. The effect of closure and the defined contribution enhancement together resulted in a one-off cost of £74 million in 2020. As announced, the plan was closed to new entrants at 31 March 2022. From 1 April 2022, former defined benefits plans employees were transferred to the defined contribution plans.

It was announced on 9 September 2020 that the US cash balance pension plans would be closed to future accrual from 1 January 2021. This change resulted in a credit of £56 million. On 1 June 2020 and 9 September 2020, two amendments were made to the retiree healthcare plans in the US resulting in a credit of £55 million.

The Group has applied the following financial assumptions in assessing the defined benefit liabilities:

<table><tr><td rowspan="2"></td><td colspan="4">UK</td><td colspan="4">US</td><td colspan="2">Rest of World</td></tr><tr><td>2022 % pa</td><td>2021 % pa</td><td>2020 % pa</td><td>2022 % pa</td><td>2021 % pa</td><td>2020 % pa</td><td></td><td>2022 % pa</td><td>2021 % pa</td><td>2020 % pa</td></tr><tr><td>Rate of increase of future earnings</td><td>n/a</td><td>2.00</td><td>2.00</td><td>n/a</td><td>n/a</td><td>n/a</td><td>3.40</td><td>2.90</td><td>2.60</td><td></td></tr><tr><td>Discount rate</td><td>4.80</td><td>2.00</td><td>1.40</td><td>5.30</td><td>2.70</td><td>2.30</td><td>3.40</td><td>1.10</td><td>0.60</td><td></td></tr><tr><td>Expected pension increases</td><td>3.10</td><td>3.20</td><td>2.80</td><td>n/a</td><td>n/a</td><td>n/a</td><td>2.40</td><td>2.30</td><td>2.10</td><td></td></tr><tr><td>Cash balance credit/conversion rate</td><td>n/a</td><td>n/a</td><td>n/a</td><td>3.90</td><td>2.00</td><td>1.90</td><td>0.80</td><td>0.20</td><td>0.10</td><td></td></tr><tr><td>Inflation rate</td><td>3.10</td><td>3.20</td><td>2.80</td><td>2.50</td><td>2.25</td><td>2.00</td><td>2.30</td><td>1.90</td><td>1.30</td><td></td></tr></table>

Sensitivity analysis detailing the effect of changes in assumptions is provided on page 228. The analysis provided reflects the assumption changes which have the most material impact on the results of the Group.



## Notes to the financial statements continued

## 31. Pensions and other post-employment benefits continued

The amounts recorded in the income statement and statement of comprehensive income for the three years ended 31 December 2022 in relation to the defined benefit pension and post-retirement healthcare schemes were as follows:

<table><tr><td></td><td></td><td></td><td></td><td colspan="2">Pensions</td><td>Post-retirement benefits</td></tr><tr><td>2022</td><td>UK</td><td>US</td><td>Rest of World</td><td>Group</td><td>Group</td><td></td></tr><tr><td>Amounts charged to operating profit</td><td>£m</td><td>£m</td><td>£m</td><td>£m</td><td>£m</td><td></td></tr><tr><td>Current service cost</td><td>13</td><td>7</td><td>126</td><td>146</td><td>22</td><td></td></tr><tr><td>Past service cost</td><td>6</td><td>-</td><td>-</td><td>6</td><td>-</td><td></td></tr><tr><td>Net interest cost</td><td>(11)</td><td>20</td><td>9</td><td>18</td><td>32</td><td></td></tr><tr><td>Gains from settlements</td><td>-</td><td>-</td><td>(22)</td><td>(22)</td><td>-</td><td></td></tr><tr><td>Expenses</td><td>14</td><td>21</td><td>-</td><td>35</td><td>(1)</td><td></td></tr><tr><td></td><td>22</td><td>48</td><td>113</td><td>183</td><td>53</td><td></td></tr><tr><td>Remeasurement gains/(losses) recorded in the statement of comprehensive income(1)</td><td>(1169)</td><td>36</td><td>261</td><td>(872)</td><td>228</td><td></td></tr></table>

<table><tr><td></td><td></td><td></td><td></td><td colspan="2">Pensions</td><td>Post-retirement benefits</td></tr><tr><td>2021(2)</td><td>UK</td><td>US</td><td>Rest of World</td><td>Group</td><td>Group</td><td></td></tr><tr><td>Amounts charged to operating profit</td><td>£m</td><td>£m</td><td>£m</td><td>£m</td><td>£m</td><td></td></tr><tr><td>Current service cost</td><td>53</td><td>9</td><td>119</td><td>181</td><td>17</td><td></td></tr><tr><td>Past service cost/(credit)</td><td>27</td><td>2</td><td>(10)</td><td>19</td><td>(3)</td><td></td></tr><tr><td>Net interest (income)/cost</td><td>3</td><td>18</td><td>7</td><td>28</td><td>22</td><td></td></tr><tr><td>Gains from settlements</td><td>-</td><td>-</td><td>(2)</td><td>(2)</td><td>-</td><td></td></tr><tr><td>Expenses</td><td>15</td><td>12</td><td>2</td><td>29</td><td>-</td><td></td></tr><tr><td></td><td>98</td><td>41</td><td>116</td><td>255</td><td>36</td><td></td></tr><tr><td>Remeasurement gains/(losses) recorded in the statement of comprehensive income</td><td>572</td><td>98</td><td>186</td><td>856</td><td>68</td><td></td></tr></table>

<table><tr><td></td><td></td><td></td><td></td><td colspan="2">Pensions</td><td>Post-retirement benefits</td></tr><tr><td>2020(2)</td><td>UK</td><td>US</td><td>Rest of World</td><td>Group</td><td>Group</td><td></td></tr><tr><td>Amounts charged to operating profit</td><td>£m</td><td>£m</td><td>£m</td><td>£m</td><td>£m</td><td></td></tr><tr><td>Current service cost</td><td>58</td><td>72</td><td>125</td><td>255</td><td>22</td><td></td></tr><tr><td>Past service cost/(credit)</td><td>93</td><td>(49)</td><td>1</td><td>45</td><td>(53)</td><td></td></tr><tr><td>Net interest (income)/cost</td><td>3</td><td>23</td><td>8</td><td>34</td><td>36</td><td></td></tr><tr><td>Gains from settlements</td><td>-</td><td>12</td><td>(7)</td><td>5</td><td>(6)</td><td></td></tr><tr><td>Expenses</td><td>9</td><td>-</td><td>-</td><td>9</td><td>-</td><td></td></tr><tr><td></td><td>163</td><td>58</td><td>127</td><td>348</td><td>(1)</td><td></td></tr><tr><td>Remeasurement losses recorded in the statement of comprehensive income</td><td>51</td><td>(96)</td><td>(45)</td><td>(90)</td><td>(73)</td><td></td></tr></table>

The amounts included within past service costs in the UK included £6 million (2021 \( ^{(2)} $ : £26 million; 2020 \( ^{(2)} $ : £23 million) of augmentation costs which arose from Major restructuring programmes, together with a charge of £nil (2021: £nil; 2020 \( ^{(2)} $ : £70 million) in relation to the impact of the closure of the defined benefit schemes to future accrual.

In 2020, the past service credit of £49 million in the US reflected the closure of the cash balance pension plans from 1 January 2021. Amendments to the retiree healthcare plan in the US in 2020 \( ^{(2)} \)  resulted in a credit of £53 million to past service costs in post-retirement benefits in 2020.

(1) These numbers do not include remeasurement gains/(losses) related to the demerged Consumer Healthcare business.

(2) The 2021 and 2020 comparatives have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see Note 4I).



## Notes to the financial statements continued

## 31. Pensions and other post-employment benefits continued

A summarised balance sheet presentation of the Group defined benefit pension schemes and other post-retirement benefits is set out in the table below:

<table><tr><td></td><td>2022
£m</td><td>2021
£m</td><td>2020
£m</td></tr><tr><td>Recognised in Other non-current assets:</td><td></td><td></td><td></td></tr><tr><td>Pension schemes in surplus</td><td>229</td><td>741</td><td>183</td></tr><tr><td>Recognised in Pensions and other post-employment benefits:</td><td></td><td></td><td></td></tr><tr><td>Pension schemes in deficit</td><td>(1,585)</td><td>(1,870)</td><td>(2,287)</td></tr><tr><td>Post-retirement benefits</td><td>(994)</td><td>(1,243)</td><td>(1,363)</td></tr><tr><td></td><td>(2,579)</td><td>(3,113)</td><td>(3,650)</td></tr></table>

In the event of a plan wind-up, GSK believes the UK pension scheme rules provide the company with the right to a refund of surplus assets following the full settlement of plan liabilities. As a result, the net surplus in the UK defined benefit pension schemes is recognised in full.

The fair values of the assets and liabilities of the UK and US defined benefit pension schemes, together with aggregated data for other defined benefit pension schemes in the Group are as follows:

<table><tr><td>At 31 December 2022</td><td></td><td>UK
£m</td><td>US
£m</td><td>Rest of World
£m</td><td>Group
£m</td></tr><tr><td rowspan="2">Equities:</td><td>- listed</td><td>1,351</td><td>437</td><td>371</td><td>2,159</td></tr><tr><td>- unlisted</td><td>-</td><td>-</td><td>2</td><td>2</td></tr><tr><td>Multi-asset funds</td><td></td><td>1,101</td><td>-</td><td>-</td><td>1,101</td></tr><tr><td rowspan="2">Property:</td><td>- listed</td><td>-</td><td>-</td><td>19</td><td>19</td></tr><tr><td>- unlisted</td><td>464</td><td>140</td><td>1</td><td>605</td></tr><tr><td rowspan="2">Corporate bonds:</td><td>- listed</td><td>1,692</td><td>779</td><td>124</td><td>2,595</td></tr><tr><td>- unlisted</td><td>-</td><td>-</td><td>15</td><td>15</td></tr><tr><td>Government bonds:</td><td>- listed</td><td>4,048</td><td>723</td><td>558</td><td>5,329</td></tr><tr><td>Insurance contracts</td><td></td><td>1,003</td><td>-</td><td>691</td><td>1,694</td></tr><tr><td>Other (liabilities)/assets</td><td></td><td>(645)</td><td>181</td><td>89</td><td>(375)</td></tr><tr><td>Fair value of assets</td><td></td><td>9,014</td><td>2,260</td><td>1,870</td><td>13,144</td></tr><tr><td>Present value of scheme obligations</td><td></td><td>(9,117)</td><td>(3,030)</td><td>(2,353)</td><td>(14,500)</td></tr><tr><td>Net surplus/(obligation)</td><td></td><td>(103)</td><td>(770)</td><td>(483)</td><td>(1,356)</td></tr><tr><td>Included in Other non-current assets</td><td></td><td>109</td><td>-</td><td>120</td><td>229</td></tr><tr><td>Included in Pensions and other post-employment benefits</td><td></td><td>(212)</td><td>(770)</td><td>(603)</td><td>(1,585)</td></tr><tr><td></td><td></td><td>(103)</td><td>(770)</td><td>(483)</td><td>(1,356)</td></tr><tr><td>Actual return on plan assets</td><td></td><td>(4,710)</td><td>(253)</td><td>(550)</td><td>(5,513)</td></tr></table>

The multi-asset funds comprise investments in pooled investment vehicles that are invested across a range of asset classes, increasing diversification within the growth portfolio. The value of funds in this asset class with a quoted market price is £211 million (2021: £350 million).

The ‘Other (liabilities)/assets’ category comprises cash and mark to market values of derivative positions.

Index-linked gilts held as part of a UK repo programme are included in government bonds. The related loan of £2,376 million at 31 December 2022 (2021: £513 million; 2020: £650 million) is deducted within ‘Other assets’.



## Notes to the financial statements continued

## 31. Pensions and other post-employment benefits continued

<table><tr><td>At 31 December 2021</td><td>UK
£m</td><td>US
£m</td><td>Rest of World
£m</td><td>Group
£m</td></tr><tr><td>Equities:</td><td>- listed</td><td>3,954</td><td>522</td><td>731</td></tr><tr><td></td><td>- unlisted</td><td>-</td><td>-</td><td>4</td></tr><tr><td>Multi-asset funds</td><td></td><td>1,415</td><td>-</td><td>-</td></tr><tr><td>Property:</td><td>- listed</td><td>-</td><td>-</td><td>68</td></tr><tr><td></td><td>- unlisted</td><td>502</td><td>154</td><td>1</td></tr><tr><td>Corporate bonds:</td><td>- listed</td><td>1,503</td><td>975</td><td>140</td></tr><tr><td></td><td>- unlisted</td><td>-</td><td>-</td><td>15</td></tr><tr><td>Government bonds:</td><td>- listed</td><td>5,054</td><td>724</td><td>984</td></tr><tr><td>Insurance contracts</td><td></td><td>1,334</td><td>-</td><td>917</td></tr><tr><td>Other (liabilities)/assets</td><td></td><td>(130)</td><td>149</td><td>72</td></tr><tr><td>Fair value of assets</td><td></td><td>13,632</td><td>2,524</td><td>2,932</td></tr><tr><td>Asset ceiling restrictions</td><td></td><td>-</td><td>-</td><td>(26)</td></tr><tr><td>Present value of scheme obligations</td><td></td><td>(13,299)</td><td>(3,248)</td><td>(3,644)</td></tr><tr><td>Net surplus/(obligation)</td><td></td><td>333</td><td>(724)</td><td>(738)</td></tr><tr><td>Included in Other non-current assets</td><td></td><td>606</td><td>-</td><td>135</td></tr><tr><td>Included in Pensions and other post-employment benefits</td><td></td><td>(273)</td><td>(724)</td><td>(873)</td></tr><tr><td></td><td></td><td>333</td><td>(724)</td><td>(738)</td></tr><tr><td>Actual return on plan assets</td><td></td><td>541</td><td>97</td><td>48</td></tr><tr><td></td><td></td><td></td><td></td><td>686</td></tr><tr><td>At 31 December 2020</td><td></td><td>UK
£m</td><td>US
£m</td><td>Rest of World
£m</td><td>Group
£m</td></tr><tr><td>Equities:</td><td>- listed</td><td>2,686</td><td>539</td><td>686</td></tr><tr><td></td><td>- unlisted</td><td>-</td><td>-</td><td>5</td></tr><tr><td>Multi-asset funds</td><td></td><td>2,075</td><td>-</td><td>-</td></tr><tr><td>Property:</td><td>- listed</td><td>-</td><td>-</td><td>57</td></tr><tr><td></td><td>- unlisted</td><td>447</td><td>136</td><td>2</td></tr><tr><td>Corporate bonds:</td><td>- listed</td><td>1,113</td><td>1,066</td><td>154</td></tr><tr><td></td><td>- unlisted</td><td>-</td><td>-</td><td>20</td></tr><tr><td>Government bonds:</td><td>- listed</td><td>6,055</td><td>758</td><td>999</td></tr><tr><td>Insurance contracts</td><td></td><td>1,409</td><td>-</td><td>988</td></tr><tr><td>Other (liabilities)/assets</td><td></td><td>(203)</td><td>136</td><td>78</td></tr><tr><td>Fair value of assets</td><td></td><td>13,582</td><td>2,635</td><td>2,989</td></tr><tr><td>Present value of scheme obligations</td><td></td><td>(13,858)</td><td>(3,445)</td><td>(4,007)</td></tr><tr><td>Net surplus/(obligation)</td><td></td><td>(276)</td><td>(810)</td><td>(1,018)</td></tr><tr><td>Included in Other non-current assets</td><td></td><td>77</td><td>-</td><td>106</td></tr><tr><td>Included in Pensions and other post-employment benefits</td><td></td><td>(353)</td><td>(810)</td><td>(1,124)</td></tr><tr><td></td><td></td><td>(276)</td><td>(810)</td><td>(1,018)</td></tr><tr><td>Actual return on plan assets</td><td></td><td>1,092</td><td>159</td><td>177</td></tr></table>



## Notes to the financial statements continued

## 31. Pensions and other post-employment benefits continued

<table><tr><td rowspan="2">Movements in fair values of assets</td><td colspan="2">UK</td><td colspan="2">Rest of World</td><td colspan="2">Pensions</td><td colspan="2">Post-retirement benefits</td></tr><tr><td>£m</td><td>£m</td><td>£m</td><td>£m</td><td>£m</td><td>£m</td><td>Group</td><td>Group</td></tr><tr><td>Assets at 1 January 2020</td><td>12,981</td><td>2,789</td><td>2,662</td><td>18,432</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Exchange adjustments</td><td>-</td><td>(86)</td><td>138</td><td>52</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Interest income</td><td>256</td><td>87</td><td>29</td><td>372</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Expenses</td><td>(9)</td><td>(12)</td><td>-</td><td>(21)</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Settlements and curtailments</td><td>-</td><td>-</td><td>(20)</td><td>(20)</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Remeasurement</td><td>836</td><td>72</td><td>148</td><td>1,056</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Employer contributions</td><td>156</td><td>33</td><td>124</td><td>313</td><td>105</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Scheme participants&#x27; contributions</td><td>3</td><td>-</td><td>18</td><td>21</td><td>18</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Benefits paid</td><td>(641)</td><td>(248)</td><td>(110)</td><td>(999)</td><td>(123)</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Assets at 31 December 2020</td><td>13,582</td><td>2,635</td><td>2,989</td><td>19,206</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Exchange adjustments</td><td>-</td><td>31</td><td>(184)</td><td>(153)</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Interest income</td><td>187</td><td>57</td><td>18</td><td>262</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Expenses</td><td>(15)</td><td>(12)</td><td>-</td><td>(27)</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Settlements and curtailments</td><td>-</td><td>-</td><td>(7)</td><td>(7)</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Remeasurement</td><td>354</td><td>40</td><td>30</td><td>424</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Employer contributions</td><td>139</td><td>40</td><td>133</td><td>312</td><td>105</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Scheme participants&#x27; contributions</td><td>3</td><td>-</td><td>24</td><td>27</td><td>15</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Benefits paid</td><td>(618)</td><td>(267)</td><td>(97)</td><td>(982)</td><td>(120)</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Assets at 31 December 2021</td><td>13,632</td><td>2,524</td><td>2,906</td><td>19,062</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Exchange adjustments</td><td>-</td><td>286</td><td>122</td><td>408</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Interest income</td><td>271</td><td>71</td><td>28</td><td>370</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Expenses</td><td>(14)</td><td>(21)</td><td>-</td><td>(35)</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Settlements and curtailments</td><td>-</td><td>-</td><td>(8)</td><td>(8)</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Remeasurement</td><td>(4,981)</td><td>(324)</td><td>(578)</td><td>(5,883)</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Employer contributions</td><td>755</td><td>50</td><td>114</td><td>919</td><td>117</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Scheme participants&#x27; contributions</td><td>-</td><td>-</td><td>15</td><td>15</td><td>18</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Transfer to assets held for sale/distribution</td><td>-</td><td>-</td><td>(624)</td><td>(624)</td><td>-</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Benefits paid</td><td>(649)</td><td>(326)</td><td>(105)</td><td>(1,080)</td><td>(135)</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Assets at 31 December 2022</td><td>9,014</td><td>2,260</td><td>1,870</td><td>13,144</td><td>-</td><td>-</td><td>-</td><td>-</td></tr></table>

In connection with the demerger of Consumer Healthcare, the 31 December 2020 pension scheme valuations identified cash funding or technical provisions deficits in three GSK UK Pension Schemes.

During March 2022, GSK transferred 7,004 GSK Consumer Healthcare Holdings Limited (GSKCHH) C Ordinary Shares (representing 11.03%. (in aggregate) of GSK's interest in GSKCHH to three Scottish Limited Partnerships ("SLPs"), each providing a funding mechanism for a separate GSK UK defined benefit pension scheme. As part of the steps relating to the demerger and separation, the SLPs transferred their applicable portion of GSKCHH C Ordinary Shares to Haleon plc ("Haleon") in consideration for shares in Haleon. The SLPs together hold shares representing 7.5% of the total issued share capital of Haleon.

Each pension scheme, through its SLP interest, is entitled to receive a distribution from that SLP in an amount equal to the net proceeds of sales of Haleon shares, and to receive dividend income on the Haleon shares until it has received an aggregate amount equal to an agreed threshold ("Proceeds Threshold"). The Proceeds Thresholds total £1,080 million (as increased by notional interest on the remaining balance from time to time), and payment of this amount would fully fund the cash funding or "technical provisions" deficits in the three pension schemes shown by the 31 December 2020 valuations. Once the applicable Proceeds Threshold has been reached the GSK-controlled General Partner of each SLP is entitled to sell the remaining Haleon shares held by the SLP and distribute the proceeds to GSK. If a pension scheme does not receive aggregate cash equal to the applicable Proceeds Threshold within 18 months after separation, then the trustee of that pension scheme will have the ability to require the SLP to instruct a broker to liquidate any remaining Haleon shares on behalf of the SLP in accordance with an agreed mandate.

During 2022, the Group made additional funding contributions to the UK pension schemes of £691 million (2021: £44 million; 2020: £76 million) but no additional funding (2021: £nil; 2020: £nil) to the US schemes.

As at 31 December 2022, total cash contributions totalling £735 million were made towards the Proceeds Thresholds leaving a principal amount of £345 million outstanding to the UK pension schemes. The cash contributions of £735 million include voluntary cash contributions made by GSK in Q4 2022 to two of the UK defined benefit pension schemes totalling £334 million in response to the market volatility in the UK gilt markets.



## Notes to the financial statements continued

## 31. Pensions and other post-employment benefits continued

The outstanding accelerated contributions were collateralised by the creation of three Scottish Limited Partnerships (SLPs), into which GSK inserted a total of 692,593,037 Haleon ordinary shares across the three SLPs. Each of the three principal UK defined benefit pension schemes (two benefiting current and former Glaxo Welcome employees, with the third benefiting current and former SmithKline Beecham employees) has an interest in one of the SLPs as shown below:

<table><tr><td>Scottish Limited Partnership</td><td>General Partner</td><td>Limited Partners</td><td></td></tr><tr><td>GSK (No. 1) Scottish Limited Partnership</td><td>GSK GPI Ltd</td><td>GSK LP Ltd</td><td>Berkeley Square Pension Trustee Company Ltd acting on behalf of the GSK Pension Scheme</td></tr><tr><td>GSK (No. 2) Scottish Limited Partnership</td><td>GSK GPI Ltd</td><td>GSK LP Ltd</td><td>Berkeley Square Pension Trustee Company Ltd acting on behalf of the GSK Pension Fund</td></tr><tr><td>GSK (No. 3) Scottish Limited Partnership</td><td>GSK GP2 Ltd</td><td>GSK LP Ltd</td><td>SmithKline Beecham Pension Plan Trustee Ltd acting on behalf of the SmithKline Beecham Pension Plan</td></tr></table>

Under each of the SLP partnership agreements, the limited partners have no involvement in the management of the business and shall not take any part in the control of SLP. The general partner (in all cases, controlled by GSK plc) is responsible for the management and control of each SLP and, as such, each SLP is consolidated into the results of the Group. Each SLP therefore takes advantage of the exemption in Regulation 7 of The Partnership (Accounts) Regulations 2008 Act to not prepare and deliver audited accounts to the UK registrar.

Under the SLP partnership agreement, distributions will be made from partnership income to the defined benefit pension schemes if equivalent payments have not already been made to the three defined benefit pension schemes by another GSK entity. To date, £735 million has been paid to the defined benefit pension schemes by GSK under this structure and once contributions under this structure reach £1,080 million, the defined benefit pension schemes interests' in the SLPs ends. The remaining economic interest in the SLPs will be held by GSK LP Ltd, a 100% owned subsidiary of GSK plc. At 31 December 2022, £345 million of these additional contributions remains to be paid.

Employer contributions for 2023, excluding special funding contributions stated above, are estimated to be approximately £350 million in respect of defined benefit pension schemes and £100 million in respect of post-retirement benefits.

<table><tr><td rowspan="2">Movements in defined benefit obligations</td><td colspan="5">Post-retirement</td></tr><tr><td>UK
£m</td><td>US
£m</td><td>Rest of World
£m</td><td>Group
£m</td><td>Group
£m</td></tr><tr><td>Obligations at 1 January 2020</td><td>(13,293)</td><td>(3,506)</td><td>(3,554)</td><td>(20,353)</td><td>(1,418)</td></tr><tr><td>Exchange adjustments</td><td>-</td><td>118</td><td>(188)</td><td>(70)</td><td>36</td></tr><tr><td>Disposals</td><td>-</td><td>-</td><td>-</td><td>-</td><td>9</td></tr><tr><td>Service cost</td><td>(61)</td><td>(83)</td><td>(147)</td><td>(291)</td><td>(36)</td></tr><tr><td>Past service cost</td><td>(98)</td><td>56</td><td>(1)</td><td>(43)</td><td>55</td></tr><tr><td>Interest cost</td><td>(259)</td><td>(110)</td><td>(39)</td><td>(408)</td><td>(39)</td></tr><tr><td>Settlements and curtailments</td><td>-</td><td>-</td><td>38</td><td>38</td><td>7</td></tr><tr><td>Remeasurement</td><td>(785)</td><td>(168)</td><td>(208)</td><td>(1,161)</td><td>(82)</td></tr><tr><td>Scheme participants&#x27; contributions</td><td>(3)</td><td>-</td><td>(18)</td><td>(21)</td><td>(18)</td></tr><tr><td>Benefits paid</td><td>641</td><td>248</td><td>110</td><td>999</td><td>123</td></tr><tr><td>Obligations at 31 December 2020</td><td>(13,858)</td><td>(3,445)</td><td>(4,007)</td><td>(21,310)</td><td>(1,363)</td></tr><tr><td>Exchange adjustments</td><td>-</td><td>(40)</td><td>258</td><td>218</td><td>4</td></tr><tr><td>Service cost</td><td>(56)</td><td>(9)</td><td>(151)</td><td>(216)</td><td>(29)</td></tr><tr><td>Past service cost</td><td>(28)</td><td>(2)</td><td>25</td><td>(5)</td><td>(12)</td></tr><tr><td>Interest cost</td><td>(190)</td><td>(76)</td><td>(23)</td><td>(289)</td><td>(26)</td></tr><tr><td>Settlements and curtailments</td><td>-</td><td>-</td><td>17</td><td>17</td><td>-</td></tr><tr><td>Remeasurement</td><td>218</td><td>57</td><td>164</td><td>439</td><td>78</td></tr><tr><td>Scheme participants&#x27; contributions</td><td>(3)</td><td>-</td><td>(24)</td><td>(27)</td><td>(15)</td></tr><tr><td>Benefits paid</td><td>618</td><td>267</td><td>97</td><td>982</td><td>120</td></tr><tr><td>Obligations at 31 December 2021</td><td>(13,299)</td><td>(3,248)</td><td>(3,644)</td><td>(20,191)</td><td>(1,243)</td></tr><tr><td>Exchange adjustments</td><td>-</td><td>(371)</td><td>(124)</td><td>(495)</td><td>(125)</td></tr><tr><td>Service cost</td><td>(13)</td><td>(7)</td><td>(126)</td><td>(146)</td><td>(22)</td></tr><tr><td>Past service cost</td><td>(6)</td><td>-</td><td>-</td><td>(6)</td><td>-</td></tr><tr><td>Interest cost</td><td>(260)</td><td>(91)</td><td>(37)</td><td>(388)</td><td>(32)</td></tr><tr><td>Settlements and curtailments</td><td>-</td><td>-</td><td>29</td><td>29</td><td>-</td></tr><tr><td>Remeasurement</td><td>3,812</td><td>360</td><td>839</td><td>5,011</td><td>228</td></tr><tr><td>Scheme participants&#x27; contributions</td><td>-</td><td>-</td><td>(15)</td><td>(15)</td><td>(18)</td></tr><tr><td>Transfer to assets held for sale/distribution</td><td>-</td><td>-</td><td>621</td><td>621</td><td>83</td></tr><tr><td>Benefits paid</td><td>649</td><td>326</td><td>105</td><td>1,080</td><td>135</td></tr><tr><td>Obligations at 31 December 2022</td><td>(9,117)</td><td>(3,031)</td><td>(2,352)</td><td>(14,500)</td><td>(994)</td></tr></table>



## Notes to the financial statements continued

## 31. Pensions and other post-employment benefits continued

The defined benefit pension obligation is analysed as follows:

<table><tr><td></td><td>2022
£m</td><td>2021
£m</td><td>2020
£m</td></tr><tr><td>Funded</td><td>(13,887)</td><td>(19,419)</td><td>(20,504)</td></tr><tr><td>Unfunded</td><td>(613)</td><td>(772)</td><td>(806)</td></tr><tr><td></td><td>(14,500)</td><td>(20,191)</td><td>(21,310)</td></tr></table>

The liability for the US post-retirement healthcare scheme has been assessed using the same assumptions as for the US pension scheme, together with the assumption for future medical inflation of 7% (2021: 6.25%) in 2022, grading down to 5% in 2031 and thereafter. At 31 December 2022, the US post-retirement healthcare scheme obligation was £870 million (2021: £1,059 million; 2020: £1,124 million). Post-retirement benefits are unfunded.

The movement in the net defined benefit liability is as follows:

<table><tr><td></td><td>2022
£m</td><td>2021
£m</td><td>2020
£m</td></tr><tr><td>At 1 January</td><td>(1,129)</td><td>(2,104)</td><td>(1,921)</td></tr><tr><td>Exchange adjustments</td><td>(87)</td><td>65</td><td>(18)</td></tr><tr><td>Service cost</td><td>(146)</td><td>(216)</td><td>(291)</td></tr><tr><td>Past service cost</td><td>(6)</td><td>(5)</td><td>(43)</td></tr><tr><td>Interest cost</td><td>(18)</td><td>(27)</td><td>(36)</td></tr><tr><td>Settlements and curtailments</td><td>21</td><td>10</td><td>18</td></tr><tr><td>Remeasurements:</td><td></td><td></td><td></td></tr><tr><td>Return on plan assets, excluding amounts included in interest</td><td>(5,883)</td><td>424</td><td>1,056</td></tr><tr><td>(Loss)/gain from change in demographic assumptions</td><td>92</td><td>(62)</td><td>69</td></tr><tr><td>Gain/(loss) from change in financial assumptions</td><td>5,868</td><td>716</td><td>(1,340)</td></tr><tr><td>Experience (loss)/gain</td><td>(949)</td><td>(215)</td><td>110</td></tr><tr><td>Employer contributions</td><td>919</td><td>312</td><td>313</td></tr><tr><td>Transfer to assets held for sale/distribution</td><td>(3)</td><td>-</td><td>-</td></tr><tr><td>Expenses</td><td>(35)</td><td>(27)</td><td>(21)</td></tr><tr><td>At 31 December</td><td>(1,356)</td><td>(1,129)</td><td>(2,104)</td></tr></table>

The remeasurements included within post-retirement benefits are detailed below:

<table><tr><td></td><td>2022
£m</td><td>2021
£m</td><td>2020
£m</td></tr><tr><td>Gain from change in demographic assumptions</td><td>21</td><td>19</td><td>7</td></tr><tr><td>Gain/(loss) from change in financial assumptions</td><td>219</td><td>35</td><td>(93)</td></tr><tr><td>Experience gains</td><td>(12)</td><td>24</td><td>4</td></tr><tr><td></td><td>228</td><td>78</td><td>(82)</td></tr></table>

The defined benefit pension obligation analysed by membership category is as follows:

<table><tr><td></td><td>2022
£m</td><td>2021(1)£m</td><td>2020(1)£m</td></tr><tr><td>Active</td><td>1,390</td><td>4,196</td><td>4,660</td></tr><tr><td>Retired</td><td>8,540</td><td>11,115</td><td>11,257</td></tr><tr><td>Deferred</td><td>4,570</td><td>4,880</td><td>5,393</td></tr><tr><td></td><td>14,500</td><td>20,191</td><td>21,310</td></tr></table>

The post-retirement benefit obligation analysed by membership category is as follows:

<table><tr><td></td><td>2022
£m</td><td>2021(1)£m</td><td>2020(1)£m</td></tr><tr><td>Active</td><td>306</td><td>494</td><td>551</td></tr><tr><td>Retired</td><td>688</td><td>748</td><td>808</td></tr><tr><td>Deferred</td><td>-</td><td>1</td><td>4</td></tr><tr><td></td><td>994</td><td>1,243</td><td>1,363</td></tr></table>

The weighted average duration of the defined benefit obligation is as follows:

<table><tr><td></td><td>2022 years</td><td>2021 years</td><td>2020 years</td></tr><tr><td>Pension benefits</td><td>12</td><td>15</td><td>16</td></tr><tr><td>Post-retirement benefits</td><td>10</td><td>12</td><td>12</td></tr></table>

(1) Membership numbers are not restated as the disclosure relates to the post-retirement benefit obligations.



## Notes to the financial statements continued

## 31. Pensions and other post-employment benefits continued

## Sensitivity analysis

The effect of changes in assumptions used on the benefit obligations and on the 2023 annual defined benefit pension and post-retirement costs are detailed below. This information has been determined by taking into account the duration of the liabilities and the overall profile of the plan memberships.

<table><tr><td></td><td>0.25% increase £m</td><td>0.25% decrease £m</td></tr><tr><td>Discount rate</td><td></td><td></td></tr><tr><td>(Decrease)/increase in annual pension cost</td><td>(19)</td><td>19</td></tr><tr><td>Increase/(decrease) in annual post-retirement benefits cost</td><td>1</td><td>(1)</td></tr><tr><td>(Decrease)/increase in pension obligation</td><td>(400)</td><td>424</td></tr><tr><td>(Decrease)/increase in post-retirement benefits obligation</td><td>(21)</td><td>21</td></tr><tr><td></td><td>0.75% increase £m</td><td>0.75% decrease £m</td></tr><tr><td>(Decrease)/increase in annual pension cost</td><td>(60)</td><td>52</td></tr><tr><td>Increase/(decrease) in annual post-retirement benefits cost</td><td>2</td><td>(3)</td></tr><tr><td>(Decrease)/increase in pension obligation</td><td>(1147)</td><td>1,341</td></tr><tr><td>(Decrease)/increase in post-retirement benefits obligation</td><td>(61)</td><td>70</td></tr><tr><td></td><td>0.25% increase £m</td><td>0.25% decrease £m</td></tr><tr><td>Inflation rate</td><td></td><td></td></tr><tr><td>Increase/(decrease) in annual pension cost</td><td>17</td><td>(15)</td></tr><tr><td>Increase/(decrease) in pension obligation</td><td>301</td><td>(290)</td></tr><tr><td></td><td>0.75% increase £m</td><td>0.75% decrease £m</td></tr><tr><td>Increase/(decrease) in annual pension cost</td><td>50</td><td>(43)</td></tr><tr><td>Increase/(decrease) in pension obligation</td><td>945</td><td>(827)</td></tr><tr><td></td><td>1 year increase £m</td><td></td></tr><tr><td>Life expectancy</td><td></td><td></td></tr><tr><td>Increase in annual pension cost</td><td>22</td><td></td></tr><tr><td>Increase in annual post-retirement benefits cost</td><td>2</td><td></td></tr><tr><td>Increase in pension obligation</td><td>432</td><td></td></tr><tr><td>Increase in post-retirement benefits obligation</td><td>34</td><td></td></tr><tr><td></td><td>1% increase £m</td><td></td></tr><tr><td>Rate of future healthcare inflation</td><td></td><td></td></tr><tr><td>Increase in annual post-retirement benefits cost</td><td>1</td><td></td></tr><tr><td>Increase in post-retirement benefits obligation</td><td>25</td><td></td></tr></table>



## 32. Other provisions

<table><tr><td></td><td>Legal and other disputes £m</td><td>Major restructuring programmes £m</td><td>Employee related provisions £m</td><td>Other provisions £m</td><td>Total £m</td></tr><tr><td>At 1 January 2022</td><td>196</td><td>652</td><td>322</td><td>301</td><td>1,471</td></tr><tr><td>Exchange adjustments</td><td>28</td><td>21</td><td>16</td><td>20</td><td>85</td></tr><tr><td>Charge for the year</td><td>145</td><td>144</td><td>125</td><td>141</td><td>555</td></tr><tr><td>Reversed unused</td><td>(12)</td><td>(131)</td><td>(40)</td><td>(78)</td><td>(261)</td></tr><tr><td>Unwinding of discount</td><td>3</td><td>1</td><td>-</td><td>-</td><td>4</td></tr><tr><td>Utilised</td><td>(126)</td><td>(277)</td><td>(91)</td><td>(45)</td><td>(539)</td></tr><tr><td>Transfer to assets held for sale/distribution</td><td>(16)</td><td>(60)</td><td>(22)</td><td>(21)</td><td>(119)</td></tr><tr><td>Additions through business combinations</td><td>-</td><td>15</td><td>-</td><td>8</td><td>23</td></tr><tr><td>Reclassifications and other movements</td><td>-</td><td>(8)</td><td>(1)</td><td>(20)</td><td>(29)</td></tr><tr><td>Transfer to Pension obligations</td><td>-</td><td>(6)</td><td>-</td><td>-</td><td>(6)</td></tr><tr><td>At 31 December 2022</td><td>218</td><td>351</td><td>309</td><td>306</td><td>1,184</td></tr><tr><td>To be settled within one year</td><td>190</td><td>259</td><td>75</td><td>128</td><td>652</td></tr><tr><td>To be settled after one year</td><td>28</td><td>92</td><td>234</td><td>178</td><td>532</td></tr><tr><td>At 31 December 2022</td><td>218</td><td>351</td><td>309</td><td>306</td><td>1,184</td></tr></table>

## Legal and other disputes

The Group is involved in a substantial number of legal and other disputes, including notification of possible claims, as set out in Note 47, 'Legal proceedings'. Provisions for legal and other disputes include amounts relating to product liability, anti-trust, government investigations, contract terminations and self insurance.

The Group may become involved in significant legal proceedings in respect of which it is not possible to meaningfully assess whether the outcome will result in a probable outflow, or to quantify or reliably estimate the liability, if any, that could result from ultimate resolution of the proceedings. In these cases, the Group would provide appropriate disclosures about such cases, but no provision would be made.

The net charge for the year of £133 million (including reversals and estimated insurance recoveries) primarily related to provisions for product liability cases, commercial disputes and various other government investigations.

The discount on the provision is £3 million in 2022 (2021: £nil). The discount was calculated using risk-adjusted projected cash flows and risk-free rates of return.

In respect of product liability claims related to certain products, provision is made when there is sufficient history of claims made and settlements to enable management to make a reliable estimate of the provision required to cover unasserted claims. The ultimate liability for such matters may vary from the amounts provided and is dependent upon the outcome of litigation proceedings, investigations and possible settlement negotiations.

The Group’s position could change over time, and, therefore, there can be no assurance that any losses that result from the outcome of any legal proceedings will not exceed by a material amount the amount of the provisions reported in the Group’s financial accounts.
It is in the nature of the Group’s business that a number of these matters may be the subject of negotiation and litigation over many years. Litigation proceedings, including the various appeal procedures, often take many years to reach resolution, and out-of-court settlement discussions can also often be protracted. Indemnified disputes will result in a provision charge and a corresponding receivable.

The Group is in potential settlement discussions in a number of the disputes for which amounts have been provided and, based on its current assessment of the progress of these disputes, estimates that £190 million of the amount provided at 31 December 2022 will be settled within one year. At 31 December 2022, it was expected that £nil (2021: £4 million) of the provision made for legal and other disputes will be reimbursed by third parties. For a discussion of legal issues, See Note 47, 'Legal proceedings'.

## Major restructuring programmes

During 2022, the Group had two major restructuring programmes in progress: the Separation Preparation programme which focused on preparing for the separation of GSK into two new companies and the Significant Acquisitions programme which is focused on the integration of recent acquisitions.

Restructuring provisions primarily include severance costs when management has made a formal decision to eliminate certain positions and this has been communicated to the groups of employees affected and appropriate consultation procedures completed, where appropriate. No provision is made for staff severance payments that are paid immediately.

The discount on the provisions increased by £1 million in 2022 (2021: increased by £2 million).

Pension augmentation includes £6 million relating to the defined benefit plan arising from staff redundancies, as shown in Note 30, 'Pensions and other post-employment benefits'.



## Notes to the financial statements continued

## Employee related provisions

Employee related provisions include obligations for certain medical benefits to disabled employees and their spouses in the US.

At 31 December 2022, the provision for these benefits amounted to £66 million (2021: £69 million). Other employee benefits reflect a variety of provisions for severance costs, jubilee awards and other long-service benefits. Given the nature of these provisions, the amounts are likely to be settled over many years.

## Other provisions

Included in other provisions are provisions for onerous contracts, insurance provisions and a number of other provisions including vehicle insurance and regulatory matters.



## 33. Contingent consideration liabilities

The consideration for certain acquisitions includes amounts contingent on future events such as development milestones or sales performance. The Group has provided for the fair value of this contingent consideration as follows:

<table><tr><td rowspan="2"></td><td colspan="2">Shionogi-ViiV Healthcare</td><td colspan="2">Novartis Vaccines</td><td rowspan="2">Other</td><td rowspan="2">Total</td></tr><tr><td>Affinvex</td><td>Affinvex</td><td>Affinvex</td><td>Affinvex</td></tr><tr><td>At 1 January 2020</td><td>5,103</td><td>-</td><td>339</td><td>37</td><td>5,479</td><td></td></tr><tr><td>Remeasurement through income statement</td><td>1,114</td><td>-</td><td>161</td><td>-</td><td>1,275</td><td></td></tr><tr><td>Cash payments: operating cash flows</td><td>(751)</td><td>-</td><td>(14)</td><td>-</td><td>(765)</td><td></td></tr><tr><td>Cash payments: investing activities</td><td>(107)</td><td>-</td><td>(9)</td><td>(4)</td><td>(120)</td><td></td></tr><tr><td>At 31 December 2021</td><td>5,359</td><td>-</td><td>477</td><td>33</td><td>5,869</td><td></td></tr><tr><td>Remeasurement through income statement</td><td>1,026</td><td>-</td><td>32</td><td>5</td><td>1,063</td><td></td></tr><tr><td>Cash payments: operating cash flows</td><td>(721)</td><td>-</td><td>(21)</td><td>-</td><td>(742)</td><td></td></tr><tr><td>Cash payments: investing activities</td><td>(105)</td><td>-</td><td>(9)</td><td>-</td><td>(114)</td><td></td></tr><tr><td>At 31 December 2021</td><td>5,559</td><td>-</td><td>479</td><td>38</td><td>6,076</td><td></td></tr><tr><td>Remeasurement through income statement</td><td>1,431</td><td>17</td><td>231</td><td>(34)</td><td>1,645</td><td></td></tr><tr><td>Exchange movement through reserves</td><td>-</td><td>2</td><td>-</td><td>-</td><td>2</td><td></td></tr><tr><td>Initial recognition from business combinations</td><td>-</td><td>482</td><td>-</td><td>-</td><td>482</td><td></td></tr><tr><td>Cash payments: operating cash flows</td><td>(1,031)</td><td>-</td><td>(27)</td><td>-</td><td>(1,058)</td><td></td></tr><tr><td>Cash payments: investing activities</td><td>(69)</td><td>-</td><td>(10)</td><td>-</td><td>(79)</td><td></td></tr><tr><td>At 31 December 2022</td><td>5,890</td><td>501</td><td>673</td><td>4</td><td>7,068</td><td></td></tr></table>

Of the contingent consideration payable at 31 December 2022, £1,289 million (2021: £958 million) is expected to be paid within one year.

The consideration payable for the acquisition of the Shionogi-ViiV Healthcare joint venture, Affinvex and the Novartis Vaccines business are expected to be paid over a number of years. As a result, the total estimated liabilities are discounted to their present values, shown above. The Shionogi-ViiV Healthcare contingent consideration liability is discounted at 8% (2021: 8%), the Affinvex contingent consideration liability is discounted at 9.9% and the Novartis Vaccines contingent consideration liability is discounted at 7.5% (2021: 7.5%) for commercialised products and at 8.5% (2021: 8.5%) for pipeline assets.

The Shionogi-ViiV Healthcare and Novartis Vaccines contingent consideration liabilities are calculated principally based on the forecast sales performance of specified products over the lives of those products.

The Affinvex contingent consideration is based upon two potential milestone payments, each of $0.6 billion (£0.5 billion) which will be paid if certain pediatric clinical development milestones are achieved.

The table below shows on an indicative basis the income statement and balance sheet sensitivity to reasonably possible changes in key inputs to the valuations of the contingent consideration liabilities.

<table><tr><td rowspan="2">Increase/(decrease) in financial liability and loss/(gain) in Income statement</td><td colspan="2">2022</td><td colspan="2">2021</td></tr><tr><td>Shionogi-ViiV Healthcare</td><td>Affinvex</td><td>Novartis Vaccines</td><td>Novartis Vaccines</td></tr><tr><td>10% increase in sales forecasts*</td><td>556</td><td>n/a</td><td>103</td><td>506</td></tr><tr><td>15% increase in sales forecasts*</td><td>834</td><td>n/a</td><td>154</td><td>759</td></tr><tr><td>10% decrease in sales forecasts*</td><td>(555)</td><td>n/a</td><td>(103)</td><td>(506)</td></tr><tr><td>15% decrease in sales forecasts*</td><td>(833)</td><td>n/a</td><td>(153)</td><td>(759)</td></tr><tr><td>1% increase in discount rate</td><td>(199)</td><td>(7)</td><td>(55)</td><td>(198)</td></tr><tr><td>1.5% increase in discount rate</td><td>(292)</td><td>(10)</td><td>(80)</td><td>(286)</td></tr><tr><td>1% decrease in discount rate</td><td>214</td><td>7</td><td>65</td><td>213</td></tr><tr><td>1.5% decrease in discount rate</td><td>328</td><td>11</td><td>101</td><td>319</td></tr><tr><td>10 cent appreciation of US Dollar</td><td>411</td><td>45</td><td>22</td><td>343</td></tr><tr><td>15 cent appreciation of US Dollar</td><td>645</td><td>71</td><td>36</td><td>495</td></tr><tr><td>10 cent depreciation of US Dollar</td><td>(347)</td><td>(38)</td><td>(19)</td><td>(299)</td></tr><tr><td>15 cent depreciation of US Dollar</td><td>(501)</td><td>(56)</td><td>(27)</td><td>(398)</td></tr><tr><td>10 cent appreciation of Euro</td><td>109</td><td>n/a</td><td>23</td><td>102</td></tr><tr><td>15 cent appreciation of Euro</td><td>171</td><td>n/a</td><td>36</td><td>160</td></tr><tr><td>10 cent depreciation of Euro</td><td>(91)</td><td>n/a</td><td>(19)</td><td>(85)</td></tr><tr><td>15 cent depreciation of Euro</td><td>(130)</td><td>n/a</td><td>(28)</td><td>(124)</td></tr><tr><td>10% increase in probability of milestone success</td><td>n/a</td><td>82</td><td>20</td><td>n/a</td></tr><tr><td>10% decrease in probability of milestone success</td><td>n/a</td><td>(82)</td><td>(10)</td><td>n/a</td></tr></table>

* The sales forecast is for ViiV Healthcare sales only in respect of the Shionogi-ViiV Healthcare contingent consideration.

An explanation of the accounting for ViiV Healthcare is set out on page 71.



## 34. Other non-current liabilities

<table><tr><td></td><td>2022</td><td>2021</td></tr><tr><td></td><td>£m</td><td>£m</td></tr><tr><td>Accruals</td><td>11</td><td>13</td></tr><tr><td>Deferred income</td><td>83</td><td>85</td></tr><tr><td>Other payables</td><td>805</td><td>823</td></tr><tr><td></td><td>899</td><td>921</td></tr></table>

Other payables includes a number of employee-related liabilities including employee savings plans.

## 35. Contingent liabilities

At 31 December 2022, contingent liabilities where GSK has a present obligation as a result of a past event, comprising guarantees and other items arising in the normal course of business, amounted to £58 million (2021: £126 million). At 31 December 2022, £0.5 million (2021: £0.2 million) of financial assets were pledged as collateral for contingent liabilities. Provision is made for the outcome of tax, legal and other disputes where it is both probable that the Group will suffer an outflow of funds and it is possible to make a reliable estimate of that outflow. If it is not possible to meaningfully assess whether the outcomes will result in a probable outflow, or to quantify or reliably estimate the liability, if any, no provision is recorded. Descriptions of the significant legal and other disputes to which the Group is a party are set out in Note 47, 'Legal proceedings'.

## 36. Commitments

<table><tr><td>Contractual obligations and commitments</td><td>2022</td><td>2021</td></tr><tr><td></td><td>£m</td><td>£m</td></tr><tr><td>Contracted for but not provided in the financial statements:</td><td></td><td></td></tr><tr><td>Intangible assets</td><td>10,659</td><td>12,082</td></tr><tr><td>Property, plant and equipment</td><td>743</td><td>616</td></tr><tr><td>Investments</td><td>138</td><td>146</td></tr><tr><td>Purchase commitments</td><td>161</td><td>484</td></tr><tr><td>Pensions and post-retirement benefits</td><td>345</td><td>44</td></tr><tr><td>Interest on loans</td><td>6,322</td><td>7,603</td></tr><tr><td>Future finance charges on leases</td><td>146</td><td>153</td></tr><tr><td>Lease contracts that have not yet commenced</td><td>395</td><td>60</td></tr><tr><td></td><td>18,909</td><td>21,188</td></tr></table>

The commitments related to intangible assets include milestone payments, which are dependent on successful clinical development or on meeting specified sales targets, and which represent the maximum that would be paid if all milestones, however unlikely, are achieved. The amounts are not risk-adjusted or discounted. The net decrease in intangible asset commitments in 2022 is mainly attributable to the termination of certain agreements, offset by a number of new R&D collaborations including collaborations with Spero Therapeutics, Inc., Wuxi Biologics Ireland Limited, SpringWorks Therapeutics, Inc. and Arrowhead Pharmaceuticals, Inc.

In 2022, GSK reached an agreement with the trustees of the UK pension schemes to make additional contributions of £1,080 million, to eliminate the pension deficit identified at the 31 December 2020 actuarial funding valuation. Prior to the Consumer Healthcare demerger, GSK agreed to collateralise this commitment and accelerate funding with additional contributions (see Note 31). At 31 December 2022, £345 million of these additional contributions remained unpaid.

The Group also has other commitments which principally relate to revenue payments to be made under licences and other alliances.

Commitments in respect of future interest payable on loans are disclosed before taking into account the effect of interest rate swaps.



## 37. Share capital and share premium account

## Share Consolidation

Following completion of the Consumer Healthcare business demerger on 18 July 2022, GSK plc Ordinary shares were consolidated to maintain share price comparability before and after demerger. The consolidation was approved by GSK shareholders at a General Meeting held on 6 July 2022. Shareholders received 4 new Ordinary shares with a nominal value of 31 \( ^{1} \) /4 pence each for every 5 existing Ordinary share which had a nominal value of 25 pence each. Earnings per share, diluted earnings per share, adjusted earnings per share and dividends per share were retrospectively adjusted to reflect the Share Consolidation in all the periods presented.

<table><tr><td rowspan="2"></td><td colspan="2">Ordinary shares of 25p each pre-share consolidation</td><td rowspan="2">Share premium</td></tr><tr><td>Ordinary shares of 31 \( ^{1} \) /4p each post-share consolidation</td><td>Number</td></tr><tr><td>Share capital issued and fully paid:</td><td></td><td></td><td></td></tr><tr><td>At 1 January 2020</td><td>5,383,102,231</td><td>1,346</td><td>3,174</td></tr><tr><td>Issued under employee share schemes</td><td>2,087,386</td><td>-</td><td>29</td></tr><tr><td>Ordinary shares acquired by ESOP Trusts</td><td>-</td><td>-</td><td>78</td></tr><tr><td>At 31 December 2020</td><td>5,385,189,617</td><td>1,346</td><td>3,281</td></tr><tr><td>Issued under employee share schemes</td><td>1,825,442</td><td>1</td><td>20</td></tr><tr><td>Ordinary shares acquired by ESOP Trusts</td><td>-</td><td>-</td><td>-</td></tr><tr><td>At 31 December 2021</td><td>5,387,015,059</td><td>1,347</td><td>3,301</td></tr><tr><td>Impact of share consolidation</td><td>(1,077,403,011)</td><td>-</td><td>-</td></tr><tr><td>Issued under employee share schemes</td><td>1,731,293</td><td>-</td><td>25</td></tr><tr><td>Ordinary shares acquired by ESOP Trusts</td><td>-</td><td>-</td><td>114</td></tr><tr><td>At 31 December 2022</td><td>4,311,343,341</td><td>1,347</td><td>3,440</td></tr></table>

At 31 December 2022, of the issued share capital, 59,878,735 shares were held in the ESOP Trusts, 217,124,760 shares were held as Treasury shares and 4,034,339,846 shares were in free issue. All issued shares are fully paid and there are no shares authorised but not in issue. The nominal, carrying and market values of the shares held in the ESOP Trusts are disclosed in Note 45, 'Employee share schemes'.

## 38. Movements in equity

Retained earnings and other reserves amounted to £5,811 million at 31 December 2022 (2021: £10,407 million; 2020: £9,960 million) of which £463 million (2021: £476 million; 2020: £440 million) related to associates and joint ventures.

The cumulative translation exchange in equity is as follows:

<table><tr><td rowspan="2"></td><td colspan="4">Net translation exchange included in:</td></tr><tr><td>Retained earnings £m</td><td>Fair value reserve £m</td><td>Non-controlling interests £m</td><td>Total translation exchange £m</td></tr><tr><td>At 1 January 2020</td><td>(524)</td><td>(1)</td><td>(127)</td><td>(652)</td></tr><tr><td>Exchange movements on overseas net assets and net investment hedges</td><td>(51)</td><td>(8)</td><td>(34)</td><td>(93)</td></tr><tr><td>Reclassification of exchange movements on liquidation or disposal of overseas subsidiaries and associates</td><td>36</td><td>-</td><td>-</td><td>36</td></tr><tr><td>At 31 December 2020</td><td>(539)</td><td>(9)</td><td>(161)</td><td>(709)</td></tr><tr><td>Exchange movements on overseas net assets and net investment hedges</td><td>(239)</td><td>-</td><td>(20)</td><td>(259)</td></tr><tr><td>Reclassification of exchange movements on liquidation or disposal of overseas subsidiaries and associates</td><td>(25)</td><td>-</td><td>-</td><td>(25)</td></tr><tr><td>At 31 December 2021</td><td>(803)</td><td>(9)</td><td>(181)</td><td>(993)</td></tr><tr><td>Exchange movements on overseas net assets and net investment hedges</td><td>109</td><td>4</td><td>(28)</td><td>85</td></tr><tr><td>Reclassification of exchange movements on liquidation or disposal of overseas subsidiaries and associates</td><td>2</td><td>-</td><td>-</td><td>2</td></tr><tr><td>Movement attributable to continuing operations</td><td>(692)</td><td>(5)</td><td>(209)</td><td>(906)</td></tr><tr><td>Movement attributable to discontinued operations(6)</td><td>263</td><td>-</td><td>112</td><td>375</td></tr><tr><td>At 31 December 2022</td><td>(429)</td><td>(5)</td><td>97</td><td>(531)</td></tr></table>

(a) Includes £(554) million reclassification to the Consolidated income statement of exchange movements related to the demerger of the Consumer Healthcare business.



## Notes to the financial statements continued

## 38. Movements in equity continued

The analysis of other comprehensive income by equity category is as follows:

<table><tr><td>2022</td><td>Retained earnings £m</td><td>Other reserves £m</td><td>Non-controlling interests £m</td><td>Total £m</td></tr><tr><td>Items that may be subsequently reclassified to income statement:</td><td></td><td></td><td></td><td></td></tr><tr><td>Exchange movements on overseas net assets and net investment hedges</td><td>109</td><td>4</td><td>-</td><td>113</td></tr><tr><td>Reclassification of exchange movements on liquidation or disposal of subsidiaries and associates</td><td>2</td><td>-</td><td>-</td><td>2</td></tr><tr><td>Fair value movements on cash flow hedges</td><td>-</td><td>(18)</td><td>-</td><td>(18)</td></tr><tr><td>Tax on fair value movements on cash flow hedges</td><td>-</td><td>9</td><td>-</td><td>9</td></tr><tr><td>Reclassification of cash flow hedges to income</td><td>-</td><td>14</td><td>-</td><td>14</td></tr><tr><td>Items that will not be reclassified to income statement:</td><td></td><td></td><td></td><td></td></tr><tr><td>Exchange movements on overseas net assets of non-controlling interests</td><td>-</td><td>-</td><td>(28)</td><td>(28)</td></tr><tr><td>Fair value movements on equity investments</td><td>-</td><td>(754)</td><td>-</td><td>(754)</td></tr><tr><td>Tax on fair value movements on equity investments</td><td>-</td><td>56</td><td>-</td><td>56</td></tr><tr><td>Remeasurement on defined benefit plans</td><td>(786)</td><td>-</td><td>-</td><td>(786)</td></tr><tr><td>Tax on remeasurement defined benefit plans</td><td>211</td><td>-</td><td>-</td><td>211</td></tr><tr><td>Fair value movements on cash flow hedges</td><td>-</td><td>(6)</td><td>-</td><td>(6)</td></tr><tr><td>Other comprehensive (expense)/income for the year from continuing operations</td><td>(464)</td><td>(695)</td><td>(28)</td><td>(1,187)</td></tr><tr><td>Other comprehensive (expense)/income for the year from discontinued operations</td><td>375</td><td>(19)</td><td>-</td><td>356</td></tr><tr><td>Total other comprehensive (expense)/income for the year</td><td>(89)</td><td>(714)</td><td>(28)</td><td>(831)</td></tr></table>

<table><tr><td>2021</td><td>Retained earnings £m</td><td>Other reserves £m</td><td>Non-controlling interests £m</td><td>Total £m</td></tr><tr><td>Items that may be subsequently reclassified to income statement:</td><td></td><td></td><td></td><td></td></tr><tr><td>Exchange movements on overseas net assets and net investment hedges</td><td>(239)</td><td>-</td><td>-</td><td>(239)</td></tr><tr><td>Reclassification of exchange movements on liquidation or disposal of subsidiaries and associates</td><td>(25)</td><td>-</td><td>-</td><td>(25)</td></tr><tr><td>Fair value movements on cash flow hedges</td><td>-</td><td>5</td><td>-</td><td>5</td></tr><tr><td>Tax on fair value movements on cash flow hedges</td><td>-</td><td>(8)</td><td>-</td><td>(8)</td></tr><tr><td>Reclassification of cash flow hedges to income statement</td><td>-</td><td>12</td><td>-</td><td>12</td></tr><tr><td>Items that will not be reclassified to income statement:</td><td></td><td></td><td></td><td></td></tr><tr><td>Exchange movements on overseas net assets of non-controlling interests</td><td>-</td><td>-</td><td>(20)</td><td>(20)</td></tr><tr><td>Fair value movements on equity investments</td><td>-</td><td>(911)</td><td>-</td><td>(911)</td></tr><tr><td>Tax on fair value movements on equity investments</td><td>-</td><td>131</td><td>-</td><td>131</td></tr><tr><td>Remeasurement losses on defined benefit plans</td><td>941</td><td>-</td><td>-</td><td>941</td></tr><tr><td>Tax on remeasurement defined benefit plans</td><td>(223)</td><td>-</td><td>-</td><td>(223)</td></tr><tr><td>Other comprehensive (expense)/income for the year</td><td>454</td><td>(771)</td><td>(20)</td><td>(337)</td></tr></table>

<table><tr><td>2020</td><td>Retained earnings £m</td><td>Other reserves £m</td><td>Non-controlling interests £m</td><td>Total £m</td></tr><tr><td>Items that may be subsequently reclassified to income statement:</td><td></td><td></td><td></td><td></td></tr><tr><td>Exchange movements on overseas net assets and net investment hedges</td><td>(51)</td><td>(8)</td><td>-</td><td>(59)</td></tr><tr><td>Reclassification of exchange movements on liquidation or disposal of subsidiaries and associates</td><td>36</td><td>-</td><td>-</td><td>36</td></tr><tr><td>Fair value movements on cash flow hedges</td><td>-</td><td>(19)</td><td>-</td><td>(19)</td></tr><tr><td>Tax on fair value movements on cash flow hedges</td><td>-</td><td>(18)</td><td>-</td><td>(18)</td></tr><tr><td>Reclassification of cash flow hedges to income statement</td><td>-</td><td>54</td><td>-</td><td>54</td></tr><tr><td>Items that will not be reclassified to income statement:</td><td></td><td></td><td></td><td></td></tr><tr><td>Exchange movements on overseas net assets of non-controlling interests</td><td>-</td><td>-</td><td>(34)</td><td>(34)</td></tr><tr><td>Fair value movements on equity investments</td><td>-</td><td>1,348</td><td>-</td><td>1,348</td></tr><tr><td>Tax on fair value movements on equity investments</td><td>-</td><td>(220)</td><td>-</td><td>(220)</td></tr><tr><td>Remeasurement gains on defined benefit plans</td><td>(187)</td><td>-</td><td>-</td><td>(187)</td></tr><tr><td>Tax on remeasurement defined benefit plans</td><td>69</td><td>-</td><td>-</td><td>69</td></tr><tr><td>Other comprehensive (expense)/income for the year</td><td>(133)</td><td>1,137</td><td>(34)</td><td>970</td></tr></table>

Information on net investment hedges is provided in part (d) of Note 44 'Financial instruments and related disclosures'.



## Notes to the financial statements continued

## 38. Movements in equity continued

The analysis of other reserves is as follows:

<table><tr><td></td><td>ESOP Trust shares £m</td><td>Fair value reserve £m</td><td>Cash flow hedge reserve £m</td><td>Other reserves £m</td><td>Total £m</td></tr><tr><td>At 1 January 2020</td><td>(135)</td><td>409</td><td>(48)</td><td>2,129</td><td>2,355</td></tr><tr><td>Exchange adjustments</td><td>20</td><td>-</td><td>-</td><td>-</td><td>20</td></tr><tr><td>Transferred to retained earnings in the year on disposal of equity investments</td><td>-</td><td>(207)</td><td>-</td><td>-</td><td>(207)</td></tr><tr><td>Net fair value movement in the year</td><td>-</td><td>1,100</td><td>17</td><td>-</td><td>1,117</td></tr><tr><td>Ordinary shares acquired by ESOP Trusts</td><td>(609)</td><td>-</td><td>-</td><td>-</td><td>(609)</td></tr><tr><td>Write-down of shares held by ESOP Trusts</td><td>529</td><td>-</td><td>-</td><td>-</td><td>529</td></tr><tr><td>At 31 December 2020</td><td>(195)</td><td>1,302</td><td>(31)</td><td>2,129</td><td>3,205</td></tr><tr><td>Exchange adjustments</td><td>(1)</td><td>-</td><td>-</td><td>-</td><td>(1)</td></tr><tr><td>Transferred to income and expenses in the year on impairments of equity investments</td><td>168</td><td>-</td><td>-</td><td>-</td><td>168</td></tr><tr><td>Transferred to retained earnings in the year on disposal of equity investments</td><td>-</td><td>(139)</td><td>-</td><td>-</td><td>(139)</td></tr><tr><td>Net fair value movement in the year</td><td>-</td><td>(780)</td><td>10</td><td>-</td><td>(770)</td></tr><tr><td>At 31 December 2021</td><td>(28)</td><td>383</td><td>(21)</td><td>2,129</td><td>2,463</td></tr><tr><td>Exchange adjustments</td><td>(36)</td><td>28</td><td>12</td><td>-</td><td>4</td></tr><tr><td>Transferred to retained earnings in the year on disposal of equity investments</td><td>-</td><td>(21)</td><td>17</td><td>-</td><td>(4)</td></tr><tr><td>Balances derecognised on demerger</td><td>-</td><td>-</td><td>(169)</td><td>-</td><td>(169)</td></tr><tr><td>Net fair value movement in the year</td><td>-</td><td>(698)</td><td>141</td><td>-</td><td>(557)</td></tr><tr><td>Ordinary shares acquired by ESOP Trusts</td><td>(1,200)</td><td>-</td><td>-</td><td>-</td><td>(1,200)</td></tr><tr><td>Write-down of shares held by ESOP Trusts</td><td>911</td><td>-</td><td>-</td><td>-</td><td>911</td></tr><tr><td>At 31 December 2022</td><td>(353)</td><td>(308)</td><td>(20)</td><td>2,129</td><td>1,448</td></tr></table>

Other reserves include various non-distributable merger and pre-merger reserves amounting to £1,849 million at 31 December 2022 (2021: £1,849 million; 2020: £1,849 million). Other reserves also include the capital redemption reserve created as a result of the share buy-back programme amounting to £280 million at 31 December 2022 (2021: £280 million; 2020: £280 million).

## 39. Non-controlling interests

Total non-controlling interests includes the following individually material non-controlling interests. Other non-controlling interests are individually not material.

## ViiV Healthcare

GSK holds 78.3% of the ViiV Healthcare sub-group, giving rise to a material non-controlling interest. Summarised financial information available at the latest practicable date in respect of the ViiV Healthcare sub-group is as follows:

<table><tr><td></td><td>2022
£m</td><td>2021
£m</td><td>2020
£m</td></tr><tr><td>Turnover</td><td>5,619</td><td>4,637</td><td>4,848</td></tr><tr><td>Profit after taxation</td><td>1,528</td><td>1,087</td><td>762</td></tr><tr><td>Other comprehensive income/(expense)</td><td>94</td><td>(17)</td><td>33</td></tr><tr><td>Total comprehensive income</td><td>1,622</td><td>1,070</td><td>795</td></tr><tr><td></td><td>2022
£m</td><td>2021
£m</td><td></td></tr><tr><td>Non-current assets</td><td>2,716</td><td>2,796</td><td></td></tr><tr><td>Current assets</td><td>3,354</td><td>2,711</td><td></td></tr><tr><td>Total assets</td><td>6,070</td><td>5,507</td><td></td></tr><tr><td>Current liabilities</td><td>(3,762)</td><td>(3,121)</td><td></td></tr><tr><td>Non-current liabilities</td><td>(8,983)</td><td>(8,472)</td><td></td></tr><tr><td>Total liabilities</td><td>(12,745)</td><td>(11,593)</td><td></td></tr><tr><td>Net liabilities</td><td>(6,675)</td><td>(6,086)</td><td></td></tr><tr><td></td><td>2022
£m</td><td>2021
£m</td><td>2020
£m</td></tr><tr><td>Net cash inflow from operating activities</td><td>3,442</td><td>2,128</td><td>2,249</td></tr><tr><td>Net cash outflow from investing activities</td><td>(174)</td><td>(287)</td><td>(294)</td></tr><tr><td>Net cash outflow from financing activities</td><td>(2,718)</td><td>(1,608)</td><td>(2,483)</td></tr><tr><td>Increase/(decrease) in cash and bank overdrafts in the year</td><td>550</td><td>233</td><td>(528)</td></tr></table>



## Notes to the financial statements continued

## 39. Non-controlling interests continued

The above financial information relates to the ViiV Healthcare group on a stand-alone basis, before the impact of Group-related adjustments, primarily related to the recognition of preferential dividends. The profit after taxation of £1,528 million (2021: £1,087 million; 2020: £762 million) is stated after charging preferential dividends payable to GSK and Pfizer and after a charge of £1,483 million (2021: £1,218 million; 2020: £1,112 million) for remeasurement of contingent consideration payable. This consideration is expected to be paid over a number of years.

The following amounts attributable to the ViiV Healthcare group are included in GSK's financial statements:

<table><tr><td></td><td>2022 £m</td><td>2021 £m</td><td>2020 £m</td></tr><tr><td>Share of profit for the year attributable to non-controlling interest</td><td>415</td><td>196</td><td>223</td></tr><tr><td>Dividends paid to non-controlling interest</td><td>480</td><td>224</td><td>419</td></tr><tr><td>Non-controlling interest in the Consolidated balance sheet</td><td>(611)</td><td>(570)</td><td>(539)</td></tr></table>

## Consumer Healthcare Joint Venture

GSK held 68% of the Consumer Healthcare sub-group until the demerger on 18 July 2022 (see details in Note 4I), giving rise to a material non-controlling interest. Summarised financial information in respect of the Consumer Healthcare sub-group at 31 December 2021 is as follows:

<table><tr><td></td><td>2021 £m</td></tr><tr><td>Non-current assets</td><td>29,200</td></tr><tr><td>Current assets</td><td>5,251</td></tr><tr><td>Total assets</td><td>34,451</td></tr><tr><td>Current liabilities</td><td>(4,238)</td></tr><tr><td>Non-current liabilities</td><td>(3,733)</td></tr><tr><td>Total liabilities</td><td>(7,971)</td></tr><tr><td>Net assets</td><td>26,480</td></tr></table>

The above financial information relates to the former Consumer Healthcare Joint Venture on a stand-alone basis, before the impact of Group-related adjustments and the classification of cash pooling accounts with Group companies outside the Consumer Healthcare Joint Venture but after Major restructuring charges.

The following amounts attributable to the Consumer Healthcare Joint Venture were included in GSK's financial statements in prior years:

<table><tr><td></td><td>2021 £m</td><td>2020 £m</td></tr><tr><td>Non-controlling interest in the Consolidated balance sheet</td><td>6,609</td><td>6,538</td></tr></table>

## 40. Related party transactions

At 31 December 2022, there were no loans due to GSK from related parties (2021: £4.6 million was due from Medicxi Ventures I LP). Cash distributions were received from investment in Medicxi Ventures I LP of £6.0 million (2021: Medicxi Ventures I LP of £5.5 million, Longwood Founders Fund, LP of £3.0 million and Apollo Therapeutics LLP of £0.1 million).

As part of the joint venture agreement with Qura Therapeutics LLC, the Group has an obligation to fund the joint venture up to April 2025, with both GSK and its joint venture partner committing financial support in the amount of  $ £21.6 $  million. At December 2022, the outstanding liability due to Qura was  $ £8.3 $  million (2021:  $ £10.7 $  million).

The Group had no other significant related party transactions which might reasonably be expected to influence decisions made by the users of these Financial Statements.

The aggregate compensation of the Directors and GLT is given in Note 9, 'Employee costs'.



## 41. Acquisitions and disposals

Details of the acquisition and disposal of significant subsidiaries, associates, joint ventures and other businesses are given below:

## 2022

## Business acquisitions

On 1 July 2022, GSK completed the acquisition of 100% of Sierra Oncology, Inc., a California-based, late-stage biopharmaceutical company focused on targeted therapies for the treatment of rare forms of cancer, for $1.9 billion (£1.6 billion). The main asset is mometolinfib which targets the medical needs of myelofibrosis patients with anaemia. Total transaction costs were £52 million.

On 15 August 2022, GSK completed the acquisition of 100% of Affinivax, Inc. a clinical-stage biopharmaceutical company based in Cambridge, Boston, Massachusetts focused on pneumococcal vaccine candidates. The consideration for the acquisition comprised an upfront payment of $2.2 billion (£1.8 billion) as adjusted for working capital acquired paid upon closing and two potential milestone payments each of $0.6 billion (£0.5 billion) to be paid upon the achievement of certain paediatric clinical development milestones. The estimated fair value of the contingent consideration payable was £482 million. The values are provisional and are subject to change. The total transaction costs were £71 million.

Since acquisition, no sales arising from the Sierra Oncology or Affinivax businesses have been included in Group turnover and no revenue is expected until regulatory approval is received on the acquired assets.

GSK continues to support the ongoing development of the acquired assets and consequently these assets will be loss making until regulatory approval on these assets is received. The development of these assets has been integrated into the Group’s existing R&D activities, so it is impracticable to quantify these development costs or the impact on Total profit after taxation for the period.

Goodwill of £1,127 million (£162 million for Sierra Oncology and £965 million for Affinivax), which is not expected to be deductible for tax purposes, has been recognised. The goodwill represents workforce in place, and specific synergies available to GSK from the business combinations. The goodwill has been allocated to the Group’s Commercial Operations and R&D segments, (refer to Note 19 ‘Goodwill’ for allocation methodology).

<table><tr><td></td><td>Sierra Oncology £m</td><td>Affinivax £m</td><td>Total £m</td></tr><tr><td>Net assets acquired</td><td></td><td></td><td></td></tr><tr><td>Intangible assets</td><td>1,497</td><td>1,467</td><td>2,964</td></tr><tr><td>Property, plant and equipment</td><td>-</td><td>30</td><td>30</td></tr><tr><td>Right of use assets</td><td>1</td><td>52</td><td>53</td></tr><tr><td>Inventory</td><td>60</td><td>-</td><td>60</td></tr><tr><td>Trade and other receivables</td><td>2</td><td>17</td><td>19</td></tr><tr><td>Cash and cash equivalents</td><td>175</td><td>109</td><td>284</td></tr><tr><td>Lease liabilities</td><td>(1)</td><td>(55)</td><td>(56)</td></tr><tr><td>Trade and other payables</td><td>(40)</td><td>(77)</td><td>(117)</td></tr><tr><td>Taxation</td><td>(259)</td><td>(236)</td><td>(495)</td></tr><tr><td></td><td>1,435</td><td>1,307</td><td>2,742</td></tr><tr><td>Goodwill</td><td>162</td><td>965</td><td>1,127</td></tr><tr><td>Total</td><td>1,597</td><td>2,272</td><td>3,869</td></tr><tr><td>Total cash</td><td>1,597</td><td>1,790</td><td>3,387</td></tr><tr><td>Fair value of contingent consideration</td><td>-</td><td>482</td><td>482</td></tr></table>

On 24 November 2022 GSK signed an agreement to buy out the 25% non-controlling interest in Glaxo Saudi Arabia Ltd for SAR94 million (£21 million), to be paid in 2023.



## Notes to the financial statements continued

## 41. Acquisitions and disposals continued

## Demerger of Consumer Healthcare business

On 18 July 2022, GSK plc separated its Consumer Healthcare business from the GSK Group to form Haleon, an independent listed company. The separation was effected by way of a demerger of 80.1% of GSK's 68% holding in the Consumer Healthcare business to GSK shareholders. Following the demerger, 54.5% of Haleon was held in aggregate by GSK shareholders, 6.0% remains held by GSK (including shares received by GSK's consolidated ESOP trusts) and 7.5% remains held by certain Scottish Limited Partnerships (SLPs) set up to provide collateral for a funding mechanism pursuant to which GSK will provide additional funding for GSK's UK defined benefit pension schemes (Note 31). The aggregate ownership by GSK (including ownership by the ESOP trusts and SLPs) after the demerger of 13.5% was measured at fair value with changes through profit or loss. Pfizer continued to hold 32% of Haleon after the demerger.

Under IFRIC 17 'Distributions of Non-cash Assets to Owners' a liability and an equity distribution are measured at the fair value of the assets to be distributed when the dividend is appropriately authorised and it is no longer at the entity's discretion. The liability and equity movement, and associated gain on distribution were recognised in Q3 2022 when the demerger distribution was authorised and occurred.

The asset distributed was the 54.5% ownership of the Consumer Healthcare business. The net carrying value of the Consumer Healthcare business in the consolidated financial statements, including the retained 13.5% and net of the amount attributable to the non-controlling interest, was approximately £11.0 billion at the end of June. GSK's £6.3 billion share of the shareholder loans made in Q1 2022 in advance of the pre-separation dividends was eliminated in the consolidated financial statements. The assets distributed were reduced by Consumer Healthcare transactions up to 18 July that principally included pre-separation dividends declared and settled after the end of Q2 2022 and before 18 July 2022. Those dividends included: £10.4 billion (£7.1 billion attributable to GSK) of dividends funded by Consumer Healthcare debt that was partially on-lent during Q1 2022 and dividends of £0.6 billion (£0.4 billion attributable to GSK) from available cash balances.

The fair value of the 54.5% ownership of the Consumer Healthcare business distributed was £15.5 billion. This was measured by reference to the quoted average Haleon share price over the first five days of trading, this being a fair value measured with observable inputs which was considered to be representative of the fair value at the distribution date. A gain on distribution of this fair value less book value of the attributable net assets of the Consumer Healthcare business of £7.7 billion was recorded in the Income Statement in 2022. There was an additional gain of £2.4 billion to remeasure the retained 13.5% from its book value to fair value of £3.9 billion using the same fair value methodology as used for the distributed shares. The gain on distribution and on remeasurement of the retained stake upon demerger was presented as part of discontinued operations. Any future gains or losses on the retained stake in Haleon will be recognised in continuing operations. In addition, there was a reclassification of the Group's share of cumulative exchange differences arising on translation of the foreign currency net assets of the divested subsidiaries and offsetting net investment hedges from reserves into the Income Statement of £0.6 billion. The total gain on demerger of Consumer Healthcare was £10.1 billion. These transactions were presented in profit from discontinued operations in 2022.

<table><tr><td></td><td>2022 £m</td></tr><tr><td>Fair value of the Consumer Healthcare business distributed (54.5%)</td><td>15,526</td></tr><tr><td>Fair value of the retained ownership in Haleon plc (13.5%)</td><td>3,853</td></tr><tr><td>Total fair value</td><td>19,379</td></tr><tr><td>Carrying amount of the net assets and liabilities distributed/de-recognised</td><td>(12,887)</td></tr><tr><td>Carrying amount of the non-controlling interest de-recognised</td><td>3,038</td></tr><tr><td>Gain on demerger before exchange movements and transaction costs</td><td>9,530</td></tr><tr><td>Reclassification of exchange movements and net investment hedge movements on disposal of overseas subsidiaries</td><td>554</td></tr><tr><td>Total gain on the demerger of Consumer Healthcare</td><td>10,084</td></tr></table>



## Notes to the financial statements continued

## 41. Acquisitions and disposals continued

Consumer Healthcare was presented as a discontinued operation as at 30 June 2022 and disclosed as such in the interim financial statements. The Consolidated Income Statement and Consolidated Cash Flow Statement distinguish discontinued operations from continuing operations. Comparative figures have been restated on a consistent basis. Financial information relating to the operations of Consumer Healthcare for the period is set out below and includes financial information until 18 July 2022.

This financial information differs both in purpose and basis of preparation from the Historical Financial Information and the Interim Financial Information included in the Haleon prospectus and from that which will be published by Haleon on 2 March 2023. As a result, whilst the two sets of financial information are similar, they are not the same because of certain differences in accounting and disclosure under IFRS.

<table><tr><td>Total results</td><td>2022
£m</td><td>2021
£m</td><td>2020
£m</td></tr><tr><td>Turnover</td><td>5,581</td><td>9,418</td><td>9,745</td></tr><tr><td>Expense</td><td>(4,730)</td><td>(7,575)</td><td>(7,947)</td></tr><tr><td>Profit before tax</td><td>851</td><td>1,843</td><td>1,798</td></tr><tr><td>Taxation</td><td>(235)</td><td>(263)</td><td>(513)</td></tr><tr><td>Tax rate %</td><td>27.6%</td><td>14.3%</td><td>28.5%</td></tr><tr><td>(Loss)/profit after taxation from discontinued operations: Consumer Healthcare</td><td>616</td><td>1,580</td><td>1,285</td></tr><tr><td>Other gains/(losses) on demerger</td><td>2,433</td><td>-</td><td>-</td></tr><tr><td>Remeasurement of discontinued operations distributed to shareholders on demerger</td><td>7,651</td><td>-</td><td>-</td></tr><tr><td>Profit after taxation on demerger of discontinued operations</td><td>10,700</td><td>1,580</td><td>1,285</td></tr><tr><td>Non-controlling interest in discontinued operations</td><td>205</td><td>511</td><td>409</td></tr><tr><td>Earnings attributable to shareholders from discontinued operations</td><td>10,495</td><td>1,069</td><td>876</td></tr><tr><td>Earnings per share from discontinued operations</td><td>260.6p</td><td>26.7p</td><td>22.0p</td></tr></table>

## Other business disposals

There were no other material business disposals in 2022.

<table><tr><td>Cash flows</td><td>Business acquisitions £m</td><td>Business disposals - demerger £m</td><td>Business disposals - other £m</td></tr><tr><td>Cash consideration</td><td>(3,392)</td><td>-</td><td>-</td></tr><tr><td>Net deferred consideration paid</td><td>-</td><td>-</td><td>(34)</td></tr><tr><td>Cash and cash equivalents (divested)/acquired</td><td>284</td><td>(933)</td><td>(9)</td></tr><tr><td></td><td>(3,108)</td><td>(933)</td><td>(43)</td></tr><tr><td>Transaction costs paid</td><td>(79)</td><td>(141)</td><td>-</td></tr><tr><td>Cash (outflow)/inflow</td><td>(3,187)</td><td>(1,074)</td><td>(43)</td></tr></table>

Cash consideration for business acquisitions included £5 million related to other business acquisition activity.

## 2021

## Business acquisitions

GSK completed no material business acquisitions in 2021.

## Business disposals

GSK made a number of business disposals for net cash consideration received in the year of £10 million. The profit on the disposal of the businesses in the year of £24 million was calculated as follows:

<table><tr><td></td><td>Total £m</td></tr><tr><td>Consideration:</td><td></td></tr><tr><td>Cash consideration including currency forwards, purchase adjustments and deferred consideration</td><td>10</td></tr><tr><td>Total</td><td>10</td></tr><tr><td>Net assets sold:</td><td></td></tr><tr><td>Property, plant and equipment</td><td>3</td></tr><tr><td>Cash and cash equivalents</td><td>1</td></tr><tr><td>Other net assets</td><td>1</td></tr><tr><td>Total</td><td>5</td></tr><tr><td>Costs:</td><td></td></tr><tr><td>Deal costs</td><td>(16)</td></tr><tr><td>Reclassification of exchange from other comprehensive income</td><td>35</td></tr><tr><td>Gain on disposals in 2021</td><td>24</td></tr></table>



## Notes to the financial statements continued

## 41. Acquisitions and disposals continued

## Associates and joint ventures

On 20 May 2021 GSK agreed with Innoviva, Inc. ("Innoviva") to sell all of its approximately 32 million shares of common stock of Innoviva back to Innoviva at a price of $12.25 per share, raising gross proceeds of approximately $392 million. Following settlement of the transaction, GSK will no longer hold any Innoviva stock. See details in Note 21 'Investment in associates and joint ventures'.

## Cash flows

<table><tr><td></td><td>Business disposals £m</td><td>Associates and joint ventures disposals £m</td></tr><tr><td>Cash consideration received</td><td>43</td><td>277</td></tr><tr><td>Net deferred consideration paid</td><td>(51)</td><td>-</td></tr><tr><td>Transaction costs</td><td>(8)</td><td>-</td></tr><tr><td>Cash and cash equivalents (divested)/acquired</td><td>(1)</td><td>-</td></tr><tr><td>Cash (outflow)/inflow</td><td>(17)</td><td>277</td></tr></table>

## 2020

## Business acquisitions

GSK completed one smaller business acquisition when it acquired 55% of Pfizer Biotech Corporation Taiwan, a part of Pfizer's consumer healthcare business, which was not previously recognised as part of the Consumer Healthcare Joint Venture, on 28 September 2020 for non cash consideration of £129 million. This represented goodwill of £124 million, cash of £21 million and other assets acquired of £18 million less non-controlling interest of £14 million and net liabilities of £20 million.

<table><tr><td></td><td>Total £m</td></tr><tr><td>Net assets acquired:</td><td></td></tr><tr><td>Intangible assets</td><td>2</td></tr><tr><td>Property, plant and equipment</td><td>5</td></tr><tr><td>Inventory</td><td>5</td></tr><tr><td>Trade and other receivables</td><td>6</td></tr><tr><td>Cash and cash equivalents</td><td>21</td></tr><tr><td>Trade and other payables</td><td>(20)</td></tr><tr><td></td><td>19</td></tr><tr><td>Non-controlling interest</td><td>(14)</td></tr><tr><td>Goodwill</td><td>124</td></tr><tr><td></td><td>129</td></tr><tr><td>Non-cash consideration (settlement of a promissory note)</td><td>129</td></tr><tr><td>Total consideration</td><td>129</td></tr></table>

## Business disposals

On 1 April 2020, GSK completed its divestment of Horlicks and other Consumer Healthcare nutrition products in India and a number of other countries (excluding Bangladesh) to Unilever and the merger of GSK's Indian listed Consumer Healthcare entity with Hindustan Unilever, an Indian listed public company. GSK received a 5.7% equity stake in Hindustan Unilever and £395 million in cash. GSK disposed of its equity stake in Hindustan Unilever during May 2020.

The divestment in Bangladesh closed on 30 June 2020. Total cash consideration received was £177 million.

The cash divested as part of the disposal of the India and Bangladesh Consumer Healthcare entities was £478 million.



## Notes to the financial statements continued

## 41. Acquisitions and disposals continued

The profit on the disposal of the businesses in the year of £2,795 million was calculated as follows:

<table><tr><td></td><td>Horlicks divestment £m</td><td>Other \( ^{\textregistered} \)  £m</td><td>Total £m</td></tr><tr><td>Consideration:</td><td></td><td></td><td></td></tr><tr><td>Cash consideration receivable including currency forwards and purchase adjustments</td><td>492</td><td>157</td><td>649</td></tr><tr><td>Equity investment in Hindustan Unilever Limited</td><td>3,124</td><td>-</td><td>3,124</td></tr><tr><td>Total</td><td>3,616</td><td>157</td><td>3,773</td></tr><tr><td>Net assets disposed:</td><td></td><td></td><td></td></tr><tr><td>Goodwill</td><td>142</td><td>1</td><td>143</td></tr><tr><td>Intangible assets</td><td>15</td><td>103</td><td>118</td></tr><tr><td>Property, plant and equipment</td><td>56</td><td>12</td><td>68</td></tr><tr><td>Inventory</td><td>-</td><td>6</td><td>6</td></tr><tr><td>Cash and cash equivalents</td><td>478</td><td>3</td><td>481</td></tr><tr><td>Other net (liabilities)/assets</td><td>(155)</td><td>1</td><td>(154)</td></tr><tr><td>Total</td><td>536</td><td>126</td><td>662</td></tr><tr><td>Costs:</td><td></td><td></td><td></td></tr><tr><td>Transaction costs</td><td>12</td><td>28</td><td>40</td></tr><tr><td>Derivative</td><td>240</td><td>-</td><td>240</td></tr><tr><td>Reclassification of exchange from other comprehensive income</td><td>36</td><td>-</td><td>36</td></tr><tr><td>Total</td><td>288</td><td>28</td><td>316</td></tr><tr><td>Gain on disposals</td><td>2,792</td><td>3</td><td>2,795</td></tr></table>

The exposure to share price movements embedded in the agreement to merge GSK’s Indian listed Consumer Healthcare entity with Hindustan Unilever Limited as part of the divestment of Horlicks and other nutrition products in India and a number of other countries was recognised as a derivative between signing of the agreement in 2018 and completion of the transaction in 2020. £240 million is recorded as a cost in the table above for the derecognition of the derivative asset. This largely reflects fair value gains recognised in the Income Statement in prior periods.

## Associates and joint ventures

During the year, GSK made investments into associates of £4 million and £4 million was paid in cash.

<table><tr><td>Cash flows</td><td>Business acquisitions £m</td><td>Business disposals £m</td><td>Associates and joint ventures investments £m</td></tr><tr><td>Cash consideration received/(paid)</td><td>-</td><td>786</td><td>(4)</td></tr><tr><td>Net deferred consideration</td><td>-</td><td>(19)</td><td>-</td></tr><tr><td>Transaction costs</td><td>(6)</td><td>(27)</td><td>-</td></tr><tr><td>Cash and cash equivalents acquired/(divested)</td><td>21</td><td>(481)</td><td>-</td></tr><tr><td>Cash (outflow)/inflow</td><td>15</td><td>259</td><td>(4)</td></tr></table>



## 42. Adjustments reconciling Total profit after tax to operating cash flows

<table><tr><td></td><td>2022
£m</td><td>2021(1)
£m</td><td>2020(1)
£m</td></tr><tr><td>Total profit after tax from continuing operations</td><td>4,921</td><td>3,516</td><td>5,103</td></tr><tr><td>Tax on profits</td><td>707</td><td>83</td><td>67</td></tr><tr><td>Share of after-tax profits of associates and joint ventures</td><td>2</td><td>(33)</td><td>(33)</td></tr><tr><td>Finance expense net of finance income</td><td>803</td><td>755</td><td>842</td></tr><tr><td>Depreciation</td><td>1,061</td><td>1,034</td><td>1,004</td></tr><tr><td>Amortisation of intangible assets</td><td>1,086</td><td>1,088</td><td>1,046</td></tr><tr><td>Impairment and assets written off</td><td>481</td><td>529</td><td>684</td></tr><tr><td>Profit on sale of businesses</td><td>(36)</td><td>(47)</td><td>(2,815)</td></tr><tr><td>Profit on sale of intangible assets</td><td>(185)</td><td>(539)</td><td>(279)</td></tr><tr><td>Loss on sale of investments in associates</td><td>-</td><td>36</td><td>-</td></tr><tr><td>Profit on sale of equity investments</td><td>(1)</td><td>(8)</td><td>(69)</td></tr><tr><td>Changes in working capital:</td><td></td><td></td><td></td></tr><tr><td>Decrease/(increase) in inventories</td><td>(269)</td><td>51</td><td>100</td></tr><tr><td>Increase in trade receivables</td><td>(158)</td><td>(780)</td><td>(279)</td></tr><tr><td>Increase in trade payables</td><td>494</td><td>229</td><td>132</td></tr><tr><td>(Increase) in other receivables</td><td>(458)</td><td>(382)</td><td>(349)</td></tr><tr><td>Contingent consideration paid (see Note 33)</td><td>(1,058)</td><td>(742)</td><td>(765)</td></tr><tr><td>Other non-cash increase in contingent consideration liabilities</td><td>1,628</td><td>1,063</td><td>1,275</td></tr><tr><td>Increase in other payables</td><td>(5)</td><td>1,505</td><td>885</td></tr><tr><td>Increase/(decrease) in pension and other provisions</td><td>(962)</td><td>(299)</td><td>428</td></tr><tr><td>Share-based incentive plans</td><td>346</td><td>343</td><td>337</td></tr><tr><td>Fair value adjustments</td><td>(283)</td><td>(31)</td><td>373</td></tr><tr><td>Other</td><td>(170)</td><td>(122)</td><td>(13)</td></tr><tr><td>Operating cash flow from continuing operations</td><td>7,944</td><td>7,249</td><td>7,674</td></tr><tr><td>Operating cash flow from discontinued operations</td><td>932</td><td>1,994</td><td>2,422</td></tr><tr><td>Total cash generated from operations</td><td>8,876</td><td>9,243</td><td>10,096</td></tr></table>

(1) The 2021 and 2020 comparatives have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see Note 4).



## 43. Reconciliation of net cash flow to movement in net debt

<table><tr><td></td><td></td><td>2022
£m</td><td>2021
£m</td><td>2020
£m</td></tr><tr><td>Net debt, at beginning of year, as adjusted</td><td></td><td>(19,838)</td><td>(20,780)</td><td>(25,215)</td></tr><tr><td>Increase in cash and bank overdrafts</td><td></td><td>(7,597)</td><td>(2,504)</td><td>(1,579)</td></tr><tr><td>Increase/(decrease) in liquid investments</td><td></td><td>(1)</td><td>(18)</td><td>1</td></tr><tr><td>Increase in long-term loans</td><td></td><td>(1,025)</td><td>-</td><td>(3,298)</td></tr><tr><td>Repayment of short-term Notes</td><td></td><td>5,074</td><td>2,304</td><td>3,738</td></tr><tr><td>Repayment of/(increase in) other short-term loans</td><td></td><td>(1,021)</td><td>(301)</td><td>3,594</td></tr><tr><td>Repayment of medium term notes (MTNs)</td><td></td><td>1,594</td><td>-</td><td>-</td></tr><tr><td>Repayment of lease liabilities</td><td></td><td>202</td><td>181</td><td>182</td></tr><tr><td>Debt of subsidiary undertakings acquired</td><td></td><td>(24)</td><td>-</td><td>-</td></tr><tr><td>Exchange adjustments</td><td></td><td>(1,531)</td><td>314</td><td>(128)</td></tr><tr><td>Other non-cash movements</td><td></td><td>(207)</td><td>(134)</td><td>(102)</td></tr><tr><td>Decrease/(increase) in net debt from continuing operations</td><td></td><td>(4,536)</td><td>(158)</td><td>2,408</td></tr><tr><td>Decrease/(increase) in net debt from discontinued operations</td><td></td><td>7177</td><td>1,100</td><td>2,027</td></tr><tr><td>Total net debt at end of year</td><td></td><td>(17,197)</td><td>(19,838)</td><td>(20,780)</td></tr></table>

<table><tr><td>Analysis of changes in net debt</td><td>At 1 January 2022 £m</td><td>Exchange £m</td><td>Other £m</td><td>Interest expense £m</td><td>Change in fair value £m</td><td>Reclassifications £m</td><td>Demerger £m</td><td>Cash flow £m</td><td>At 31 December 2022 £m</td></tr><tr><td>Liquid investments</td><td>61</td><td>7</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>(1)</td><td>67</td></tr><tr><td>Cash and cash equivalents</td><td>3,861</td><td>99</td><td>1</td><td>-</td><td>-</td><td>-</td><td>7,496</td><td>(7,734)</td><td>3,723</td></tr><tr><td>Overdrafts</td><td>(450)</td><td>15</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>137</td><td>(298)</td></tr><tr><td>Liquid investments attributed to continuing operations</td><td>3,411</td><td>114</td><td>1</td><td>-</td><td>-</td><td>-</td><td>7,496</td><td>(7,597)</td><td>3,425</td></tr><tr><td>Liquid investments attributed to discontinued operations</td><td>407</td><td>37</td><td>-</td><td>-</td><td>-</td><td>-</td><td>(7,496)</td><td>7,052</td><td>-</td></tr><tr><td></td><td>3,818</td><td>151</td><td>1</td><td>-</td><td>-</td><td>-</td><td>-</td><td>(545)</td><td>3,425</td></tr><tr><td>Debt due within one year:</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Commercial paper</td><td>(252)</td><td>(30)</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>(909)</td><td>(1,191)</td></tr><tr><td>European/US MTN &amp; Bank facilities</td><td>(2,596)</td><td>(174)</td><td>-</td><td>-</td><td>-</td><td>(4,426)</td><td>-</td><td>5,050</td><td>(2,146)</td></tr><tr><td>Lease liabilities</td><td>(173)</td><td>(14)</td><td>5</td><td>-</td><td>-</td><td>(186)</td><td>-</td><td>201</td><td>(167)</td></tr><tr><td>Other</td><td>(52)</td><td>(2)</td><td>(9)</td><td>-</td><td>-</td><td>-</td><td>-</td><td>(87)</td><td>(150)</td></tr><tr><td>Debt due within one year attributed to continuing operations</td><td>(3,073)</td><td>(220)</td><td>(4)</td><td>-</td><td>-</td><td>(4,612)</td><td>-</td><td>4,255</td><td>(3,654)</td></tr><tr><td>Debt due within one year attributed to discontinued operations</td><td>(72)</td><td>(3)</td><td>(15)</td><td>-</td><td>-</td><td>(3)</td><td>1,559</td><td>(1,466)</td><td>-</td></tr><tr><td></td><td>(3,145)</td><td>(223)</td><td>(19)</td><td>-</td><td>-</td><td>(4,615)</td><td>1,559</td><td>2,789</td><td>(3,654)</td></tr><tr><td>Debt due after one year:</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>European/US MTN &amp; Bank facilities</td><td>(19,760)</td><td>(1,386)</td><td>-</td><td>(43)</td><td>-</td><td>4,426</td><td>-</td><td>569</td><td>(16,194)</td></tr><tr><td>Lease liabilities</td><td>(725)</td><td>(59)</td><td>(243)</td><td>-</td><td>-</td><td>186</td><td>-</td><td>-</td><td>(841)</td></tr><tr><td>Debt due after one year attributed to continuing operations</td><td>(20,485)</td><td>(1,445)</td><td>(243)</td><td>(43)</td><td>-</td><td>4,612</td><td>-</td><td>569</td><td>(17,035)</td></tr><tr><td>Debt due after one year attributed to discontinued operations</td><td>(87)</td><td>(777)</td><td>(6)</td><td>(4)</td><td>48</td><td>3</td><td>10,059</td><td>(9,236)</td><td>-</td></tr><tr><td></td><td>(20,572)</td><td>(2,222)</td><td>(249)</td><td>(47)</td><td>48</td><td>4,615</td><td>10,059</td><td>(8,667)</td><td>(17,035)</td></tr><tr><td>Net debt</td><td>(19,838)</td><td>(2,287)</td><td>(267)</td><td>(47)</td><td>48</td><td>-</td><td>11,618</td><td>(6,424)</td><td>(17,197)</td></tr><tr><td>Interest payable</td><td>(244)</td><td>(5)</td><td>(33)</td><td>(865)</td><td>-</td><td>-</td><td>92</td><td>848</td><td>(207)</td></tr><tr><td>Derivative financial instruments</td><td>(22)</td><td>-</td><td>-</td><td>-</td><td>670</td><td>-</td><td>-</td><td>(640)</td><td>8</td></tr><tr><td>Total liabilities from financing activities*</td><td>(23,983)</td><td>(2,450)</td><td>(301)</td><td>(912)</td><td>718</td><td>-</td><td>11,710</td><td>(5,670)</td><td>(20,888)</td></tr></table>

* Excluding cash and cash equivalents, overdrafts and liquid investments.



## Notes to the financial statements continued

## 43. Reconciliation of net cash flow to movement in net debt continued

<table><tr><td>Analysis of changes in net debt</td><td>At 1 January 2021 £m</td><td>Exchange £m</td><td>Other £m</td><td>Interest expense £m</td><td>Change in fair value £m</td><td>Reclassifications £m</td><td>Cash flow £m</td><td>At 31 December 2021 £m</td></tr><tr><td>Liquid investments</td><td>78</td><td>1</td><td>-</td><td>-</td><td>-</td><td>-</td><td>(18)</td><td>61</td></tr><tr><td>Cash and cash equivalents</td><td>6,292</td><td>(29)</td><td>(1)</td><td>-</td><td>-</td><td>-</td><td>(1,988)</td><td>4,274</td></tr><tr><td>Overdrafts</td><td>(1,030)</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>574</td><td>(456)</td></tr><tr><td></td><td>5,262</td><td>(29)</td><td>(1)</td><td>-</td><td>-</td><td>-</td><td>(1,414)</td><td>3,818</td></tr><tr><td>Debt due within one year:</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Commercial paper</td><td>(17)</td><td>8</td><td>-</td><td>-</td><td>-</td><td>-</td><td>(243)</td><td>(252)</td></tr><tr><td>European/US MTN &amp; Bank facilities</td><td>(2,350)</td><td>1</td><td>-</td><td>-</td><td>-</td><td>(2,494)</td><td>2,247</td><td>(2,596)</td></tr><tr><td>Lease liabilities</td><td>(230)</td><td>5</td><td>7</td><td>-</td><td>-</td><td>(200)</td><td>215</td><td>(203)</td></tr><tr><td>Other</td><td>(98)</td><td>15</td><td>(2)</td><td>-</td><td>-</td><td>-</td><td>(9)</td><td>(94)</td></tr><tr><td></td><td>(2,695)</td><td>29</td><td>5</td><td>-</td><td>-</td><td>(2,694)</td><td>2,210</td><td>(3,145)</td></tr><tr><td>Debt due after one year:</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>European/US MTN &amp; Bank facilities</td><td>(22,538)</td><td>306</td><td>-</td><td>(22)</td><td>-</td><td>2,494</td><td>-</td><td>(19,760)</td></tr><tr><td>Lease liabilities</td><td>(887)</td><td>7</td><td>(132)</td><td>-</td><td>-</td><td>200</td><td>-</td><td>(812)</td></tr><tr><td></td><td>(23,425)</td><td>313</td><td>(132)</td><td>(22)</td><td>-</td><td>2,694</td><td>-</td><td>(20,572)</td></tr><tr><td>Net debt</td><td>(20,780)</td><td>314</td><td>(128)</td><td>(22)</td><td>-</td><td>-</td><td>778</td><td>(19,838)</td></tr><tr><td>Interest payable</td><td>(247)</td><td>-</td><td>(30)</td><td>(753)</td><td>-</td><td>-</td><td>786</td><td>(244)</td></tr><tr><td>Derivative financial instruments</td><td>(74)</td><td>-</td><td>-</td><td>-</td><td>72</td><td>-</td><td>(20)</td><td>(22)</td></tr><tr><td>Total liabilities from financing activities*</td><td>(26,441)</td><td>342</td><td>(157)</td><td>(775)</td><td>72</td><td>-</td><td>2,976</td><td>(23,983)</td></tr></table>

* Excluding cash and cash equivalents, overdrafts and liquid investments.

For further information on significant changes in net debt see Note 30, 'Net debt'.



## 44. Financial instruments and related disclosures

The objective of GSK’s Treasury activities is to minimise the post-tax net cost of financial operations and reduce its volatility to benefit earnings and cash flows. GSK uses a variety of financial instruments to finance its operations and derivative financial instruments to manage market risks from these operations. Derivatives principally comprise foreign exchange forward contracts and swaps which are used to swap borrowings and liquid assets into currencies required for Group purposes as well as interest rate swaps which are used to manage exposure to financial risks from changes in interest rates. These financial instruments reduce the uncertainty of foreign currency transactions and interest payments.

Derivatives are used exclusively for hedging purposes in relation to underlying business activities and not as trading or speculative instruments.

## Capital management

GSK’s financial strategy supports the Group’s strategic priorities and is regularly reviewed by the Board. GSK manages the capital structure of the Group through an appropriate mix of debt and equity.

The capital structure of the Group consists of net debt of €17.2 billion (see Note 30, 'Net debt') and total equity, including items related to non-controlling interests, of €10.1 billion (see 'Consolidated statement of changes in equity' on page 184). Total capital, including that provided by non-controlling interests, is €27.3 billion.

The Group continues to manage its financial policies to a credit profile that particularly targets short-term credit ratings of A-1 and P-1 while maintaining single A long-term ratings consistent with those targets. The Group’s long-term credit rating with Standard & Poor’s is A (stable outlook) and with Moody’s Investor Services (‘Moody’s’) it is A2 (stable outlook). The Group’s short-term credit ratings are A-1 and P-1 with Standard & Poor’s and Moody’s respectively.

## Liquidity risk management

GSK’s policy is to borrow centrally in order to meet anticipated funding requirements. The strategy is to diversify liquidity sources using a range of facilities and to maintain broad access to financial markets. Each day, we sweep cash to or from a number of global subsidiaries and central Treasury accounts for liquidity management purposes. GSK utilises both physical and notional cash pool arrangements as appropriate by location and currency. For notional cash pools, liquidity is drawn against foreign currency balances to provide both local funding and central liquidity as required and with balances actively managed and maintained to appropriate levels. As balances in notional pooling arrangements are not settled across currencies, gross cash and overdraft balances are reported.

At 31 December 2022, GSK had £4 billion of borrowings repayable within one year and held £3.8 billion of cash and cash equivalents and liquid investments of which £3.1 billion was held centrally.
GSK has access to short-term finance under a $10 billion (£8.3 billion) US commercial paper programme; $900 million (£748 million) was in issue at 31 December 2022 (2021: \(nil). GSK has access to short-term finance under a £5 billion Euro commercial paper programme; €500 million (£443 million) was in issue at 31 December 2022 (2021: €300 million (£252 million)). In February 2022 GSK cancelled the £1.9 billion three year and $2.5 billion (£2.1 billion) 364 day committed facilities and replaced them with new revolving credit facilities of equivalent size with maturities of September 2025 and September 2023 respectively. Post separation of the Consumer Healthcare business these facilities were reduced to £1.6 billion and $2.2 billion (£1.8 billion) respectively.

These committed facilities were undrawn at 31 December 2022. GSK considers this level of committed facilities to be adequate, given current liquidity requirements.

GSK has a £20.0 billion Euro Medium Term Note programme and at 31 December 2022, £10.3 billion of notes were in issue under this programme. The Group also had $9.7 billion (£8.1 billion) of notes in issue at 31 December 2022 under a US shelf registration. GSK is currently in the process of renewing its US shelf registration statement in order to maintain access to the US debt markets. GSK’s borrowings mature at dates between 2023 and 2045.

The put option owned by Pfizer in ViiV Healthcare is exercisable. In reviewing liquidity requirements GSK considers that sufficient financing options are available should the put option be exercised.

## Market risk

## Interest rate risk management

GSK’s objective is to minimise the effective net interest cost and to balance the mix of debt at fixed and floating rates over time.

The Group’s main interest rate risk arises from borrowings and investments with floating rates and refinancing of maturing fixed rate debt where any changes in interest rates will affect future cash flows or the fair values of financial instruments. The policy on interest rate risk management limits the net amount of floating rate debt to a specific cap, reviewed and agreed no less than annually by the Board.

The majority of debt is issued at fixed interest rates and changes in the floating rates of interest do not significantly affect the Group’s net interest charge. Short-term borrowings including bank facilities are exposed to the risk of future changes in market interest rates as are the majority of cash and liquid investments.



## Notes to the financial statements continued

## 44. Financial instruments and related disclosures continued

## Foreign exchange risk management

The Group’s objective is to minimise the exposure of overseas operating subsidiaries to transaction risk by matching local currency income with local currency costs where possible. Foreign currency transaction exposures arising on external and internal trade flows are selectively hedged. GSK’s internal trading transactions are matched centrally and inter-company payment terms are managed to reduce foreign currency risk. Where possible, GSK manages the cash surpluses or borrowing requirements of subsidiary companies centrally using forward contracts to hedge future repayments back into the originating currency.

In order to reduce foreign currency translation exposure, the Group seeks to denominate borrowings in the currencies of our principal assets and cash flows. These are primarily denominated in US Dollars, Euros and Sterling. Borrowings can be swapped into other currencies as required.

Borrowings denominated in, or swapped into, foreign currencies that match investments in overseas Group assets may be treated as a hedge against the relevant assets. Forward contracts in major currencies are also used to reduce exposure to the Group’s investment in overseas assets (see ‘Net investment hedges’ section of this note for further details).

## Credit risk

Credit risk is the risk that a counterparty will default on its contractual obligations resulting in financial loss to the Group and arises on cash and cash equivalents and favourable derivative financial instruments held with banks and financial institutions as well as credit exposures to wholesale and retail customers, including outstanding receivables.

The Group considers its maximum credit risk at 31 December 2022 to be £10,180 million (31 December 2021: £11,417 million) which is the total of the Group’s financial assets with the exception of ‘Other investments’ (comprising equity investments) which bear equity risk rather than credit risk. See page 249 for details on the Group’s total financial assets. At 31 December 2022, GSK’s greatest concentration of credit risk was £1.1 billion with a wholesaler in the US (2021: £0.9 billion with a wholesaler in the US). See page 247 for further information on the Group’s credit risk exposure in respect of the three largest US wholesaler customers.

There has been no change in the estimation techniques or significant assumptions made during the current reporting period in assessing the loss allowance for financial assets at amortised cost or at FVTOCI since the adoption of IFRS 9 at the start of the 2018 reporting period.

## Treasury-related credit risk

GSK sets global counterparty limits for each of GSK’s banking and investment counterparties based on long-term credit ratings from Moody’s and Standard & Poor’s. Usage of these limits is actively monitored.

GSK actively manages its exposure to credit risk, reducing surplus cash balances wherever possible. This is part of GSK’s strategy to regionalise cash management and to concentrate cash centrally as much as possible. The table below sets out the credit exposure to counterparties by rating for liquid investments, cash and cash equivalents and derivatives.

The gross asset position on each derivative contract is considered for the purpose of this table, although, under ISDA agreements, the amount at risk is the net position with each counterparty. Table (e) on page 257 sets out the Group’s financial assets and liabilities on an offset basis.



## Notes to the financial statements continued

## 44. Financial instruments and related disclosures continued

At 31 December 2022, £60 million (2021: £54 million) of cash is categorised as held with unrated or sub-investment grade rated counterparties (lower than BBB-/Baa3) of which £nil (2021: £7 million) is cash in transit. The remaining exposure is concentrated in overseas banks used for local cash management or investment purposes, including: £23 million in Nigeria held with United Bank for Africa, Zenith Bank, Access Bank and Stanbic IBTC Bank; £14 million with Halk Bank in the UK; £6 million with Produbanco in Ecuador; £2 million with J Trust Royal Bank in Cambodia; £2 million with Banco Do Brasil in Brazil; £1 million with Banco de Honduras in Honduras; and £1 million with BAC San José in Costa Rica. Of the £49 million of bank balances and deposits held with BBB/Baa rated counterparties, £1.4 million was held with BBB-/Baa3 rated counterparties, including balances or deposits of £1 million with State Bank of India in India. These banks are used for local investment purposes.

GSK measures expected credit losses over cash and cash equivalents as a function of individual counterparty credit ratings and associated 12 month default rates. Expected credit losses over cash and cash equivalents and third-party financial derivatives are deemed to be immaterial and no such loss has been experienced during 2022.

Credit ratings are assigned by Standard & Poor’s and Moody’s respectively. Where the opinions of the two rating agencies differ, GSK assigns the lower rating of the two to the counterparty. Where local rating agency or Fitch data is the only source available, the ratings are converted to global ratings equivalent to those of Standard & Poor’s or Moody’s using published conversion tables. These credit ratings form the basis of the assessment of the expected credit loss on Treasury-related balances held at amortised cost being bank balances and deposits and Government securities.

<table><tr><td>2022</td><td>AAA/Aaa
£m</td><td>AA/Aa
£m</td><td>A/A
£m</td><td>BBB/Baa
£m</td><td>BB+/Bal
and below
/Unrated
£m</td><td>Total
£m</td></tr><tr><td>Bank balances and deposits</td><td>-</td><td>-</td><td>1,215</td><td>49</td><td>60</td><td>1,324</td></tr><tr><td>US Treasury and Treasury repo only money market funds</td><td>146</td><td>-</td><td>-</td><td>-</td><td>-</td><td>146</td></tr><tr><td>Liquidity funds</td><td>2,253</td><td>-</td><td>-</td><td>-</td><td>-</td><td>2,253</td></tr><tr><td>Government securities</td><td>-</td><td>67</td><td>-</td><td>-</td><td>-</td><td>67</td></tr><tr><td>Third party financial derivatives</td><td>-</td><td>-</td><td>188</td><td>-</td><td>-</td><td>188</td></tr><tr><td>Total</td><td>2,399</td><td>67</td><td>1,403</td><td>49</td><td>60</td><td>3,978</td></tr></table>

<table><tr><td>2021</td><td>AAA/Aaa
£m</td><td>AA/Aa
£m</td><td>A/A
£m</td><td>BBB/Baa
£m</td><td>BB+/Bal
and below
/Unrated
£m</td><td>Total
£m</td></tr><tr><td>Bank balances and deposits</td><td>-</td><td>7</td><td>2,687</td><td>77</td><td>54</td><td>2,825</td></tr><tr><td>US Treasury and Treasury repo only money market funds</td><td>54</td><td>-</td><td>-</td><td>-</td><td>-</td><td>54</td></tr><tr><td>Liquidity funds</td><td>1,395</td><td>-</td><td>-</td><td>-</td><td>-</td><td>1,395</td></tr><tr><td>Government securities</td><td>-</td><td>60</td><td>-</td><td>1</td><td>-</td><td>61</td></tr><tr><td>Third party financial derivatives</td><td>-</td><td>-</td><td>200</td><td>-</td><td>-</td><td>200</td></tr><tr><td>Total</td><td>1,449</td><td>67</td><td>2,887</td><td>78</td><td>54</td><td>4,535</td></tr></table>

GSK’s centrally managed cash reserves amounted to £3.1 billion at 31 December 2022, all available within three months. This includes £2.2 billion of cash managed by the Group for ViV Healthcare, a 78.3% owned subsidiary. The Group has invested centrally managed liquid assets in bank deposits, Aaa/AAA rated US Treasury and Treasury repo only money market funds and Aaa/AAA rated liquidity funds.

## Wholesale and retail credit risk

Outside the US, no customer accounts for more than 5% of the Group’s trade receivables balance.

In the US, in line with other pharmaceutical companies, the Group sells its products through a small number of wholesalers in addition to hospitals, pharmacies, physicians and other groups. Sales to the three largest wholesalers amounted to approximately 79% (2021: 75%) of the sales of the US Commercial Operations business in 2022.

At 31 December 2022, the Group had trade receivables due from these three wholesalers totalling £3,001 million or 55% of total trade receivables (2021: £2,430 million or 39%). The Group is exposed to a concentration of credit risk in respect of these wholesalers such that, if one or more of them encounters financial difficulty, it could materially and adversely affect the Group's financial results.
This concentration of trade receivables is reflective of standard market practice in the US pharmaceuticals sector where a significant portion of sales are made to these three wholesalers, as disclosed in Note 6. GSK’s assessment is that there is limited credit risk associated with these customers.

The Group’s credit risk monitoring activities relating to these wholesalers include a review of their quarterly financial information and Standard & Poor’s credit ratings, development of GSK internal risk ratings, and establishment and periodic review of credit limits.

All new customers are subject to a credit vetting process and existing customers will be subject to a review at least annually. The vetting process and subsequent reviews involve obtaining information including the customer’s status as a government or private sector entity, audited financial statements, credit bureau reports, debt rating agency (eg Moody’s, Standard & Poor’s) reports, payment performance history (from trade references, industry credit groups) and bank references.



## Notes to the financial statements continued

## 44. Financial instruments and related disclosures continued

Trade receivables consist of amounts due from a large number of customers, spread across diverse industries and geographical areas. Ongoing credit evaluation is performed on the financial condition of accounts receivable and, where appropriate, credit insurance is purchased or factoring arrangements put in place.

The amount of information obtained is proportional to the level of exposure being considered. The information is evaluated quantitatively (i.e. credit score) and qualitatively (i.e. judgement) in conjunction with the customer's credit requirements to determine a credit limit.

Trade receivables are grouped into customer segments that have similar loss patterns to assess credit risk while other receivables and other financial assets are assessed individually. Historical and forward-looking information is considered to determine the appropriate expected credit loss allowance.

The Group believes there is no further credit risk provision required in excess of the allowance for expected credit losses (see Note 26, 'Trade and other receivables').

## Credit enhancements

The Group uses credit enhancements including factoring and credit insurance to minimise the credit risk of the trade receivables in the Group. At 31 December 2022, £332 million (2021: £315 million) of trade receivables were insured in order to protect the receivables from loss due to credit risks such as default, insolvency and bankruptcy.

Each Group entity assesses the credit risk of its private customers to determine if credit insurance is required.

Factoring arrangements are managed locally by entities and are used to mitigate risk arising from large credit risk concentrations. All factoring arrangements are non-recourse.

## Fair value of financial assets and liabilities excluding lease liabilities

The table on page 249 presents the carrying amounts and the fair values of the Group’s financial assets and liabilities excluding lease liabilities at 31 December 2022 and 31 December 2021.

The fair values of the financial assets and liabilities are included at the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date.

The following methods and assumptions are used to measure the fair values of significant financial instruments carried at fair value on the balance sheet:

– Other investments – equity investments traded in an active market determined by reference to the relevant stock exchange quoted bid price; other equity investments determined by reference to the current market value of similar instruments, recent financing rounds or the discounted cash flows of the underlying net assets

– Trade receivables carried at fair value – based on invoiced amount

– Interest rate swaps, foreign exchange forward contracts, swaps and options – based on the present value of contractual cash flows or option valuation models using market sourced data (exchange rates or interest rates) at the balance sheet date

– Cash and cash equivalents carried at fair value – based on net asset value of the funds

– Contingent consideration for business acquisitions and divestments – based on present values of expected future cash flows.

The following methods and assumptions are used to estimate the fair values of significant financial instruments which are not measured at fair value on the balance sheet:

– Receivables and payables, including put options, carried at amortised cost – approximates to the carrying amount

– Liquid investments – approximates to the carrying amount

– Cash and cash equivalents carried at amortised cost – approximates to the carrying amount

– Long-term loans – based on quoted market prices (a level 1 fair value measurement) in the case of European and US Medium Term Notes; approximates to the carrying amount in the case of other fixed rate borrowings and floating rate bank loans

– Short-term loans, overdrafts and commercial paper – approximates to the carrying amount because of the short maturity of these instruments.



## Notes to the financial statements continued

## 44. Financial instruments and related disclosures continued

<table><tr><td rowspan="2"></td><td rowspan="2">Notes</td><td colspan="3">2022</td><td>2021</td></tr><tr><td>Carrying value £m</td><td>Fair value £m</td><td>Carrying value £m</td><td>Fair value £m</td></tr><tr><td>Financial assets measured at amortised cost:</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Other non-current assets</td><td>b</td><td>21</td><td>21</td><td>21</td><td>21</td></tr><tr><td>Trade and other receivables</td><td>b</td><td>3,789</td><td>3,789</td><td>4,830</td><td>4,830</td></tr><tr><td>Liquid investments</td><td></td><td>67</td><td>67</td><td>61</td><td>61</td></tr><tr><td>Cash and cash equivalents</td><td></td><td>1,324</td><td>1,324</td><td>2,825</td><td>2,825</td></tr><tr><td>Financial assets measured at fair value through other comprehensive income (FVOCI):</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Other investments designated at FVTOCI</td><td>a</td><td>1,153</td><td>1,153</td><td>1,927</td><td>1,927</td></tr><tr><td>Trade and other receivables</td><td>ab</td><td>2,327</td><td>2,327</td><td>1,943</td><td>1,943</td></tr><tr><td>Financial assets mandatorily measured at fair value through profit or loss (FVTPL):</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Current equity investments and Other investments</td><td>a</td><td>4,401</td><td>4,401</td><td>199</td><td>199</td></tr><tr><td>Other non-current assets</td><td>ab</td><td>13</td><td>13</td><td>23</td><td>23</td></tr><tr><td>Trade and other receivables</td><td>ab</td><td>50</td><td>50</td><td>59</td><td>59</td></tr><tr><td>Held for trading derivatives that are not in a designated and effective hedging relationship</td><td>a,d,e</td><td>165</td><td>165</td><td>83</td><td>83</td></tr><tr><td>Cash and cash equivalents</td><td>a</td><td>2,399</td><td>2,399</td><td>1,449</td><td>1,449</td></tr><tr><td>Derivatives designated and effective as hedging instruments (fair value movements through Other comprehensive income)</td><td>a,d,e</td><td>25</td><td>25</td><td>123</td><td>123</td></tr><tr><td>Total financial assets</td><td></td><td>15,734</td><td>15,734</td><td>13,543</td><td>13,543</td></tr><tr><td>Financial liabilities measured at amortised cost:</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Borrowings excluding obligations under lease liabilities:</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>- bonds in a designated hedging relationship</td><td>d</td><td>(6,322)</td><td>(6,035)</td><td>(4,982)</td><td>(5,311)</td></tr><tr><td>- other bonds</td><td></td><td>(12,017)</td><td>(11,930)</td><td>(17,373)</td><td>(20,746)</td></tr><tr><td>- bank loans and overdrafts</td><td></td><td>(447)</td><td>(447)</td><td>(550)</td><td>(550)</td></tr><tr><td>- commercial paper in a designated hedging relationship</td><td></td><td>(443)</td><td>(443)</td><td>(252)</td><td>(252)</td></tr><tr><td>- other commercial paper</td><td></td><td>(748)</td><td>(748)</td><td>-</td><td>-</td></tr><tr><td>- other borrowings</td><td></td><td>(2)</td><td>(2)</td><td>(1)</td><td>(1)</td></tr><tr><td>Total borrowings excluding lease liabilities</td><td>f</td><td>(1,997)</td><td>(19,605)</td><td>(23,158)</td><td>(26,860)</td></tr><tr><td>Trade and other payables</td><td>c</td><td>(14,065)</td><td>(14,065)</td><td>(15,431)</td><td>(15,431)</td></tr><tr><td>Other provisions</td><td>d</td><td>(63)</td><td>(63)</td><td>(113)</td><td>(113)</td></tr><tr><td>Other non-current liabilities</td><td>c</td><td>(84)</td><td>(84)</td><td>(52)</td><td>(52)</td></tr><tr><td>Financial liabilities mandatorily measured at fair value through profit or loss (FVTPL):</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Contingent consideration liabilities</td><td>a,c</td><td>(7,068)</td><td>(7,068)</td><td>(6,076)</td><td>(6,076)</td></tr><tr><td>Held for trading derivatives that are not in a designated and effective hedging relationship</td><td>a,d,e</td><td>(77)</td><td>(77)</td><td>(171)</td><td>(171)</td></tr><tr><td>Derivatives designated and effective as hedging instruments (fair value movements through Other comprehensive income)</td><td>a,d,e</td><td>(106)</td><td>(106)</td><td>(57)</td><td>(57)</td></tr><tr><td>Total financial liabilities excluding lease liabilities</td><td></td><td>(41,442)</td><td>(41,068)</td><td>(45,058)</td><td>(48,760)</td></tr><tr><td>Net financial assets and financial liabilities excluding lease liabilities</td><td></td><td>(25,708)</td><td>(25,334)</td><td>(31,515)</td><td>(35,217)</td></tr></table>

The valuation methodology used to measure fair value in the above table is described and categorised on page 248.

Trade and other receivables, Other non-current assets, Trade and other payables, Other provisions, Contingent consideration liabilities and Other non-current liabilities are reconciled to the relevant Notes on pages 251 to 252.



## Notes to the financial statements continued

## 44. Financial instruments and related disclosures continued

## Fair value of investments in GSK shares

At 31 December 2022, the Employee Share Ownership Plan (ESOP) Trusts held GSK shares with a carrying value of £354 million (2021: £28 million) and a market value of £861 million (2021: £373 million) based on quoted market price. The shares are held by the ESOP Trusts to satisfy future exercises of options and awards under employee incentive schemes. In 2022, the carrying value, which is the lower of cost or expected proceeds, of these shares has been recognised as a deduction from other reserves. At 31 December 2022, GSK held Treasury shares at a cost of £3,797 million (2021: £4,969 million) which has been deducted from retained earnings.

## (a) Financial instruments held at fair value

The following tables categorise the Group’s financial assets and liabilities held at fair value by the valuation methodology applied in determining their fair value. Where possible, quoted prices in active markets are used (Level 1). Where such prices are not available, the asset or liability is classified as Level 2, provided all significant inputs to the valuation model used are based on observable market data. If one or more of the significant inputs to the valuation model is not based on observable market data, the instrument is classified as Level 3. Other investments classified as Level 3 in the tables below comprise equity investments in unlisted entities with which the Group has entered into research collaborations and investments which provide access to biotechnology developments of potential interest.

<table><tr><td>At 31 December 2022</td><td>Level 1
£m</td><td>Level 2
£m</td><td>Level 3
£m</td><td>Total
£m</td></tr><tr><td>Financial assets at fair value</td><td></td><td></td><td></td><td></td></tr><tr><td>Financial assets measured at fair value through other comprehensive income (FVTOCI):</td><td></td><td></td><td></td><td></td></tr><tr><td>Other investments designated at FVTOCI</td><td>823</td><td>-</td><td>330</td><td>1,153</td></tr><tr><td>Trade and other receivables</td><td>-</td><td>2,327</td><td>-</td><td>2,327</td></tr><tr><td>Financial assets mandatorily measured at fair value through profit or loss (FVTPL):</td><td></td><td></td><td></td><td></td></tr><tr><td>Current equity investments and Other investments</td><td>4,087</td><td>-</td><td>314</td><td>4,401</td></tr><tr><td>Other non-current assets</td><td>-</td><td>-</td><td>13</td><td>13</td></tr><tr><td>Trade and other receivables</td><td>-</td><td>50</td><td>-</td><td>50</td></tr><tr><td>Held for trading derivatives that are not in a designated and effective hedging relationship</td><td>-</td><td>165</td><td>-</td><td>165</td></tr><tr><td>Cash and cash equivalents</td><td>2,399</td><td>-</td><td>-</td><td>2,399</td></tr><tr><td>Derivatives designated and effective as hedging instruments (fair value movements through OCI)</td><td>-</td><td>25</td><td>-</td><td>25</td></tr><tr><td></td><td>7,309</td><td>2,567</td><td>657</td><td>10,533</td></tr><tr><td>Financial liabilities at fair value</td><td></td><td></td><td></td><td></td></tr><tr><td>Financial liabilities mandatorily measured at fair value through profit or loss (FVTPL):</td><td></td><td></td><td></td><td></td></tr><tr><td>Contingent consideration liabilities</td><td>-</td><td>-</td><td>(7,068)</td><td>(7,068)</td></tr><tr><td>Held for trading derivatives that are not in a designated and effective hedging relationship</td><td>-</td><td>(77)</td><td>-</td><td>(77)</td></tr><tr><td>Derivatives designated and effective as hedging instruments (fair value movements through OCI)</td><td>-</td><td>(106)</td><td>-</td><td>(106)</td></tr><tr><td></td><td>-</td><td>(183)</td><td>(7,068)</td><td>(7,251)</td></tr></table>

<table><tr><td>At 31 December 2021</td><td>Level 1
£m</td><td>Level 2
£m</td><td>Level 3
£m</td><td>Total
£m</td></tr><tr><td>Financial assets at fair value</td><td></td><td></td><td></td><td></td></tr><tr><td>Financial assets measured at fair value through other comprehensive income (FVTOCI):</td><td></td><td></td><td></td><td></td></tr><tr><td>Other investments designated at FVTOCI</td><td>1736</td><td>-</td><td>191</td><td>1927</td></tr><tr><td>Trade and other receivables</td><td>-</td><td>1943</td><td>-</td><td>1943</td></tr><tr><td>Financial assets mandatorily measured at fair value through profit or loss (FVTPL):</td><td></td><td></td><td></td><td></td></tr><tr><td>Other investments</td><td>-</td><td>-</td><td>199</td><td>199</td></tr><tr><td>Other non-current assets</td><td>-</td><td>-</td><td>23</td><td>23</td></tr><tr><td>Trade and other receivables</td><td>-</td><td>59</td><td>-</td><td>59</td></tr><tr><td>Held for trading derivatives that are not in a designated and effective hedging relationship</td><td>-</td><td>77</td><td>6</td><td>83</td></tr><tr><td>Cash and cash equivalents</td><td>1,449</td><td>-</td><td>-</td><td>1,449</td></tr><tr><td>Derivatives designated and effective as hedging instruments (fair value movements through OCI)</td><td>-</td><td>123</td><td>-</td><td>123</td></tr><tr><td></td><td>3,185</td><td>2,202</td><td>419</td><td>5,806</td></tr><tr><td>Financial liabilities at fair value</td><td></td><td></td><td></td><td></td></tr><tr><td>Financial liabilities mandatorily measured at fair value through profit or loss (FVTPL):</td><td></td><td></td><td></td><td></td></tr><tr><td>Contingent consideration liabilities</td><td>-</td><td>-</td><td>(6,076)</td><td>(6,076)</td></tr><tr><td>Held for trading derivatives that are not in a designated and effective hedging relationship</td><td>-</td><td>(171)</td><td>-</td><td>(171)</td></tr><tr><td>Derivatives designated and effective as hedging instruments (fair value movements through OCI)</td><td>-</td><td>(57)</td><td>-</td><td>(57)</td></tr><tr><td></td><td>-</td><td>(228)</td><td>(6,076)</td><td>(6,304)</td></tr></table>



## Notes to the financial statements continued

## 44. Financial instruments and related disclosures continued

Movements in the year for financial instruments measured using Level 3 valuation methods are presented below:

<table><tr><td></td><td>2022
£m</td><td>2021
£m</td></tr><tr><td>At 1 January</td><td>(5,657)</td><td>(5,064)</td></tr><tr><td>Exchange adjustments</td><td>46</td><td>4</td></tr><tr><td>Net losses recognised in the income statement</td><td>(1,627)</td><td>(1,024)</td></tr><tr><td>Net gains recognised in other comprehensive income</td><td>91</td><td>185</td></tr><tr><td>Contingent consideration related to business acquisitions in the period</td><td>(482)</td><td>-</td></tr><tr><td>Settlement of contingent consideration liabilities</td><td>1,137</td><td>856</td></tr><tr><td>Additions</td><td>97</td><td>99</td></tr><tr><td>Disposals and settlements</td><td>(16)</td><td>(19)</td></tr><tr><td>Transfers from Level 3</td><td>-</td><td>(694)</td></tr><tr><td>At 31 December</td><td>(6,411)</td><td>(5,657)</td></tr></table>

Of the total net losses of £1,627 million (2021: £1,024 million) attributable to Level 3 financial instruments which were recognised in the income statement, £1,623 million (2021: £1,024 million) were in respect of financial instruments which were held at the end of the year and were reported in Other operating income/expense. Charges of £1,431 million (2021: £1,026 million) arose from remeasurement of the contingent consideration payable for the acquisition of the former Shionogi-ViV Healthcare joint venture and £231 million (2021: £32 million) arose from remeasurement of the contingent consideration payable for the acquisition of the Novartis Vaccines business. The acquisition of Affinivax in 2022 resulted in the addition of £482 million of contingent consideration to Level 3 financial liabilities, with a further £17 million remeasurement charge arising for the period between acquisition and 31 December 2022. There were no transfers into or out of Level 3 financial instruments in the year (2021 – transfers related to equity instruments which transferred to a Level 1 valuation methodology as a result of listing on a recognised stock exchange during the year). Movements arising on the translation of overseas net assets for consolidation into the Group accounts are recorded as Exchange adjustments. Net gains and losses include the impact of other exchange movements.

Financial liabilities measured using Level 3 valuation methods at 31 December included £5,890 million (2021: £5,559 million) in respect of contingent consideration payable for the acquisition in 2012 of the former Shionogi-ViV Healthcare joint venture. This consideration is expected to be paid over a number of years and will vary in line with the future performance of specified products and movements in certain foreign currencies. A further £673 million (2021: £479 million) is in respect of contingent consideration for the acquisition in 2015 of the Novartis Vaccines business. This consideration is expected to be paid over a number of years and will vary in line with the future performance of specified products, the achievement of certain milestone targets and movements in certain foreign currencies. As a result of the Group’s acquisition of Affinivax in 2022, contingent consideration payable of £501 million is recognised at 31 December 2022. This consideration is expected to be paid over a number of years and will vary in line with the achievement of certain development milestones and movements in the USD/GBP exchange rate. Sensitivity analysis on these balances is provided in Note 33, ‘Contingent consideration liabilities’.

## (b) Trade and other receivables and Other non-current assets in scope of IFRS 9

The following table reconciles financial instruments within Trade and other receivables and Other non-current assets which fall within the scope of IFRS 9 to the relevant balance sheet amounts. The financial assets are predominantly non-interest earning. Non-financial instruments include tax receivables, pension surplus balances and prepayments, which are outside the scope of IFRS 9.

<table><tr><td rowspan="2"></td><td colspan="12">2022</td></tr><tr><td>At FVTPL £m</td><td>At FVTOCI £m</td><td>Amortised cost £m</td><td>Financial instruments £m</td><td>Financial instruments £m</td><td>Non-FVTPL £m</td><td>At FVTPL £m</td><td>At Amortised cost £m</td><td>Financial instruments £m</td><td>Non-FVTPL £m</td><td>At Amortised cost £m</td><td>Financial instruments £m</td></tr><tr><td>Trade and other receivables (Note 26)</td><td>50</td><td>2,327</td><td>3,789</td><td>6,166</td><td>887</td><td>7,053</td><td>59</td><td>1,943</td><td>4,830</td><td>6,832</td><td>1,028</td><td>7,860</td></tr><tr><td>Other non-current assets (Note 24)</td><td>13</td><td>-</td><td>21</td><td>34</td><td>1,160</td><td>1,194</td><td>23</td><td>-</td><td>21</td><td>44</td><td>1,632</td><td>1,676</td></tr><tr><td></td><td>63</td><td>2,327</td><td>3,810</td><td>6,200</td><td>2,047</td><td>8,247</td><td>82</td><td>1,943</td><td>4,851</td><td>6,876</td><td>2,660</td><td>9,536</td></tr></table>

Trade and other receivables include trade receivables of £5,452 million (2021: £6,246 million). The Group has portfolios in each of the three business models under IFRS 9: £50 million (2021: £59 million), measured at FVTPL, is held to sell the contractual cash flows as the receivables will be sold under a factoring arrangement, £2,327 million (2021: £1,943 million), measured at FVTOCI, is held to either collect or sell the contractual cash flows as the receivables may be sold under a factoring agreement, and £3,075 million (2021: £4,244 million), measured at amortised cost, is held to collect the contractual cash flows and there is no factoring agreement in place.



## Notes to the financial statements continued

## 44. Financial instruments and related disclosures continued

## (c) Trade and other payables, Other provisions, Contingent consideration liabilities and Other non-current liabilities in scope of IFRS 9

The following table reconciles financial instruments within Trade and other payables, Other provisions, Contingent consideration liabilities and Other non-current liabilities which fall within the scope of IFRS 9 to the relevant balance sheet amounts. The financial liabilities are predominantly non-interest bearing. Non-financial instruments include payments on account, tax and social security payables and provisions which do not arise from contractual obligations to deliver cash or another financial asset, which are outside the scope of IFRS 9.

<table><tr><td rowspan="2"></td><td colspan="10">2022</td></tr><tr><td>At FVTPL
£m</td><td>Amortised
cost
£m</td><td>Financial
instruments
£m</td><td>Non-
financial
instruments
£m</td><td>Total
£m</td><td>At FVTPL
£m</td><td>Amortised
cost
£m</td><td>Financial
instruments
£m</td><td>Non-
financial
instruments
£m</td><td>Total
£m</td></tr><tr><td>Trade and other payables
(Note 29)</td><td>-</td><td>(14,065)</td><td>(14,065)</td><td>(2,198)</td><td>(16,263)</td><td>-</td><td>(15,431)</td><td>(15,431)</td><td>(2,123)</td><td>(17,554)</td></tr><tr><td>Other provisions
(Note 32)</td><td>-</td><td>(63)</td><td>(63)</td><td>(1,121)</td><td>(1,184)</td><td>-</td><td>(113)</td><td>(113)</td><td>(1,358)</td><td>(1,471)</td></tr><tr><td>Contingent consideration
liabilities (Note 33)</td><td>(7,068)</td><td>-</td><td>(7,068)</td><td>-</td><td>(7,068)</td><td>(6,076)</td><td>-</td><td>(6,076)</td><td>-</td><td>(6,076)</td></tr><tr><td>Other non-current
liabilities (Note 34)</td><td>-</td><td>(84)</td><td>(84)</td><td>(815)</td><td>(899)</td><td>-</td><td>(52)</td><td>(52)</td><td>(869)</td><td>(921)</td></tr><tr><td></td><td>(7,068)</td><td>(14,212)</td><td>(21,280)</td><td>(4,134)</td><td>(25,414)</td><td>(6,076)</td><td>(15,596)</td><td>(21,672)</td><td>(4,350)</td><td>(26,022)</td></tr></table>

## (d) Derivative financial instruments and hedging programmes

Derivatives are only used for economic hedging purposes and not as speculative investments and are classified as 'held for trading'; other than designated and effective hedging instruments, and are presented as current assets or liabilities if they are expected to be settled within 12 months after the end of the reporting period, otherwise they are classified as non-current. The Group has the following derivative financial instruments:

<table><tr><td rowspan="2"></td><td colspan="3">2022</td><td colspan="2">2021</td></tr><tr><td>Fair value</td><td>Liabilities</td><td>Assets</td><td>Liabilities</td><td>Fair value</td></tr><tr><td>Non-current</td><td>Assets</td><td>Liabilities</td><td>Assets</td><td>Liabilities</td><td>Fair value</td></tr><tr><td>Cash flow hedges - Interest rate swap contracts (principal amount - £nil (2021: £1,996 million))</td><td>-</td><td>-</td><td>12</td><td>(1)</td><td></td></tr><tr><td>Current</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Cash flow hedges - Foreign exchange contracts (principal amount - £167 million (2021: £160 million))</td><td>5</td><td>-</td><td>-</td><td>(3)</td><td></td></tr><tr><td>Net investment hedges - Foreign exchange contracts (principal amount - £7,197 million (2021: £5,469 million))</td><td>20</td><td>(106)</td><td>111</td><td>(53)</td><td></td></tr><tr><td>Derivatives designated and effective as hedging instruments</td><td>25</td><td>(106)</td><td>123</td><td>(57)</td><td></td></tr><tr><td>Non-current</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Embedded and other derivatives</td><td>-</td><td>-</td><td>6</td><td>-</td><td></td></tr><tr><td>Current</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Foreign exchange contracts (principal amount - £5,908 million (2021: £9,728 million))</td><td>163</td><td>(76)</td><td>77</td><td>(169)</td><td></td></tr><tr><td>Embedded and other derivatives</td><td>2</td><td>(1)</td><td>-</td><td>(2)</td><td></td></tr><tr><td>Derivatives classified as held for trading</td><td>165</td><td>(77)</td><td>83</td><td>(171)</td><td></td></tr><tr><td>Total derivative instruments</td><td>190</td><td>(183)</td><td>206</td><td>(228)</td><td></td></tr></table>



## Notes to the financial statements continued

## 44. Financial instruments and related disclosures continued

## Fair value hedges

At 31 December 2022 and 31 December 2021, the Group had no designated fair value hedges.

## Net investment hedges

At 31 December 2022, certain foreign exchange contracts were designated as net investment hedges in respect of the foreign currency translation risk arising on consolidation of the Group’s net investment in its European (Euro), Singaporean (SGD), Canadian (CAD) and Japanese (JPY) foreign operations as shown in the table above.

The carrying value of bonds on page 249 included £6,322 million (2021: £4,982 million) that were designated as hedging instruments in net investment hedges.

## Cash flow hedges

During 2021 and 2022, the Group entered into forward foreign exchange contracts which have been designated as cash flow hedges. These were entered into to hedge the foreign exchange exposure arising on cash flows from Euro denominated coupon payments relating to notes issued under the Group’s European Medium Term Note programme, and to hedge foreign currency payments due on collaboration or licensing arrangements.

The Group manages its cash flow interest rate risk by using floating-to-fixed interest rate swaps. In addition, the Group carries a balance in reserves that arose from pre-hedging fluctuations in long-term interest rates when pricing bonds issued in prior years and in the current year. The balance is reclassified to finance costs over the life of these bonds.

## Foreign exchange risk

In the current year, the Group has designated certain foreign exchange forward contracts and swaps as cash flow and net investment hedges. Foreign exchange derivative financial assets and liabilities are presented in the line 'Derivative financial instruments' (either as assets or liabilities) on the Consolidated balance sheet. The following tables detail the foreign exchange forward contracts and swaps outstanding at the end of the reporting period, as well as information on the related hedged items.

Hedge effectiveness is determined at the inception of the hedge relationship, and through periodic prospective effectiveness assessments to ensure that an economic relationship exists between the hedged item and hedging instrument. The Group enters into hedge relationships where the critical terms of the hedging instrument match exactly with the terms of the hedged item, and so a qualitative assessment of effectiveness is performed. If changes in circumstances affect the terms of the hedged item such that the critical terms no longer match exactly with the critical terms of the hedging instrument, the Group uses the hypothetical derivative method to assess effectiveness.

The main source of hedge ineffectiveness in these hedging relationships is the effect of the counterparty and the Group’s own credit risk on the fair value of the foreign exchange forward contracts and swaps, which is not reflected in the fair value of the hedged item attributable to changes in foreign exchange rates and ineffectiveness on rolling the cash flow hedges of the divestments mentioned above. No other sources of ineffectiveness emerged from these hedging relationships. No ineffectiveness was recorded from cash flow hedges in 2022 (2021: £nil). No ineffectiveness was recorded from net investment hedges (2021: £nil).

<table><tr><td>Hedging instruments</td><td>Average exchange rate</td><td>Foreign currency</td><td>Notional value £m</td><td>Carrying value £m</td><td>Periodic change in value for calculating hedge ineffectiveness £m</td></tr><tr><td>Cash flow hedges</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Foreign exchange contracts</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Buy foreign currency:</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Less than 3 months</td><td>1.23</td><td>USD</td><td>100</td><td>2</td><td>2</td></tr><tr><td>3 to 6 months</td><td>1.16</td><td>EUR</td><td>50</td><td>2</td><td>2</td></tr><tr><td>Over 6 months</td><td>1.15</td><td>EUR</td><td>24</td><td>1</td><td>1</td></tr><tr><td>Sell foreign currency</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Less than 3 months</td><td>1.14</td><td>EUR</td><td>(7)</td><td>-</td><td>-</td></tr><tr><td></td><td></td><td></td><td>167</td><td>5</td><td>5</td></tr></table>



## Notes to the financial statements continued

## 44. Financial instruments and related disclosures continued

<table><tr><td></td><td></td><td></td><td></td><td></td><td></td><td>2022</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr></table>



## Notes to the financial statements continued

## 44. Financial instruments and related disclosures continued

<table><tr><td></td><td></td><td></td><td></td><td></td><td></td><td>2021</td></tr><tr><td></td><td></td><td></td><td></td><td>Periodic change in value for calculating hedge ineffectiveness</td><td>Cumulative balance in cash flow hedge reserve/foreign currency translation reserve for continuing hedges</td><td></td></tr><tr><td>Hedged items</td><td></td><td></td><td></td><td>£m</td><td>£m</td><td></td></tr><tr><td>Cash flow hedges</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Variability in cash flows from foreign exchange exposure arising on Euro denominated coupon payments relating to debt issued</td><td></td><td></td><td></td><td>1</td><td>(1)</td><td></td></tr><tr><td>Net investment hedges</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Net investment in foreign operations</td><td></td><td></td><td></td><td>(1117)</td><td></td><td>(873)</td></tr></table>

£3 million (2021: £19 million) of balances in the cash flow hedge reserve arise from hedging relationships for which hedge accounting is no longer applied.

The following table details the effectiveness of the hedging relationships and the amounts reclassified from the hedging reserve to profit or loss:

<table><tr><td rowspan="2"></td><td colspan="7">Amount reclassified to profit or loss</td></tr><tr><td>Hedging gains/(losses) recognised in reserves £m</td><td>Amount of hedge ineffectiveness recognised in profit or loss £m</td><td>Line item in profit or loss in which hedge ineffectiveness is included</td><td>Hedged future cash flows no longer expected to occur £m</td><td>Due to hedged item affecting profit or loss £m</td><td>Line item in profit or loss in which reclassification adjustment is included</td><td>2022 Amount reclassified to balance sheet £m</td></tr><tr><td>Cash flow hedges</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Variability in cash flows from a highly probable forecast transaction</td><td>(5)</td><td>-</td><td>Finance income or expense</td><td>-</td><td>-</td><td>-</td><td>8 Intangible assets</td></tr><tr><td>Variability in cash flows from foreign exchange exposure arising on Euro denominated coupon payments relating to debt issued</td><td>4</td><td>-</td><td>Finance income or expense</td><td>-</td><td>(2)</td><td>Finance income or expense</td><td>-</td></tr><tr><td>Net investment hedges</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Net investment in foreign operations</td><td>(617)</td><td>-</td><td>Finance income or expense</td><td>-</td><td>194</td><td>Discontinued operations(1)</td><td>-</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>2021 Amount reclassified to balance sheet £m</td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td>Hedging gains/(losses) recognised in reserves £m</td><td>Amount of hedge ineffectiveness recognised in profit or loss £m</td><td>Line item in profit or loss in which hedge ineffectiveness is included</td><td>Hedged future cash flows no longer expected to occur £m</td><td>Due to hedged item affecting profit or loss £m</td><td>Line item in profit or loss in which reclassification adjustment is included</td><td>Line item in balance sheet in which reclassification adjustment is included</td></tr><tr><td>Cash flow hedges</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Variability in cash flows from a highly probable forecast transaction</td><td>7</td><td>-</td><td>Other operating income/(expense)</td><td>-</td><td>(7)</td><td>Other operating income/(expense)</td><td>-</td></tr><tr><td>Variability in cash flows from foreign exchange exposure arising on Euro denominated coupon payments relating to debt issued</td><td>(1)</td><td>-</td><td>Finance income or expense</td><td>-</td><td>-</td><td>Finance income or expense</td><td>-</td></tr><tr><td>Net investment hedges</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Net investment in foreign operations</td><td>1,117</td><td>-</td><td>Finance income or expense</td><td>-</td><td>(7)</td><td>Finance income or expense</td><td>-</td></tr></table>

(1) Reclassified to the Consolidated income statement on the demerger of the Consumer Healthcare business.



## Notes to the financial statements continued

## 44. Financial instruments and related disclosures continued

## Interest rate risk

The Group manages its cash flow interest rate risk by using floating-to-fixed interest rate swaps, where at quarterly intervals the difference between fixed contract rates and floating rate interest amounts calculated by reference to the agreed notional principal amounts are exchanged.

There are none of these swaps outstanding at 31 December 2022. At 31 December 2021, the interest rate risk on an element of future debt issuance had been managed by entering into forward starting interest rate swaps, effectively to lock in the interest rates on the debt in advance. These were closed out at the time of issuing the debt, and the resulting gain or loss held in the Cash flow hedge reserve and reclassified to income statement as the interest payments on the debt impacted the income statement until the debt was derecognised on demerger of the Consumer Healthcare business in July 2022.

## Forward starting interest rate swaps

The forward starting interest rate contracts, exchanging floating interest for fixed interest, were designated as cash flow hedges to hedge the interest variability of the interest cash flows associated with the future fixed rate debt.

## Interest rate swaps

The following tables provide information regarding interest rate swap and forward starting interest rate swap contracts outstanding and the related hedged items at 31 December 2021. There were no such swaps at 31 December 2022. Interest rate swap contract assets and liabilities are presented in the line 'Derivative financial instruments' (either as assets or liabilities) on the Consolidated balance sheet.

£24 million (2021: £11 million) of balances in the cash flow hedge reserve arise from hedge relationships for which hedge accounting is no longer applied.

<table><tr><td rowspan="2"></td><td colspan="4">2021</td></tr><tr><td>Average contracted fixed rate %</td><td>Notional principal value £m</td><td>Change in fair value for recognising hedge ineffectiveness £m</td><td>Fair value assets/(liabilities) £m</td></tr><tr><td>Hedging instruments</td><td></td><td></td><td></td><td></td></tr><tr><td>5-10 years</td><td>11038</td><td>668</td><td>4</td><td>4</td></tr><tr><td>10-30 years</td><td>13385</td><td>935</td><td>3</td><td>3</td></tr><tr><td>More than 30 years</td><td>14515</td><td>393</td><td>4</td><td>4</td></tr><tr><td></td><td></td><td></td><td></td><td>2021</td></tr><tr><td></td><td></td><td></td><td></td><td>Balance in cash flow hedge reserve for continuing hedges after tax £m</td></tr><tr><td>Hedged items</td><td></td><td></td><td></td><td></td></tr><tr><td>Pre-hedging of long-term interest rate</td><td></td><td></td><td>(11)</td><td>(8)</td></tr></table>



## Notes to the financial statements continued

## 44. Financial instruments and related disclosures continued

The following table details the effectiveness of the hedging relationships and the amounts reclassified from the hedging reserve to profit or loss:

<table><tr><td rowspan="2"></td><td colspan="6">2022</td></tr><tr><td colspan="3">Amount reclassified to profit or loss</td><td colspan="3">Amount reclassified to profit or loss</td></tr><tr><td></td><td>Line item in profit or loss in which hedge is included</td><td>Line item in profit or loss in which hedge is included</td><td>Line item in profit in which hedge is included</td><td>Line item in profit or loss in which hedge is included</td><td></td><td></td></tr><tr><td>Cash flow hedges</td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Pre-hedging of long-term interest rates:</td><td></td><td></td><td>Finance income or expense</td><td>-</td><td>3</td><td>Finance income or expense</td></tr><tr><td>Matured in the past</td><td>(23)</td><td>-</td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr></table>

## (e) Offsetting of financial assets and liabilities

Financial assets and liabilities are offset and the net amount reported in the balance sheet where there is a legally enforceable right to offset the recognised amounts, and there is an intention to settle on a net basis or realise the asset and settle the liability simultaneously. There are also arrangements that do not meet the criteria for offsetting but still allow for the related amounts to be offset in certain circumstances, such as bankruptcy or the termination of a contract.

The following tables set out the financial assets and liabilities that are offset, or subject to enforceable master netting arrangements and other similar agreements but not offset, as at 31 December 2022 and 31 December 2021. The column ‘Net amount’ shows the impact on the Group’s balance sheet if all offset rights were exercised.

<table><tr><td>At 31 December 2022</td><td>Gross financial assets/(liabilities) £m</td><td>Gross financial liabilities/(assets set off) £m</td><td>Net financial assets/(liabilities) per balance sheet £m</td><td>Related amounts not set off in the balance sheet £m</td><td>Net £m</td></tr><tr><td>Financial assets</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Trade and other receivables</td><td>6,166</td><td>-</td><td>6,166</td><td>-</td><td>6,166</td></tr><tr><td>Derivative financial instruments</td><td>190</td><td>-</td><td>190</td><td>(163)</td><td>27</td></tr><tr><td>Financial liabilities</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Trade and other payables</td><td>(14,065)</td><td>-</td><td>(14,065)</td><td>-</td><td>(14,065)</td></tr><tr><td>Derivative financial instruments</td><td>(183)</td><td>-</td><td>(183)</td><td>163</td><td>(20)</td></tr></table>



## Notes to the financial statements continued

## 44. Financial instruments and related disclosures continued

<table><tr><td>At 31 December 2021</td><td>Gross financial assets/ (liabilities) £m</td><td>Financial (liabilities)/ assets offset £m</td><td>Net financial assets/ (liabilities) £m</td><td>Related amounts not offset £m</td><td>Net balance £m</td></tr><tr><td>Financial assets</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Trade and other receivables</td><td>6,851</td><td>(19)</td><td>6,832</td><td>(3)</td><td>6,829</td></tr><tr><td>Derivative financial instruments</td><td>206</td><td>-</td><td>206</td><td>(192)</td><td>14</td></tr><tr><td>Financial liabilities</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Trade and other payables</td><td>(15,450)</td><td>19</td><td>(15,431)</td><td>3</td><td>(15,428)</td></tr><tr><td>Derivative financial instruments</td><td>(228)</td><td>-</td><td>(228)</td><td>192</td><td>(36)</td></tr></table>

Amounts which do not meet the criteria for offsetting on the balance sheet but could be settled net in certain circumstances principally relate to derivative transactions under ISDA (International Swaps and Derivatives Association) agreements where each party has the option to settle amounts on a net basis in the event of default of the other party. As there is presently not a legally enforceable right of offset, these amounts have not been offset in the balance sheet, but have been presented separately in the table above.

## (f) Debt interest rate repricing table

The following table sets out the exposure of the Group to interest rates on debt, including commercial paper. The maturity analysis of fixed rate debt is stated by contractual maturity and of floating rate debt by interest rate repricing dates. For the purpose of this table, debt is defined as all classes of borrowings other than lease liabilities.

<table><tr><td></td><td>2022</td><td>2021</td></tr><tr><td></td><td>Total debt £m</td><td>Total £m</td></tr><tr><td>Floating and fixed rate debt less than one year</td><td>(3,785)</td><td>(3,398)</td></tr><tr><td>Between one and two years</td><td>(1,714)</td><td>(4,030)</td></tr><tr><td>Between two and three years</td><td>(1,490)</td><td>(1,576)</td></tr><tr><td>Between three and four years</td><td>(1,505)</td><td>(1,365)</td></tr><tr><td>Between four and five years</td><td>(748)</td><td>(1,425)</td></tr><tr><td>Between five and ten years</td><td>(4,736)</td><td>(4,411)</td></tr><tr><td>Greater than ten years</td><td>(6,001)</td><td>(6,953)</td></tr><tr><td>Total</td><td>(19979)</td><td>(23158)</td></tr><tr><td>Original issuance profile:</td><td></td><td></td></tr><tr><td>Fixed rate interest</td><td>(18,355)</td><td>(22,355)</td></tr><tr><td>Floating rate interest</td><td>(1,624)</td><td>(803)</td></tr><tr><td></td><td>(19979)</td><td>(23158)</td></tr></table>



## Notes to the financial statements continued

## 44. Financial instruments and related disclosures continued

## (g) Sensitivity analysis

The tables below illustrate the estimated impact on the income statement and equity as a result of hypothetical market movements in foreign exchange and interest rates in relation to the Group’s financial instruments. The range of variables chosen for the sensitivity analysis reflects management’s view of changes which are reasonably possible over a one-year period.

## Foreign exchange sensitivity

The Group operates internationally and is primarily exposed to foreign exchange risk in relation to Sterling against movements in US Dollar, Euro and Japanese Yen. Foreign exchange risk arises from the translation of financial assets and liabilities which are not in the functional currency of the entity that holds them. Based on the Group’s net financial assets and liabilities as at 31 December, a weakening and strengthening of Sterling against these currencies, with all other variables held constant, is illustrated in the tables below. The tables exclude financial instruments that expose the Group to foreign exchange risk where this risk is fully hedged with another financial instrument.

<table><tr><td rowspan="2"></td><td colspan="2">2022</td><td rowspan="2">2021</td></tr><tr><td>Increase/(decrease) in income</td><td>Increase/(decrease) in income</td></tr><tr><td>Income statement impact of non-functional currency foreign exchange exposures</td><td>£m</td><td>£m</td><td>£m</td></tr><tr><td>10 cent appreciation of the US Dollar</td><td>99</td><td>5</td><td></td></tr><tr><td>15 cent appreciation of the US Dollar</td><td>155</td><td>8</td><td></td></tr><tr><td>10 cent appreciation of the Euro</td><td>(7)</td><td>(26)</td><td></td></tr><tr><td>15 cent appreciation of the Euro</td><td>(12)</td><td>(41)</td><td></td></tr><tr><td>10 yen appreciation of the Yen</td><td>-</td><td>-</td><td></td></tr><tr><td>15 yen appreciation of the Yen</td><td>(1)</td><td>-</td><td></td></tr></table>

<table><tr><td rowspan="2"></td><td colspan="2">2022</td><td rowspan="2">2021</td></tr><tr><td>Increase/(decrease) in income</td><td>Increase/(decrease) in income</td></tr><tr><td>Income statement impact of non-functional currency foreign exchange exposures</td><td>£m</td><td>£m</td><td>£m</td></tr><tr><td>10 cent depreciation of the US Dollar</td><td>(84)</td><td>(4)</td><td></td></tr><tr><td>15 cent depreciation of the US Dollar</td><td>(121)</td><td>(6)</td><td></td></tr><tr><td>10 cent depreciation of the Euro</td><td>6</td><td>22</td><td></td></tr><tr><td>15 cent depreciation of the Euro</td><td>9</td><td>32</td><td></td></tr><tr><td>10 yen depreciation of the Yen</td><td>-</td><td>-</td><td></td></tr><tr><td>15 yen depreciation of the Yen</td><td>-</td><td>-</td><td></td></tr></table>

The equity impact, shown below, for foreign exchange sensitivity relates to derivative and non-derivative financial instruments hedging the Group’s net investments in its European (Euro) foreign operations and cash flow hedges of its foreign exchange exposure arising on Euro denominated coupon payments relating to notes issued under the Group’s European Medium Term Note programme.

<table><tr><td rowspan="2"></td><td colspan="2">2022</td><td rowspan="2">2021</td></tr><tr><td>Increase/(decrease) in equity</td><td>Increase/(decrease) in equity</td></tr><tr><td>Equity impact of non-functional currency foreign exchange exposures</td><td>£m</td><td>£m</td><td>£m</td></tr><tr><td>10 cent appreciation of the Euro</td><td>(1,290)</td><td>(964)</td><td></td></tr><tr><td>15 cent appreciation in Euro</td><td>(2,034)</td><td>(1,515)</td><td></td></tr></table>

<table><tr><td rowspan="2"></td><td colspan="2">2022</td><td rowspan="2">2021</td></tr><tr><td>Increase/(decrease) in equity</td><td>Increase/(decrease) in equity</td></tr><tr><td>Equity impact of non-functional currency foreign exchange exposures</td><td>£m</td><td>£m</td><td>£m</td></tr><tr><td>10 cent depreciation of the Euro</td><td>1,080</td><td>814</td><td></td></tr><tr><td>15 cent depreciation of the Euro</td><td>1,557</td><td>1,176</td><td></td></tr></table>



## Notes to the financial statements continued

## 44. Financial instruments and related disclosures continued

The tables below present the Group’s sensitivity to a weakening and strengthening of Sterling against the relevant currency based on the composition of net debt as shown in Note 30 adjusted for the effects of foreign exchange derivatives that are not part of net debt but affect future foreign currency cash flows.

<table><tr><td rowspan="2"></td><td colspan="2">2022</td><td>2021</td></tr><tr><td>(Increase)/decrease in net debt</td><td>(Increase)/decrease in net debt</td><td></td></tr><tr><td>Impact of foreign exchange movements on net debt</td><td>£m</td><td>£m</td><td></td></tr><tr><td>10 cent appreciation of the US Dollar</td><td>(999)</td><td>(767)</td><td></td></tr><tr><td>15 cent appreciation of the US Dollar</td><td>(1,570)</td><td>(1,199)</td><td></td></tr><tr><td>10 cent appreciation of the Euro</td><td>11</td><td>444</td><td></td></tr><tr><td>15 cent appreciation of the Euro</td><td>17</td><td>698</td><td></td></tr><tr><td>10 yen appreciation of the Yen</td><td>13</td><td>17</td><td></td></tr><tr><td>15 yen appreciation of the Yen</td><td>20</td><td>26</td><td></td></tr></table>

<table><tr><td rowspan="2"></td><td colspan="2">2022</td><td>2021</td></tr><tr><td>(Increase)/decrease in net debt</td><td>(Increase)/decrease in net debt</td><td></td></tr><tr><td>Impact of foreign exchange movements on net debt</td><td>£m</td><td>£m</td><td></td></tr><tr><td>10 cent depreciation of the US Dollar</td><td>846</td><td>661</td><td></td></tr><tr><td>15 cent depreciation of the US Dollar</td><td>1,222</td><td>959</td><td></td></tr><tr><td>10 cent depreciation of the Euro</td><td>(9)</td><td>(375)</td><td></td></tr><tr><td>15 cent depreciation of the Euro</td><td>(13)</td><td>(542)</td><td></td></tr><tr><td>10 yen depreciation of the Yen</td><td>(12)</td><td>(15)</td><td></td></tr><tr><td>15 yen depreciation of the Yen</td><td>(17)</td><td>(21)</td><td></td></tr></table>

## Interest rate sensitivity

The Group is exposed to interest rate risk on its outstanding borrowings and investments where any changes in interest rates will affect future cash flows or the fair values of financial instruments.

The majority of debt is issued at fixed interest rates and changes in the floating rates of interest do not significantly affect the Group’s net interest charge, although the majority of cash and liquid investments earn floating rates of interest.

The table below hypothetically shows the Group’s sensitivity to changes in interest rates in relation to Sterling, US Dollar and Euro floating rate financial assets and liabilities. A 1% (100 basis points) movement in USD interest rates would cause an increase of £nil to equity (2021: £197 million). A 1.5% (150 basis points) movement in USD interest rates would cause an increase of £nil to equity (2021: £297 million). A 1% (100 basis points) or 1.5% (150 basis points) movement in EUR or Sterling interest rates is not deemed to have a material effect on equity.

<table><tr><td rowspan="2"></td><td colspan="2">2022</td><td>2021</td></tr><tr><td>Increase/(decrease) in income</td><td>Increase/(decrease) in income</td><td></td></tr><tr><td>Income statement impact of interest rate movements</td><td>£m</td><td>£m</td><td></td></tr><tr><td>1% (100 basis points) increase in Sterling interest rates</td><td>36</td><td>(25)</td><td></td></tr><tr><td>1.5% (150 basis points) increase in Sterling interest rates</td><td>55</td><td>(38)</td><td></td></tr><tr><td>1% (100 basis points) increase in US Dollar interest rates</td><td>(34)</td><td>11</td><td></td></tr><tr><td>1.5% (150 basis points) increase in US Dollar interest rates</td><td>(51)</td><td>17</td><td></td></tr><tr><td>1% (100 basis points) increase in Euro interest rates</td><td>(13)</td><td>3</td><td></td></tr><tr><td>1.5% (150 basis points) increase in Euro interest rates</td><td>(19)</td><td>5</td><td></td></tr></table>



## Notes to the financial statements continued

## 44. Financial instruments and related disclosures continued

## (h) Contractual cash flows for non-derivative financial liabilities and derivative instruments

The following tables provide an analysis of the anticipated contractual cash flows including interest payable for the Group’s non-derivative financial liabilities on an undiscounted basis. For the purpose of this table, debt is defined as all classes of borrowings except for lease liabilities. Interest is calculated based on debt held at 31 December without taking account of future issuance. Floating rate interest is estimated using the prevailing interest rate at the balance sheet date. Cash flows in foreign currencies are translated using spot rates at 31 December.

<table><tr><td>At 31 December 2022</td><td>Debt
£m</td><td>Interest
on debt
£m</td><td>Lease
liabilities
£m</td><td>Finance
charge
on lease
liabilities
£m</td><td>Trade payables
and other
liabilities not
in net debt
£m</td><td>Total
£m</td></tr><tr><td>Due in less than one year</td><td>(3,786)</td><td>(594)</td><td>(167)</td><td>(25)</td><td>(15,362)</td><td>(19934)</td></tr><tr><td>Between one and two years</td><td>(1,717)</td><td>(570)</td><td>(201)</td><td>(22)</td><td>(1,097)</td><td>(3,607)</td></tr><tr><td>Between two and three years</td><td>(1,496)</td><td>(531)</td><td>(127)</td><td>(19)</td><td>(1,034)</td><td>(3,207)</td></tr><tr><td>Between three and four years</td><td>(1,508)</td><td>(489)</td><td>(97)</td><td>(15)</td><td>(1,277)</td><td>(3,386)</td></tr><tr><td>Between four and five years</td><td>(751)</td><td>(472)</td><td>(80)</td><td>(13)</td><td>(1,008)</td><td>(2,324)</td></tr><tr><td>Between five and ten years</td><td>(4,765)</td><td>(1,810)</td><td>(201)</td><td>(41)</td><td>(2,641)</td><td>(9,458)</td></tr><tr><td>Greater than ten years</td><td>(6,063)</td><td>(1,856)</td><td>(135)</td><td>(11)</td><td>(1,134)</td><td>(9,199)</td></tr><tr><td>Gross contractual cash flows</td><td>(20,086)</td><td>(6,322)</td><td>(1,008)</td><td>(146)</td><td>(23,553)</td><td>(51,115)</td></tr><tr><td>At 31 December 2021</td><td>Debt
£m</td><td>Interest
on debt
£m</td><td>Lease
liabilities
£m</td><td>Finance
charge
on lease
liabilities
£m</td><td>Trade payables
and other
liabilities not
in net debt
£m</td><td>Total
£m</td></tr><tr><td>Due in less than one year</td><td>(3,399)</td><td>(686)</td><td>(203)</td><td>(25)</td><td>(16,432)</td><td>(20,745)</td></tr><tr><td>Between one and two years</td><td>(4,042)</td><td>(620)</td><td>(185)</td><td>(22)</td><td>(935)</td><td>(5,804)</td></tr><tr><td>Between two and three years</td><td>(1,582)</td><td>(574)</td><td>(120)</td><td>(19)</td><td>(893)</td><td>(3,188)</td></tr><tr><td>Between three and four years</td><td>(1,372)</td><td>(538)</td><td>(93)</td><td>(16)</td><td>(919)</td><td>(2,938)</td></tr><tr><td>Between four and five years</td><td>(1,428)</td><td>(500)</td><td>(73)</td><td>(14)</td><td>(924)</td><td>(2,939)</td></tr><tr><td>Between five and ten years</td><td>(4,440)</td><td>(2,046)</td><td>(205)</td><td>(44)</td><td>(2,703)</td><td>(9,438)</td></tr><tr><td>Greater than ten years</td><td>(7,033)</td><td>(2,639)</td><td>(136)</td><td>(13)</td><td>(1,571)</td><td>(11,392)</td></tr><tr><td>Gross contractual cash flows</td><td>(23,296)</td><td>(7,603)</td><td>(1,015)</td><td>(153)</td><td>(24,377)</td><td>(56,444)</td></tr></table>

The table below provides an analysis of the anticipated contractual cash flows for the Group’s derivative instruments excluding equity options which do not give rise to cash flows, and other embedded derivatives, which are not material, using undiscounted cash flows. Cash flows in foreign currencies are translated using spot rates at 31 December. The gross cash flows of foreign exchange contracts are presented for the purpose of this table although, in practice, the Group uses standard settlement arrangements to reduce its liquidity requirements on these instruments.

<table><tr><td rowspan="3"></td><td colspan="8">2022</td></tr><tr><td colspan="2">Gross cash inflows</td><td colspan="2">Gross cash outflows</td><td colspan="2">Gross cash inflows</td><td colspan="2">Gross cash outflows</td></tr><tr><td>Forward starting interest rate swaps £m</td><td>Foreign exchange forward contracts and swaps £m</td><td>Forward starting interest rate swaps £m</td><td>Foreign exchange forward contracts and swaps £m</td><td>Foreward starting interest rate swaps £m</td><td>Foreign exchange forward contracts and swaps £m</td><td>Forward starting interest rate swaps £m</td><td>Foreign exchange forward contracts and swaps £m</td></tr><tr><td>Less than one year</td><td>-</td><td>24,418</td><td>-</td><td>(24,410)</td><td>-</td><td>41,252</td><td>(13)</td><td>(41,290)</td></tr><tr><td>Between one and two years</td><td>-</td><td>-</td><td>-</td><td>-</td><td>12</td><td>-</td><td>(26)</td><td>-</td></tr><tr><td>Between two and three years</td><td>-</td><td>-</td><td>-</td><td>-</td><td>24</td><td>-</td><td>(26)</td><td>-</td></tr><tr><td>Between three and four years</td><td>-</td><td>-</td><td>-</td><td>-</td><td>28</td><td>-</td><td>(26)</td><td>-</td></tr><tr><td>Between four and five years</td><td>-</td><td>-</td><td>-</td><td>-</td><td>28</td><td>-</td><td>(26)</td><td>-</td></tr><tr><td>Greater than five years</td><td>-</td><td>-</td><td>-</td><td>-</td><td>259</td><td>-</td><td>(220)</td><td>-</td></tr><tr><td>Gross contractual cash flows</td><td>-</td><td>24,418</td><td>-</td><td>(24,410)</td><td>351</td><td>41,252</td><td>(337)</td><td>(41,290)</td></tr></table>



## 45. Employee share schemes

GSK operates several employee share schemes, including the Share Value Plan, whereby awards are granted to employees to acquire shares or ADS in GSK plc at no cost after a three-year vesting period and the Performance Share Plan, whereby awards are granted to employees to acquire shares or ADS in GSK plc at no-cost, subject to the achievement by the Group of specified performance targets. The granting of these restricted share awards has replaced the granting of options to employees as the cost of the schemes more readily equates to the potential gain to be made by the employee. The Group also operates savings related share option schemes, whereby options are granted to employees to acquire shares in GSK plc at a discounted price.

Grants of restricted share awards are normally exercisable at the end of the three-year vesting or performance period. Awards are normally granted to employees to acquire shares or ADS in GSK plc but in some circumstances may be settled in cash. Grants under savings-related share option schemes are normally exercisable after three years' saving. In accordance with UK practice, the majority of options under the savings-related share option schemes are granted at a price 20% below the market price ruling at the date of grant. Options under historical share option schemes were granted at the market price ruling at the date of grant.

The value of the plans for participating employees has been maintained after the demerger of the Consumer Healthcare business through the effect of the share consolidation (see Note 37). The total charge for share-based incentive plans in 2022 was £314 million (2021 \( ^{(1)} $ : £345 million; 2020 \( ^{(1)} $ : £330 million). Of this amount, £243 million (2021 \( ^{(1)} $ : £258 million; 2020 \( ^{(1)} $ : £266 million) arose from the Share Value Plan. See Note 9, 'Employee Costs' for further details.

(1) The 2021 and 2020 comparatives have been restated to reflect on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business. See Note 41.

## GSK share award schemes

## Share Value Plan

Under the Share Value Plan, share awards are granted to certain employees at no cost. The awards vest after two and a half to three years and there are no performance criteria attached. The fair value of these awards is determined based on the closing share price on the day of grant, after deducting the expected future dividend yield of 3.2% (2021: 3.8%; 2020: 5.0%) over the duration of the award.

<table><tr><td>Number of shares and ADS issuable</td><td>Shares \( ^{(1)} \)  Number (000)</td><td>Weighted fair value</td><td>ADS \( ^{(1)} \)  Number (000)</td><td>Weighted fair value</td></tr><tr><td>At 1 January 2020</td><td>29459</td><td></td><td>15,850</td><td></td></tr><tr><td>Awards granted</td><td>11115</td><td>£13.58</td><td>6,633</td><td>$34.43</td></tr><tr><td>Awards exercised</td><td>(10,284)</td><td></td><td>(5,353)</td><td></td></tr><tr><td>Awards cancelled</td><td>(1,416)</td><td></td><td>(1,014)</td><td></td></tr><tr><td>At 31 December 2020</td><td>28,874</td><td></td><td>16,116</td><td></td></tr><tr><td>Awards granted</td><td>11,220</td><td>£13.28</td><td>6,358</td><td>$36.68</td></tr><tr><td>Awards exercised</td><td>(10,074)</td><td></td><td>(5,240)</td><td></td></tr><tr><td>Awards cancelled</td><td>(1,776)</td><td></td><td>(1,705)</td><td></td></tr><tr><td>At 31 December 2021</td><td>28,244</td><td></td><td>15,529</td><td></td></tr><tr><td>Awards granted</td><td>10,987</td><td>£13.00</td><td>6,133</td><td>$30.64</td></tr><tr><td>Awards exercised</td><td>(9,538)</td><td></td><td>(4,919)</td><td></td></tr><tr><td>Awards cancelled</td><td>(1,718)</td><td></td><td>(1,314)</td><td></td></tr><tr><td>At 31 December 2022</td><td>27975</td><td></td><td>15,429</td><td></td></tr></table>

(1) The 2021 and 2020 comparatives have been restated to reflect the demerger of the Consumer Healthcare business and aid year on year volume comparability of awards granted to GSK employees.

## Performance Share Plan

Under the Performance Share Plan, share awards are granted to Directors and senior executives at no cost. The percentage of each award that vests is based upon the performance of the Group over a defined measurement period with dividends reinvested during the same period. For awards granted from 2016 to 2019, the performance conditions are based on three equally weighted measures over a three-year performance period. These were adjusted free cash flow, TSR and R&D new product performance. For awards granted from 2020, the performance conditions are based on four measures over a three-year performance period. These are adjusted free cash flow (30%), TSR (30%), R&D new product performance (20%) and pipeline progress (20%). For awards granted from 2022, the performance conditions are based on five measures over a three-year performance period. These are TSR (30%), pipeline progress (20%), profit measure (20%), sale measure (20%) and ESG environment (10%).

The fair value of the awards is determined based on the closing share price on the day of grant. For TSR performance elements, this is adjusted by the likelihood of that condition being met, as assessed at the time of grant.

During 2022, awards for the continuing business were made of 4.0 million shares at a weighted fair value of £13.36 and 1.0 million ADS at a weighted fair value of $35.88. At 31 December 2022, there were outstanding awards over 12.6 million shares and 2.8 million ADS.



## Notes to the financial statements continued

## 45. Employee share schemes continued

## Share options and savings-related options

For the purposes of valuing savings-related options to arrive at the share-based payment charge, a Black-Scholes option pricing model has been used. The assumptions used in the model are as follows:

<table><tr><td></td><td>2022 Grant</td><td>2021 Grant</td><td>2020 Grant</td></tr><tr><td>Risk-free interest rate</td><td>3.37%</td><td>0.74%</td><td>(0.07)%</td></tr><tr><td>Dividend yield</td><td>3.3%</td><td>3.8%</td><td>6.2%</td></tr><tr><td>Volatility</td><td>36%</td><td>27%</td><td>27%</td></tr><tr><td>Expected life</td><td>3 years</td><td>3 years</td><td>3 years</td></tr><tr><td>Savings-related options grant price (including 20% discount)</td><td>£11.39</td><td>£12.07</td><td>£10.34</td></tr></table>

<table><tr><td rowspan="2">Options outstanding for the Share Save Plan</td><td colspan="2">Savings-related share option schemes</td></tr><tr><td>Number 000</td><td>Weighted exercise price</td></tr><tr><td>At 31 December 2022</td><td>5,803</td><td>£11.38</td></tr><tr><td>Range of exercise prices on options outstanding at year end</td><td>£10.34</td><td>- £14.15</td></tr><tr><td>Weighted average market price on exercise during year</td><td></td><td>£16.15</td></tr><tr><td>Weighted average remaining contractual life</td><td></td><td>2.0 years</td></tr></table>

Options over 1.2 million shares were granted during the year under the savings-related share option scheme at a weighted average fair value of £4.34. At 31 December 2022, 5.3 million of the savings-related share options were not exercisable.

There has been no change in the effective exercise price of any outstanding options during the year.

## Employee Share Ownership Plan Trusts

The Group sponsors Employee Share Ownership Plan (ESOP) Trusts to acquire and hold shares in GSK plc to satisfy awards made under employee incentive plans and options granted under employee share option schemes. The trustees of the ESOP Trusts purchase shares with finance provided by the Group by way of loans or contributions. The costs of running the ESOP Trusts are charged to the income statement. Shares held by the ESOP Trusts are deducted from other reserves and amortised down to the value of proceeds, if any, receivable from employees on exercise by a transfer to retained earnings. The trustees have waived their rights to dividends on the shares held by the ESOP Trusts.

<table><tr><td>Shares held for share award schemes</td><td>2022</td><td>2021</td></tr><tr><td>Number of shares (000)</td><td>59,814</td><td>23,065</td></tr></table>

<table><tr><td>Nominal value</td><td>£m</td><td>£m</td></tr><tr><td>Carrying value</td><td>19</td><td>6</td></tr><tr><td>Market value</td><td>353</td><td>27</td></tr><tr><td></td><td>860</td><td>371</td></tr></table>

<table><tr><td>Shares held for share option schemes</td><td>2022</td><td>2021</td></tr><tr><td>Number of shares (000)</td><td>65</td><td>139</td></tr></table>

<table><tr><td></td><td>£m</td><td>£m</td></tr><tr><td>Nominal value</td><td>-</td><td>-</td></tr><tr><td>Carrying value</td><td>1</td><td>1</td></tr><tr><td>Market value</td><td>1</td><td>2</td></tr></table>



## 46. Principal Group companies

The following represent the principal subsidiaries and their countries of incorporation of the Group at 31 December 2022. The equity share capital of these entities is shown in the percentage columns. All companies are incorporated in their principal country of operation except where stated.

<table><tr><td>England</td><td>%</td><td>Scotland</td><td>%</td></tr><tr><td>Glaxo Group Limited</td><td>100</td><td>GSK (No.1) Scottish Limited Partnership \( ^{6} \)</td><td></td></tr><tr><td>Glaxo Operations UK Limited</td><td>100</td><td>GSK (No.2) Scottish Limited Partnership \( ^{6} \)</td><td></td></tr><tr><td>Glaxo Wellcome UK Limited</td><td>100</td><td>GSK (No.3) Scottish Limited Partnership \( ^{6} \)</td><td></td></tr><tr><td>GlaxoSmithKline Capital plc</td><td>100</td><td></td><td></td></tr><tr><td>GlaxoSmithKline Export Limited</td><td>100</td><td></td><td></td></tr><tr><td>GlaxoSmithKline Finance plc</td><td>100</td><td>Affinivax, Inc</td><td>100</td></tr><tr><td>GlaxoSmithKline Holdings Limited \( ^{6} \)</td><td>100</td><td>Corixa Corporation</td><td>100</td></tr><tr><td>GlaxoSmithKline IHC Limited</td><td>100</td><td>GlaxoSmithKline Capital Inc.</td><td>100</td></tr><tr><td>GlaxoSmithKline Intellectual Property (No.2) Limited</td><td>100</td><td>GlaxoSmithKline Holdings (Americas) Inc.</td><td>100</td></tr><tr><td>GlaxoSmithKline Intellectual Property (No.3) Limited</td><td>100</td><td>GlaxoSmithKline LLC</td><td>100</td></tr><tr><td>GlaxoSmithKline Intellectual Property (No.4) Limited</td><td>100</td><td>GSK Equity Investments, Limited</td><td>100</td></tr><tr><td>GlaxoSmithKline Intellectual Property Development Limited</td><td>100</td><td>Human Genome Sciences, Inc</td><td>100</td></tr><tr><td>GlaxoSmithKline Intellectual Property Limited</td><td>100</td><td>Stiefel Laboratories, Inc</td><td>100</td></tr><tr><td>GlaxoSmithKline Research &amp; Development Limited</td><td>100</td><td>Tesaro, Inc.</td><td>100</td></tr><tr><td>GlaxoSmithKline Services Unlimited \( ^{6} \)</td><td>100</td><td>ViIV Healthcare Company</td><td>78.3</td></tr><tr><td>GlaxoSmithKline UK Limited</td><td>100</td><td></td><td></td></tr><tr><td>GlaxoSmithKline US Trading Limited</td><td>100</td><td></td><td></td></tr><tr><td>Setfrist Limited</td><td>100</td><td></td><td></td></tr><tr><td>SmithKline Beecham Limited</td><td>100</td><td></td><td></td></tr><tr><td>ViIV Healthcare Finance Limited</td><td>78.3</td><td></td><td></td></tr><tr><td>ViIV Healthcare UK (No.3) Limited</td><td>78.3</td><td></td><td></td></tr><tr><td>ViIV Healthcare UK Limited</td><td>78.3</td><td></td><td></td></tr><tr><td>Europe</td><td>%</td><td>Others</td><td>%</td></tr><tr><td>GlaxoSmithKline AG (Switzerland)</td><td>100</td><td>Glaxo Saudi Arabia Limited (Saudi Arabia)</td><td>75</td></tr><tr><td>GlaxoSmithKline BV. (Netherlands)</td><td>100</td><td>Glaxo Wellcome Manufacturing Pte Ltd (Singapore)</td><td>100</td></tr><tr><td>GlaxoSmithKline Biologicals SA (Belgium)</td><td>100</td><td>GlaxoSmithKline (Thailand) Limited (Thailand)</td><td>100</td></tr><tr><td>GlaxoSmithKline GmbH &amp; Co. KG (Germany)</td><td>100</td><td>GlaxoSmithKline Australia Pty Ltd (Australia)</td><td>100</td></tr><tr><td>GlaxoSmithKline Pharma GmbH (Austria)</td><td>100</td><td>GlaxoSmithKline Brasil Limitada (Brazil)</td><td>100</td></tr><tr><td>GlaxoSmithKline Pharmaceuticals SA (Belgium)</td><td>100</td><td>GlaxoSmithKline Far East B.V. (Taiwan)</td><td>100</td></tr><tr><td>GlaxoSmithKline S.A. (Spain)</td><td>100</td><td>GlaxoSmithKline Iaclarli Sanayi ve Ticaret A.S. (Turkey)</td><td>100</td></tr><tr><td>GlaxoSmithKline S.p.A. (Italy)</td><td>100</td><td>GlaxoSmithKline Inc. (Canada)</td><td>100</td></tr><tr><td>GlaxoSmithKline Single Member A.E.B.E. (Greece)</td><td>100</td><td>GlaxoSmithKline K.K. (Japan)</td><td>100</td></tr><tr><td>GlaxoSmithKline Trading Services Limited (Republic of Ireland) \( ^{9} \)</td><td>100</td><td>GlaxoSmithKline Korea Limited (Republic of Korea)</td><td>100</td></tr><tr><td>GSK Capital BV. (Netherlands) \( ^{9} \)</td><td>100</td><td>GlaxoSmithKline Limited (Hong Kong)</td><td>100</td></tr><tr><td>GSK Services Sp z o.o. (Poland)</td><td>100</td><td>GlaxoSmithKline Mexico S.A. de C.V. (Mexico)</td><td>100</td></tr><tr><td>GSK Vaccines GmbH (Germany)</td><td>100</td><td>GlaxoSmithKline Pakistan Limited (Pakistan)</td><td>82.6</td></tr><tr><td>GSK Vaccines Srl. (Italy)</td><td>100</td><td>GlaxoSmithKline Pharmaceuticals Limited (India)</td><td>75</td></tr><tr><td>JSC GlaxoSmithKline Trading (Russia)</td><td>100</td><td>GSK Enterprise Management Co, Ltd (China)</td><td>100</td></tr><tr><td>Laboratoire GlaxoSmithKline (France)</td><td>100</td><td>GSK Pharma Vietnam Company Limited (Vietnam)</td><td>100</td></tr><tr><td>Laboratories ViIV Healthcare, S.L. (Spain)</td><td>78.3</td><td>ID Biomedical Corporation of Quebec (Canada)</td><td>100</td></tr><tr><td>ViIV Healthcare GmbH (Germany)</td><td>78.3</td><td>ViIV Healthcare K.K (Japan)</td><td>78.3</td></tr><tr><td>ViIV Healthcare Srl. (Italy)</td><td>78.3</td><td>ViIV Healthcare ULC (Canada)</td><td>78.3</td></tr><tr><td>ViIV Healthcare SAS (France)</td><td>78.3</td><td></td><td></td></tr></table>

(a) Directly held wholly-owned subsidiary of GSK plc.

(b) Tax resident in UK.

(c) GSK GP 1 Limited is a subsidiary undertaking of GSK plc and Berkeley Square Pension Trustee Company Limited and is the general partner of GSK (No.1) Scottish Limited Partnership and GSK (No.2) Scottish Limited Partnership. GSK GP 1 Limited's share capital is 99% indirectly owned by GSK plc and 1% owned by Berkeley Square Pension Trustee Company Limited.

(d) GSK GP 2 Limited is a subsidiary undertaking of GSK plc and is the general partner of GSK (No.3) Scottish Limited Partnership. GSK GP 2 Limited's share capital is 100% indirectly owned by GSK plc.

The subsidiaries and associates listed above principally affect the figures in the Group's financial statements. Each of GlaxoSmithKline Capital Inc., GlaxoSmithKline Capital plc, GlaxoSmithKline Finance plc, GSK Capital BV and GlaxoSmithKline LLC, is a wholly-owned finance subsidiary of the company, and the company has fully and unconditionally guaranteed the securities issued by each of GlaxoSmithKline Capital Inc., GlaxoSmithKline Capital plc, GlaxoSmithKline Finance plc, GSK Capital BV and GlaxoSmithKline LLC.

See pages 307 to 314 for a complete list of subsidiary undertakings, associates and joint ventures, which form part of these financial statements.



## 47. Legal proceedings

The Group is involved in significant legal and administrative proceedings, principally product liability, intellectual property, tax, anti-trust, consumer fraud and governmental investigations. The most significant of these matters, other than tax matters, are described below. The Group makes provision for these proceedings on a regular basis as summarised in Note 2, 'Accounting principles and policies' and Note 32, 'Other provisions'. Note 2 also describes when disclosure is made of proceedings for which there is no provision. Legal expenses incurred and provisions related to legal claims are charged to selling, general and administration costs. The Group does not believe that information about the amount sought by plaintiffs, if that is known, would be meaningful with respect to those legal proceedings. This is due to a number of factors, including, but not limited to, the stage of proceedings, the entitlement of parties to appeal a decision and clarity as to theories of liability, damages and governing law.

At 31 December 2022, the Group’s aggregate provision for legal and other disputes (not including tax matters described in Note 14, ‘Taxation’) was £218 million. There can be no assurance that any losses that result from the outcome of any legal proceedings will not exceed by a material amount the amount of the provisions reported in the Group’s financial statements. If this were to happen, it could have a material adverse impact on the results of operations of the Group in the reporting period in which the judgements are incurred or the settlements entered into.

## Intellectual property

Intellectual property claims include challenges to the validity and enforceability of the Group’s patents on various products or processes as well as assertions of non-infringement of those patents. A loss in any of these cases could result in loss of patent protection for the product at issue. The consequences of any such loss could be a significant decrease in sales of that product and could materially affect future results of operations for the Group.

## Coreg

In 2014, GSK initiated suit against Teva for inducing infringement of its patent relating to the use of carvedilol (Coreg) in decreasing mortality caused by congestive heart failure. In June 2017, the case proceeded to a jury trial in the US District Court for the District of Delaware. The jury returned a verdict in GSK’s favour, awarding GSK lost profits and reasonable royalties for a total award of $235.51 million. On 29 March 2018, the trial judge ruled on post-trial motions filed by Teva and found that substantial evidence at trial did not support the jury’s finding of induced infringement, overturning the jury award. GSK appealed, and on 2 October 2020, a divided panel of the Court of Appeals for the Federal Circuit reversed the district court’s ruling and reinstated the jury award in GSK’s favour.
On 2 December 2020, Teva filed a petition for rehearing en banc. The court granted Teva’s petition, but only for a rehearing by the three-member panel that issued the original decision. On 5 August 2021, the original panel issued its rehearing opinion where the majority again reinstated the jury’s damages award of $235.51 million in GSK’s favour.

Teva again filed a petition for rehearing en banc which was rejected by the Court of Appeals for the Federal Circuit on 11 February 2022. On 11 July 2022, Teva filed a petition for writ of certiorari with the Supreme Court of the United States seeking to overturn the Federal Court decision. On 3 October 2022, the Supreme Court invited the United States Solicitor General to file briefs expressing the views of the United States.

## Dolutegravir Proceedings

## – Tivicay/Triumeq

In September 2021, ViiV Healthcare received a paragraph IV letter from Lupin relating to the Tivicay 5mg dosage for oral suspension, challenging only the crystal form patent. On 2 November 2021, ViiV Healthcare filed suit against Lupin in the US District Court for the District of Delaware. No trial date has yet been set.

## – Dovato

In September 2019, ViiV Healthcare received a paragraph IV letter from Cipla relating to Dovato and challenging only the crystal form patent. On 4 November 2019, ViiV Healthcare filed suit against Cipla in the US District Court for the District of Delaware. A settlement has been reached in the case.

## – Juluca

In January 2020, ViiV Healthcare received a paragraph IV letter from Lupin relating to Juluca and challenging the crystal form patent as well as a patent relating to the combination of dolutegravir and rilpivirine that expires on 24 January 2031. On 28 February 2020, ViiV Healthcare filed suit against Lupin on both patents. A settlement has been reached with Lupin. Additionally, on 12 June 2020, Cipla sent ViiV Healthcare a paragraph IV letter related to Juluca, and on 22 July 2020, ViiV Healthcare filed suit against Cipla in federal court in Delaware. The court has not set a trial date.

## Product liability

The Group is currently a defendant in a number of product liability lawsuits.

## Avandia

There are two pending US class actions brought by third-party payers which assert claims under the Racketeer Influenced and Corrupt Organizations Act (RICO) and state consumer protection laws. In December 2019, the Third Circuit Court of Appeals reversed the summary judgements granted in favour of the Group and remanded the third-party payer cases back to district court. Discovery is underway in the district court but no trial dates have yet been set. It is possible that a class certification hearing will be held in 2023.



## Notes to the financial statements continued

## 47. Legal proceedings continued

## Zantac

In 2019, the Group was contacted by several regulatory authorities regarding the detection of N-Nitroso-dimethylamine (NDMA) in Zantac (ranitidine) products. Based on information available at the time and correspondence with regulators, the Group made the decision to suspend the release, distribution and supply of all dose forms of Zantac to all markets pending the outcome of the ongoing tests and investigations. Also, as a precautionary action, the Group made the decision to initiate a voluntary pharmacy/retail level recall of Zantac products globally.

On 30 April 2020, the European Medicines Agency (EMA) recommended the suspension of ranitidine medicines. Following the publication of the EMA’s recommendation, the Company communicated a decision not to re-enter the market. In the US, FDA requested that all manufacturers withdraw ranitidine products from the market.

The Group has been named as a defendant in approximately 4,500 personal injury cases in US state courts and the federal Zantac Multidistrict Litigation (MDL) court proceeding in the Southern District of Florida. There are approximately 84,000 plaintiffs named in these cases. A significant majority of these plaintiffs were named in a series of multi-plaintiff complaints filed in Delaware state court and most of these plaintiffs were previously in the MDL Census Registry. They were removed because they allege a cancer other than the 5 cancers being pursued by the MDL plaintiffs. In the MDL, plaintiffs originally identified 10 different types of cancers they wished to pursue. Plaintiffs subsequently dropped 5 of the 10 cancers, and proceeded only as to bladder, esophageal, gastric, liver, and pancreatic cancers, although plaintiffs in state courts continue to pursue claims beyond the 5 designated cancers. There are 46,697 unfiled claims relating to the Group and other co-defendants (32,970 mapped to the Group) concerning the 5 designated cancers in the MDL Census Registry. There are also over 2,000 California state court cases subject to an agreement between the Group and the plaintiffs which suspends the statute of limitations to allow the plaintiffs to bring their claims at a later date. These filed and unfiled counts are subject to change.

On 6 December 2022, the court presiding over the federal MDL proceeding granted Defendants' Daubert motions, finding that Plaintiffs' experts' causation opinions regarding whether Zantac can cause the five cancers at issue in the MDL (liver, bladder, pancreatic, esophageal, and stomach) are unreliable and thus inadmissible. Without expert causation opinions, the MDL Court granted summary judgment to GSK and the other brand defendants. The MDL Court found that "there is no scientist outside this litigation who concluded ranitidine causes cancer, and the plaintiffs' scientists within this litigation systemically utilized unreliable methodologies," and failed to use "consistent, objective, science-based standards for the even-handed evaluation of data." This ruling effectively dismissed approximately 2,200 filed cases in the MDL and is binding on all of the claims in the Census Registry. Plaintiffs have indicated they will appeal the MDL decision.
In the California Zantac litigation Cases JCCP 5150 (JCCP), the Court held a Sargon hearing regarding the admissibility of expert witness testimony, including the testimony of general and specific causation expert witnesses, for the first bellwether trial. The hearing occurred over a four-day period in February and March 2023. The first bellwether trial, which is a bladder cancer case, was expected to start on 27 February 2023 in the California JCCP, however the Court has moved the trial date to 24 July 2023. Three other California bellwether trials have been scheduled for May, August and October 2023, although these dates are likely to be extended as well.

The Illinois Supreme Court recently consolidated all Illinois ranitidine cases in Cook County for pretrial proceedings with trial dates to be set at a later date, including the previously scheduled Madison County trial.

Beyond the personal injury actions, class actions alleging economic injury and a third-party payer class action also have been filed in federal court. Plaintiffs have moved to stay the class actions pending appeal of the Daubert ruling. Defendants oppose the request for stay and are asking the Court to dismiss the class actions. Outside the US, there are seven class actions pending against the Group in Canada, along with a class action in Israel.

Given the complex ownership and marketing of Zantac prescription and over-the-counter (OTC) medicine over many years, numerous claims involve several defendants. As a result, some defendants have served one another, including the Group, with notice of potential indemnification claims about possible liabilities connected particularly with Zantac OTC. Given the early stage of the proceedings, the Group cannot meaningfully assess what liability, if any, it may have, nor can it meaningfully assess the liability of other parties under relevant indemnification provisions.

In addition, on 20 March 2020, the Department of Justice (DOJ) sent the Group notice of a civil investigation it had opened into allegations of False Claims Act violations by the Group related to Zantac. On 18 June 2020, the DOJ served a Civil Investigative Demand on the Group, formalizing its request for documents. On the same day, the New Mexico Attorney General filed a lawsuit against multiple defendants, including the Group, alleging violations of state consumer protection and false advertising statutes, among other claims.

## Zofran

The Group was a defendant in over 400 product liability cases involving Zofran pending in a Multidistrict Litigation (MDL) proceeding in the District of Massachusetts. The cases alleged that children suffered birth defects due to their mothers' ingestion of Zofran and/or generic ondansetron for pregnancy-related nausea and vomiting. Plaintiffs asserted that the Group sold Zofran knowing it was unsafe for pregnant women, failed to warn of the risks and illegally marketed Zofran "off-label" for use by pregnant women.



## Notes to the financial statements continued

## 47. Legal proceedings continued

On 1 June 2021, the MDL Court granted the Group’s motion for summary judgment on federal pre-emption grounds. The Court found that the FDA was fully informed of all relevant safety information regarding Zofran and had repeatedly rejected any attempt to add a birth defect warning to the label. At that time, the Court granted judgment for the Group in all cases pending in the MDL (approximately 431 cases) and closed the MDL proceeding. Plaintiffs appealed this decision and, on 9 January 2023, the United States Court of Appeals for the First Circuit affirmed the district court’s decision in favour of the Group.

There remains one state court case and four proposed class actions in Canada.

## Sales and marketing and regulation

The Group’s marketing and promotion of its Pharmaceutical and Vaccine products are the subject of certain governmental investigations and private lawsuits brought by litigants under various theories of law.

## GSK Korea – Proceedings under Fair Trade Laws

In August 2020, GSK Korea was indicted under Korea’s Monopoly Regulation and Fair Trade laws in relation to government tenders of HPV (Cervarix) and PCV (Synflorix) vaccines in 2018 and 2019. The prosecutor alleged that GSK Korea, through the actions of at least one of its employees, interfered with the tender process under the National Immunisation Programme by using “straw bidders.”

A former GSK Korea employee was also charged in his individual capacity by the prosecutor in relation to the same matter. Further, a number of wholesalers are co-defendants in the proceedings. On 1 February 2023, the court rendered a guilty verdict in respect of all defendants. GSK Korea was fined KRW 70 million which is approximately £45,000. Appeal proceedings are ongoing.

The Korea Fair Trade Commission also has commenced proceedings regarding the same matter. GSK Korea is cooperating with the authorities on these matters.

## Anti-trust/competition

Certain governmental actions and private lawsuits have been brought against the Group alleging violation of competition or anti-trust laws.

## Lamictal

Purported classes of direct purchasers filed suit in the US District Court for the District of New Jersey alleging that the Group and Teva Pharmaceuticals unlawfully conspired to delay generic competition for Lamictal, resulting in overcharges to the purchasers, by entering into an allegedly anti-competitive reverse payment settlement to resolve patent infringement litigation. A separate count accuses the Group of monopolising the market.

On 13 December 2018, the trial judge granted plaintiffs' class certification motion, certifying a class of direct purchasers. The Group filed a Rule 23(f) motion in the Court of Appeals for the Third Circuit, challenging the class certification decision. On 22 April 2020, the Court of Appeals vacated the lower court's grant of class certification and remanded the issue back to the lower court for further analysis.

On 9 October 2020, the district court heard argument on plaintiffs' renewed motion for class certification after remand. On 9 April 2021, the district court denied Plaintiffs' motion for class certification of the putative direct purchaser class, leaving a potential class of brand-only purchasers. Plaintiffs moved to supplement their expert report and seek additional discovery to support the addition of certain generic purchasers. On 21 January 2022, the district court denied Plaintiffs' motion to supplement their expert report and seek additional discovery and held that the issue of generic purchasers had already been decided and denied in the court's ruling on decertification. The parties have conducted briefing on class certification as to the remaining brand-only purchasers, with plaintiffs also seeking to add a smaller category of purchasers.

On 1 February 2023, the district court denied Plaintiffs' renewed class certification motion. A follow-on complaint was filed in the US District Court for the Eastern District of Pennsylvania on 2 February 2023 by a group of alleged purchasers.

## Commercial and corporate

The Group is involved in certain contractual and/or commercial disputes.

## Zejula Royalty Dispute

In October 2012, Tesaro, Inc. (now a wholly owned subsidiary of GSK) entered into two worldwide patent license agreements with AstraZeneca UK Limited related to niraparib (later approved as Zejula). In May 2021, AstraZeneca filed a lawsuit against Tesaro in the High Court, England and Wales alleging that Tesaro failed to pay some of the royalties due under the license agreements. Tesaro has counterclaimed based on a calculated overpayment. A trial is scheduled for March 2023

## 48. Post balance sheet events

There is no material post balance sheet event that requires an adjustment or a disclosure within the financial statements.



## Company balance sheet – UK GAAP

(including FRS 101 ‘Reduced Disclosure Framework’) as at 31 December 2022

<table><tr><td></td><td>Notes</td><td>2022
£m</td><td>2022
£m</td><td>2021
£m</td><td>2021
£m</td></tr><tr><td>Fixed assets - investments</td><td>E</td><td></td><td>22,881</td><td></td><td>54,995</td></tr><tr><td>Current assets:</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Trade and other receivables</td><td>F</td><td></td><td>17,748</td><td></td><td>2,720</td></tr><tr><td>Cash at bank</td><td></td><td></td><td>20</td><td></td><td>17</td></tr><tr><td>Total current assets</td><td></td><td></td><td>17,768</td><td></td><td>2,737</td></tr><tr><td>Trade and other payables</td><td>G</td><td></td><td>(545)</td><td></td><td>(598)</td></tr><tr><td>Total current liabilities</td><td></td><td></td><td>(545)</td><td></td><td>(598)</td></tr><tr><td>Net current assets</td><td></td><td></td><td>17,223</td><td></td><td>2,139</td></tr><tr><td>Total assets less current liabilities</td><td></td><td></td><td>40,104</td><td></td><td>57,134</td></tr><tr><td>Provisions for liabilities</td><td>H</td><td></td><td>(13)</td><td></td><td>(12)</td></tr><tr><td>Other non-current liabilities</td><td>I</td><td></td><td>(645)</td><td></td><td>(458)</td></tr><tr><td>Net assets</td><td></td><td></td><td>39,446</td><td></td><td>56,664</td></tr><tr><td>Capital and reserves</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Share capital</td><td>J</td><td></td><td>1,347</td><td></td><td>1,347</td></tr><tr><td>Share premium account</td><td>J</td><td></td><td>3,440</td><td></td><td>3,301</td></tr><tr><td>Other reserves</td><td>K</td><td></td><td>1,420</td><td></td><td>1,420</td></tr><tr><td>Retained earnings:</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>At 1 January</td><td></td><td>50,596</td><td></td><td>49,653</td><td></td></tr><tr><td>Profit/(loss) for the year</td><td></td><td>710</td><td></td><td>4,942</td><td></td></tr><tr><td>Treasury shares transferred to the ESOP Trust</td><td></td><td>1,089</td><td></td><td>-</td><td></td></tr><tr><td>Dividends in specie</td><td></td><td>(15,689)</td><td></td><td>-</td><td></td></tr><tr><td>Dividends paid to shareholders</td><td></td><td>(3,467)</td><td></td><td>(3,999)</td><td></td></tr><tr><td></td><td>K</td><td></td><td>33,239</td><td></td><td>50,596</td></tr><tr><td>Equity shareholders&#x27; funds</td><td></td><td></td><td>39,446</td><td></td><td>56,664</td></tr></table>

The financial statements on pages 268 to 272 were approved by the Board on 9 March 2023 and signed on its behalf by

Sir Jonathan Symonds

Chair
GSK plc
Registered number: 3888792

## Company statement of changes in equity for the year ended 31 December 2022

<table><tr><td></td><td>Share capital £m</td><td>Share premium account £m</td><td>Other reserves £m</td><td>Retained earnings £m</td><td>Total equity £m</td></tr><tr><td>At 1 January 2021</td><td>1,346</td><td>3,281</td><td>1,420</td><td>49,653</td><td>55,700</td></tr><tr><td>Profit and Total comprehensive income attributable to shareholders</td><td>-</td><td>-</td><td>-</td><td>4,942</td><td>4,942</td></tr><tr><td>Dividends to shareholders</td><td>-</td><td>-</td><td>-</td><td>(3,999)</td><td>(3,999)</td></tr><tr><td>Shares issued under employee share schemes</td><td>1</td><td>20</td><td>-</td><td>-</td><td>21</td></tr><tr><td>At 31 December 2021</td><td>1,347</td><td>3,301</td><td>1,420</td><td>50,596</td><td>56,664</td></tr><tr><td>Profit and Total comprehensive income attributable to shareholders</td><td>-</td><td>-</td><td>-</td><td>710</td><td>710</td></tr><tr><td>Treasury shares transferred to the ESOP Trust</td><td></td><td></td><td></td><td>1,089</td><td>1,089</td></tr><tr><td>Dividends to shareholders (Note D)</td><td>-</td><td>-</td><td>-</td><td>(3,467)</td><td>(3,467)</td></tr><tr><td>Dividends in specie (Note D)</td><td>-</td><td>-</td><td>-</td><td>(15,689)</td><td>(15,689)</td></tr><tr><td>Shares issued under employee share schemes</td><td>-</td><td>139</td><td>-</td><td>-</td><td>139</td></tr><tr><td>At 31 December 2022</td><td>1,347</td><td>3,440</td><td>1,420</td><td>33,239</td><td>39,446</td></tr></table>



# Notes to the company balance sheet – UK GAAP (including FRS 101 ‘Reduced Disclosure Framework’)

## A) Presentation of the financial statements

## Description of business

GSK plc is the parent company of GSK, a major global biopharma group which makes innovative vaccines and specially medicines to prevent and treat disease. GSK’s R&D focuses on the science of the immune system, human genetics and advanced technologies primarily in the following four therapeutic areas: infectious diseases, HIV, oncology and immunology/respiratory.

## Preparation of financial statements

The financial statements, which are prepared using the historical cost convention (as modified to include the revaluation of certain financial instruments) and on a going concern basis, are prepared in accordance with Financial Reporting Standard 101 'Reduced Disclosure Framework' and with UK accounting presentation and the Companies Act 2006 as at 31 December 2022, with comparative figures as at 31 December 2021.

As permitted by section 408 of the Companies Act 2006, the income statement of the company is not presented in this Annual Report.

The company is included in the Group financial statements of GSK plc, which are publicly available.

The following exemptions from the requirements of IFRS have been applied in the preparation of these financial statements, in accordance with FRS 101:

– Paragraphs 45(b) and 46 to 52 of IFRS 2, ‘Share-based payment’

– IFRS 7, ‘Financial Instruments – Disclosures’

– Paragraphs 91-99 of IFRS 13, ‘Fair value measurement’

– Paragraph 38 of IAS 1, ‘Presentation of financial statements’ comparative information requirements in respect of paragraph 79(a) (iv) of IAS 1

– Paragraphs 10(d), 10(f), 16, 38(A), 38 (B to D), 40 (A to D), 111 and 134 to 136 of IAS 1, ‘Presentation of financial statements’

– IAS 7, ‘Statement of cash flows’

– Paragraph 30 and 31 of IAS 8, ‘Accounting policies, changes in accounting estimates and errors’

– Paragraph 17 of IAS 24, ‘Related party disclosures’ and the further requirement in IAS 24 to disclose related party transactions entered into between two or more members of a Group.

## Accounting convention and standards

The balance sheet has been prepared using the historical cost convention and complies with applicable UK accounting standards.

## Accounting principles and policies

The preparation of the balance sheet in conformity with generally accepted accounting principles requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the balance sheet. Actual amounts could differ from those estimates. The balance sheet has been prepared in accordance with the company’s accounting policies approved by the Board and described in Note B. These policies have been consistently applied, unless otherwise stated.

## Key accounting judgements and estimates

No key accounting judgements or estimates were required in the current year.

## B) Accounting policies

## Foreign currency transactions

Foreign currency transactions are recorded at the exchange rate ruling on the date of transaction. Foreign currency assets and liabilities are translated at rates of exchange ruling at the balance sheet date.

## Dividends paid and received

Dividends paid and received are included in the financial statements in the period in which the related dividends are actually paid or received.

## Expenditure

Expenditure is recognised in respect of goods and services received when supplied in accordance with contractual terms. Provision is made when an obligation exists for a future liability in respect of a past event and where the amount of the obligation can be reliably estimated.

## Investments in subsidiary companies

Investments in subsidiary companies are held at cost less any provision for impairment and also includes a capital contribution in relation to movements in contingent consideration.

## Impairment of investments

The carrying value of investments are reviewed for impairment when there is an indication that the investment might be impaired. One of the assessment methods used is to compare the carrying value of each investment against its share of the net assets value of the investment or against its share of the valuation of the subsidiary based on expected discounted cash flows. The total amount of investments is also evaluated against the Group’s valuation on the basis of overall market capitalisation. Any impairment charge is recognised in the income statement in the year concerned.

## Assets held for sale/distribution

Non-current assets are held for disposal/demerger only if available for immediate disposal/demerger in their present condition, a disposal/demerger is highly probable and expected to be completed within one year from the date of classification. Such assets are measured at the lower of carrying value and fair value less the cost of disposal.

## Share-based payments

The issuance by the company to its subsidiaries of a grant over the company’s shares, represents additional capital contributions by the company in its subsidiaries. An additional investment in subsidiaries results in a corresponding increase in shareholders’ equity. The additional capital contribution is based on the fair value of the grant issued, allocated over the underlying grant’s vesting period.



## Notes to the company balance sheet – UK GAAP (including FRS 101 ‘Reduced Disclosure Framework’) continued

## Taxation

Current tax is provided at the amounts expected to be paid applying tax rates that have been enacted or substantively enacted by the balance sheet date.

Deferred tax is provided in full, using the liability method, on temporary differences arising between the tax bases of assets and liabilities and their carrying amounts in the financial statements. Deferred tax assets are only recognised to the extent that they are considered recoverable against future taxable profits.

Deferred tax is measured at the average tax rates that are expected to apply in the periods in which the temporary differences are expected to be realised or settled. Deferred tax liabilities and assets are not discounted.

## D) Dividends

The Directors declared four interim dividends resulting in a dividend for the year of 61.25 pence adjusted for the share consolidation. For further details, see Note 16 to the Group financial statements, 'Dividends'.

In addition, the demerger of the Consumer Healthcare business was implemented by GSK declaring an interim dividend as follows.

<table><tr><td></td><td>£m</td></tr><tr><td>Dividend in specie of Haleon plc shares distributed to external shareholders</td><td>15,526</td></tr><tr><td>Dividend in specie of Haleon plc shares distributed to the ESOP Trusts</td><td>163</td></tr><tr><td></td><td>15,689</td></tr></table>

## E) Fixed assets – investments

<table><tr><td></td><td>2022</td><td>2021</td></tr><tr><td></td><td>£m</td><td>£m</td></tr><tr><td>Shares in GlaxoSmithKline Services Unlimited</td><td>637</td><td>637</td></tr><tr><td>Shares in GlaxoSmithKline Holdings (One) Limited</td><td>18</td><td>18</td></tr><tr><td>Shares in GlaxoSmithKline Holdings Limited</td><td>17,888</td><td>17,888</td></tr><tr><td>Shares in GlaxoSmithKline Consumer Healthcare Holdings Limited</td><td>-</td><td>34,800</td></tr><tr><td>Shares in GlaxoSmithKline Mercury Limited</td><td>33</td><td>33</td></tr><tr><td>Shares in GSK LP Limited</td><td>2,493</td><td>-</td></tr><tr><td></td><td>21,069</td><td>53,376</td></tr><tr><td>Capital contribution relating to share-based payments</td><td>1,139</td><td>1,139</td></tr><tr><td>Contribution relating to contingent consideration</td><td>673</td><td>480</td></tr><tr><td></td><td>22,881</td><td>54,995</td></tr></table>

The investments in GlaxoSmithKline Consumer Healthcare Holdings Limited were derecognised of as part of the demerger of the Consumer Healthcare business, which was executed in specie shares (see Note 41 to the Group financial statements).

## F) Trade and other receivables

<table><tr><td></td><td>2022</td><td>2021</td></tr><tr><td></td><td>£m</td><td>£m</td></tr><tr><td>Amounts due within one year:</td><td></td><td></td></tr><tr><td>UK Corporation tax recoverable</td><td>-</td><td>9</td></tr><tr><td>Other debtors</td><td>2</td><td>-</td></tr><tr><td>Amounts owed by Group undertakings</td><td>17,422</td><td>2,319</td></tr><tr><td></td><td>17,424</td><td>2,328</td></tr><tr><td>Amounts due after more than one year:</td><td></td><td></td></tr><tr><td>Amounts owed by Group undertakings</td><td>324</td><td>392</td></tr><tr><td></td><td>17,748</td><td>2,720</td></tr></table>

The movement in the Amounts owed by Group undertakings in the period, as reflected within Notes F and G, primarily reflects the receipt of dividend income from subsidiaries including the pre-demerger dividend from GlaxoSmithKline Consumer Healthcare Holdings Limited and utilisation of the company’s current account to fund the payment of interim dividends.



## Notes to the company balance sheet – UK GAAP (including FRS 101 ‘Reduced Disclosure Framework’) continued

## G) Trade and other payables

<table><tr><td></td><td>2022
£m</td><td>2021
£m</td></tr><tr><td>Amounts due within one year:</td><td></td><td></td></tr><tr><td>Other creditors</td><td>396</td><td>457</td></tr><tr><td>Contingent consideration payable</td><td>28</td><td>22</td></tr><tr><td>Corporation tax</td><td>18</td><td>-</td></tr><tr><td>Amounts owed to Group undertakings</td><td>103</td><td>119</td></tr><tr><td></td><td>545</td><td>598</td></tr></table>

The company has guaranteed debt issued by its subsidiary companies from one of which it receives fees. In aggregate, the company has outstanding guarantees over £19.5 billion of debt instruments (2021: £22.4 billion). The amounts due from the subsidiary company in relation to these guarantee fees will be recovered over the life of the bonds and are disclosed within 'Trade and other receivables' (see Note 26).

## H) Provisions for liabilities

<table><tr><td></td><td>2022</td><td>2021</td></tr><tr><td>At 1 January</td><td>12</td><td>7</td></tr><tr><td>Charge for the year</td><td>43</td><td>24</td></tr><tr><td>Utilised</td><td>(42)</td><td>(19)</td></tr><tr><td>At 31 December</td><td>13</td><td>12</td></tr></table>

The provisions relate to a number of legal and other disputes in which the company is currently involved.

## I) Other non-current liabilities

<table><tr><td></td><td>2022</td><td>2021</td></tr><tr><td>Contingent consideration payable</td><td>645</td><td>458</td></tr></table>

The contingent consideration relates to the amount payable for the acquisition in 2015 of the Novartis Vaccines portfolio. The current year liability is included within 'Trade and other payables'. For further details, see Note 33 to the Group financial statements, 'Contingent consideration liabilities'.

## J) Share capital and share premium account

<table><tr><td rowspan="2"></td><td colspan="2">Ordinary shares</td><td rowspan="2">Share premium account</td></tr><tr><td>Number</td><td>£m</td></tr><tr><td>Share capital issued and fully paid</td><td></td><td></td><td></td></tr><tr><td>At 1 January 2021</td><td>5,385,189,617</td><td>1,346</td><td>3,281</td></tr><tr><td>Issued under employee share schemes</td><td>1,825,442</td><td>1</td><td>20</td></tr><tr><td>At 31 December 2021</td><td>5,387,015,059</td><td>1,347</td><td>3,301</td></tr><tr><td>Impact of share consolidation</td><td>(1,077,403,011)</td><td>-</td><td>-</td></tr><tr><td>Issued under employee share schemes</td><td>1,731,293</td><td>-</td><td>25</td></tr><tr><td>Ordinary shares acquired by ESOP Trust</td><td>-</td><td>-</td><td>114</td></tr><tr><td>At 31 December 2022</td><td>4,311,343,341</td><td>1,347</td><td>3,440</td></tr></table>

At 31 December 2022, of the issued share capital, 59,878,735 shares were held in the ESOP Trusts, 217,124,760 shares were held as Treasury shares and 4,034,339,846 shares were in free issue. All issued shares are fully paid and there are no shares authorised but not in issue. The nominal, carrying and market values of the shares held in the ESOP Trusts are disclosed in Note 45, 'Employee share schemes'.



## Notes to the company balance sheet – UK GAAP (including FRS 101 ‘Reduced Disclosure Framework’) continued

## K) Retained earnings and other reserves

The profit of GSK plc for the year was £710 million (2021: £4,942 million profit). After dividends paid and distributed in specie of £19,156 million (including the Consumer Healthcare business demerger dividend of £15,689 million) (2021: £3,999 million), and the effect of £1,089 million Treasury shares transferred to a subsidiary company (2021: £nil) retained earnings at 31 December 2022 stood at £33,239 million (2021: £50,596 million), of which £8,140 million was unrealised (2021: £38,896 million). Dividends to shareholders are paid out of the realised profits of the company, which at 31 December 2022 amounted to £25,099 million (2021: £11,700 million).

Other reserves includes a capital redemption reserve and a reserve reflecting historical contributions of shares in the company which were issued to satisfy share option awards granted to employees of subsidiary companies.

## L) Divestment

On 18 July 2022, GSK plc separated its Consumer Healthcare business from the GSK Group to form Haleon plc, an independent listed company. The separation was effected by way of a demerger of 80.1% of GSK's 68% holding in the Consumer Healthcare business to GSK shareholders. Following the demerger, 54.47% of Haleon plc is held in aggregate by GSK Shareholders, 6.03% is held by GSK (including shares received by GSK's consolidated ESOT trusts) and 7.5% is held by three Scottish Limited Partnerships (SLPs) set up to provide collateral for a funding mechanism pursuant to which GSK will provide additional funding for GSK's UK Pension Schemes. The aggregate ownership by GSK (including ownership by the ESOT trust and SLPs) after the demerger is 13.53%.

Following completion of the Consumer Healthcare business demerger, on 18 July 2022, GSK plc Ordinary shares were consolidated in order to maintain share price comparability before and after demerger. The consolidation was approved by GSK plc shareholders at a General Meeting held on 6 July 2022. Shareholders of GSK plc received 4 new Ordinary shares with a nominal value of 31.25 pence each for each existing 5 Ordinary share which had a nominal value of 25 pence each.

## M) Group companies

See pages 307 to 314 for a complete list of subsidiaries, associates, joint ventures and other significant shareholdings, which forms part of these financial statements.



## Investor
information

<table><tr><td colspan="2">In this section</td></tr><tr><td>Commercial Operations turnover</td><td>274</td></tr><tr><td>Three year record</td><td>276</td></tr><tr><td>Product development pipeline</td><td>278</td></tr><tr><td>Products, competition and intellectual property</td><td>282</td></tr><tr><td>Principal risks and uncertainties</td><td>285</td></tr><tr><td>Share capital and control</td><td>296</td></tr><tr><td>Dividends</td><td>298</td></tr><tr><td>Financial calendar 2023</td><td>299</td></tr><tr><td>Annual General Meeting 2023</td><td>299</td></tr><tr><td>Tax information for shareholders</td><td>299</td></tr><tr><td>Shareholder services and contacts</td><td>302</td></tr><tr><td>US law and regulation</td><td>304</td></tr><tr><td>Group companies</td><td>307</td></tr><tr><td>Glossary of terms</td><td>315</td></tr></table>



## Financial record

Commercial Operations turnover by therapeutic area 2022

<table><tr><td rowspan="3"></td><td colspan="4">Total</td><td colspan="2">US</td><td colspan="4">Europe</td><td colspan="2">International</td></tr><tr><td colspan="2">2022</td><td colspan="2">Growth</td><td colspan="2">2022</td><td colspan="2">Growth</td><td colspan="2" rowspan="2">2022</td><td colspan="2">Growth</td></tr><tr><td>€m</td><td>€%</td><td>CER%</td><td>€m</td><td>€%</td><td>CER%</td><td>€m</td><td>€%</td><td>C</td><td>ER%</td></tr><tr><td>HIV</td><td>5,749</td><td>20</td><td>12</td><td>3,756</td><td>30</td><td>17</td><td>1,310</td><td>10</td><td>10</td><td>683</td><td>-</td><td>(3)</td></tr><tr><td>Dolutegravir products</td><td>5,191</td><td>14</td><td>6</td><td>3,311</td><td>19</td><td>8</td><td>1,239</td><td>8</td><td>8</td><td>641</td><td>-</td><td>(3)</td></tr><tr><td>Tivicay</td><td>1,381</td><td>-</td><td>(7)</td><td>823</td><td>8</td><td>(3)</td><td>273</td><td>(5)</td><td>(4)</td><td>285</td><td>(14)</td><td>(19)</td></tr><tr><td>Trumeq</td><td>1,799</td><td>(4)</td><td>(11)</td><td>1,217</td><td>2</td><td>(8)</td><td>361</td><td>(20)</td><td>(19)</td><td>221</td><td>(8)</td><td>(9)</td></tr><tr><td>Juluca</td><td>636</td><td>23</td><td>14</td><td>494</td><td>26</td><td>13</td><td>127</td><td>14</td><td>15</td><td>15</td><td>15</td><td>8</td></tr><tr><td>Dovato</td><td>1,375</td><td>75</td><td>65</td><td>777</td><td>82</td><td>64</td><td>478</td><td>58</td><td>59</td><td>120</td><td>&gt;100</td><td>&gt;100</td></tr><tr><td>Rukobia</td><td>82</td><td>82</td><td>64</td><td>79</td><td>84</td><td>65</td><td>3</td><td>50</td><td>50</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Cabenuva</td><td>340</td><td>&gt;100</td><td>&gt;100</td><td>294</td><td>&gt;100</td><td>&gt;100</td><td>40</td><td>&gt;100</td><td>&gt;100</td><td>6</td><td>&gt;100</td><td>&gt;100</td></tr><tr><td>Apretude</td><td>41</td><td>-</td><td>-</td><td>41</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>&lt;nl&gt;</td></tr><tr><td>Others</td><td>95</td><td>(25)</td><td>(29)</td><td>31</td><td>(37)</td><td>(45)</td><td>28</td><td>(22)</td><td>(22)</td><td>36</td><td>(14)</td><td>(17)</td></tr><tr><td>Oncology</td><td>602</td><td>23</td><td>17</td><td>313</td><td>14</td><td>3</td><td>253</td><td>30</td><td>31</td><td>36</td><td>80</td><td>75</td></tr><tr><td>Zejula</td><td>463</td><td>17</td><td>12</td><td>235</td><td>11</td><td>-</td><td>194</td><td>19</td><td>20</td><td>34</td><td>70</td><td>75</td></tr><tr><td>Blenrep</td><td>118</td><td>33</td><td>25</td><td>66</td><td>8</td><td>(3)</td><td>52</td><td>86</td><td>86</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Jemperli</td><td>21</td><td>&gt;100</td><td>&gt;100</td><td>13</td><td>&gt;100</td><td>&gt;100</td><td>8</td><td>&gt;100</td><td>&gt;100</td><td>-</td><td>-</td><td>-</td></tr><tr><td>Other</td><td>-</td><td>-</td><td>-</td><td>(1)</td><td>-</td><td>-</td><td>(1)</td><td>-</td><td>-</td><td>2</td><td>-</td><td>-</td></tr><tr><td>Immuno-inflamm. respiratory and other</td><td>2,609</td><td>29</td><td>20</td><td>1,830</td><td>29</td><td>16</td><td>366</td><td>13</td><td>13</td><td>413</td><td>45</td><td>47</td></tr><tr><td>Benlysta</td><td>1,146</td><td>31</td><td>20</td><td>949</td><td>31</td><td>18</td><td>83</td><td>22</td><td>22</td><td>114</td><td>44</td><td>43</td></tr><tr><td>Nucala</td><td>1,423</td><td>25</td><td>18</td><td>881</td><td>28</td><td>15</td><td>300</td><td>17</td><td>17</td><td>242</td><td>24</td><td>28</td></tr><tr><td>Other</td><td>40</td><td>&gt;100</td><td>&gt;100</td><td>-</td><td>-</td><td>-</td><td>(17)</td><td>-</td><td>-</td><td>57</td><td>&gt;100</td><td>&gt;100</td></tr><tr><td>Specialty Medicines excl. pandemic</td><td>8,960</td><td>23</td><td>15</td><td>5,899</td><td>29</td><td>16</td><td>1,929</td><td>13</td><td>13</td><td>1,132</td><td>14</td><td>13</td></tr><tr><td>Pandemic</td><td>2,309</td><td>&gt;100</td><td>&gt;100</td><td>828</td><td>38</td><td>24</td><td>456</td><td>&gt;100</td><td>&gt;100</td><td>1,025</td><td>&gt;100</td><td>&gt;100</td></tr><tr><td>Xevudy</td><td>2,309</td><td>&gt;100</td><td>&gt;100</td><td>828</td><td>38</td><td>24</td><td>456</td><td>&gt;100</td><td>&gt;100</td><td>1,025</td><td>&gt;100</td><td>&gt;100</td></tr><tr><td>Specialty Medicines</td><td>11,269</td><td>37</td><td>29</td><td>6,727</td><td>30</td><td>17</td><td>2,385</td><td>34</td><td>35</td><td>2,157</td><td>69</td><td>70</td></tr><tr><td>Meningitis</td><td>1,116</td><td>16</td><td>11</td><td>573</td><td>26</td><td>14</td><td>362</td><td>2</td><td>3</td><td>181</td><td>18</td><td>20</td></tr><tr><td>Bexsero</td><td>753</td><td>16</td><td>12</td><td>333</td><td>32</td><td>19</td><td>337</td><td>3</td><td>4</td><td>83</td><td>20</td><td>23</td></tr><tr><td>Menveo</td><td>345</td><td>27</td><td>18</td><td>240</td><td>20</td><td>8</td><td>20</td><td>(5)</td><td>(10)</td><td>85</td><td>67</td><td>71</td></tr><tr><td>Other</td><td>18</td><td>(54)</td><td>(54)</td><td>-</td><td>-</td><td>-</td><td>5</td><td>-</td><td>-</td><td>13</td><td>(62)</td><td>(62)</td></tr><tr><td>Influenza</td><td>714</td><td>5</td><td>(4)</td><td>549</td><td>20</td><td>9</td><td>57</td><td>(44)</td><td>(44)</td><td>108</td><td>(11)</td><td>(16)</td></tr><tr><td>Fluarix/Flulaval</td><td>714</td><td>5</td><td>(4)</td><td>549</td><td>20</td><td>9</td><td>57</td><td>(44)</td><td>(44)</td><td>108</td><td>(11)</td><td>(16)</td></tr><tr><td>Shingles</td><td>2,958</td><td>72</td><td>60</td><td>1,964</td><td>46</td><td>32</td><td>688</td><td>&gt;100</td><td>&gt;100</td><td>306</td><td>&gt;100</td><td>&gt;100</td></tr><tr><td>Shringrix</td><td>2,958</td><td>72</td><td>60</td><td>1,964</td><td>46</td><td>32</td><td>688</td><td>&gt;100</td><td>&gt;100</td><td>306</td><td>&gt;100</td><td>&gt;100</td></tr><tr><td>Established vaccines</td><td>3,085</td><td>4</td><td>-</td><td>1,157</td><td>18</td><td>7</td><td>720</td><td>3</td><td>4</td><td>1,208</td><td>(7)</td><td>8</td></tr><tr><td>Infanrix, Pediarix</td><td>594</td><td>9</td><td>3</td><td>327</td><td>8</td><td>(3)</td><td>131</td><td>13</td><td>13</td><td>136</td><td>10</td><td>6</td></tr><tr><td>Boostrix</td><td>594</td><td>14</td><td>7</td><td>360</td><td>33</td><td>20</td><td>138</td><td>(1)</td><td>(1)</td><td>96</td><td>(14)</td><td>(15)</td></tr><tr><td>Hepatitis</td><td>571</td><td>24</td><td>16</td><td>343</td><td>28</td><td>15</td><td>142</td><td>30</td><td>31</td><td>86</td><td>5</td><td>(1)</td></tr><tr><td>Rotarix</td><td>527</td><td>(3)</td><td>(3)</td><td>95</td><td>(14)</td><td>(23)</td><td>122</td><td>3</td><td>5</td><td>310</td><td>(1)</td><td>1</td></tr><tr><td>Synflorix</td><td>305</td><td>(15)</td><td>(15)</td><td>-</td><td>-</td><td>-</td><td>34</td><td>(24)</td><td>(22)</td><td>271</td><td>(13)</td><td>(14)</td></tr><tr><td>Priorix, Priorix Tetra, Varilrix</td><td>188</td><td>(28)</td><td>(29)</td><td>10</td><td>-</td><td>-</td><td>97</td><td>(22)</td><td>(22)</td><td>81</td><td>(40)</td><td>(43)</td></tr><tr><td>Cervarix</td><td>117</td><td>(15)</td><td>(20)</td><td>-</td><td>-</td><td>-</td><td>22</td><td>(12)</td><td>(8)</td><td>95</td><td>(16)</td><td>(22)</td></tr><tr><td>Others</td><td>189</td><td>26</td><td>26</td><td>22</td><td>(8)</td><td>(17)</td><td>34</td><td>55</td><td>45</td><td>133</td><td>28</td><td>32</td></tr><tr><td>Vaccines excluding pandemic</td><td>7,873</td><td>24</td><td>17</td><td>4,243</td><td>31</td><td>18</td><td>1,827</td><td>27</td><td>28</td><td>1,803</td><td>8</td><td>6</td></tr><tr><td>Pandemic vaccines</td><td>64</td><td>(86)</td><td>(86)</td><td>-</td><td>(100)</td><td>(100)</td><td>57</td><td>-</td><td>-</td><td>7</td><td>(97)</td><td>(97)</td></tr><tr><td>Pandemic adjuvant</td><td>64</td><td>(86)</td><td>(86)</td><td>-</td><td>(100)</td><td>(100)</td><td>57</td><td>-</td><td>-</td><td>7</td><td>(97)</td><td>(97)</td></tr><tr><td>Vaccines</td><td>7937</td><td>17</td><td>11</td><td>4,243</td><td>22</td><td>10</td><td>1,884</td><td>31</td><td>32</td><td>1,810</td><td>(3)</td><td>(5)</td></tr><tr><td>Respiratory</td><td>6,548</td><td>8</td><td>3</td><td>3,209</td><td>10</td><td>(1)</td><td>1,384</td><td>3</td><td>3</td><td>1,955</td><td>10</td><td>9</td></tr><tr><td>Amnity Ellipta</td><td>56</td><td>19</td><td>9</td><td>48</td><td>20</td><td>10</td><td>-</td><td>-</td><td>-</td><td>8</td><td>14</td><td>-</td></tr><tr><td>Anoro Ellipta</td><td>483</td><td>(4)</td><td>(9)</td><td>233</td><td>(16)</td><td>(24)</td><td>165</td><td>11</td><td>11</td><td>85</td><td>10</td><td>10</td></tr><tr><td>Avamys/Veramyst</td><td>321</td><td>8</td><td>6</td><td>-</td><td>-</td><td>-</td><td>65</td><td>-</td><td>2</td><td>256</td><td>10</td><td>8</td></tr><tr><td>Flixotide/Flovent</td><td>545</td><td>23</td><td>15</td><td>353</td><td>28</td><td>16</td><td>74</td><td>7</td><td>7</td><td>118</td><td>18</td><td>16</td></tr><tr><td>Incurse Ellipta</td><td>196</td><td>(4)</td><td>(10)</td><td>104</td><td>(5)</td><td>(14)</td><td>64</td><td>(9)</td><td>(7)</td><td>28</td><td>8</td><td>-</td></tr><tr><td>Relvar/Breo Ellipta</td><td>1,145</td><td>2</td><td>(2)</td><td>498</td><td>2</td><td>(8)</td><td>347</td><td>4</td><td>4</td><td>300</td><td>-</td><td>2</td></tr><tr><td>Seretide/Advair</td><td>1,159</td><td>(15)</td><td>(17)</td><td>308</td><td>(37)</td><td>(43)</td><td>287</td><td>(11)</td><td>(11)</td><td>564</td><td>3</td><td>1</td></tr><tr><td>Trelegy Ellipta</td><td>1,729</td><td>42</td><td>32</td><td>1,253</td><td>47</td><td>32</td><td>236</td><td>18</td><td>19</td><td>240</td><td>47</td><td>48</td></tr><tr><td>Ventolin</td><td>771</td><td>7</td><td>2</td><td>411</td><td>5</td><td>(5)</td><td>116</td><td>7</td><td>8</td><td>244</td><td>11</td><td>10</td></tr><tr><td>Other Respiratory</td><td>143</td><td>4</td><td>6</td><td>1</td><td>-</td><td>-</td><td>30</td><td>11</td><td>7</td><td>112</td><td>2</td><td>5</td></tr><tr><td>Other General Medicines</td><td>3,570</td><td>(1)</td><td>(2)</td><td>363</td><td>10</td><td>(1)</td><td>695</td><td>(14)</td><td>(13)</td><td>2,512</td><td>1</td><td>2</td></tr><tr><td>Dermatology</td><td>376</td><td>(6)</td><td>(5)</td><td>(1)</td><td>-</td><td>-</td><td>107</td><td>(18)</td><td>(18)</td><td>270</td><td>-</td><td>1</td></tr><tr><td>Augmentin</td><td>576</td><td>35</td><td>38</td><td>-</td><td>-</td><td>-</td><td>151</td><td>22</td><td>23</td><td>425</td><td>41</td><td>44</td></tr><tr><td>Avodart</td><td>330</td><td>(1)</td><td>(3)</td><td>-</td><td>-</td><td>-</td><td>107</td><td>(9)</td><td>(8)</td><td>223</td><td>5</td><td>-</td></tr><tr><td>Lamictal</td><td>511</td><td>7</td><td>1</td><td>265</td><td>14</td><td>3</td><td>109</td><td>(3)</td><td>(3)</td><td>137</td><td>2</td><td>-</td></tr><tr><td>Other</td><td>1,777</td><td>(10)</td><td>(10)</td><td>99</td><td>-</td><td>(9)</td><td>221</td><td>(31)</td><td>(31)</td><td>1,457</td><td>(7)</td><td>(6)</td></tr><tr><td>General Medicines</td><td>10,118</td><td>5</td><td>1</td><td>3,572</td><td>10</td><td>(1)</td><td>2,079</td><td>(3)</td><td>(3)</td><td>4,467</td><td>5</td><td>5</td></tr><tr><td>Total Commercial Operations</td><td>29,324</td><td>19</td><td>13</td><td>14,542</td><td>22</td><td>10</td><td>6,348</td><td>18</td><td>19</td><td>8,434</td><td>14</td><td>14</td></tr></table>



Commercial Operations turnover by therapeutic area 2021

<table><tr><td rowspan="3"></td><td colspan="4">Total</td><td colspan="4">US</td><td colspan="4">Europe</td><td colspan="4">International</td></tr><tr><td colspan="2">2021</td><td colspan="2">Growth</td><td colspan="2">2021</td><td colspan="2">Growth</td><td colspan="2" valign="top">2021</td><td colspan="2">Growth</td><td colspan="2" valign="bottom">2021</td><td colspan="2">Growth</td></tr><tr><td>£m</td><td>£%</td><td>CER%</td><td>£m</td><td>£%</td><td>CER%</td><td>£m</td><td>£%</td><td>C</td><td>ER%</td><td>£m</td><td>£%</td><td>C</td><td>ER%</td><td>£</td><td>ER%</td></tr><tr><td>HIV</td><td>4,777</td><td>(2)</td><td>3</td><td>2,898</td><td>(4)</td><td>3</td><td>1,194</td><td>(2)</td><td>1</td><td>685</td><td>4</td><td>11</td><td></td><td></td><td></td><td></td></tr><tr><td>Dolutegravir products</td><td>4,567</td><td>(3)</td><td>2</td><td>2,774</td><td>(6)</td><td>-</td><td>1,151</td><td>(1)</td><td>1</td><td>642</td><td>7</td><td>14</td><td></td><td></td><td></td><td></td></tr><tr><td>Tivicay</td><td>1,381</td><td>(10)</td><td>(4)</td><td>763</td><td>(12)</td><td>(7)</td><td>286</td><td>(22)</td><td>(20)</td><td>332</td><td>15</td><td>24</td><td></td><td></td><td></td><td></td></tr><tr><td>Trumeq</td><td>1,882</td><td>(18)</td><td>(14)</td><td>1,190</td><td>(18)</td><td>(13)</td><td>452</td><td>(20)</td><td>(18)</td><td>240</td><td>(15)</td><td>(12)</td><td></td><td></td><td></td><td></td></tr><tr><td>Juluca</td><td>517</td><td>4</td><td>10</td><td>393</td><td>2</td><td>8</td><td>111</td><td>14</td><td>18</td><td>13</td><td>18</td><td>27</td><td></td><td></td><td></td><td></td></tr><tr><td>Dovato</td><td>787</td><td>100</td><td>100</td><td>428</td><td>87</td><td>99</td><td>302</td><td>100</td><td>100</td><td>57</td><td>100</td><td>100</td><td></td><td></td><td></td><td></td></tr><tr><td>Rukobia</td><td>45</td><td>100</td><td>100</td><td>43</td><td>100</td><td>100</td><td>2</td><td>100</td><td>100</td><td>-</td><td>-</td><td>-</td><td></td><td></td><td></td><td></td></tr><tr><td>Cabenuva</td><td>38</td><td>100</td><td>100</td><td>32</td><td>-</td><td>-</td><td>5</td><td>-</td><td>-</td><td>1</td><td>100</td><td>100</td><td></td><td></td><td></td><td></td></tr><tr><td>Apretude</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>(28)</td><td>(26)</td><td>42</td><td>(30)</td><td>(23)</td><td></td><td></td><td></td><td></td></tr><tr><td>Others</td><td>127</td><td>(22)</td><td>(18)</td><td>49</td><td>(8)</td><td>(4)</td><td>36</td><td>(28)</td><td>(26)</td><td>42</td><td>(30)</td><td>(23)</td><td></td><td></td><td></td><td></td></tr><tr><td>Oncology</td><td>489</td><td>31</td><td>37</td><td>274</td><td>19</td><td>26</td><td>195</td><td>43</td><td>46</td><td>20</td><td>100</td><td>100</td><td></td><td></td><td></td><td></td></tr><tr><td>Zejula</td><td>395</td><td>17</td><td>22</td><td>212</td><td>3</td><td>10</td><td>163</td><td>27</td><td>30</td><td>20</td><td>100</td><td>100</td><td></td><td></td><td></td><td></td></tr><tr><td>Blenrep</td><td>89</td><td>100</td><td>100</td><td>61</td><td>100</td><td>100</td><td>28</td><td>100</td><td>100</td><td>-</td><td>-</td><td>-</td><td></td><td></td><td></td><td></td></tr><tr><td>Jemperli</td><td>5</td><td>100</td><td>100</td><td>2</td><td>-</td><td>-</td><td>3</td><td>100</td><td>100</td><td>-</td><td>-</td><td>-</td><td></td><td></td><td></td><td></td></tr><tr><td>Other</td><td>-</td><td>-</td><td>-</td><td>(1)</td><td>(100)</td><td>(100)</td><td>1</td><td>100</td><td>(100)</td><td>-</td><td>-</td><td>-</td><td></td><td></td><td></td><td></td></tr><tr><td>Immuno-Inflamm. respiratory and other</td><td>2,027</td><td>18</td><td>25</td><td>1,417</td><td>17</td><td>25</td><td>325</td><td>11</td><td>13</td><td>285</td><td>31</td><td>41</td><td></td><td></td><td></td><td></td></tr><tr><td>Benlysta</td><td>874</td><td>22</td><td>29</td><td>727</td><td>19</td><td>26</td><td>68</td><td>21</td><td>25</td><td>79</td><td>55</td><td>67</td><td></td><td></td><td></td><td></td></tr><tr><td>Nucala</td><td>1,142</td><td>15</td><td>22</td><td>690</td><td>15</td><td>23</td><td>257</td><td>8</td><td>11</td><td>195</td><td>23</td><td>34</td><td></td><td></td><td></td><td></td></tr><tr><td>Other</td><td>11</td><td>38</td><td>38</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>11</td><td>38</td><td>38</td><td></td><td></td><td></td><td></td></tr><tr><td>Specialty Medicines excl. pandemic</td><td>7,293</td><td>5</td><td>10</td><td>4,589</td><td>3</td><td>10</td><td>1,714</td><td>4</td><td>7</td><td>990</td><td>12</td><td>20</td><td></td><td></td><td></td><td></td></tr><tr><td>Pandemic</td><td>958</td><td>-</td><td>-</td><td>602</td><td>-</td><td>-</td><td>69</td><td>-</td><td>-</td><td>287</td><td>-</td><td>-</td><td></td><td></td><td></td><td></td></tr><tr><td>Xevudy</td><td>958</td><td>-</td><td>-</td><td>602</td><td>-</td><td>-</td><td>69</td><td>-</td><td>-</td><td>287</td><td>-</td><td>-</td><td></td><td></td><td></td><td></td></tr><tr><td>Specialty Medicines</td><td>8,251</td><td>18</td><td>25</td><td>5,191</td><td>17</td><td>24</td><td>1,783</td><td>9</td><td>11</td><td>1,277</td><td>45</td><td>55</td><td></td><td></td><td></td><td></td></tr><tr><td>Meningitis</td><td>961</td><td>(7)</td><td>(2)</td><td>453</td><td>5</td><td>11</td><td>354</td><td>(1)</td><td>2</td><td>154</td><td>(36)</td><td>(30)</td><td></td><td></td><td></td><td></td></tr><tr><td>Bexsero</td><td>650</td><td>-</td><td>5</td><td>253</td><td>(3)</td><td>3</td><td>328</td><td>1</td><td>4</td><td>69</td><td>5</td><td>20</td><td></td><td></td><td></td><td></td></tr><tr><td>Menveo</td><td>272</td><td>3</td><td>9</td><td>200</td><td>16</td><td>23</td><td>21</td><td>(19)</td><td>(15)</td><td>51</td><td>(23)</td><td>(18)</td><td></td><td></td><td></td><td></td></tr><tr><td>Other</td><td>39</td><td>(66)</td><td>(65)</td><td>-</td><td>-</td><td>-</td><td>5</td><td>(17)</td><td>(17)</td><td>34</td><td>(69)</td><td>(68)</td><td></td><td></td><td></td><td></td></tr><tr><td>Influenza</td><td>679</td><td>(7)</td><td>(2)</td><td>456</td><td>(15)</td><td>(9)</td><td>101</td><td>3</td><td>6</td><td>122</td><td>22</td><td>28</td><td></td><td></td><td></td><td></td></tr><tr><td>Fluarix/Flulaval</td><td>679</td><td>(7)</td><td>(2)</td><td>456</td><td>(15)</td><td>(9)</td><td>101</td><td>3</td><td>6</td><td>122</td><td>22</td><td>28</td><td></td><td></td><td></td><td></td></tr><tr><td>Shingles</td><td>1,721</td><td>(13)</td><td>(9)</td><td>1,344</td><td>(20)</td><td>(15)</td><td>281</td><td>51</td><td>54</td><td>96</td><td>(25)</td><td>(23)</td><td></td><td></td><td></td><td></td></tr><tr><td>Shringrix</td><td>1,721</td><td>(13)</td><td>(9)</td><td>1,344</td><td>(20)</td><td>(15)</td><td>281</td><td>51</td><td>54</td><td>96</td><td>(25)</td><td>(23)</td><td></td><td></td><td></td><td></td></tr><tr><td>Established vaccines</td><td>2,970</td><td>(8)</td><td>(4)</td><td>977</td><td>(7)</td><td>(1)</td><td>700</td><td>(13)</td><td>(10)</td><td>1,293</td><td>(6)</td><td>(3)</td><td></td><td></td><td></td><td></td></tr><tr><td>Infanrix, Pediarix</td><td>543</td><td>(14)</td><td>(9)</td><td>303</td><td>(3)</td><td>4</td><td>116</td><td>(33)</td><td>(32)</td><td>124</td><td>(14)</td><td>(10)</td><td></td><td></td><td></td><td></td></tr><tr><td>Boostrix</td><td>521</td><td>9</td><td>14</td><td>270</td><td>5</td><td>12</td><td>140</td><td>-</td><td>2</td><td>111</td><td>41</td><td>44</td><td></td><td></td><td></td><td></td></tr><tr><td>Hepatitis</td><td>460</td><td>(20)</td><td>(16)</td><td>269</td><td>(19)</td><td>(14)</td><td>109</td><td>(22)</td><td>(21)</td><td>82</td><td>(20)</td><td>(17)</td><td></td><td></td><td></td><td></td></tr><tr><td>Rotarix</td><td>541</td><td>(3)</td><td>1</td><td>111</td><td>(10)</td><td>(4)</td><td>118</td><td>(1)</td><td>2</td><td>312</td><td>(2)</td><td>3</td><td></td><td></td><td></td><td></td></tr><tr><td>Synflorix</td><td>357</td><td>(11)</td><td>(8)</td><td>-</td><td>-</td><td>-</td><td>45</td><td>(15)</td><td>(13)</td><td>312</td><td>(11)</td><td>(7)</td><td></td><td></td><td></td><td></td></tr><tr><td>Priorix, Priorix Tetra, Varilrix</td><td>260</td><td>-</td><td>4</td><td>-</td><td>-</td><td>-</td><td>125</td><td>(1)</td><td>2</td><td>135</td><td>-</td><td>5</td><td></td><td></td><td></td><td></td></tr><tr><td>Cervarix</td><td>138</td><td>(1)</td><td>-</td><td>-</td><td>-</td><td>-</td><td>25</td><td>(17)</td><td>(17)</td><td>113</td><td>4</td><td>5</td><td></td><td></td><td></td><td></td></tr><tr><td>Others</td><td>150</td><td>(21)</td><td>(19)</td><td>24</td><td>(20)</td><td>(13)</td><td>22</td><td>16</td><td>26</td><td>104</td><td>(26)</td><td>(26)</td><td></td><td></td><td></td><td></td></tr><tr><td>Vaccines excluding pandemic</td><td>6,331</td><td>(9)</td><td>(5)</td><td>3,230</td><td>(13)</td><td>(7)</td><td>1,436</td><td>-</td><td>2</td><td>1,665</td><td>(10)</td><td>(6)</td><td></td><td></td><td></td><td></td></tr><tr><td>Pandemic vaccines</td><td>447</td><td>-</td><td>-</td><td>242</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>205</td><td>-</td><td>-</td><td></td><td></td><td></td><td></td></tr><tr><td>Pandemic adjuvant</td><td>444</td><td>-</td><td>-</td><td>242</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>202</td><td>-</td><td>-</td><td></td><td></td><td></td><td></td></tr><tr><td>Others</td><td>3</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>-</td><td>3</td><td>-</td><td>-</td><td>-</td><td></td><td></td><td></td><td></td></tr><tr><td>Vaccines</td><td>6,778</td><td>(3)</td><td>2</td><td>3,472</td><td>(6)</td><td>-</td><td>1,436</td><td>-</td><td>2</td><td>1,870</td><td>1</td><td>5</td><td></td><td></td><td></td><td></td></tr><tr><td>Respiratory</td><td>6,048</td><td>1</td><td>6</td><td>2,920</td><td>14</td><td>21</td><td>1,344</td><td>(7)</td><td>(5)</td><td>1,784</td><td>(11)</td><td>(5)</td><td></td><td></td><td></td><td></td></tr><tr><td>Amuriy Ellipta</td><td>47</td><td>4</td><td>11</td><td>40</td><td>8</td><td>16</td><td>-</td><td>-</td><td>-</td><td>7</td><td>(12)</td><td>(13)</td><td></td><td></td><td></td><td></td></tr><tr><td>Anoro Ellipta</td><td>504</td><td>(8)</td><td>(3)</td><td>278</td><td>(15)</td><td>(9)</td><td>149</td><td>5</td><td>8</td><td>77</td><td>(1)</td><td>3</td><td></td><td></td><td></td><td></td></tr><tr><td>Avamys/Veramyst</td><td>298</td><td>-</td><td>7</td><td>-</td><td>-</td><td>-</td><td>65</td><td>(2)</td><td>2</td><td>233</td><td>1</td><td>8</td><td></td><td></td><td></td><td></td></tr><tr><td>Flixotide/Flovent</td><td>444</td><td>6</td><td>12</td><td>275</td><td>50</td><td>60</td><td>69</td><td>(14)</td><td>(11)</td><td>100</td><td>(36)</td><td>(32)</td><td></td><td></td><td></td><td></td></tr><tr><td>Incrusse Ellipta</td><td>205</td><td>(7)</td><td>(3)</td><td>109</td><td>(7)</td><td>(2)</td><td>70</td><td>(5)</td><td>(3)</td><td>26</td><td>(10)</td><td>(7)</td><td></td><td></td><td></td><td></td></tr><tr><td>Relvar/Breo Ellipta</td><td>1,121</td><td>-</td><td>5</td><td>488</td><td>3</td><td>9</td><td>334</td><td>4</td><td>6</td><td>299</td><td>(9)</td><td>(2)</td><td></td><td></td><td></td><td></td></tr><tr><td>Seretide/Advair</td><td>1,357</td><td>(12)</td><td>(7)</td><td>486</td><td>12</td><td>19</td><td>322</td><td>(28)</td><td>(27)</td><td>549</td><td>(16)</td><td>(11)</td><td></td><td></td><td></td><td></td></tr><tr><td>Trelegy Ellipta</td><td>1,217</td><td>49</td><td>57</td><td>854</td><td>52</td><td>62</td><td>200</td><td>19</td><td>21</td><td>163</td><td>81</td><td>92</td><td></td><td></td><td></td><td></td></tr><tr><td>Ventolin</td><td>718</td><td>(9)</td><td>(4)</td><td>390</td><td>(9)</td><td>(3)</td><td>108</td><td>(7)</td><td>(5)</td><td>220</td><td>(8)</td><td>(3)</td><td></td><td></td><td></td><td></td></tr><tr><td>Other Respiratory</td><td>137</td><td>(36)</td><td>(31)</td><td>-</td><td>-</td><td>-</td><td>27</td><td>-</td><td>-</td><td>110</td><td>(41)</td><td>(36)</td><td></td><td></td><td></td><td></td></tr><tr><td>Other General Medicines</td><td>3,619</td><td>(15)</td><td>(15)</td><td>331</td><td>(25)</td><td>(20)</td><td>807</td><td>(21)</td><td>(19)</td><td>2,481</td><td>(12)</td><td>(13)</td><td></td><td></td><td></td><td></td></tr><tr><td>Dermatology</td><td>399</td><td>(6)</td><td>(1)</td><td>(1)</td><td>×(100)</td><td>×(100)</td><td>131</td><td>(6)</td><td>(4)</td><td>269</td><td>(5)</td><td>2</td><td></td><td></td><td></td><td></td></tr><tr><td>Augmentin</td><td>426</td><td>(13)</td><td>(7)</td><td>-</td><td>-</td><td>-</td><td>124</td><td>(14)</td><td>(12)</td><td>302</td><td>(12)</td><td>(4)</td><td></td><td></td><td></td><td></td></tr><tr><td>Avodart</td><td>332</td><td>(29)</td><td>(25)</td><td>11</td><td>(80)</td><td>(80)</td><td>118</td><td>(25)</td><td>(23)</td><td>213</td><td>(30)</td><td>(25)</td><td></td><td></td><td></td><td></td></tr><tr><td>Lamictal</td><td>478</td><td>(11)</td><td>(6)</td><td>232</td><td>(14)</td><td>(9)</td><td>112</td><td>(7)</td><td>(5)</td><td>134</td><td>(9)</td><td>(3)</td><td></td><td></td><td></td><td></td></tr><tr><td>Other</td><td>1984</td><td>(16)</td><td>(19)</td><td>99</td><td>(40)</td><td>(36)</td><td>322</td><td>(29)</td><td>(27)</td><td>1,563</td><td>(10)</td><td>(16)</td><td></td><td></td><td></td><td></td></tr><tr><td>General Medicines</td><td>9,667</td><td>(6)</td><td>(3)</td><td>3,251</td><td>8</td><td>15</td><td>2,151</td><td>(13)</td><td>(11)</td><td>4,265</td><td>(11)</td><td>(10)</td><td></td><td></td><td></td><td></td></tr><tr><td>Total Commercial Operations</td><td>24,696</td><td>1</td><td>6</td><td>11,914</td><td>7</td><td>14</td><td>5,370</td><td>(3)</td><td>(1)</td><td>7,412</td><td>(3)</td><td>-</td><td></td><td></td><td></td><td></td></tr></table>



## Three-year selected financial data

A record of financial performance is provided, analysed in accordance with current reporting practice. The information included in the selected financial data (except for number of employees and adjusted results) is prepared in accordance with International Accounting Standards in conformity with the requirements of the Companies Act 2006 and also with IFRS as issued by the International Accounting Standards Board. Three year financial data is presented reflecting the restated results following the demerger of the Consumer Healthcare business. The financial results of 2019 and 2018 are not restated and are not presented here.

<table><tr><td>Group turnover by geographic region</td><td>2022
£m</td><td>2021
(revised) \( ^{(1)} \) 
£m</td><td>2020
(revised) \( ^{(1)} \) 
£m</td></tr><tr><td>US</td><td>14,542</td><td>11,914</td><td>11,148</td></tr><tr><td>Europe</td><td>6,348</td><td>5,370</td><td>5,545</td></tr><tr><td>International</td><td>8,434</td><td>7,412</td><td>7,661</td></tr><tr><td></td><td>29,324</td><td>24,696</td><td>24,354</td></tr><tr><td></td><td>2022
£m</td><td>2021
(revised) \( ^{(1)} \) 
£m</td><td>2020
(revised) \( ^{(1)} \) 
£m</td></tr><tr><td>Group turnover by product group</td><td></td><td></td><td></td></tr><tr><td>Specialty Medicines</td><td>11,269</td><td>8,251</td><td>6,969</td></tr><tr><td>Vaccines</td><td>7937</td><td>6,778</td><td>6,982</td></tr><tr><td>General Medicines</td><td>10,118</td><td>9,667</td><td>10,281</td></tr><tr><td>Consumer Healthcare \( ^{(2)} \)</td><td>-</td><td>-</td><td>122</td></tr><tr><td></td><td>29,324</td><td>24,696</td><td>24,354</td></tr><tr><td></td><td>2022
£m</td><td>2021
(revised) \( ^{(1)} \) 
£m</td><td>2020
(revised) \( ^{(1)} \) 
£m</td></tr><tr><td>Specialty Medicines turnover</td><td></td><td></td><td></td></tr><tr><td>HIV</td><td>5,749</td><td>4,777</td><td>4,876</td></tr><tr><td>Oncology</td><td>602</td><td>489</td><td>372</td></tr><tr><td>Immuno-inflammation and other</td><td>2,609</td><td>2,027</td><td>1,721</td></tr><tr><td>Pandemic</td><td>2,309</td><td>958</td><td>-</td></tr><tr><td></td><td>11,269</td><td>8,251</td><td>6,969</td></tr><tr><td></td><td>2022
£m</td><td>2021
£m</td><td>2020
£m</td></tr><tr><td>Vaccines turnover</td><td></td><td></td><td></td></tr><tr><td>Meningitis</td><td>1,116</td><td>961</td><td>1,029</td></tr><tr><td>Influenza</td><td>714</td><td>679</td><td>733</td></tr><tr><td>Shingles</td><td>2,958</td><td>1,721</td><td>1,989</td></tr><tr><td>Established Vaccines</td><td>3,085</td><td>2,970</td><td>3,231</td></tr><tr><td>Pandemic Vaccines</td><td>64</td><td>447</td><td>-</td></tr><tr><td></td><td>7937</td><td>6,778</td><td>6,982</td></tr><tr><td></td><td>2022
£m</td><td>2021
£m</td><td>2020
£m</td></tr><tr><td>General Medicines</td><td></td><td></td><td></td></tr><tr><td>Respiratory</td><td>6,548</td><td>6,048</td><td>6,006</td></tr><tr><td>Other General Medicines</td><td>3,570</td><td>3,619</td><td>4,275</td></tr><tr><td></td><td>10,118</td><td>9,667</td><td>10,281</td></tr><tr><td></td><td>2022
£m</td><td>2021
£m</td><td>2020
£m</td></tr><tr><td>Financial results - Total</td><td></td><td></td><td></td></tr><tr><td>Turnover</td><td>29,324</td><td>24,696</td><td>24,354</td></tr><tr><td>Profit after taxation from continuing operations</td><td>4,921</td><td>3,516</td><td>5,103</td></tr><tr><td>Profit after taxation from discontinued operations and other gains/(losses) from the demerger</td><td>3,049</td><td>1,580</td><td>1,285</td></tr><tr><td>Remeasurement of discontinued operations distributed to shareholders on demerger</td><td>7,651</td><td>-</td><td>-</td></tr><tr><td>Profit after taxation from discontinued operations</td><td>10,700</td><td>1,580</td><td>1,285</td></tr><tr><td>Profit after taxation for the year</td><td>15,621</td><td>5,096</td><td>6,388</td></tr><tr><td></td><td>pence</td><td>pence \( ^{(3)} \)</td><td>pence \( ^{(3)} \)</td></tr><tr><td>Basic earnings per share from continuing operations</td><td>110.8p</td><td>829p</td><td>122.4p</td></tr><tr><td>Basic earnings per share from discontinued operations</td><td>260.6p</td><td>26.7p</td><td>22.0p</td></tr><tr><td>Total basic earnings per share</td><td>371.4p</td><td>109.6p</td><td>144.4p</td></tr><tr><td>Diluted earnings per share from continuing operations</td><td>109.2p</td><td>81.8p</td><td>120.9p</td></tr><tr><td>Diluted earnings per share from discontinued operations</td><td>257.0p</td><td>26.4p</td><td>21.7p</td></tr><tr><td>Total diluted earnings per share</td><td>366.2p</td><td>108.2p</td><td>142.6p</td></tr></table>

(1) GSK has revised its operating segments during the year. See Note 6 to the consolidated financial statements for more details.

(2) On 1 April 2020, GSK completed its divestment of Horlicks and other Consumer Healthcare nutrition products in India and a number of other countries (excluding Bangladesh) to Unilever and the merger of GSK's Indian listed Consumer Healthcare entity with Hindustan Unilever, an Indian listed public company, GSK completed the divestment of Bangladesh on 30 June 2020.

(3) The 2021 and 2020 comparatives have been restated on a consistent basis from those previously published to reflect the demerger of the Consumer Healthcare business (see Note 4I) and the impact of Share Consolidation (see Note 37) of the consolidated financial statements.



## Financial record continued

## Three year selected financial data continued

<table><tr><td></td><td>2022</td><td>2021 \( ^{(1)} \)</td><td>2020 \( ^{(1)} \)</td></tr><tr><td>Financial results – Adjusted</td><td>£m</td><td>£m</td><td>£m</td></tr><tr><td>Turnover</td><td>29,324</td><td>24,696</td><td>24,354</td></tr><tr><td>Continuing operating profit</td><td>8,151</td><td>6,493</td><td>6,656</td></tr><tr><td>Continuing profit before taxation</td><td>7,358</td><td>5,774</td><td>5,851</td></tr><tr><td>Continuing profit after taxation</td><td>6,220</td><td>4,856</td><td>5,035</td></tr></table>

The reconciliations between Total and Adjusted operating profit over the last three years can be summarised as follows:

<table><tr><td></td><td>2022</td><td>2021 \( ^{(1)} \)</td><td>2020 \( ^{(1)} \)</td></tr><tr><td></td><td>£m</td><td>£m</td><td>£m</td></tr><tr><td>Total continuing operating profit</td><td>6,433</td><td>4,357</td><td>5,979</td></tr><tr><td>Intangible asset amortisation</td><td>739</td><td>761</td><td>724</td></tr><tr><td>Intangible asset impairment</td><td>296</td><td>347</td><td>200</td></tr><tr><td>Major restructuring</td><td>321</td><td>424</td><td>1,178</td></tr><tr><td>Transaction-related items</td><td>1,750</td><td>1,143</td><td>1,237</td></tr><tr><td>Divestments, significant legal and other items</td><td>(1,388)</td><td>(539)</td><td>(2,662)</td></tr><tr><td>Adjusted continuing operating profit</td><td>8,151</td><td>6,493</td><td>6,656</td></tr></table>

The reconciliation between total and Adjusted earnings per share over the last three years can be summarised as follows:

<table><tr><td></td><td>pence</td><td>pence \( ^{(1)} \)</td><td>pence \( ^{(1)} \)</td></tr><tr><td>Total continuing earnings per share</td><td>110.8p</td><td>82.9p</td><td>122.4p</td></tr><tr><td>Intangible asset amortisation</td><td>14.6p</td><td>15.2p</td><td>14.6p</td></tr><tr><td>Intangible asset impairment</td><td>5.8p</td><td>6.6p</td><td>4.1p</td></tr><tr><td>Major restructuring</td><td>5.9p</td><td>8.7p</td><td>24.3p</td></tr><tr><td>Transaction-related items</td><td>34.1p</td><td>18.1p</td><td>19.0p</td></tr><tr><td>Divestments, significant legal and other items</td><td>(31.5)p</td><td>(21.2)p</td><td>(70.0)p</td></tr><tr><td>Adjusted continuing earnings per share</td><td>139.7p</td><td>110.3p</td><td>114.4p</td></tr><tr><td></td><td>%</td><td>%</td><td>%</td></tr><tr><td>Return on capital employed</td><td>n/m</td><td>25.8</td><td>35.6</td></tr></table>

For 2021 and 2022 return on capital employed is calculated as total profit before taxation as a percentage of average net assets over the year and is not restated. Return on capital employed is not calculated for 2022 as it is not meaningful (n/m) as the average net assets over the year include Consumer Healthcare.

<table><tr><td>Balance sheet</td><td>2022</td><td>2021</td><td>2020</td></tr><tr><td>Non-current assets</td><td>39,377</td><td>60,429</td><td>60,184</td></tr><tr><td>Current assets</td><td>20,769</td><td>18,674</td><td>20,247</td></tr><tr><td>Total assets</td><td>60,146</td><td>79,103</td><td>80,431</td></tr><tr><td>Current liabilities</td><td>(22,810)</td><td>(23,670)</td><td>(22,148)</td></tr><tr><td>Non-current liabilities</td><td>(27,240)</td><td>(34,091)</td><td>(37,475)</td></tr><tr><td>Total liabilities</td><td>(50,050)</td><td>(57,761)</td><td>(59,623)</td></tr><tr><td>Net assets</td><td>10,096</td><td>21,342</td><td>20,808</td></tr><tr><td>Shareholders&#x27; equity</td><td>10,598</td><td>15,055</td><td>14,587</td></tr><tr><td>Non-controlling interests</td><td>(502)</td><td>6,287</td><td>6,221</td></tr><tr><td>Total equity</td><td>10,096</td><td>21,342</td><td>20,808</td></tr><tr><td>Number of employees</td><td>2022</td><td>2021 \( ^{(1)} \)</td><td>2020 \( ^{(1)} \)</td></tr><tr><td>US</td><td>11,946</td><td>14,289</td><td>15,706</td></tr><tr><td>Europe</td><td>31,800</td><td>38,809</td><td>40,711</td></tr><tr><td>International</td><td>25,654</td><td>36,998</td><td>37,649</td></tr><tr><td></td><td>69,400</td><td>90,096</td><td>94,066</td></tr><tr><td>Manufacturing</td><td>23,292</td><td>32,141</td><td>33,848</td></tr><tr><td>Selling</td><td>26,310</td><td>34,846</td><td>36,391</td></tr><tr><td>Administration</td><td>7,605</td><td>11,014</td><td>11,730</td></tr><tr><td>Research and development</td><td>12,193</td><td>12,095</td><td>12,097</td></tr><tr><td></td><td>69,400</td><td>90,096</td><td>94,066</td></tr></table>

The geographic distribution of employees in the table above is based on the location of GSK’s subsidiary companies. The number of employees is the number of permanent employed staff at the end of the financial period. It excludes those employees who are employed and managed by GSK on a contract basis.

(1) The employee numbers have not been restated for the purposes of the Consumer Healthcare demerger.



## Pipeline, products and competition

## Pharmaceuticals and Vaccines product development pipeline

<table><tr><td>Key</td><td>†</td><td>In-license or other alliance relationship with third party</td><td>EUA</td><td>Emergency Use Authorisation</td></tr><tr><td></td><td>^</td><td>ViiV Healthcare, a global specialist HIV company with GSK, Pfizer, Inc. and Shionogi Limited as shareholders, is responsible for developing and delivering HIV medicines</td><td>Phase I</td><td>Evaluation of clinical pharmacology, usually conducted in volunteers</td></tr><tr><td></td><td>BLA</td><td>Biological Licence Application</td><td>Phase II</td><td>Determination of dose and initial evaluation of efficacy, conducted in a small number of patients</td></tr><tr><td></td><td>MAA</td><td>Marketing Authorisation Application (Europe)</td><td>Phase III</td><td>Large comparative study (compound versus placebo and/or established treatment) in patients to establish clinical benefit and safety</td></tr><tr><td></td><td>NDA</td><td>New Drug Application (US)</td><td></td><td></td></tr><tr><td></td><td>A</td><td>Approved</td><td></td><td></td></tr><tr><td></td><td>S</td><td>Submitted</td><td></td><td></td></tr></table>

MAA and NDA/BLA regulatory review milestones shown in the table below are those that have been achieved. Future filing dates are not included in this list.

<table><tr><td>Compound</td><td>Mechanism of Action/Vaccine Type</td><td>Indication</td><td>Phase</td><td>Achieved regulatory review milestones</td></tr><tr><td>Oncology</td><td></td><td></td><td></td><td></td></tr><tr><td>mometolinitb¹</td><td>JAK1, JAK2 and ACVRI inhibitor</td><td>myelofibrosis</td><td>Registration</td><td>S:Nov22 S:Jun22</td></tr><tr><td>Jemperli (dostarlimab)†</td><td>Anti-Programmed Cell Death protein 1 receptor (PD-1) antibody</td><td>1L endometrial cancer1L endometrial cancer combination with Zejula (niraparib)Non-small cell lung cancer¹</td><td>IIIIII</td><td></td></tr><tr><td>Zejula (niraparib)†</td><td>Poly (ADP-ribose) polymerase (PARP) 1/2 inhibitor</td><td>1L maintenance ovarian cancer combination with Jemperli (dostarlimab)1L maintenance non small cell lung cancer (NSCLC) combination with pembrolizumab Pre-metastatic, select biomarker population Breast Cancer</td><td>IIIIII</td><td></td></tr><tr><td>Blenrep (belantamab mafodotin)†</td><td>ADC targeting B-cell maturation antigen</td><td>2L+ multiple myeloma combination with Pomalyst and dexamethasone2L+ multiple myeloma combination with Velcade and dexamethasoneMultiple myeloma in combination with anti-cancer treatments (platform study)1L multiple myeloma combination with Velcade, I Revlimid and dexamethasone</td><td>IIIIII</td><td></td></tr><tr><td>cobolimab†</td><td>Anti-T-cell immunoglobulin and mucin domain-3 (TIM-3) antibody</td><td>Non-small cell lung cancer combination with Jemperli (dostarlimab) and docetaxel</td><td>III</td><td></td></tr><tr><td>4428859 (EOS884448)†</td><td>anti-TIGIT</td><td>Non-small cell lung cancer combination with Jemperli (platform study)</td><td>II</td><td></td></tr><tr><td>4074386†</td><td>Anti-lymphocyte activation gene-3 (LAG-3) antibody</td><td>Cancer</td><td>I</td><td></td></tr><tr><td>4381562†</td><td>anti-PVRIG</td><td>Cancer</td><td>I</td><td></td></tr><tr><td>3745417</td><td>STING cytosolic DNA pathway agonist</td><td>Advanced solid tumorsMyeloid malignancies</td><td>I</td><td></td></tr><tr><td>6097608†</td><td>anti-CD96</td><td>Cancer</td><td>I</td><td></td></tr><tr><td>XMT-2056² (wholly owned by Mersana Therapeutics)</td><td>STING agonist ADC</td><td>Cancer</td><td>I</td><td></td></tr><tr><td>HIV^</td><td></td><td></td><td></td><td></td></tr><tr><td>Apretude (cabotegravir)</td><td>HIV integrase strand transfer inhibitor (long-acting)</td><td>HIV pre-exposure prophylaxisHIV infection (400 mg/ml formulation)</td><td>Approved</td><td>S:Jun22 A: Dec21</td></tr><tr><td>3640254</td><td>HIV maturation inhibitor</td><td>HIV infection</td><td>II³</td><td></td></tr><tr><td>3810109†</td><td>HIV broadly neutralising antibody</td><td>HIV infection</td><td>II</td><td></td></tr><tr><td>3739937</td><td>HIV maturation inhibitor</td><td>HIV infection</td><td>I</td><td></td></tr><tr><td>4004280</td><td>HIV capsid protein inhibitor</td><td>HIV infection</td><td>I</td><td></td></tr><tr><td>4011499</td><td>HIV capsid protein inhibitor</td><td>HIV infection</td><td>I</td><td></td></tr><tr><td>4524184†</td><td>HIV integrase inhibitor</td><td>HIV infection</td><td>I</td><td></td></tr></table>

Brand names appearing in italics are trade marks owned by or licensed to the GSK group of companies.

Footnotes

1 non-registrational

2 GSK has an exclusive global license option to co-develop and commercialize the candidate

3 will not progress to Phase 3



## Pipelines, products and competition continued

Pharmaceuticals and Vaccines product development pipeline continued

<table><tr><td rowspan="2">Compound</td><td rowspan="2">Mechanism of Action/Vaccine Type</td><td rowspan="2">Indication</td><td rowspan="2">Phase</td><td colspan="2">Achieved regulatory review milestones</td></tr><tr><td>MAA</td><td>NDA/BLA</td></tr><tr><td colspan="6">Infectious Diseases</td></tr><tr><td>Xevudy (sotrovimab)†</td><td>Anti-spike protein antibody</td><td>COVID-19</td><td>Approved</td><td>A:Dec21</td><td>EUA: May21‡</td></tr><tr><td>Priorix (MMR vaccine)</td><td>Live attenuated</td><td>Measles, mumps, rubella prophylaxis (US)</td><td>Approved</td><td></td><td>A: Jun22</td></tr><tr><td>Menveo vaccine</td><td>Conjugated-liquid formulation</td><td>Meningococcal A, C, W, Y disease prophylaxis in adolescents</td><td>Approved</td><td></td><td>A: Oct22</td></tr><tr><td>Rotarix vaccine</td><td>Live attenuated, PCV (Porcine circovirus) free</td><td>Rotavirus prophylaxis (US)</td><td>Approved</td><td></td><td>A: Nov22</td></tr><tr><td>VidPrevtyn Beta COVID-19 vaccine (Sanofi)‡</td><td>Recombinant protein-adjuvanted vaccine</td><td>COVID-19</td><td>Approved</td><td>A: Nov22</td><td></td></tr><tr><td>3844766 (RSV vaccine)†</td><td>Recombinant protein - adjuvanted vaccine</td><td>Respiratory syncytial virus prophylaxis in older adult population 60 years of age and older Respiratory syncytial virus prophylaxis in older adult population 50-59 years of age</td><td>Registration</td><td>S:Oct22</td><td>S:Oct22</td></tr><tr><td>SKYCovione (SK Bioscience)†‡</td><td>Recombinant protein nanoparticle-adjuvanted vaccine</td><td>COVID-19</td><td></td><td>Registration‡</td><td>S:Jul22</td></tr><tr><td>gepotidacin†</td><td>Triazaacenaphthylene bacterial type II topoisomerase inhibitor</td><td>Uncomplicated urinary tract infection (uUTI) Urogenital gonorrhea (GC)</td><td>III</td><td></td><td>III</td></tr><tr><td>bepiroversin †</td><td>HBV antisense</td><td>Hepatitis B Hepatitis B sequential therapy with Pegylated Interferon</td><td>III</td><td></td><td>III</td></tr><tr><td>Bexsero vaccine</td><td>Recombinant protein vaccine</td><td>Meningococcal B disease prophylaxis 2 months of age and older (US)</td><td>III</td><td></td><td></td></tr><tr><td>3536819 (Men ABCWY vaccine)</td><td>Recombinant protein - conjugated vaccine</td><td>Meningococcal A, B, C, W, Y disease prophylaxis in adolescents</td><td>III</td><td></td><td></td></tr><tr><td>tebipenem pivoxil†</td><td>Antibacterial carbapenem</td><td>Complicated urinary tract infection (UTI)†</td><td>III</td><td></td><td></td></tr><tr><td>3036656†</td><td>Leucyl t-RNA synthetase inhibitor</td><td>Tuberculosis</td><td>II</td><td></td><td></td></tr><tr><td>BVL-GSK098†</td><td>Ethionamide booster</td><td>Tuberculosis</td><td>II</td><td></td><td></td></tr><tr><td>VIR-2482‡</td><td>Neutralizing monoclonal antibody</td><td>Influenza</td><td>II</td><td></td><td></td></tr><tr><td>3437949† (Malaria fractional dose)</td><td>Recombinant protein - adjuvanted vaccine</td><td>Malaria prophylaxis (Plasmodium falciparum)</td><td>II</td><td></td><td></td></tr><tr><td>3536852†</td><td>Generalized Modules for Membrane Antigens (GMMA) vaccine</td><td>Shigella diarrhea prophylaxis</td><td>II</td><td></td><td></td></tr><tr><td>3528869† (Therapeutic HBV)</td><td>Prime-boost with viral vector co- or sequentially administrated with adjuvanted recombinant proteins</td><td>Treatment of chronic Hepatitis B infections - aims at functional cure by controlling and resolving the clinical sequelae of the infection and reducing the need for further treatment</td><td>II</td><td></td><td></td></tr><tr><td>4023393 (Men ABCWY, 2nd Gen) vaccine</td><td>Recombinant protein - conjugated vaccine</td><td>Meningococcal A, B, C, W, Y disease prophylaxis in adolescents and children 6 weeks and older</td><td>II</td><td></td><td></td></tr><tr><td>4178116 (Varicella new strain)</td><td>Live attenuated vaccine</td><td>Active immunization for the prevention of varicella in individuals from 12 months of age and older</td><td>II</td><td></td><td></td></tr><tr><td>sanfetrinem cilexetil†</td><td>Serine beta lactamase inhibitor</td><td>Tuberculosis</td><td>II</td><td></td><td></td></tr><tr><td>4106647†</td><td>Recombinant protein-adjuvanted vaccine</td><td>Active immunization of girls and women, boys and men (9-45 years), for the prevention of cancer, genital warts and precancerous or dysplastic lesions (girls, boys AIN only) caused by Human papillomavirus (HPV)</td><td>II</td><td></td><td></td></tr></table>

Brand names appearing in italics are trade marks owned by or licensed to the GSK group of companies.

Footnotes

4 As of Apr22, sotrovimab is no longer authorized to treat COVID-19 in U.S. due to increases in the proportion of COVID-19 cases caused by the Omicron BA.2 sub-variant

5 GSK is contributing pandemic adjuvant to COVID-19 vaccines collaborations

6 Approved in South Korea (Jun22)

7 Phase 2 or 3 study start expected in 2023

8 GSK has exclusive option to co-develop post Phase 2



## Pipelines, products and competition continued

Pharmaceuticals and Vaccines product development pipeline continued

<table><tr><td rowspan="2">Compound</td><td rowspan="2">Mechanism of Action/Vaccine Type</td><td rowspan="2">Indication</td><td rowspan="2">Phase</td><td colspan="2">Achieved regulatory review milestones</td></tr><tr><td>MAA</td><td>NDA/BLA</td></tr><tr><td colspan="6">Infectious Diseases continued</td></tr><tr><td>4388067 (CHBV ASO combo)†</td><td>Targeted Immunotherapy (viral vector; adjuvanted recombinant proteins) &amp; Direct Acting Antiviral (GSK&#x27;s bepiroviren)</td><td>Treatment of chronic Hepatitis B virus infection in individuals &gt;18 years without decompensated cirrhosis</td><td>II</td><td></td><td></td></tr><tr><td>5101955†</td><td>Vaccine using Multiple Antigen Presenting System (MAPS) platform</td><td>Prevention of pneumonia and invasive pneumococcal disease caused by the Streptococcus pneumoniae 24 serotypes included in the vaccine in children aged 6 weeks - 17 years.</td><td>II</td><td></td><td></td></tr><tr><td>5101956†</td><td>Vaccine using Multiple Antigen Presenting System (MAPS) platform</td><td>Prevention of pneumonia and invasive pneumococcal disease caused by the Streptococcus pneumoniae 24 serotypes included in the vaccine in adults aged 18 years and older</td><td>II</td><td></td><td></td></tr><tr><td>4406371 (MMRV new strain)</td><td>Live attenuated vaccine</td><td>Active immunization for the prevention of measles, mumps, rubella, and varicella in children 12 months through 12 years of age</td><td>II</td><td></td><td></td></tr><tr><td>3882347†</td><td>FimH antagonist</td><td>Uncomplicated urinary tract infection (uUTI)</td><td>I</td><td></td><td></td></tr><tr><td>3186899†9</td><td>CRK-12 inhibitor</td><td>Visceral leishmaniasis</td><td>I</td><td></td><td></td></tr><tr><td>3494245†</td><td>Proteasome inhibitor</td><td>Visceral leishmaniasis</td><td>I</td><td></td><td></td></tr><tr><td>2556286†</td><td>Mtb cholesterol dependent inhibitor</td><td>Tuberculosis</td><td>I</td><td></td><td></td></tr><tr><td>4182137 (VIR-7832)†</td><td>Anti-spike protein antibody</td><td>COVID-19</td><td>I</td><td></td><td></td></tr><tr><td>3923868</td><td>PI4K beta inhibitor</td><td>Viral COPD exacerbations</td><td>I</td><td></td><td></td></tr><tr><td>2904545†</td><td>Recombinant protein - adjuvanted vaccine</td><td>Active immunization for the prevention of the primary C. difficile diseases and for prevention of recurrences</td><td>I</td><td></td><td></td></tr><tr><td>4429016†</td><td>Recombinant protein - bioconjugated - adjuvanted vaccine</td><td>Klebsiella pneumoniae prophylaxis</td><td>I</td><td></td><td></td></tr><tr><td>3993129</td><td>Recombinant subunit - adjuvanted vaccine</td><td>Cytomegalovirus (CMV) infection prophylaxis in females 16-49 years of age</td><td>I</td><td></td><td></td></tr><tr><td>4382276†</td><td>mRNA vaccine</td><td>Active immunization for the prevention of disease caused by influenza viruses in adults 18 years and older</td><td>I</td><td></td><td></td></tr><tr><td>4396687†</td><td>mRNA vaccine</td><td>Active immunization to prevent COVID-19 disease caused by SARS-CoV-2 virus in individuals 12 years and older</td><td>I</td><td></td><td></td></tr><tr><td>3943104† (Therapeutic HSV)</td><td>Recombinant protein-adjuvanted</td><td>Active immunization to suppress recurrence of Genital Herpes in adults aged 18 years and older.</td><td>I</td><td></td><td></td></tr><tr><td>4077164†</td><td>Bivalent Generalized Modules for Membrane Antigens (GMMA) vaccine</td><td>Invasive non-typhoidal salmonella</td><td>I</td><td></td><td></td></tr><tr><td>4077164†</td><td>Bivalent Generalized Modules for Membrane Antigens (GMMA) vaccine and typhoid conjugate vaccine (TCV)</td><td>Invasive non-typhoidal salmonella and typhoid fever</td><td>I</td><td></td><td></td></tr><tr><td>3536867†</td><td>Bivalent Typhoid and Paratyphoid A conjugate</td><td>Salmonella typhoid and paratyphoid (A) enteric fever</td><td>I</td><td></td><td></td></tr><tr><td>3965193</td><td>PAPD5/PAPD7 inhibitor</td><td>Hepatitis B</td><td>I</td><td></td><td></td></tr><tr><td>5251738†</td><td>TLR8 agonist</td><td>Hepatitis B</td><td>I</td><td></td><td></td></tr><tr><td>3772701†</td><td>P falciparum whole cell inhibitor (pyrrolidine amides)</td><td>Malaria</td><td>I</td><td></td><td></td></tr><tr><td>4348413</td><td>Generalized Modules for Membrane Antigens (GMMA) vaccine</td><td>Active immunization to prevent gonorrhea in individuals age 16 years and older, regardless of previous gonorrhea infection history</td><td>I</td><td></td><td></td></tr></table>

Brand names appearing in italics are trade marks owned by or licensed to the GSK group of companies.

Footnotes

9 Transition activities underway to enable further progression by partner



## Pipelines, products and competition continued

Pharmaceuticals and Vaccines product development pipeline continued

<table><tr><td rowspan="2">Compound</td><td rowspan="2">Mechanism of Action/Vaccine Type</td><td rowspan="2">Indication</td><td rowspan="2">Phase</td><td colspan="2">Achieved regulatory review milestones</td></tr><tr><td>MAA</td><td>NDA/BLA</td></tr><tr><td colspan="6">Immunology and Respiratory</td></tr><tr><td>Nucala (mepolizumab)</td><td>Anti-IL5</td><td>COPD</td><td>III</td><td></td><td></td></tr><tr><td>depemokimab¹</td><td>Anti-IL5 (long-acting)</td><td>Asthma</td><td>III</td><td></td><td></td></tr><tr><td></td><td></td><td>Chronic rhinosinusitis with nasal polyps (CRSwNP)</td><td>III</td><td></td><td></td></tr><tr><td></td><td></td><td>Eosinophilic granulomatosis with polyangiitis (EGPA)</td><td>III</td><td></td><td></td></tr><tr><td></td><td></td><td>Hypereosinophilic syndrome (HES)</td><td>III</td><td></td><td></td></tr><tr><td>Iatozinemab¹</td><td>Anti-Sortilin monoclonal antibody</td><td>Frontotemporal Dementia (FTD) due to Heterozygous Mutations in the Progranulin Gene</td><td>III</td><td></td><td></td></tr><tr><td></td><td></td><td>Amyotrophic Lateral Sclerosis (ALS)</td><td>II</td><td></td><td></td></tr><tr><td></td><td></td><td>Frontotemporal Dementia (FTD) due to Mutations in the C9orf72 Gene</td><td>II</td><td></td><td></td></tr><tr><td>Benlysta (belimumab)</td><td>B lymphocyte stimulator monoclonal antibody</td><td>Systemic sclerosis associated interstitial lung disease⁵</td><td>II</td><td></td><td></td></tr><tr><td>3858279¹</td><td>Anti-CCL17</td><td>Osteoarthritis pain</td><td>I</td><td></td><td></td></tr><tr><td>4527226 (AL101)¹</td><td>Anti-sortilin monoclonal antibody</td><td>Neurodegenerative disease</td><td>I</td><td></td><td></td></tr><tr><td>1070806</td><td>Anti-IL18</td><td>Atopic dermatitis</td><td>I</td><td></td><td></td></tr><tr><td>3888130¹</td><td>Anti-IL7</td><td>Multiple sclerosis (MS)</td><td>I</td><td></td><td></td></tr><tr><td colspan="6">Opportunity Driven</td></tr><tr><td>Jesduvrog (daprodustat)</td><td>Prolyl hydroxylase inhibitor</td><td>Anaemia of chronic kidney disease</td><td>Approved</td><td>S.Feb22</td><td>A.Feb23</td></tr><tr><td>linearixibat</td><td>Ileal bile acid transporter (IBAT) inhibitor</td><td>Cholestatic pruritus in PBC (primary biliary cholangitis)</td><td>III</td><td></td><td></td></tr><tr><td>4532990¹</td><td>HSD17B13 silencer</td><td>Non-alcoholic steatohepatitis (NASH)⁷</td><td>II</td><td></td><td></td></tr><tr><td>4172239¹</td><td>DNMT1 inhibitor</td><td>Sickle cell disease¹⁰</td><td>I</td><td></td><td></td></tr></table>

Brand names appearing in italics are trade marks owned by or licensed to the GSK group of companies.

Footnotes

7 Phase 2 or 3 study start expected in 2023

10 Imminent study start



## Pharmaceutical products, competition and intellectual property

<table><tr><td>Products</td><td>Compounds</td><td>Indication(s)</td><td>Major competitor brands</td><td colspan="2">Patent expiry dates¹</td></tr><tr><td>Respiratory</td><td></td><td></td><td></td><td>US</td><td>EU</td></tr><tr><td>Anoro Ellipta</td><td>umeclidinium bromide/vilanterol trifenatate</td><td>COPD</td><td>Spiolto/Stiolto Respimat, Utibron/Ultibro Breezhaler, Duaklir Genuair Bevespi Aerosphere, Brimica Genuair</td><td>2027 (NCE) 2027-2030 (device)</td><td>2029 (NCE) 2022-2026 (device)</td></tr><tr><td>Avamys/Veramyst</td><td>fluticasone furoate</td><td>Allergic rhinitis</td><td>Dymista, Xhance, Nasonex, Fluticasone Gx</td><td>expired</td><td>expired</td></tr><tr><td>Relvar/Breo Ellipta</td><td>fluticasone furoate/vilanterol trifenatate</td><td>Asthma, COPD</td><td>Symbicort, Foster, Budesonide/Formoterol Gx Sirdupla, Dulera</td><td>2025 (NCE) 2027-2030 (device)</td><td>2027 (NCE) 2022-2026 (device)</td></tr><tr><td>Seretide/Advair</td><td>salmeterol xinafoate/fluticasone propionate</td><td>Asthma, COPD</td><td>Symbicort, Foster, Budesonide/Formoterol Gx Sirdupla, Dulera</td><td>expired (Diskus device) 2023-2026 (HFA-device)</td><td>expired (Diskus device) 2029 (HFA-device)</td></tr><tr><td>Trelegy Ellipta</td><td>fluticasone furoate/vilanterol trifenatate umeclidinium bromide</td><td>COPD, asthma</td><td>Trimbow pMDI/NEXThaler, Breztri Aerosphere, Trixeo Aerosphere, Enerzaire Breezhaler</td><td>2027 (NCE) 2027-2030 (device)</td><td>2029 (NCE) 2022-2026 (device)</td></tr><tr><td>Ventolin HFA</td><td>Salbutamol sulphate</td><td>Asthma, COPD</td><td>generic companies</td><td>2023-2026 (HFA-device)</td><td>expired (HFA-device)</td></tr><tr><td>Xevudy</td><td>sotrovimab</td><td>Early treatment of COVID-19</td><td>REGEN-COV, bamlanivimab/etesevimab, Evusheld</td><td>2041 (NBE)</td><td>NA</td></tr><tr><td colspan="6">Central nervous system</td></tr><tr><td>Lamictal</td><td>lamotrigine</td><td>Epilepsy, bipolar disorder</td><td>Vimpat, Trokendi XR, Inovelon, Keppra</td><td>expired</td><td>expired</td></tr><tr><td>Keppra</td><td>levetiracetam</td><td>Epilepsy</td><td>Briviact, Vimpat, Lamictal, Depakene, Depacon</td><td>NA</td><td>NA</td></tr><tr><td colspan="6">Cardiovascular and urogenital</td></tr><tr><td>Avodart &amp; Dvadart</td><td>dutasteride dutasteride + tamsulosin</td><td>Benign prostatic hyperplasia (BPH)</td><td>Generic products, Finasteride, Alpha Blockers</td><td>expired</td><td>expired</td></tr><tr><td colspan="6">Anti-bacterials</td></tr><tr><td>Augmentin</td><td>Amoxicillin trihydrate/potassium clavulanate</td><td>Common bacterial infections</td><td>Generic products (Clavam, Moxikind-CV, Enhancin, Curam, Calamox) Oral Cephalosporins - Cefuroxime axetil, Cefixime, Cefpodoxime, Cefdinir, Cephalexin Oral Macrolides - Azithromycin, Clarithromycin</td><td>NA</td><td>expired</td></tr></table>

1 Includes Supplementary Protection Certificates which were granted in multiple countries in EU (including the UK) and patent term extensions granted in the US.



## Pipelines, products and competition continued

Pharmaceutical products, competition and intellectual property continued

<table><tr><td>Products</td><td>Compounds</td><td>Indication(s)</td><td>Major competitor brands</td><td colspan="2">Patent expiry dates¹</td></tr><tr><td>Dermatology</td><td></td><td></td><td></td><td>US</td><td>EU</td></tr><tr><td>Dermovate, Betnovate, Cutivate, Eumovate</td><td>Clobetasol propionate, Betamethasone valerate, Fluticasone propionate, Clobetasone butyrate</td><td>Inflammatory skin conditions</td><td>Generic products, Other topical corticosteroids like Mometasone furoate, Methylprednisolone aceponate and Hydrocortisone.</td><td>Not marketed in US</td><td>Expired</td></tr><tr><td>Oncology</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Zejula</td><td>niraparib</td><td>ovarian cancer</td><td>Lynparza, Rubraca</td><td>2031 (NCE)</td><td>2028 (NCE)</td></tr><tr><td>Blenrep</td><td>belantamab mafodotin</td><td>relapsed/refractory multiple myeloma</td><td>Sarclisa, Xpovio</td><td>2032</td><td>2032</td></tr><tr><td>Jemperli</td><td>dostarlimab</td><td>dMMR recurrent or advanced endometrial cancer, solid tumours</td><td>Keytruda</td><td>2034 (NBE)</td><td>2034 (NBE)</td></tr><tr><td>Immuno-inflammation</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Benlysta, Benlysta (SC and IV)</td><td>belimumab</td><td>systemic lupus erythematosus, lupus nephritis</td><td>Lupkinis, Saphnelo</td><td>2025</td><td>2026</td></tr><tr><td>Jesduvrog, Duvrog</td><td>Daprodustat</td><td>anaemia of chronic kidney disease</td><td>Everenza (roxadustat), vadadustat</td><td>2027 (NCE)</td><td>2027 (NCE)</td></tr><tr><td>HIV</td><td></td><td></td><td></td><td></td><td></td></tr><tr><td>Apretude</td><td>Cabotegravir</td><td>HIV prevention</td><td>Descovy, Truvada</td><td>2026 (NCE)</td><td>2026 (NCE)</td></tr><tr><td>Cabenuva/Vocabria + Rekambys</td><td>Cabotegravir, rilpivirine</td><td>HIV/AIDS</td><td>Descovy, Genvoya, Odefsey, Biktarvy</td><td>2026 (NCE)</td><td>2026 (NCE)</td></tr><tr><td>Rukobia</td><td>Fostemsavir</td><td>HIV/AIDS</td><td>Trogarzo</td><td>2025 (NCE)</td><td>2025 (NCE)</td></tr><tr><td>Dovato</td><td>Dolutegravir, lamivudine</td><td>HIV/AIDS</td><td>Descovy, Genvoya, Odefsey, Biktarvy</td><td>2027 (NCE)</td><td>2029 (NCE)</td></tr><tr><td>Juluca</td><td>Dolutegravir, rilpivirine</td><td>HIV/AIDS</td><td>Descovy, Genvoya, Odefsey, Biktarvy</td><td>2027 (NCE)</td><td>2029 (NCE)</td></tr><tr><td>Triumeq</td><td>Dolutegravir, lamivudine and abacavir</td><td>HIV/AIDS</td><td>Descovy, Genvoya, Odefsey, Biktarvy</td><td>2027 (NCE)</td><td>2029 (NCE)</td></tr><tr><td>Tivicay</td><td>Dolutegravir</td><td>HIV/AIDS</td><td>Isentress, Prezista, Symtuza, Reyataz, Biktarvy</td><td>2027 (NCE)</td><td>2029 (NCE)</td></tr></table>

1 See Note 47 to the financial statements, 'Legal proceedings'.

2 Includes Supplementary Protection Certificates which were granted in multiple countries in EU (including the UK), and patent term extensions granted in the US.
a Related compounds/indications are measles, mumps and rubella vaccine/prophylaxis.

b Related compound is vincristine.



## Pipelines, products and competition continued

## Vaccine products, competition and intellectual property

<table><tr><td rowspan="2">Products</td><td rowspan="2">Compounds</td><td rowspan="2">Indication(s)</td><td rowspan="2">Major competitor brands</td><td colspan="2">Patent expiry dates²</td></tr><tr><td>US</td><td>EU</td></tr><tr><td>Bexsero</td><td>meningococcal group-B vaccine</td><td>Meningitis group B prevention</td><td>Trumenba</td><td>2027</td><td>2028</td></tr><tr><td>Boostrix</td><td>diphtheria, tetanus, acellular pertussis</td><td>diphtheria, tetanus, acellular Pertussis booster vaccination</td><td>Adacel</td><td>expired</td><td>expired</td></tr><tr><td>Infanrix Hexa/Pediatric</td><td>diphtheria, tetanus, pertussis, polio, hepatitis B, Haemophilus influenzae type B (EU)</td><td>Prophylaxis against diphtheria, tetanus, pertussis, polio, hepatitis B, Haemophilus influenzae type B (EU)</td><td>Pentacel, Pediacel, Pentaxim, Pentavac, Hexaxim, Hexyon Vaxelis</td><td>expired</td><td>expired</td></tr><tr><td>Cervarix</td><td>HPV 16 &amp; 18 virus like particles (VLPs), AS04 adjuvant (MPL + aluminium hydroxide)</td><td>human papilloma virus type 16 and 18</td><td>Gardasil (Silgard)</td><td>2028</td><td>expired</td></tr><tr><td>Fluarix Tetra</td><td>split inactivated influenza antigens (2 virus subtypes A and 2 subtype B)</td><td>seasonal influenza prophylaxis</td><td>Intenza, Fluminist QIV, Vaxigrip QIV, Fluzone QIV, Fluzone High Dose</td><td>expired</td><td>expired</td></tr><tr><td>FluLaval</td><td>split inactivated influenza antigens (2 virus subtypes A and 2 subtype B)</td><td>seasonal influenza prophylaxis</td><td>Vaxigrip, Mutagrip, Fluzone, Influvac, Aggripal, Fluid, Intenza, Fluminist</td><td>expired</td><td>expired</td></tr><tr><td>Menveo</td><td>meningococcal group A, C, W-135 and Y conjugale vaccine</td><td>Meningitis group A, C, W-135 and Y prophylaxis</td><td>Nimenrix, Menactra</td><td>2025</td><td>2025</td></tr><tr><td>Priorix, Priorix Tetra®</td><td>live attenuated measles, mumps, rubella and varicella vaccine</td><td>measles, mumps, rubella and chickenpox prophylaxis</td><td>MMR II (M-M-RVaxPro)</td><td>expired</td><td>expired</td></tr><tr><td>Varilrix®</td><td>human rotavirus RIX4414 strain</td><td>Rotavirus prophylaxis</td><td>Proquad, Varivax</td><td></td><td></td></tr><tr><td>Synflorix</td><td>conjugated pneumococcal polysaccharide</td><td>Prophylaxis against invasive disease, pneumonia, acute otitis media</td><td>Prevenar (Prevnar)</td><td>NA</td><td>2026</td></tr><tr><td>Shingrix</td><td>zoster vaccine recombinant, adjuvanted</td><td>herpes zoster (shingles)</td><td>Zostavax</td><td>2029</td><td>2031</td></tr></table>

1 See Note 47 to the financial statements, 'Legal proceedings'.

2 Includes Supplementary Protection Certificates which were granted in multiple countries in EU (including the UK), and patent term extensions granted in the US.
a Related compounds/indications are measles, mumps and rubella vaccine/prophylaxis.

b Related compound is varicella vaccine.



# Principal risks and uncertainties

We outline below the principal risks and uncertainties relevant to GSK’s business, financial condition and operations that may affect our performance and ability to achieve our objectives. These are the risks that we believe could cause our actual results to differ materially from expected and historical results.

Operating in the biopharmaceutical sector carries various inherent risks and uncertainties that may affect our business.

We must comply with a broad range of laws and regulations which apply to the research and development, manufacturing, testing, approval, distribution, sales, and marketing of pharmaceutical and vaccine products. These affect the cost of product development, the time required to reach the market and the likelihood of doing so successfully on an uninterrupted basis.

As rules and regulations change, government interpretation evolves, and our business activities develop, the nature of a particular risk may also alter. Changes to regulatory regimes may be substantial. Any alteration in, and failure to comply with, applicable laws and regulations could materially and adversely affect our financial results.

Similarly, our global business exposes us to litigation and government investigations, including product liability litigation, patent and antitrust litigation and sales and marketing litigation. Litigation and government investigations, and the related provisions we may make for unfavourable outcomes and increases in related costs such as insurance premiums, could also materially and adversely affect our financial results. More detail on the status and various uncertainties in our significant unresolved disputes and potential litigation is set out in Note 47, 'Legal proceedings.'

More details regarding our risk management framework and how we identify our principal risks can be found on pages 51 to 54 and incorporated herein. Other risks, not at the level of principal risk, and opportunities, related to Environmental, Social, and Governance (ESG), including environmental sustainability and climate change, are managed through our six focus areas, as described in our ESG Performance Report. Additional information on climate related risk management is in our climate related financial disclosure. See pages 55 to 62.

UK regulations require a description of principal risks and uncertainties and explanation of how these are being managed or mitigated. Below is a description of each of our principal risks together with a summary of how we manage each risk across our businesses. They are not listed in order of significance and are consistent with the principal risks detailed on pages 53 to 54. In July 2022, the Board agreed that Separation was no longer a principal risk following the successful demerger and analysis of any residual risk.

## Patient safety

## Risk definition

The risk that GSK, including our third parties, potentially fails to appropriately collect, review, follow up, or report human safety information, including adverse events, from all potential sources or that GSK potentially fails to act on any relevant findings in a timely manner.

## Risk impact

GSK will not tolerate an unfavourable benefit-to-risk profile for patients who use our products. As the most important consequence of ineffective pharmacovigilance is the potential for harm to patients, we maintain robust processes for managing human safety information, conducting timely safety signal detection, and ensuring appropriate measures are in place to manage risks to patients. GSK also intends to fully comply with pharmacovigilance and other relevant regulations worldwide. Non-compliance could result in inspection findings, regulatory scrutiny, civil or criminal sanctions and either temporary or permanent loss of product marketing authorisation. We regularly review and respond to all patient safety risks to limit the potential for reputational damage, loss of trust by patients and healthcare providers, product-related litigation, and loss of shareholder confidence.

## Context

We are fully accountable for safeguarding patients; our failure to do so effectively could result most importantly in harm to patients, as well as reputational damage and/or product liability litigation. We conduct internal safety surveillance and rely on access to safety information from external sources. Information on the safety and efficacy of our products in humans is collected during clinical development, with more comprehensive information incorporated from real-world use once our products are marketed. There are examples of regulatory agencies using real-world evidence from sources which may not be accessible to the industry to supplement and validate the evidence we use to support the safety and efficacy of our products. There is a potential emerging risk that technology companies or other data custodians may similarly draw and communicate conclusions about the safety of our products based on digital health data collected through their platforms that is inaccessible by either the industry or regulatory agencies.



## Principal risks and uncertainties continued

## Patient safety continued

Our licence to operate depends on our compliance with regulatory requirements worldwide, not only those directly related to patient safety but extending to privacy and information security regulations as well. Regulatory compliance depends on appropriate identification and management of human safety information by all employees and third parties acting on our behalf. We are pursuing innovative solutions to enhance our ability to perform pharmacovigilance, including Artificial Intelligence and Machine Learning technology to augment our capacity to manage increasing volumes of adverse event reports from varied sources, and advancing technical solutions for delivering safety information and risk minimisation measures to patients and health care providers.

The COVID-19 pandemic has had an impact on pharmacovigilance activities by increasing public focus on safety and efficacy of medicines and vaccines, highlighting the importance of robust business continuity planning for uninterrupted safety oversight and regulatory compliance (including the ability to accommodate remote regulatory inspections), and accelerating automation to manage increasing volumes of adverse events.

## Mitigating activities

Our Chief Medical Officer is accountable for the Patient Safety enterprise risk and human safety matters, in collaboration with the Head of Global Safety. A cross-enterprise safety governance board oversees implementation of our control framework, including risk management. Our Global Safety Board ensures that we address human safety proactively throughout a product’s lifecycle. Our global policy on management of human safety information requires that all employees immediately report issues relating to the safety of our products.
Our Third Party Oversight framework ensures that third parties who may encounter human safety information are identified and trained appropriately. We manage safety information for all products and from all sources in compliance with global regulations. This information allows us to detect safety signals for our products and take timely action on information that changes a product’s risk/benefit profile.

Any actions are discussed beforehand with regulatory authorities, and can include updating the prescribing information, communicating with healthcare providers, restricting product prescribing/availability to help assure safe use, and carrying out further clinical trials. In certain cases, it may be appropriate to stop clinical trials or to withdraw a product (or a specific batch) from the market.

In 2022, we completed the simplification and optimisation of our core patient safety processes, which we expect to improve cross-functional stakeholder engagement in safety activities across GSK. We began automated end-to-end processing of individual case safety reports to deliver better case quality and consistency as well as enhanced efficiency. Our Pharmacovigilance Operations model expanded to ensure connectivity between central and local safety teams. We have created resources for R&D leaders that enable them to advocate the need for industry access to safety data from all sources as the best way to safeguard patients. In 2023, we will transition from a two-vendor to a single-vendor model for key operational activities which will improve efficiency and reduce the risk of regulatory non-compliance. We will also expand our Global Safety team to include additional expertise to optimise our strategy and approach to product-related risk mitigation/minimisation.

## Product quality

## Risk definition

The risk that GSK or our third parties potentially fail to ensure appropriate controls and governance of quality for development and commercial products; compliance with industry practices and regulations in manufacturing and distribution activities; and terms of GSK product licenses and supporting regulatory activities.

## Risk impact

A failure to ensure product quality could have far-reaching implications for patient safety, cause product launch delays, drug shortages or product recalls, and have regulatory, legal, and financial consequences. These could materially and adversely affect GSK’s reputation and financial results.

## Context

The external environment for product quality remains challenging, with increased cyber-attacks and data breaches across the industry. Cyber-attacks remain a key risk to the integrity of product quality data and its audit trail. We met our commitments for the 2021 European Medicines Agency (EMA) requirements for licensing of Medical Devices. We continue to plan for the deployment of the New Annex 1 guidance for the manufacture of Sterile Medicinal products which was published in September 2022 and sets an expectation for compliance by August 2023. We are actively managing this implementation in the context of global equipment and component supply chain constraints effecting the industry. We are increasingly applying advanced digital technologies and insights to drive scientific excellence to enhance the development, manufacture and testing of our products. For example, we use new electronic documentation systems and advanced laboratory information management tools. Our quality organisations are aligned to make sure quality procedures and governance can facilitate the new company strategy. Pre-pandemic levels of on-site inspections have resumed, and we continue to take steps to ensure our inspection readiness.



## Principal risks and uncertainties continued

## Product quality continued

## Mitigating activities

We align an extensive global network of quality and compliance professionals, from site-level to senior management within each business unit to provide oversight and assist with the delivery of quality performance and operational compliance. We deliver this management oversight through a hierarchy of quality councils, an independent chief product quality officer and a global product quality office that oversees product quality risk across the company. We have developed and implemented a single quality management system that defines the quality standards and systems for our businesses associated with the development and commercialisation of our vaccines, specialty, and general medicines. A consolidation of regulatory requirements from markets across the world augments this system, which means it meets external expectations for product quality in the markets we supply. Our system is based on the internationally recognised principles from the ICH Q10 pharmaceutical quality system framework.

We routinely update our quality management system (QMS), so it keeps pace with the evolving external regulatory environment and new scientific understanding of our products and processes. We have also made our policies and procedures simpler to understand and implement and adopted innovative tools to make them more user-friendly. We regularly train staff in regulatory expectations and learnings from inspections and existing procedures so they can maintain Current Good Manufacturing Practice standards.
We have implemented a risk-based approach to assessing and managing third party suppliers that provide materials used in our finished products. We expect contract manufacturers that make our products to comply with GSK standards and regularly conduct audits to provide us with assurance that they do. We have product incident committee processes in place to investigate product issues and make recommendations on remediation activities including, where necessary, the recall of medicines and vaccines to protect our patients and the public.

Our established complaint process ensures we respond appropriately to product quality issues raised by patients. Independent functions review and triage allegations of noncompliance or misconduct received through formal and informal 'Speak Up' channels. Global disciplinary and enforcement procedures apply to any breaches of our standards, and are initiated, as appropriate, following investigations. We use key risk indicators to support risk management activities and provide GSK's Leadership Team and Risk Oversight and Compliance Council with an integrated assessment of product quality performance. We have completed all product assessments for the presence of nitrosamines and reported as necessary to all Health Authorities. We have also developed mitigation plans which will be executed throughout 2023 per the regulatory requirements. We are actively working with industry bodies and the European Regulatory Authorities to complete the safety evaluation of Titanium Dioxide in Medicines as well as identifying any potential substitutes.

## Financial controls and reporting

## Risk definition

The risk that GSK fails to comply with current tax laws, fails to report accurate financial information in compliance with accounting standards and applicable legislation, or incurs significant losses due to treasury activities.

## Risk impact

Non-compliance with existing or new financial or new ESG reporting and disclosure requirements, or changes to the recognition of income and expenses, could expose GSK to litigation and regulatory action and could materially and adversely affect our financial results. Failure to comply with changes in the substance or application of the laws governing transfer pricing, dividends, tax credits and intellectual property could also materially and adversely affect our financial results. Failure to comply with applicable sanctions laws and regulations could result in GSK being investigated by relevant government agencies and authorities and/or in legal proceedings against us. Government investigations and litigation, can be unpredictable and regardless of their outcome, may be costly, require significant management attention, and damage our reputation. Inconsistent application of treasury policies, transactional or settlement errors, or counterparty defaults could lead to significant losses.

## Context

We are required by the laws of various jurisdictions to publicly disclose our financial results and events that could materially affect the Group’s financial results. Regulators routinely review the financial statements of listed companies for compliance with new, revised, or existing accounting and regulatory requirements. We believe that we comply with the appropriate regulatory requirements concerning our financial statements and the disclosure of material information, including any transactions relating to business restructuring such as acquisitions and divestitures. However, should we be subject to an investigation into potential non-compliance with accounting and disclosure requirements, this could lead to restatements of previously reported results and significant penalties.

Our Treasury group deals daily in high value transactions, mostly foreign exchange, and cash management transactions. These transactions involve market volatility and counterparty risk. The Group’s effective tax rate reflects the locations of our activities and the value they generate, which determine the jurisdictions in which profits arise and the applicable tax rates.



## Principal risks and uncertainties continued

## Financial controls and reporting continued

These may be higher or lower than the UK statutory rate and may reflect regimes that encourage innovation and investment in R&D by providing tax incentives which, if changed, could affect GSK's tax rate. In addition, the worldwide nature of our operations means that our cross-border supply routes, necessary to ensure supplies of medicines and vaccines, can result in conflicting claims from tax authorities as to the profits to be taxed in individual countries. This can lead to double taxation, with profits taxed in more than one country. The complexity of tax regulations also means that we may occasionally disagree with tax authorities on the technical interpretation of a particular area of tax law. The tax charge included in our financial statements is our best estimate of tax liability pending any audits by tax authorities. We expect there to be a continued focus on tax reform, driven by initiatives by the OECD and the EC to address the tax challenges arising from digitalisation of the economy. Together with domestic initiatives around the world, these may result in significant changes to established tax principles and an increase in tax authority disputes. Regardless of their merit or outcomes, these may be costly, divert management attention and adversely impact our reputation and relationship with key stakeholders. Laws, regulations, orders and other measures restrict dealings with certain countries, governments, government officials, entities, individuals, use of financial institutions and movement of funds. Circumvention of sanctions and export controls can be a criminal offence and GSK seeks to comply with its sanctions obligations. While we believe the Group complies with all applicable sanctions in all material respects, such laws are complex and continue to evolve rapidly.

## Mitigating activities

We keep up to date with the latest developments in financial reporting requirements by reviewing updates from regulators, working with our external auditor and legal advisors and performing and responding to emerging risks. Financial results are reviewed and approved by regional management, before being reviewed by GSK's Group Financial Controller and Chief Financial Officer (CFO). This allows our Financial Controller and CFO to assess the evolution of the business over time, and to evaluate its performance to plan. Significant judgements are reviewed and confirmed by senior management. We integrate technical or organisational transformation, newly acquired activities and external risks into our risk assessments and apply appropriate controls and reviews. We maintain a control environment designed to identify material errors in financial reporting and disclosure. We have a standardised global financial reporting operating model.

The design and operating effectiveness of key financial reporting controls are regularly reviewed by management and tested by external third parties. The few locations which are not on the standard model apply a minimum standard set of controls which are reviewed by management and monitored independently. This gives us assurance that controls over key financial reporting and disclosure processes are operating effectively. Our Global Finance Risk Management and Controls (FRMC) group provides extra support during significant transformations, such as system deployment or management/structural reorganisations. We add operational resources and adapt programme timelines to ensure processes and controls are maintained during significant changes.
The Disclosure Committee, reporting to the Board, reviews GSK’s quarterly results and annual report. Throughout the year, in consultation with its legal advisors, the Disclosure Committee also determines whether it is necessary to disclose publicly information about the Group through stock exchange announcements. The Treasury Management Group meets regularly to ensure that liquidity, interest rate, counterparty, foreign currency transaction and foreign currency translation risks are all managed in line with the prudent approach detailed in the risk strategies and policies adopted by our Board.

Counterparty exposure is subject to defined limits approved by the Board for both credit rating and individual counterparties. The Middle Office within Treasury monitor the management of counterparty risk in line with agreed policy with oversight from a corporate compliance officer, operating independently of Treasury. Further details on mitigation of Treasury risks can be found on pages 246 to 248. We manage tax risk through robust internal policies, processes, training, and compliance programmes.

We maintain open and constructive relationships with tax authorities worldwide. We monitor government debate on tax policy in our key jurisdictions, so that we can understand any potential future changes in tax law and share an informed point of view. Where relevant, we provide pragmatic and constructive business input to tax policy makers, either directly or through industry trade bodies. This includes advocating reform to support economic growth and job creation, as well as the needs of our patients and other key stakeholders. Our tax affairs are managed on a global basis by a team of tax professionals, led by the Global Head of Tax, who work closely with the business on a day-to-day basis. The Global Tax team is suitably qualified for the roles they perform, and we support their training needs so they can provide up to date technical advice in line with their responsibilities. We submit tax returns according to statutory time limits and engage proactively with tax authorities to ensure our tax affairs are current, entering into continuous audit programmes and advance pricing agreements where appropriate. These arrangements provide long-term certainty for both tax authorities and GSK over the tax treatment of our business, based on full disclosure of all relevant facts. We seek to resolve any differences of interpretation in tax legislation with tax authorities in a cooperative manner. In exceptional cases, we may have to resolve disputes through formal proceedings. GSK is committed to complying with all applicable sanctions, laws and regulations, and has deployed a programme to enable management of sanctions risk. The programme, jointly led by GSK Finance and Legal & Compliance, is made up of various systems and controls including, but not limited to, policies and procedures, training and awareness, screening, monitoring and risk reporting.



## Anti-bribery and corruption (ABAC)

## Risk definition

The risk that GSK or our third parties potentially fail to comply with applicable laws, regulations, or internal requirements and to ensure appropriate controls and governance over bribery and corruption in business activities.

## Risk impact

Failure to mitigate this risk could expose GSK and associated persons to governmental investigation, regulatory action, and civil and criminal liability. It may compromise GSK’s ability to supply its products under certain government contracts. In addition, failure to prevent bribery or corruption could have substantial implications for GSK’s reputation and the credibility of senior leaders. It might erode investor confidence in our governance, risk management and future performance, and have a consequential negative impact on share performance. It could also lead to the imposition of significant financial penalties and the imposition of additional reporting obligations.

## Context

There continues to be a strong enforcement appetite for foreign bribery investigations and prosecutions, with a particular focus on the conduct of multinational companies wherever they operate. Financial penalties handed down in proven corruption cases are often very significant.

Disruption to global supply chains and the commercial pressures caused by higher than usual inflation rates are likely to increase the risks of bribery and corruption in certain contexts.

However, greater transparency and collaboration among enforcement authorities, advances in technology and the use of data analytics are providing better platforms to streamline processes and detect potential issues.

## Mitigating activities

We have an enterprise-wide ABAC programme designed to ensure compliance with applicable laws and regulations prohibiting bribery and corruption and related offences. It builds on our business standards and culture to form a comprehensive and practical approach to compliance that responds to the evolving nature of our business. GSK’s ABAC Governance Board oversees and provides programme governance and enterprise risk management which includes representation from key functional areas.

We continue to enhance our controls around third-party engagements to ensure that they are sufficient to meet evolving and emerging risks.

We plan to continue with pre- and post-transaction ABAC due diligence, and to increase the capabilities in the organisation around the onboarding, continual monitoring and management of third parties.
We continue to assess and understand our money laundering risk exposure and mitigate any existing risk.

Our Code of Conduct, culture, and commitment to zero tolerance towards bribery and corruption are integral to how we mitigate this risk. In light of the complexity and geographic breadth of the risk, we constantly evolve our oversight of activities and data, reinforce to our workforce GSK’s clear expectations regarding acceptable behaviours, and maintain regular communications with local markets.

We built our ABAC programme based on best-in-class principles to help us manage risk from the top down and the bottom up. For example, the programme includes senior-level commitment from our Board and leadership, and a data analytics programme to create and embed local key risk indicators to enable targeted intervention and risk management activities. We continue to actively consider improvements to the programme.

The ABAC programme is underpinned by our global ABAC policy and other written standards and controls which address the business activities that give rise to bribery and corruption risks and establish due diligence requirements for the engagement of third parties. The programme also mandates enhanced controls over interactions with government officials and during business development transactions. We have a dedicated team responsible for the programme’s implementation and evolution. The ABAC team works with other groups across the organisation to address and improve controls and monitoring requirements. Audit & Assurance and independent business monitoring teams complement the ABAC team’s work and provide added assurance.

We use issues found during oversight and assurance exercises and investigations to identify areas for specific intervention in our markets and to drive the continuous improvement of the programme.

We provide mandatory ABAC training at least annually to employees and relevant third parties differentiated according to seniority, roles and responsibilities, and geographic location.

Formal and informal ‘Speak Up’ channels are available to report misconduct or non-compliance. The central investigations team reviews and triages allegations of non-compliance and triggers investigation as appropriate.



## Commercial practices

## Risk definition

The risk that GSK or our third parties potentially engage in commercial activities that fail to comply with laws, regulations, industry codes, and internal controls and requirements.

## Risk impact

Failure to engage in activities that are consistent with the letter and spirit of the law, industry regulations, or the Group’s requirements relating to sales and promotion of medicines and vaccines; with appropriate interactions with healthcare professionals (HCPs), organisations and patients; with legitimate and transparent transfers of value; and with pricing and competition (or antitrust) regulations in commercial practices, including trade channel activities and business tendering, could materially and adversely affect our ability to deliver our strategy and long-term priorities. Additionally, it may result in incomplete awareness of the risk/benefit profile of our products and possibly suboptimal treatment of patients and consumers; governmental investigation, regulatory action and legal proceedings brought against the Group by governmental and private plaintiffs which could result in government sanctions, and criminal and/or financial penalties. Any practices that are found to be misaligned with our values and expectations could also result in reputational harm and dilute the trust established with external stakeholders.

## Context

We operate in a highly regulated and extremely competitive biopharma industry, amongst peers who make significant product innovations and technical advances and intensify price competition. Additional external factors impacting our business operations include the ongoing effects of the COVID-19 global pandemic, access limitations to our customers, macroeconomic inflationary dynamics, and pricing pressure across markets. To achieve our strategic objectives, we must continue to develop commercially viable new products and deliver additional uses for existing products that address the needs of patients, consumers, HCPs and payers. Financially, new products/indications carry with them an uncertainty with regards to future success. Product development is costly, lengthy, and uncertain, and carries with it the potential for failure at any stage. Even after successful product development, we face challenges in how we launch, and our competitors' products or pricing strategies could render our assets less competitive. We support product innovation through our continued focus on both in-person and virtual engagement, with a constant focus on our patient.

Once we have an approved medicine or vaccine, it is our obligation to provide important information to the healthcare community in various ways, always in a responsible, legal, and ethical manner. Appropriate product promotion ensures HCPs have access to the information they need, that patients and consumers have the facts about the medicines and vaccines they require, and that products are prescribed, recommended, or used in a manner that provides healthcare benefit. We are committed to the ethical and responsible commercialisation of our products in support of our purpose to improve the quality of human life and get ahead of disease together.

## Mitigating activities

To achieve our strategic objectives, we must meet price expectations of payers, HCPs, consumers, and the community. Our culture provides a guide for how we lead and make decisions. We constantly strive to do the right thing and deliver quality medicines and vaccines and sustain reliable supply to meet customer needs. In doing so, we seek to ensure our actions reflect GSK's values, behaviours, and purpose. We understand the impact of data on our industry and strive to become an organisation that makes data-driven decisions; this approach is aligned to our efforts to become more agile and work at pace. GSK has acted to enhance and improve our policies and standards, application of data analytics and our channel activities. We have evolved policies and standards incrementally to ensure that commercial activities that we undertake or are conducted on our behalf are executed within our established governance. We train employees on relevant information with a focus on interactive learning and elements of behavioural science. All our commercial activities worldwide must conform to high ethical, regulatory, and industry standards. Where local standards differ from global ones, we apply those that are most stringent. Where the standards of an acquired company or joint venture partner differ from our global standards, we remediate legacy policies and implement revisions, so they align.

Our businesses continue to use our internal control framework to support the assessment and management of risks. Business unit risk management and compliance boards, which manage risks across global and in-country business activities, oversee commercial activities and their monitoring programmes. All promotional materials and activities must be reviewed and approved according to our policies and standards and conducted in accordance with local laws and regulations; these requirements seek to ensure that such materials and activities fairly represent the Group's products or services. Where necessary, in the event of misconduct, we have disciplined employees, up to and including termination of contract, and clawed back remuneration from senior management. We have continued to evolve our incentive programme for sales representatives to better recognise and reward individual effort. In nearly all markets, the capped variable pay element of representatives' compensation is evaluated on the basis of individual sales targets.

We allow fair-market value payments to be made by GSK to expert practitioners to speak about our innovative medicines and vaccines during a restricted period in a product’s lifecycle, or when new and competitive data is published. To support this, we have rolled out a global end-to-end process across GSK in 2022 to drive consistent ways of working and efficiencies and strengthen controls through automation and use of data. Where permitted we report payments to individual HCPs as part of our commitment to transparency and responsible disclosure.



## Scientific and patient engagement

## Risk definition

The risk that GSK or our third parties potentially fail to engage externally to gain insights, educate and communicate on the science of our medicines and associated disease areas, and provide grants and donations in a legitimate and transparent manner compliant with laws, regulations, industry codes and internal controls and requirements.

## Risk impact

Without controls in place, the risk could result in real, perceived, or disguised promotion including off-label and prior-authorisation promotion, and real or perceived provision of medical advice. This in turn could lead to criminal investigations and penalties, civil litigation, or competitor complaints. At the same time, if we do not engage fully and appropriately, this could result in patient harm, failure to advance science and innovation, reputational damage, and financial loss. Such consequences may reduce the trust of the public, patients, healthcare professionals, payers, regulators, and governments.

## Context

Scientific and patient engagements are diverse non-promotional activities directed at healthcare professionals, patients, payers, and external stakeholders. Such engagements aim to improve patient care through the exchange or provision of knowledge on the use of our products and related diseases. Scientific and patient engagement with external stakeholder groups is vital to GSK, as a research-based biopharma company that is ambitious for patients and is necessary to advance science and medicine.
We expect our activities to be scientifically sound and accurate, conducted ethically and transparently, and compliant with applicable codes, laws, and regulations. There are many industry and local codes and laws and other regulations that apply (such as Privacy, Data integrity). That means measured risk-taking, rooted in sound ethical considerations, and principles-based decision-making, training, communication, and monitoring of such activities are key to managing the risk and enabling full and appropriate engagement.

## Mitigating activities

Our Chief Medical Officer (CMO) oversees all non-promotional scientific and patient engagement as enterprise risk owner. The GSK Code of Practice is the key internal policy for non-promotional engagement activities. These activities include scientific interactions, support for medical education, advice seeking, gathering insights on unmet needs of patients, scientific communication of our research, and disease awareness.

Since the COVID-19 pandemic we have seen a continued increase in virtual engagements (e.g. with external experts, advisory boards, patient advocacy, patient engagements and scientific congresses). We further developed and modernised our digital approach to HCPs, our patient engagement framework and insight-gathering, and applied our internal principles and policies to this rapidly changing and growing environment.

We continuously improve our internal controls and networks to identify emerging risks early and to support staff to conduct activities in compliance with GSK’s culture and policies, local laws, and regulations, while building effective risk management and management monitoring systems.

## Data ethics and privacy

## Risk definition

The risk that GSK or our third parties potentially fail to ethically collect; use; re-use through artificial intelligence, data analytics or automation; secure; share and destroy personal information in accordance with laws, regulations, and internal controls and requirements.

## Risk impact

Non-compliance with data privacy laws globally could lead to harm to individuals and GSK. It could also damage trust between GSK and individuals, communities, business partners and government authorities. Many countries have increased the enforcement powers of their data protection authorities by allowing them to impose significant fines, impact cross-border data flows, or temporarily ban data processing. Many new national laws also enable individuals to bring collective legal actions against companies such as GSK for failure to follow data privacy laws.

## Context

Data protection and privacy legislation is diverse, with limited global harmonisation or simplification. It is challenging for multinationals to standardise their approach to compliance with data privacy laws. Governments are enforcing compliance with data protection and privacy laws more rigorously. The approach and focus of data protection and privacy regulators also differs between regions and countries, which further creates challenges for global organisations seeking to implement a single harmonised global privacy programme.

Increases in the volume of data processed and advances in technology have resulted in a greater focus on data governance and the ethical use of personal information, over and above compliance with data privacy laws. Companies seeking to foster innovation in artificial intelligence and other new technologies are faced with evolving decisions from global policymakers on how best to promote trust in these systems and avoid unintended outcomes or harmful impacts.



## Principal risks and uncertainties continued

## Data ethics and privacy continued

Additionally, there are a number of emerging laws concerning the localisation of data, restrictions on international transfers and data security, which are changing existing frameworks that GSK has previously relied upon. This increasing trend for data sovereignty affects our ability to drive medical innovation and to effectively operate internationally.

## Mitigating activities

Our General Counsel is GSK’s Enterprise Risk Owner (ERO), and chairs our Privacy Governance Board, which oversees GSK’s overall data privacy operating model. Each GSK business area has appointed a risk owner accountable for overseeing its privacy risks, supported by privacy leaders within their business. In countries where local data privacy laws require appointment of a Data Protection Officer (DPO), GSK has made such appointments, including an EU DPO.

As a result of GSK’s focus on technology, data-driven science, use of artificial intelligence/machine learning and evolving global data strategy, we have sought to address the key risks by creating a new team with Group Legal and Compliance responsible for advising on global digital privacy and cybersecurity strategy. The ERO has appointed a Head of Digital, Privacy and Cybersecurity (Head of DPC), who has day-to-day accountability for designing and implementing the control framework.
The Head of DPC leads a global, cross-functional core team of digital- and privacy-qualified attorneys and privacy compliance professionals, supported by a network of privacy leaders within business units/functions, privacy contracts locally, and the wider Legal and Compliance team. GSK has a global privacy framework based on the EU General Data Protection Regulation, which is deployed in every market based on factors including the robustness of local privacy legislation, established data protection authorities, and GSK’s footprint. Beyond those countries, we are deploying a proportionate control framework to set up minimum privacy standards irrespective of any applicable legislation.

Our core team is responsible for:

– operating and improving the centralised global privacy control framework

– continuously assessing and providing relevant and proportionate controls and aid to non-deployed markets

– monitoring new, or changing, laws and adapting the privacy framework accordingly

– deploying a comprehensive training programme to drive greater awareness and accountability for managing personal information across the entire organisation

We certify key GSK privacy network roles have sufficient training and experience to carry out their roles effectively. We continuously improve our processes, such as issue identification, reporting and handling, through monitoring. Our core team works with the business to ensure we build in privacy controls into all existing and new business initiatives, as well as ensuring we meet our accountability obligations in accordance with global data protection and privacy laws.

## Research practices

## Risk definition

The risk that GSK or our third parties potentially fail to adequately conduct ethical and credible pre-clinical and clinical research, collaborate in research activities compliant with laws, regulations, and internal controls and requirements.

## Risk impact

The potential impacts of the risk include harm to human subjects, reputational damage, failure to obtain the necessary regulatory approvals for our products, governmental investigation, legal proceedings brought against the GSK by governmental and private plaintiffs (product liability suits and claims for damages), loss of revenue due to inadequate patent protection or inability to supply our products, and regulatory action such as fines, penalties, or loss of product authorisation. Poor data integrity and governance could compromise GSK’s R&D efforts and negatively impact our reputation. Any of these could materially and adversely affect our financial results and damage the trust of patients and customers.

## Context

Research involving animals can raise ethical concerns. In many cases, however, research involving animals is the only way to investigate the effects of a potential new medicine in a living body other than in humans. Animal research provides critical information about the causes and mechanisms of diseases and therefore remains a vital part of our research. We continually seek ways in which we can minimise our use of animals in research, development, and testing, while complying with regulatory requirements and reducing the impact on the animals used. Human subject research is critical to assessing and demonstrating the safety and efficacy of our investigational products or further evaluating our products once they have been approved. This research includes clinical trials in healthy volunteers and patients and adheres to regulations and high ethical, medical, and scientific standards. We disclose the results of this research externally regardless of whether they reflect positively or negatively on our products, so that the scientific community can learn from the outcomes of our research. We also work with human biological samples which are fundamental to the discovery, development, and safety monitoring of our products.



## Principal risks and uncertainties continued

## Research practices continued

We are committed to managing human biological samples in accordance with relevant laws, regulations, and ethical principles, and in a manner that respects the interests of sample donors. Data is pivotal to our R&D strategy, and we are maximising the use of data to serve patients. Governing our data in accordance with relevant laws, regulations, contractual obligations, expectations, and our culture across privacy, information security, and data integrity is essential.

We use a wide variety of biological materials in the discovery, research, and development of our assets. Through the Convention on Biological Diversity (CBD) and the Nagoya Protocol, the international community has established a global framework regulating access to, and use of, genetic resources of non-human origin in research and development. We support the principles of access to, and benefit-sharing of, genetic resources as outlined in the CBD and the Nagoya Protocol. We also recognise the importance of appropriate, effective, and proportionate implementation measures at national and regional levels.

## Mitigating activities

The Research Practices risk is overseen by an enterprise framework that seeks to strengthen governance across R&D. Under the leadership of the Research Practices Enterprise Risk Owner, management of the risk takes a pragmatic approach to information sharing, streamlining risk identification and escalation while ensuring ownership of risk mitigation stays with the business.
We have an established Office of Animal Welfare, Ethics and Strategy and Risk (OAWESR), led by our Chief Veterinary Officer, which supports the humane and responsible care of animals, carries out ethical reviews and independent scientific reviews of animal studies, and shares knowledge and advocates for the application of non-animal alternatives. The OAWESR provides a framework of animal welfare governance; defines and provides oversight for training in animal care; promotes the replacement, refinement and reduction of animal research; conducts quality assessments; manages a programme of external animal diligence; and develops and deploys strategies for reproducing experiments and translating them to human clinical end points. Ensuring we implement and maintain proper data governance controls remains an important priority, especially as our scientific strategy is evolving to take advantage of the breadth of our data (for example: genomics and artificial intelligence and machine learning). We focus on building data integrity, privacy and usage controls into our internal control framework. Quality assurance teams conduct audits to provide independent business monitoring of our internal controls. Our R&D organisation maintains and controls pre-publication procedures to guard against public disclosure before patent applications are filed. In addition, because a lack of data integrity in preparing patent application data and information can lead to a loss of patent protection, legal experts collaborate with R&D to support the review process for new patent applications. Our R&D organisation also collaborates with legal experts throughout the development of our assets to take account of any relevant third-party patent rights.

# Environment, health, and safety (EHS)

## Risk definition

The risk that GSK or our third parties potentially fail to ensure appropriate controls and governance of the organization’s assets, facilities, infrastructure, and business activities, including execution of hazardous activities, handling of hazardous materials, or release of substances harmful to the environment that disrupts supply or harms employees, third parties or the environment.

## Risk impact

Failure to manage EHS risks could lead to significant harm to people, the environment and the communities in which we operate, fines, inability to meet stakeholder expectations and regulatory requirements, litigation or regulatory action, and damage to the company’s reputation, which could materially and adversely affect our financial results.

## Context

GSK is subject to the health, safety and environmental laws of various jurisdictions. These laws impose duties to protect people, the environment and the communities in which we operate.

## Mitigating activities

The GSK Leadership Team is responsible for EHS governance and risk oversight. They ensure there is an effective control framework ‘in-place’ and ‘in-use’ to manage the EHS risks, impacts, and legal compliance issues in each of our businesses. This includes assigning responsibility to senior managers for providing and maintaining our controls and for ensuring that tiered monitoring and governance processes are in place within their business units. Function leaders ensure that the EHS control framework is implemented effectively in their respective business area, that it is compliant with applicable laws and regulations, and that it is adequately resourced, maintained, communicated, and monitored. Every employee and qualified contractor acting on behalf of GSK is personally responsible for ensuring that they follow all applicable local standard operating procedures. Our risk-based, proactive approach is articulated in our global EHS policy and detailed in our global EHS standards, against which we audit all our operations to ensure compliance. We ensure hazards are appropriately controlled through the design of facilities, equipment and systems. These rigorous procedures, when applied correctly, put effective barriers in place to protect employees’ health and safety. In 2020 we created a safety improvement plan, focusing on Life Saving Rules, Safety Leadership and Warehouse Safety. All significant milestones for these programmes were delivered in 2022 according to plan. Our Safety Leadership Experience and warehouse improvements will continue implementation into 2023.



## Information security

## Risk definition

The risk that GSK or our third parties potentially fail to ensure appropriate controls and governance over unauthorised access, disclosure, theft, unavailability or corruption of GSK’s information, key systems or technology infrastructure.

## Risk impact

Failure to adequately protect our information and systems may cause harm to our patients, workforce and customers, disruption to our business and/or loss of commercial or strategic advantage, regulatory sanction or damage to our reputation.

## Context

The external environment continues to be extremely challenging, making it hard to keep pace with increasingly sophisticated cyber threats. This is due to many factors including increased geopolitical conflict and digital nationalism, rising frequency and severity of data breaches and growing capability and sophistication of bad actors and cyber criminals. GSK’s business relies on operating a highly connected information network of internal and external systems, which hold confidential research and development, manufacturing, commercial, workforce and financial data. This means that our systems and information have been and will continue to be the target of cyberattacks. Acceleration in the use of digital, data and analytics and cloud computing capabilities to drive GSK’s pipeline and performance requires us to continuously adapt and strengthen our controls and defensive capabilities. GSK also relies on third-party contractors, partners and suppliers who face similar cyber threats and this continues to be a vector of risk to manage as well.

## Mitigating activities

## Cyber Security Office and Cyber Maturity Programme

GSK has a Cyber Security Office and our Chief Information Security Officer is responsible for identifying and putting in place measures to help GSK mitigate and manage cyber security risks. This includes active monitoring and initiating remediation or other actions in response to cyber security intelligence and threats, while also enhancing our capabilities through an ongoing programme of investment in people, process and technology to improve our ability to prevent, detect, respond and recover from any cyber security incidents. A risk based Third-party security risk management program is also in place to aid in assessing cyber security risk during selection of third parties and also provide ongoing monitoring of our external partner and supplier ecosystem.

## Information Security Governance

The Cyber Security Office periodically provides updates on key information security risks and issues, as well as progress reports on the Cyber Maturity Programme to both the Risk Oversight & Compliance Council and the Audit & Risk Committee. The Information Security Enterprise Risk Plan and Cyber Maturity Programme are overseen by the Chief Digital and Technology Officer as well as the Chief Financial Officer.

## Cyber Security Awareness, Training and Readiness

Cyber Security Awareness and Training programs including phishing simulation programs are in place to increase awareness of cyber related risks and reinforce the message that security is everyone’s responsibility at GSK. Periodic crisis simulation tabletop exercises are planned at various levels of the organisation to test our ability to respond to cyber incidents.

## Compliance with various governmental cyber security regulations

The Cyber Security Office, with the General Counsel’s guidance, works to stay abreast of various emergent governmental regulations, emergent trends and compliance expectations regarding cyber security or information security. As new regulatory guidance becomes available, remedial compliance related actions are put in place as appropriate.



## Supply continuity

## Risk definition

The risk that GSK or our third parties potentially fail to deliver a continuous supply of compliant finished product or respond effectively to a crisis incident in a timely manner to recover and sustain critical supply operations.

## Risk impact

We recognise how important the continuity of supply of our products is to the patients who rely on them. Supply disruption can lead to:

– Product shortages and product recalls

– Regulatory intervention

– Reputational harm

– Lost sales revenue

Consequently, we need sophisticated end-to-end supply chain management with robust crisis management and business continuity plans in place to respond.

## Context

We run our supply chains in a continually evolving, highly-regulated environment. There is no single set of global regulations which governs the manufacture and distribution of medicines, and we must adhere to the requirements in all those markets in which we licence, sell or manufacture our products. We rely upon our internal Quality Management System and our Internal Control Framework to ensure we continue to preserve our licence to operate.

Our complex end-to-end supply chains often involve third-party suppliers, from Active Pharmaceutical Ingredient (API) manufacturers and raw material suppliers through to Third-Party Logistics Providers and contract engineering firms. We embed integrated risk management into our sourcing and day to day business processes, alongside our Third-Party Oversight programme.

External factors continued to challenge supply continuity in 2022. In the early part of the year COVID-19 continued to disrupt our sourcing of biosciences materials across our Medicines and Vaccines supply chains (e.g. vials, syringes and single-use systems components). The Ukraine conflict has resulted in supply disruption to the region. To manage these disruptions, we deployed bespoke de-risking plans using crisis and continuity plans to manage the detail and mitigate the risk of supply continuity problems, e.g. by dual sourcing of materials or re-routing of shipments to avoid conflict zones. Keeping our patients supplied with their medicines is our priority.
New technology and modality platforms within supply chains are changing the requirements for the skillsets of people working in this field. We have implemented a new Chemistry, Manufacturing and Controls Operating Model in 2022. This brings cross-fertilisation of talent focus on the skills needed for the future for innovative manufacturing.

Industrial relations are also a current risk to supply continuity, with the threat of industrial action being averted in our UK manufacturing sites through successful dialogue with unions. Continued business monitoring is in place to assess the risk of the spread of industrial relations challenges resulting from global cost of living pressures.

## Mitigating activities

## Risk Management

Our Medicines and Vaccine supply chains are set up to ensure sustainable global supply. The GSK Internal Control Framework drives our approach to risk management, and it has been designed to identify emerging new risks and support clear decision making. Risk oversight is managed through a hierarchy of Risk Management and Compliance Boards to assure risk mitigation (including identifying new and emerging threats).

## Inventory Management

Supply chain governance committees in Medicines and Vaccines closely monitor the inventory status and delivery of our products. Our core commercial cycle links supply chain forecasting with our commercial ambition. It is designed to reduce the risk of demand fluctuations and manage temporary shortages in supply. We periodically review each node of our supply chains to ensure we hold adequate safety stocks, whilst balancing working capital. We put particular emphasis on mitigating supply risks associated with medically-critical, high-revenue products and new product launches, for example using dual sourcing for key products or APIs. We use the monthly Performance Management Process across our supply chains to monitor business activity and highlight adverse trends in supply, operations, budget and workforce capability.

## Business continuity

Crisis management and business continuity plans are in place across our supply chains, which include authorised response and recovery strategies, key areas of responsibility and clear communication routes. We regularly use business continuity plans to manage potential supply disruptions. Our manufacturing sites have crisis management plans in place. These plans are tested at least annually to ensure maintenance of core skills in crisis management.



# Shareholder information

## Demerger and Share Consolidation

On Monday 18 July 2022, the company completed the demerger of the Consumer Healthcare business from the Group to form the Haleon Group (Demerger). Under the terms of the Demerger, shareholders received one Haleon plc share for each GSK plc share held at the record time of 6.00 pm (UK) on Friday 15 July 2022.

Following the Demerger, the company consolidated its share capital (Share Consolidation). The Share Consolidation took effect on Tuesday 19 July 2022 and resulted in shareholders receiving four new GSK plc shares of nominal value 31 \( ^{1} \) / \( _{4} \)  pence each for every five GSK plc shares of nominal value 25 pence each held at the record time of 8.00 pm (UK) on Monday 18 July 2022.
The circular in relation to the Demerger and the Share Consolidation (Circular) and the prospectus regarding the admission of Haleon’s ordinary shares to the premium listing segment of the Official List of the Financial Conduct Authority (FCA) and trading on the Main Market of the London Stock Exchange (LSE) were published by the company and Haleon plc respectively on Wednesday 1 June 2022.

## Share capital and control

Details of our issued share capital and the number of shares held in Treasury as at 31 December 2022 can be found in Note 37 to the financial statements, 'Share capital and share premium account'.

Our Ordinary Shares are listed on the LSE and are also quoted on the New York Stock Exchange (NYSE) in the form of American Depositary Shares (ADS). Each ADS represents two Ordinary Shares. For details of listed debt and where it is listed refer to Note 30 to the financial statements, 'Net debt'.

Holders of Ordinary Shares and ADS are entitled to receive dividends (when declared) and the company’s Annual Report. They are also entitled to attend, speak, appoint proxies and exercise voting rights at general meetings of the company.

There are no restrictions on the transfer, or limitations on the holding, of Ordinary Shares and ADS and no requirements to obtain approval prior to any transfers. No Ordinary Shares or ADS carry any special rights with regard to control of the company and there are no restrictions on voting rights. Major shareholders have the same voting rights per share as all other shareholders. There are no known arrangements under which financial rights are held by a person other than the holder of the shares and no known agreements on restrictions on share transfers or on voting rights.

Shares acquired through the Group’s employee share plans rank equally with the other shares in issue and have no special rights. The trustees of our Employee Share Ownership Plan trusts have waived their rights to dividends on shares held by those trusts.

## Exchange controls and other limitations affecting holders

Other than certain economic sanctions, which may be in force from time to time, there are currently no applicable laws, decrees or regulations in force in the UK restricting the import or export of capital or restricting the remittance of dividends or other payments to holders of the company’s shares who are non-residents of the UK.
Similarly, other than certain economic sanctions which may be in force from time to time, there are no limitations relating only to non-residents of the UK under English law or the company’s Articles of Association on the right to be a holder of, and to vote in respect of, the company’s shares.

## Interests in voting rights

Other than as stated below, as far as we are aware, there are no persons with significant direct or indirect holdings in the company. Information provided to the company pursuant to the FCA’s Disclosure Guidance and Transparency Rules (DTR 5) is published on a Regulatory Information Service and on the company’s website, gsk.com.

The company has received notifications in accordance with DTR 5 of the following notifiable interests in the voting rights in the company’s issued share capital:

<table><tr><td rowspan="2"></td><td colspan="2">31 December 2022</td><td colspan="2">3 March 2023</td></tr><tr><td>No. of voting rights</td><td>Percentage of total voting rights \( ^{(1)} \)</td><td>No. of voting rights \( ^{(1)} \)</td><td>Percentage of total voting rights \( ^{(1)} \)</td></tr><tr><td>BlackRock, Inc</td><td>231975,400 \( ^{(2)} \)</td><td>5.69%</td><td>231975,400 \( ^{(2)} \)</td><td>5.69%</td></tr><tr><td>Dodge &amp; Cox</td><td>253,464,108 \( ^{(3)} \)</td><td>5.04%</td><td>253,464,108 \( ^{(3)} \)</td><td>5.04%</td></tr></table>

(1) Percentage of total voting rights at the date of notification to the company.

(2) Comprising an indirect interest in 229,134,683 Ordinary Shares and a holding of 2,840,717 Qualifying Financial Instruments (Contracts for Difference).

(3) Comprising an indirect interest in 99,377,874 Ordinary Shares and 154,086,234 ADS.

The company has not acquired or disposed of any interests in its own shares during the period under review.



## Shareholder information continued

## Share capital and control continued

## Share buy-back programme

The Board has been authorised to issue and allot Ordinary Shares under Article 9 of the company’s Articles of Association. The power under Article 9 and the authority for the company to make purchases of its own shares are subject to shareholder authorities which are sought on an annual basis at our Annual General Meeting (AGM). Any shares purchased by the company may be cancelled, held as Treasury shares or used for satisfying share options and grants under the Group’s employee share plans.

Our programme covers purchases of shares for cancellation or to be held as Treasury shares, in accordance with the authority renewed by shareholders at the AGM in May 2022, when the company was authorised to purchase a maximum of just over 508 million shares. Details of shares purchased, cancelled, held as Treasury shares and subsequently transferred from Treasury to satisfy awards under the Group’s employee share plans are disclosed in Note 37 to the financial statements, ‘Share capital and share premium account’.

In determining specific share repurchase levels, the company considers the development of free cash flow during the year. No Treasury shares have been purchased since 2014.

The company confirms that it does not currently intend to make any market purchases in 2023. The company will review the potential for future share buy-backs in line with its usual annual cycle and subject to return and ratings criteria.

## Market capitalisation

The market capitalisation, based on shares in issue excluding Treasury shares, of GSK at 31 December 2022 was £58.9 billion. At that date, GSK was the 10 \( ^{th} \)  largest company by market capitalisation in the FTSE index.

## Nature of trading market

The following table sets out, for the periods indicated, the high and low middle market closing prices for the company’s Ordinary Shares on the LSE and for the ADS on the NYSE.

<table><tr><td rowspan="3"></td><td colspan="2">Ordinary Shares</td><td colspan="2">ADS</td></tr><tr><td colspan="2">UK£ per share</td><td colspan="2">US$ per share</td></tr><tr><td>High</td><td>Low</td><td>High</td><td>Low</td></tr><tr><td>March 2023*</td><td>14.42</td><td>14.22</td><td>34.66</td><td>34.26</td></tr><tr><td>February 2023</td><td>15.03</td><td>14.20</td><td>36.43</td><td>34.27</td></tr><tr><td>January 2023</td><td>14.51</td><td>13.87</td><td>35.61</td><td>34.48</td></tr><tr><td>December 2022</td><td>14.92</td><td>13.88</td><td>37.92</td><td>34.78</td></tr><tr><td>November 2022</td><td>14.48</td><td>13.24</td><td>34.59</td><td>31.58</td></tr><tr><td>October 2022</td><td>14.29</td><td>13.19</td><td>33.29</td><td>30.01</td></tr><tr><td>September 2022</td><td>13.78</td><td>12.96</td><td>32.47</td><td>28.67</td></tr><tr><td>Quarter ended 31 December 2022</td><td>14.92</td><td>13.20</td><td>37.92</td><td>30.00</td></tr><tr><td>Quarter ended 30 September 2022</td><td>18.23</td><td>12.96</td><td>44.53</td><td>28.67</td></tr><tr><td>Quarter ended 30 June 2022</td><td>18.31</td><td>16.72</td><td>47.70</td><td>41.98</td></tr><tr><td>Quarter ended 31 March 2022</td><td>17.27</td><td>15.01</td><td>47.66</td><td>40.17</td></tr><tr><td>Quarter ended 31 December 2021</td><td>16.19</td><td>13.80</td><td>44.44</td><td>38.13</td></tr><tr><td>Quarter ended 30 September 2021</td><td>15.26</td><td>13.83</td><td>42.33</td><td>38.05</td></tr><tr><td>Quarter ended 30 June 2021</td><td>14.36</td><td>12.78</td><td>40.66</td><td>35.82</td></tr><tr><td>Quarter ended 31 March 2021</td><td>14.14</td><td>11.91</td><td>39.24</td><td>33.61</td></tr><tr><td>Year ended 31 December 2021</td><td>16.19</td><td>13.80</td><td>44.44</td><td>38.13</td></tr><tr><td>Year ended 31 December 2020</td><td>14.68</td><td>12.92</td><td>39.17</td><td>33.42</td></tr><tr><td>Year ended 31 December 2019</td><td>18.19</td><td>14.36</td><td>47.32</td><td>37.83</td></tr><tr><td>Year ended 31 December 2018</td><td>16.22</td><td>12.43</td><td>41.94</td><td>35.49</td></tr></table>

* to 3 March 2023



## Analysis of shareholdings at 31 December 2022

<table><tr><td></td><td>Number of accounts</td><td>% of total accounts</td><td>% of total shares</td><td>Number of shares</td></tr><tr><td>Holding of shares</td><td></td><td></td><td></td><td></td></tr><tr><td>Up to 1,000</td><td>48,487</td><td>75.32</td><td>0.34</td><td>14,478,112</td></tr><tr><td>1,001 to 5,000</td><td>11,929</td><td>18.53</td><td>0.58</td><td>25,184,737</td></tr><tr><td>5,001 to 100,000</td><td>2,944</td><td>4.57</td><td>1.24</td><td>53,490,777</td></tr><tr><td>100,001 to 1,000,000</td><td>682</td><td>1.06</td><td>5.52</td><td>237,893,148</td></tr><tr><td>Over 1,000,000</td><td>333</td><td>0.52</td><td>92.32</td><td>3,980,296,567</td></tr><tr><td></td><td>64,375</td><td>100.00</td><td>100.00</td><td>4,311,343,341</td></tr><tr><td>Held by</td><td></td><td></td><td></td><td></td></tr><tr><td>Institutional and Corporate holders</td><td>2,383</td><td>3.70</td><td>61.71</td><td>2,660,734,974</td></tr><tr><td>Individuals and other corporate bodies</td><td>61,990</td><td>96.30</td><td>13.46</td><td>580,447,710</td></tr><tr><td>Guaranty Nominees Limited (ADR Programme)</td><td>1</td><td>0.00</td><td>19.79</td><td>853,035,897</td></tr><tr><td>Held as Treasury shares by GSK</td><td>1</td><td>0.00</td><td>5.04</td><td>217,124,760</td></tr></table>

JP Morgan Chase Bank NA is the Depositary for the company’s American Depository Receipt (ADR) programme. The company’s ADS are listed on the NYSE. Ordinary Shares representing the company’s ADR programme, which is managed by the Depositary, are registered in the name of Guaranty Nominees Limited. At 3 March 2023, Guaranty Nominees Limited held 852,687,041 Ordinary Shares representing 20.82% of the issued share capital (excluding Treasury shares).

At 3 March 2023, the number of holders of Ordinary Shares in the US was 852 with holdings of 716,804 Ordinary Shares, and the number of registered holders of ADS was 16,757 with holdings of 426,343,520 ADS. Certain of these Ordinary Shares and ADS were held by brokers or other nominees. As a result, the number of holders of record or registered holders in the US is not representative of the number of beneficial holders or of the residence of beneficial holders.

## Dividends

The company pays dividends quarterly and continues to return cash to shareholders through its dividend policy. Dividends remain an essential component of total shareholder return and GSK recognises the importance of dividends to shareholders.

On 23 June 2021, at the new GSK Investor Update, GSK set out that from 2022 a progressive dividend policy will be implemented guided by a 40 to 60 percent pay-out ratio through the investment cycle. The dividend policy, the total expected cash distribution, and the respective dividend pay-out ratios for GSK remain unchanged.

## Dividends per share

The table below sets out the dividend per share and per ADS for the last five years. The dividend per ADS is translated into US dollars at applicable exchange rates.

<table><tr><td>Year</td><td>pence</td><td>US$ \( ^{10} \)</td></tr><tr><td>2022</td><td>61.25 \( ^{12} \)</td><td>— \( ^{13} \)</td></tr><tr><td>2021</td><td>80</td><td>2.16</td></tr><tr><td>2020</td><td>80</td><td>2.12</td></tr><tr><td>2019</td><td>80</td><td>2.01</td></tr><tr><td>2018</td><td>80</td><td>2.08</td></tr></table>

(1) An annual fee of $0.03 per ADS (or $0.0075 per ADS per quarter) will be charged by the Depositary. The amounts shown are the dividends paid per ADS before the annual fee is charged.

(2) Adjusted for the Share Consolidation (2022 only; prior years have not been adjusted). Dividends declared and paid in respect of 2022 were 14p per share for Q1 2022, 16.25p per share for Q2 2022 and 13.75p per share for Q3 2022. A dividend of 13.75p per share has been declared for Q4 2022.

(3) The Q4 2022 ordinary dividend receivable by ADS holders will be calculated based on the exchange rate on 13 April 2023. The cumulative dividend receivable by ADS holders for Q1, Q2 and Q3 2022 was $105.
GSK has previously stated that it expected to declare a 27p per share dividend for the first half of 2022, a 22p per share dividend for the second half of 2022 and a 45p per share dividend for 2023 (before the Share Consolidation) but that these targeted dividends per share would increase in step with the Share Consolidation to maintain the same aggregate dividend pay-out in absolute Pound Sterling terms. Accordingly, using the consolidation ratio, GSK's expected dividend for the fourth quarter of 2022 converts to 13.75p per new Ordinary Share, this results in an expected total dividend for the second half of 2022 of 27.5p per new Ordinary Share. The expected dividend for 2023 is now 56.5p per new Ordinary Share, in line with the original expectation converted for the Share Consolidation and rounded up.

Details of the dividends declared, the amounts and the payment dates are given in Note 16 to the financial statements, 'Dividends'.

## 2023 Dividend calendar

<table><tr><td>Quarter</td><td>Ex-dividend date</td><td>Record date</td><td>Payment date</td></tr><tr><td>Q4 2022</td><td>23 February 2023</td><td>24 February 2023</td><td>13 April 2023</td></tr><tr><td>Q1 2023</td><td>18 May 2023</td><td>19 May 2023</td><td>13 July 2023</td></tr><tr><td>Q2 2023</td><td>17 August 2023</td><td>18 August 2023</td><td>12 October 2023</td></tr><tr><td>Q3 2023</td><td>16 November 2023</td><td>17 November 2023</td><td>11 January 2024</td></tr><tr><td>Q4 2023</td><td>22 February 2024</td><td>23 February 2024</td><td>11 April 2024</td></tr></table>



## Financial calendar 2023

<table><tr><td>Event</td><td>Date</td></tr><tr><td>Quarter 1 Results announcement</td><td>26 April 2023</td></tr><tr><td>Annual General Meeting</td><td>3 May 2023</td></tr><tr><td>Quarter 2 Results announcement</td><td>26 July 2023</td></tr><tr><td>Quarter 3 Results announcement</td><td>1 November 2023</td></tr><tr><td>Preliminary/Quarter 4 Results announcement</td><td>31 January 2024</td></tr><tr><td>Annual Report publication</td><td>February/March 2024</td></tr><tr><td>Annual Report distribution</td><td>March 2024</td></tr></table>

Information about the company, including the share and ADS price, is available on our website at gsk.com. Information made available on the website does not constitute part of this Annual Report.

## Results announcements

Results announcements are issued to the LSE and are available on its news service. They are also sent to the US Securities and Exchange Commission (SEC) and the NYSE, issued to the media and made available on our website.

## Financial reports

The company publishes an Annual Report which is made available on our website from the date of publication. Shareholders may elect to receive notification by email of the publication of Annual Reports by registering on www.shareview.co.uk, and may also elect to receive a printed copy of the Annual Report by contacting our registrar, Equiniti Limited.

Copies of previous Annual Reports are available on our website. Printed copies can also be obtained from our registrar (see page 302 for the contact details).

## Annual General Meeting 2023

Our Annual General Meeting (AGM) will be held at 2.30pm (UK time) on Wednesday, 3 May 2023 at the Sofitel London Heathrow, Terminal 5, London Heathrow Airport, TW6 2GD and will also be broadcast live for you to join electronically.

The AGM is the company’s principal forum for communication with private shareholders. In addition to the formal AGM business, there will be a presentation by the CEO on the performance of the Group and its future development. There will be an opportunity for questions to be asked of the Board and Chairs of the Board’s Committees will be available to take questions relating to their roles.

Further details on how to access the AGM electronically or attend in person, ask questions and vote, can be found in the notice of Annual General Meeting 2023 (AGM Notice) which is available on our website at gsk.com.

Investors holding shares through a nominee service should arrange with that service for them to be appointed as a proxy in respect of their shareholding to attend and vote at the meeting electronically.
ADS holders wishing to attend the meeting electronically should refer to the AGM Notice for details on how to request a proxy appointment from the Depositary, JP Morgan Chase Bank NA. This will enable them to attend, ask questions and vote, all electronically, on the business to be transacted at the meeting. ADS holders are reminded that if they do not instruct the Depositary as to the way in which the shares represented by their ADS should be voted by completing and returning the voting card provided by the Depositary, their shares will not be voted.

## Documents on display

The Articles of Association of the company and Directors' service contracts or, where applicable, letters of appointment between Directors and the company or any of its subsidiaries (and any side letters relating to severance terms and pension arrangements) are available for inspection at the company's registered office and will be made available for inspection at the AGM.

## Tax information for shareholders

A summary of certain UK tax and US federal income tax consequences for holders of shares and ADSs who are citizens of the UK or the US is set out below. It is not a complete analysis of all the possible tax consequences of the purchase, ownership or sale of these securities. It is intended only as a general guide. Holders are advised to consult their advisers with respect to the tax consequences of the purchase, ownership or sale of their shares or ADSs and the consequences under state and local tax laws in the US and the implications of the current UK/US tax conventions.
US holders of ADS generally will be treated as the owners of the underlying shares for the purposes of the current UK/US double taxation conventions relating to income and gains (Income Tax Convention), estate and gift taxes (Estate and Gift Tax Convention), and for the purposes of the Internal Revenue Code of 1986, as amended.



## Shareholder information continued

Tax information for shareholders continued

## UK shareholders

This summary only applies to a UK resident shareholder that holds shares as capital assets.

## Taxation of dividends

For the 2022/23 UK tax year, UK resident individuals are entitled to a dividend tax allowance of up to £2,000, so that the first £2,000 of dividends received in a tax year will be free of tax. Dividends in excess of this allowance will be taxed at 8.75% for basic rate taxpayers, 33.75% for higher rate taxpayers and 39.35% for additional rate taxpayers. Note that from 6 April 2023 the dividend allowance will be reduced to £1,000, and that from 6 April 2024 the dividend allowance will be reduced again to £500.

UK resident shareholders that are corporation taxpayers should note that dividends payable on ordinary shares are generally entitled to exemption from corporation tax.

## Taxation of capital gains

UK resident shareholders may be liable for UK tax on gains on the disposal of shares or ADS.

For disposals by individuals in the 2022/23 UK tax year, a taxable capital gain accruing on a disposal of shares or ADS will be taxed at 10% for basic rate taxpayers, or 20% if, after all allowable deductions, the individual's taxable income for the year exceeds the basic rate income tax banding. Note this is following the use of any exemptions available to the individual taxpayer such as the annual exempt amount.

Corporation taxpayers may be entitled to an indexation allowance which applies to reduce capital gains to the extent that such gains arise due to inflation. Indexation allowance may reduce a chargeable gain but will not create an allowable loss. For assets acquired on or before 1 January 2018, legislation in the Finance Act 2018 freezes the level of indexation allowance that is given in calculating a company's chargeable gains at the value that would apply to the disposal of an asset in December 2017. For assets acquired from 1 January 2018 onwards, legislation in the Finance Act 2018 removes any indexation allowance on disposal.

## Inheritance tax

Individual (UK-domiciled or otherwise) shareholders may be liable to UK inheritance tax on the transfer of shares or ADS. Exposure to a UK Inheritance tax charge typically occurs on death of the asset owner. However, transfers of shares (other than commercial sales) within 7 years of death remain relevant to any inheritance tax exposure at death. Further, transfers to a trust arrangement during lifetime can give rise to an immediate inheritance tax charge.

Tax may be charged on the amount by which the value of the shareholder’s estate is reduced as a result of any transfer by way of lifetime gift or other disposal at less than full market value. In the case of a bequest on death, tax may be charged on the value of the shares at the date of the shareholder’s death. Where an exposure to UK inheritance tax and US estate or gift tax exists careful planning must be undertaken to understand the opportunity to utilise the US/UK Estate and Gift Double Tax Convention to manage tax credits and avoid double taxation. The overall exposure will be dependent on the specific circumstances of each situation and it’s also important to note that tax charges may arise in other jurisdictions. Bespoke advice tailored to an individual’s personal circumstances should therefore be obtained from a tax professional.

## Stamp duty and stamp duty reserve tax

UK stamp duty and/or stamp duty reserve tax (SDRT) will, subject to certain exemptions, be payable on the transfer of shares at a rate of 0.5% (rounded up to the nearest £5 in the case of stamp duty) of the consideration for the transfer. Notwithstanding this, provided that an instrument is executed in pursuance of the agreement that gave rise to the charge to SDRT and that instrument is stamped within six years of the agreement (including being stamped as exempt) any SDRT charge should be cancelled and any SDRT which has already been paid will be repaid. Where listed shares are transferred to a company connected to the transferor the chargeable consideration will be deemed to be not less than the market value of the shares transferred. This market value override also applies where non-listed shares are transferred to a company connected to the transferor where the consideration includes an issue of shares.

## US shareholders

This summary only applies to a shareholder (who is a citizen or resident of the US or a domestic corporation or a person that is otherwise subject to US federal income tax on a net income basis in respect of the shares or ADS) that holds shares or ADS as capital assets, is not resident in the UK for UK tax purposes and does not hold shares for the purposes of a trade, profession or vocation that is carried on in the UK through a branch or agency.

The summary also does not address the tax treatment of holders that are subject to special tax rules, such as banks, tax-exempt entities, insurance companies, dealers in securities or currencies, persons that hold shares or ADS as part of an integrated investment (including a 'straddle') comprised of a share or ADS and one or more other positions, and persons that own (directly, indirectly or constructively) 10% or more of the company's stock (by vote or value), nor does it address tax treatment that may be applicable as a result of international income tax treaties.

## Taxation of dividends

The gross amount of dividends received is treated as foreign source dividend income for US tax purposes. It is not eligible for the dividend received deduction allowed to US corporations. Dividends on ADS are payable in US dollars; dividends on Ordinary Shares are payable in Sterling. Dividends paid in Sterling will be included in income in the US dollar amount calculated by reference to the exchange rate on the day the dividends are received by the holder. Subject to certain exceptions for short-term or hedged positions, an individual eligible US holder will be subject to US taxation at a maximum federal rate of 23.8% plus applicable state and local tax in respect of qualified dividends. A qualified dividend as defined by the US Internal Revenue Service (IRS) is a dividend that meets the following criteria:

1. Must be issued by a US corporation, a corporation incorporated in a US possession, or a corporation that is eligible for the benefits of a comprehensive income tax treaty deemed satisfactory, as published by the IRS.



## Shareholder information continued

## Tax information for shareholders continued

2. The dividends are not of a type listed by the IRS as dividends that do not qualify.

3. The required dividend holding period has been met. The shares must have been owned by you for more than 60 days of the 'holding period' – which is defined as the 121-day period that begins 60 days before the ex-dividend date, or the day in which the stock trades without the dividend priced in. For example, if a stock's ex-dividend date is 1 October, the shares must be held for more than 60 days in the period between 2 August and 30 November of that year in order to count as a qualified dividend.

Dividends that are not qualified are subject to taxation at the US federal graduated tax rates, at a maximum rate of 40.8%. Some types of dividends are automatically excluded from being qualified dividends, even if they meet the other requirements. These include (but are not limited to):

1. Capital gains distributions

2. Dividends on bank deposits

3. Dividends held by a corporation in an Employee Stock Ownership Plan (ESOP)

4. Dividends paid by tax-exempt corporations.

US state and local tax rates on qualified and non-qualified dividends may vary and would be assessed in addition to the federal tax rates communicated above.

## Taxation of capital gains

Generally, US holders will not be subject to UK capital gains tax, but will be subject to US tax on capital gains realised on the sale or other disposal of shares or ADS. Such gains will be long-term capital gains (subject to reduced rates of taxation for individual holders) if the shares or ADS were held for more than one year, from the date the shares were vested/released. Short-term capital gains can be subject to taxation of rates of up to 40.8%, whereas long-term capital gains may be subject to rates of up to 23.8%. State and local tax rates on capital gains may also apply.

## Information reporting and backup withholding

Dividends and payments of the proceeds on a sale of shares or ADS, paid within the US or through certain US-related financial intermediaries, are subject to information reporting and may be subject to backup withholding unless the US holder is a corporation or other exempt recipient or provides a taxpayer identification number and certifies that no loss of exemption has occurred. Non-US holders generally are not subject to information reporting or backup withholding, but may be required to provide a certification of their non-US status in connection with payments received. Any amounts withheld will be allowed as a refund or credit against a holder's US federal income tax liability provided the required information is furnished to the IRS.

## Estate and gift taxes

Under the Estate and Gift Tax Convention, a US shareholder is not generally subject to UK inheritance tax. However, a US holder may be subject to US federal estate and gift tax.

## Stamp duty

UK stamp duty and/or SDRT will, subject to certain exemptions, be payable on any transfer of shares to the ADS custodian or depository at a rate of 1.5% of the amount of any consideration provided (if transferred on sale), or their value (if transferred for no consideration).

However, no stamp duty or SDRT should be payable on the transfer of, or agreement to, transfer an ADS or on transfers within the clearance service. Notwithstanding the above, where the clearance service operator has made an election under s97A Finance Act 1986, broadly the 1.5% stamp duty/SDRT charge should not arise on the transfer into the clearance service, but transfers to, and within, the system (where there is a change in beneficial ownership) would attract a 0.5% charge.

## Demerger and Share Consolidation

A summary of certain UK and US tax consequences in respect of the Demerger and Share Consolidation relevant to the company’s shareholders who are resident (or, in the case of individuals, resident and domiciled) in the UK for UK tax purposes or who are citizens of or resident in the US for US tax purposes is set out in Part 6 of the Circular (pages 83 to 87). The Circular, along with other information regarding the Demerger and Share Consolidation can be found at gsk.com in the demerger section.

Further information on the tax base cost allocation to assist UK shareholders apportion their base cost between their GSK plc shares and Haleon plc shares for UK capital gains tax purposes following the Demerger, including a worked example, can be found in the Tax section at gsk.com in the demerger section.



## Other statutory disclosures

## Shareholder services and contacts

## Registrar

The company’s registrar is:
Equiniti Limited
Aspect House, Spencer Road, Lancing, BN99 6DA
www.shareview.co.uk
Tel: +44 (0)371 384 2991 \( ^{*} \) 

Equiniti provides a range of services for shareholders:

<table><tr><td>Service</td><td>What it offers</td><td>How to participate</td></tr><tr><td>Dividend Reinvestment Plan (DRIP)</td><td>As an alternative to receiving cash dividends you may choose to reinvest your dividends to buy more GSK shares.</td><td>A DRIP election form, Terms and Conditions and information on fees can be downloaded from www.shareview.co.uk or requested by contacting Equiniti.</td></tr><tr><td>Dividend payment direct to your bank account (Bank Mandate)</td><td>All dividends are paid directly into your bank or building society account. To receive your cash dividends, you must provide Equiniti with your bank or building society account details. This is a quick and secure method of payment.</td><td>A dividend bank mandate form can be downloaded from www.shareview.co.uk or requested by contacting Equiniti.</td></tr><tr><td>Dividend payment direct to bank account for overseas shareholders (Overseas Payment Service)</td><td>Equiniti can convert your dividend into your local currency and send it direct to your local bank account. The Overseas Payment Service is available in approximately 100 countries worldwide.</td><td>More information on the Overseas Payment Service (including information on fees) can be found at www.shareview.co.uk or by contacting Equiniti.</td></tr><tr><td>Electronic communications</td><td>Shareholders may elect to receive electronic notifications of company communications including our Annual Report, dividend payments, dividend confirmations and the availability of online voting for all general meetings. Each time GSK publishes shareholder documents you will receive an email containing a link to the document or relevant website.</td><td>Please register at www.shareview.co.uk.</td></tr><tr><td>Shareview portfolio service</td><td>This enables you to create a free online portfolio to view your share balance and movements, update your address and dividend payment instructions and register your votes for our general meetings.</td><td>Please register at www.shareview.co.uk.</td></tr><tr><td>Deduplication of publications or mailings</td><td>If you receive duplicate copies of mailings, you may have more than one account. Please contact Equiniti and they will arrange for your accounts to be merged into one for your convenience and to avoid waste and unnecessary costs.</td><td>Please contact Equiniti.</td></tr><tr><td>Share dealing service \( ^{1} \)  (please note that market trading hours are from 8.00am to 4.30pm UK time, Monday to Friday (excluding public holidays in England and Wales))</td><td>Shareholders may trade shares, either held in certificated form or in our Corporate Sponsored Nominee, online, by telephone or via postal dealing service provided by Equiniti Financial Services Limited.</td><td>More information on the share dealing service (including information on fees) can be found at www.shareview.co.uk/dealing For online transactions, please log on to: www.shareview.co.uk/dealing For telephone transactions, please call: 0345 603 7037 (in the UK) or +44 (0)345 603 7037 (outside the UK). Lines are open from 8.00am to 4.30pm UK time, Monday to Friday (excluding UK public holidays). For postal transactions, please call: 0371 384 2991* to request a dealing form.</td></tr><tr><td>Corporate Sponsored Nominee Account</td><td>This is a convenient way to manage your shares without requiring a share certificate. The service provides a facility for you to hold your shares in a nominee account sponsored by the company. You will continue to receive dividend payments and can attend and vote at the company&#x27;s general meetings. Shareholders&#x27; names do not appear on the publicly available share register and the service is free to join.</td><td>An application form can be requested from www.shareview.co.uk or by contacting Equiniti.</td></tr><tr><td>Individual Savings Accounts (ISAs) \( ^{1} \)</td><td>Equiniti Financial Services Limited provide the EQI Flexible ISA to hold GSK shares.</td><td>Details (including information on fees) are available from www.equi.co.uk or can be requested by calling the Equiniti Customer Experience Team on 0345 0700 720. Lines are open 8.00am to 5.30pm, UK time Monday to Friday (excluding UK public holidays).</td></tr></table>

* Lines are open from 8.30am to 5.30pm, UK time Monday to Friday (excluding public holidays in England and Wales). Please use the country code when dialling from outside the UK.
† The provision of share dealing details is not intended to be an invitation or inducement to engage in an investment activity. Advice on share dealing should be obtained from a stockbroker or independent financial adviser.



## Shareholder information continued

## Shareholders services and contacts continued

## ADS Depositary

The ADR programme is administered by JP Morgan Chase Bank, NA:

Regular Correspondence:
EQ Shareowner Services
P.O. Box 64504
St. Paul, MN 55164-0504

Delivery of Stock Certificates and Overnight Mail:
EQ Shareowner Services
1110 Centre Pointe Curve, Suite 101
Mendota Heights, MN 55120-4100

shareowneronline.com/informational/contact-us/
From the US: +1 877 353 1154
From outside the US: +1 651 453 2128

The Depository also provides Global Invest Direct, a direct ADS purchase/sale and dividend reinvestment plan for ADS holders. For details on how to enrol please visit www.adr.com or call the above helpline number to obtain an enrolment pack.

## Donating shares to Save the Children

In 2013, GSK embarked on an ambitious global partnership with Save the Children to share our expertise and resources with the aim of finding innovative ways to reduce the number of children dying from preventable diseases.

Shareholders with a small number of shares, the value of which makes it uneconomical to sell, may wish to consider donating them to Save the Children. Donated shares will be aggregated and sold on behalf of Save the Children who will use the funds raised to help them reach the above goal. \( ^{1} \) 

To obtain a share donation form, please contact our registrar, Equiniti, which is managing the donation and sale of UK shares to Save the Children free of charge.

The provision of share dealing details is not intended to be an invitation or inducement to engage in an investment activity. Advice on share dealing should be obtained from a stockbroker or independent financial adviser.

## Stock Exchange announcement notifications

We provide shareholders with a service to receive automatic email notifications when we publish a stock exchange announcement. To receive email notifications, please sign up for announcements at gsk.com in the Investors section.

## Contacts

## Investor relations

Investor relations may be contacted as follows:

## UK

980 Great West Road
Brentford, Middlesex, TW8 9GS
Tel: +44 (0)20 8047 5000

## US

2929 Walnut Street
Philadelphia PA 19104
Tel: +1 888 825 5249 (US toll free)
Tel: +1 215 751 4000 (outside the US)

## GSK Response Center

Tel: +1 888 825 5249 (US toll free)
Tel: +1 215 751 4600 (outside the US)

## Share scam alert

If you receive an unsolicited telephone call offering to sell or buy your shares, please take extra care. The caller may be part of a highly organised financial scam.

If you are a UK shareholder, please contact the Financial Conduct Authority at www.fca.org.uk/consumers or on its consumer helpline:

Tel: 0800 111 6768 (in the UK)*

Tel: +44 207 066 1000 (outside the UK)*

* Lines are open from 8:00am to 6:00pm, UK time, Monday to Friday, except UK public holidays, and 9:00am to 10:00pm on Saturdays.



## Other statutory disclosures continued

## US law and regulation

A number of provisions of US law and regulation apply to the company because our shares are quoted on the NYSE in the form of ADS.

## NYSE rules

In general, the NYSE rules permit the company to follow UK corporate governance practices instead of those applied in the US, provided that we explain any significant variations. This explanation is contained in our Form 20-F, which can be accessed from the SEC's EDGAR database or via our website. NYSE rules require us to file annual and interim written affirmations concerning our Audit & Risk Committee (ARC) and our statement on significant differences in corporate governance.

## Sarbanes-Oxley Act of 2002

Following a number of corporate and accounting scandals in the US, Congress passed the Sarbanes-Oxley Act of 2002. Sarbanes-Oxley is a wide-ranging piece of legislation concerned largely with financial reporting and corporate governance.

As recommended by the SEC, the company has an established Disclosure Committee. The Committee reports to the CEO, the CFO and to the ARC. It is chaired by the Company Secretary and its members consist of senior managers from finance, legal, corporate communications and investor relations.

Where appropriate, external legal counsel, the external auditors, our sponsor bank, and internal experts are invited to attend the Disclosure Committee’s meetings periodically. The Committee has responsibility for considering the materiality of information and, on a timely basis, determining the disclosure of that information. It has responsibility for the timely filing of reports with the SEC and the formal review of the Annual Report and Form 20-F. In 2022, the Committee met 28 times, including for the purpose of receiving relevant and appropriate training.

Sarbanes-Oxley requires that the annual report on Form 20-F contains a statement as to whether a member of the ARC is an audit committee financial expert, as defined in rules under Sarbanes-Oxley. Such a statement for the relevant members of the ARC (Charles Bancroft) is included in the Board Committee information area of the Corporate Governance report on page 109 and in his biography on page 98. Additional disclosure requirements arise under section 302 and section 404 of Sarbanes-Oxley in respect of disclosure controls and procedures and internal control over financial reporting.

## Section 302: Corporate responsibility for financial reports

Sarbanes-Oxley requires for the CEO and the CFO to complete formal certifications, confirming that:

– they have each reviewed the annual report on Form 20-F;

– based on their knowledge, the annual report on Form 20-F contains no material misstatements or omissions;

– based on their knowledge, the financial statements and other financial information fairly present, in all material respects, the financial condition, results of operations and cash flows as of the dates, and for the periods, presented in the annual report on Form 20-F;

– they are responsible for establishing and maintaining disclosure controls and procedures that ensure that material information is made known to them, and have evaluated the effectiveness of these controls and procedures as at the year end, the results of such evaluation being contained in the annual report on Form 20-F;

– they are responsible for establishing and maintaining internal control over financial reporting that provides reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles; and

– they have disclosed in the annual report on Form 20-F any changes in internal controls over financial reporting during the period covered by the annual report on Form 20-F that have materially affected, or are reasonably likely to affect materially, the company’s internal control over financial reporting, and they have disclosed, based on their most recent evaluation of internal control over financial reporting, to the external auditor and the ARC, all significant deficiencies and material weaknesses in the design or operation of internal controls over financial reporting which are reasonably likely to affect adversely the company’s ability to record, process, summarise and report financial information, and any fraud (regardless of materiality) involving persons that have a significant role in the company’s internal control over financial reporting.

The Group has carried out an evaluation under the supervision and with the participation of its management, including the CEO and CFO, of the effectiveness of the design and operation of the Group’s disclosure controls and procedures as at 31 December 2022.

There are inherent limitations to the effectiveness of any system of disclosure controls and procedures, including the possibility of human error and the circumvention or overriding of the controls and procedures. Accordingly, even effective disclosure controls and procedures can only provide reasonable assurance of achieving their control objectives.



## Other statutory disclosures continued

## US law and regulation continued

The CEO and CFO expect to complete these certifications and report their conclusions on the effectiveness of disclosure controls and procedures in March 2023, following which the certifications will be filed with the SEC as part of our Group's Form 20-F.

## Section 404: Management’s annual report on internal control over financial reporting

In accordance with the requirements of section 404 of Sarbanes-Oxley, the following report is provided by management in respect of the company’s internal control over financial reporting (as defined in Rules 13a-15(f) and 15d-15(f) under the US Securities Exchange Act of 1934, as amended (the Exchange Act)):

– management is responsible for establishing and maintaining adequate internal control over financial reporting for the Group. Internal control over financial reporting is designed to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with IFRS;

– management conducted an evaluation of the effectiveness of internal control over financial reporting based on the framework, Internal Control – Integrated Framework (2013) issued by the Committee of Sponsoring Organisations of the Treadway Commission (COSO);

– there have been no changes in the Group’s internal control over financial reporting during 2022 that have materially affected, or are reasonably likely to materially affect, the Group’s internal control over financial reporting;

– management has assessed the effectiveness of internal control over financial reporting as at 31 December 2022 and its conclusion will be filed as part of the Group’s Form 20-F; and

– Deloitte LLP, which has audited the consolidated financial statements of the Group for the year ended 31 December 2022, has also assessed the effectiveness of the Group’s internal control over financial reporting under Auditing Standard 2201 of the Public Company Accounting Oversight Board (United States). Their audit report will be filed with the Group’s Form 20-F.

## Section 13(r) of the Exchange Act

Section 13(r) of the Exchange Act requires issuers to make specific disclosure in their annual reports of certain types of dealings with Iran, including transactions or dealings with government-owned or-controlled entities, as well as dealings with entities sanctioned for activities related to terrorism or proliferation of weapons of mass destruction, even when those activities are not prohibited by US law and do not involve US persons.
The Group exports certain pharmaceutical, vaccine and consumer products to Iran, via sales by non-US entities that are not subsidiaries of a US entity, to two privately held Iranian distributors.

The Group does not regularly receive information regarding the identity of its distributors' downstream customers and intermediaries in Iran, and it is possible that these parties include entities, such as government-owned hospitals and pharmacies, that are owned directly or indirectly by the Iranian government or by persons or entities sanctioned in connection with terrorism or proliferation activities.

Because the Group does not regularly receive information regarding the identity of its distributors' downstream customers it cannot establish the proportion of gross revenue or sales potentially attributable to entities affiliated with the Iranian government or parties sanctioned for disclosable activities. As a result, the Group is reporting the entire gross revenues (€8.7 million) and net profits (€3.7 million) from the Group's sales to Iran in 2022.

The Group is also aware that some hospitals or other medical facilities in Lebanon may be affiliated with or controlled by Hezbollah or other groups that are designated by the United States pursuant to Executive Order 13224. Again, the Group does not deal directly with such hospitals or facilities and instead sells through distributors. The Group is unable to establish the proportion of gross revenue or sales potentially attributable to reportable activities. As a result, the Group is reporting the entire gross revenues (€6.3 million) and net losses (€0.2 million) from the Group's sales to Lebanon in 2022.

Unless noted, the Group intends to continue the activities described above.

In addition to Section 13(r) of the Exchange Act, US law generally restricts dealings by US persons and dealings that otherwise are subject to US jurisdiction with certain countries or territories that are subject to comprehensive sanctions, currently Crimea, Cuba, the so-called Donetsk People's Republic, Iran, the so-called Luhansk People's Republic, North Korea and Syria, as well as with the Government of Venezuela (though not with the country of Venezuela as a whole). The Group does business, via non-US entities (which are not owned or controlled by US entities), in certain such jurisdictions. While we believe the Group complies with all applicable US sanctions in all material respects, such laws are complex and continue to evolve rapidly.



## Donations to political organisations and political expenditure

To ensure a consistent approach to political contributions across the Group, in 2009 a global policy was introduced to voluntarily stop all corporate political contributions.

In the period from 1 January 2009 to 31 December 2022, the Group did not make any political donations to EU or non-EU organisations.

Notwithstanding the introduction of this policy, in accordance with the Federal Election Campaign Act in the US, we continue to support an employee-operated Political Action Committee (PAC) that facilitates voluntary political donations by eligible GSK employees.

The PAC is not controlled by GSK. Decisions on the amounts and recipients of contributions are governed by the PAC Board of Directors. Contributions to the PAC are made by participating eligible employees exercising their legal right to pool their resources and make political contributions, which are subject to strict limitations under US law. In 2022, a total of US$360,950 (2021: US$298,000) was donated to political organisations by the GSK employee PAC.

English law requires prior shareholder approval for political contributions to EU political parties and independent election candidates as well as for any EU political expenditure. The definitions of political donations, political expenditure and political organisations used in the legislation are, however, quite broad. In particular, the definition of EU political organisations may extend to bodies such as those concerned with policy review, law reform, the representation of the business community and special interest groups such as those concerned with the environment, which the company and its subsidiaries might wish to support.
As a result, the definitions may cover legitimate business activities not in the ordinary sense considered to be political donations or political expenditure, nor are they designed to support any political party or independent election candidate.

Therefore, notwithstanding our policy, and while we do not intend to make donations to any EU political parties or organisations, nor to incur any EU political expenditure, we annually seek shareholder authorisation for any inadvertent expenditure.

The authority is a precautionary measure to ensure that the company and its subsidiaries do not inadvertently breach the legislation.

This authorisation process, for expenditure of up to £100,000 each year, dates back to the AGM held in May 2001, following the introduction of the Political Parties, Elections and Referendums Act 2000. The authority has since been renewed annually.



## Other statutory disclosures continued

## Group companies

In accordance with Section 409 of the Companies Act 2006 a full list of subsidiaries, associates, joint ventures and joint arrangements, the address of the registered office and effective percentage of equity owned, as at 31 December 2022 are disclosed below. Unless otherwise stated the share capital disclosed comprises ordinary shares which are indirectly held by GSK plc. The percentage held by class of share is stated where this is less than 100%. Unless otherwise stated, all subsidiary companies have their registered office and are tax resident in their country of incorporation.

<table><tr><td>Name</td><td>Security</td><td>Registered address</td></tr><tr><td colspan="3">Wholly owned subsidiaries</td></tr><tr><td>1506369 Alberta ULC</td><td>Common</td><td>3500 855-2nd Street SW, Calgary AB T2P 4J8, Canada</td></tr><tr><td>Action Potential Venture Capital Limited</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>Adechsa GmbH (ii)</td><td>Ordinary</td><td>c/o PRV Provides Treuhandgesellschaft AG, Dorfstrasse 38, 6341, Baar, Switzerland</td></tr><tr><td>Affinvex Securities Corporation</td><td>Common</td><td>c/o Affinvex, Inc., 301 Binney Street, Cambridge MA 02142, United States</td></tr><tr><td>Affinvex, Inc.</td><td>Common</td><td>Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808, United States</td></tr><tr><td>Allen &amp; Hanburys Limited (ii)</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>Allen &amp; Hanburys Pharmaceutical Nigeria Limited</td><td>Ordinary</td><td>49, Town Planning Way, Lupjeju, Lagos, Nigeria</td></tr><tr><td>Allen Pharmazeutika Gesellschaft m.b.H.</td><td>Ordinary</td><td>Wienerbergstraße 7, Wien, 1100, Austria, Austria</td></tr><tr><td>BEECHAM GROUP p.l.c</td><td>5p Ordinary B; 20p Ordinary A</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>Beecham Pharmaceuticals (Pte) Limited</td><td>Ordinary</td><td>38 Quality Road, Jurong Industrial Estate, Jurong, 618809, Singapore</td></tr><tr><td>Beecham Portuguesa-Produtos Farmaceuticos e Quimicos, Lda, Quota</td><td>Ordinary</td><td>Rua Dr Antonio Loureiro Borges No 3, Arquiparque, Miraflores, 1495-131, Alges, Portugal</td></tr><tr><td>Beecham S.A.</td><td>Ordinary</td><td>Avenue Fleming 20, 1300 Wavre, Belgium</td></tr><tr><td>Biovesta Ilaçları Ltd. Sti. (ii)</td><td>Nominative</td><td>Büyükdere Caddesi No. 173, Level Plaza B Blok, I.Levent, Istanbul, 34394, Turkey</td></tr><tr><td>Cascan GmbH &amp; Co. KG</td><td>Partnership Capital</td><td>Prinzregentenplatz 9, 81675, Munich, Germany</td></tr><tr><td>Cellzone GmbH</td><td>Ordinary</td><td>Meyerhofstrasse 1, 69117, Heidelberg, Germany</td></tr><tr><td>Cellzone Limited (in liquidation)</td><td>Ordinary</td><td>c/o BDO LLP, 5 Temple Square, Temple Street, Liverpool, L2 5RH, United Kingdom</td></tr><tr><td>Charles Midgley Limited (in liquidation)</td><td>Ordinary</td><td>c/o BDO LLP, 5 Temple Square, Temple Street, Liverpool, L2 5RH, United Kingdom</td></tr><tr><td>Clarges Pharmaceuticals Limited (in liquidation)</td><td>Ordinary; Preference</td><td>c/o BDO LLP, 5 Temple Square, Temple Street, Liverpool, L2 5RH, United Kingdom</td></tr><tr><td>Clarges Pharmaceutical Trustees Limited (ii) (iv)</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>Colleen Corporation</td><td>Common</td><td>Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808, United States</td></tr><tr><td>Corixa Corporation</td><td>Common</td><td>Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808, United States</td></tr><tr><td>Dealcyber Limited</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>Desarrollo Energía Solar Alternativa S.L.</td><td>Ordinary</td><td>Severo Ochoa, 2, Parque Tecnológico de Madrid, Tres Cantos, 28760, Madrid, Spain</td></tr><tr><td>Duncan Pharmaceuticals Philippines Inc.</td><td>Common</td><td>23rd Floor, The Finance Centre, 26th Street Corner 9th Avenue, Bonifacio Global City, Taguig City, 1634, Philippines</td></tr><tr><td>Etex Farmaceutica Ltda</td><td>Social Capital</td><td>Av. Andrés Bello 2457, Costanera Center, Torre 2, Piso 20, Providencia, Santiago, 7510689, Chile</td></tr><tr><td>Genelabs Technologies, Inc.</td><td>Common</td><td>Corporation Service Company, 2710 Gateway Oaks Drive, Suite 150N, Sacramento CA 95833, United States</td></tr><tr><td>Glaxo Group Limited</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>Glaxo Kabushiki Kaisha (ii)</td><td>Ordinary</td><td>1-8-1 Akasaka Minato-ku, Tokyo, Japan</td></tr><tr><td>Glaxo Laboratories (Nigeria) Limited (ii)</td><td>Ordinary</td><td>82 Marine Road, Apapa, Lagos, Nigeria</td></tr><tr><td>Glaxo Laboratories Limited (In Liquidation)</td><td>Ordinary</td><td>55 Baker Street, London, WIU 7EU, United Kingdom</td></tr><tr><td>Glaxo New Zealand Pension Plan Trustee Limited</td><td>Ordinary</td><td>Level 2 E.2, Generator at GridAKL, 12 Madden Street, Wynyard Quarter, Auckland, 1010, New Zealand</td></tr><tr><td>Glaxo Operations UK Limited</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>Glaxo Properties BV</td><td>Ordinary</td><td>Van Asch van Wijckstraat 55h, 3811 LP, Amersfoort, Netherlands</td></tr><tr><td>Glaxo Trustees Limited (in liquidation)</td><td>Ordinary</td><td>55 Baker Street, London, WIU 7EU, United Kingdom</td></tr><tr><td>Glaxo Verwaltungs GmbH</td><td>Ordinary</td><td>Prinzregentenplatz 9, 81675, Munich, Germany</td></tr><tr><td>Glaxo Wellcome Farmaceutica, Limitada</td><td>Ordinary Quota</td><td>Rua Dr Antonio Loureiro Borges No 3, Arquiparque, Miraflores, 1495-131, Alges, Portugal</td></tr><tr><td>Glaxo Wellcome Manufacturing Pte Ltd</td><td>Ordinary</td><td>1 Pioneer Sector 1, Jurong Industrial Estate, Jurong, 628413, Singapore</td></tr><tr><td>Glaxo Wellcome Production</td><td>Ordinary</td><td>23 rue François Jacob, 92500, Rueil-Malmaison, France</td></tr><tr><td>Glaxo Wellcome Vidyasom Limited (ii)</td><td>Ordinary</td><td>12th Floor Wave Place, 55 Wireless Road, Lumpini, Pathumwan, Bangkok, 10330, Thailand</td></tr></table>



## Other statutory disclosures continued

Group companies continued

<table><tr><td>Name</td><td>Security</td><td>Registered address</td></tr><tr><td colspan="3">Wholly owned subsidiaries continued</td></tr><tr><td>Glaxo Wellcome, S.A.</td><td>Ordinary</td><td>Poligono Industrial Allendeduero, Avenida de Extremadura, 3, Aranda de Duero, 09400, Burgos, Spain</td></tr><tr><td>Glaxo, S.A.</td><td>Ordinary</td><td>Severo Ochoa, 2, Parque Tecnologico de Madrid, Tres Cantos, 28760, Madrid, Spain</td></tr><tr><td>Glaxo-Allenburys (Nigeria) Limited (ii)</td><td>Ordinary</td><td>41 Creek Road, Apapa, Lagos, PMB 1401, Nigeria</td></tr><tr><td>Glaxochem Pte Ltd (iii)</td><td>Ordinary</td><td>23 Rochester Park, 139234, Singapore</td></tr><tr><td>GlaxoSmithKline - Produtos Farmaceuticos, Limitada</td><td>Ordinary Quota</td><td>Rua Dr Antonio Loureiro Borges No 3, Arquiparque, Miraflores, 1495-131, Alges, Portugal</td></tr><tr><td>GlaxoSmithKline (Cambodia) Co., Ltd.</td><td>Ordinary</td><td>5th Floor DKSH Building, No.797 Preah Monivong Boulevard (Co, Sangkat Phsar Deum Thakow, Khan Chamkarmon, Phnom Penh, Cambodia</td></tr><tr><td>GlaxoSmithKline (China) Investment Co Ltd</td><td>Ordinary</td><td>Room 901, 902, 903, 905, 908, 909 and 910, Unit 901, Floor 9, No. 56 Mid 4th East Ring Road, Chaoyang District, Beijing, China</td></tr><tr><td>GlaxoSmithKline (China) R&amp;D Company Limited</td><td>Equity</td><td>F1-3, No.18 Building, 999 Huanke Road, Pilot Free Trade Zone, Shanghai, 201210, China</td></tr><tr><td>GlaxoSmithKline (GSK) S.R.L.</td><td>Ordinary</td><td>1-5 Costache Negri Street, Opera Center One, 5th and 6th floors, Zone 1, District 5, Bucharest, Romania</td></tr><tr><td>GlaxoSmithKline (Ireland) Limited</td><td>Ordinary</td><td>12 Riverwalk, Citywest Business Campus, Dublin 24, Ireland</td></tr><tr><td>GlaxoSmithKline (Israel) Ltd</td><td>Ordinary</td><td>25 Basel Street, PO Box 10283, Petach-Tikva, 49002, Israel</td></tr><tr><td>GlaxoSmithKline (Malta) Limited</td><td>Ordinary</td><td>1, First Floor, De La Cruz Avenue, Qormi, QRM2458, Malta</td></tr><tr><td>GlaxoSmithKline (Private) Limited (ii)</td><td>Ordinary</td><td>Unit 3, 20 Anthony Road, Msasa, Harare, Zimbabwe</td></tr><tr><td>GlaxoSmithKline (Thailand) Limited</td><td>Ordinary</td><td>12th Floor Wave Place, 55 Wireless Road, Lumpini, Pathumwan, Bangkok, 10330, Thailand</td></tr><tr><td>GlaxoSmithKline AB</td><td>Ordinary</td><td>Hemvarnsg, 9, 171 54, Solna, Sweden</td></tr><tr><td>GlaxoSmithKline AG</td><td>Ordinary</td><td>Talstrasse 3-5, 3053 Muenchenbuchsee, Switzerland</td></tr><tr><td>GlaxoSmithKline Angola Unipessoal Limitada</td><td>Quota</td><td>Luanda, Bairro Petrangol, Estrada de Cacuaco n° 288, Angola</td></tr><tr><td>GlaxoSmithKline Argentina S.A.</td><td>Ordinary</td><td>Tucumán 1, piso 4, Buenos Aires, C1049AAA, Argentina</td></tr><tr><td>GlaxoSmithKline AS</td><td>Ordinary</td><td>Drammensveien 288, Oslo, NO-0283, Norway</td></tr><tr><td>GlaxoSmithKline Australia Pty Ltd</td><td>Ordinary</td><td>1061 Mountain Highway, Boronia Victoria VIC 3155, Australia</td></tr><tr><td>GlaxoSmithKline BV.</td><td>Ordinary</td><td>Van Asch van, Wijckstraat 55h, 3811 LP Amersfoort, The Netherlands, Netherlands</td></tr><tr><td>GlaxoSmithKline Beteiligungs GmbH</td><td>Ordinary</td><td>Prinzregentenplatz 9, 81675, Munchen, Germany</td></tr><tr><td>GlaxoSmithKline Biologicals Kft.</td><td>Ordinary</td><td>2100 Gödöllő, Homoki Nagy István utca 1, Hungary</td></tr><tr><td>GlaxoSmithKline Biologicals S.A.S.</td><td>Ordinary</td><td>637 Rue des Aulnois, Saint-Amand Les Eaux, 59230, France</td></tr><tr><td>GlaxoSmithKline Biologicals SA</td><td>Ordinary; Preference</td><td>Rue de l&#x27;Institut 89 B-1330 Rixensart, Belgium</td></tr><tr><td>GlaxoSmithKline Brasil Limitada</td><td>Quotas</td><td>Estrada dos Banderiantes, 8464, Rio de Janeiro, 22783-110, Brazil</td></tr><tr><td>GlaxoSmithKline Capital Inc.</td><td>Common</td><td>Wilmington Trust SP Services, Inc., 1100 N. Market Street, 4th Floor, Wilmington DE 19890, United States</td></tr><tr><td>GlaxoSmithKline Capital plc</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>GlaxoSmithKline Caribbean Limited</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>GlaxoSmithKline Chile Ferrocarrilca Limitada</td><td>Social Capital</td><td>Av. Andrés Bello 2457, Torre 2, piso 20, Providencia, Santiago, Región Metropolitana, Chile</td></tr><tr><td>GlaxoSmithKline Colombia S.A.</td><td>Ordinary</td><td>Avenida El Dorado, #69B-45/Piso 9, Bogotá, Colombia</td></tr><tr><td>GlaxoSmithKline Consumer Holding B.V. (ii)</td><td>Ordinary</td><td>Van Asch van Wijckstraat 55h, 3811 LP, Amersfoort, Netherlands</td></tr><tr><td>GlaxoSmithKline do.o Sarajevo - u likvidaciji (In Liquidation)</td><td>Quotas</td><td>Zmja od Bosne broj 7-7a, Sarajevo, 71000, Bosnia and Herzegovina</td></tr><tr><td>GlaxoSmithKline do.o.</td><td>Equity Capital</td><td>Ulica Damira Tomljanovica Gavrana 15, Zagreb, Croatia</td></tr><tr><td>GlaxoSmithKline doo Beograd-Novi Beograd - U LIKVIDACIJI (In liquidation)</td><td>Ordinary</td><td>Milutin Milankovic, I.J. Novi Beograd, Belgrade, 11070, Serbia</td></tr><tr><td>GlaxoSmithKline Ecuador S.A.</td><td>Ordinary</td><td>Av 10 De Agosto N36-239, y Naciones Unidas, Edificio Electroectuatoriana, 2do piso, Quito, Ecuador</td></tr><tr><td>GlaxoSmithKline El Salvador S.A. de C.V.</td><td>Ordinary</td><td>Municipio de San Salvador, Departamento de San Salvador, El Salvador</td></tr><tr><td>GlaxoSmithKline EOOD</td><td>Ordinary</td><td>16 Nedelcho Bonchev str., Sofia, 1592, Bulgaria</td></tr><tr><td>GlaxoSmithKline Export Limited</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>GlaxoSmithKline Export Panama S.A.</td><td>Ordinary</td><td>Panama City, Republic of Panama, Panama</td></tr><tr><td>GlaxoSmithKline Far East B.V.</td><td>Ordinary</td><td>Van Asch van Wijckstraat 55h, 3811 LP, Amersfoort, Netherlands</td></tr><tr><td>GlaxoSmithKline Finance plc</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>GlaxoSmithKline GmbH &amp; Co. KG</td><td>Partnership Capital</td><td>Prinzregentenplatz 9, 81675, Munchen, Germany</td></tr><tr><td>GlaxoSmithKline Guatemala S.A.</td><td>Ordinary</td><td>3ra. Av. 13-78 Zona 10, Torre Citibank, Nivel 8, Guatemala City, Guatemala</td></tr><tr><td>GlaxoSmithKline Holding AS</td><td>Ordinary</td><td>Drammensveien 288, Oslo, NO-0283, Norway</td></tr><tr><td>GlaxoSmithKline Holdings (Americas) Inc.</td><td>Common</td><td>Wilmington Trust SP Services Inc., 1100 North Market Street, 4th Floor, Wilmington, Delaware, 19890</td></tr><tr><td>GlaxoSmithKline Holdings (One) Limited (i)</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>GlaxoSmithKline Holdings Limited (i)</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr></table>



## Other statutory disclosures continued

<table><tr><td>Name</td><td>Security</td><td>Registered address</td></tr><tr><td colspan="3">Wholly owned subsidiaries continued</td></tr><tr><td>GlaxoSmithKline Holdings Pty Ltd</td><td>Ordinary</td><td>1061 Mountain Highway, Boronia Victoria VIC 3155, Australia</td></tr><tr><td>GlaxoSmithKline Honduras S.A.</td><td>Ordinary</td><td>Tegucigalpa, MDC, Honduras</td></tr><tr><td>GlaxoSmithKline IHC Limited</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>GlaxoSmithKline Ilaelari Sanayi ve Ticaret A.S.</td><td>Nominative</td><td>Büyükdere Caddesi No. 173, Level Plaza B Blok, Level, Istanbul, 34394, Turkey</td></tr><tr><td>GlaxoSmithKline Inc.</td><td>Class A Common; Class C Preference</td><td>100 Milverton Drive, Suite 800, Mississauga ON L5R 4H1, Canada</td></tr><tr><td>GlaxoSmithKline Insurance Ltd.</td><td>Ordinary</td><td>c/o Trinity Corporate Services Ltd., Trinity Hall, 43 Cedar Avenue, Hamilton, Hamilton, HM12, Bermuda</td></tr><tr><td>GlaxoSmithKline Intellectual Property (No.2) Limited</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>GlaxoSmithKline Intellectual Property Development Limited</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>GlaxoSmithKline Intellectual Property Holdings Limited</td><td>A Ordinary; B Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>GlaxoSmithKline Intellectual Property Limited</td><td>Deferred; Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>GlaxoSmithKline Intellectual Property Management Limited</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>GlaxoSmithKline Investigación y Desarrollo, S.L.</td><td>Ordinary</td><td>Severo Ochoa 2 Parque Tecnológico de Madrid, Tres Cantos, 28760, Madrid, Spain</td></tr><tr><td>GlaxoSmithKline Investments Pty Ltd</td><td>Ordinary</td><td>1061 Mountain Highway, Boronia Victoria VIC 3155, Australia</td></tr><tr><td>GlaxoSmithKline K.K.</td><td>Ordinary</td><td>1-8-1 Akasaka Minato-ku, Tokyo, Japan</td></tr><tr><td>GlaxoSmithKline Korea Limited</td><td>Ordinary</td><td>9F LS Yongsan Tower, 92 Hangang-daero, Yongsan-gu, Seoul, 04386, Korea, Republic of</td></tr><tr><td>GlaxoSmithKline Latin America, S.A.</td><td>Ordinary</td><td>Panama City, Republic of Panama, Panama</td></tr><tr><td>GlaxoSmithKline Lietuva UAB</td><td>Ordinary</td><td>Ukmerges st. 120, Vilnius, LT-08105, Lithuania</td></tr><tr><td>GlaxoSmithKline Limited</td><td>Ordinary</td><td>23/F., Tower 6, The Gateway, 9 Canton Road, Tsimshatsui, Kowloon, Hong Kong</td></tr><tr><td>GlaxoSmithKline Limited (i)</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>GlaxoSmithKline LLC</td><td>LLC Interests</td><td>Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808, United States</td></tr><tr><td>GlaxoSmithKline Manufacturing SpA</td><td>Ordinary</td><td>Viale dell&#x27;Agricoltura 7, 37135, Verona, Italy</td></tr><tr><td>GlaxoSmithKline Maroc S.A.</td><td>Ordinary</td><td>42-44 Angle Bd, Rachidi et Abou Hamed El Glaza, Casablanca, Morocco</td></tr><tr><td>GlaxoSmithKline Medical and Healthcare Products Limited</td><td>Ordinary</td><td>H-1124, Csorsz utca 43, Budapest, Hungary</td></tr><tr><td>GlaxoSmithKline Mercury Limited (i)</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>GlaxoSmithKline Mexico S.A. de C.V.</td><td>Ordinary A; Ordinary B</td><td>Av. Real Mayorazgo 130 Piso 20, Colonia Xoco, Alcaldia Benito Juárez, Ciudad de Mexico, 03330, Mexico</td></tr><tr><td>GlaxoSmithKline NZ Limited</td><td>Ordinary</td><td>Level 2 E.2, Generator @GridALK, 12 Madden Street, Wynyard Quarter, Auckland, 1010, New Zealand</td></tr><tr><td>GlaxoSmithKline Oy</td><td>Ordinary</td><td>Pispansilta 9A, PO. Box 24, Espoo, FIN-02230, Finland</td></tr><tr><td>GlaxoSmithKline Peru S.A.</td><td>Ordinary</td><td>Av. Víctor Andrés Belaúnde N°147, Vía Principal N°133, Piso 7, Distrito de San Isidro, Lima, Lima, Perú</td></tr><tr><td>GlaxoSmithKline Pharma A/S</td><td>Ordinary</td><td>Vallensbøk Company House III, Delta Park 37 DK-2665 Valle, Denmark</td></tr><tr><td>GlaxoSmithKline Pharma GmbH</td><td>Ordinary</td><td>Wienerbergerstraße 7, Wien, 1100, Austria, Austria</td></tr><tr><td>GlaxoSmithKline Pharmaceutical Kenya Limited</td><td>Ordinary</td><td>Likoni Road, Nairobi, 78392 - 00507, Kenya</td></tr><tr><td>GlaxoSmithKline Pharmaceutical Nigeria Limited</td><td>Ordinary</td><td>1 Industrial Avenue, Ilupejui, Ijeja, Lagos, PM B 21218, Nigeria</td></tr><tr><td>GlaxoSmithKline Pharmaceutical Sdn Bhd</td><td>Ordinary</td><td>HZ.01, Horizon Penthouse, 1 Powerhouse, 1, Persiaran Bandar Utama, Bandar Utama, 47800 Petaling Jaya, Selangor, Malaysia</td></tr><tr><td>GlaxoSmithKline Pharmaceuticals (Pvt) Ltd</td><td>Ordinary</td><td>121 Galle Road, Kaldemulla, Moratuwa, Sri Lanka</td></tr><tr><td>GlaxoSmithKline Pharmaceuticals Costa Rica S.A</td><td>Ordinary</td><td>Autopista Florencia del Castillo, kilómetro siete, Oficentro TerraCampus, edificio uno, cuarto piso, San Diego, Cartago, 30302, Costa Rica</td></tr><tr><td>GlaxoSmithKline Pharmaceuticals SA</td><td>Ordinary</td><td>Site Apollo, Avenue Pascal 2-4-6, Wavre, 1300, Belgium</td></tr><tr><td>GlaxoSmithKline Pharmaceuticals Ukraine LLC</td><td>Chartered Capital</td><td>Pavla Tychyny avenue, 1-V, Kiev, 02152, Ukraine</td></tr><tr><td>GlaxoSmithKline Philippines Inc</td><td>Ordinary</td><td>23rd Floor, The Finance Centre, 26th Street Corner 9th Avenue, Bonifacio Global City, Taguig City, 1634, Philippines</td></tr><tr><td>GlaxoSmithKline Pte Ltd</td><td>Ordinary</td><td>23 Rochester Park, 139234, Singapore</td></tr><tr><td>GlaxoSmithKline Puerto Rico, Inc.</td><td>Common</td><td>Corporation Service Company Puerto Rico Inc., c/o RVM Professional Services, LLC, A4 Reparto Mendoza, Humacao, 00791, Puerto Rico</td></tr><tr><td>GlaxoSmithKline Republica Dominicana S.A.</td><td>Ordinary</td><td>Blue Mall Tower, Floor 23 Ave, Winston Churchill 95, Santo Domingo, Dominican Republic</td></tr><tr><td>GlaxoSmithKline Research &amp; Development Limited</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>GlaxoSmithKline S.A.</td><td>Ordinary</td><td>Severo Ochoa, 2, Parque Tecnológico de Madrid, Tres Cantos, 28760, Madrid, Spain</td></tr><tr><td>GlaxoSmithKline Sp.A.</td><td>Ordinary</td><td>Viale dell&#x27;Agricoltura 7, 37135, Verona, Italy</td></tr><tr><td>GlaxoSmithKline s.r.o.</td><td>Ordinary</td><td>Hvezdova 1734/2c, Prague, 4 140 00, Czech Republic</td></tr><tr><td>GlaxoSmithKline Services GmbH &amp; Co. KG</td><td>Partnership Capital</td><td>Prinzregentenplatz 9, 81675, Munchen, Germany</td></tr></table>



## Other statutory disclosures continued

Group companies continued

<table><tr><td>Name</td><td>Security</td><td>Registered address</td></tr><tr><td colspan="3">Wholly owned subsidiaries continued</td></tr><tr><td>GlaxoSmithKline Services Unlimited (i)</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>GlaxoSmithKline Single Member A.E.B.E.</td><td>Ordinary</td><td>266 Kifissias Avenue, Halandri, Athens, 152 32, Greece</td></tr><tr><td>GlaxoSmithKline SL LLC</td><td>LLC Interests</td><td>Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808, United States</td></tr><tr><td>GlaxoSmithKline SL LP (ii) (viii)</td><td>Partnership</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>GlaxoSmithKline Slovakia s.r.o. v likvidácii (In Liquidation)</td><td>Ordinary</td><td>KPMG Slovensko Advisory k.s., Dvořákovo nábrežie 10, 811 02 Bratislava, Slovakia</td></tr><tr><td>GlaxoSmithKline South Africa (Pty) Limited</td><td>Ordinary</td><td>Flushing Meadows Building, The Campus, 57 Sloane Street, Bryanston 2021, South Africa</td></tr><tr><td>GlaxoSmithKline Trading Services Limited (iii)</td><td>Ordinary</td><td>12 Riverwalk, Citywest Business Campus, Dublin 24, Ireland</td></tr><tr><td>GlaxoSmithKline Tunisia S.A.R.L.</td><td>Ordinary</td><td>Immeuble REGUS, Lot B17, Centre Urbain Nord, Tunis, Tunisia</td></tr><tr><td>GlaxoSmithKline UK Limited</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>GlaxoSmithKline Uruguay S.A.</td><td>Registered Provisory Stock</td><td>Salto 1105, CP 11200 Montevideo, Uruguay</td></tr><tr><td>GlaxoSmithKline US Trading Limited</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>GlaxoSmithKline Venezuela C.A.</td><td>Ordinary</td><td>Calle Altagracia, edificio P&amp;G, piso Mezzanina, torre Torre Sur, Urbanizacion Sorokaima, La Trinidad, Caracas, 1080, Venezuela, Bolivarian Republic of</td></tr><tr><td>GlaxoSmithKline Vietnam Limited Liability Company (ii)</td><td>Equity Capital</td><td>The Metropolitan, 235 Dong Khoi Street, District 1, 7th Floor Unit 701, Ho Chi Minh City, Vietnam</td></tr><tr><td>GlycoVaxyn AG</td><td>Common; Preferred A; Preferred B; Preferred C</td><td>Grabenstrasse 3, 8952 Schlieren, Switzerland</td></tr><tr><td>Groupe GlaxoSmithKline</td><td>Ordinary</td><td>23 rue François Jacob, 92500, Rueil-Malmaison, France</td></tr><tr><td>GSK (No.3) Scottish Limited Partnership (x)</td><td>Partnership</td><td>50 Lothian Road, Festival Square, Edinburgh, Scotland, EH3 9WJ, United Kingdom</td></tr><tr><td>GSK Biopharma Argentina S.A.</td><td>Nominative Non Endorseable Ordinary</td><td>Tucumán 1, piso 4, Buenos Aires, C1049AAA, Argentina</td></tr><tr><td>GSK Business Service Centre Sdn Bhd</td><td>Ordinary</td><td>Level 6, Quill 9, 112 Jalan Prof. Khoo Kay Kim, Petaling Jaya, 46300 Selangor, Malaysia</td></tr><tr><td>GSK Capital K.K.</td><td>Ordinary</td><td>1-8-1 Akasaka Minato-ku, Tokyo, Japan</td></tr><tr><td>GSK Commercial Sp. z o.o.</td><td>Ordinary</td><td>ul. Rzymowskiego 53, 02-697, Warsaw, Poland</td></tr><tr><td>GSK d.o.o., Ljubljana</td><td>Ordinary</td><td>Ameriška ulica 8., Ljubljana, 1000, Slovenia</td></tr><tr><td>GSK Enterprise Management Co, Ltd</td><td>Ordinary</td><td>Floor 4, 18 Lane 999 Huanke Road, No. 1358 Zhongke Road, Shanghai, China</td></tr><tr><td>GSK Equity Investments, Limited</td><td>Units</td><td>Corporation Service Company, 2595 Interstate Drive, Suite 103, Harrisburg PA 17110, United States</td></tr><tr><td>GSK Finance (No 2) Limited</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>GSK Finance (No 3) plc</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>GSK India Global Services Private Limited</td><td>Equity</td><td>Level 1, 2 &amp; 3 Luxor North Tower, Bagmame Capital Business Park Outer Ring Road, Bangalore, Karnataka, 560037, India</td></tr><tr><td>GSK International Holding and Finance BV</td><td>Ordinary</td><td>Van Asch van Wijckstraat 55h, 3811 LP, Amersfoort, Netherlands</td></tr><tr><td>GSK Kazakhstan LLP</td><td>Participation interest</td><td>273, Furmanov Street, Almaty, Medeu District, 050059, Kazakhstan</td></tr><tr><td>GSK Pharma India Private Limited</td><td>Equity</td><td>1, Battery House, Bhulabhai Desai Road, Mumbai, Maharashtra, 400026, India</td></tr><tr><td>GSK Pharma Vietnam Company Limited</td><td>Chartered Capital</td><td>Unit 702/703 7th Floor, The Metropolitan Tower, 235 Dong Khoi Street, Ben Nghe Ward, District 1, Ho Chi Minh, Vietnam</td></tr><tr><td>GSK Pharmaceutical Trading S.A. (ii)</td><td>Ordinary</td><td>Bucharest, 1-5 Costache Negri Street, Opera Center One, 5th floor, discussions room 01, District 5, Romania</td></tr><tr><td>GSK PSC Poland sp. z o.o.</td><td>Equal and indivisible shares</td><td>ul. Grunwaldzka 189, Poznań, 60-322, Pol</td></tr><tr><td>GSK Services Sp z o.o.</td><td>Ordinary</td><td>Ul. Grunwaldzka 189, 60-322, Poznan, Poland</td></tr><tr><td>GSK Vaccines BV</td><td>Ordinary</td><td>Hullenbergweg 85, 1101 CL, Amsterdam, Netherlands</td></tr><tr><td>GSK Vaccines GmbH</td><td>Ordinary</td><td>Emil-von-Behring-Str.76, 35041 Marburg, Germany</td></tr><tr><td>GSK Vaccines Institute for Global Health Sr.l.</td><td>Quotas</td><td>Via Fiorentina 1, 53100, Siena, Italy</td></tr><tr><td>GSK Vaccines Sr.l.</td><td>Quotas</td><td>Via Fiorentina 1, 53100, Siena, Italy</td></tr><tr><td>GSK Vaccines Vertriebs GmbH</td><td>Ordinary</td><td>Rudolf-Diesel-Ring 27, 83607, Holzkirchen, Germany</td></tr><tr><td>Human Genome Sciences, Inc.</td><td>Common</td><td>Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808, United States</td></tr><tr><td>ID Biomedical Corporation of Quebec</td><td>Common</td><td>2323, boul. Du Parc Technologique, Québec Québec G1P 4R8, Canada</td></tr><tr><td>Instituto Luso Farmaco, Limitada (i)</td><td>Quotas</td><td>Rua Dr Antonio Loureiro Borges No 3, Arquiparque, Miraflores, 1495-131, Alges, Portugal</td></tr><tr><td>InterPharma Dienstleistungen GmbH (i)</td><td>Quotas</td><td>Wienerbergstraße 7, Wien, 1100, Austria, Austria</td></tr><tr><td>J&amp;J Technologies, LC (ii)</td><td>LLC Interests</td><td>Corporation Service Company, 100 Shockoe Slip, 2nd Floor, Richmond VA 23219, United States</td></tr><tr><td>JSC GlaxoSmithKline Trading</td><td>Ordinary</td><td>Leningradskiy Prospect 37A, Building 4, Floor 3, Premises XV, Room 1, 125167, Moscow, Russian Federation</td></tr></table>



## Other statutory disclosures continued

<table><tr><td>Name</td><td>Security</td><td>Registered address</td></tr><tr><td colspan="3">Wholly owned subsidiaries continued</td></tr><tr><td>Laboratoire GlaxoSmithKline</td><td>Ordinary</td><td>23 rue François Jacob, 92500, Rueil-Malmaison, France</td></tr><tr><td>Laboratoire Pharmaceutique Algérien LPA Production SPA</td><td>Ordinary</td><td>Zone Industrielle Est, Boudouaou, Boumerdes, Algeria</td></tr><tr><td>Laboratoire Pharmaceutique Algérien SPA</td><td>Ordinary</td><td>Zone Industrielle Est, Boudouaou, Boumerdes, Algeria</td></tr><tr><td>Laboratoires Paucourt (ii)</td><td>Ordinary</td><td>23 rue François Jacob, 92500, Rueil-Malmaison, France</td></tr><tr><td>Laboratoires Saint-Germain (ii)</td><td>Ordinary</td><td>23 rue François Jacob, 92500, Rueil-Malmaison, France</td></tr><tr><td>Laboratorios Dermatologicos Darier, S.A de C.V.</td><td>Ordinary A; Ordinary B</td><td>Av. Real Mayorazgo 130 Piso 20, Colonia Xoco, Alcaldia Benito Juárez, Ciudad de Mexico, 03330, Mexico</td></tr><tr><td>Laboratorios Farmaceuticos Stiefel (Portugal) LTDA (ii)</td><td>Ordinary</td><td>Rua Dr Antonio Loureiro Borges No 3, Arquiparque, Miraflores, 1495-131, Alges, Portugal</td></tr><tr><td>Laboratorios Stiefel de Venezuela SA</td><td>Ordinary</td><td>Calle Altagracia, Edificio P&amp;G, Nivel Mezzanina, Piso Mezzanina, local Torre Sur, Urbanizacion Sorokaima, La Trinidad, Caracas, 1080, Venezuela, Bolivarian Republic of</td></tr><tr><td>Laboratorios Stiefel Ltda.</td><td>Ordinary</td><td>Rua Professor Joao Cavalheiro Salem, no.1077, Bairro de Bonsucesso, Municipality of Guarulhos, Sao Paulo, CEP 07243-580, Brazil</td></tr><tr><td>Laboratorios Wellcome De Portugal Limitada (ii)</td><td>Quotas</td><td>Rua Dr Antonio Loureiro Borges No 3, Arquiparque, Miraflores, 1495-131, Alges, Portugal</td></tr><tr><td>Montrose Pharma Company Limited (ii)</td><td>Ordinary Quota</td><td>H-1124, Csorsz utca 43, Budapest, Hungary</td></tr><tr><td>PT Glaxo Wellcome Indonesia</td><td>Class A; Class B</td><td>JL Pulobuaran Raya Kavill/DD 2,3,4 KWS. Industri, Pulogadung, Jatinegara, Cakung, Jakarta Timur, Indonesia</td></tr><tr><td>Setfirst Limited</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>Sierra Oncology Australia Pty Ltd</td><td>Ordinary</td><td>c/o Maddocks Lawyers, Angel Place, Level 27, 123 Pitt Street Sydney 2000, Australia</td></tr><tr><td>Sierra Oncology Canada ULC</td><td>Common</td><td>355 Burrard Street, Suite 1000, Vancouver, British Columbia V6C 2G8, Canada</td></tr><tr><td>Sierra Oncology Canada, LLC</td><td>LLC Interests</td><td>Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808, United States</td></tr><tr><td>Sierra Oncology, LLC</td><td>Common Stock</td><td>Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808, United States</td></tr><tr><td>Sitari Pharma, Inc.</td><td>Common Stock</td><td>Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808, United States</td></tr><tr><td>Smith Kline &amp; French Portuguesa-Produtos Farmaceuticos, LDA (ii)</td><td>Ordinary</td><td>Rua Dr Antonio Loureiro Borges No 3, Arquiparque, Miraflores, 1495-131, Alges, Portugal</td></tr><tr><td>SmithKline Beecham (Bangladesh) Private Limited (ii)</td><td>Ordinary</td><td>House-2/A, Road-138,Gulshan-1, Dhaka, 1212, Bangladesh</td></tr><tr><td>SmithKline Beecham (Cork) Limited</td><td>Ordinary</td><td>12 Riverwalk, Citywest Business Campus, Dublin 24, Ireland</td></tr><tr><td>SmithKline Beecham (Manufacturing) Limited (In Liquidation)</td><td>Ordinary</td><td>12 Riverwalk, Citywest Business Campus, Dublin 24, Ireland</td></tr><tr><td>SmithKline Beecham Egypt L.L.C.</td><td>Quotas</td><td>Amoun Street, El Salam City, Cairo, Egypt</td></tr><tr><td>SmithKline Beecham Farma, S.A.</td><td>Ordinary</td><td>Severo Ochoa, 2, Parque Tecnologico de Madrid, Tres Contos, 28760, Madrid, Spain</td></tr><tr><td>SmithKline Beecham Limited</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>SmithKline Beecham Legacy H Limited</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>SmithKline Beecham Pension Plan Trustee Limited (ii)</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>SmithKline Beecham Pension Trustees Limited (In Liquidation)</td><td>Ordinary</td><td>55 Baker Street, London, WIU 7EU, United Kingdom</td></tr><tr><td>SmithKline Beecham Pharma GmbH &amp; Co KG</td><td>Partnership Capital</td><td>Prinzregentenplatz 9, 81675, Munchen, Germany</td></tr><tr><td>SmithKline Beecham Pharma Verwaltungs GmbH</td><td>Ordinary</td><td>Prinzregentenplatz 9, 81675, Munchen, Germany</td></tr><tr><td>SmithKline Beecham Pharmaceuticals (Pty) Limited (ii)</td><td>Ordinary</td><td>Flushing Meadows Building, The Campus, 57 Sloane Street, Bryanston 2021, South Africa</td></tr><tr><td>SmithKline Beecham Pharmaceuticals Co.</td><td>Common</td><td>Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808, United States</td></tr><tr><td>SmithKline Beecham Senior Executive Pension Plan Trustee Limited (ii)</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>Stiefel GmbH &amp; Co. KG</td><td>Partnership Capital</td><td>Prinzregentenplatz 9, 81675, Munchen, Germany</td></tr><tr><td>Stiefel Laboratories Legacy (Ireland) Limited</td><td>Ordinary</td><td>Unit 2 Building 2500, Avenue 2000 Cork Airport Business Park, Cork, Ireland</td></tr><tr><td>Stiefel Laboratories Limited (In liquidation)</td><td>Ordinary</td><td>c/o BDO LLP, 5 Temple Square, Temple Street, Liverpool, L2 5RH, United Kingdom</td></tr><tr><td>Stiefel Laboratories Pte Limited</td><td>Ordinary</td><td>1 Pioneer Sector, 628413, Singapore</td></tr><tr><td>Stiefel Laboratories, Inc.</td><td>Common</td><td>Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808, United States</td></tr><tr><td>Stiefel Maroc SARL</td><td>Ordinary</td><td>275 Boulevard Zerkoutni, Casablanca, Morocco</td></tr><tr><td>Stiefel Research (Australia) Holdings Pty Ltd</td><td>Ordinary</td><td>1061 Mountain Highway, Boronia Victoria VIC 3155, Australia</td></tr><tr><td>Stiefel Research Australia Pty Ltd</td><td>Ordinary</td><td>1061 Mountain Highway, Boronia Victoria VIC 3155, Australia</td></tr><tr><td>Stiefel West Coast LLC</td><td>LLC Interests</td><td>Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808, United States</td></tr><tr><td>Strebor Inc.</td><td>Common</td><td>Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808, United States</td></tr></table>



## Other statutory disclosures continued

Group companies continued

<table><tr><td>Name</td><td>Security</td><td>Registered address</td></tr><tr><td colspan="3">Wholly owned subsidiaries continued</td></tr><tr><td>Tesaro Bio GmbH (In Liquidation)</td><td>Ordinary</td><td>Poststrasse 6, 6300 Zug, Switzerland</td></tr><tr><td>Tesaro Bio Netherlands BV</td><td>Ordinary</td><td>Joop Geesinkweg 901, 1114 AB, Amsterdam-Duivendrecht, Netherlands</td></tr><tr><td>Tesaro Development, Ltd.</td><td>Ordinary</td><td>Clarendon House, 2 Church Street, Hamilton HM11, Bermuda</td></tr><tr><td>Tesaro, Inc.</td><td>Common</td><td>Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808, United States</td></tr><tr><td>The Sydney Ross Co. (i)</td><td>Ordinary</td><td>Corporation Service Company, Princeton South Corporate Center, Suite 160, 100 Charles Ewing Blvd, Ewing NJ 08628, United States</td></tr><tr><td>UCB Pharma Asia Pacific Sdn Bhd (ii)</td><td>Ordinary</td><td>12th Floor, Menara Symphony, No. 5, Jalan Prof. Khoo Kay Kim, Seksyen 13, 46200 Petaling Jaya, Malaysia</td></tr><tr><td>Wellcome Consumer Healthcare Limited (i)</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>Wellcome Consumer Products Limited (In Liquidation)</td><td>Ordinary</td><td>c/o BDO LLP, 5 Temple Square, Temple Street, Liverpool, L2 5RH, United Kingdom</td></tr><tr><td>Wellcome Limited</td><td>Ordinary</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>Name</td><td>Security</td><td>Effective % Ownership</td></tr><tr><td colspan="3">Subsidiaries where the effective interest is less than 100%</td></tr><tr><td>Amoun Pharmaceutical Industries Co. S.A.E.</td><td>New Monetary Shares (99.5%)</td><td>90.71%</td></tr><tr><td>Biddle Sawyer Limited</td><td>Equity</td><td>75.00%</td></tr><tr><td>British Pharma Group Limited</td><td>Capital (50%)</td><td>50.00%</td></tr><tr><td>Galvani Bioelectronics Inc.</td><td>Common</td><td>55.00%</td></tr><tr><td>Galvani Bioelectronics Limited</td><td>A Ordinary; B Ordinary (0%)</td><td>55.00%</td></tr><tr><td>Glaxo Saudi Arabia Limited</td><td>Ordinary</td><td>75.00%</td></tr><tr><td>GlaxoSmithKline (Tianjin) Co. Ltd</td><td>Ordinary</td><td>90.00%</td></tr><tr><td>GlaxoSmithKline Algérie S.P.A.</td><td>Ordinary</td><td>9999%</td></tr><tr><td>GlaxoSmithKline Consumer Nigeria plc</td><td>Ordinary</td><td>46.42%</td></tr><tr><td>GlaxoSmithKline Pakistan Limited</td><td>Ordinary</td><td>82.59%</td></tr><tr><td>GlaxoSmithKline Pharmaceuticals Limited</td><td>Equity</td><td>75.00%</td></tr><tr><td>GlaxoSmithKline S.A.E.</td><td>Ordinary</td><td>91.20%</td></tr><tr><td>GSK (No.1) Scottish Limited Partnership (ix)</td><td>Partnership</td><td>-</td></tr><tr><td>GSK (No. 2) Scottish Limited Partnership (ix)</td><td>Partnership</td><td>-</td></tr><tr><td>Laboratorios ViV Healthcare, S.L.</td><td>Ordinary</td><td>78.30%</td></tr><tr><td>Modern Pharma Trading Company LLC.</td><td>Quotas</td><td>91.20%</td></tr><tr><td>PHIVCO-1 LLC</td><td>LLC Interests</td><td>78.30%</td></tr><tr><td>PHIVCO-2 LLC</td><td>LLC Interests</td><td>78.30%</td></tr><tr><td>Shionogi-ViV Healthcare LLC (i)</td><td>Common Interests</td><td>78.30%</td></tr><tr><td>SmithKline Beecham-Biomed OOO.</td><td>Participation Interest</td><td>97.00%</td></tr><tr><td>Stiefel Egypt LLC (i)</td><td>Quotas</td><td>99.00%</td></tr><tr><td>ViV Healthcare (South Africa) (Proprietary) Limited</td><td>Ordinary</td><td>78.30%</td></tr><tr><td>ViV HealthCare BV</td><td>Ordinary</td><td>78.30%</td></tr><tr><td>ViV Healthcare Company</td><td>Common</td><td>78.30%</td></tr><tr><td>ViV Healthcare Finance 1 Limited (In liquidation)</td><td>Ordinary</td><td>78.30%</td></tr><tr><td>ViV Healthcare Finance 2 Limited</td><td>Ordinary</td><td>78.30%</td></tr><tr><td>ViV Healthcare Finance Limited</td><td>Ordinary; Redeemable Preference</td><td>78.30%</td></tr><tr><td>ViV Healthcare GmbH</td><td>Ordinary</td><td>78.30%</td></tr><tr><td>ViV Healthcare GmbH</td><td>Ordinary</td><td>77.30%</td></tr></table>



## Other statutory disclosures continued

<table><tr><td colspan="4">Group companies continued</td></tr><tr><td>Name</td><td>Security</td><td>Effective % Ownership</td><td>Registered address</td></tr><tr><td colspan="4">Subsidiaries where the effective interest is less than 100% continued</td></tr><tr><td>ViV Healthcare Hong Kong Limited</td><td>Ordinary</td><td>78.30%</td><td>23/F Tower 6, The Gateway, 9 Canton Road, Harbour City, Tsimshatsui, Kowloon, Hong Kong</td></tr><tr><td>ViV Healthcare K.K.</td><td>Ordinary</td><td>78.30%</td><td>1-8-1 Akasaka Minato-ku, Tokyo, Japan</td></tr><tr><td>ViV Healthcare Limited</td><td>A Ordinary; B Ordinary; C Ordinary; DI Preference; D2 Ordinary; Deferred; E 5% Cumulative Preference</td><td>78.30%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>ViV Healthcare Pty Ltd</td><td>Ordinary</td><td>78.30%</td><td>1061 Mountain Highway, Boronia Victoria VIC 3155, Australia</td></tr><tr><td>ViV Healthcare Puerto Rico, LLC</td><td>LLC Interests</td><td>78.30%</td><td>Corporation Service Company Puerto Rico Inc., c/o RVM Professional Services, LLC, A4 Reparto Mendoza, Humacao, Puerto Rico, 00791</td></tr><tr><td>ViV Healthcare Srl.</td><td>Quotas</td><td>78.30%</td><td>Viale dell&#x27;Agricoltura 7, 37135, Verona, Italy</td></tr><tr><td>ViV Healthcare SAS</td><td>Ordinary</td><td>78.30%</td><td>23 rue François Jacob, 92500, Rueil-Malmaison, France</td></tr><tr><td>ViV Healthcare sprl</td><td>Ordinary</td><td>78.30%</td><td>Site Apollo, Avenue Pascal 2-4-6, Wavre, 1300, Belgium</td></tr><tr><td>ViV Healthcare Trading LLC (i)</td><td>Participation Interest</td><td>78.30%</td><td>Leningradskiy Prospect 37A, Building 4, Floor 2, Premises XIV, Room 28, 125167, Moscow, Russian Federation</td></tr><tr><td>ViV Healthcare Trading Services UK Limited</td><td>Ordinary</td><td>78.30%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>ViV Healthcare UK (No.3) Limited</td><td>Ordinary</td><td>78.30%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>ViV Healthcare UK (No.4) Limited</td><td>Ordinary</td><td>78.30%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>ViV Healthcare UK (No.5) Limited</td><td>Ordinary</td><td>78.30%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>ViV Healthcare UK (No.6) Limited</td><td>Ordinary</td><td>78.30%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>ViV Healthcare UK (No.7) Limited</td><td>Ordinary</td><td>78.30%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>ViV Healthcare UK Limited</td><td>Ordinary</td><td>78.30%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td></tr><tr><td>ViV Healthcare LLC</td><td>Common</td><td>78.30%</td><td>3500 855-2nd Street SW, Calgary AB T2P 4J8, Canada</td></tr><tr><td>ViV Healthcare Venture LLC</td><td>LLC Interest</td><td>78.30%</td><td>Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808, United States</td></tr><tr><td>ViVHIV Healthcare Unipessoal Lda</td><td>Quota</td><td>78.30%</td><td>Rua Dr Antonio Loureiro Borges No 3, Arquiparque, Miraflores, 1495-131, Alges, Portugal</td></tr><tr><td>Winstor Pharmaceuticals Limited</td><td>Ordinary</td><td>46.42%</td><td>2A Association Avenue, Ilupeju Industrial Estate, Lagos, PO Box 3199, Nigeria</td></tr><tr><td>Name</td><td>Security</td><td>Effective % Ownership</td><td>Registered address</td></tr><tr><td colspan="4">Associates</td></tr><tr><td>GlaxoSmithKline Landholding Company, Inc</td><td>Common</td><td>3993%</td><td>23rd Floor, The Finance Centre, 26th Street Corner 9th Avenue, Bonifacio Global City, Taguig City, 1634, Philippines</td></tr><tr><td>Index Ventures Life VI (Jersey) LP</td><td>Partnership Interest (25%)</td><td>25.00%</td><td>44 Esplanade, St Helier, Jersey, JE4 9WG, Channel Islands</td></tr><tr><td>Kurma Biofund II FCPR</td><td>Partnership Interest (32.06%)</td><td>32.06%</td><td>24 rue Royale, 5th Floor, 75008, Paris, France</td></tr><tr><td>Longwood Fund I LP</td><td>Partnership Interest (35%)</td><td>35.00%</td><td>The Prudential Tower, Suite 1555, 800 Boylston Street, Boston, MA 02199</td></tr><tr><td>Medicxi Ventures I LP</td><td>Partnership Interest (26.19%)</td><td>26.19%</td><td>44 Esplanade, St Helier, Jersey, JE4 9WG, Channel Islands</td></tr><tr><td colspan="4">Joint Ventures</td></tr><tr><td>Chiron Panacea Vaccines Private Limited</td><td>Equity Shares</td><td>50.00%</td><td>708/718, 7th Floor, A Wing, Sagar Tech Plaza, Saki Naka, Andheri East, Mumbai, Maharashtra, 400072, India</td></tr><tr><td>Qualivax Pte. Limited</td><td>Ordinary</td><td>50.00%</td><td>80 Robinson Road, #02-00, 068898, Singapore</td></tr><tr><td>Qura Therapeutics, LLC</td><td>Units</td><td>39.15%</td><td>Corporation Service Company, 251 Little Falls Drive, Wilmington DE 19808, United States</td></tr><tr><td colspan="4">Other significant holdings</td></tr><tr><td>Axon Therapies, Inc</td><td>Common (3.39%); Series A Preference (16.10%)</td><td>20.03%</td><td>315 west 36th street, New York 10018, USA</td></tr><tr><td>Alpheus Medical, Inc.</td><td>Series A Preference (13.8%); Series A1 Preference (72.9%)</td><td>21.09%</td><td>3510 Hopkins Place, North Oakdale, Minnesota 55128, USA</td></tr><tr><td>Global Farm S.A.</td><td>A Shares (0%); B Shares (0%); C Shares (100%)</td><td>20.00%</td><td>Mendoza 1259, Ciudad Autónoma de Buenos Aires, Argentina</td></tr><tr><td>Longwood Fund II, LP</td><td>Partnership Interest (20.03%)</td><td>20.03%</td><td>The Prudential Tower, Suite 1555, 800 Boylston Street, Boston, MA 02199</td></tr><tr><td>Sanderling Ventures VII, LP A63</td><td>Partnership Interest (25.25%)</td><td>25.25%</td><td>400 S. El Camino Real, Suite 1200, San Mateo, CA 94402</td></tr><tr><td>SR One Capital Fund I-B, LP</td><td>Partnership Interest (44%)</td><td>44.00%</td><td>Corporation service company, 251 Little Falls Drive, City of Wilmington, County of New Castle, Delaware 19808</td></tr></table>



## Other statutory disclosures continued

## Group companies continued

The following UK subsidiaries will take advantage of the audit exemption set out within Section 479A of the Companies Act 2006 for the period ended 31 December 2022. Unless otherwise stated, the undertakings listed below are owned, either directly or indirectly, by GSK plc.

<table><tr><td>Name</td><td>Security</td><td>Effective % Ownership</td><td>Registered address</td><td>Company Number</td></tr><tr><td colspan="5">UK registered subsidiaries exempted from audit</td></tr><tr><td>Burroughs Wellcome International Limited</td><td>Ordinary</td><td>100.00%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td><td>543757</td></tr><tr><td>Domantis Limited</td><td>Ordinary</td><td>100.00%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td><td>3907643</td></tr><tr><td>Edinburgh Pharmaceutical Industries Limited (ii)</td><td>Ordinary; Preference;</td><td>100.00%</td><td>Shewaton Road, Irvine, Ayrshire, KA11 5AP, United Kingdom</td><td>SC005534</td></tr><tr><td>Eskaylab Limited</td><td>Ordinary</td><td>100.00%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td><td>99025</td></tr><tr><td>Glaxo Wellcome UK Limited</td><td>Ordinary</td><td>100.00%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td><td>480080</td></tr><tr><td>Glaxo Wellcome International B.V. (iii)</td><td>Ordinary</td><td>100.00%</td><td>Huis ter Heideweg 62, 3705 LZ, Zeist, Netherlands</td><td>30150600</td></tr><tr><td>Glaxochem (UK) Unlimited</td><td>Ordinary; Ordinary B; Ordinary C</td><td>100.00%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td><td>4299472</td></tr><tr><td>GlaxoSmithKline Intellectual Property (No.3) Limited</td><td>Ordinary</td><td>100.00%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td><td>11480952</td></tr><tr><td>GlaxoSmithKline Intellectual Property (No.4) Limited</td><td>Ordinary</td><td>100.00%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td><td>11721880</td></tr><tr><td>GlaxoSmithKline Intellectual Property (No.5) Limited</td><td>Ordinary</td><td>100.00%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td><td>11959399</td></tr><tr><td>GlaxoSmithKline International Limited</td><td>Ordinary</td><td>100.00%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td><td>2298366</td></tr><tr><td>GSK Capital B.V. (iii) (v)</td><td>Ordinary</td><td>100.00%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td><td>81761198</td></tr><tr><td>GSK GP 1 Limited (iv)</td><td>A Shares; B Shares (0%)</td><td>9900%</td><td>50 Lothian Road, Festival Square, Edinburgh, Scotland, EH3 9WJ, United Kingdom</td><td>SC721605</td></tr><tr><td>GSK GP 2 Limited (iv)</td><td>Ordinary</td><td>100.00%</td><td>50 Lothian Road, Festival Square, Edinburgh, Scotland, EH3 9WJ, United Kingdom</td><td>SC721606</td></tr><tr><td>GSK LP Limited (iv)</td><td>Ordinary</td><td>100.00%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td><td>13879411</td></tr><tr><td>Montrose Fine Chemical Company Ltd.</td><td>Ordinary</td><td>100.00%</td><td>Shewaton Road, Irvine, Ayrshire, KA11 5AP, United Kingdom</td><td>SC190635</td></tr><tr><td>PHIVCO UK II Limited</td><td>Ordinary</td><td>78.30%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td><td>6944229</td></tr><tr><td>PHIVCO UK Limited</td><td>Ordinary</td><td>78.30%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td><td>6944223</td></tr><tr><td>Smith Kline &amp; French Laboratories Limited</td><td>Ordinary</td><td>100.00%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td><td>52207</td></tr><tr><td>SmithKline Beecham (Export) Limited</td><td>Ordinary</td><td>100.00%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td><td>2860752</td></tr><tr><td>SmithKline Beecham (H) Limited</td><td>Non-cumulative Non-redeemable; Ordinary</td><td>100.00%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td><td>3296131</td></tr><tr><td>SmithKline Beecham (Investments) Limited</td><td>Ordinary</td><td>100.00%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td><td>302065</td></tr><tr><td>SmithKline Beecham Marketing and Technical Services Limited</td><td>Ordinary</td><td>100.00%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td><td>494385</td></tr><tr><td>SmithKline Beecham Nominees Limited</td><td>Ordinary</td><td>100.00%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td><td>503868</td></tr><tr><td>SmithKline Beecham Overseas Limited</td><td>Ordinary</td><td>100.00%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td><td>2552828</td></tr><tr><td>Stiefel Laboratories (UK) Ltd</td><td>Ordinary</td><td>100.00%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td><td>831160</td></tr><tr><td>Tesaro UK Limited</td><td>Ordinary</td><td>100.00%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td><td>7890847</td></tr><tr><td>The Wellcome Foundation Limited</td><td>Ordinary</td><td>100.00%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td><td>194814</td></tr><tr><td>ViiV Healthcare Overseas Limited</td><td>Ordinary</td><td>78.30%</td><td>980 Great West Road, Brentford, Middlesex, TW8 9GS, England</td><td>7027385</td></tr></table>

In accordance with Section 479C of the Companies Act 2006, the company will guarantee debts and liabilities of the above UK subsidiary undertakings. As at 31 December 2022 the total sum of these debts and liabilities is £1,266 million (2021 – £876 million)

## Key

(i) Directly owned by GSK plc.

(ii) Dormant entity.

(iii) Tax resident in the UK.

(iv) Exempt under Regulation 7 of the Partnership (Accounts) Regulations 2008 from the requirement to deliver to the registrar financial statements of the qualifying partnership(s) of which the entity is a member in accordance with the Companies Act.

(v) Incorporated in the Netherlands

(vi) Consolidated as a subsidiary in accordance with Section 1162 (4)(a) of the Companies Act 2006 on the grounds of dominant influence.

(vii) Principal business address in Puerto Rico.

(viii) Exempt from the provisions of Regulations 4-6 of the Partnership (Accounts) Regulation 2008, in accordance with the exemptions noted in Regulation 7 of that Regulation.

(i×) GSK GP 1 Limited is a subsidiary undertaking of GSK plc and Berkeley Square Pension Trustee Company Limited and is the general partner of GSK (No.1) Scottish Limited Partnership and GSK (No.2) Scottish Limited Partnership. GSK GP 1 Limited's share capital is 99% indirectly owned by GSK plc and 1% owned by Berkeley Square Pension Trustee Company Limited.

(x) GSK GP 2 Limited is a subsidiary undertaking of GSK plc and is the general partner of GSK (No.3) Scottish Limited Partnership. GSK GP 2 Limited's share capital is 100% indirectly owned by GSK plc.



## Glossary of terms

<table><tr><td>Terms used in the Annual Report</td><td>US equivalent or brief description</td></tr><tr><td>Accelerated capital allowances</td><td>Tax allowance in excess of depreciation arising from the purchase of fixed assets that delay the charging and payment of tax. The equivalent of tax depreciation.</td></tr><tr><td>American Depositary Receipt (ADR)</td><td>Receipt evidencing title to an ADS. Each GSK ADR represents two Ordinary Shares.</td></tr><tr><td>American Depositary Shares (ADS)</td><td>Listed on the New York Stock Exchange; represents two Ordinary Shares.</td></tr><tr><td>Basic earnings per share</td><td>Basic income per share.</td></tr><tr><td>Called up share capital</td><td>Ordinary Shares, issued and fully paid.</td></tr><tr><td>CER growth</td><td>Growth at constant exchange rates.</td></tr><tr><td>The company</td><td>GSK plc.</td></tr><tr><td>Currency swap</td><td>An exchange of two currencies, coupled with a subsequent re-exchange of those currencies, at agreed exchange rates and dates.</td></tr><tr><td>Defined benefit plan</td><td>Pension plan with specific employee benefits, often called &#x27;final salary scheme&#x27;.</td></tr><tr><td>Defined contribution plan</td><td>Pension plan with specific contributions and a level of pension dependent upon the growth of the pension fund.</td></tr><tr><td>Derivative financial instrument</td><td>A financial instrument that derives its value from the price or rate of some underlying item.</td></tr><tr><td>Diluted earnings per share</td><td>Diluted income per share.</td></tr><tr><td>Employee Share Ownership Plan Trusts</td><td>Trusts established by the Group to satisfy share-based employee incentive plans.</td></tr><tr><td>Equity Shareholders&#x27; funds</td><td>Shareholders&#x27; equity.</td></tr><tr><td>Finance lease</td><td>Capital lease.</td></tr><tr><td>Freehold</td><td>Ownership with absolute rights in perpetuity.</td></tr><tr><td>The Group</td><td>GSK plc and its subsidiary undertakings.</td></tr><tr><td>GSK</td><td>GSK plc and its subsidiary undertakings.</td></tr><tr><td>Hedging</td><td>The reduction of risk, normally in relation to foreign currency or interest rate movements, by making off-setting commitments.</td></tr><tr><td>Intangible fixed assets</td><td>Assets without physical substance, such as computer software, brands, licences, patents, know-how and marketing rights purchased from outside parties.</td></tr><tr><td>Ordinary share</td><td>A fully paid up ordinary share in the capital of the company.</td></tr><tr><td>Profit</td><td>Income.</td></tr><tr><td>Profit attributable to shareholders</td><td>Net income.</td></tr><tr><td>Share capital</td><td>Ordinary Shares, capital stock or common stock issued and fully paid.</td></tr><tr><td>Share option</td><td>Stock option.</td></tr><tr><td>Share premium account</td><td>Additional paid-up capital or paid-in surplus (not distributable).</td></tr><tr><td>Shares in issue</td><td>The number of shares outstanding.</td></tr><tr><td>Subsidiary</td><td>An entity in which GSK exercises control.</td></tr><tr><td>Treasury share</td><td>Treasury stock.</td></tr><tr><td>Turnover</td><td>Revenue.</td></tr><tr><td>UK Corporate Governance Code</td><td>As required by the UK Listing Authority, the company has disclosed in the Annual Report how it has applied the best practice corporate governance provisions of the Financial Reporting Council&#x27;s UK Corporate Governance Code.</td></tr></table>



## Index

2022 Remuneration policy summary 133
Access 43
Accounting principles and policies 186
Acquisitions and disposals 237
Adjustments reconciling Total profit after tax to operating cash flows 242
Annual General Meeting 2023 299
Approach to tax 92
Assets held for sale 216
Associates and joint ventures 203
Audit & Risk Committee Report 124
Business model 08
Cash and cash equivalents 216
Cash generation and conversion 86
CEO's statement 06
Chair's statement 04
Chair's Governance statement 103
Chair's Remuneration annual statement 133
Climate-related financial disclosure 55
Commitments 232
Consolidated balance sheet 183
Consolidated cash flow statement 185
Consolidated income statement 182
Consolidated statement of changes in equity 184
Consolidated statement of comprehensive income 182
Contingent consideration liabilities 231
Contingent liabilities 232
Corporate governance 96
Corporate Responsibility Committee Report 117
Critical accounting judgements and key sources of estimation uncertainty 192
Critical accounting policies 94
Data and engagement 49
Demerger of Consumer Healthcare business 238
Directors and senior management 156
Directors' interests in shares 154
Directors' report 130
Directors' statement of responsibilities 166
Dividends 207
Donations to political organisations and political expenditure 306
Earnings per share 207
Employee costs 200
Employee share schemes 262
Environment 45
Ethical standards 48
Exchange rates 194
Finance expense 202
Finance income 202
Financial calendar 2023 299
Financial instruments and related disclosures 245
Financial performance 68
Financial position and resources 87
Financial statements of GSK plc, prepared under UK GAAP 268
General Medicines 38,75
Glossary of terms 215
Goodwill 210
Group companies 307
Group financial review 65
GSK Leadership Team 101
Independent Auditor's report 168
Innovation 09
Inventories 215
Investments in associates and joint ventures 213
Investor relations 303

Key performance indicators 02
Legal proceedings 265
Major restructuring costs 201
Movements in equity 233
Net debt 218
New accounting requirements 194
Nominations Committee Report 120
Non-controlling interests 235
Non-controlling interests in ViiV Healthcare 71
Non-Executive Directors' fees 152
Non-financial information statement 63
Notes to the financial statements 186
Operating profit 199
Other intangible assets 211
Other investments 214
Other non-current assets 215
Other non-current liabilities 232
Other operating income/(expense) 198
Other provisions 229
Our culture 10
Our external environment 12
Our long-term priorities 09
Pensions and other post-employment benefits 220
Performance 02
Pharmaceutical products, competition and intellectual property 281
Pipeline 278
Post balance sheet events 267
Presentation of the financial statements 269
Principal Group companies 264
Principal risks and uncertainties 285
Property, plant and equipment 208
Reconciliation of net cash flow to movement in net debt 243
Registrar 302
Related party transactions 236
Reliable supply 17
Remuneration governance 150
Remuneration report 132
Reporting framework 69
Responsible business 42
Right of use assets 209
Risk management 51
Science and technology 16
Science Committee report 118
Section 172 statement 112
Share capital and control 296
Share capital and share premium account 233
Share Consolidation 233
Shareholder information 296
Shareholder services and contacts 302
Specialty Medicines 33,73
Stakeholder engagement 112
Task Force on Climate-related Financial Disclosures 55
Taxation 204
Tax information for shareholders 299
Three-year selected financial data 276
The Board 97
Trade and other payables 217
Trade and other receivables 215
Treasury policies 93
Trust 09
Turnover and segment information 195
US law and regulation 304
Vaccines 29,74
Vaccine products, competition and intellectual property 284
Viability statement 64



## About GSK

GlaxoSmithKline plc was incorporated as an English public limited company on 6 December 1999. We were formed by a merger between Glaxo Wellcome plc and SmithKline Beecham plc. GSK acquired these two English companies on 27 December 2000 as part of the merger arrangements. Effective 15 May 2022 GlaxoSmithKline plc changed its name to GSK plc. On 18 July 2022, GSK plc, separated its Consumer Healthcare business from the GSK Group to form Haleon, an independent listed company.

Our shares are listed on the London Stock Exchange and the New York Stock Exchange.

www.gsk.com

Brand names appearing in italics throughout this report are trade marks either owned by and/or licensed to GSK or associated companies. All other trade marks are the property of their respective owners.

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– Annual Report 2022

– Form 20-F

– ESG Performance Report 2022

## Cautionary statement regarding forward-looking statements

The Group’s reports filed with or furnished to the US Securities and Exchange Commission (SEC), including this document, and any other written information released, or oral statements made, to the public in the future by or on behalf of the Group, may contain forward-looking statements. Forward-looking statements give the Group’s current expectations or forecasts of future events. An investor can identify these statements by the fact that they do not relate strictly to historical or current facts. They use words such as ‘anticipate’, ‘estimate’, ‘expect’, ‘intend’, ‘will’, ‘project’, ‘plan’, ‘believe’, ‘target’ and other words and terms of similar meaning in connection with any discussion of future operating or financial performance. In particular, these include statements relating to future actions, prospective products or product approvals, future performance or results of current and anticipated products, sales efforts, expenses, the outcome of contingencies such as legal proceedings, dividend payments and financial results. Other than in accordance with its legal or regulatory obligations (including under the Market Abuse Regulations, the UK Listing Rules and the Disclosure and Transparency Rules of the Financial Conduct Authority), the Group undertakes no obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise. The reader should, however, consult any additional disclosures that the Group may make in any documents which it publishes and/or files with the SEC. All readers, wherever located, should take note of these disclosures. Accordingly, no assurance can be given that any particular expectation will be met and investors are cautioned not to place undue reliance on the forward-looking statements.

Forward-looking statements are subject to assumptions, inherent risks and uncertainties, many of which relate to factors that are beyond the Group's control or precise estimate. The Group cautions investors that a number of important factors, including those in this document, could cause actual results to differ materially from those expressed or implied in any forward-looking statement.

Such factors include, but are not limited to, those discussed under 'Principal risks and uncertainties' on pages 285 to 295 of this Annual Report and any impacts of the COVID-19 pandemic. Any forward-looking statements made by or on behalf of the Group speak only as of the date they are made and are based upon the knowledge and information available to the Directors on the date of this Annual Report.

A number of non-IFRS measures are used to report the performance of our business. These measures are defined on pages 69 to 70 and a reconciliation of Adjusted results to Total results is set out on pages 81 to 85.

The information in this document does not constitute an offer to sell or an invitation to buy shares in GSK plc or an invitation or inducement to engage in any other investment activities. Past performance cannot be relied upon as a guide to future performance. Nothing in this Annual Report should be construed as a profit forecast.

## Assumptions related to 2023 guidance

In outlining the guidance for 2023, the Group has made certain assumptions about the healthcare sector, the different markets in which the Group operates and the delivery of revenues and financial benefits from its current portfolio, pipeline and restructuring programmes. Due to the phasing of quarterly results in 2022 and the resulting comparators, GSK expects turnover and Adjusted operating profit growth to be slightly lower in the first half of 2023 including a challenging comparator in Q1 2022 and somewhat higher in the second half, relative to full-year expectations. Despite the recovery of healthcare systems, uncertain economic conditions prevail across many markets in which GSK operates and we continue to expect to see variability in performance between quarters.

We expect sales of Specialty Medicines to increase mid to high single-digit per cent, sales of Vaccines to increase mid-teens per cent and sales of General Medicines to decrease slightly.

These planning assumptions as well as operating profit guidance and dividend expectations assume no material interruptions to supply of the Group's products, no material mergers, acquisitions or disposals, no material litigation or investigation costs for the Company (save for those that are already recognised or for which provisions have been made) and no change in the Group's shareholdings in ViiV Healthcare. The assumptions also assume no material changes in the healthcare environment or unexpected significant changes in pricing as a result of government or competitor action. The 2023 guidance factors in all divestments and product exits announced to date.

The Group’s guidance assumes successful delivery of the Group’s integration and restructuring plans. Material costs for investment in new product launches and R&D have been factored into the expectations given. Given the potential development options in the Group’s pipeline, the outlook may be affected by additional data-driven R&D investment decisions. The guidance is given on a constant currency basis.

All outlooks, ambitions and expectations should be read together with pages 5-7 of the Stock Exchange announcement relating to an update to investors dated 23 June 2021, paragraph 19 of Part 7 of the Circular to shareholders relating to the demerger of Haleon dated 1 June 2022 and the Guidance, assumptions and cautionary statements in the Group's Q4 2022 earnings release.

## Notice regarding limitations on Director Liability under English Law

Under the UK Companies Act 2006, a safe harbour limits the liability of Directors in respect of statements in and omissions from the Directors' Report (for which see page 117), the Strategic report and the Remuneration report. Under English law the Directors would be liable to the company, but not to any third party, if one or more of these reports contained errors as a result of recklessness or knowing misstatement or dishonest concealment of a material fact, but would otherwise not be liable. Pages 97, 131, 166 to 167, and 285 to 314 inclusive comprise the Directors' Report, pages 1 to 95 inclusive comprise the Strategic report and pages 133 to 164 inclusive comprise the Remuneration report, each of which have been drawn up and presented in accordance with and in reliance upon English company law and the liabilities of the Directors in connection with these reports shall be subject to the limitations and restrictions provided by such law.

## Website

GSK’s website www.gsk.com gives additional information on the Group. Notwithstanding the references we make in this Annual Report to GSK’s website, none of the information made available on the website constitutes part of this Annual Report or shall be deemed to be incorporated by reference herein.



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