Gilead Sciences, Inc. (GILD, NASDAQ)
Industry: Drug Manufacturers - General
Annual report, fiscal year 2012


GILEAD SCIENCES ANNUAL REPORT 2012



## WELCOME TO
GILEAD.

COVER:
Katie has been living with HIV since she was an infant. Growing up in Maryland, she faced stigma at a very young age because of her disease. Despite this experience, she maintains a positive outlook on life, which she credits to her supportive family and friends. Because she knows first-hand the importance of support for people facing serious health challenges, Katie plans to devote her career to helping those in need. She recently graduated from the University of Central Florida and aims to pursue a master's degree in public health.

WE ARE INSPIRED BY
THE OPPORTUNITY
TO ADDRESS UNMET
MEDICAL NEEDS
FOR PATIENTS WITH
LIFE-THREATENING
DISEASES AROUND
THE WORLD.



## DEDICATION: HIV/AIDS AT A TURNING POINT



## Stribild \( ^{®} \)  Approved for HIV

Because of their effectiveness, safety profiles and convenience, single tablet regimens have become a standard of care for HIV. A single tablet regimen combining the multiple drugs required for HIV treatment helps ensure patients take all of their medicine, avoiding partial doses which can lead to resistance to therapy. To this end, in 2012 we achieved a significant milestone: the approval by the U.S. Food and Drug Administration (FDA) of Stribild, a fixed-dose formulation of four Gilead medicines in a once-daily pill for treatment-naive patients. It’s our third single tablet regimen for HIV, joining Atripla \( ^{®} \)  and Complera \( ^{®} \)  which are among the most-prescribed antiretroviral regimens in the United States and Europe.



## New Tools for HIV Prevention

In July 2012, Truvada \( ^{®} \)  became the first product approved by FDA in combination with safer sex practices to reduce the risk of HIV in uninfected adults at high risk, a strategy called pre-exposure prophylaxis (PrEP). At the 2012 International AIDS Conference—the largest gathering of scientists, clinicians, public health experts and advocates committed to eradicating the disease—a sense of growing optimism prevailed. The approval of Truvada for PrEP was noted as a milestone that could help slow the spread of HIV in communities at greatest risk, offering new hope for bringing the epidemic under control. While great progress in diagnosis and linkage to care for individuals with HIV has occurred in the last several years, HIV prevention remains a challenge around the world.

Jamie was diagnosed with HIV in 2008. In order to cope with the fear he experienced at the time of his diagnosis, Jamie educated himself extensively about the disease and worked closely with his doctor to find the right treatment. With his doctor’s encouragement, he began antiretroviral therapy right away. Today, among many other interests, Jamie maintains a passion for travel and the outdoors—recently visiting a small fishing village in Mexico and Patagonia.



## INNOVATION:
NEW TREATMENT
OPTIONS
FOR CHRONIC
HEPATITIS C



## Transforming Treatment
Paradigms

Current interferon-based regimens available for treating hepatitis C remain a challenge for patients due to safety issues, side effects, variable response rates and burdensome injections. Because of this, Gilead is advancing the development of all-oral hepatitis C medicines with the goal of improving tolerability and convenience and increasing cure rates. In November 2012, we reported a 100 percent sustained virologic response rate (SVR4*) for treatment-naive genotype 1 hepatitis C patients enrolled in a Phase 2 trial evaluating an all-oral combination of sofosbuvir (GS-7977) and ledipasvir (GS-5885) with ribavirin. Based on these data, sofosbuvir and ledipasvir have been co-formulated into a single pill, which is now being studied in Phase 3 trials.



## Accelerating Clinical Development

Following the acquisition of Pharmasset in January 2012, we moved quickly to expand clinical testing of hepatitis C therapies. Phase 3 trials exploring sofosbuvir in various combinations with other agents in genotype 1-6 patient populations are ongoing. In 2012, there were 21 new studies initiated, enrolling more than 2,680 participants, and because of patient and provider interest, we were able to complete enrollment of some of these trials within weeks. In addition to evaluating multiple hepatitis C drug combinations in diverse genotypes and patient populations, we are investigating ways to shorten therapy from one year to a matter of weeks.

Edward Gane, MD, Professor of Medicine at the University of Auckland, New Zealand, is a leading expert on treating chronic hepatitis C. As the principal investigator of the ELECTRON study of Gilead's investigational agent sofosbuvir, Dr. Gane is excited by the potential of all-oral regimens that could make treatment more effective and tolerable for patients.



# EXCELLENCE: SEEKING TO IMPROVE TREATMENT FOR CANCER



## Insights from Molecular Biology

Scientific understanding of the biological mechanisms underlying cancer is rapidly increasing—and this understanding is leading to potential breakthroughs in therapy. One area of focus at Gilead involves investigational new agents that specifically target intracellular signaling pathways responsible for tumor growth. Another approach involves targeting the extracellular matrix, which supports the system that helps enable solid tumor growth. Importantly, certain targeted agents may have fewer side effects than conventional treatments, such as chemotherapy.



Image colors have been modified.

## Improving Patient Outcomes

At Gilead, we are developing new treatment options that may target a range of cancers. We are also exploring the utility of medications used as combination therapy for diseases that are among the most difficult to treat. Our work is informed by a robust understanding of biology and focuses on interrupting key pathways involved in the formation and replication of cancerous cells.

Tessa St. Rose is a Clinical Research Coordinator at Stanford University, where she helps people with serious blood cancers enroll in research studies of investigational therapies. Driven by the potential to help patients and their families at a critical time, she sees her role as an essential bridge between her patients and the often- complex clinical trial process. Tessa works closely with her patients to answer questions, explain research protocols and schedule study visits—all important steps in the search to find new treatments for today and in the future.



# TO OUR
STOCKHOLDERS,
EMPLOYEES
& FRIENDS:



Left to right: Gregg H. Alton, Executive Vice President, Corporate and Medical Affairs; Kevin Young CBE, Executive Vice President, Commercial Operations; Robin L. Washington, Senior Vice President and Chief Financial Officer; John C. Martin, PhD, Chairman and Chief Executive Officer; Norbert W. Bischofberger, PhD, Executive Vice President, Research and Development and Chief Scientific Officer; Katie L. Watson, Senior Vice President, Human Resources; John F. Milligan, PhD, President and Chief Operating Officer

2012 was an exceptional year for Gilead Sciences. The company achieved revenues of $9.7 billion, including product sales of $9.4 billion, and delivered its medicines to a record number of people with serious diseases around the world. Importantly, significant progress was made advancing R&D programs across our therapeutic areas.

June 22, 2012 marked the 25th anniversary of Gilead's founding. The company has grown rapidly from a biotech start-up to a multinational biopharmaceutical company with over 5,000 employees spanning 26 countries on four continents. The organization is inspired by the opportunity to address the needs of patients and those involved in improving patient care: patients like Katie (cover) and Jamie (page 3), physicians like Edward Gane (page 5), and healthcare providers such as Tessa St. Rose (page 7).

## HIV/AIDS

Scientific advancements—in drug design, formulation and delivery—and public health advancements—in disease awareness, screening and linkage to care—collectively have stemmed the global HIV/AIDS epidemic. This is a remarkable statement to make—30 years into the AIDS pandemic, and after 30 million lives lost. At the International AIDS Conference in Washington, DC in July 2012, a new optimism emerged, fueled by improvements in HIV prevention, diagnosis and care around the world.

Gilead remains at the forefront of advancing HIV treatment through the development of new single tablet regimens. In August 2012, the U.S. Food and Drug Administration (FDA) approved Stribild \( ^{®} \)  the company's third single tablet regimen. Stribild combines four medi-cations into a complete HIV treatment regimen in a once-daily pill. This approach helps allow patients to adhere to a fully suppressive course of therapy more easily and consis-tently, which is critical for the successful management of the disease. Our commercial organization introduced the product imme-diately following its approval. In 2012, Stribild, along with Artipla \( ^{®} \)  and Comparela \( ^{®} $ , achieved close to $4 billion in product sales.

The long-term goal is to ensure that all HIV patients, working with their prescribers, have the option to choose a single tablet regimen that may be right for them. Important progress was made in the development program for tenofovir alafenamide (TAF; GS-7340), a nucleotide reverse transcriptase inhibitor. TAF may be able to exhibit greater antiviral efficacy than Viread \( ^{®} \)  at a dose that is 10 times lower, which could help to improve tolerability of therapy. Interim findings from an ongoing Phase 2 study showed that a TAF-containing single tablet regimen achieved a similar virologic response to Stribild. In early 2013, we initiated the first Phase 3 study evaluating TAF as part of a single tablet regimen.

In July 2012, the U.S. FDA approved Truvada \( ^{®} \)  for pre-exposure prophylaxis (PrEP)—marking the first time a product has been approved for reducing the risk of HIV infection in high-risk adults in combination with safer sex practices. This key advancement in the fight against HIV was the result of decades of work involving investigators, academic and medical institutions, funding agencies and more than 20,000 clinical trial participants around the world.

In addition to clinical interventions such as PrEP, Gilead continued to support education and outreach to increase access to HIV testing and care worldwide. Our partners have conducted more than 300,000 HIV tests, which represents an important contribution to public health by helping to diagnose infected individuals and connect them to care. In November 2012, the U.S. Preventive Services Task Force recommended routine HIV testing



for adolescents and adults ages 15–65, and will require that private insurers cover the cost of screening.

## Liver Diseases

With the Pharmacist acquisition completed in January 2012, a leadership position was established in the drug development for chronic hepatitis C virus (HCV) infection. Over the last year we have advanced the nucleotide NSSB inhibitor sofosbuvir (GS-7977) and a once-daily fixed-dose combination tablet containing sofosbuvir and the NS5A inhibitor ledipasvir (GS-5885) into Phase 3 testing. Our goal is to transform the paradigm of HCV care by developing an all-or-treatment regimen that has higher cure rates, better tolerability and greater convenience for patients than currently available options.

In November 2012, the first data showing the efficacy of sofosbuvir and ledipasvir plus ribavirin were presented at The Liver Meeting, the annual conference of the American Association for the Study of Liver Diseases. Interim results from a Phase 2 study suggested that a 12-week course of these medicines in patients infected with genotype 1 HCV—the most common strain in the United States and the most difficult to treat—resulted in 100 percent of participants (n=25) remaining HCV RNA undetectable four weeks after completing therapy (SVR4). Phase 3 trials exploring sofosbuvir in various combinations in genotype 1-6 patient populations are ongoing. Initial regulatory filings are expected in the first half of 2013, and the appropriate commercial infrastructure is now being assembled to support the potential launch of sofosbuvir.

Also at The Liver Meeting, six-year clinical trial data for Viread for the treatment of chronic hepatitis B virus (HBV) infection was presented, which showed sustained virological and biochemical responses among patients, with no evidence of viral resistance. These results reinforce Viread's position as the most-prescribed medicine for chronic HBV in the United States and most European countries.

## Cardiovascular, Respiratory & Oncology/Inflammation

Across therapeutic areas, we look for ways to appropriately expand the use of available medicines and to advance investigational therapies to address the unmet needs of patients. In cardiovascular disease, Ranexa \( ^{®} \)  on oral late sodium current inhibitor that is currently indicated for chronic angina, is also being explored in Phase 3 studies for type 2 diabetes. In addition, a new generation of late sodium current inhibitors are being developed, such as GS-6615, which is currently in Phase 1 studies and has the potential to treat ischemic heart disease and arrhythmias. In the area of pulmonary arterial hypertension (PAH), a Phase 4 research program has been designed to advance the understanding of the disease pathology and further define the clinical profile (Letaris \( ^{®} \)  including the potential for the product to be used in combination with another oral PAH treatment as frontline therapy.

In the area of respiratory disease, Cayston \( ^{®} \)  in inhaled antibiotic approved to treat cystic fibrosis (CF) patients with Pseudomonas aeruginosa, is being evaluated in Phase 3 studies to assess its efficacy in treating bacterial infections associated with non-CF bronchiectasis. Results from these trials are expected in 2013.

In addition, we are evaluating GS-5806 in Phase 2 clinical trials. This compound has been shown in preclinical studies to block respiratory syncytial virus (RSV). RSV is a pathogen that infects the human respiratory tract, leading to bronchiolitis and pneumonia. It is estimated that 125,000 newborns are hospitalized with RSV every year in the United States.
In the area of oncology, the company is advancing novel therapies that target key molecular signaling pathways and the extracellular matrix involved in the growth and survival of certain cancers for which existing treatment options are limited. Idelalisib (GS-1101), a PI3K delta inhibitor, is currently being evaluated in Phase 3 studies for indolent non-Hodgkin's lymphoma and chronic lymphocytic leukemia. Simutzumab is also progressing through Phase 2 studies to assess its safety and efficacy in treating pancreatic and colorectal cancer, myelofibrosis and certain fibrotic diseases. With the recent completion of the YM BioSciences acquisition, the selective JAK inhibitor mometolinitn (GS-0387/CTY-387) was added to a growing oncology and inflammation pipeline. A Phase 3 study of mometolinitn in myelofibrosis is planned for the second half of 2013.
Increasing Access

Because many patients around the globe do not have the resources to obtain the medicines they need, we work to expand treatment access wherever possible. The company's comprehensive patient assistance programs provide medicines in the United States at no cost for low-income, uninsured patients, and co-pay assistance coupon programs help those unable to afford the co-payments associated with commercial health insurance programs.

Gilead is also expanding access to its medications in resource-limited parts of the world—including developing countries where the HIV/AIDS epidemic is affecting millions of people. As of December 2012, approximately 3.5 million patients in the developing world were receiving one of Gilead's HIV medicines, more than doubling the number of patients reached since 2010.
Closing

In summary, the organization has a strong business foundation, with over $9 billion in revenues in 2012. And, we continue to make significant progress in advancing new therapies to solidify our future growth.

I would like to thank our employees for their commitment to excellence and hard work. I also would like to acknowledge the invaluable input of our Board of Directors.

Thank you for your continued support. We look forward to the year ahead—and to the progress we believe we can make for many more patients around the world.

John C. Martin, PhD
Chairman and Chief Executive Officer

Forward-Looking Statement

This Annual Report includes forward-looking statements regarding our clinical studies and product candidates, including the anticipated timing and achievement of certain development milestones, regulatory filings and launches. Such statements are predictions and involve risks and uncertainties such that actual results may differ materially. Please refer to Gilead's Annual Report on Form 10-K for the year ended December 31, 2012 attached to this report for the risks and uncertainties affecting Gilead's business. Gilead disclaims any obligation to update any forward-looking statements in this report.
















Gilead is working to develop the next generation of HIV single tablet regimens that are effective, tolerable and convenient and that may provide certain advantages over existing treatment options. This is particularly important as more individuals with HIV are diagnosed and brought into care, because life-long treatment is required to control the virus.

We are conducting clinical trials of tenofovir alafen-amide (TAF; GS-7340); TAF may be able to exhibit greater antiviral efficacy than Viread \( ^{®} \)  at a dose that is 10 times lower, which may improve the tolerability of HIV therapy. Phase 3 studies will examine a once-daily single tablet regimen of TAF, Emtriva \( ^{®} \)  the integrase inhibitor elvitegravir and the boosting agent cobicistat, compared to Stribild \( ^{®} \)  among patients new to HIV therapy.

While HIV medicines reduce the level of virus in the blood to undetectable levels, the ultimate goal is to develop a cure. Gilead scientists are engaged in early-stage research to identify novel therapeutic agents that may help eradicate HIV infection.

* The earnings per share calculations for all periods presented reflect the two-for-one stock split effective on January 25, 2013.

• Non-GAAP diluted earnings per share for 2010 exclude the impact of after-tax acquisition-related expenses of $0.08, restructuring expenses of $0.02 and stock-based compensation expenses of $0.08.

• Non-GAAP diluted earnings per share for 2011 exclude after-tax acquisition-related expenses of $0.05 and stock-based compensation expenses of $0.09.

• Non-GAAP diluted earnings per share for 2012 exclude after-tax acquisition-related expenses of $0.08, restructuring expenses of $0.01 and stock-based compensation expenses of $0.22.



Chronic hepatitis B and C are caused by persistent viral infections, and can frequently lead to liver cirrhosis, liver failure and cancer.

Chronic hepatitis B can be treated using Viread \( ^{®} \)  which in one ongoing clinical study showed a regression of cirrhosis after five years of therapy in approximately 75 percent of patients for whom baseline liver biopsy data were available. For most patients with chronic hepatitis B, life-long antiviral therapy is required. Because of this, we continue to research combination approaches to increase cure rates in chronic hepatitis B patients, including oral medicines and therapeutic vaccines.

Gilead is also advancing a broad and diverse pipeline of investigational treatments for chronic hepatitis C, with the ultimate goal of developing an all-oral regimen that works across all strains of the virus and which results in high cure rates with a shorter treatment duration than today's therapies. We have completed four Phase 3 studies of sofosbuvir (GS-7977) as a single agent administered with standard of care therapies. Positive results from these trials were announced in late 2012 and early 2013, and will support initial regulatory applications for the compound in 2013. Additionally, we have developed a once-daily fixed-dose combination of sofosbuvir with ledipasvir (GS-5885), which is now in Phase 3 studies.

People living with chronic hepatitis C often have other viral diseases, including HIV, and many patients await liver transplantation. Because of this, we are also evaluating hepatitis C treatments in diverse and difficult-to-treat patient groups.

Diana Brainard, MD, Senior Director, Clinical Research, Liver Diseases, Gilead Sciences
Phil Pang, MD, Director, Clinical Research, Liver Diseases, Gilead Sciences



CHRONIC HEPATITIS C
PHASE 3
SOFOSBUVIR (NUCLEOTIDE NS5B INHIBITOR) AND LEDIPASVIR
SINGLE TABLET REGIMEN OF SOFOSBUVIR AND
(NUCLEOTIDE NS5B INHIBITOR/NS5A INHIBITOR)

PHASE 2
GS-9451 (NS3 PROTAGE INHIBITOR)
GS-9669 (NON-NUCLEOSIDE NS5B INHIBITOR)
GS-5816 (PAN-GENTOPIC NS5A INHIBITOR)

PHASE 1
GS-9620 (TLR-7 AGONIST)

CHRONIC HEPATITIS B
PHASE 1
GS-9620 (TLR-7 AGONIST)
TENOFOVIR ALFALENAMIDE
(NUCLEOTIDE REVERSE TRANSCRIPTASE INHIBITOR)

LIVER FIBROSIS DUE TO NONALCOHOLIC STEVITIBOR) OR PRIMARY SCLEROSING CHOLANGITIS

PHASE 2
SIMTUZUMAB* (MONOCLONAL ANTIBODY)
* Formerly GS-6624



PHASE 3
RANOLAZINE (LATE SODIUM CURRENT INHIBITOR)
POTENTIAL INDICATION: INCOMPLICATION
REVASCULARIZATION POST-PCI
RANOLAZINE (LATE SODIUM CURRENT INHIBITOR)
POTENTIAL INDICATION: TYPE 2 DIABETES

PHASE 2
RANOLAZINE/DRONEDARONE FIXED-DOSE
COMBINATION
POTENTIAL INDICATION: PAROXYSMAL ATRIAL
FIBRILLATION

PHASE 1
GS-6615
POTENTIAL INDICATIONS: ISCHEMIC HEART DISEASE
AND ARRHYTHMIAS

Cardiovascular disease and diabetes each represent a considerable public health burden worldwide. There is a significant unmet medical need for new therapeutic options for patients living with these conditions.

A number of clinical studies are ongoing to explore uses for Ranexa \( ^{®} \)  currently indicated for the treatment of chronic angina, that may potentially benefit specific populations of patients. This includes a study evaluating Ranexa in patients with both chronic angina and type 2 diabetes. Additional clinical trials are evaluating Ranexa in patients unable to control type 2 diabetes with currently available medications and in patients who have undergone stenting procedures.

We are working to identify potential new therapies for cardiovascular disease by exploring the mechanism of action underlying Ranexa—inhibition of the late sodium current. This research has led us to a Phase 2 clinical study evaluating Ranexa in combination with dronedarone for paroxysmal atrial fibrillation and to identify the novel molecule GS-6615 that may have potential to treat various cardiovascular diseases, such as ischemic heart disease and arrhythmias.

Even with the advancements of pulmonary arterial hypertension treatments such as Letaris \( ^{®} \)  there is a need to further optimize the use of existing agents. Because of this, Gilead continues to conduct Phase 4 studies to answer questions about optimal patient care and further define the clinical benefit of Letaris in broader patient populations.



Gilead’s first product in the category of respiratory disease, Tamiflu \( ^{®} \)  remains the leading antiviral for treatment and prevention of seasonal influenza.

Our inhaled antibiotic, Cayston \( ^{®} \)  is indicated to treat respiratory Pseudomonas aeruginosa in people with cystic fibrosis (CF), an inherited disease that affects the lungs and digestive system. We are also investigating the potential for Cayston to treat bacterial infections in people with non-CF bronchiectasis.

Simtuzumab (GS-6624) is a monoclonal antibody being investigated for the potential treatment of idiopathic pulmonary fibrosis, a life-threatening scarring of the lungs that has no known cause. GS-5806 is being studied for respiratory syncytial virus (RSV), which infects the human respiratory tract and can lead to bronchiolitis and pneumonia. RSV is the most common microbial cause of lung and airway infections in infants and young children.



PHASE 3
AZTREONAM FOR INHALATION SOLUTION
POTENTIAL INDICATION: NON-CF BRONCHIECTASIS

PHASE 2
SIMTZUMA® (MONOCLONAL ANTIBODY)
POTENTIAL INDICATION: IDIOPATHIC PULMONARY
FIBROSIS

GS-5806
POTENTIAL INDICATION: RESPIRATORY SYNCYTIAL
VIRUS



PHASE 3
IDEALISIB (P3K DELTA INHIBITOR)
POTENTIAL INDICATION: CHRONIC LYMPHOCYTIC LEUKEMIA
IDEALISIB (P3K DELTA INHIBITOR)
POTENTIAL INDICATION: INDOLENT NON-HODGKIN'S LYMPHOMA

PHASE 2
MOMELOTINIB (UAK INHIBITOR)
POTENTIAL INDICATION: MYELOFIBROSIS
SIMTZUMA® (MONOCLONAL ANTIBODY)
POTENTIAL INDICATION: MYELOFIBROSIS
SIMTZUMA® MONOCLONAL ANTIBODY)
POTENTIAL INDICATION: PANCREATIC CANCER
SIMTZUMA® (MONOCLONAL ANTIBODY)
POTENTIAL INDICATION: COLORECTAL CANCER
GS-9820 (P13X DELTA INHIBITOR)
POTENTIAL INDICATION: LYMPHODI MALIGNANCIES

PHASE 1
GS-9973* (SYN INHIBITOR)
POTENTIAL INDICATION: B-CELL MALIGNANCIES
* Being developed as a single agent and in combination with idealisib.
Oncology and inflammation are newer focus areas for Gilead. We are making rapid progress in identifying targeted investigational cancer therapies and evaluating them in clinical studies.

Our lead oncology candidates include idealisib (GS-1101) and mometinib (GS-0387/CYT-0387). Idealisib is a small molecule drug designed to inhibit the PI3K delta signaling pathway that is thought to drive certain cancer cell development. The compound is being studied in clinical trials for chronic lymphocytic leukemia and indolent non-Hodgkin's lymphoma. Mometinib is an investigational JAK inhibitor that has shown promise for the treatment of myelofibrosis, a blood disorder. This molecule was added to Gilead's development pipeline through the acquisition of YM BioSciences.

Simtuzumab (GS-6624) is the first monoclonal antibody developed to target LOXL2, an enzyme thought to be involved in solid tumor growth. It is being studied for pancreatic and colorectal cancers and myelofibrosis. In addition, GS-9973, our SYK inhibitor, is in clinical studies for B-cell malignancies.

Through partnerships, we are exploring new therapeutic targets in oncology. Our multi-year collaboration with Yale School of Medicine is searching for the genetic basis and underlying molecular mechanisms of many forms of cancer.

Derek Marshall, Research Scientist, Biology, Gilead Sciences
Vivian Barry, Associate Scientist, Biology, Gilead Sciences
Rhynnnon Spangler, Senior Research Associate, Biology, Gilead Sciences



Advancing therapies for life-threatening diseases requires innovation—not just in the laboratory but also in how medicines are delivered to patients. We make it a priority to ensure that people who need our therapies have access, regardless of their ability to pay or where they live in the world.

Ensuring Access in Developing World Countries
Many of the diseases our medicines treat place the greatest burden on developing world countries with the fewest resources. To address this challenge, Gilead works with more than 70 manufacturers, regional and local distributors and generic licensees to lower prices and enable generic production of certain Gilead medicines for HIV/AIDS and chronic hepatitis B. In 2012, we began transferring the technology for Stribild \( ^{®} \)  our newest HIV single tablet regimen, so that these partners can begin the process of producing generic versions for patients in low- and middle-income countries. We also coordinate and support educational activities for medical and clinical workers to ensure proper use of our medicines.

2012 also marked the first year of a five-year expanded partnership with the World Health Organization to control visceral leishmaniasis (V.L), the second-deadliest parasitic disease after malaria. Gilead will provide enough Ambisome \( ^{®} \)  to treat 50,000 patients with V.L.

## Ensuring Access in the United States

Recognizing the financial difficulties many Americans face in today's economy, Gilead has established one of the most comprehensive packages of patient assistance solutions. This includes providing our medicines to eligible patients at no charge and offering a co-pay coupon program for patients with private insurance, regardless of income. We also have a long history of working with state AIDS Drug Assistance Programs (ADAPs) to increase access to HIV treatment. A voluntary price freeze and additional discounts for ADAPs for our HIV medicines run through 2013.



## ACCESS HIGHLIGHTS

• Three and a half million HIV patients in 130 low- and middle-income countries are receiving Gilead therapies—representing approximately one-third of people being treated for HIV in these countries.

• 15 Indian manufacturers and one South African manufacturer have been licensed to produce generic versions of our HIV and chronic hepatitis B medicines for developing countries.

• Half of all people in the United States taking Gilead HIV medicines receive them through federal and state programs at substantially discounted prices.

## HIV/AIDS



## ATRIPLA \( ^{®} \) 

EFAVIRENZ 600 MG/EMTRICITABINE
200 MG/TENOFOVIR DISOPROXIL
FUMARATE 300 MG

HIV AIDS
BRISTOL-MYERS SQUIBB COMPANY
(U.S., WESTERN EUROPE, CANADA)
MERCK & CO., INC. (REST OF WORLD)



## COMPLERA \( ^{®} \) 

EMTRICITABINE/RIPLIVIRINE/TENOFOVIR
DISOPROXIL FUMARATE

HIV/AIDS

JANSSEN R&D IRELAND



## EMTRIVA \( ^{®} \) 

EMTRICITABINE

HIV/AIDS

JAPAN TOBACCO INC. (JAPAN)



## STRIBIOLD \( ^{®} \) 

ELVITEGRAVIR 150MG/COBICISTAT 150MG/
EMTRICITABINE 200MG/TENOFOVIR
DISOPROXIL FUMARATE 300MG

HIV/AIDS

JAPAN TOBACCO INC. (JAPAN)



## TRUVADA \( ^{®} \) 

EMTRICITABINE/TENOFOVIR
DISOPROXIL FUMARATE
HIV/AIDS

JAPAN TOBACCO INC. (JAPAN)



## VIREAD \( ^{®} \) 

TENOFOVIR DISOPROXIL FUMARATE

HIV/AIDS

JAPAN TOBACCO INC. (JAPAN)

## LIVER DISEASE



## HEPSERA \( ^{®} \) 

ADEFOVIR DIPIVOXIL

CHRONIC HEPATITIS B
GLAXOSMITHKLINE INC.
(CHINA, JAPAN, SAUDI ARABIA)



## VIREAD \( ^{®} \) 

TENOFOVIR DISOPROXIL FUMARATE

CHRONIC HEPATITIS B
JAPAN TOBACCO INC. (JAPAN)



## CARDIOVASCULAR



## LETAIRIS \( ^{®} \) 

AMBISOME \( ^{®} \) 

PULMONARY ARTERIAL HYPERTENSION
(WHO GROUP 1)

GLAXOSMITHKLINE INC.
MARKETED AS VOLIBRIS \( ^{®} \)  OUTSIDE OF THE U.S.



## LEXISCAN \( ^{®} \) 

REGADENOSON INJECTION

CORONARY VASODILATION

ASTELLAS PHARMA INC. (U.S., CANADA)
RAPIDSCAN (EUROPE AND SELECT OTHER

MARKETS)



## RANEXA \( ^{®} \) 

RANOLAZINE

CHRONIC ANGINA

MENARINI GROUP (EUROPE)

## RESPIRATORY



## CAYSTON \( ^{®} \) 

AZTREONAM FOR INHALATION SOLUTION
CYSTIC FIBROSIS, PAEURIGINOSA



## TAMIFLU \( ^{®} \) 

OSELTAMIVIR PHOSPHATE

INFLUENZA A & B

F. HOFEMANN-LA ROCHE LTD
(WORLDWIDE)

## OTHER



## AMBISOME \( ^{®} \) 

AMPHOTERICIN B LIPOSOME FOR

INJECTION

SEVERE FUNGAL INFECTIONS

ASTELLAS PHARMA INC. (U.S., CANADA)
DAINIPPON SUMITOMO PHARMA CO., LTD.
(JAPAN)



## MACUGEN \( ^{®} \) 

PEGAPTAINBI SODIUM INJECTION

NEOVASCULAR (WET) AGE-RELATED MACULAR DEGENERATION

EYETECH, INC. (U.S.)
PFIZER INC. (OUTSIDE U.S.)



## VISTIDE \( ^{®} \) 

CIDOFOVIR INJECTION
CMV RETINITIS IN PATIENTS WITH AIDS



## CORPORATE
INFORMATION

BOARD OF DIRECTORS
John C. Martin, PhD
Chairman and Chief Executive Officer,
Gilead Sciences

James M. Denny
Lead Independent Director,
Gilead Sciences Board of Directors

John F. Cogan, PhD
Senior Fellow, Hoover Institution,
Stanford University

Etienne F. Davignon
Minister of State,
Chairman, Genfina

Carla A. Hills
Chair and Chief Executive Officer,
Hills & Company International
Consultants

Kevin E. Lofton
President and Chief Executive Officer,
Catholic Health Initiatives

John W. Madigan
Retired Chairman and
Chief Executive Officer,
Tribune Company

Gordon E. Moore, PhD
Retired Chairman and
Chief Executive Officer,
Intel Corporation

Nicholas G. Moore
Retired Global Chairman,
PricewaterhouseCoopers

Richard J. Whitley, MD
Distinguished Professor,
Loeb Scholar Chair in Pediatrics,
Professor of Pediatrics, Microbiology,
Medicine, and Neurosurgery,
University of Alabama at Birmingham

Gayle Edlund Wilson
Former Chair, Ralph M. Parsons
Foundation

Per Wold-Olsen
Retired President, Human Health
Intercontinental Division,
Merck & Co., Inc.

DIRECTOR EMPERILS, GILEAD SCIENCES
BOARD OF DIRECTORS
George P. Schultz, PhD
Distinguished Fellow,
Hoover Institution,
Stanford University
SENIOR LEADERSHIP TEAM
John C. Martin, PhD
Chairman and Chief Executive Officer

John F. Milligan, PhD
President and Chief Operating Officer

Norbert W. Bischofberger, PhD
Executive Vice President,
Research and Development and
Chief Scientific Officer

Gregg H. Alton
Executive Vice President,
Corporate and Medical Affairs

Kevin Young CBE
Executive Vice President,
Commercial Operations

Robin L. Washington
Senior Vice President and
Chief Financial Officer

Katie L. Watson
Senior Vice President,
Human Resources

SCIENTIFIC ADVISORY BOARD
Joel R. Huff, PhD (Chirperson)
Retired Vice President of
Medical Chemistry,
Merck Research Laboratories

Paul Berg, PhD
Cahill Professor of
Biochemistry, Emeritus,
Stanford University School of Medicine

Francis V. Chisari, MD
Professor of Virology and Immunology,
The Scripps Research Institute

Peter B. Dervan, PhD
Bren Professor of Chemistry,
California Institute of Technology

Paul E. Klotman, MD
President and Chief Executive Officer,
John E. and Clara B. Whitmore
Professor, Baylor College of Medicine

John W. Mellors, MD
Professor of Medicine,
Chief, Division of Infectious Diseases,
University of Pittsburgh School
of Medicine

Eugene R. Schiff, MD
Leonard Miller Professor of Medicine,
Director for Schiff Liver Institute,
Director for Center for Liver Diseases,
University of Miami School
of Medicine
Robert T. Schooley, MD
Professor of Medicine and Head,
Division of Infectious Diseases,
Vice Chair of Department of Medicine,
University of California, San Diego

Eric J. Topol, MD
Director, Scripps Translational
Science Institute
Chief Academic Officer, Scripps Health
Professor of Genomics,
The Scripps Research Institute

Bernard M. Wagner, MD
Emeritus Research Professor
of Pathology, New York University
Medical Center

CORPORATE SECRETARY
Gregg H. Alton
Executive Vice President, Corporate
and Medical Affairs

INDEPENDENT REGISTERED PUBLIC ACCOUNTANTS
Ernst & Young LLP
Palo Alto, California

CORPORATE HEADQUARTERS
Gilead Sciences, Inc.
333 Lakeside Drive
Foster City, CA 94404 USA
(800) 445-3235 or (650) 574-3000
www.gilead.com

STOCKHOLDER INQUIRIES
Inquiries from our stockholders and
potential investors regarding our company
are always welcome and will receive a
prompt response. Please direct your
requests for information to:

Investor Relations
Gilead Sciences, Inc.
333 Lakeside Drive
Foster City, CA 94404 USA
(800) 445-3235 or (650) 574-3000

Information regarding Gilead also is available at www.gilead.com.

STOCK LISTING
Gilead common stock is traded on the
Nasdaq Global Select Stock Market.
under the symbol GILD.

ANNUAL MEETING
The annual meeting of stockholders will be held at 10:00 a.m. on Wednesday, May 8, 2013, at the Westin San Francisco Airport Hotel.

TRANSFER AGENT AND REGISTRAR
Communications concerning stock
transfer requirements, lost certificates
and changes of address should be
directed to the Transfer Agent:

Computershare
480 Washington Boulevard
Jersey City, NJ 07310-1900
USA
(800) 710-0940
www.computershare.com

EQUAL OPPORTUNITY EMPLOYER
Gilead Sciences is proud to be an equal opportunity employer and extends employment to men and women from culturally diverse backgrounds. Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.





Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide. Headquartered in Foster City, California, Gilead has operations in North America, Europe and Asia Pacific.

AmBisome, Cayston, Compare, Emtriva, Eviplera, Gilead, Gilead Sciences, the Gilead logo design, Hepsera, Letaris, Ranexa, Stribild, Truvada, Viread, Vistide and Volbris are registered trademarks of Gilead Sciences, Inc, or one of its related companies. Artipla is a registered trademark of Bristol-Myers Squibb & Gilead Sciences, LLC. Lexiscan is a registered trademark of Astellas U.S. LLC. Tamiflu is a registered trademark of Hoffmann-La Roche Inc. Macugen is a registered trademark of Eyetech, Inc.

Full U.S. prescribing information for Gilead products is available at www.gilead.com.



GILEAD SCIENCES, INC.
333 LAKESIDE DRIVE
FOSTER CITY, CALIFORNIA
94404

650 574 3000 T
800 445 3235
650 578 9264 F
WWW.GILEAD.COM