A significant proportion of patients with seropositive RA receiving NNC@-@ , compared to those receiving placebo , achieved treatment responses according to the American College of Rheumatology @ % ( ACR@ ) ( @ % versus @ % ) , ACR@ ( @ % versus @ % ) , and ACR@ ( @ % versus @ % ) levels of improvement , and showed greater improvements in the Health Assessment Questionnaire disability index ( P = @ ) .