In total , @,@ men ( mean age = @ y ) and women ( mean age = @ y ) were randomized in a @ factorial design to : @ ) @ mg @-methyl-tetrahydrofolate , @ mg vitamin B@ , @ mg vitamin B@ ; @ ) @ mg eicosapentaenoic and docosahexaenoic acids in a @ ratio ; @ ) B vitamins and n-@ fatty acids combined ; or @ ) placebo .