Between Nov @ , @ , and Nov @ , @ , @ patients were randomly assigned to receive benzathine benzylpenicillin ( n = @ -LSB- @ analysed -RSB- ) , twice-daily co-trimoxazole for @ days ( n = @ -LSB- @ analysed -RSB- ) , or once-daily co-trimoxazole for @ days ( n = @ -LSB- @ analysed -RSB- ) .