The Euro-EWING@-R@ trial asked whether cyclophosphamide may replace ifosfamide in combination with vincristine and dactinomycin ( vincristine , dactinomycin , and cyclophosphamide -LSB- VAC -RSB- v vincristine , dactinomycin , and ifosfamide -LSB- VAI -RSB- ) after an intensive induction chemotherapy containing vincristine , ifosfamide , doxorubicin , and etoposide ( VIDE ) in standard-risk localized disease ( NCT@ ) .