In this open-label , multicentre , phase @ , randomised trial , patients with postoperative pathological stage II ( ypT@-@N@ ) or III ( ypTanyN@-@ ) rectal cancer after preoperative fluoropyrimidine-based chemoradiotherapy and total mesorectal excision were recruited and randomly assigned ( @:@ ) via a web-based software platform to receive adjuvant chemotherapy with either four cycles of fluorouracil and leucovorin ( fluorouracil @ mg/m ( @ ) and leucovorin @ mg/m ( @ ) on days @-@ , every @ weeks ) or eight cycles of FOLFOX ( oxaliplatin @ mg/m ( @ ) , leucovorin @ mg/m ( @ ) , and fluorouracil bolus @ mg/m ( @ ) on day @ , and fluorouracil infusion @ mg/m ( @ ) for @ h , every @ weeks ) .