The most common grade @ or worse adverse events were neutropenia ( @ -LSB- @ % -RSB- of @ patients in the fluorouracil plus leucovorin group vs @ -LSB- @ % -RSB- of @ patients in the FOLFOX group ) , leucopenia ( eight -LSB- @ % -RSB- vs @ -LSB- @ % -RSB- ) , febrile neutropenia ( four -LSB- @ % -RSB- vs one -LSB- < @ % -RSB- ) , diarrhoea ( four -LSB- @ % -RSB- vs two -LSB- @ % -RSB- ) , and nausea ( one -LSB- < @ % -RSB- vs two -LSB- @ % -RSB- ) .