Change from baseline in CGI-S scores was statistically significantly greater in both cariprazine groups compared with placebo ( LSMD -LSB- @ % CI -RSB- : @-@ mg/d , -@ -LSB- -@ to -@ -RSB- ; @-@ mg/d , -@ -LSB- -@ to -@ -RSB- ; P < @ -LSB- both -RSB- ) .