The aim of this prospective randomized controlled cross sectional study was to evaluate the effect of a six month tibolone treatment in healthy postmenopausal women on biochemical CVD markers by calculating the changes of the blood serum levels of total cholesterol ( TC ) , low-density lipoprotein ( LDL ) , high-density lipoprotein ( HDL ) , triglycerides ( Tg ) , high-sensitivity C-reactive protein ( hsCRP ) , homocysteine ( Hcy ) , and endothelin-@ ( ET-@ ) at the beginning of the treatment and after six months .