The maximum concentration that the drug achieved after dosing ( Cmax ) , time to Cmax ( Tmax ) , terminal half-life ( t / ) , area under the curve from time zero to time of last quantifiable concentration ( AUC ( @ , t ) ) , area under the curve from time zero to infinity ( AUC ( @ , ) ) , apparent total plasma clearance ( CL/F ) , and apparent total volume of distribution ( V/F ) were determined using non-compartmental models .