Subjects were assessed using the patient assessment of constipation ( PAC ) - symptoms ( PAC-SYM ) and the PAC-quality of life ( PAC-QOL ) scales measured at baseline and Day @ ; Subjects were assessed daily for secondary measures included the Bristol stool scale bowel consistency , specific bowel symptom score ( Nausea , cramping , straining , completeness , abdominal pain , time per lavatory attempt , assistance needed ) , adverse events and rescue medications required .