Data from an RCT ( Trial of Etanercept and Methotrexate with Radiographic Patient Outcomes -LSB- TEMPO -RSB- ; n = @ ) and an observational registry ( Rheumatoid Arthritis DMARD Intervention and Utilization Study -LSB- RADIUS II -RSB- ; n = @ ) were used to evaluate disease activity ( Clinical Disease Activity Index -LSB- CDAI -RSB- score ) over time in patients initiating etanercept ( monotherapy or with methotrexate ) .