Study @ : @ lean subjects received placebo or physiologic replacement-dose recombinant human leptin ( metreleptin ) following short term complete caloric deprivation to induce severe hypoleptinemia ; Study @ : @ women with relative leptin deficiency due to strenuous exercise or low weight received @ months of metreleptin ; Study @ : @ women with relative leptin deficiency were randomized to receive metreleptin or placebo over @ months .