Per-protocol treatment effectiveness was @ % ( @ % CI @ % to @ % ) for PPI-CA and @ % ( @ % CI @ % to @ % ) for ST. Based on intention to treat , effectiveness was @ % ( @ % CI @ % to @ % ) for PPI-CA and @ % ( @ % CI @ % to @ % ) for ST. Of @ participants ( @ PPI-CA , @ ST ) with @ % adherence , effectiveness was @ % ( @ % CI @ % to @ % ) for PPI-CA and @ % ( @ % CI @ % to @ % ) for ST.