Grade @-@ adverse events related to nivolumab included increased lipase ( three -LSB- @ % -RSB- of @ patients ) , increased alanine aminotransferase , anaemia , and fatigue ( two -LSB- @ % -RSB- each ) ; for ICC , these included neutropenia ( @ -LSB- @ % -RSB- of @ ) , thrombocytopenia ( six -LSB- @ % -RSB- ) , and anaemia ( five -LSB- @ % -RSB- ) .