While this difference was not significant ( odds ratio = @ , @ % CI @-@ @ , Wald @ -LSB- df -RSB- = @ -LSB- @ -RSB- , p = @ ) , naltrexone treatment led to a significantly greater decrease in QUIP-RS ICD score over time compared with placebo ( regression coefficient for interaction term in linear mixed-effects model = -@ , F -LSB- df -RSB- = @ -LSB- @ , @ -RSB- , p = @ ) .