In patients assigned to STICH Hypothesis @ ( n = @ ) , no genetic variant met the prespecified Bonferroni-adjusted threshold for statistical significance ( p < @ ) ; however , several variants met nominal prognostic significance : variants in the @-adrenergic receptor gene ( @-AR Gln@Glu ) and in the A@-adenosine receptor gene ( A@-@ T/G ) were associated with an increased risk of a subject dying or being hospitalized for a cardiac problem ( p = @ and @ , respectively ) .