Nevertheless , there was a trend toward worse DFS among patients with the variant allele of MTHFR C@T compared with wild-type , particularly in treatment arm @ , in which patients with the MTHFR C@T TT genotype had worse overall survival ( hazards ratio , @ ; @ % confidence interval , @-@ @ -LSB- P = @ -RSB- ) and DFS ( hazards ratio , @ ; @ % confidence interval , @-@ @ -LSB- P = @ -RSB- ) compared with those with homozygous wild-type .