They were randomly assigned ( @:@ ) by the minimisation method to either doxorubicin ( @ mg/m ( @ ) by intravenous bolus on day @ or @ h continuous intravenous infusion ) or intensified doxorubicin ( @ mg/m ( @ ) ; @ mg/m ( @ ) per day , days @-@ ) plus ifosfamide ( @ g/m ( @ ) over @ days with mesna and pegfilgrastim ) as first-line treatment .