Dose reduction decreased mean exposure by @ % ( from @ ng/mL -LSB- SD @ -RSB- to @ ng/mL -LSB- @ -RSB- ) and @ % ( from @ ng/mL -LSB- @ -RSB- to @ ng/mL -LSB- @ -RSB- ) and mean anti-FXa activity by @ % ( from @ IU/mL -LSB- @ -RSB- to @ IU/mL -LSB- @ -RSB- ) and @ % ( from @ IU/mL -LSB- @ -RSB- to @ IU/mL -LSB- @ -RSB- ) in the higher-dose and lower-dose regimens , respectively .