Placebo-subtracted least squares mean ( LSM ) ( SEM ) changes were @ ( @ ) and @ ( @ ) pmol min ( -@ ) m ( -@ ) ( mmol/l ) ( -@ ) with canagliflozin @ and @ mg , respectively ( p < @ , Study @ ) , and @ ( @ ) and @ ( @ ) pmol min ( -@ ) m ( -@ ) ( mmol/l ) ( -@ ) ( p < @ , Study @ ) .