The least squares mean difference ( LSMD ) for change from baseline to week @ in YMRS total score was statistically significant in favor of both cariprazine groups versus placebo ( LSMD -LSB- @ % CI -RSB- : @-@ mg/d , -@ -LSB- -@ to -@ -RSB- ; @-@ mg/d , -@ -LSB- -@ , -@ -RSB- ; P < @ -LSB- both -RSB- ) .