Weight loss-induced improvements in risk factors were similar among the three groups , except for a greater reduction in fasted glucose in the HT group ( difference in change -LSB- @ % CI -RSB- from placebo ; -@ -LSB- -@ , -@ -RSB- ) and greater reductions in LDL ( -@ -LSB- -@ , -@ -RSB- ) and increases in HDL ( @ -LSB- @ , @ -RSB- ) in both treatment groups .