Fluralaner was administered on three occasions at @-week intervals at doses of up to @ , @ , and @ mg fluralaner/kg body weight , equivalent to @ , @ , and @ times the highest recommended treatment dose of fluralaner ; sham dosed dogs served as controls.During the study , all dogs were clinically observed , and their health was carefully monitored including body weight development , food consumption and measurement of hematology , coagulation , clinical chemistry ( including measurement of levels of ACTH and C-reactive protein ) and urinalysis .