We randomly assigned patients with newly diagnosed , smear-positive , drug-sensitive tuberculosis to one of three regimens : a control regimen that included @ months of ethambutol , isoniazid , rifampicin , and pyrazinamide administered daily followed by @ months of daily isoniazid and rifampicin ; a @-month regimen in which the isoniazid in the control regimen was replaced by moxifloxacin administered daily for @ months followed by moxifloxacin and @ mg of rifapentine administered twice weekly for @ months ; or a @-month regimen in which isoniazid was replaced by daily moxifloxacin for @ months followed by one weekly dose of both moxifloxacin and @ mg of rifapentine for @ months .